Motif 118 (n=122)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A2A3K4 | PTPDC1 | S472 | ochoa | Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) | May play roles in cilia formation and/or maintenance. {ECO:0000250}. |
A6H8Y1 | BDP1 | S1403 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
O00444 | PLK4 | S421 | ochoa | Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}. |
O15042 | U2SURP | S818 | ochoa | U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) | None |
O43149 | ZZEF1 | S240 | ochoa | Zinc finger ZZ-type and EF-hand domain-containing protein 1 | Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors. {ECO:0000269|PubMed:33227311}. |
O75044 | SRGAP2 | S424 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
O75128 | COBL | S741 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
O75167 | PHACTR2 | S237 | ochoa | Phosphatase and actin regulator 2 | None |
O94929 | ABLIM3 | S163 | ochoa | Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
O95235 | KIF20A | S254 | ochoa | Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) | Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}. |
O95359 | TACC2 | S2366 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
O95402 | MED26 | S447 | ochoa | Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
O95466 | FMNL1 | S950 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
O95677 | EYA4 | S37 | ochoa | Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4) | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}. |
P0DJJ0 | SRGAP2C | S424 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1) | Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291). {ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212, ECO:0000269|PubMed:31822692, ECO:0000269|PubMed:34707291}. |
P0DMB2 | C8orf88 | S70 | ochoa | Uncharacterized protein C8orf88 | None |
P0DMP2 | SRGAP2B | S423 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2B (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2) | May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692). In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692). {ECO:0000269|PubMed:31822692, ECO:0000305|PubMed:22559944, ECO:0000305|PubMed:31822692}. |
P10827 | THRA | S21 | ochoa | Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) | [Isoform Alpha-1]: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:19926848}.; FUNCTION: [Isoform Alpha-2]: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. {ECO:0000269|PubMed:8910441}. |
P17948 | FLT1 | S1003 | ochoa | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. |
P19447 | ERCC3 | S231 | ochoa | General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) | ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:17466626, ECO:0000269|PubMed:30894545, ECO:0000269|PubMed:31253769, ECO:0000269|PubMed:33902107, ECO:0000269|PubMed:7724549, ECO:0000269|PubMed:8157004, ECO:0000269|PubMed:8663148, ECO:0000305|PubMed:8465201}. |
P19634 | SLC9A1 | S605 | ochoa | Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250|UniProtKB:P26431, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:11532004, ECO:0000269|PubMed:12947095, ECO:0000269|PubMed:14680478, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:15096511, ECO:0000269|PubMed:15677483, ECO:0000269|PubMed:17073455, ECO:0000269|PubMed:17493937, ECO:0000269|PubMed:22020933, ECO:0000269|PubMed:27650500, ECO:0000269|PubMed:32130622, ECO:0000269|PubMed:7110335, ECO:0000269|PubMed:7603840, ECO:0000269|PubMed:8901634}. |
P24278 | ZBTB25 | S342 | ochoa | Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP) | May be involved in transcriptional regulation. |
P25054 | APC | S2621 | ochoa | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}. |
P29374 | ARID4A | S1145 | ochoa|psp | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:F8VPQ2, ECO:0000269|PubMed:14581478}. |
P35251 | RFC1 | Y106 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
P35251 | RFC1 | S518 | psp | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
P38398 | BRCA1 | S1191 | ochoa|psp | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}. |
P42574 | CASP3 | S24 | ochoa | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity). Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430). Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106). {ECO:0000250|UniProtKB:Q60431, ECO:0000269|PubMed:10497198, ECO:0000269|PubMed:16374543, ECO:0000269|PubMed:18723680, ECO:0000269|PubMed:20566630, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:23650375, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:30878284, ECO:0000269|PubMed:33725486, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758106, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9334240}. |
P46013 | MKI67 | S3082 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46100 | ATRX | S316 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P62879 | GNB2 | S136 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
P78344 | EIF4G2 | S443 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
P80192 | MAP3K9 | S693 | ochoa | Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}. |
