Motif 1180 (n=269)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AVT1 | UBA6 | S16 | ochoa | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:35970836, PubMed:35986001). Specific for ubiquitin, does not activate ubiquitin-like peptides. Also activates UBD/FAT10 conjugation via adenylation of its C-terminal glycine (PubMed:17889673, PubMed:35970836, PubMed:35986001). Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269|PubMed:15202508, ECO:0000269|PubMed:17597759, ECO:0000269|PubMed:17889673, ECO:0000269|PubMed:35970836, ECO:0000269|PubMed:35986001}. |
| A1L170 | C1orf226 | S16 | ochoa | Uncharacterized protein C1orf226 | None |
| A2RU67 | FAM234B | S16 | ochoa | Protein FAM234B | None |
| A6NHR9 | SMCHD1 | T16 | ochoa | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-) | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments (By similarity). Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin (PubMed:23542155). Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X (By similarity). Required to facilitate Xist RNA spreading (By similarity). Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus (PubMed:23143600). Has ATPase activity; may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation (PubMed:29748383). Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks (PubMed:24790221, PubMed:25294876). Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair (PubMed:25294876). {ECO:0000250|UniProtKB:Q6P5D8, ECO:0000269|PubMed:23143600, ECO:0000269|PubMed:23542155, ECO:0000269|PubMed:24790221, ECO:0000269|PubMed:25294876, ECO:0000269|PubMed:29748383}. |
| A8MQ03 | CYSRT1 | S16 | ochoa | Cysteine-rich tail protein 1 | Component of the stratum corneum that may contribute to epidermal antimicrobial host defenses. {ECO:0000269|PubMed:36804407}. |
| B2RPK0 | HMGB1P1 | Y16 | ochoa | High mobility group protein B1-like 1 (High mobility group protein 1-like 1) (HMG-1L1) | Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}. |
| B5ME19 | EIF3CL | S16 | ochoa | Eukaryotic translation initiation factor 3 subunit C-like protein | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000250|UniProtKB:Q99613}. |
| C9JLW8 | MCRIP1 | T16 | ochoa | Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B) | The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771). {ECO:0000269|PubMed:25728771}. |
| O14558 | HSPB6 | S16 | ochoa|psp | Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) (Heat shock protein family B member 6) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. {ECO:0000269|PubMed:14717697, ECO:0000269|PubMed:19845507, ECO:0000269|PubMed:20843828, ECO:0000269|PubMed:22427880, ECO:0000305, ECO:0000305|PubMed:22794279}. |
| O14683 | TP53I11 | T16 | ochoa | Tumor protein p53-inducible protein 11 (p53-induced gene 11 protein) | None |
| O14924 | RGS12 | S16 | ochoa | Regulator of G-protein signaling 12 (RGS12) | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. {ECO:0000250|UniProtKB:O08774}.; FUNCTION: [Isoform 5]: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. {ECO:0000269|PubMed:12024043}. |
| O14949 | UQCRQ | S16 | ochoa | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000250|UniProtKB:P08525}. |
| O14976 | GAK | S16 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15083 | ERC2 | S16 | ochoa | ERC protein 2 | Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. |
| O15085 | ARHGEF11 | S16 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15372 | EIF3H | S16 | ochoa | Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O43255 | SIAH2 | S16 | psp | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11483518, PubMed:19224863, PubMed:9334332). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11483518, PubMed:19224863, PubMed:22878263, PubMed:9334332). Has some overlapping function with SIAH1 (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1. {ECO:0000250|UniProtKB:Q06986, ECO:0000269|PubMed:11483518, ECO:0000269|PubMed:12411493, ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:28546513, ECO:0000269|PubMed:9334332}. |
| O43310 | CTIF | S16 | ochoa | CBP80/20-dependent translation initiation factor | Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}. |
| O43491 | EPB41L2 | S16 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O60306 | AQR | S16 | ochoa | RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28076346, PubMed:28502770). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16949364, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| O60437 | PPL | T16 | ochoa | Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. {ECO:0000269|PubMed:9412476}. |
| O60508 | CDC40 | S16 | ochoa | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177). Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177). {ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:33220177, ECO:0000269|PubMed:9830021}. |
| O60566 | BUB1B | S16 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O60684 | KPNA6 | S16 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O75381 | PEX14 | T16 | ochoa | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:21525035, ECO:0000269|PubMed:24235149, ECO:0000269|PubMed:28765278, ECO:0000269|PubMed:9653144}. |
| O75607 | NPM3 | S16 | ochoa | Nucleoplasmin-3 | Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:20073534, PubMed:22362753). Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753). Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447). {ECO:0000269|PubMed:15596447, ECO:0000269|PubMed:20073534, ECO:0000269|PubMed:22362753}. |
| O75937 | DNAJC8 | T16 | ochoa | DnaJ homolog subfamily C member 8 (Splicing protein spf31) | Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}. |
| O94782 | USP1 | S16 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O95197 | RTN3 | S16 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| O95810 | CAVIN2 | S16 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| P00439 | PAH | S16 | psp | Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) | Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. {ECO:0000269|PubMed:18460651, ECO:0000269|PubMed:18835579}. |
| P01583 | IL1A | S16 | ochoa | Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1) | Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:26439902). After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex (PubMed:17507369, PubMed:2950091). Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4 (PubMed:17507369). In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways (PubMed:14687581). Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage (PubMed:15679580). In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as a signal for genotoxic stress without loss of cell integrity (PubMed:26439902). {ECO:0000269|PubMed:14687581, ECO:0000269|PubMed:15679580, ECO:0000269|PubMed:17507369, ECO:0000269|PubMed:26439902, ECO:0000269|PubMed:2950091, ECO:0000269|PubMed:3258335}. |
| P02686 | MBP | S16 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P05023 | ATP1A1 | S16 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05387 | RPLP2 | S16 | ochoa | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P05771 | PRKCB | S16 | ochoa | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:36040231}. |
| P06730 | EIF4E | T16 | ochoa | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P07476 | IVL | S16 | ochoa | Involucrin | Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. |
| P07947 | YES1 | Y16 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P09429 | HMGB1 | Y16 | ochoa | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P12682, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:23303669, ECO:0000269|PubMed:25549101, ECO:0000269|PubMed:27362237, ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:34743181, ECO:0000305|PubMed:23446148, ECO:0000305|PubMed:23519706, ECO:0000305|PubMed:23994764, ECO:0000305|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:15014079, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:17803946, ECO:0000269|PubMed:19446504, ECO:0000269|PubMed:23063560, ECO:0000305|PubMed:19360789, ECO:0000305|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250|UniProtKB:P63158, ECO:0000269|PubMed:20819940, ECO:0000269|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250|UniProtKB:P10103, ECO:0000250|UniProtKB:P63158, ECO:0000250|UniProtKB:P63159, ECO:0000269|PubMed:12765338, ECO:0000269|PubMed:15607795, ECO:0000269|PubMed:15944249, ECO:0000269|PubMed:18250463, ECO:0000269|PubMed:18354232, ECO:0000269|PubMed:18631454, ECO:0000269|PubMed:19064698, ECO:0000269|PubMed:19264983, ECO:0000269|PubMed:20547845, ECO:0000269|PubMed:21660935, ECO:0000269|PubMed:22370717, ECO:0000269|PubMed:22473704, ECO:0000269|PubMed:24474694, ECO:0000269|PubMed:24971542, ECO:0000269|PubMed:25660311, ECO:0000269|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:33147444, ECO:0000269|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269|PubMed:34971702}. |
| P0C7M4 | RHOXF2B | S16 | ochoa | Rhox homeobox family member 2B | Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. {ECO:0000269|PubMed:28171660}. |
| P10275 | AR | S16 | psp | Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}. |
| P14136 | GFAP | S16 | ochoa | Glial fibrillary acidic protein (GFAP) | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| P14317 | HCLS1 | T16 | ochoa|psp | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P14649 | MYL6B | S16 | ochoa | Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) | Regulatory light chain of myosin. Does not bind calcium. |
| P15170 | GSPT1 | S16 | ochoa | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog) | GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242). GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site (PubMed:16777602, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:24486019). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269|PubMed:15987998, ECO:0000269|PubMed:16777602, ECO:0000269|PubMed:19417105, ECO:0000269|PubMed:24486019, ECO:0000269|PubMed:2511002, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:30682371}. |
| P15408 | FOSL2 | S16 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P16383 | GCFC2 | S16 | ochoa | Intron Large complex component GCFC2 (GC-rich sequence DNA-binding factor) (GC-rich sequence DNA-binding factor 2) (Transcription factor 9) (TCF-9) | Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693). {ECO:0000269|PubMed:24304693}. |
| P16949 | STMN1 | S16 | ochoa|psp | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P18850 | ATF6 | S16 | ochoa|psp | Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha] | [Cyclic AMP-dependent transcription factor ATF-6 alpha]: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane (PubMed:10564271, PubMed:11158310, PubMed:11779464). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:10564271, PubMed:11158310, PubMed:11779464). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.; FUNCTION: [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR (PubMed:10564271, PubMed:11158310, PubMed:11163209, PubMed:11779464). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') (PubMed:10564271, PubMed:11158310, PubMed:11779464). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (PubMed:10564271, PubMed:11158310, PubMed:11779464). May play a role in foveal development and cone function in the retina (PubMed:26029869). {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11163209, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}. |
| P19086 | GNAZ | S16 | psp | Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. |
| P23588 | EIF4B | S16 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P24539 | ATP5PB | S16 | ochoa | ATP synthase peripheral stalk subunit b, mitochondrial (ATP synthase F(0) complex subunit B1, mitochondrial) (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b) | Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13619, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P25685 | DNAJB1 | S16 | ochoa | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P25788 | PSMA3 | S16 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P26583 | HMGB2 | Y16 | ochoa | High mobility group protein B2 (High mobility group protein 2) (HMG-2) | Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P30681, ECO:0000269|PubMed:11909973, ECO:0000269|PubMed:18413230, ECO:0000269|PubMed:19522541, ECO:0000269|PubMed:19811285, ECO:0000269|PubMed:19965638, ECO:0000269|PubMed:23877675, ECO:0000269|PubMed:7797075, ECO:0000305|PubMed:20123072}. |
| P26599 | PTBP1 | S16 | psp | Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed:14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:21518792, ECO:0000269|PubMed:21518806}. |
| P26678 | PLN | S16 | ochoa|psp | Phospholamban (PLB) | Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (By similarity). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (By similarity). {ECO:0000250|UniProtKB:P61012, ECO:0000250|UniProtKB:P61014, ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725, ECO:0000269|PubMed:28890335}. |
| P27707 | DCK | S16 | ochoa | Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) | Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445). {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:1996353, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20637175}. |
| P28066 | PSMA5 | S16 | ochoa|psp | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P29350 | PTPN6 | T16 | ochoa | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) | Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities (PubMed:21258366, PubMed:9733788). When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events (PubMed:11907092, PubMed:14739280, PubMed:37932456, PubMed:38166031). Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461). Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling (PubMed:34811497, PubMed:38532423). Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A (PubMed:37595871). {ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:11266449, ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:29925997, ECO:0000269|PubMed:34811497, ECO:0000269|PubMed:37595871, ECO:0000269|PubMed:37932456, ECO:0000269|PubMed:38166031, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9065461, ECO:0000269|PubMed:9733788}. |
| P31948 | STIP1 | S16 | ochoa | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P35270 | SPR | S16 | ochoa | Sepiapterin reductase (SPR) (EC 1.1.1.153) | Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. |
| P35610 | SOAT1 | S16 | ochoa | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}. |
| P41091 | EIF2S3 | S16 | ochoa | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P41212 | ETV6 | S16 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P41226 | UBA7 | S16 | ochoa | Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (EC 6.2.1.-) (D8) (Ubiquitin-activating enzyme E1 homolog) | E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation (PubMed:27545325). Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus (PubMed:16254333, PubMed:19073728, PubMed:29056542, PubMed:29743376, PubMed:37722521). For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition (PubMed:20133869). ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling (PubMed:27564865). {ECO:0000269|PubMed:16254333, ECO:0000269|PubMed:19073728, ECO:0000269|PubMed:20133869, ECO:0000269|PubMed:27545325, ECO:0000269|PubMed:27564865, ECO:0000269|PubMed:29056542, ECO:0000269|PubMed:29743376, ECO:0000269|PubMed:37722521}. |
| P42858 | HTT | S16 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P43403 | ZAP70 | S16 | ochoa | Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269|PubMed:11353765, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:1423621, ECO:0000269|PubMed:20135127, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:38614099, ECO:0000269|PubMed:8124727, ECO:0000269|PubMed:8702662, ECO:0000269|PubMed:9489702}. |
| P45985 | MAP2K4 | S16 | ochoa | Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}. |
| P46821 | MAP1B | S16 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P47897 | QARS1 | S16 | ochoa | Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) | Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). {ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}. |
| P49356 | FNTB | S16 | ochoa | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}. |
| P49715 | CEBPA | S16 | ochoa | CCAAT/enhancer-binding protein alpha (C/EBP alpha) | Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:11242107, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation (PubMed:14660596). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:14660596}.; FUNCTION: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. {ECO:0000269|PubMed:20075868}. |
| P50443 | SLC26A2 | S16 | ochoa | Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2) | Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:11448940, PubMed:15294877, PubMed:20219950, PubMed:7923357). Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions (PubMed:20219950). Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity). {ECO:0000250|UniProtKB:Q62273, ECO:0000269|PubMed:11448940, ECO:0000269|PubMed:15294877, ECO:0000269|PubMed:20219950, ECO:0000269|PubMed:7923357}. |
| P51580 | TPMT | T16 | ochoa | Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748, PubMed:657528). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000269|PubMed:18484748, ECO:0000269|PubMed:657528, ECO:0000305}. |
| P51965 | UBE2E1 | S16 | ochoa | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050). {ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}. |
| P52888 | THOP1 | S16 | ochoa | Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}. |
| P53367 | ARFIP1 | T16 | ochoa | Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) | Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}. |
