Motif 118 (n=122)

Position-wise Probabilities

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uniprot genes site source protein function
A2A3K4 PTPDC1 S472 ochoa Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) May play roles in cilia formation and/or maintenance. {ECO:0000250}.
A6H8Y1 BDP1 S1403 ochoa Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}.
O00444 PLK4 S421 ochoa Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}.
O15042 U2SURP S818 ochoa U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) None
O43149 ZZEF1 S240 ochoa Zinc finger ZZ-type and EF-hand domain-containing protein 1 Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}.
O75044 SRGAP2 S424 ochoa SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.
O75128 COBL S741 ochoa Protein cordon-bleu Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}.
O75167 PHACTR2 S237 ochoa Phosphatase and actin regulator 2 None
O94929 ABLIM3 S163 ochoa Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.
O95235 KIF20A S254 ochoa Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
O95359 TACC2 S2366 ochoa Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}.
O95402 MED26 S447 ochoa Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
O95466 FMNL1 S950 ochoa Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.
O95677 EYA4 S37 ochoa Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4) Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}.
P0DJJ0 SRGAP2C S424 ochoa SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1) Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212, ECO:0000269|PubMed:31822692, ECO:0000269|PubMed:34707291}.
P0DMB2 C8orf88 S70 ochoa Uncharacterized protein C8orf88 None
P0DMP2 SRGAP2B S423 ochoa SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2) May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692). In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692). {ECO:0000269|PubMed:31822692, ECO:0000305|PubMed:22559944, ECO:0000305|PubMed:31822692}.
P10827 THRA S21 ochoa Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) [Isoform Alpha-1]: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:19926848}.; FUNCTION: [Isoform Alpha-2]: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. {ECO:0000269|PubMed:8910441}.
P17948 FLT1 S1003 ochoa Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}.
P19447 ERCC3 S231 ochoa General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}.
P19634 SLC9A1 S605 ochoa Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}.
P24278 ZBTB25 S342 ochoa Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP) May be involved in transcriptional regulation.
P25054 APC S2621 ochoa Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
P29374 ARID4A S1145 ochoa|psp AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}.
P35251 RFC1 Y106 ochoa Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}.
P35251 RFC1 S518 psp Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}.
P38398 BRCA1 S1191 ochoa|psp Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
P42574 CASP3 S24 ochoa Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9334240}.
P46013 MKI67 S3082 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46100 ATRX S316 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P62879 GNB2 S136 ochoa Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
P78344 EIF4G2 S443 ochoa Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.
P80192 MAP3K9 S693 ochoa Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}.
Q03468 ERCC6 S1146 ochoa DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}.
Q04727 TLE4 S208 ochoa Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}.
Q06187 BTK S323 ochoa Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}.
Q12830 BPTF S737 ochoa Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}.
Q12888 TP53BP1 S1288 ochoa TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13009 TIAM1 S298 ochoa Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}.
Q14191 WRN S1399 ochoa Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}.
Q14938 NFIX S288 ochoa Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Q14966 ZNF638 S585 ochoa Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}.
Q149N8 SHPRH S93 ochoa E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase) E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:18719106}.
Q15047 SETDB1 S1066 ochoa|psp Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}.
Q16181 SEPTIN7 S77 ochoa Septin-7 (CDC10 protein homolog) Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18460473, ECO:0000305|PubMed:25588830}.
Q16236 NFE2L2 S215 ochoa|psp Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}.
Q3KR37 GRAMD1B S274 ochoa Protein Aster-B (GRAM domain-containing protein 1B) Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}.
Q3L8U1 CHD9 S2079 ochoa Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
Q4G0N4 NADK2 S376 psp NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial) Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}.
Q5CZC0 FSIP2 S3898 ochoa Fibrous sheath-interacting protein 2 Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}.
Q5JWR5 DOP1A S1023 ochoa Protein DOP1A May be involved in protein traffic between late Golgi and early endosomes. {ECO:0000250|UniProtKB:Q03921}.
Q5T7B8 KIF24 S646 ochoa Kinesin-like protein KIF24 Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}.
Q5UIP0 RIF1 S1772 ochoa Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}.
Q63HK5 TSHZ3 S515 ochoa Teashirt homolog 3 (Zinc finger protein 537) Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}.
Q68CP4 HGSNAT S243 ochoa Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:19823584, ECO:0000269|PubMed:20650889}.
Q68E01 INTS3 S995 ochoa Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS3 is involved in the post-termination step: INTS3 binds INTS7 in the open conformation of integrator complex and prevents the rebinding of Pol II to the integrator after termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
Q6KC79 NIPBL S850 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6RI45 BRWD3 S1386 ochoa Bromodomain and WD repeat-containing protein 3 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}.
Q6UB99 ANKRD11 S276 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6ZSB9 ZBTB49 S178 ochoa Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 1]: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive). {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter. {ECO:0000269|PubMed:25245946}.
Q6ZSB9 ZBTB49 S592 ochoa Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 1]: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive). {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter. {ECO:0000269|PubMed:25245946}.
Q7Z401 DENND4A S963 ochoa C-myc promoter-binding protein (DENN domain-containing protein 4A) Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}.
Q7Z6B7 SRGAP1 S413 ochoa SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
Q86SQ0 PHLDB2 S294 ochoa Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Q86UR5 RIMS1 S999 ochoa Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}.
Q86W56 PARG S323 ochoa Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}.
Q86XP3 DDX42 S831 ochoa ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}.
Q8IX21 SLF2 S340 ochoa SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}.
Q8IYD8 FANCM S1045 psp Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}.
Q8IYH5 ZZZ3 S426 ochoa ZZ-type zinc finger-containing protein 3 Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}.
Q8N4S0 CCDC82 S88 ochoa Coiled-coil domain-containing protein 82 None
Q8NDI1 EHBP1 S578 ochoa EH domain-binding protein 1 May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}.
Q92574 TSC1 S270 ochoa Hamartin (Tuberous sclerosis 1 protein) Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}.
Q96BK5 PINX1 S117 psp PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}.
Q96CM8 ACSF2 S52 ochoa Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2) Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219). {ECO:0000269|PubMed:16380219, ECO:0000269|PubMed:17762044}.
Q96DU3 SLAMF6 S291 ochoa SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352) Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:16920955, PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q9ET39, ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:16920955, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.
Q96IZ7 RSRC1 S239 ochoa Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}.
Q96JM3 CHAMP1 S675 ochoa Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
Q96M89 CCDC138 S49 ochoa Coiled-coil domain-containing protein 138 None
Q96NJ6 ZFP3 S63 ochoa Zinc finger protein 3 homolog (Zfp-3) (Zinc finger protein 752) May be involved in transcriptional regulation.
Q96PZ2 FAM111A S26 ochoa Serine protease FAM111A (EC 3.4.21.-) Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:32165630). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:32165630). Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors (PubMed:32165630). Required for PCNA loading on replication sites (PubMed:24561620). Promotes S-phase entry and DNA synthesis (PubMed:24561620). Also acts as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus (PubMed:23093934, PubMed:37607234). Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity (PubMed:33369867, PubMed:37607234). In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy (PubMed:37607234). {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:32165630, ECO:0000269|PubMed:37607234}.
Q96RS0 TGS1 S154 ochoa Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}.
Q96T37 RBM15 S182 ochoa RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}.
Q96T58 SPEN S1062 ochoa Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
Q99675 CGRRF1 S252 ochoa Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) (RING finger protein 197) Able to inhibit growth in several cell lines. {ECO:0000250|UniProtKB:P97587}.
Q99808 SLC29A1 S271 ochoa Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}.
Q9BY42 RTF2 S235 ochoa Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}.
Q9H0G5 NSRP1 S291 ochoa Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}.
Q9H2P0 ADNP S970 ochoa Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}.
Q9H2Y7 ZNF106 S753 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H6S1 AZI2 S318 ochoa 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}.
Q9H706 GAREM1 S759 ochoa GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}.
Q9H9A7 RMI1 S292 ochoa|psp RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}.
Q9HAV0 GNB4 S136 ochoa Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4) Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Q9HCJ3 RAVER2 S635 ochoa Ribonucleoprotein PTB-binding 2 (Protein raver-2) May bind single-stranded nucleic acids. {ECO:0000305}.
Q9HCM1 RESF1 S868 ochoa Retroelement silencing factor 1 Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}.