Q03468 | ERCC6 | S1146 | ochoa | DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) | Essential factor involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes (PubMed:16246722, PubMed:20541997, PubMed:22483866, PubMed:26620705, PubMed:32355176, PubMed:34526721, PubMed:38316879, PubMed:38600235, PubMed:38600236). Plays a central role in the initiation of the TC-NER process: specifically recognizes and binds RNA polymerase II stalled at a lesion, and mediates recruitment of ERCC8/CSA, initiating DNA damage excision by TFIIH recruitment (PubMed:32355176, PubMed:34526721, PubMed:38600235, PubMed:38600236). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (PubMed:15548521). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (PubMed:16246722, PubMed:9565609). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (PubMed:25820262). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (PubMed:25820262). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing premature entry of cells into mitosis following the induction of DNA DSBs (PubMed:25820262). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (PubMed:29203878). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (PubMed:28292928). Also involved in UV-induced translocation of ERCC8 to the nuclear matrix (PubMed:26620705). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (PubMed:24874740). {ECO:0000269|PubMed:15548521, ECO:0000269|PubMed:16246722, ECO:0000269|PubMed:20541997, ECO:0000269|PubMed:22483866, ECO:0000269|PubMed:24874740, ECO:0000269|PubMed:25820262, ECO:0000269|PubMed:26620705, ECO:0000269|PubMed:28292928, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:34526721, ECO:0000269|PubMed:38316879, ECO:0000269|PubMed:38600235, ECO:0000269|PubMed:38600236, ECO:0000269|PubMed:9565609}. |
Q04727 | TLE4 | S208 | ochoa | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}. |
Q06187 | BTK | S323 | ochoa | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
Q12830 | BPTF | S737 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
Q12888 | TP53BP1 | S1288 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
Q13009 | TIAM1 | S298 | ochoa | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
Q14191 | WRN | S1399 | ochoa | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). Has no nuclease activity towards single-stranded (ss)DNA or blunt-ended dsDNA (PubMed:11863428). Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) (PubMed:9611231). Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (PubMed:9224595, PubMed:9288107, PubMed:9611231). Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity to assemble into tetraplex structures; other G-rich substrates from a telomeric or IgG switch sequence are not unwound (PubMed:10212265). Depletion leads to chromosomal breaks and genome instability (PubMed:33199508). {ECO:0000250|UniProtKB:O09053, ECO:0000269|PubMed:10212265, ECO:0000269|PubMed:11863428, ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:18596042, ECO:0000269|PubMed:19283071, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:33199508, ECO:0000269|PubMed:9224595, ECO:0000269|PubMed:9288107, ECO:0000269|PubMed:9611231}. |
Q14938 | NFIX | S288 | ochoa | Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) | Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
Q14966 | ZNF638 | S585 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
Q149N8 | SHPRH | S93 | ochoa | E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase) | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:18719106}. |
Q15047 | SETDB1 | S1066 | ochoa|psp | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:O88974, ECO:0000269|PubMed:12869583, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:27237050, ECO:0000269|PubMed:27732843, ECO:0000269|PubMed:39096901}. |
Q16181 | SEPTIN7 | S77 | ochoa | Septin-7 (CDC10 protein homolog) | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18460473, ECO:0000305|PubMed:25588830}. |
Q16236 | NFE2L2 | S215 | ochoa|psp | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) | Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. |
Q3KR37 | GRAMD1B | S274 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
Q3L8U1 | CHD9 | S2079 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
Q4G0N4 | NADK2 | S376 | psp | NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial) | Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}. |
Q5CZC0 | FSIP2 | S3898 | ochoa | Fibrous sheath-interacting protein 2 | Plays a role in spermatogenesis. {ECO:0000305|PubMed:30137358}. |
Q5JWR5 | DOP1A | S1023 | ochoa | Protein DOP1A | May be involved in protein traffic between late Golgi and early endosomes. {ECO:0000250|UniProtKB:Q03921}. |
Q5T7B8 | KIF24 | S646 | ochoa | Kinesin-like protein KIF24 | Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385). {ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:26290419, ECO:0000269|PubMed:30375385}. |
Q5UIP0 | RIF1 | S1772 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
Q63HK5 | TSHZ3 | S515 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
Q68CP4 | HGSNAT | S243 | ochoa | Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) | Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:19823584, ECO:0000269|PubMed:20650889}. |