| P54707 | ATP12A | T16 | ochoa | Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump) | The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:11341842, PubMed:7485470, PubMed:8853415, PubMed:9774385). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed:29391451). {ECO:0000250|UniProtKB:Q9Z1W8, ECO:0000269|PubMed:11341842, ECO:0000269|PubMed:29391451, ECO:0000269|PubMed:7485470, ECO:0000269|PubMed:8853415, ECO:0000269|PubMed:9774385}. |
| P55210 | CASP7 | S16 | ochoa | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:11257230, PubMed:11257231, PubMed:11701129, PubMed:15314233, PubMed:16916640, PubMed:17646170, PubMed:18723680, PubMed:19581639, PubMed:8521391, PubMed:8567622, PubMed:8576161, PubMed:9070923). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (PubMed:12824163, PubMed:15314233, PubMed:17697120, PubMed:19581639, PubMed:20566630, PubMed:23650375, PubMed:23897474, PubMed:27032039). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 (PubMed:10497198, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:18723680, PubMed:20566630, PubMed:21555521, PubMed:22184066, PubMed:22451931, PubMed:27889207, PubMed:28863261, PubMed:31586028, PubMed:34156061, PubMed:35338844, PubMed:35446120). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (PubMed:18723680). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (PubMed:21157428). Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 (PubMed:22464733). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) (PubMed:8643593). Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes (PubMed:20159985). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:P97864, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:12824163, ECO:0000269|PubMed:15314233, ECO:0000269|PubMed:16123041, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17646170, ECO:0000269|PubMed:17697120, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:19581639, ECO:0000269|PubMed:20159985, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21157428, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:22184066, ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23897474, ECO:0000269|PubMed:27032039, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:28863261, ECO:0000269|PubMed:31586028, ECO:0000269|PubMed:34156061, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:8521391, ECO:0000269|PubMed:8567622, ECO:0000269|PubMed:8576161, ECO:0000269|PubMed:8643593, ECO:0000269|PubMed:9070923}.; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. {ECO:0000269|PubMed:8521391}. |
| P61011 | SRP54 | S16 | ochoa | Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977). {ECO:0000250|UniProtKB:P61010, ECO:0000269|PubMed:28972538, ECO:0000269|PubMed:29914977, ECO:0000269|PubMed:34020957}. |
| P61158 | ACTR3 | Y16 | ochoa | Actin-related protein 3 (Actin-like protein 3) | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}. |
| P62888 | RPL30 | S16 | ochoa | Large ribosomal subunit protein eL30 (60S ribosomal protein L30) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P62995 | TRA2B | S16 | ochoa | Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
| P78344 | EIF4G2 | S16 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P78347 | GTF2I | S16 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P98175 | RBM10 | Y16 | psp | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000250|UniProtKB:P70501, ECO:0000269|PubMed:18315527, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:28431233}. |
| Q01780 | EXOSC10 | S16 | ochoa | Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250|UniProtKB:P56960, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273, ECO:0000269|PubMed:25632158, ECO:0000269|PubMed:26857222, ECO:0000269|PubMed:31086179, ECO:0000269|PubMed:32830871, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:36912080}. |
| Q01995 | TAGLN | S16 | ochoa | Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha) | Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}. |
| Q05397 | PTK2 | S16 | ochoa | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) | Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation (PubMed:9360983). Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671, ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435, ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594, ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709, ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107, ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981, ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118, ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:9360983}.; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. {ECO:0000269|PubMed:20109444}. |
| Q07960 | ARHGAP1 | T16 | ochoa | Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP) | GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. |
| Q08378 | GOLGA3 | S16 | ochoa | Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160) | Golgi auto-antigen; probably involved in maintaining Golgi structure. |
| Q08495 | DMTN | S16 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q12797 | ASPH | S16 | ochoa | Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) | [Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}.; FUNCTION: [Isoform 8]: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}. |
| Q12815 | TROAP | S16 | ochoa | Tastin (Trophinin-assisting protein) (Trophinin-associated protein) | Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. |
| Q13200 | PSMD2 | S16 | ochoa | 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.; FUNCTION: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. |
| Q13287 | NMI | S16 | ochoa | N-myc-interactor (Nmi) (N-myc and STAT interactor) | Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881, PubMed:9989503). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:29377960, PubMed:9989503). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963). In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000250|UniProtKB:O35309, ECO:0000269|PubMed:10779520, ECO:0000269|PubMed:10950963, ECO:0000269|PubMed:26342464, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:29350881, ECO:0000269|PubMed:9989503}. |
| Q13322 | GRB10 | Y16 | ochoa | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}. |
| Q13492 | PICALM | S16 | ochoa | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:21808019, PubMed:22118466, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:24067654, PubMed:25241929). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}. |
| Q13526 | PIN1 | S16 | psp | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13576 | IQGAP2 | S16 | ochoa | Ras GTPase-activating-like protein IQGAP2 | Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. |
| Q13595 | TRA2A | S16 | ochoa | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Q13630 | GFUS | S16 | ochoa | GDP-L-fucose synthase (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein) (Short-chain dehydrogenase/reductase family 4E member 1) | Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. {ECO:0000269|PubMed:8910301}. |
| Q13671 | RIN1 | S16 | ochoa | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. {ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9208849}. |
| Q13769 | THOC5 | S16 | ochoa | THO complex subunit 5 (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability (PubMed:18974867). Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes (PubMed:23685434). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23685434, ECO:0000269|PubMed:33191911}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. {ECO:0000250|UniProtKB:Q8BKT7}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14166 | TTLL12 | S16 | ochoa | Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12) | Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). {ECO:0000269|PubMed:20162578, ECO:0000269|PubMed:23251473, ECO:0000269|PubMed:28011935}. |
| Q14914 | PTGR1 | Y16 | ochoa | Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74) | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:25619643). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity) (PubMed:25619643). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:25619643). May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). {ECO:0000250|UniProtKB:P97584, ECO:0000250|UniProtKB:Q29073, ECO:0000269|PubMed:25619643}. |
| Q15003 | NCAPH | S16 | ochoa | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:11136719, ECO:0000269|PubMed:27737959}. |
| Q15173 | PPP2R5B | S16 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PP2A B subunit isoform B'-beta) (PP2A B subunit isoform B56-beta) (PP2A B subunit isoform PR61-beta) (PP2A B subunit isoform R5-beta) | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000269|PubMed:21329884}. |
| Q15382 | RHEB | S16 | ochoa | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12869586, PubMed:12906785, PubMed:15340059, PubMed:15854902, PubMed:16098514, PubMed:20381137, PubMed:22819219, PubMed:24529379, PubMed:29416044, PubMed:32470140, PubMed:33157014, PubMed:25816988). In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:29236692, PubMed:33157014). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes (PubMed:24529379). In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059). {ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12842888, ECO:0000269|PubMed:12869586, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22819219, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29416044, ECO:0000269|PubMed:32470140, ECO:0000269|PubMed:33157014}. |
| Q15427 | SF3B4 | Y16 | ochoa | Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932}. |
| Q15750 | TAB1 | S16 | ochoa | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). {ECO:0000269|PubMed:10838074, ECO:0000269|PubMed:11847341, ECO:0000269|PubMed:14592977, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:22307082, ECO:0000269|PubMed:24403530, ECO:0000269|PubMed:25260751, ECO:0000269|PubMed:29229647, ECO:0000269|PubMed:37832545}. |
| Q2VIR3 | EIF2S3B | S16 | ochoa | Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}. |
| Q32MZ4 | LRRFIP1 | S16 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q3MHD2 | LSM12 | S16 | ochoa | Protein LSM12 | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein (PubMed:34362892). Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release (PubMed:34362892). {ECO:0000269|PubMed:34362892}. |
| Q5QGZ9 | CLEC12A | S16 | ochoa | C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Killer cell C-type lectin-like receptor L1) (hKLRL1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371) | Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511, PubMed:39143217). Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation (By similarity). Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals (PubMed:38367667, PubMed:38386511, PubMed:39143217). Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980). Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation (PubMed:14739280, PubMed:16239426, PubMed:34234773). Acts as a pattern-recognition receptor for NETs in neutrophils: specifically recognizes DNA in NETs, leading to inhibit neutrophil activation and limit further NET formation (PubMed:39143217). This regulation is essential for controlling key neutrophil responses and limit NET-mediated inflammatory conditions (By similarity). Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). Binding to monosodium urate crystals also promotes the type I interferon response (By similarity). Acts as an inhibitor of natural killer (NK) cell cytotoxicity (PubMed:15238421). Also acts as an ihibitor of dendritic cell maturation in an IL10-dependent manner (PubMed:16239426). {ECO:0000250|UniProtKB:Q504P2, ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:15238421, ECO:0000269|PubMed:16239426, ECO:0000269|PubMed:31269448, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:36542980, ECO:0000269|PubMed:38367667, ECO:0000269|PubMed:38386511, ECO:0000269|PubMed:39143217}. |
| Q5SVZ6 | ZMYM1 | S16 | ochoa | Zinc finger MYM-type protein 1 | None |
| Q5SW96 | LDLRAP1 | S16 | ochoa | Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein) | Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). {ECO:0000250|UniProtKB:D3ZAR1, ECO:0000269|PubMed:15728179}. |
| Q5T0D9 | TPRG1L | T16 | ochoa | Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) | Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. {ECO:0000250|UniProtKB:A8WCF8}. |
| Q5T4F4 | ZFYVE27 | S16 | ochoa | Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27) | Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport (PubMed:17082457). Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner (PubMed:19289470). Contributes to both the formation and stabilization of the tubular ER network (PubMed:24668814). Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections (PubMed:23969831). Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner (PubMed:21976701). {ECO:0000250|UniProtKB:Q3TXX3, ECO:0000269|PubMed:17082457, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:21976701, ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:24668814}. |
| Q5VT52 | RPRD2 | S16 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VUG0 | SFMBT2 | S16 | ochoa | Scm-like with four MBT domains protein 2 (Scm-like with 4 MBT domains protein 2) | Transcriptional repressor of HOXB13 gene. {ECO:0000269|PubMed:23385818}. |
| Q5VYS4 | MEDAG | S16 | ochoa | Mesenteric estrogen-dependent adipogenesis protein (Activated in W/Wv mouse stomach 3 homolog) (hAWMS3) (Mesenteric estrogen-dependent adipose 4) (MEDA-4) | Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes. {ECO:0000250}. |
| Q6P1L5 | FAM117B | S16 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P2H3 | CEP85 | T16 | ochoa | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. |
| Q6ZMT1 | STAC2 | T16 | ochoa | SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2) | Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}. |
| Q6ZPD9 | DPY19L3 | S16 | ochoa | Protein C-mannosyl-transferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3) | C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW or WxxC consensus sequence (PubMed:26764097, PubMed:29405629). C-mannosylates RSPO1, a Wnt signaling regulator, preferentially at the first Trp residue in the sequence WxxW (PubMed:26764097, PubMed:29405629). C-mannosylates the netrin receptor UNC5A, preferentially at the third tryptophan of WxxWxxWxxC sequence (By similarity). {ECO:0000250|UniProtKB:Q71B07, ECO:0000269|PubMed:26764097, ECO:0000269|PubMed:29405629}.; FUNCTION: [Isoform 2]: Has no C-mannosyltransferase activity. {ECO:0000269|PubMed:29405629}. |
| Q6ZQN7 | SLCO4C1 | S16 | ochoa | Solute carrier organic anion transporter family member 4C1 (SLCO4C1) (OATP-H) (Organic anion transporter M1) (OATP-M1) (Organic anion transporting polypeptide 4C1) (OATP4C1) (Solute carrier family 21 member 20) | Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:19129463). The driving force for this transport activity is currently not known (By similarity). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (By similarity). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker) (PubMed:30865704). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (PubMed:30865704, PubMed:32642843). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity). {ECO:0000250|UniProtKB:Q71MB6, ECO:0000250|UniProtKB:Q8BGD4, ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20610891, ECO:0000269|PubMed:30865704, ECO:0000269|PubMed:32642843}. |
| Q6ZWE6 | PLEKHM3 | T16 | ochoa | Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein) | Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250|UniProtKB:Q8BM47}. |
| Q7L266 | ASRGL1 | S16 | ochoa | Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain] | Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. {ECO:0000269|PubMed:19839645, ECO:0000269|PubMed:27106100}. |
| Q7L4I2 | RSRC2 | T16 | ochoa | Arginine/serine-rich coiled-coil protein 2 | None |
| Q7L9B9 | EEPD1 | S16 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q7LFL8 | CXXC5 | S16 | ochoa | CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF) | May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}. |
| Q7Z3C6 | ATG9A | S16 | ochoa | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
| Q7Z5H3 | ARHGAP22 | S16 | ochoa|psp | Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) | Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}. |
| Q86U86 | PBRM1 | S16 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86WQ0 | NR2C2AP | S16 | ochoa | Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein) | May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. {ECO:0000269|PubMed:12486131}. |
| Q86XK3 | SFR1 | S16 | ochoa | Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog) | Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223). Acts as a transcriptional modulator for ESR1 (PubMed:23874500). {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23874500}. |
| Q86XR7 | TICAM2 | S16 | psp | TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4) | Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). {ECO:0000269|PubMed:16603631, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:22685567, ECO:0000269|PubMed:25385819, ECO:0000269|PubMed:25825441, ECO:0000269|PubMed:30883606}.; FUNCTION: [Isoform 2]: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes. |
| Q8IV56 | PRR15 | S16 | ochoa | Proline-rich protein 15 | May have a role in proliferation and/or differentiation. {ECO:0000250}. |
| Q8IXY8 | PPIL6 | S16 | ochoa | Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIase) (Cyclophilin-like protein PPIL6) (Rotamase PPIL6) | Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. {ECO:0000269|PubMed:20676357}. |