Q9NWH9 SLTM S374 ochoa SAFB-like transcription modulator (Modulator of estrogen-induced transcription) When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9NXL9 MCM9 S942 ochoa DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}.
Q9NXP7 GIN1 S494 ochoa Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain-containing protein) None
Q9NY27 PPP4R2 S388 ochoa Serine/threonine-protein phosphatase 4 regulatory subunit 2 Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}.
Q9NYP3 DONSON S139 ochoa Protein downstream neighbor of Son (B17) Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}.
Q9NZN8 CNOT2 S61 ochoa CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.
Q9P0V9 SEPTIN10 S434 ochoa Septin-10 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}.
Q9P243 ZFAT S21 ochoa Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}.
Q9P2R6 RERE S679 ochoa Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}.
Q9UEG4 ZNF629 S52 ochoa Zinc finger protein 629 (Zinc finger protein 65) May be involved in transcriptional regulation.
Q9UHB6 LIMA1 S168 ochoa LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
Q9UHB7 AFF4 S409 ochoa AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Q9UJF2 RASAL2 S1119 ochoa Ras GTPase-activating protein nGAP (RAS protein activator-like 2) Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UKJ3 GPATCH8 S491 ochoa G patch domain-containing protein 8 None
Q9UKJ3 GPATCH8 S653 ochoa G patch domain-containing protein 8 None
Q9UKK3 PARP4 S1306 ochoa Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.
Q9ULI3 HEG1 S426 ochoa Protein HEG homolog 1 Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}.
Q9ULJ3 ZBTB21 S714 ochoa Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}.
Q9UNQ0 ABCG2 S353 ochoa Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response. {ECO:0000250|UniProtKB:Q7TMS5, ECO:0000269|PubMed:11306452, ECO:0000269|PubMed:12477054, ECO:0000269|PubMed:12682043, ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:15670731, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:19506252, ECO:0000269|PubMed:20110355, ECO:0000269|PubMed:20368174, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181, ECO:0000269|PubMed:28554189, ECO:0000269|PubMed:30405239, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042, ECO:0000269|PubMed:38181789, ECO:0000305|PubMed:12958161}.
Q9Y2D8 SSX2IP S587 ochoa Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}.
Q9Y2J2 EPB41L3 S495 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
Q9Y6A5 TACC3 S25 ochoa Transforming acidic coiled-coil-containing protein 3 (ERIC-1) Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
Q9UL25 RAB21 S143 Sugiyama Ras-related protein Rab-21 (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18804435, PubMed:25648148, PubMed:31455601). RAB21 is involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601). {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:31455601}.
Q13114 TRAF3 S75 PSP TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768). Also acts as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819, ECO:0000269|PubMed:25847972, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:32562145, ECO:0000269|PubMed:33148796, ECO:0000269|PubMed:33608556, ECO:0000269|PubMed:34011520}.
Q27J81 INF2 S855 Sugiyama Inverted formin-2 (HBEBP2-binding protein C) Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}.
O00562 PITPNM1 S326 Sugiyama Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}.
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reactome_id name p -log10_p
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.000135 3.870
R-HSA-428543 Inactivation of CDC42 and RAC1 0.000135 3.870
R-HSA-5693532 DNA Double-Strand Break Repair 0.000079 4.103
R-HSA-73894 DNA Repair 0.000061 4.217
R-HSA-8964315 G beta:gamma signalling through BTK 0.000514 3.289
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.001006 2.998
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.001130 2.947
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.001130 2.947
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.001130 2.947
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.001130 2.947
R-HSA-5693607 Processing of DNA double-strand break ends 0.000805 3.094
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.000575 3.240
R-HSA-5693538 Homology Directed Repair 0.000731 3.136
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.002081 2.682
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.002460 2.609
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.002926 2.534
R-HSA-397795 G-protein beta:gamma signalling 0.003956 2.403
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.004543 2.343
R-HSA-5693537 Resolution of D-Loop Structures 0.004243 2.372
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.003956 2.403
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.003956 2.403
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.003264 2.486
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.004543 2.343
R-HSA-69473 G2/M DNA damage checkpoint 0.004469 2.350
R-HSA-9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... 0.003637 2.439
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.004855 2.314
R-HSA-416482 G alpha (12/13) signalling events 0.005277 2.278
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.005277 2.278
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.005869 2.231
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.006623 2.179
R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 0.007979 2.098
R-HSA-9711123 Cellular response to chemical stress 0.008828 2.054
R-HSA-9675135 Diseases of DNA repair 0.009629 2.016
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.011131 1.953
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.010617 1.974
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.015895 1.799
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.015895 1.799
R-HSA-9673013 Diseases of Telomere Maintenance 0.015895 1.799
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.015895 1.799
R-HSA-9699150 Defective DNA double strand break response due to BARD1 loss of function 0.015895 1.799
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.015895 1.799
R-HSA-9663199 Defective DNA double strand break response due to BRCA1 loss of function 0.015895 1.799
R-HSA-418217 G beta:gamma signalling through PLC beta 0.014937 1.826
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.015136 1.820
R-HSA-6782135 Dual incision in TC-NER 0.016411 1.785
R-HSA-8964616 G beta:gamma signalling through CDC42 0.012582 1.900
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.012008 1.921
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 0.016180 1.791
R-HSA-500657 Presynaptic function of Kainate receptors 0.014937 1.826