Q68E01 | INTS3 | S995 | ochoa | Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS3 is involved in the post-termination step: INTS3 binds INTS7 in the open conformation of integrator complex and prevents the rebinding of Pol II to the integrator after termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
Q6KC79 | NIPBL | S850 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
Q6RI45 | BRWD3 | S1386 | ochoa | Bromodomain and WD repeat-containing protein 3 | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}. |
Q6UB99 | ANKRD11 | S276 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
Q6ZSB9 | ZBTB49 | S178 | ochoa | Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) | Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 1]: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive). {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter. {ECO:0000269|PubMed:25245946}. |
Q6ZSB9 | ZBTB49 | S592 | ochoa | Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) | Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 1]: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive). {ECO:0000269|PubMed:25245946}.; FUNCTION: [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter. {ECO:0000269|PubMed:25245946}. |
Q7Z401 | DENND4A | S963 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
Q7Z6B7 | SRGAP1 | S413 | ochoa | SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}. |
Q86SQ0 | PHLDB2 | S294 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
Q86UR5 | RIMS1 | S999 | ochoa | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) | Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}. |
Q86W56 | PARG | S323 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
Q86XP3 | DDX42 | S831 | ochoa | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures (PubMed:16397294). Unwinding is promoted in the presence of single-strand binding proteins (PubMed:16397294). Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein (PubMed:16397294). ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands (PubMed:16397294). Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP (PubMed:12234937, PubMed:36797247). Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 (PubMed:19377511). Relocalizes TP53BP2 to the cytoplasm (PubMed:19377511). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511, ECO:0000269|PubMed:36797247}. |
Q8IX21 | SLF2 | S340 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
Q8IYD8 | FANCM | S1045 | psp | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) | DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:29231814}. |
Q8IYH5 | ZZZ3 | S426 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
Q8N4S0 | CCDC82 | S88 | ochoa | Coiled-coil domain-containing protein 82 | None |
Q8NDI1 | EHBP1 | S578 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
Q92574 | TSC1 | S270 | ochoa | Hamartin (Tuberous sclerosis 1 protein) | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12271141, PubMed:24529379, PubMed:28215400, PubMed:33215753). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Within the TSC-TBC complex, TSC1 stabilizes TSC2 and prevents TSC2 self-aggregation (PubMed:10585443, PubMed:28215400). Acts as a tumor suppressor (PubMed:9242607). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155). {ECO:0000250|UniProtKB:Q9Z136, ECO:0000269|PubMed:10585443, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12906785, ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:16464865, ECO:0000269|PubMed:24529379, ECO:0000269|PubMed:28215400, ECO:0000269|PubMed:29127155, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:9242607}. |
Q96BK5 | PINX1 | S117 | psp | PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) | Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}. |
Q96CM8 | ACSF2 | S52 | ochoa | Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2) | Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219). {ECO:0000269|PubMed:16380219, ECO:0000269|PubMed:17762044}. |
Q96DU3 | SLAMF6 | S291 | ochoa | SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352) | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:16920955, PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q9ET39, ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:16920955, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}. |
Q96IZ7 | RSRC1 | S239 | ochoa | Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) | Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. {ECO:0000269|PubMed:15798186, ECO:0000269|PubMed:29522154}. |
Q96JM3 | CHAMP1 | S675 | ochoa | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. |
Q96M89 | CCDC138 | S49 | ochoa | Coiled-coil domain-containing protein 138 | None |
Q96NJ6 | ZFP3 | S63 | ochoa | Zinc finger protein 3 homolog (Zfp-3) (Zinc finger protein 752) | May be involved in transcriptional regulation. |