| Q8IY26 | PLPP6 | S16 | ochoa | Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (EC 3.1.3.-) (EC 3.6.1.-) (EC 3.6.1.68) (Lipid phosphatase-related protein-B) (LPRP-B) (PA-PSP) (Phosphatidic acid phosphatase type 2 domain-containing protein 2) (PPAP2 domain-containing protein 2) (Phospholipid phosphatase 6) (Presqualene diphosphate phosphatase) (Type 1 polyisoprenoid diphosphate phosphatase) | Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354). {ECO:0000269|PubMed:16464866, ECO:0000269|PubMed:18930839, ECO:0000269|PubMed:19220020, ECO:0000269|PubMed:20110354, ECO:0000269|PubMed:23568778}. |
| Q8N302 | AGGF1 | T16 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N3K9 | CMYA5 | S16 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N3L3 | TXLNB | T16 | ochoa | Beta-taxilin (Muscle-derived protein 77) (hMDP77) | Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic. {ECO:0000250}. |
| Q8N4L2 | PIP4P2 | S16 | ochoa | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A) | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). {ECO:0000250|UniProtKB:Q9CZX7, ECO:0000269|PubMed:16365287}. |
| Q8N573 | OXR1 | S16 | ochoa | Oxidation resistance protein 1 | May be involved in protection from oxidative damage. {ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142}. |
| Q8N5V2 | NGEF | S16 | ochoa|psp | Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor) | Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}. |
| Q8NEU8 | APPL2 | S16 | ochoa | DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:15016378, PubMed:24879834, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (By similarity) (PubMed:24879834). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negatively regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (By similarity) (PubMed:19433865). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}. |
| Q8TCX5 | RHPN1 | S16 | ochoa | Rhophilin-1 (GTP-Rho-binding protein 1) | Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules. {ECO:0000250|UniProtKB:Q61085}. |
| Q8TE77 | SSH3 | S16 | ochoa | Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}. |
| Q8WVM7 | STAG1 | T16 | ochoa | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
| Q8WW22 | DNAJA4 | S16 | ochoa | DnaJ homolog subfamily A member 4 | None |
| Q8WWH5 | TRUB1 | T16 | ochoa | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q8WXS3 | BAALC | Y16 | ochoa | Brain and acute leukemia cytoplasmic protein | May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A. {ECO:0000250|UniProtKB:Q920K5}. |
| Q8WYL5 | SSH1 | S16 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q92629 | SGCD | S16 | ochoa | Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
| Q92674 | CENPI | T16 | ochoa | Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269|PubMed:12640463, ECO:0000269|PubMed:16622420}. |
| Q92766 | RREB1 | S16 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q969T4 | UBE2E3 | S16 | ochoa | Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. {ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27237050}. |
| Q96A32 | MYL11 | S16 | ochoa | Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform) | Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). {ECO:0000250|UniProtKB:O93409}. |
| Q96AY4 | TTC28 | T16 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96BQ5 | CCDC127 | S16 | ochoa | Coiled-coil domain-containing protein 127 | None |
| Q96CP6 | GRAMD1A | S16 | ochoa | Protein Aster-A (GRAM domain-containing protein 1A) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000269|PubMed:31222192}. |
| Q96CW6 | SLC7A6OS | S16 | ochoa | Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) | Directs RNA polymerase II nuclear import. {ECO:0000250}. |
| Q96DH6 | MSI2 | S16 | ochoa | RNA-binding protein Musashi homolog 2 (Musashi-2) | RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}. |
| Q96EB6 | SIRT1 | S16 | ochoa | NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] | NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17290224, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:20955178, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21947282, PubMed:22274616, PubMed:22918831, PubMed:24415752, PubMed:24824780, PubMed:29681526, PubMed:29765047, PubMed:30409912). Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (PubMed:15469825). Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively (PubMed:14976264, PubMed:14980222, PubMed:15152190). Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction (PubMed:15205477). Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT) (By similarity). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes (PubMed:18485871). The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (PubMed:18485871, PubMed:21504832). Deacetylates 'Lys-266' of SUV39H1, leading to its activation (PubMed:21504832). Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1 (PubMed:19188449). Deacetylates H2A and 'Lys-26' of H1-4 (PubMed:15469825). Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression (PubMed:20375098). Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting (By similarity). Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1 (PubMed:15469825, PubMed:18004385). Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2 (PubMed:18004385, PubMed:21504832). This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response (PubMed:18004385, PubMed:21504832). Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence (PubMed:11672523, PubMed:12006491, PubMed:22542455). Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I (By similarity). Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability (PubMed:19364925, PubMed:21807113). Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation (PubMed:14976264, PubMed:14980222, PubMed:21841822). Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis (PubMed:15126506). Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing (PubMed:21947282). Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha (PubMed:15152190). Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1 (PubMed:17283066, PubMed:17620057, PubMed:20100829, PubMed:20620956). Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver (PubMed:15692560). Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation (PubMed:16892051). Involved in HES1- and HEY2-mediated transcriptional repression (PubMed:12535671). In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62' (PubMed:21698133). Deacetylates MEF2D (PubMed:16166628). Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3 (PubMed:17505061). Represses HNF1A-mediated transcription (By similarity). Required for the repression of ESRRG by CREBZF (PubMed:19690166). Deacetylates NR1H3 and NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteasomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed (PubMed:17936707). Involved in lipid metabolism: deacetylates LPIN1, thereby inhibiting diacylglycerol synthesis (PubMed:20817729, PubMed:29765047). Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2 (By similarity). Deacetylates p300/EP300 and PRMT1 (By similarity). Deacetylates ACSS2 leading to its activation, and HMGCS1 deacetylation (PubMed:21701047). Involved in liver and muscle metabolism. Through deacetylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletal muscle under low-glucose conditions and is involved in glucose homeostasis (PubMed:23142079). Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression (PubMed:17290224, PubMed:20817729). Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and facilitating recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2 (PubMed:15205477, PubMed:16998810, PubMed:17334224, PubMed:17612497, PubMed:20670893, PubMed:21149730). Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN (PubMed:15205477, PubMed:17334224, PubMed:20097625). Promotes DNA double-strand breaks by mediating deacetylation of SIRT6 (PubMed:32538779). Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage (PubMed:18203716). Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1 (PubMed:19934257). Catalyzes deacetylation of ERCC4/XPF, thereby impairing interaction with ERCC1 and nucleotide excision repair (NER) (PubMed:32034146). Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8 (PubMed:18296641). Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation (PubMed:21775285). Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear (PubMed:18687677, PubMed:20203304). In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability (PubMed:21890893). Deacetylates MECOM/EVI1 (PubMed:21555002). Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization (PubMed:22274616). During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling (PubMed:18662546). Deacetylates BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator (By similarity). Deacetylates PER2, facilitating its ubiquitination and degradation by the proteasome (By similarity). Protects cardiomyocytes against palmitate-induced apoptosis (By similarity). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Deacetylates PCK1 and directs its activity toward phosphoenolpyruvate production promoting gluconeogenesis (PubMed:30193097). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). Deacetylates SOX9; promoting SOX9 nuclear localization and transactivation activity (By similarity). Involved in the regulation of centrosome duplication: deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly (PubMed:31722219). Deacetylates NDC80/HEC1 (PubMed:30409912). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating protein delactylation, depropionylation and decrotonylation (PubMed:28497810, PubMed:38512451). Mediates depropionylation of Osterix (SP7) (By similarity). Catalyzes decrotonylation of histones; it however does not represent a major histone decrotonylase (PubMed:28497810). Mediates protein delactylation of TEAD1 and YAP1 (PubMed:38512451). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:22542455, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29681526, ECO:0000269|PubMed:29765047, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:32538779, ECO:0000269|PubMed:38512451}.; FUNCTION: [Isoform 2]: Deacetylates 'Lys-382' of p53/TP53, however with lower activity than isoform 1. In combination, the two isoforms exert an additive effect. Isoform 2 regulates p53/TP53 expression and cellular stress response and is in turn repressed by p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatory loop. {ECO:0000269|PubMed:20975832}.; FUNCTION: [SirtT1 75 kDa fragment]: Catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May be involved in protecting chondrocytes from apoptotic death by associating with cytochrome C and interfering with apoptosome assembly. {ECO:0000269|PubMed:21987377}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}. |
| Q96EZ8 | MCRS1 | S16 | ochoa | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (PubMed:25816988). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (PubMed:22081094, PubMed:27192185). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (PubMed:30785839). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (PubMed:36350698). Regulates G2/M transition and spindle assembly during oocyte meiosis (By similarity). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (By similarity). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (By similarity). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (PubMed:27263857). Required for epiblast development during early embryogenesis (By similarity). Essential for cell viability (PubMed:16547491). {ECO:0000250|UniProtKB:Q99L90, ECO:0000269|PubMed:11948183, ECO:0000269|PubMed:15044100, ECO:0000269|PubMed:16547491, ECO:0000269|PubMed:16571602, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22081094, ECO:0000269|PubMed:25816988, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27263857, ECO:0000269|PubMed:30785839, ECO:0000269|PubMed:36350698}. |
| Q96FW1 | OTUB1 | S16 | ochoa|psp | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (PubMed:12401499, PubMed:12704427, PubMed:14661020, PubMed:23827681). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy (PubMed:14661020). Isoform 1 destabilizes RNF128, leading to prevent anergy (PubMed:14661020). In contrast, isoform 2 stabilizes RNF128 and promotes anergy (PubMed:14661020). Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (PubMed:14661020). Deubiquitinates estrogen receptor alpha (ESR1) (PubMed:19383985). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (PubMed:18954305, PubMed:19211026, PubMed:23827681). Not able to cleave di-ubiquitin (PubMed:18954305, PubMed:23827681). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (PubMed:18954305, PubMed:23827681). {ECO:0000269|PubMed:12401499, ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:14661020, ECO:0000269|PubMed:18954305, ECO:0000269|PubMed:19211026, ECO:0000269|PubMed:19383985, ECO:0000269|PubMed:23827681}.; FUNCTION: Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites (PubMed:20725033, PubMed:22325355). Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks (PubMed:20725033, PubMed:22325355). Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1 (PubMed:20725033, PubMed:22325355). The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain (PubMed:20725033, PubMed:22325355). Acts as a regulator of mTORC1 and mTORC2 complexes (PubMed:29382726, PubMed:35927303). When phosphorylated at Tyr-26, acts as an activator of the mTORC1 complex by mediating deubiquitination of RPTOR via a non-catalytic process: acts by binding and inhibiting the activity of the ubiquitin-conjugating enzyme E2 (UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13), thereby preventing ubiquitination of RPTOR (PubMed:35927303). Can also act as an inhibitor of the mTORC1 and mTORC2 complexes in response to amino acids by mediating non-catalytic deubiquitination of DEPTOR (PubMed:29382726). {ECO:0000269|PubMed:20725033, ECO:0000269|PubMed:22325355, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:35927303}. |
| Q96FZ5 | CMTM7 | S16 | ochoa | CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7) | None |
| Q96GD4 | AURKB | T16 | ochoa | Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11756469, PubMed:11784863, PubMed:11856369, PubMed:12689593, PubMed:14602875, PubMed:16103226, PubMed:21658950). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). Phosphorylates ATXN10 which promotes phosphorylation of ATXN10 by PLK1 and may play a role in the regulation of cytokinesis and stimulating the proteasomal degradation of ATXN10 (PubMed:25666058). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:25666058, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}. |
| Q96GX8 | C16orf74 | S16 | ochoa | Uncharacterized protein C16orf74 | None |
| Q96HU1 | SGSM3 | T16 | ochoa | Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP) | May play a cooperative role in NF2-mediated growth suppression of cells. {ECO:0000269|PubMed:15541357}. |
| Q96MY1 | NOL4L | S16 | ochoa | Nucleolar protein 4-like | None |
| Q96QD9 | FYTTD1 | S16 | ochoa | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}. |
| Q96S97 | MYADM | S16 | ochoa | Myeloid-associated differentiation marker (Protein SB135) | None |
| Q99549 | MPHOSPH8 | S16 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99613 | EIF3C | S16 | ochoa | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q99956 | DUSP9 | S16 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q99966 | CITED1 | S16 | ochoa | Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1) | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:21172805}. |
| Q9BQG0 | MYBBP1A | T16 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BQY4 | RHOXF2 | S16 | ochoa | Rhox homeobox family member 2 (Paired-like homeobox protein PEPP-2) (Testis homeobox gene 1) | Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. {ECO:0000269|PubMed:28171660}. |
| Q9BRT9 | GINS4 | S16 | ochoa | DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:28414293, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}. |
| Q9BSJ6 | PIMREG | S16 | ochoa | Protein PIMREG (CALM-interactor expressed in thymus and spleen) (PICALM-interacting mitotic regulator) (Regulator of chromosome segregation protein 1) | During mitosis, may play a role in the control of metaphase-to-anaphase transition. {ECO:0000269|PubMed:18757745}. |
| Q9BTX7 | TTPAL | S16 | ochoa | Alpha-tocopherol transfer protein-like | May act as a protein that binds a hydrophobic ligand. {ECO:0000305}. |
| Q9BUQ8 | DDX23 | S16 | ochoa | Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) | Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). {ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:28076779}. |
| Q9BUR4 | WRAP53 | S16 | ochoa | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) | RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:20351177, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:27525486, ECO:0000269|PubMed:27715493, ECO:0000269|PubMed:29695869, ECO:0000269|PubMed:29804836}. |
| Q9BVG9 | PTDSS2 | S16 | ochoa | Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II) | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:19014349). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). {ECO:0000250|UniProtKB:Q9Z1X2, ECO:0000269|PubMed:19014349}. |
| Q9BWH2 | FUNDC2 | T16 | ochoa | FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6) | Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281). {ECO:0000269|PubMed:25855506, ECO:0000269|PubMed:29187281, ECO:0000269|PubMed:29786068}. |
| Q9BWQ6 | YIPF2 | T16 | ochoa | Protein YIPF2 (YIP1 family member 2) | None |
| Q9H0G5 | NSRP1 | T16 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
| Q9H2D1 | SLC25A32 | T16 | ochoa | Solute carrier family 25 member 32 (Mitochondrial FAD transporter) | Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis. {ECO:0000269|PubMed:16165386, ECO:0000269|PubMed:29666258, ECO:0000269|PubMed:35727412}. |
| Q9H2G4 | TSPYL2 | S16 | ochoa | Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79) | Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}. |
| Q9H330 | TMEM245 | S16 | ochoa | Transmembrane protein 245 (Protein CG-2) | None |