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.017070 1.768
R-HSA-202040 G-protein activation 0.018794 1.726
R-HSA-392170 ADP signalling through P2Y purinoceptor 12 0.018794 1.726
R-HSA-9707616 Heme signaling 0.019136 1.718
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.023021 1.638
R-HSA-5693606 DNA Double Strand Break Response 0.022873 1.641
R-HSA-5602571 TRAF3 deficiency - HSE 0.023748 1.624
R-HSA-429947 Deadenylation of mRNA 0.024509 1.611
R-HSA-1296041 Activation of G protein gated Potassium channels 0.026036 1.584
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.026036 1.584
R-HSA-1296059 G protein gated Potassium channels 0.026036 1.584
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.023820 1.623
R-HSA-428930 Thromboxane signalling through TP receptor 0.024509 1.611
R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.024509 1.611
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.029619 1.528
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.027600 1.559
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.027600 1.559
R-HSA-9843745 Adipogenesis 0.031159 1.506
R-HSA-451326 Activation of kainate receptors upon glutamate binding 0.030839 1.511
R-HSA-69481 G2/M Checkpoints 0.027957 1.554
R-HSA-2206291 MPS IIIC - Sanfilippo syndrome C 0.031540 1.501
R-HSA-194306 Neurophilin interactions with VEGF and VEGFR 0.031540 1.501
R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.031540 1.501
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.037738 1.423
R-HSA-1296065 Inwardly rectifying K+ channels 0.037738 1.423
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.034220 1.466
R-HSA-420092 Glucagon-type ligand receptors 0.032512 1.488
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.034220 1.466
R-HSA-9707564 Cytoprotection by HMOX1 0.037302 1.428
R-HSA-9008059 Interleukin-37 signaling 0.034220 1.466
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.046937 1.328
R-HSA-5696400 Dual Incision in GG-NER 0.043261 1.364
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.043261 1.364
R-HSA-392518 Signal amplification 0.043261 1.364
R-HSA-165181 Inhibition of TSC complex formation by PKB 0.046937 1.328
R-HSA-9960525 CASP5-mediated substrate cleavage 0.039269 1.406
R-HSA-205025 NADE modulates death signalling 0.046937 1.328
R-HSA-9960519 CASP4-mediated substrate cleavage 0.039269 1.406
R-HSA-9707587 Regulation of HMOX1 expression and activity 0.046937 1.328
R-HSA-163359 Glucagon signaling in metabolic regulation 0.041388 1.383
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.043261 1.364
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.041489 1.382
R-HSA-3700989 Transcriptional Regulation by TP53 0.042441 1.372
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.047100 1.327
R-HSA-74158 RNA Polymerase III Transcription 0.047100 1.327
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.049064 1.309
R-HSA-5689896 Ovarian tumor domain proteases 0.049064 1.309
R-HSA-9818025 NFE2L2 regulating TCA cycle genes 0.054545 1.263
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.054545 1.263
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.057210 1.243
R-HSA-991365 Activation of GABAB receptors 0.061448 1.211
R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 0.054545 1.263
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.061448 1.211
R-HSA-977444 GABA B receptor activation 0.061448 1.211
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.061448 1.211
R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.055132 1.259
R-HSA-5260271 Diseases of Immune System 0.055132 1.259
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.059316 1.227
R-HSA-157579 Telomere Maintenance 0.056644 1.247
R-HSA-111463 SMAC (DIABLO) binds to IAPs 0.054545 1.263
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.057210 1.243
R-HSA-165159 MTOR signalling 0.061448 1.211
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.053081 1.275
R-HSA-8953750 Transcriptional Regulation by E2F6 0.053081 1.275
R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 0.062092 1.207
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization 0.062092 1.207
R-HSA-111469 SMAC, XIAP-regulated apoptotic response 0.062092 1.207
R-HSA-194313 VEGF ligand-receptor interactions 0.062092 1.207
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.084377 1.074
R-HSA-9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 0.084377 1.074
R-HSA-4839744 Signaling by APC mutants 0.106136 0.974
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.106136 0.974
R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.106136 0.974
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.106136 0.974
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.113275 0.946
R-HSA-9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 0.113275 0.946
R-HSA-5339716 Signaling by GSK3beta mutants 0.113275 0.946
R-HSA-4839743 Signaling by CTNNB1 phospho-site mutants 0.120357 0.920
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 0.120357 0.920
R-HSA-5358747 CTNNB1 S33 mutants aren't phosphorylated 0.120357 0.920
R-HSA-5358752 CTNNB1 T41 mutants aren't phosphorylated 0.120357 0.920
R-HSA-5358751 CTNNB1 S45 mutants aren't phosphorylated 0.120357 0.920
R-HSA-5358749 CTNNB1 S37 mutants aren't phosphorylated 0.120357 0.920
R-HSA-196299 Beta-catenin phosphorylation cascade 0.141267 0.850
R-HSA-5656121 Translesion synthesis by POLI 0.148127 0.829
R-HSA-5655862 Translesion synthesis by POLK 0.154933 0.810
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.168383 0.774
R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.188160 0.725
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.070230 1.153
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.194649 0.711
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.194649 0.711
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.207471 0.683
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.207471 0.683
R-HSA-112382 Formation of RNA Pol II elongation complex 0.084106 1.075
R-HSA-1989781 PPARA activates gene expression 0.162301 0.790
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.127382 0.895
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.166169 0.779
R-HSA-72163 mRNA Splicing - Major Pathway 0.243925 0.613
R-HSA-5656169 Termination of translesion DNA synthesis 0.244736 0.611
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.188493 0.725
R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 0.113275 0.946
R-HSA-936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 0.154933 0.810
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.213806 0.670
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.129845 0.887
R-HSA-72086 mRNA Capping 0.244736 0.611
R-HSA-5696398 Nucleotide Excision Repair 0.068465 1.165