Q96PZ2 | FAM111A | S26 | ochoa | Serine protease FAM111A (EC 3.4.21.-) | Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:32165630). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:32165630). Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors (PubMed:32165630). Required for PCNA loading on replication sites (PubMed:24561620). Promotes S-phase entry and DNA synthesis (PubMed:24561620). Also acts as a restriction factor for some viruses including SV40 polyomavirus and vaccinia virus (PubMed:23093934, PubMed:37607234). Mechanistically, affects nuclear barrier function during viral replication by mediating the disruption of the nuclear pore complex (NPC) via its protease activity (PubMed:33369867, PubMed:37607234). In turn, interacts with vaccinia virus DNA-binding protein OPG079 in the cytoplasm and promotes its degradation without the need of its protease activity but through autophagy (PubMed:37607234). {ECO:0000269|PubMed:24561620, ECO:0000269|PubMed:32165630, ECO:0000269|PubMed:37607234}. |
Q96RS0 | TGS1 | S154 | ochoa | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N(2) methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. {ECO:0000269|PubMed:11517327, ECO:0000269|PubMed:11912212, ECO:0000269|PubMed:16687569, ECO:0000269|PubMed:18775984}. |
Q96T37 | RBM15 | S182 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
Q96T58 | SPEN | S1062 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
Q99675 | CGRRF1 | S252 | ochoa | Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) (RING finger protein 197) | Able to inhibit growth in several cell lines. {ECO:0000250|UniProtKB:P97587}. |
Q99808 | SLC29A1 | S271 | ochoa | Equilibrative nucleoside transporter 1 (hENT1) (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (es nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189). {ECO:0000250|UniProtKB:O54698, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:10755314, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:14759222, ECO:0000269|PubMed:15037197, ECO:0000269|PubMed:17379602, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:26406980, ECO:0000269|PubMed:27995448, ECO:0000269|PubMed:35790189, ECO:0000269|PubMed:8986748}. |
Q9BY42 | RTF2 | S235 | ochoa | Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1) | Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
Q9H0G5 | NSRP1 | S291 | ochoa | Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. {ECO:0000269|PubMed:21296756}. |
Q9H2P0 | ADNP | S970 | ochoa | Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein) | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity). {ECO:0000250|UniProtKB:Q9Z103}. |
Q9H2Y7 | ZNF106 | S753 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
Q9H6S1 | AZI2 | S318 | ochoa | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223). {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}. |
Q9H706 | GAREM1 | S759 | ochoa | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
Q9H9A7 | RMI1 | S292 | ochoa|psp | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}. |
Q9HAV0 | GNB4 | S136 | ochoa | Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4) | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
Q9HCJ3 | RAVER2 | S635 | ochoa | Ribonucleoprotein PTB-binding 2 (Protein raver-2) | May bind single-stranded nucleic acids. {ECO:0000305}. |
Q9HCM1 | RESF1 | S868 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
Q9NWH9 | SLTM | S374 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
Q9NXL9 | MCM9 | S942 | ochoa | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. |
Q9NXP7 | GIN1 | S494 | ochoa | Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain-containing protein) | None |
Q9NY27 | PPP4R2 | S388 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
Q9NYP3 | DONSON | S139 | ochoa | Protein downstream neighbor of Son (B17) | Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. {ECO:0000269|PubMed:28191891}. |
Q9NZN8 | CNOT2 | S61 | ochoa | CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. |
Q9P0V9 | SEPTIN10 | S434 | ochoa | Septin-10 | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}. |
Q9P243 | ZFAT | S21 | ochoa | Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) | May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}. |
Q9P2R6 | RERE | S679 | ochoa | Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein) | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
Q9UEG4 | ZNF629 | S52 | ochoa | Zinc finger protein 629 (Zinc finger protein 65) | May be involved in transcriptional regulation. |
Q9UHB6 | LIMA1 | S168 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
Q9UHB7 | AFF4 | S409 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
Q9UJF2 | RASAL2 | S1119 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
Q9UKJ3 | GPATCH8 | S491 | ochoa | G patch domain-containing protein 8 | None |
Q9UKJ3 | GPATCH8 | S653 | ochoa | G patch domain-containing protein 8 | None |
Q9UKK3 | PARP4 | S1306 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
Q9ULI3 | HEG1 | S426 | ochoa | Protein HEG homolog 1 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. {ECO:0000250}. |
Q9ULJ3 | ZBTB21 | S714 | ochoa | Zinc finger and BTB domain-containing protein 21 (Zinc finger protein 295) | Acts as a transcription repressor. {ECO:0000269|PubMed:15629158}. |