| Q9H3R5 | CENPH | S16 | ochoa | Centromere protein H (CENP-H) (Interphase centromere complex protein 35) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:14536089, ECO:0000269|PubMed:16875666, ECO:0000269|PubMed:18007590}. |
| Q9H3Y8 | PPDPF | Y16 | ochoa|psp | Pancreatic progenitor cell differentiation and proliferation factor (Exocrine differentiation and proliferation factor) | Probable regulator of exocrine pancreas development. {ECO:0000250}. |
| Q9H4L5 | OSBPL3 | S16 | ochoa | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. |
| Q9H583 | HEATR1 | S16 | ochoa | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:38225354}. |
| Q9H6U8 | ALG9 | S16 | ochoa | Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9 homolog) (Disrupted in bipolar disorder protein 1) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) | Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, catalyzes the addition of the seventh and ninth alpha-1,2-linked mannose residues to Man(6)GlcNAc(2)-PP-dolichol and Man(8)GlcNAc(2)-PP-dolichol respectively. {ECO:0000269|PubMed:15148656, ECO:0000269|PubMed:15945070}. |
| Q9H7J1 | PPP1R3E | S16 | ochoa | Protein phosphatase 1 regulatory subunit 3E | Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis. {ECO:0000269|PubMed:15752363}. |
| Q9H814 | PHAX | S16 | ochoa | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
| Q9H8W4 | PLEKHF2 | S16 | ochoa | Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18) | May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}. |
| Q9HB90 | RRAGC | Y16 | ochoa | Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929) | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:31601708, PubMed:31601764, PubMed:32612235, PubMed:34071043, PubMed:36697823, PubMed:37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279, PubMed:27234373, PubMed:32612235, PubMed:36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279, PubMed:27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235, PubMed:36697823). {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:27234373, ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:34071043, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:37057673}. |
| Q9HC35 | EML4 | S16 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9NRA2 | SLC17A5 | S16 | ochoa | Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT) | Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity) (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (PubMed:22778404). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (By similarity) (PubMed:21781115, PubMed:22778404, PubMed:23889254). {ECO:0000250|UniProtKB:Q5Q0U0, ECO:0000250|UniProtKB:Q8BN82, ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:21781115, ECO:0000269|PubMed:22778404, ECO:0000269|PubMed:23889254}.; FUNCTION: Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. {ECO:0000250|UniProtKB:Q9MZD1}. |
| Q9NRX4 | PHPT1 | S16 | ochoa | 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog) | Exhibits phosphohistidine phosphatase activity. {ECO:0000269|PubMed:19836471, ECO:0000269|PubMed:25574816}. |
| Q9NS37 | CREBZF | S16 | ochoa | CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) | Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}. |
| Q9NS39 | ADARB2 | S16 | ochoa | Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2) | Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA. |
| Q9NUJ3 | TCP11L1 | S16 | ochoa | T-complex protein 11-like protein 1 | None |
| Q9NVC3 | SLC38A7 | S16 | ochoa | Sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7) | Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation (PubMed:28416685, PubMed:35561222). The transport activity requires an acidic lysosomal lumen (PubMed:28416685). {ECO:0000269|PubMed:28416685, ECO:0000269|PubMed:35561222}. |
| Q9NVD7 | PARVA | T16 | ochoa|psp | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}. |
| Q9NWQ4 | GPATCH2L | S16 | ochoa | G patch domain-containing protein 2-like | None |
| Q9NWZ5 | UCKL1 | S16 | ochoa | Uridine-cytidine kinase-like 1 (EC 2.7.1.48) | May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}. |
| Q9NX09 | DDIT4 | S16 | ochoa | DNA damage-inducible transcript 4 protein (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1) | Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. {ECO:0000250, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201, ECO:0000269|PubMed:15988001, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067, ECO:0000269|PubMed:19557001, ECO:0000269|PubMed:20166753, ECO:0000269|PubMed:21460850}. |
| Q9NYN1 | RASL12 | S16 | ochoa | Ras-like protein family member 12 (EC 3.6.5.2) (Ras-like protein Ris) | None |
| Q9NZU5 | LMCD1 | S16 | ochoa | LIM and cysteine-rich domains protein 1 (Dyxin) | Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269|PubMed:20026769}. |
| Q9P258 | RCC2 | S16 | ochoa | Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa) | Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA (PubMed:12919680, PubMed:25074804, PubMed:26158537, PubMed:28869598). Required for normal progress through the cell cycle, both during interphase and during mitosis (PubMed:12919680, PubMed:23388455, PubMed:26158537). Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles (PubMed:12919680, PubMed:26158537). Required for normal organization of the microtubule cytoskeleton in interphase cells (PubMed:23388455). Functions as guanine nucleotide exchange factor (GEF) for RALA (PubMed:26158537). Interferes with the activation of RAC1 by guanine nucleotide exchange factors (PubMed:25074804). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804, PubMed:28869598). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (PubMed:25074804, PubMed:28869598). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:26158537, ECO:0000269|PubMed:28869598}. |
| Q9P2Y4 | ZNF219 | S16 | ochoa | Zinc finger protein 219 | Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}. |
| Q9UBN7 | HDAC6 | S16 | ochoa | Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) | Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532). {ECO:0000250|UniProtKB:D3ZVD8, ECO:0000250|UniProtKB:Q9Z2V5, ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:17846173, ECO:0000269|PubMed:18606987, ECO:0000269|PubMed:20308065, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:24882211, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26246421, ECO:0000269|PubMed:30538141, ECO:0000269|PubMed:30770470, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:38534334, ECO:0000269|PubMed:39567688}.; FUNCTION: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication. {ECO:0000269|PubMed:39135075}. |
| Q9UDV6 | ZNF212 | T16 | ochoa | Zinc finger protein 212 (Zinc finger protein C2H2-150) | May be involved in transcriptional regulation. |
| Q9UHR4 | BAIAP2L1 | Y16 | psp | BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate) | May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Q9UI08 | EVL | Y16 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UIL8 | PHF11 | S16 | ochoa | PHD finger protein 11 (BRCA1 C-terminus-associated protein) (Renal carcinoma antigen NY-REN-34) | Positive regulator of Th1-type cytokine gene expression. {ECO:0000269|PubMed:18405956}. |
| Q9UJF2 | RASAL2 | S16 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKG1 | APPL1 | S16 | ochoa | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
| Q9UKK9 | NUDT5 | Y16 | ochoa | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:17052728, PubMed:19699693, PubMed:21389046). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693, ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}. |
| Q9ULI0 | ATAD2B | S16 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UMX0 | UBQLN1 | S16 | ochoa | Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1) | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:19822669). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804). {ECO:0000250|UniProtKB:Q9JJP9, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:22233804, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:23459205, ECO:0000303|PubMed:15147878}.; FUNCTION: [Isoform 1]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}.; FUNCTION: [Isoform 2]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. {ECO:0000269|PubMed:18953672}.; FUNCTION: [Isoform 3]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}. |
| Q9UN81 | L1RE1 | S16 | ochoa | LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1) | Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11158327, ECO:0000269|PubMed:21937507, ECO:0000269|PubMed:28806172, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:8945518}. |
| Q9UPR0 | PLCL2 | T16 | ochoa | Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}. |
| Q9Y3C1 | NOP16 | S16 | ochoa | Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3) | None |
| Q9Y3Q8 | TSC22D4 | T16 | ochoa | TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}. |
| Q9Y4X0 | AMMECR1 | S16 | ochoa | Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein) | None |
| Q9Y534 | CSDC2 | S16 | ochoa | Cold shock domain-containing protein C2 (RNA-binding protein PIPPin) | RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). {ECO:0000250}. |
| Q9Y5B6 | PAXBP1 | S16 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y5T5 | USP16 | S16 | ochoa | Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:17914355). Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis (PubMed:17914355). In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination (PubMed:17914355). Prefers nucleosomal substrates (PubMed:17914355). Does not deubiquitinate histone H2B (PubMed:17914355). Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit (PubMed:32129764). Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability. {ECO:0000255|HAMAP-Rule:MF_03062, ECO:0000269|PubMed:17914355, ECO:0000269|PubMed:32129764}. |
| Q9Y6D9 | MAD1L1 | S16 | ochoa | Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:36322655}.; FUNCTION: [Isoform 3]: Sequesters MAD2L1 in the cytoplasm preventing its function as an activator of the mitotic spindle assembly checkpoint (SAC) resulting in SAC impairment and chromosomal instability in hepatocellular carcinomas. {ECO:0000269|PubMed:19010891}. |
| P50914 | RPL14 | S16 | Sugiyama | Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| O43813 | LANCL1 | S16 | Sugiyama | Glutathione S-transferase LANCL1 (EC 2.5.1.18) (40 kDa erythrocyte membrane protein) (p40) (LanC-like protein 1) | Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}. |
| Q14790 | CASP8 | S16 | Sugiyama | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250|UniProtKB:O89110, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:18216014, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27109099, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:8681376, ECO:0000269|PubMed:8681377, ECO:0000269|PubMed:8755496, ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9006941, ECO:0000269|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269|PubMed:12010809, ECO:0000305|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305|PubMed:8681376}. |
| O14965 | AURKA | T16 | GPS6|ELM|EPSD|PSP | Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) | Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}. |
| Q9UJU6 | DBNL | Y16 | Sugiyama | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Q13066 | GAGE2B | Y16 | Sugiyama | G antigen 2B/2C (GAGE-2B) (GAGE-2C) (Cancer/testis antigen 4.2) (CT4.2) (G antigen 2C) | Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. |
| Q6NT46 | GAGE2A | Y16 | Sugiyama | G antigen 2A (GAGE-2A) | None |
| Q6QNY0 | BLOC1S3 | T16 | Sugiyama | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:16385460, ECO:0000269|PubMed:17182842}. |
| P35611 | ADD1 | T16 | Sugiyama | Alpha-adducin (Erythrocyte adducin subunit alpha) | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| P61513 | RPL37A | T16 | Sugiyama | Large ribosomal subunit protein eL43 (60S ribosomal protein L37a) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q13371 | PDCL | Y16 | Sugiyama | Phosducin-like protein (PHLP) | Acts as a positive regulator of hedgehog signaling and regulates ciliary function. {ECO:0000250|UniProtKB:Q9DBX2}.; FUNCTION: [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.; FUNCTION: [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin. |
| Q8N8S7 | ENAH | Y16 | Sugiyama | Protein enabled homolog | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}. |
| P20248 | CCNA2 | S16 | Sugiyama | Cyclin-A2 (Cyclin-A) (Cyclin A) | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}. |
| Q15746 | MYLK | S16 | ELM | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| P50552 | VASP | Y16 | Sugiyama | Vasodilator-stimulated phosphoprotein (VASP) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. {ECO:0000269|PubMed:10087267, ECO:0000269|PubMed:10438535, ECO:0000269|PubMed:15939738, ECO:0000269|PubMed:17082196, ECO:0000269|PubMed:18559661}. |
| Q9NZZ3 | CHMP5 | S16 | Sugiyama | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844). {ECO:0000269|PubMed:14519844}. |
| P48163 | ME1 | Y16 | Sugiyama | NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) | Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:7757881, ECO:0000269|PubMed:8187880, ECO:0000269|PubMed:8804575}. |
| P55010 | EIF5 | Y16 | Sugiyama | Eukaryotic translation initiation factor 5 (eIF-5) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}. |
| Q9NZL9 | MAT2B | S16 | Sugiyama | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:23425511, ECO:0000269|PubMed:25075345}. |
| P13984 | GTF2F2 | T16 | Sugiyama | General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. {ECO:0000269|PubMed:2477704}. |
| P51957 | NEK4 | S16 | Sugiyama | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Q9NQP4 | PFDN4 | T16 | Sugiyama | Prefoldin subunit 4 (Protein C-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q9UK45 | LSM7 | S16 | Sugiyama | U6 snRNA-associated Sm-like protein LSm7 | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}. |
| P17987 | TCP1 | T16 | Sugiyama | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q92797 | SYMPK | S16 | Sugiyama | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q9NZB2 | FAM120A | S16 | Sugiyama | Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated SRC activator) (Protein FAM120A) | Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed:19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed:19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed:19015244). {ECO:0000269|PubMed:19015244}. |
| Q9BT78 | COPS4 | S16 | Sugiyama | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
| Q8TF76 | HASPIN | Y16 | Sugiyama | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8IWL2 | SFTPA1 | S16 | Sugiyama | Pulmonary surfactant-associated protein A1 (PSP-A) (PSPA) (SP-A) (SP-A1) (35 kDa pulmonary surfactant-associated protein) (Alveolar proteinosis protein) (Collectin-4) | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity). {ECO:0000250|UniProtKB:P35242}.; FUNCTION: (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928). Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169). {ECO:0000269|PubMed:17158455, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:21203928}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen (PubMed:15845487, PubMed:25139904). When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen (PubMed:25139904). {ECO:0000269|PubMed:15845487, ECO:0000269|PubMed:25139904}. |
| Q9NR20 | DYRK4 | S16 | Sugiyama | Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) | Possible non-essential role in spermiogenesis. {ECO:0000250}. |
| Q8NBT2 | SPC24 | S16 | Sugiyama | Kinetochore protein Spc24 (hSpc24) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:23085020}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 5.924567e-07 | 6.227 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.422483e-06 | 5.847 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.422483e-06 | 5.847 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.612797e-06 | 5.442 |
| R-HSA-2467813 | Separation of Sister Chromatids | 4.802976e-05 | 4.318 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.945907e-05 | 4.226 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.556107e-05 | 4.068 |
| R-HSA-75153 | Apoptotic execution phase | 8.202814e-05 | 4.086 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.219228e-05 | 4.035 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.402341e-04 | 3.853 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.402341e-04 | 3.853 |
| R-HSA-8953854 | Metabolism of RNA | 1.656633e-04 | 3.781 |
| R-HSA-109581 | Apoptosis | 1.756482e-04 | 3.755 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.011575e-04 | 3.696 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.034796e-04 | 3.691 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.302639e-04 | 3.638 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.232826e-04 | 3.651 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.811182e-04 | 3.551 |
| R-HSA-72172 | mRNA Splicing | 3.589004e-04 | 3.445 |
| R-HSA-5357801 | Programmed Cell Death | 3.741275e-04 | 3.427 |
| R-HSA-391160 | Signal regulatory protein family interactions | 3.968754e-04 | 3.401 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.440445e-04 | 3.353 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.440445e-04 | 3.353 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.156840e-04 | 3.381 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.206389e-04 | 3.283 |
| R-HSA-2262752 | Cellular responses to stress | 5.597605e-04 | 3.252 |
| R-HSA-68882 | Mitotic Anaphase | 5.813157e-04 | 3.236 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.042117e-04 | 3.219 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.060198e-04 | 3.151 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 8.058240e-04 | 3.094 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.575394e-04 | 3.067 |