R-HSA-110312 Translesion synthesis by REV1 0.141267 0.850
R-HSA-69091 Polymerase switching 0.120357 0.920
R-HSA-69109 Leading Strand Synthesis 0.120357 0.920
R-HSA-110320 Translesion Synthesis by POLH 0.175028 0.757
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.194649 0.711
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.201085 0.697
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.086495 1.063
R-HSA-73863 RNA Polymerase I Transcription Termination 0.232512 0.634
R-HSA-4641265 Repression of WNT target genes 0.120357 0.920
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.091688 1.038
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.250775 0.601
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.168498 0.773
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.201085 0.697
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.140669 0.852
R-HSA-4791275 Signaling by WNT in cancer 0.262711 0.581
R-HSA-918233 TRAF3-dependent IRF activation pathway 0.154933 0.810
R-HSA-75153 Apoptotic execution phase 0.070230 1.153
R-HSA-9032845 Activated NTRK2 signals through CDK5 0.077008 1.113
R-HSA-2470946 Cohesin Loading onto Chromatin 0.077008 1.113
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand 0.091688 1.038
R-HSA-4839748 Signaling by AMER1 mutants 0.113275 0.946
R-HSA-4839735 Signaling by AXIN mutants 0.113275 0.946
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.168383 0.774
R-HSA-73980 RNA Polymerase III Transcription Termination 0.168383 0.774
R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.220091 0.657
R-HSA-73864 RNA Polymerase I Transcription 0.151680 0.819
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 0.127382 0.895
R-HSA-9634597 GPER1 signaling 0.074765 1.126
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.201085 0.697
R-HSA-429914 Deadenylation-dependent mRNA decay 0.101237 0.995
R-HSA-9675126 Diseases of mitotic cell cycle 0.262711 0.581
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.146153 0.835
R-HSA-390466 Chaperonin-mediated protein folding 0.179880 0.745
R-HSA-2424491 DAP12 signaling 0.250775 0.601
R-HSA-2161517 Abacavir transmembrane transport 0.069579 1.158
R-HSA-1483226 Synthesis of PI 0.106136 0.974
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.188160 0.725
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.213806 0.670
R-HSA-113418 Formation of the Early Elongation Complex 0.238648 0.622
R-HSA-418597 G alpha (z) signalling events 0.091332 1.039
R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.232512 0.634
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.232512 0.634
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.250775 0.601
R-HSA-69186 Lagging Strand Synthesis 0.188160 0.725
R-HSA-425986 Sodium/Proton exchangers 0.084377 1.074
R-HSA-140342 Apoptosis induced DNA fragmentation 0.098941 1.005
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.161685 0.791
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production 0.067997 1.168
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.226326 0.645
R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma ... 0.232512 0.634
R-HSA-977443 GABA receptor activation 0.103758 0.984
R-HSA-391251 Protein folding 0.197161 0.705
R-HSA-73886 Chromosome Maintenance 0.095112 1.022
R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.226326 0.645
R-HSA-422356 Regulation of insulin secretion 0.217565 0.662
R-HSA-5620971 Pyroptosis 0.238648 0.622
R-HSA-195721 Signaling by WNT 0.251632 0.599
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 0.113275 0.946
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.067997 1.168
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.238648 0.622
R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.250775 0.601
R-HSA-69190 DNA strand elongation 0.262711 0.581
R-HSA-4086398 Ca2+ pathway 0.137945 0.860
R-HSA-180786 Extension of Telomeres 0.101237 0.995
R-HSA-9755088 Ribavirin ADME 0.194649 0.711
R-HSA-2160916 Hyaluronan degradation 0.220091 0.657
R-HSA-5689901 Metalloprotease DUBs 0.226326 0.645
R-HSA-1266695 Interleukin-7 signaling 0.220091 0.657
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.256767 0.590
R-HSA-1296071 Potassium Channels 0.211714 0.674
R-HSA-111471 Apoptotic factor-mediated response 0.168383 0.774
R-HSA-8863795 Downregulation of ERBB2 signaling 0.250775 0.601
R-HSA-166208 mTORC1-mediated signalling 0.201085 0.697
R-HSA-2024096 HS-GAG degradation 0.262711 0.581
R-HSA-445717 Aquaporin-mediated transport 0.106296 0.973
R-HSA-9793528 Ciprofloxacin ADME 0.134352 0.872
R-HSA-9686114 Non-canonical inflammasome activation 0.134352 0.872
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.137945 0.860
R-HSA-9683610 Maturation of nucleoprotein 0.127382 0.895
R-HSA-2161522 Abacavir ADME 0.226326 0.645
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 0.157248 0.803
R-HSA-418346 Platelet homeostasis 0.244049 0.613
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.174173 0.759
R-HSA-2206281 Mucopolysaccharidoses 0.250775 0.601
R-HSA-9007101 Rab regulation of trafficking 0.088864 1.051
R-HSA-111885 Opioid Signalling 0.235199 0.629
R-HSA-111461 Cytochrome c-mediated apoptotic response 0.113275 0.946
R-HSA-418885 DCC mediated attractive signaling 0.141267 0.850
R-HSA-9679191 Potential therapeutics for SARS 0.152756 0.816
R-HSA-3247509 Chromatin modifying enzymes 0.147788 0.830
R-HSA-9006115 Signaling by NTRK2 (TRKB) 0.232512 0.634
R-HSA-9009391 Extra-nuclear estrogen signaling 0.226369 0.645
R-HSA-1640170 Cell Cycle 0.131761 0.880
R-HSA-73884 Base Excision Repair 0.188493 0.725
R-HSA-9694631 Maturation of nucleoprotein 0.175028 0.757
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.201085 0.697
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.111423 0.953
R-HSA-196807 Nicotinate metabolism 0.121863 0.914
R-HSA-2028269 Signaling by Hippo 0.161685 0.791
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 0.201085 0.697
R-HSA-376176 Signaling by ROBO receptors 0.103919 0.983
R-HSA-4839726 Chromatin organization 0.170474 0.768
R-HSA-1169408 ISG15 antiviral mechanism 0.143405 0.843
R-HSA-449836 Other interleukin signaling 0.175028 0.757
R-HSA-9860931 Response of endothelial cells to shear stress 0.235199 0.629
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.154459 0.811
R-HSA-69620 Cell Cycle Checkpoints 0.184642 0.734
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.160378 0.795
R-HSA-373080 Class B/2 (Secretin family receptors) 0.188493 0.725
R-HSA-193704 p75 NTR receptor-mediated signalling 0.220496 0.657
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.160047 0.796
R-HSA-5633007 Regulation of TP53 Activity 0.172022 0.764
R-HSA-72172 mRNA Splicing 0.267501 0.573
R-HSA-9855142 Cellular responses to mechanical stimuli 0.267702 0.572
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.274458 0.562