| R-HSA-72766 | Translation | 9.210890e-04 | 3.036 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 9.601499e-04 | 3.018 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 1.015824e-03 | 2.993 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 1.104635e-03 | 2.957 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.104635e-03 | 2.957 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.115214e-03 | 2.953 |
| R-HSA-72649 | Translation initiation complex formation | 1.199282e-03 | 2.921 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 1.300014e-03 | 2.886 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 1.407086e-03 | 2.852 |
| R-HSA-9020702 | Interleukin-1 signaling | 1.356632e-03 | 2.868 |
| R-HSA-446652 | Interleukin-1 family signaling | 1.523198e-03 | 2.817 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.641283e-03 | 2.785 |
| R-HSA-8953897 | Cellular responses to stimuli | 2.122731e-03 | 2.673 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 2.197325e-03 | 2.658 |
| R-HSA-68877 | Mitotic Prometaphase | 2.391071e-03 | 2.621 |
| R-HSA-9675108 | Nervous system development | 2.363044e-03 | 2.627 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.534613e-03 | 2.596 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.534613e-03 | 2.596 |
| R-HSA-422475 | Axon guidance | 2.428375e-03 | 2.615 |
| R-HSA-165159 | MTOR signalling | 2.655027e-03 | 2.576 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.812184e-03 | 2.551 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 3.508005e-03 | 2.455 |
| R-HSA-5689880 | Ub-specific processing proteases | 3.615566e-03 | 2.442 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.087615e-03 | 2.389 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 4.066301e-03 | 2.391 |
| R-HSA-68886 | M Phase | 4.132630e-03 | 2.384 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.949177e-03 | 2.305 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.006652e-03 | 2.300 |
| R-HSA-72187 | mRNA 3'-end processing | 5.691464e-03 | 2.245 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.508990e-03 | 2.186 |
| R-HSA-9711097 | Cellular response to starvation | 6.324920e-03 | 2.199 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.290229e-03 | 2.201 |
| R-HSA-5688426 | Deubiquitination | 6.075352e-03 | 2.216 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.316074e-03 | 2.136 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.511979e-03 | 2.124 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.614135e-03 | 2.118 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 8.318049e-03 | 2.080 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 7.777438e-03 | 2.109 |
| R-HSA-202403 | TCR signaling | 8.537380e-03 | 2.069 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 9.008995e-03 | 2.045 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 1.003513e-02 | 1.998 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 1.003513e-02 | 1.998 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.001630e-02 | 1.999 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 9.628517e-03 | 2.016 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 9.379975e-03 | 2.028 |
| R-HSA-156902 | Peptide chain elongation | 1.031154e-02 | 1.987 |
| R-HSA-1640170 | Cell Cycle | 1.044778e-02 | 1.981 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.182939e-02 | 1.927 |
| R-HSA-202433 | Generation of second messenger molecules | 1.214364e-02 | 1.916 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.214364e-02 | 1.916 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.236856e-02 | 1.908 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.292477e-02 | 1.889 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.469830e-02 | 1.833 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.530288e-02 | 1.815 |
| R-HSA-5687868 | Defective SFTPA2 causes IPF | 1.845817e-02 | 1.734 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.694376e-02 | 1.771 |
| R-HSA-5683826 | Surfactant metabolism | 1.694376e-02 | 1.771 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 1.751427e-02 | 1.757 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 1.829304e-02 | 1.738 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.870505e-02 | 1.728 |
| R-HSA-429947 | Deadenylation of mRNA | 1.913009e-02 | 1.718 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 1.915213e-02 | 1.718 |
| R-HSA-2408557 | Selenocysteine synthesis | 1.948003e-02 | 1.710 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.031993e-02 | 1.692 |
| R-HSA-192823 | Viral mRNA Translation | 2.102014e-02 | 1.677 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.260117e-02 | 1.646 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 2.153066e-02 | 1.667 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.278467e-02 | 1.642 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.278467e-02 | 1.642 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.445656e-02 | 1.612 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.458507e-02 | 1.609 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 2.493829e-02 | 1.603 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.675597e-02 | 1.573 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.680951e-02 | 1.572 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 2.542381e-02 | 1.595 |
| R-HSA-210990 | PECAM1 interactions | 2.857513e-02 | 1.544 |
| R-HSA-69239 | Synthesis of DNA | 2.522606e-02 | 1.598 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.639178e-02 | 1.579 |
| R-HSA-1500931 | Cell-Cell communication | 2.523242e-02 | 1.598 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.267441e-02 | 1.486 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.492652e-02 | 1.457 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 3.657675e-02 | 1.437 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 3.657675e-02 | 1.437 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 3.657675e-02 | 1.437 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 3.657675e-02 | 1.437 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 3.657675e-02 | 1.437 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.776304e-02 | 1.423 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.756568e-02 | 1.425 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 4.215003e-02 | 1.375 |
| R-HSA-69242 | S Phase | 3.756568e-02 | 1.425 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 3.643355e-02 | 1.438 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.196233e-02 | 1.377 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.966490e-02 | 1.402 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.215003e-02 | 1.375 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 4.215003e-02 | 1.375 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.987224e-02 | 1.399 |
| R-HSA-5578995 | Defective TPMT causes TPMT deficiency | 5.436197e-02 | 1.265 |
| R-HSA-3560792 | Defective SLC26A2 causes chondrodysplasias | 5.436197e-02 | 1.265 |
| R-HSA-5619035 | Defective SLC17A5 causes Salla disease (SD) and ISSD | 5.436197e-02 | 1.265 |
| R-HSA-4720454 | Defective ALG9 causes CDG-1l | 7.181994e-02 | 1.144 |
| R-HSA-8854521 | Interaction between PHLDA1 and AURKA | 7.181994e-02 | 1.144 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 4.955933e-02 | 1.305 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 5.426009e-02 | 1.266 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 5.911122e-02 | 1.228 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 5.911122e-02 | 1.228 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 7.988024e-02 | 1.098 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 8.538062e-02 | 1.069 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 8.110338e-02 | 1.091 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 8.110338e-02 | 1.091 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 6.923633e-02 | 1.160 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 5.911122e-02 | 1.228 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 8.538062e-02 | 1.069 |
| R-HSA-9907900 | Proteasome assembly | 7.434903e-02 | 1.129 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.397634e-02 | 1.194 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 4.501624e-02 | 1.347 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.510249e-02 | 1.259 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 8.284751e-02 | 1.082 |
| R-HSA-1433557 | Signaling by SCF-KIT | 7.107042e-02 | 1.148 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.945073e-02 | 1.226 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 7.181994e-02 | 1.144 |
| R-HSA-1433559 | Regulation of KIT signaling | 4.501624e-02 | 1.347 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.630510e-02 | 1.178 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 7.985768e-02 | 1.098 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 7.985768e-02 | 1.098 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 4.955933e-02 | 1.305 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 7.434903e-02 | 1.129 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.358807e-02 | 1.361 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.358807e-02 | 1.361 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 6.410560e-02 | 1.193 |
| R-HSA-8964208 | Phenylalanine metabolism | 8.538062e-02 | 1.069 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.471159e-02 | 1.350 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 6.471595e-02 | 1.189 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 6.471595e-02 | 1.189 |
| R-HSA-8852135 | Protein ubiquitination | 7.109323e-02 | 1.148 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 8.457681e-02 | 1.073 |
| R-HSA-4641258 | Degradation of DVL | 5.006107e-02 | 1.300 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 5.570699e-02 | 1.254 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 6.164224e-02 | 1.210 |
| R-HSA-5689603 | UCH proteinases | 7.355204e-02 | 1.133 |
| R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 7.181994e-02 | 1.144 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 5.426009e-02 | 1.266 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.734886e-02 | 1.325 |
| R-HSA-4641257 | Degradation of AXIN | 5.006107e-02 | 1.300 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 5.006107e-02 | 1.300 |
| R-HSA-432142 | Platelet sensitization by LDL | 6.923633e-02 | 1.160 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.507878e-02 | 1.346 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.510305e-02 | 1.346 |
| R-HSA-169911 | Regulation of Apoptosis | 4.471159e-02 | 1.350 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 6.471595e-02 | 1.189 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 6.471595e-02 | 1.189 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.945073e-02 | 1.226 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 5.945073e-02 | 1.226 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.146157e-02 | 1.289 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 7.566823e-02 | 1.121 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 7.361950e-02 | 1.133 |
| R-HSA-9700206 | Signaling by ALK in cancer | 7.361950e-02 | 1.133 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 5.863892e-02 | 1.232 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 6.164224e-02 | 1.210 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 6.164224e-02 | 1.210 |
| R-HSA-69306 | DNA Replication | 4.285776e-02 | 1.368 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 7.774766e-02 | 1.109 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.734886e-02 | 1.325 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 7.774766e-02 | 1.109 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 5.570699e-02 | 1.254 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 7.107042e-02 | 1.148 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 7.769373e-02 | 1.110 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 7.769373e-02 | 1.110 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.397634e-02 | 1.194 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.397115e-02 | 1.357 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 5.863892e-02 | 1.232 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 6.164224e-02 | 1.210 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 7.769373e-02 | 1.110 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 7.769373e-02 | 1.110 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 7.769373e-02 | 1.110 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.501705e-02 | 1.347 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.613435e-02 | 1.251 |
| R-HSA-4086400 | PCP/CE pathway | 7.859757e-02 | 1.105 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.867749e-02 | 1.163 |
| R-HSA-69541 | Stabilization of p53 | 5.570699e-02 | 1.254 |
| R-HSA-9824272 | Somitogenesis | 7.769373e-02 | 1.110 |
| R-HSA-168255 | Influenza Infection | 7.957014e-02 | 1.099 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.636984e-02 | 1.064 |
| R-HSA-2160456 | Phenylketonuria | 8.895666e-02 | 1.051 |
| R-HSA-75157 | FasL/ CD95L signaling | 8.895666e-02 | 1.051 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.919053e-02 | 1.050 |
| R-HSA-9766229 | Degradation of CDH1 | 9.171020e-02 | 1.038 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 9.315193e-02 | 1.031 |
| R-HSA-6803529 | FGFR2 alternative splicing | 9.670768e-02 | 1.015 |
| R-HSA-8964038 | LDL clearance | 9.670768e-02 | 1.015 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 9.756222e-02 | 1.011 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 9.908414e-02 | 1.004 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 9.908414e-02 | 1.004 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.003723e-01 | 0.998 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 1.222898e-01 | 0.913 |
| R-HSA-68911 | G2 Phase | 1.222898e-01 | 0.913 |
| R-HSA-9652817 | Signaling by MAPK mutants | 1.384977e-01 | 0.859 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.025227e-01 | 0.989 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.519746e-01 | 0.818 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.062870e-01 | 0.974 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.146461e-01 | 0.941 |
| R-HSA-171319 | Telomere Extension By Telomerase | 1.328943e-01 | 0.876 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 1.384977e-01 | 0.859 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.266643e-01 | 0.897 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.066886e-01 | 0.972 |
| R-HSA-391251 | Protein folding | 1.247445e-01 | 0.904 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 1.057780e-01 | 0.976 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 1.434831e-01 | 0.843 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 1.222898e-01 | 0.913 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.384977e-01 | 0.859 |
| R-HSA-1483101 | Synthesis of PS | 1.384977e-01 | 0.859 |
| R-HSA-73886 | Chromosome Maintenance | 1.099985e-01 | 0.959 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 1.384977e-01 | 0.859 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.066886e-01 | 0.972 |
| R-HSA-5578775 | Ion homeostasis | 1.185050e-01 | 0.926 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.247445e-01 | 0.904 |
| R-HSA-74713 | IRS activation | 1.222898e-01 | 0.913 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 1.222898e-01 | 0.913 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.384977e-01 | 0.859 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 1.455540e-01 | 0.837 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.122935e-01 | 0.950 |
| R-HSA-72312 | rRNA processing | 1.018310e-01 | 0.992 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 1.222898e-01 | 0.913 |
| R-HSA-9927353 | Co-inhibition by BTLA | 1.222898e-01 | 0.913 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.521690e-01 | 0.818 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.519746e-01 | 0.818 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.033403e-01 | 0.986 |
| R-HSA-73614 | Pyrimidine salvage | 1.328943e-01 | 0.876 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.028582e-01 | 0.988 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.344493e-01 | 0.871 |
| R-HSA-75158 | TRAIL signaling | 1.384977e-01 | 0.859 |
| R-HSA-69481 | G2/M Checkpoints | 1.282138e-01 | 0.892 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.266217e-01 | 0.897 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 1.478495e-01 | 0.830 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 1.478495e-01 | 0.830 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 1.478495e-01 | 0.830 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.392397e-01 | 0.856 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.509713e-01 | 0.821 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.349701e-01 | 0.870 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.392043e-01 | 0.856 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.434831e-01 | 0.843 |
| R-HSA-5620971 | Pyroptosis | 1.328943e-01 | 0.876 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.066886e-01 | 0.972 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.455540e-01 | 0.837 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.515567e-01 | 0.819 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.515567e-01 | 0.819 |
| R-HSA-9764561 | Regulation of CDH1 Function | 1.225478e-01 | 0.912 |
| R-HSA-351202 | Metabolism of polyamines | 1.349701e-01 | 0.870 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.099985e-01 | 0.959 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 1.392043e-01 | 0.856 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 1.544073e-01 | 0.811 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 1.544073e-01 | 0.811 |