R-HSA-189483 Heme degradation 0.274458 0.562
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 0.280261 0.552
R-HSA-2142845 Hyaluronan metabolism 0.280261 0.552
R-HSA-1592230 Mitochondrial biogenesis 0.282491 0.549
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.286019 0.544
R-HSA-1852241 Organelle biogenesis and maintenance 0.290479 0.537
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.291731 0.535
R-HSA-212165 Epigenetic regulation of gene expression 0.295847 0.529
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.297397 0.527
R-HSA-196757 Metabolism of folate and pterines 0.297397 0.527
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.300205 0.523
R-HSA-422475 Axon guidance 0.301459 0.521
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.308595 0.511
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.308595 0.511
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.314128 0.503
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.314128 0.503
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.314128 0.503
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.314128 0.503
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.314128 0.503
R-HSA-167169 HIV Transcription Elongation 0.314128 0.503
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.314128 0.503
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.314128 0.503
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 0.319617 0.495
R-HSA-3214841 PKMTs methylate histone lysines 0.319617 0.495
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.324063 0.489
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.325062 0.488
R-HSA-167161 HIV Transcription Initiation 0.325062 0.488
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.325062 0.488
R-HSA-189451 Heme biosynthesis 0.325062 0.488
R-HSA-9683701 Translation of Structural Proteins 0.325062 0.488
R-HSA-9909396 Circadian clock 0.332477 0.478
R-HSA-73776 RNA Polymerase II Promoter Escape 0.335822 0.474
R-HSA-8854214 TBC/RABGAPs 0.335822 0.474
R-HSA-2172127 DAP12 interactions 0.341139 0.467
R-HSA-3928662 EPHB-mediated forward signaling 0.341139 0.467
R-HSA-373752 Netrin-1 signaling 0.341139 0.467
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.346413 0.460
R-HSA-6783310 Fanconi Anemia Pathway 0.346413 0.460
R-HSA-163685 Integration of energy metabolism 0.347017 0.460
R-HSA-3858494 Beta-catenin independent WNT signaling 0.347017 0.460
R-HSA-72165 mRNA Splicing - Minor Pathway 0.351645 0.454
R-HSA-9675108 Nervous system development 0.353749 0.451
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.356836 0.448
R-HSA-425410 Metal ion SLC transporters 0.361985 0.441
R-HSA-73893 DNA Damage Bypass 0.367094 0.435
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.367094 0.435
R-HSA-5658442 Regulation of RAS by GAPs 0.372162 0.429
R-HSA-9748787 Azathioprine ADME 0.372162 0.429
R-HSA-912446 Meiotic recombination 0.377189 0.423
R-HSA-5688426 Deubiquitination 0.378557 0.422
R-HSA-73772 RNA Polymerase I Promoter Escape 0.382177 0.418
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.382177 0.418
R-HSA-6794361 Neurexins and neuroligins 0.382177 0.418
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 0.382177 0.418
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.384303 0.415
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.387125 0.412
R-HSA-1221632 Meiotic synapsis 0.387125 0.412
R-HSA-9856651 MITF-M-dependent gene expression 0.389962 0.409
R-HSA-72649 Translation initiation complex formation 0.392034 0.407
R-HSA-446652 Interleukin-1 family signaling 0.395598 0.403
R-HSA-3214815 HDACs deacetylate histones 0.396904 0.401
R-HSA-9753281 Paracetamol ADME 0.396904 0.401
R-HSA-9012852 Signaling by NOTCH3 0.396904 0.401
R-HSA-416476 G alpha (q) signalling events 0.397996 0.400
R-HSA-73887 Death Receptor Signaling 0.401211 0.397
R-HSA-72702 Ribosomal scanning and start codon recognition 0.401735 0.396
R-HSA-193648 NRAGE signals death through JNK 0.401735 0.396
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.401735 0.396
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.401735 0.396
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.406527 0.391
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 0.411282 0.386
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.411282 0.386
R-HSA-194441 Metabolism of non-coding RNA 0.415999 0.381
R-HSA-191859 snRNP Assembly 0.415999 0.381
R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism 0.415999 0.381
R-HSA-76002 Platelet activation, signaling and aggregation 0.419406 0.377
R-HSA-8873719 RAB geranylgeranylation 0.420678 0.376
R-HSA-983189 Kinesins 0.420678 0.376
R-HSA-1660661 Sphingolipid de novo biosynthesis 0.420678 0.376
R-HSA-1227986 Signaling by ERBB2 0.420678 0.376
R-HSA-109581 Apoptosis 0.423414 0.373
R-HSA-74160 Gene expression (Transcription) 0.427720 0.369
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.430021 0.367
R-HSA-9658195 Leishmania infection 0.434248 0.362
R-HSA-9824443 Parasitic Infection Pathways 0.434248 0.362
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.434494 0.362
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.434494 0.362
R-HSA-8854518 AURKA Activation by TPX2 0.447982 0.349
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.447982 0.349
R-HSA-418555 G alpha (s) signalling events 0.450565 0.346
R-HSA-9664433 Leishmania parasite growth and survival 0.455910 0.341
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.455910 0.341
R-HSA-167172 Transcription of the HIV genome 0.456797 0.340
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.456797 0.340
R-HSA-5218859 Regulated Necrosis 0.456797 0.340
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.461225 0.336
R-HSA-9678108 SARS-CoV-1 Infection 0.461225 0.336
R-HSA-9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 0.465472 0.332
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.469758 0.328
R-HSA-427413 NoRC negatively regulates rRNA expression 0.469758 0.328
R-HSA-189445 Metabolism of porphyrins 0.469758 0.328
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.474009 0.324
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.478227 0.320
R-HSA-5663084 Diseases of carbohydrate metabolism 0.478227 0.320
R-HSA-201681 TCF dependent signaling in response to WNT 0.482182 0.317
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 0.482411 0.317
R-HSA-9013694 Signaling by NOTCH4 0.482411 0.317
R-HSA-380287 Centrosome maturation 0.486562 0.313
R-HSA-8852135 Protein ubiquitination 0.486562 0.313
R-HSA-917937 Iron uptake and transport 0.486562 0.313
R-HSA-1980143 Signaling by NOTCH1 0.490680 0.309
R-HSA-9679506 SARS-CoV Infections 0.491537 0.308
R-HSA-9694635 Translation of Structural Proteins 0.494765 0.306
R-HSA-383280 Nuclear Receptor transcription pathway 0.498818 0.302