| R-HSA-8964026 | Chylomicron clearance | 1.544073e-01 | 0.811 |
| R-HSA-382556 | ABC-family proteins mediated transport | 1.547366e-01 | 0.810 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.700241e-01 | 0.769 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.700241e-01 | 0.769 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.700241e-01 | 0.769 |
| R-HSA-3371378 | Regulation by c-FLIP | 1.853533e-01 | 0.732 |
| R-HSA-69416 | Dimerization of procaspase-8 | 1.853533e-01 | 0.732 |
| R-HSA-5218900 | CASP8 activity is inhibited | 2.004004e-01 | 0.698 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.004004e-01 | 0.698 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 2.151704e-01 | 0.667 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 2.151704e-01 | 0.667 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 2.296686e-01 | 0.639 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 2.296686e-01 | 0.639 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 2.296686e-01 | 0.639 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.438997e-01 | 0.613 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 2.438997e-01 | 0.613 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 2.438997e-01 | 0.613 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.438997e-01 | 0.613 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.578688e-01 | 0.589 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.578688e-01 | 0.589 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.578688e-01 | 0.589 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.578688e-01 | 0.589 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.578688e-01 | 0.589 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 2.715807e-01 | 0.566 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.982516e-01 | 0.525 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.715480e-01 | 0.766 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.112197e-01 | 0.507 |
| R-HSA-176412 | Phosphorylation of the APC/C | 3.112197e-01 | 0.507 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.112197e-01 | 0.507 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.781627e-01 | 0.749 |
| R-HSA-774815 | Nucleosome assembly | 2.595956e-01 | 0.586 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 2.595956e-01 | 0.586 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.982516e-01 | 0.525 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.611384e-01 | 0.583 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.296686e-01 | 0.639 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.781627e-01 | 0.749 |
| R-HSA-9857492 | Protein lipoylation | 2.982516e-01 | 0.525 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.117462e-01 | 0.674 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 1.584499e-01 | 0.800 |
| R-HSA-3371568 | Attenuation phase | 2.185407e-01 | 0.660 |
| R-HSA-176974 | Unwinding of DNA | 2.004004e-01 | 0.698 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.151704e-01 | 0.667 |
| R-HSA-4839744 | Signaling by APC mutants | 2.296686e-01 | 0.639 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 2.438997e-01 | 0.613 |
| R-HSA-4839735 | Signaling by AXIN mutants | 2.438997e-01 | 0.613 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 2.438997e-01 | 0.613 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.578688e-01 | 0.589 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.578688e-01 | 0.589 |
| R-HSA-9603798 | Class I peroxisomal membrane protein import | 3.112197e-01 | 0.507 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3.007346e-01 | 0.522 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.185407e-01 | 0.660 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.664605e-01 | 0.574 |
| R-HSA-448706 | Interleukin-1 processing | 2.004004e-01 | 0.698 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 2.004004e-01 | 0.698 |
| R-HSA-3371556 | Cellular response to heat stress | 2.452077e-01 | 0.610 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 2.004004e-01 | 0.698 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 2.372257e-01 | 0.625 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 2.372257e-01 | 0.625 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.688609e-01 | 0.772 |
| R-HSA-373752 | Netrin-1 signaling | 2.527329e-01 | 0.597 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 2.151704e-01 | 0.667 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.244670e-01 | 0.649 |
| R-HSA-3371511 | HSF1 activation | 1.915048e-01 | 0.718 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.781627e-01 | 0.749 |
| R-HSA-381042 | PERK regulates gene expression | 1.848163e-01 | 0.733 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.884300e-01 | 0.725 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 2.004004e-01 | 0.698 |
| R-HSA-877312 | Regulation of IFNG signaling | 2.578688e-01 | 0.589 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.075644e-01 | 0.512 |
| R-HSA-9612973 | Autophagy | 2.260946e-01 | 0.646 |
| R-HSA-397014 | Muscle contraction | 2.662036e-01 | 0.575 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.700241e-01 | 0.769 |
| R-HSA-9758890 | Transport of RCbl within the body | 2.296686e-01 | 0.639 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 2.578688e-01 | 0.589 |
| R-HSA-1538133 | G0 and Early G1 | 1.584499e-01 | 0.800 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.296686e-01 | 0.639 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 2.296686e-01 | 0.639 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.715807e-01 | 0.566 |
| R-HSA-174362 | Transport and metabolism of PAPS | 2.982516e-01 | 0.525 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.715480e-01 | 0.766 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.112197e-01 | 0.507 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.871227e-01 | 0.728 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 3.112197e-01 | 0.507 |
| R-HSA-392499 | Metabolism of proteins | 1.574398e-01 | 0.803 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.760884e-01 | 0.754 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 2.004004e-01 | 0.698 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.850401e-01 | 0.545 |
| R-HSA-8963691 | Phenylalanine and tyrosine metabolism | 1.982250e-01 | 0.703 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.593811e-01 | 0.798 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.390236e-01 | 0.622 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.801869e-01 | 0.553 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.075644e-01 | 0.512 |
| R-HSA-156581 | Methylation | 2.527329e-01 | 0.597 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.511986e-01 | 0.600 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 2.175611e-01 | 0.662 |
| R-HSA-74749 | Signal attenuation | 2.151704e-01 | 0.667 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.649757e-01 | 0.783 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.328485e-01 | 0.633 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 2.815514e-01 | 0.550 |
| R-HSA-5218859 | Regulated Necrosis | 1.700170e-01 | 0.770 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 2.004004e-01 | 0.698 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 2.715807e-01 | 0.566 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.850401e-01 | 0.545 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.511986e-01 | 0.600 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.561617e-01 | 0.591 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 2.321824e-01 | 0.634 |
| R-HSA-73893 | DNA Damage Bypass | 2.870439e-01 | 0.542 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 1.715480e-01 | 0.766 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.932876e-01 | 0.714 |
| R-HSA-162582 | Signal Transduction | 1.992967e-01 | 0.700 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.334451e-01 | 0.632 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.791581e-01 | 0.747 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 2.438997e-01 | 0.613 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.117462e-01 | 0.674 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.413173e-01 | 0.617 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.462501e-01 | 0.609 |
| R-HSA-69206 | G1/S Transition | 2.654106e-01 | 0.576 |
| R-HSA-9909396 | Circadian clock | 2.983163e-01 | 0.525 |
| R-HSA-446728 | Cell junction organization | 1.952460e-01 | 0.709 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 3.112197e-01 | 0.507 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.837783e-01 | 0.736 |
| R-HSA-6807070 | PTEN Regulation | 1.683756e-01 | 0.774 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.565735e-01 | 0.805 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.978227e-01 | 0.704 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.146723e-01 | 0.668 |
| R-HSA-5619084 | ABC transporter disorders | 2.169300e-01 | 0.664 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.094797e-01 | 0.679 |
| R-HSA-418990 | Adherens junctions interactions | 2.851105e-01 | 0.545 |
| R-HSA-202424 | Downstream TCR signaling | 2.811591e-01 | 0.551 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.107505e-01 | 0.508 |
| R-HSA-2559583 | Cellular Senescence | 3.138514e-01 | 0.503 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.143811e-01 | 0.503 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.191327e-01 | 0.496 |
| R-HSA-449147 | Signaling by Interleukins | 3.200393e-01 | 0.495 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 3.239490e-01 | 0.490 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.239490e-01 | 0.490 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.239490e-01 | 0.490 |
| R-HSA-6783984 | Glycine degradation | 3.239490e-01 | 0.490 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.239490e-01 | 0.490 |
| R-HSA-157579 | Telomere Maintenance | 3.265944e-01 | 0.486 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.265944e-01 | 0.486 |
| R-HSA-418597 | G alpha (z) signalling events | 3.279682e-01 | 0.484 |
| R-HSA-75893 | TNF signaling | 3.347351e-01 | 0.475 |
| R-HSA-193648 | NRAGE signals death through JNK | 3.347351e-01 | 0.475 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 3.347351e-01 | 0.475 |
| R-HSA-69275 | G2/M Transition | 3.356540e-01 | 0.474 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.364438e-01 | 0.473 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.364438e-01 | 0.473 |
| R-HSA-6787639 | GDP-fucose biosynthesis | 3.364438e-01 | 0.473 |
| R-HSA-5210891 | Uptake and function of anthrax toxins | 3.364438e-01 | 0.473 |
| R-HSA-1632852 | Macroautophagy | 3.400591e-01 | 0.468 |
| R-HSA-913531 | Interferon Signaling | 3.408413e-01 | 0.467 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.414820e-01 | 0.467 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.417679e-01 | 0.466 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.429533e-01 | 0.465 |
| R-HSA-8939211 | ESR-mediated signaling | 3.465814e-01 | 0.460 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 3.482074e-01 | 0.458 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 3.487084e-01 | 0.458 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 3.487084e-01 | 0.458 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.487084e-01 | 0.458 |
| R-HSA-111471 | Apoptotic factor-mediated response | 3.487084e-01 | 0.458 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 3.487084e-01 | 0.458 |
| R-HSA-428643 | Organic anion transport by SLC5/17/25 transporters | 3.487084e-01 | 0.458 |
| R-HSA-2142700 | Biosynthesis of Lipoxins (LX) | 3.487084e-01 | 0.458 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 3.487084e-01 | 0.458 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.518711e-01 | 0.454 |
| R-HSA-180786 | Extension of Telomeres | 3.549098e-01 | 0.450 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 3.568354e-01 | 0.448 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 3.607471e-01 | 0.443 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.607471e-01 | 0.443 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 3.607471e-01 | 0.443 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 3.607471e-01 | 0.443 |
| R-HSA-912631 | Regulation of signaling by CBL | 3.607471e-01 | 0.443 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 3.615878e-01 | 0.442 |
| R-HSA-8956321 | Nucleotide salvage | 3.682398e-01 | 0.434 |
| R-HSA-450294 | MAP kinase activation | 3.682398e-01 | 0.434 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.720181e-01 | 0.429 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 3.725640e-01 | 0.429 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.725640e-01 | 0.429 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 3.725640e-01 | 0.429 |
| R-HSA-9629569 | Protein hydroxylation | 3.725640e-01 | 0.429 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 3.841632e-01 | 0.415 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.841632e-01 | 0.415 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 3.880281e-01 | 0.411 |
| R-HSA-421270 | Cell-cell junction organization | 3.926612e-01 | 0.406 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 3.945641e-01 | 0.404 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.955486e-01 | 0.403 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.955486e-01 | 0.403 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.955486e-01 | 0.403 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.978700e-01 | 0.400 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 3.986962e-01 | 0.399 |
| R-HSA-73887 | Death Receptor Signaling | 3.986962e-01 | 0.399 |
| R-HSA-6798695 | Neutrophil degranulation | 3.999002e-01 | 0.398 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 4.067242e-01 | 0.391 |
| R-HSA-350054 | Notch-HLH transcription pathway | 4.067242e-01 | 0.391 |
| R-HSA-9669938 | Signaling by KIT in disease | 4.067242e-01 | 0.391 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 4.067242e-01 | 0.391 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 4.067242e-01 | 0.391 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.067242e-01 | 0.391 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.091330e-01 | 0.388 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 4.128883e-01 | 0.384 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 4.176939e-01 | 0.379 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 4.176939e-01 | 0.379 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 4.176939e-01 | 0.379 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 4.176939e-01 | 0.379 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.176939e-01 | 0.379 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.176939e-01 | 0.379 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.216767e-01 | 0.375 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.236139e-01 | 0.373 |
| R-HSA-448424 | Interleukin-17 signaling | 4.267458e-01 | 0.370 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 4.284614e-01 | 0.368 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 4.284614e-01 | 0.368 |
| R-HSA-9865881 | Complex III assembly | 4.284614e-01 | 0.368 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 4.284614e-01 | 0.368 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.284614e-01 | 0.368 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 4.284614e-01 | 0.368 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.330757e-01 | 0.363 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 4.330757e-01 | 0.363 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.390305e-01 | 0.358 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 4.390305e-01 | 0.358 |
| R-HSA-2160916 | Hyaluronan degradation | 4.390305e-01 | 0.358 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.390305e-01 | 0.358 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.390305e-01 | 0.358 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 4.456224e-01 | 0.351 |
| R-HSA-8874081 | MET activates PTK2 signaling | 4.494048e-01 | 0.347 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.494048e-01 | 0.347 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.494048e-01 | 0.347 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 4.518376e-01 | 0.345 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.518376e-01 | 0.345 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.580131e-01 | 0.339 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.595878e-01 | 0.338 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.595878e-01 | 0.338 |
| R-HSA-8949613 | Cristae formation | 4.595878e-01 | 0.338 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.595878e-01 | 0.338 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 4.595878e-01 | 0.338 |
| R-HSA-9020591 | Interleukin-12 signaling | 4.641483e-01 | 0.333 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 4.695831e-01 | 0.328 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 4.695831e-01 | 0.328 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.695831e-01 | 0.328 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.695831e-01 | 0.328 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.695831e-01 | 0.328 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 4.695831e-01 | 0.328 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.701343e-01 | 0.328 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.702426e-01 | 0.328 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.748740e-01 | 0.323 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 4.762953e-01 | 0.322 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 4.762953e-01 | 0.322 |
| R-HSA-6783783 | Interleukin-10 signaling | 4.762953e-01 | 0.322 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.762953e-01 | 0.322 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.793942e-01 | 0.319 |
| R-HSA-72086 | mRNA Capping | 4.793942e-01 | 0.319 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.793942e-01 | 0.319 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.793942e-01 | 0.319 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.842947e-01 | 0.315 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.842947e-01 | 0.315 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.842947e-01 | 0.315 |
| R-HSA-162906 | HIV Infection | 4.879426e-01 | 0.312 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.882739e-01 | 0.311 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.890243e-01 | 0.311 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.890243e-01 | 0.311 |
| R-HSA-112311 | Neurotransmitter clearance | 4.890243e-01 | 0.311 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.941989e-01 | 0.306 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.984769e-01 | 0.302 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.984769e-01 | 0.302 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.984769e-01 | 0.302 |
| R-HSA-4791275 | Signaling by WNT in cancer | 5.077553e-01 | 0.294 |
| R-HSA-69190 | DNA strand elongation | 5.077553e-01 | 0.294 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.117110e-01 | 0.291 |
| R-HSA-5576891 | Cardiac conduction | 5.166095e-01 | 0.287 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.168625e-01 | 0.287 |
| R-HSA-9930044 | Nuclear RNA decay | 5.168625e-01 | 0.287 |
| R-HSA-354192 | Integrin signaling | 5.168625e-01 | 0.287 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.168625e-01 | 0.287 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 5.168625e-01 | 0.287 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 5.168625e-01 | 0.287 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.168625e-01 | 0.287 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.168625e-01 | 0.287 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.168625e-01 | 0.287 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.168625e-01 | 0.287 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.199661e-01 | 0.284 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.258018e-01 | 0.279 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.258018e-01 | 0.279 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.343772e-01 | 0.272 |
| R-HSA-447115 | Interleukin-12 family signaling | 5.344337e-01 | 0.272 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.345762e-01 | 0.272 |
| R-HSA-5673000 | RAF activation | 5.345762e-01 | 0.272 |
| R-HSA-2142845 | Hyaluronan metabolism | 5.345762e-01 | 0.272 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 5.345762e-01 | 0.272 |
| R-HSA-203615 | eNOS activation | 5.345762e-01 | 0.272 |
| R-HSA-5205647 | Mitophagy | 5.345762e-01 | 0.272 |
| R-HSA-9663891 | Selective autophagy | 5.400005e-01 | 0.268 |
| R-HSA-983712 | Ion channel transport | 5.428921e-01 | 0.265 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 5.431888e-01 | 0.265 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 5.431888e-01 | 0.265 |
| R-HSA-9682385 | FLT3 signaling in disease | 5.516425e-01 | 0.258 |
| R-HSA-114604 | GPVI-mediated activation cascade | 5.516425e-01 | 0.258 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 5.516425e-01 | 0.258 |
| R-HSA-8853659 | RET signaling | 5.516425e-01 | 0.258 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 5.516425e-01 | 0.258 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.521736e-01 | 0.258 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 5.535883e-01 | 0.257 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.564106e-01 | 0.255 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 5.564236e-01 | 0.255 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 5.599403e-01 | 0.252 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 5.599403e-01 | 0.252 |
| R-HSA-196757 | Metabolism of folate and pterines | 5.599403e-01 | 0.252 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.608209e-01 | 0.251 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.608209e-01 | 0.251 |
| R-HSA-9664407 | Parasite infection | 5.608209e-01 | 0.251 |
| R-HSA-73894 | DNA Repair | 5.639563e-01 | 0.249 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.671397e-01 | 0.246 |
| R-HSA-8875878 | MET promotes cell motility | 5.680851e-01 | 0.246 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 5.680851e-01 | 0.246 |
| R-HSA-74217 | Purine salvage | 5.680851e-01 | 0.246 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 5.680851e-01 | 0.246 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 5.680851e-01 | 0.246 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.760796e-01 | 0.240 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 5.760796e-01 | 0.240 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 5.760796e-01 | 0.240 |
| R-HSA-9648002 | RAS processing | 5.760796e-01 | 0.240 |
| R-HSA-3781860 | Diseases associated with N-glycosylation of proteins | 5.760796e-01 | 0.240 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 5.760796e-01 | 0.240 |
| R-HSA-201556 | Signaling by ALK | 5.760796e-01 | 0.240 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.834141e-01 | 0.234 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 5.839266e-01 | 0.234 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.839266e-01 | 0.234 |
| R-HSA-167169 | HIV Transcription Elongation | 5.839266e-01 | 0.234 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.839266e-01 | 0.234 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 5.839266e-01 | 0.234 |
| R-HSA-9646399 | Aggrephagy | 5.839266e-01 | 0.234 |
| R-HSA-5260271 | Diseases of Immune System | 5.839266e-01 | 0.234 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.839266e-01 | 0.234 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 5.839266e-01 | 0.234 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.839266e-01 | 0.234 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.916288e-01 | 0.228 |
| R-HSA-9607240 | FLT3 Signaling | 5.916288e-01 | 0.228 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.916288e-01 | 0.228 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 5.916288e-01 | 0.228 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.931088e-01 | 0.227 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.981016e-01 | 0.223 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 5.991889e-01 | 0.222 |
| R-HSA-167161 | HIV Transcription Initiation | 5.991889e-01 | 0.222 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 5.991889e-01 | 0.222 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.991889e-01 | 0.222 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 5.991889e-01 | 0.222 |
| R-HSA-74160 | Gene expression (Transcription) | 6.008327e-01 | 0.221 |
| R-HSA-9758941 | Gastrulation | 6.025101e-01 | 0.220 |
| R-HSA-190236 | Signaling by FGFR | 6.031668e-01 | 0.220 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 6.066095e-01 | 0.217 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.081252e-01 | 0.216 |
| R-HSA-1280218 | Adaptive Immune System | 6.137875e-01 | 0.212 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 6.138932e-01 | 0.212 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 6.138932e-01 | 0.212 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.170176e-01 | 0.210 |
| R-HSA-3214858 | RMTs methylate histone arginines | 6.210425e-01 | 0.207 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 6.210425e-01 | 0.207 |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | 6.210425e-01 | 0.207 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 6.210425e-01 | 0.207 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.231285e-01 | 0.205 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 6.280598e-01 | 0.202 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 6.280598e-01 | 0.202 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.280598e-01 | 0.202 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 6.280598e-01 | 0.202 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 6.280598e-01 | 0.202 |
| R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... | 6.339352e-01 | 0.198 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.349476e-01 | 0.197 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.349476e-01 | 0.197 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.349476e-01 | 0.197 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.349476e-01 | 0.197 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 6.349476e-01 | 0.197 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.366447e-01 | 0.196 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 6.417082e-01 | 0.193 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 6.417082e-01 | 0.193 |
| R-HSA-418346 | Platelet homeostasis | 6.461021e-01 | 0.190 |
| R-HSA-9634597 | GPER1 signaling | 6.483441e-01 | 0.188 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 6.483441e-01 | 0.188 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 6.548575e-01 | 0.184 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.548575e-01 | 0.184 |
| R-HSA-8951664 | Neddylation | 6.578904e-01 | 0.182 |
| R-HSA-9748787 | Azathioprine ADME | 6.612506e-01 | 0.180 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 6.612506e-01 | 0.180 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.613029e-01 | 0.180 |
| R-HSA-9658195 | Leishmania infection | 6.613029e-01 | 0.180 |
| R-HSA-2514856 | The phototransduction cascade | 6.675257e-01 | 0.176 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 6.681395e-01 | 0.175 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.736849e-01 | 0.172 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 6.736849e-01 | 0.172 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 6.736849e-01 | 0.172 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.797304e-01 | 0.168 |
| R-HSA-1221632 | Meiotic synapsis | 6.797304e-01 | 0.168 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.797304e-01 | 0.168 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.811151e-01 | 0.167 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 6.914854e-01 | 0.160 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.934980e-01 | 0.159 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.972053e-01 | 0.157 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 6.981800e-01 | 0.156 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.028164e-01 | 0.153 |
| R-HSA-5693538 | Homology Directed Repair | 7.054825e-01 | 0.152 |
| R-HSA-195721 | Signaling by WNT | 7.073255e-01 | 0.150 |
| R-HSA-6782135 | Dual incision in TC-NER | 7.083239e-01 | 0.150 |
| R-HSA-9033241 | Peroxisomal protein import | 7.137296e-01 | 0.146 |
| R-HSA-191859 | snRNP Assembly | 7.137296e-01 | 0.146 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.137296e-01 | 0.146 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 7.137296e-01 | 0.146 |
| R-HSA-4085001 | Sialic acid metabolism | 7.137296e-01 | 0.146 |
| R-HSA-157118 | Signaling by NOTCH | 7.146008e-01 | 0.146 |
| R-HSA-379724 | tRNA Aminoacylation | 7.190355e-01 | 0.143 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.190355e-01 | 0.143 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.190355e-01 | 0.143 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.190355e-01 | 0.143 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.190355e-01 | 0.143 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.190355e-01 | 0.143 |
| R-HSA-1227986 | Signaling by ERBB2 | 7.190355e-01 | 0.143 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.242434e-01 | 0.140 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.282828e-01 | 0.138 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.293551e-01 | 0.137 |
| R-HSA-9707616 | Heme signaling | 7.293551e-01 | 0.137 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 7.293551e-01 | 0.137 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 7.343723e-01 | 0.134 |
| R-HSA-373755 | Semaphorin interactions | 7.343723e-01 | 0.134 |
| R-HSA-194138 | Signaling by VEGF | 7.355445e-01 | 0.133 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 7.392968e-01 | 0.131 |
| R-HSA-74751 | Insulin receptor signalling cascade | 7.392968e-01 | 0.131 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 7.441303e-01 | 0.128 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 7.488745e-01 | 0.126 |
| R-HSA-5693606 | DNA Double Strand Break Response | 7.535310e-01 | 0.123 |
| R-HSA-167172 | Transcription of the HIV genome | 7.581015e-01 | 0.120 |
| R-HSA-9843745 | Adipogenesis | 7.596729e-01 | 0.119 |
| R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis | 7.596729e-01 | 0.119 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.662087e-01 | 0.116 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 7.669905e-01 | 0.115 |
| R-HSA-382551 | Transport of small molecules | 7.710164e-01 | 0.113 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.713122e-01 | 0.113 |
| R-HSA-8978934 | Metabolism of cofactors | 7.713122e-01 | 0.113 |
| R-HSA-168249 | Innate Immune System | 7.728824e-01 | 0.112 |
| R-HSA-74259 | Purine catabolism | 7.755540e-01 | 0.110 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.838037e-01 | 0.106 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.878145e-01 | 0.104 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.917512e-01 | 0.101 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 7.937438e-01 | 0.100 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.983164e-01 | 0.098 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 7.994075e-01 | 0.097 |
| R-HSA-191273 | Cholesterol biosynthesis | 7.994075e-01 | 0.097 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.994610e-01 | 0.097 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 7.994610e-01 | 0.097 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 8.031297e-01 | 0.095 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 8.067831e-01 | 0.093 |
| R-HSA-6806834 | Signaling by MET | 8.067831e-01 | 0.093 |
| R-HSA-9833482 | PKR-mediated signaling | 8.067831e-01 | 0.093 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.097975e-01 | 0.092 |
| R-HSA-977225 | Amyloid fiber formation | 8.103690e-01 | 0.091 |
| R-HSA-597592 | Post-translational protein modification | 8.165615e-01 | 0.088 |
| R-HSA-1266738 | Developmental Biology | 8.177590e-01 | 0.087 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 8.207334e-01 | 0.086 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.209505e-01 | 0.086 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.209505e-01 | 0.086 |
| R-HSA-1500620 | Meiosis | 8.240612e-01 | 0.084 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 8.273274e-01 | 0.082 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.284633e-01 | 0.082 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 8.305331e-01 | 0.081 |
| R-HSA-1989781 | PPARA activates gene expression | 8.333133e-01 | 0.079 |
| R-HSA-70268 | Pyruvate metabolism | 8.336796e-01 | 0.079 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.367678e-01 | 0.077 |
| R-HSA-162587 | HIV Life Cycle | 8.380396e-01 | 0.077 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 8.380396e-01 | 0.077 |
| R-HSA-168256 | Immune System | 8.405115e-01 | 0.075 |
| R-HSA-5668914 | Diseases of metabolism | 8.422311e-01 | 0.075 |
| R-HSA-74752 | Signaling by Insulin receptor | 8.513723e-01 | 0.070 |
| R-HSA-2029481 | FCGR activation | 8.541330e-01 | 0.068 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 8.541330e-01 | 0.068 |
| R-HSA-15869 | Metabolism of nucleotides | 8.566577e-01 | 0.067 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.568427e-01 | 0.067 |
| R-HSA-5619102 | SLC transporter disorders | 8.599022e-01 | 0.066 |
| R-HSA-9824446 | Viral Infection Pathways | 8.655430e-01 | 0.063 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.671886e-01 | 0.062 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.696564e-01 | 0.061 |
| R-HSA-3214847 | HATs acetylate histones | 8.720786e-01 | 0.059 |
| R-HSA-9614085 | FOXO-mediated transcription | 8.720786e-01 | 0.059 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.720786e-01 | 0.059 |
| R-HSA-212436 | Generic Transcription Pathway | 8.724261e-01 | 0.059 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.735672e-01 | 0.059 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.735672e-01 | 0.059 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.767891e-01 | 0.057 |
| R-HSA-199991 | Membrane Trafficking | 8.783002e-01 | 0.056 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.790791e-01 | 0.056 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.790791e-01 | 0.056 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.835327e-01 | 0.054 |
| R-HSA-9833110 | RSV-host interactions | 8.856978e-01 | 0.053 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 8.899084e-01 | 0.051 |
| R-HSA-3781865 | Diseases of glycosylation | 8.925854e-01 | 0.049 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.939643e-01 | 0.049 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.939643e-01 | 0.049 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.978714e-01 | 0.047 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 9.016349e-01 | 0.045 |
| R-HSA-5617833 | Cilium Assembly | 9.018069e-01 | 0.045 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.047134e-01 | 0.043 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 9.052602e-01 | 0.043 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.061364e-01 | 0.043 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 9.070225e-01 | 0.042 |
| R-HSA-1643685 | Disease | 9.072585e-01 | 0.042 |
| R-HSA-909733 | Interferon alpha/beta signaling | 9.104499e-01 | 0.041 |
| R-HSA-9007101 | Rab regulation of trafficking | 9.137513e-01 | 0.039 |
| R-HSA-1592230 | Mitochondrial biogenesis | 9.137513e-01 | 0.039 |