R-HSA-5617833 Cilium Assembly 0.500108 0.301
R-HSA-168898 Toll-like Receptor Cascades 0.502637 0.299
R-HSA-9659379 Sensory processing of sound 0.502839 0.299
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.506827 0.295
R-HSA-9833482 PKR-mediated signaling 0.506827 0.295
R-HSA-1630316 Glycosaminoglycan metabolism 0.507670 0.294
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.518603 0.285
R-HSA-112315 Transmission across Chemical Synapses 0.519947 0.284
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.522466 0.282
R-HSA-1500620 Meiosis 0.526298 0.279
R-HSA-6794362 Protein-protein interactions at synapses 0.526298 0.279
R-HSA-5687128 MAPK6/MAPK4 signaling 0.526298 0.279
R-HSA-8953854 Metabolism of RNA 0.532391 0.274
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.533871 0.273
R-HSA-5357801 Programmed Cell Death 0.539573 0.268
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.541323 0.267
R-HSA-1236974 ER-Phagosome pathway 0.545005 0.264
R-HSA-112310 Neurotransmitter release cycle 0.548658 0.261
R-HSA-112316 Neuronal System 0.553040 0.257
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.555876 0.255
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.556157 0.255
R-HSA-9730414 MITF-M-regulated melanocyte development 0.558492 0.253
R-HSA-2682334 EPH-Ephrin signaling 0.559442 0.252
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.559442 0.252
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.562980 0.250
R-HSA-9837999 Mitochondrial protein degradation 0.566489 0.247
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.569971 0.244
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.569971 0.244
R-HSA-9748784 Drug ADME 0.570036 0.244
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.576851 0.239
R-HSA-8951664 Neddylation 0.576859 0.239
R-HSA-3214847 HATs acetylate histones 0.586966 0.231
R-HSA-8953897 Cellular responses to stimuli 0.594719 0.226
R-HSA-196854 Metabolism of vitamins and cofactors 0.596499 0.224
R-HSA-9842860 Regulation of endogenous retroelements 0.596842 0.224
R-HSA-9833110 RSV-host interactions 0.606483 0.217
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.609646 0.215
R-HSA-8939211 ESR-mediated signaling 0.611915 0.213
R-HSA-9692914 SARS-CoV-1-host interactions 0.612783 0.213
R-HSA-69239 Synthesis of DNA 0.615895 0.210
R-HSA-157118 Signaling by NOTCH 0.618239 0.209
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.618983 0.208
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.618983 0.208
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.618983 0.208
R-HSA-1236975 Antigen processing-Cross presentation 0.618983 0.208
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.625084 0.204
R-HSA-166166 MyD88-independent TLR4 cascade 0.625084 0.204
R-HSA-68886 M Phase 0.629208 0.201
R-HSA-913531 Interferon Signaling 0.630879 0.200
R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.631089 0.200
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.631089 0.200
R-HSA-5628897 TP53 Regulates Metabolic Genes 0.642813 0.192
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.645686 0.190
R-HSA-72737 Cap-dependent Translation Initiation 0.648536 0.188
R-HSA-72613 Eukaryotic Translation Initiation 0.648536 0.188
R-HSA-1280215 Cytokine Signaling in Immune system 0.656436 0.183
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.656950 0.182
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.656950 0.182
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.665164 0.177
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.665164 0.177
R-HSA-2132295 MHC class II antigen presentation 0.667858 0.175
R-HSA-194138 Signaling by VEGF 0.675813 0.170
R-HSA-114608 Platelet degranulation 0.681011 0.167
R-HSA-1474165 Reproduction 0.691159 0.160
R-HSA-69278 Cell Cycle, Mitotic 0.695667 0.158
R-HSA-8856688 Golgi-to-ER retrograde transport 0.696113 0.157
R-HSA-1474228 Degradation of the extracellular matrix 0.696113 0.157
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.698560 0.156
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.710506 0.148
R-HSA-9664417 Leishmania phagocytosis 0.717446 0.144
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.717446 0.144
R-HSA-9664407 Parasite infection 0.717446 0.144
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.719723 0.143
R-HSA-1632852 Macroautophagy 0.719723 0.143
R-HSA-1266738 Developmental Biology 0.721418 0.142
R-HSA-162599 Late Phase of HIV Life Cycle 0.724222 0.140
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.724222 0.140
R-HSA-73857 RNA Polymerase II Transcription 0.731108 0.136
R-HSA-2262752 Cellular responses to stress 0.733199 0.135
R-HSA-69242 S Phase 0.737293 0.132
R-HSA-166520 Signaling by NTRKs 0.737293 0.132
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.745664 0.127
R-HSA-69306 DNA Replication 0.747715 0.126
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.749749 0.125
R-HSA-9612973 Autophagy 0.753770 0.123
R-HSA-162587 HIV Life Cycle 0.755756 0.122
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.757726 0.120
R-HSA-449147 Signaling by Interleukins 0.764496 0.117
R-HSA-8957322 Metabolism of steroids 0.764593 0.117
R-HSA-109582 Hemostasis 0.777685 0.109
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.785455 0.105
R-HSA-199991 Membrane Trafficking 0.787861 0.104
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.788906 0.103
R-HSA-5683057 MAPK family signaling cascades 0.795174 0.100
R-HSA-9694516 SARS-CoV-2 Infection 0.797662 0.098
R-HSA-69275 G2/M Transition 0.808484 0.092
R-HSA-453274 Mitotic G2-G2/M phases 0.811567 0.091
R-HSA-9006931 Signaling by Nuclear Receptors 0.814344 0.089
R-HSA-68877 Mitotic Prometaphase 0.819061 0.087
R-HSA-212436 Generic Transcription Pathway 0.819865 0.086
R-HSA-9824446 Viral Infection Pathways 0.820540 0.086
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.829058 0.081
R-HSA-389948 Co-inhibition by PD-1 0.829058 0.081
R-HSA-428157 Sphingolipid metabolism 0.830441 0.081
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.833173 0.079
R-HSA-1483206 Glycerophospholipid biosynthesis 0.833173 0.079
R-HSA-425407 SLC-mediated transmembrane transport 0.850825 0.070
R-HSA-418594 G alpha (i) signalling events 0.859991 0.066
R-HSA-162906 HIV Infection 0.863855 0.064
R-HSA-9705683 SARS-CoV-2-host interactions 0.864958 0.063
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.866052 0.062
R-HSA-388396 GPCR downstream signalling 0.884999 0.053
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.886748 0.052
R-HSA-388841 Regulation of T cell activation by CD28 family 0.892491 0.049
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.897253 0.047
R-HSA-9734767 Developmental Cell Lineages 0.898455 0.047
R-HSA-5653656 Vesicle-mediated transport 0.903526 0.044
R-HSA-382551 Transport of small molecules 0.909056 0.041
R-HSA-162582 Signal Transduction 0.911989 0.040
R-HSA-5673001 RAF/MAP kinase cascade 0.917869 0.037
R-HSA-1483257 Phospholipid metabolism 0.921797 0.035
R-HSA-5684996 MAPK1/MAPK3 signaling 0.922434 0.035
R-HSA-372790 Signaling by GPCR 0.925624 0.034
R-HSA-597592 Post-translational protein modification 0.930446 0.031
R-HSA-5663205 Infectious disease 0.939245 0.027
R-HSA-1474244 Extracellular matrix organization 0.941746 0.026
R-HSA-500792 GPCR ligand binding 0.958280 0.019
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.962285 0.017
R-HSA-392499 Metabolism of proteins 0.962681 0.017
R-HSA-8978868 Fatty acid metabolism 0.969040 0.014
R-HSA-5668914 Diseases of metabolism 0.973741 0.012
R-HSA-72766 Translation 0.974171 0.011
R-HSA-1280218 Adaptive Immune System 0.974523 0.011
R-HSA-1643685 Disease 0.977907 0.010
R-HSA-6798695 Neutrophil degranulation 0.979497 0.009
R-HSA-556833 Metabolism of lipids 0.984636 0.007
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.987310 0.006
R-HSA-168256 Immune System 0.992591 0.003
R-HSA-168249 Innate Immune System 0.995652 0.002
R-HSA-1430728 Metabolism 0.999970 0.000
R-HSA-9709957 Sensory Perception 0.999972 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
JNK2JNK2 0.875 0.758 1 0.940
CDK8CDK8 0.873 0.652 1 0.945
JNK3JNK3 0.872 0.742 1 0.948
KISKIS 0.871 0.586 1 0.951
NLKNLK 0.871 0.613 1 0.895
CLK3CLK3 0.870 0.438 1 0.852
DYRK2DYRK2 0.869 0.632 1 0.946
CDK19CDK19 0.868 0.641 1 0.936
P38GP38G 0.868 0.723 1 0.909
CDK18CDK18 0.867 0.673 1 0.924
COTCOT 0.866 0.042 2 0.879
CDK7CDK7 0.866 0.639 1 0.950
CDK17CDK17 0.865 0.689 1 0.907
CDK1CDK1 0.863 0.659 1 0.935
CDK13CDK13 0.863 0.646 1 0.945
P38BP38B 0.862 0.685 1 0.916
CDK16CDK16 0.862 0.687 1 0.910
CDK5CDK5 0.861 0.635 1 0.939
ERK5ERK5 0.861 0.347 1 0.793
SRPK1SRPK1 0.861 0.312 -3 0.775
ERK1ERK1 0.861 0.666 1 0.924
P38DP38D 0.860 0.711 1 0.912
HIPK2HIPK2 0.860 0.620 1 0.942
ERK2ERK2 0.859 0.676 1 0.933
MTORMTOR 0.859 0.167 1 0.746
HIPK4HIPK4 0.858 0.365 1 0.885
DYRK4DYRK4 0.857 0.641 1 0.948
P38AP38A 0.857 0.650 1 0.928
CDK12CDK12 0.856 0.643 1 0.942
CDK3CDK3 0.856 0.608 1 0.913
CDK14CDK14 0.856 0.662 1 0.932
CDK9CDK9 0.854 0.629 1 0.945
HIPK1HIPK1 0.853 0.569 1 0.946
DYRK1BDYRK1B 0.853 0.609 1 0.936
CDK2CDK2 0.852 0.512 1 0.913
PIM3PIM3 0.852 0.039 -3 0.855
CDKL1CDKL1 0.852 0.146 -3 0.834
SRPK2SRPK2 0.851 0.256 -3 0.701
CDC7CDC7 0.851 -0.075 1 0.638
PRPKPRPK 0.850 -0.097 -1 0.857
ICKICK 0.850 0.298 -3 0.862
CDK10CDK10 0.849 0.625 1 0.934
DYRK1ADYRK1A 0.849 0.502 1 0.947
DSTYKDSTYK 0.849 -0.049 2 0.876
IKKBIKKB 0.849 -0.088 -2 0.765
CLK4CLK4 0.848 0.339 -3 0.784
CDKL5CDKL5 0.848 0.151 -3 0.827
NDR2NDR2 0.848 0.011 -3 0.853
RAF1RAF1 0.848 -0.127 1 0.650
JNK1JNK1 0.847 0.649 1 0.927
PKN3PKN3 0.847 0.022 -3 0.854
CLK1CLK1 0.847 0.360 -3 0.753
CAMK1BCAMK1B 0.847 0.011 -3 0.883
ULK2ULK2 0.847 -0.134 2 0.785
TBK1TBK1 0.846 -0.136 1 0.578
PDHK4PDHK4 0.845 -0.180 1 0.702
NUAK2NUAK2 0.845 0.049 -3 0.854
CAMK2GCAMK2G 0.845 -0.038 2 0.799
GCN2GCN2 0.844 -0.203 2 0.790
MOSMOS 0.844 -0.055 1 0.691
HIPK3HIPK3 0.844 0.537 1 0.930
PIM1PIM1 0.844 0.090 -3 0.802
WNK1WNK1 0.844 -0.017 -2 0.874
DYRK3DYRK3 0.844 0.469 1 0.933
BMPR2BMPR2 0.844 -0.152 -2 0.879
CLK2CLK2 0.843 0.378 -3 0.763
PKCDPKCD 0.843 0.038 2 0.791
RSK2RSK2 0.842 0.050 -3 0.784
IKKEIKKE 0.842 -0.147 1 0.572
NDR1NDR1 0.842 -0.006 -3 0.850
RIPK3RIPK3 0.841 -0.092 3 0.728
CDK4CDK4 0.841 0.647 1 0.935
PRKD1PRKD1 0.841 0.008 -3 0.834
ATRATR 0.841 -0.064 1 0.659
CDK6CDK6 0.841 0.625 1 0.929
IKKAIKKA 0.841 -0.018 -2 0.753
NIKNIK 0.841 -0.027 -3 0.898
PKN2PKN2 0.840 -0.008 -3 0.858
NEK6NEK6 0.840 -0.074 -2 0.853
SRPK3SRPK3 0.840 0.206 -3 0.756
P90RSKP90RSK 0.840 0.035 -3 0.795
NEK7NEK7 0.840 -0.142 -3 0.863
MST4MST4 0.840 -0.027 2 0.837
HUNKHUNK 0.839 -0.079 2 0.810
CAMLCKCAMLCK 0.839 0.007 -2 0.851
PDHK1PDHK1 0.839 -0.192 1 0.680
MAPKAPK3MAPKAPK3 0.839 0.008 -3 0.793
TGFBR2TGFBR2 0.839 -0.079 -2 0.784
LATS2LATS2 0.838 0.008 -5 0.828
MARK4MARK4 0.838 -0.034 4 0.793
ULK1ULK1 0.838 -0.143 -3 0.845
AMPKA1AMPKA1 0.838 -0.015 -3 0.867
MLK1MLK1 0.838 -0.116 2 0.811
PRKD2PRKD2 0.837 0.025 -3 0.767
SKMLCKSKMLCK 0.837 -0.028 -2 0.855
GRK6GRK6 0.837 0.003 1 0.641
GRK5GRK5 0.837 -0.099 -3 0.894
PRP4PRP4 0.837 0.376 -3 0.785
MAPKAPK2MAPKAPK2 0.837 0.045 -3 0.744
TSSK2TSSK2 0.836 -0.007 -5 0.858
WNK3WNK3 0.835 -0.174 1 0.644
P70S6KBP70S6KB 0.835 0.017 -3 0.816
RSK3RSK3 0.835 0.008 -3 0.784
CAMK2DCAMK2D 0.834 -0.052 -3 0.861
IRE1IRE1 0.834 -0.057 1 0.639
TSSK1TSSK1 0.833 -0.011 -3 0.878
DAPK2DAPK2 0.833 -0.049 -3 0.889
RIPK1RIPK1 0.833 -0.150 1 0.655
FAM20CFAM20C 0.832 0.051 2 0.628
NEK9NEK9 0.832 -0.161 2 0.821
DLKDLK 0.832 -0.133 1 0.664
AMPKA2AMPKA2 0.832 -0.013 -3 0.833
CHAK2CHAK2 0.832 -0.093 -1 0.851
BCKDKBCKDK 0.832 -0.158 -1 0.810
NUAK1NUAK1 0.832 -0.004 -3 0.804
PKACGPKACG 0.831 -0.014 -2 0.731
NIM1NIM1 0.831 -0.071 3 0.769
CAMK2BCAMK2B 0.830 0.015 2 0.775
PLK1PLK1 0.830 -0.050 -2 0.812
BMPR1BBMPR1B 0.830 0.031 1 0.593
GRK1GRK1 0.829 -0.023 -2 0.767
IRE2IRE2 0.829 -0.051 2 0.759
MLK2MLK2 0.829 -0.131 2 0.810
MLK3MLK3 0.829 -0.038 2 0.736
MELKMELK 0.829 -0.028 -3 0.818
ANKRD3ANKRD3 0.829 -0.156 1 0.677
TGFBR1TGFBR1 0.828 0.006 -2 0.801
PKCBPKCB 0.828 0.002 2 0.736
CAMK4CAMK4 0.828 -0.085 -3 0.837
ATMATM 0.828 -0.070 1 0.596
ALK4ALK4 0.828 -0.018 -2 0.824
PAK1PAK1 0.827 -0.026 -2 0.791
MSK2MSK2 0.827 -0.013 -3 0.773
ERK7ERK7 0.827 0.230 2 0.550
PKRPKR 0.827 -0.041 1 0.671
PKCAPKCA 0.827 -0.003 2 0.726
AURCAURC 0.827 0.015 -2 0.648
GRK4GRK4 0.827 -0.122 -2 0.807
CAMK2ACAMK2A 0.827 0.018 2 0.790
PAK3PAK3 0.827 -0.057 -2 0.794
MASTLMASTL 0.826 -0.247 -2 0.812
PRKD3PRKD3 0.826 0.012 -3 0.751
RSK4RSK4 0.826 0.044 -3 0.755
PKCGPKCG 0.826 -0.018 2 0.730
LATS1LATS1 0.826 0.015 -3 0.860
GRK7GRK7 0.825 0.059 1 0.615
QSKQSK 0.824 -0.028 4 0.778
MNK2MNK2 0.824 -0.036 -2 0.792
QIKQIK 0.824 -0.089 -3 0.857
MAKMAK 0.824 0.409 -2 0.736
MLK4MLK4 0.824 -0.073 2 0.731
PHKG1PHKG1 0.824 -0.059 -3 0.835
DNAPKDNAPK 0.824 -0.020 1 0.566
TTBK2TTBK2 0.824 -0.188 2 0.669
PKCHPKCH 0.824 -0.030 2 0.722
VRK2VRK2 0.823 -0.039 1 0.740
PLK3PLK3 0.822 -0.046 2 0.761
SIKSIK 0.822 -0.024 -3 0.775
CHK1CHK1 0.822 -0.013 -3 0.844
MSK1MSK1 0.822 0.010 -3 0.782
PKACBPKACB 0.822 0.038 -2 0.673
MEK1MEK1 0.821 -0.131 2 0.840
MOKMOK 0.821 0.395 1 0.878
MYLK4MYLK4 0.821 -0.011 -2 0.775
MARK3MARK3 0.821 -0.013 4 0.736
MARK2MARK2 0.821 -0.026 4 0.697
NEK2NEK2 0.821 -0.121 2 0.792
PIM2PIM2 0.821 0.056 -3 0.768
PINK1PINK1 0.821 0.091 1 0.788
SGK3SGK3 0.821 0.023 -3 0.790
ALK2ALK2 0.820 -0.018 -2 0.809
YSK4YSK4 0.820 -0.161 1 0.609
AURBAURB 0.820 -0.007 -2 0.649
PKCZPKCZ 0.820 -0.052 2 0.772
AKT2AKT2 0.820 0.049 -3 0.705
PAK2PAK2 0.820 -0.062 -2 0.774
PKG2PKG2 0.819 -0.001 -2 0.666
BRAFBRAF 0.818 -0.057 -4 0.861
PAK6PAK6 0.818 -0.024 -2 0.713
GSK3AGSK3A 0.818 0.163 4 0.441
ACVR2AACVR2A 0.818 -0.056 -2 0.777