| R-HSA-68875 | Mitotic Prophase | 9.184773e-01 | 0.037 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 9.229452e-01 | 0.035 |
| R-HSA-6805567 | Keratinization | 9.240840e-01 | 0.034 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 9.285250e-01 | 0.032 |
| R-HSA-114608 | Platelet degranulation | 9.298559e-01 | 0.032 |
| R-HSA-8956319 | Nucleotide catabolism | 9.324439e-01 | 0.030 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 9.337020e-01 | 0.030 |
| R-HSA-1474165 | Reproduction | 9.349368e-01 | 0.029 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 9.440243e-01 | 0.025 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.459070e-01 | 0.024 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.475642e-01 | 0.023 |
| R-HSA-3247509 | Chromatin modifying enzymes | 9.507349e-01 | 0.022 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 9.509314e-01 | 0.022 |
| R-HSA-112316 | Neuronal System | 9.510984e-01 | 0.022 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.529923e-01 | 0.021 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.530129e-01 | 0.021 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.531389e-01 | 0.021 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.544421e-01 | 0.020 |
| R-HSA-2187338 | Visual phototransduction | 9.544898e-01 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 9.555625e-01 | 0.020 |
| R-HSA-2142753 | Arachidonate metabolism | 9.585782e-01 | 0.018 |
| R-HSA-9609507 | Protein localization | 9.593509e-01 | 0.018 |
| R-HSA-4839726 | Chromatin organization | 9.610736e-01 | 0.017 |
| R-HSA-877300 | Interferon gamma signaling | 9.636942e-01 | 0.016 |
| R-HSA-9006936 | Signaling by TGFB family members | 9.643718e-01 | 0.016 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.650237e-01 | 0.015 |
| R-HSA-5663205 | Infectious disease | 9.656942e-01 | 0.015 |
| R-HSA-418555 | G alpha (s) signalling events | 9.715828e-01 | 0.013 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.733326e-01 | 0.012 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 9.736472e-01 | 0.012 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.748423e-01 | 0.011 |
| R-HSA-611105 | Respiratory electron transport | 9.750968e-01 | 0.011 |
| R-HSA-9679506 | SARS-CoV Infections | 9.833407e-01 | 0.007 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.844648e-01 | 0.007 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.871397e-01 | 0.006 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.882084e-01 | 0.005 |
| R-HSA-9748784 | Drug ADME | 9.885189e-01 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.894723e-01 | 0.005 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 9.923311e-01 | 0.003 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.951033e-01 | 0.002 |
| R-HSA-418594 | G alpha (i) signalling events | 9.971581e-01 | 0.001 |
| R-HSA-1483257 | Phospholipid metabolism | 9.973325e-01 | 0.001 |
| R-HSA-109582 | Hemostasis | 9.976631e-01 | 0.001 |
| R-HSA-1474244 | Extracellular matrix organization | 9.986552e-01 | 0.001 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.987509e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.991978e-01 | 0.000 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.995720e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.996174e-01 | 0.000 |
| R-HSA-8978868 | Fatty acid metabolism | 9.996908e-01 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 9.997680e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999998e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.889 | 0.413 | 1 | 0.856 |
MOS |
0.878 | 0.234 | 1 | 0.834 |
DYRK2 |
0.878 | 0.383 | 1 | 0.826 |
COT |
0.877 | 0.173 | 2 | 0.833 |
HIPK4 |
0.875 | 0.342 | 1 | 0.841 |
SRPK1 |
0.873 | 0.285 | -3 | 0.796 |
NLK |
0.873 | 0.254 | 1 | 0.861 |
SKMLCK |
0.872 | 0.233 | -2 | 0.901 |
CDKL1 |
0.872 | 0.195 | -3 | 0.834 |
PIM3 |
0.871 | 0.173 | -3 | 0.868 |
JNK2 |
0.871 | 0.357 | 1 | 0.746 |
ICK |
0.871 | 0.270 | -3 | 0.866 |
CDC7 |
0.870 | 0.109 | 1 | 0.805 |
ERK5 |
0.870 | 0.220 | 1 | 0.851 |
PRPK |
0.869 | -0.020 | -1 | 0.852 |
HIPK2 |
0.869 | 0.385 | 1 | 0.760 |
HIPK1 |
0.869 | 0.363 | 1 | 0.832 |
CLK2 |
0.869 | 0.381 | -3 | 0.793 |
CDKL5 |
0.869 | 0.224 | -3 | 0.827 |
CAMK1B |
0.867 | 0.104 | -3 | 0.871 |
CAMLCK |
0.865 | 0.131 | -2 | 0.871 |
JNK3 |
0.865 | 0.323 | 1 | 0.771 |
MTOR |
0.864 | 0.073 | 1 | 0.769 |
P38B |
0.864 | 0.334 | 1 | 0.774 |
DYRK4 |
0.864 | 0.371 | 1 | 0.771 |
DAPK2 |
0.863 | 0.121 | -3 | 0.878 |
CLK4 |
0.863 | 0.283 | -3 | 0.802 |
GRK1 |
0.863 | 0.217 | -2 | 0.807 |
P38A |
0.863 | 0.316 | 1 | 0.808 |
BMPR2 |
0.863 | -0.110 | -2 | 0.872 |
ATR |
0.863 | 0.015 | 1 | 0.765 |
RSK2 |
0.862 | 0.185 | -3 | 0.806 |
PRKD1 |
0.862 | 0.193 | -3 | 0.851 |
PIM1 |
0.862 | 0.169 | -3 | 0.818 |
BMPR1B |
0.862 | 0.196 | 1 | 0.778 |
NDR2 |
0.862 | 0.153 | -3 | 0.863 |
RAF1 |
0.862 | -0.053 | 1 | 0.768 |
CDK1 |
0.861 | 0.303 | 1 | 0.766 |
NIK |
0.861 | 0.021 | -3 | 0.880 |
CDK18 |
0.860 | 0.326 | 1 | 0.737 |
P38G |
0.860 | 0.312 | 1 | 0.700 |
KIS |
0.859 | 0.311 | 1 | 0.800 |
CLK1 |
0.859 | 0.284 | -3 | 0.777 |
CDK8 |
0.859 | 0.266 | 1 | 0.769 |
WNK1 |
0.858 | 0.056 | -2 | 0.897 |
DYRK1A |
0.858 | 0.301 | 1 | 0.815 |
P90RSK |
0.857 | 0.144 | -3 | 0.814 |
ERK1 |
0.857 | 0.296 | 1 | 0.756 |
LATS1 |
0.857 | 0.155 | -3 | 0.868 |
NUAK2 |
0.857 | 0.083 | -3 | 0.868 |
PRKD2 |
0.857 | 0.175 | -3 | 0.805 |
CHAK2 |
0.857 | 0.027 | -1 | 0.829 |
CDK5 |
0.857 | 0.278 | 1 | 0.790 |
PDHK4 |
0.856 | -0.218 | 1 | 0.794 |
CDK7 |
0.856 | 0.262 | 1 | 0.782 |
SRPK3 |
0.856 | 0.188 | -3 | 0.768 |
PKN3 |
0.856 | 0.039 | -3 | 0.855 |
CAMK2G |
0.856 | -0.060 | 2 | 0.786 |
MAK |
0.856 | 0.371 | -2 | 0.808 |
DYRK3 |
0.856 | 0.315 | 1 | 0.834 |
IKKB |
0.856 | -0.027 | -2 | 0.742 |
HIPK3 |
0.855 | 0.304 | 1 | 0.807 |
CDK19 |
0.855 | 0.280 | 1 | 0.743 |
SRPK2 |
0.855 | 0.217 | -3 | 0.724 |
DSTYK |
0.855 | -0.051 | 2 | 0.850 |
RIPK3 |
0.855 | -0.006 | 3 | 0.728 |
TGFBR1 |
0.855 | 0.107 | -2 | 0.816 |
MST4 |
0.854 | 0.050 | 2 | 0.800 |
AURC |
0.854 | 0.188 | -2 | 0.709 |
DYRK1B |
0.854 | 0.308 | 1 | 0.778 |
GRK5 |
0.854 | -0.060 | -3 | 0.849 |
CAMK2D |
0.854 | 0.063 | -3 | 0.854 |
CDK13 |
0.854 | 0.253 | 1 | 0.763 |
ALK4 |
0.853 | 0.051 | -2 | 0.837 |
NDR1 |
0.853 | 0.068 | -3 | 0.852 |
GRK7 |
0.853 | 0.150 | 1 | 0.734 |
TBK1 |
0.853 | -0.091 | 1 | 0.658 |
AMPKA1 |
0.853 | 0.046 | -3 | 0.870 |
TSSK2 |
0.853 | 0.067 | -5 | 0.870 |
MAPKAPK3 |
0.853 | 0.097 | -3 | 0.805 |
MAPKAPK2 |
0.853 | 0.155 | -3 | 0.768 |
P38D |
0.852 | 0.318 | 1 | 0.701 |
CDK17 |
0.852 | 0.285 | 1 | 0.701 |
GRK6 |
0.852 | 0.020 | 1 | 0.787 |
PKCD |
0.852 | 0.073 | 2 | 0.713 |
CDK3 |
0.852 | 0.286 | 1 | 0.718 |
TSSK1 |
0.852 | 0.095 | -3 | 0.886 |
MARK4 |
0.851 | 0.011 | 4 | 0.800 |
CDK14 |
0.851 | 0.298 | 1 | 0.766 |
P70S6KB |
0.851 | 0.084 | -3 | 0.820 |
PRP4 |
0.851 | 0.232 | -3 | 0.805 |
CAMK2B |
0.851 | 0.115 | 2 | 0.779 |
PKR |
0.851 | 0.024 | 1 | 0.777 |
PKN2 |
0.851 | 0.040 | -3 | 0.852 |
PDHK1 |
0.850 | -0.209 | 1 | 0.779 |
CDK12 |
0.850 | 0.262 | 1 | 0.743 |
RSK4 |
0.849 | 0.177 | -3 | 0.788 |
HUNK |
0.849 | -0.064 | 2 | 0.769 |
TGFBR2 |
0.849 | -0.038 | -2 | 0.796 |
CAMK2A |
0.849 | 0.128 | 2 | 0.785 |
VRK2 |
0.849 | -0.044 | 1 | 0.825 |
RSK3 |
0.849 | 0.110 | -3 | 0.802 |
NEK6 |
0.849 | -0.053 | -2 | 0.851 |
DLK |
0.848 | -0.131 | 1 | 0.767 |
PKACG |
0.848 | 0.103 | -2 | 0.776 |
LATS2 |
0.848 | 0.059 | -5 | 0.749 |
IKKE |
0.848 | -0.114 | 1 | 0.659 |
ALK2 |
0.848 | 0.080 | -2 | 0.822 |
MLK1 |
0.848 | -0.125 | 2 | 0.749 |
PKACB |
0.848 | 0.186 | -2 | 0.722 |
ULK2 |
0.847 | -0.193 | 2 | 0.721 |
ERK2 |
0.847 | 0.226 | 1 | 0.780 |
PASK |
0.847 | 0.160 | -3 | 0.884 |
AMPKA2 |
0.846 | 0.053 | -3 | 0.842 |
MSK1 |
0.846 | 0.150 | -3 | 0.785 |
MLK2 |
0.845 | -0.099 | 2 | 0.760 |
MYLK4 |
0.845 | 0.109 | -2 | 0.811 |
PAK1 |
0.845 | 0.073 | -2 | 0.822 |
MASTL |
0.845 | -0.221 | -2 | 0.809 |
CDK16 |
0.845 | 0.285 | 1 | 0.711 |
RIPK1 |
0.845 | -0.118 | 1 | 0.737 |
IKKA |
0.845 | 0.005 | -2 | 0.735 |
CDK9 |
0.845 | 0.224 | 1 | 0.769 |
CDK10 |
0.844 | 0.289 | 1 | 0.755 |
MOK |
0.844 | 0.312 | 1 | 0.841 |
AURB |
0.844 | 0.121 | -2 | 0.704 |
AKT2 |
0.844 | 0.150 | -3 | 0.736 |
ANKRD3 |
0.843 | -0.194 | 1 | 0.776 |
NEK7 |
0.843 | -0.192 | -3 | 0.842 |
PRKD3 |
0.843 | 0.102 | -3 | 0.779 |
ACVR2B |
0.843 | 0.040 | -2 | 0.790 |
NEK9 |
0.843 | -0.178 | 2 | 0.771 |
MSK2 |
0.843 | 0.088 | -3 | 0.784 |
MEK1 |
0.843 | -0.163 | 2 | 0.794 |
PKCA |
0.843 | 0.060 | 2 | 0.652 |
MNK2 |
0.842 | 0.093 | -2 | 0.823 |
GCN2 |
0.842 | -0.217 | 2 | 0.746 |
MPSK1 |
0.842 | 0.140 | 1 | 0.730 |
ACVR2A |
0.842 | 0.017 | -2 | 0.775 |
SGK3 |
0.842 | 0.117 | -3 | 0.796 |
JNK1 |
0.842 | 0.257 | 1 | 0.742 |
PRKX |
0.842 | 0.207 | -3 | 0.730 |
PIM2 |
0.841 | 0.113 | -3 | 0.781 |
PKCB |
0.841 | 0.042 | 2 | 0.661 |
ATM |
0.841 | -0.032 | 1 | 0.698 |
BMPR1A |
0.841 | 0.113 | 1 | 0.754 |
MLK3 |
0.841 | -0.044 | 2 | 0.667 |
PKG2 |
0.840 | 0.118 | -2 | 0.715 |
PLK1 |
0.840 | -0.092 | -2 | 0.785 |
GAK |
0.839 | 0.095 | 1 | 0.785 |
CDK2 |
0.839 | 0.148 | 1 | 0.815 |
PAK3 |
0.839 | 0.015 | -2 | 0.810 |
IRE1 |
0.839 | -0.065 | 1 | 0.728 |
QSK |
0.839 | 0.035 | 4 | 0.776 |
YSK4 |
0.839 | -0.138 | 1 | 0.703 |
MST3 |
0.839 | 0.034 | 2 | 0.783 |
DCAMKL1 |
0.839 | 0.063 | -3 | 0.817 |
PKCG |
0.839 | 0.026 | 2 | 0.658 |
GRK4 |
0.838 | -0.092 | -2 | 0.835 |
DNAPK |
0.838 | 0.017 | 1 | 0.635 |
NIM1 |
0.838 | -0.061 | 3 | 0.769 |
BCKDK |
0.838 | -0.158 | -1 | 0.746 |
SMMLCK |
0.838 | 0.065 | -3 | 0.835 |
CAMK4 |
0.838 | -0.051 | -3 | 0.834 |
MNK1 |
0.838 | 0.081 | -2 | 0.826 |
WNK3 |
0.837 | -0.265 | 1 | 0.726 |
MELK |
0.837 | -0.006 | -3 | 0.824 |
AURA |
0.837 | 0.106 | -2 | 0.681 |
PKCZ |
0.837 | 0.006 | 2 | 0.707 |
GSK3A |
0.836 | 0.141 | 4 | 0.493 |
FAM20C |
0.836 | 0.096 | 2 | 0.637 |
GRK2 |
0.836 | -0.006 | -2 | 0.739 |
NEK5 |
0.836 | -0.082 | 1 | 0.736 |
TLK2 |
0.836 | -0.074 | 1 | 0.706 |
PAK2 |
0.835 | 0.003 | -2 | 0.804 |
CHK1 |
0.835 | -0.004 | -3 | 0.831 |
DAPK3 |
0.835 | 0.115 | -3 | 0.830 |
SMG1 |
0.834 | -0.068 | 1 | 0.714 |
NEK2 |
0.834 | -0.131 | 2 | 0.745 |
BRAF |
0.834 | -0.132 | -4 | 0.816 |
ULK1 |
0.834 | -0.239 | -3 | 0.808 |
TTBK2 |
0.833 | -0.188 | 2 | 0.635 |
MEK5 |
0.833 | -0.230 | 2 | 0.770 |
PAK6 |
0.833 | 0.101 | -2 | 0.731 |
MEKK2 |
0.833 | -0.114 | 2 | 0.742 |
PKCH |
0.833 | -0.019 | 2 | 0.644 |
TAO3 |
0.833 | -0.026 | 1 | 0.734 |
QIK |
0.833 | -0.089 | -3 | 0.849 |
MEKK3 |
0.832 | -0.132 | 1 | 0.739 |
NUAK1 |
0.832 | -0.012 | -3 | 0.812 |
MARK3 |
0.832 | 0.005 | 4 | 0.722 |
DRAK1 |
0.832 | -0.032 | 1 | 0.710 |
WNK4 |
0.831 | -0.079 | -2 | 0.883 |
MLK4 |
0.831 | -0.113 | 2 | 0.649 |
LKB1 |
0.831 | -0.004 | -3 | 0.845 |
PKACA |
0.831 | 0.144 | -2 | 0.671 |
CHAK1 |
0.831 | -0.156 | 2 | 0.713 |
CAMK1G |
0.831 | 0.033 | -3 | 0.791 |
CDK4 |
0.830 | 0.240 | 1 | 0.736 |
SIK |
0.830 | 0.010 | -3 | 0.790 |
AKT1 |
0.830 | 0.121 | -3 | 0.752 |
IRE2 |
0.830 | -0.111 | 2 | 0.675 |
GSK3B |
0.830 | 0.057 | 4 | 0.486 |
CDK6 |
0.830 | 0.225 | 1 | 0.743 |
GCK |
0.829 | 0.020 | 1 | 0.730 |
DAPK1 |
0.829 | 0.111 | -3 | 0.818 |
PHKG1 |
0.829 | -0.055 | -3 | 0.846 |
PERK |
0.829 | -0.170 | -2 | 0.816 |
PLK3 |
0.829 | -0.121 | 2 | 0.748 |
CK1E |
0.829 | 0.073 | -3 | 0.593 |
MEKK1 |
0.828 | -0.203 | 1 | 0.730 |
ERK7 |
0.828 | 0.068 | 2 | 0.482 |
BRSK1 |
0.828 | -0.003 | -3 | 0.820 |
MARK2 |
0.828 | -0.046 | 4 | 0.686 |
ZAK |
0.827 | -0.189 | 1 | 0.714 |
PINK1 |
0.826 | -0.135 | 1 | 0.803 |
PDK1 |
0.826 | -0.065 | 1 | 0.715 |
CAMK1D |
0.826 | 0.072 | -3 | 0.725 |
ROCK2 |
0.826 | 0.132 | -3 | 0.816 |
TNIK |
0.826 | 0.008 | 3 | 0.835 |
IRAK4 |
0.825 | -0.117 | 1 | 0.719 |
SSTK |
0.825 | -0.007 | 4 | 0.775 |
CK1D |
0.825 | 0.073 | -3 | 0.544 |
BUB1 |
0.825 | 0.153 | -5 | 0.821 |
DCAMKL2 |
0.825 | -0.033 | -3 | 0.829 |
CAMKK2 |
0.825 | -0.123 | -2 | 0.743 |
NEK11 |
0.825 | -0.163 | 1 | 0.719 |
EEF2K |
0.824 | -0.044 | 3 | 0.798 |
MAPKAPK5 |
0.824 | -0.046 | -3 | 0.757 |
TAO2 |
0.824 | -0.124 | 2 | 0.781 |
HPK1 |
0.824 | 0.002 | 1 | 0.725 |
TLK1 |
0.824 | -0.156 | -2 | 0.837 |
MARK1 |
0.823 | -0.062 | 4 | 0.746 |
HRI |
0.823 | -0.262 | -2 | 0.831 |
SGK1 |
0.823 | 0.136 | -3 | 0.663 |
BRSK2 |
0.823 | -0.074 | -3 | 0.830 |
CAMKK1 |
0.823 | -0.188 | -2 | 0.742 |
DMPK1 |
0.823 | 0.154 | -3 | 0.787 |
CK2A2 |
0.822 | 0.115 | 1 | 0.714 |
MAP3K15 |
0.822 | -0.089 | 1 | 0.694 |
LRRK2 |
0.822 | -0.116 | 2 | 0.786 |
VRK1 |
0.822 | -0.082 | 2 | 0.783 |
PKCE |
0.822 | 0.059 | 2 | 0.643 |
KHS1 |
0.822 | 0.026 | 1 | 0.712 |
GRK3 |
0.822 | 0.007 | -2 | 0.705 |
NEK8 |
0.822 | -0.202 | 2 | 0.753 |
PKCT |
0.821 | -0.012 | 2 | 0.652 |
MEKK6 |
0.821 | -0.101 | 1 | 0.720 |
HGK |
0.821 | -0.071 | 3 | 0.831 |
MRCKB |
0.821 | 0.105 | -3 | 0.768 |
NEK4 |
0.821 | -0.147 | 1 | 0.708 |
KHS2 |
0.820 | 0.046 | 1 | 0.725 |
NEK1 |
0.820 | -0.096 | 1 | 0.715 |
P70S6K |
0.820 | 0.028 | -3 | 0.740 |
MINK |
0.820 | -0.082 | 1 | 0.713 |
PLK4 |
0.820 | -0.154 | 2 | 0.575 |
MST2 |
0.819 | -0.132 | 1 | 0.736 |
CK1A2 |
0.819 | 0.049 | -3 | 0.546 |
PKCI |
0.819 | -0.012 | 2 | 0.667 |
MRCKA |
0.819 | 0.082 | -3 | 0.779 |
CHK2 |
0.819 | 0.074 | -3 | 0.682 |
SNRK |
0.818 | -0.184 | 2 | 0.635 |
TAK1 |
0.818 | -0.131 | 1 | 0.719 |
AKT3 |
0.818 | 0.133 | -3 | 0.683 |
SBK |
0.818 | 0.136 | -3 | 0.623 |
PBK |
0.817 | 0.007 | 1 | 0.705 |
CK2A1 |
0.814 | 0.105 | 1 | 0.698 |
HASPIN |
0.813 | 0.053 | -1 | 0.709 |
LOK |
0.813 | -0.096 | -2 | 0.756 |
PDHK3_TYR |
0.813 | 0.306 | 4 | 0.898 |
PAK5 |
0.813 | 0.043 | -2 | 0.680 |
CAMK1A |
0.812 | 0.068 | -3 | 0.696 |
MST1 |
0.811 | -0.174 | 1 | 0.719 |
ROCK1 |
0.810 | 0.090 | -3 | 0.780 |
YSK1 |
0.809 | -0.124 | 2 | 0.742 |
PHKG2 |
0.809 | -0.079 | -3 | 0.812 |
CRIK |
0.809 | 0.104 | -3 | 0.750 |
PLK2 |
0.808 | -0.062 | -3 | 0.758 |
PAK4 |
0.808 | 0.052 | -2 | 0.690 |
SLK |
0.807 | -0.116 | -2 | 0.704 |
PKN1 |
0.807 | -0.000 | -3 | 0.758 |
BIKE |
0.807 | 0.006 | 1 | 0.676 |
IRAK1 |
0.807 | -0.334 | -1 | 0.716 |
CK1G1 |
0.807 | -0.005 | -3 | 0.577 |
TTK |
0.806 | -0.083 | -2 | 0.817 |
OSR1 |
0.805 | -0.092 | 2 | 0.741 |
MEK2 |
0.805 | -0.310 | 2 | 0.755 |
PDHK4_TYR |
0.805 | 0.171 | 2 | 0.858 |
TTBK1 |
0.805 | -0.231 | 2 | 0.557 |
MYO3B |
0.804 | -0.052 | 2 | 0.755 |
MAP2K4_TYR |
0.803 | 0.099 | -1 | 0.858 |
TESK1_TYR |
0.802 | 0.046 | 3 | 0.857 |
ASK1 |
0.802 | -0.157 | 1 | 0.687 |
MAP2K6_TYR |
0.802 | 0.109 | -1 | 0.855 |
STK33 |
0.801 | -0.178 | 2 | 0.560 |
PKMYT1_TYR |
0.800 | 0.044 | 3 | 0.832 |
BMPR2_TYR |
0.800 | 0.087 | -1 | 0.858 |
ALPHAK3 |
0.799 | -0.075 | -1 | 0.766 |
LIMK2_TYR |
0.799 | 0.094 | -3 | 0.881 |
PDHK1_TYR |
0.798 | 0.048 | -1 | 0.866 |
NEK3 |
0.798 | -0.193 | 1 | 0.676 |
AAK1 |
0.797 | 0.066 | 1 | 0.589 |
MAP2K7_TYR |
0.796 | -0.112 | 2 | 0.819 |
RIPK2 |
0.795 | -0.323 | 1 | 0.663 |
MYO3A |
0.795 | -0.136 | 1 | 0.719 |
PKG1 |
0.793 | 0.041 | -2 | 0.629 |
EPHA6 |
0.793 | 0.047 | -1 | 0.838 |
TAO1 |
0.791 | -0.155 | 1 | 0.653 |
TXK |
0.791 | 0.128 | 1 | 0.790 |
PINK1_TYR |
0.791 | -0.186 | 1 | 0.783 |
EPHB4 |
0.790 | 0.020 | -1 | 0.808 |
RET |
0.789 | -0.088 | 1 | 0.738 |
ABL2 |
0.789 | 0.044 | -1 | 0.793 |
YANK3 |
0.789 | -0.078 | 2 | 0.372 |
YES1 |
0.786 | -0.017 | -1 | 0.839 |
LIMK1_TYR |
0.785 | -0.171 | 2 | 0.794 |
FGR |
0.785 | -0.026 | 1 | 0.779 |
MST1R |
0.785 | -0.123 | 3 | 0.785 |
ABL1 |
0.784 | 0.011 | -1 | 0.786 |
TYRO3 |
0.784 | -0.132 | 3 | 0.777 |
ROS1 |
0.783 | -0.118 | 3 | 0.749 |
CSF1R |
0.783 | -0.082 | 3 | 0.774 |
LCK |
0.783 | 0.050 | -1 | 0.823 |
TNK2 |
0.783 | -0.004 | 3 | 0.739 |
STLK3 |
0.782 | -0.267 | 1 | 0.679 |
EPHA4 |
0.782 | -0.018 | 2 | 0.760 |
BLK |
0.782 | 0.073 | -1 | 0.826 |
JAK2 |
0.782 | -0.150 | 1 | 0.727 |
TYK2 |
0.781 | -0.220 | 1 | 0.727 |
SRMS |
0.781 | -0.018 | 1 | 0.791 |
DDR1 |
0.780 | -0.156 | 4 | 0.813 |
HCK |
0.780 | -0.038 | -1 | 0.815 |
JAK3 |
0.779 | -0.115 | 1 | 0.715 |
FER |
0.779 | -0.121 | 1 | 0.800 |
FYN |
0.778 | 0.071 | -1 | 0.812 |
ITK |
0.778 | -0.025 | -1 | 0.772 |
EPHB1 |
0.778 | -0.064 | 1 | 0.786 |
EPHB3 |
0.777 | -0.054 | -1 | 0.787 |
BMX |
0.777 | 0.000 | -1 | 0.722 |
CK1A |
0.776 | 0.019 | -3 | 0.456 |
INSRR |
0.776 | -0.120 | 3 | 0.718 |
KIT |
0.776 | -0.104 | 3 | 0.772 |
TNK1 |
0.776 | -0.066 | 3 | 0.766 |
EPHB2 |
0.776 | -0.044 | -1 | 0.787 |
KDR |
0.775 | -0.092 | 3 | 0.729 |
MERTK |
0.775 | -0.060 | 3 | 0.753 |
TNNI3K_TYR |
0.774 | -0.042 | 1 | 0.759 |
FGFR2 |
0.774 | -0.141 | 3 | 0.757 |
MET |
0.774 | -0.068 | 3 | 0.760 |
JAK1 |
0.773 | -0.084 | 1 | 0.671 |
TEK |
0.772 | -0.146 | 3 | 0.712 |
TEC |
0.771 | -0.078 | -1 | 0.721 |
AXL |
0.770 | -0.145 | 3 | 0.749 |
NEK10_TYR |
0.770 | -0.145 | 1 | 0.603 |
EPHA7 |
0.770 | -0.059 | 2 | 0.746 |
WEE1_TYR |
0.769 | -0.087 | -1 | 0.732 |
FLT3 |
0.769 | -0.210 | 3 | 0.773 |
DDR2 |
0.768 | -0.009 | 3 | 0.697 |
PTK2B |
0.767 | -0.028 | -1 | 0.762 |
FGFR1 |
0.767 | -0.196 | 3 | 0.735 |
PDGFRB |
0.767 | -0.261 | 3 | 0.778 |
EPHA3 |
0.766 | -0.129 | 2 | 0.724 |
PTK2 |
0.766 | 0.059 | -1 | 0.778 |
FLT1 |
0.765 | -0.114 | -1 | 0.798 |
LYN |
0.765 | -0.072 | 3 | 0.704 |
FRK |
0.765 | -0.098 | -1 | 0.814 |
EPHA1 |
0.765 | -0.119 | 3 | 0.733 |
LTK |
0.764 | -0.164 | 3 | 0.711 |
BTK |
0.764 | -0.220 | -1 | 0.734 |
SRC |
0.764 | -0.041 | -1 | 0.807 |
ERBB2 |
0.764 | -0.169 | 1 | 0.706 |
FGFR3 |
0.763 | -0.151 | 3 | 0.728 |
ALK |
0.763 | -0.193 | 3 | 0.690 |
EPHA5 |
0.762 | -0.070 | 2 | 0.746 |
SYK |
0.761 | 0.049 | -1 | 0.764 |
NTRK1 |
0.761 | -0.242 | -1 | 0.785 |
MATK |
0.761 | -0.118 | -1 | 0.729 |
CK1G3 |
0.761 | -0.023 | -3 | 0.413 |
EPHA8 |
0.760 | -0.075 | -1 | 0.778 |
PDGFRA |
0.760 | -0.316 | 3 | 0.781 |
PTK6 |
0.760 | -0.259 | -1 | 0.705 |
INSR |
0.758 | -0.208 | 3 | 0.701 |
EGFR |
0.758 | -0.093 | 1 | 0.625 |
NTRK3 |
0.758 | -0.162 | -1 | 0.744 |
FLT4 |
0.756 | -0.235 | 3 | 0.726 |
CSK |
0.756 | -0.156 | 2 | 0.747 |
YANK2 |
0.756 | -0.120 | 2 | 0.384 |
NTRK2 |
0.754 | -0.294 | 3 | 0.730 |
FGFR4 |
0.754 | -0.117 | -1 | 0.753 |
EPHA2 |
0.751 | -0.076 | -1 | 0.747 |
ERBB4 |
0.750 | -0.047 | 1 | 0.658 |
IGF1R |
0.745 | -0.176 | 3 | 0.641 |
ZAP70 |
0.744 | 0.017 | -1 | 0.702 |
CK1G2 |
0.742 | -0.027 | -3 | 0.501 |
MUSK |
0.740 | -0.210 | 1 | 0.613 |
FES |
0.735 | -0.155 | -1 | 0.699 |