MNK1MNK1 0.818 -0.038 -2 0.797
BRSK1BRSK1 0.818 -0.060 -3 0.805
TLK2TLK2 0.817 -0.113 1 0.622
PRKXPRKX 0.817 0.057 -3 0.690
DRAK1DRAK1 0.816 -0.085 1 0.596
ACVR2BACVR2B 0.816 -0.070 -2 0.794
MAPKAPK5MAPKAPK5 0.816 -0.072 -3 0.755
BRSK2BRSK2 0.815 -0.104 -3 0.830
SMG1SMG1 0.815 -0.116 1 0.615
PKCTPKCT 0.815 -0.022 2 0.732
CAMK1GCAMK1G 0.815 -0.027 -3 0.777
PLK4PLK4 0.815 -0.116 2 0.621
MARK1MARK1 0.815 -0.054 4 0.752
IRAK4IRAK4 0.815 -0.086 1 0.627
WNK4WNK4 0.815 -0.102 -2 0.865
ZAKZAK 0.814 -0.121 1 0.634
CHAK1CHAK1 0.814 -0.172 2 0.741
BMPR1ABMPR1A 0.814 0.009 1 0.575
MEKK3MEKK3 0.812 -0.154 1 0.643
HRIHRI 0.812 -0.189 -2 0.840
AKT1AKT1 0.812 0.034 -3 0.720
GRK2GRK2 0.811 -0.079 -2 0.703
DCAMKL1DCAMKL1 0.811 -0.042 -3 0.783
AURAAURA 0.811 -0.025 -2 0.619
PERKPERK 0.811 -0.170 -2 0.821
MEKK1MEKK1 0.810 -0.183 1 0.650
SSTKSSTK 0.810 -0.043 4 0.758
MEK5MEK5 0.810 -0.208 2 0.822
MEKK2MEKK2 0.810 -0.122 2 0.801
SNRKSNRK 0.810 -0.194 2 0.671
MST3MST3 0.810 -0.051 2 0.821
SMMLCKSMMLCK 0.809 -0.025 -3 0.843
NEK5NEK5 0.809 -0.146 1 0.643
MPSK1MPSK1 0.809 -0.010 1 0.665
GSK3BGSK3B 0.809 0.024 4 0.434
P70S6KP70S6K 0.808 -0.015 -3 0.737
PKCIPKCI 0.808 -0.019 2 0.747
PASKPASK 0.808 -0.014 -3 0.873
PHKG2PHKG2 0.806 -0.081 -3 0.801
IRAK1IRAK1 0.806 -0.176 -1 0.794
CAMKK1CAMKK1 0.806 -0.107 -2 0.798
GAKGAK 0.806 -0.007 1 0.661
DCAMKL2DCAMKL2 0.806 -0.064 -3 0.807
TLK1TLK1 0.805 -0.166 -2 0.824
CAMK1DCAMK1D 0.805 -0.006 -3 0.700
PKACAPKACA 0.805 0.013 -2 0.616
TAO3TAO3 0.804 -0.087 1 0.653
CK2A2CK2A2 0.804 0.077 1 0.519
PKCEPKCE 0.803 0.011 2 0.715
NEK8NEK8 0.803 -0.147 2 0.806
CK1ECK1E 0.803 -0.037 -3 0.584
LKB1LKB1 0.802 -0.046 -3 0.857
PKN1PKN1 0.802 -0.007 -3 0.744
TTBK1TTBK1 0.801 -0.167 2 0.591
CAMKK2CAMKK2 0.800 -0.104 -2 0.785
NEK11NEK11 0.800 -0.172 1 0.654
PAK5PAK5 0.800 -0.049 -2 0.644
AKT3AKT3 0.799 0.046 -3 0.640
TAO2TAO2 0.799 -0.111 2 0.832
PDK1PDK1 0.799 -0.085 1 0.670
SGK1SGK1 0.799 0.057 -3 0.633
TAK1TAK1 0.798 -0.110 1 0.642
CK1DCK1D 0.797 -0.012 -3 0.536
NEK4NEK4 0.797 -0.157 1 0.615
GRK3GRK3 0.796 -0.075 -2 0.655
HGKHGK 0.796 -0.098 3 0.816
SBKSBK 0.795 0.111 -3 0.575
CK1G1CK1G1 0.795 -0.073 -3 0.574
MEKK6MEKK6 0.795 -0.127 1 0.630
CHK2CHK2 0.795 -0.002 -3 0.644
DAPK3DAPK3 0.795 -0.035 -3 0.810
PAK4PAK4 0.794 -0.050 -2 0.646
MST2MST2 0.794 -0.149 1 0.622
MRCKBMRCKB 0.794 0.017 -3 0.757
MRCKAMRCKA 0.794 0.016 -3 0.772
VRK1VRK1 0.794 -0.134 2 0.848
EEF2KEEF2K 0.794 -0.093 3 0.805
GCKGCK 0.794 -0.116 1 0.631
MINKMINK 0.793 -0.132 1 0.616
TNIKTNIK 0.793 -0.076 3 0.812
PLK2PLK2 0.793 -0.041 -3 0.816
CK2A1CK2A1 0.793 0.056 1 0.502
ROCK2ROCK2 0.793 0.018 -3 0.809
LRRK2LRRK2 0.792 -0.105 2 0.827
MAP3K15MAP3K15 0.792 -0.153 1 0.630
CAMK1ACAMK1A 0.792 -0.004 -3 0.658
CK1A2CK1A2 0.792 -0.035 -3 0.534
NEK1NEK1 0.792 -0.146 1 0.625
LOKLOK 0.792 -0.097 -2 0.760
RIPK2RIPK2 0.790 -0.215 1 0.603
HPK1HPK1 0.790 -0.106 1 0.623
PDHK3_TYRPDHK3_TYR 0.788 0.156 4 0.854
DAPK1DAPK1 0.788 -0.040 -3 0.801
DMPK1DMPK1 0.787 0.054 -3 0.760
YSK1YSK1 0.787 -0.115 2 0.793
BUB1BUB1 0.787 0.003 -5 0.819
MST1MST1 0.786 -0.159 1 0.610
STK33STK33 0.786 -0.158 2 0.596
PBKPBK 0.786 -0.061 1 0.587
KHS2KHS2 0.786 -0.053 1 0.629
KHS1KHS1 0.786 -0.094 1 0.615
NEK3NEK3 0.785 -0.134 1 0.622
SLKSLK 0.784 -0.116 -2 0.692
HASPINHASPIN 0.784 -0.000 -1 0.706
MEK2MEK2 0.783 -0.234 2 0.802
PKG1PKG1 0.782 -0.031 -2 0.587
TESK1_TYRTESK1_TYR 0.780 -0.008 3 0.855
ROCK1ROCK1 0.780 0.002 -3 0.772
TTKTTK 0.779 -0.078 -2 0.814
PDHK4_TYRPDHK4_TYR 0.779 0.049 2 0.875
OSR1OSR1 0.779 -0.087 2 0.804
CRIKCRIK 0.778 0.018 -3 0.720
PKMYT1_TYRPKMYT1_TYR 0.778 0.027 3 0.824
LIMK2_TYRLIMK2_TYR 0.778 0.075 -3 0.904
BIKEBIKE 0.777 -0.037 1 0.567
MAP2K7_TYRMAP2K7_TYR 0.775 -0.125 2 0.844
MAP2K6_TYRMAP2K6_TYR 0.775 -0.015 -1 0.852
MAP2K4_TYRMAP2K4_TYR 0.775 -0.078 -1 0.855
ALPHAK3ALPHAK3 0.774 -0.069 -1 0.755
PINK1_TYRPINK1_TYR 0.773 -0.135 1 0.696
ASK1ASK1 0.773 -0.155 1 0.625
BMPR2_TYRBMPR2_TYR 0.773 -0.028 -1 0.821
PDHK1_TYRPDHK1_TYR 0.772 -0.064 -1 0.861
MYO3BMYO3B 0.772 -0.099 2 0.799
MYO3AMYO3A 0.772 -0.104 1 0.634
RETRET 0.770 -0.123 1 0.652
LIMK1_TYRLIMK1_TYR 0.768 -0.086 2 0.837
TAO1TAO1 0.767 -0.147 1 0.600
CSF1RCSF1R 0.766 -0.104 3 0.765
TYRO3TYRO3 0.764 -0.166 3 0.771
TYK2TYK2 0.764 -0.227 1 0.639
EPHA6EPHA6 0.763 -0.116 -1 0.826
MST1RMST1R 0.763 -0.170 3 0.771
AAK1AAK1 0.762 -0.006 1 0.496
DDR1DDR1 0.762 -0.149 4 0.747
JAK2JAK2 0.762 -0.177 1 0.652
ROS1ROS1 0.762 -0.181 3 0.749
STLK3STLK3 0.762 -0.173 1 0.600
NEK10_TYRNEK10_TYR 0.761 -0.094 1 0.574
TXKTXK 0.761 -0.037 1 0.605
YES1YES1 0.760 -0.074 -1 0.848
YANK3YANK3 0.760 -0.105 2 0.382
EPHB4EPHB4 0.760 -0.149 -1 0.823
JAK3JAK3 0.759 -0.151 1 0.644
TNNI3K_TYRTNNI3K_TYR 0.759 -0.042 1 0.669
FGFR2FGFR2 0.759 -0.083 3 0.766
FGFR1FGFR1 0.758 -0.070 3 0.746
ABL2ABL2 0.757 -0.128 -1 0.828
KITKIT 0.756 -0.134 3 0.767
INSRRINSRR 0.756 -0.151 3 0.732
PDGFRBPDGFRB 0.756 -0.198 3 0.777
TNK1TNK1 0.756 -0.105 3 0.751
TEKTEK 0.756 -0.071 3 0.713
ITKITK 0.755 -0.111 -1 0.809
FLT3FLT3 0.755 -0.167 3 0.763
KDRKDR 0.754 -0.117 3 0.734
FERFER 0.754 -0.207 1 0.628
TNK2TNK2 0.754 -0.152 3 0.715
FGRFGR 0.753 -0.196 1 0.620
SRMSSRMS 0.753 -0.148 1 0.613
CK1ACK1A 0.753 -0.069 -3 0.441
ABL1ABL1 0.753 -0.138 -1 0.831
JAK1JAK1 0.753 -0.130 1 0.607
AXLAXL 0.752 -0.168 3 0.749
EPHA4EPHA4 0.752 -0.122 2 0.765
EPHB1EPHB1 0.752 -0.168 1 0.617
LCKLCK 0.751 -0.103 -1 0.818
HCKHCK 0.751 -0.164 -1 0.816
WEE1_TYRWEE1_TYR 0.751 -0.090 -1 0.777
TECTEC 0.750 -0.115 -1 0.765
EPHB3EPHB3 0.749 -0.175 -1 0.814
MERTKMERTK 0.748 -0.166 3 0.744
EPHB2EPHB2 0.748 -0.155 -1 0.809
DDR2DDR2 0.747 -0.053 3 0.714
PDGFRAPDGFRA 0.747 -0.252 3 0.767
BLKBLK 0.747 -0.095 -1 0.812
FGFR3FGFR3 0.746 -0.109 3 0.742
BTKBTK 0.746 -0.208 -1 0.790
BMXBMX 0.746 -0.117 -1 0.716
FLT1FLT1 0.746 -0.148 -1 0.799
FLT4FLT4 0.745 -0.167 3 0.732
METMET 0.744 -0.170 3 0.743
PTK6PTK6 0.743 -0.220 -1 0.783
ALKALK 0.743 -0.202 3 0.699
ERBB2ERBB2 0.742 -0.198 1 0.598
FYNFYN 0.741 -0.085 -1 0.781
LTKLTK 0.741 -0.200 3 0.720
NTRK1NTRK1 0.741 -0.251 -1 0.816
EPHA7EPHA7 0.741 -0.165 2 0.767
NTRK2NTRK2 0.740 -0.230 3 0.727
FRKFRK 0.739 -0.171 -1 0.827
PTK2BPTK2B 0.739 -0.102 -1 0.826
INSRINSR 0.739 -0.206 3 0.704
MATKMATK 0.738 -0.131 -1 0.766
CK1G3CK1G3 0.738 -0.062 -3 0.395
EPHA1EPHA1 0.737 -0.208 3 0.721
EGFREGFR 0.736 -0.126 1 0.533
LYNLYN 0.736 -0.156 3 0.695
EPHA3EPHA3 0.736 -0.207 2 0.736
NTRK3NTRK3 0.736 -0.192 -1 0.770
FGFR4FGFR4 0.735 -0.117 -1 0.772
CSKCSK 0.733 -0.172 2 0.763
EPHA5EPHA5 0.732 -0.173 2 0.756
SRCSRC 0.732 -0.127 -1 0.798
EPHA8EPHA8 0.730 -0.168 -1 0.776
YANK2YANK2 0.728 -0.126 2 0.402
PTK2PTK2 0.725 -0.106 -1 0.705
MUSKMUSK 0.725 -0.184 1 0.511
SYKSYK 0.722 -0.126 -1 0.706
IGF1RIGF1R 0.720 -0.207 3 0.648
ERBB4ERBB4 0.719 -0.134 1 0.527
EPHA2EPHA2 0.719 -0.183 -1 0.731
FESFES 0.709 -0.184 -1 0.720
CK1G2CK1G2 0.705 -0.110 -3 0.489
ZAP70ZAP70 0.704 -0.112 -1 0.644