Q9UNQ0 | ABCG2 | S353 | ochoa | Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response. {ECO:0000250|UniProtKB:Q7TMS5, ECO:0000269|PubMed:11306452, ECO:0000269|PubMed:12477054, ECO:0000269|PubMed:12682043, ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:15670731, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:19506252, ECO:0000269|PubMed:20110355, ECO:0000269|PubMed:20368174, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181, ECO:0000269|PubMed:28554189, ECO:0000269|PubMed:30405239, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042, ECO:0000269|PubMed:38181789, ECO:0000305|PubMed:12958161}. |
Q9Y2D8 | SSX2IP | S587 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
Q9Y2J2 | EPB41L3 | S495 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
Q9Y6A5 | TACC3 | S25 | ochoa | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
Q9UL25 | RAB21 | S143 | Sugiyama | Ras-related protein Rab-21 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18804435, PubMed:25648148, PubMed:31455601). RAB21 is involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601). {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:31455601}. |
Q13114 | TRAF3 | S75 | PSP | TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) | Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types (PubMed:33148796, PubMed:33608556). In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome (PubMed:25847972, PubMed:27980081). Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance (PubMed:27438768). Also acts as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. {ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819, ECO:0000269|PubMed:25847972, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:32562145, ECO:0000269|PubMed:33148796, ECO:0000269|PubMed:33608556, ECO:0000269|PubMed:34011520}. |
Q27J81 | INF2 | S855 | Sugiyama | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
O00562 | PITPNM1 | S326 | Sugiyama | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) | Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.000135 | 3.870 |
R-HSA-428543 | Inactivation of CDC42 and RAC1 | 0.000135 | 3.870 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.000079 | 4.103 |
R-HSA-73894 | DNA Repair | 0.000061 | 4.217 |
R-HSA-8964315 | G beta:gamma signalling through BTK | 0.000514 | 3.289 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.001006 | 2.998 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.001130 | 2.947 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.001130 | 2.947 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.001130 | 2.947 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.001130 | 2.947 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 0.000805 | 3.094 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.000575 | 3.240 |
R-HSA-5693538 | Homology Directed Repair | 0.000731 | 3.136 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.002081 | 2.682 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.002460 | 2.609 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.002926 | 2.534 |
R-HSA-397795 | G-protein beta:gamma signalling | 0.003956 | 2.403 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.004543 | 2.343 |
R-HSA-5693537 | Resolution of D-Loop Structures | 0.004243 | 2.372 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.003956 | 2.403 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.003956 | 2.403 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.003264 | 2.486 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.004543 | 2.343 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.004469 | 2.350 |
R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 0.003637 | 2.439 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.004855 | 2.314 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.005277 | 2.278 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.005277 | 2.278 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.005869 | 2.231 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.006623 | 2.179 |
R-HSA-5467333 | APC truncation mutants are not K63 polyubiquitinated | 0.007979 | 2.098 |
R-HSA-9711123 | Cellular response to chemical stress | 0.008828 | 2.054 |
R-HSA-9675135 | Diseases of DNA repair | 0.009629 | 2.016 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.011131 | 1.953 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.010617 | 1.974 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.015895 | 1.799 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.015895 | 1.799 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 0.015895 | 1.799 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.015895 | 1.799 |
R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.015895 | 1.799 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.015895 | 1.799 |
R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.015895 | 1.799 |
R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.014937 | 1.826 |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.015136 | 1.820 |
R-HSA-6782135 | Dual incision in TC-NER | 0.016411 | 1.785 |
R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.012582 | 1.900 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.012008 | 1.921 |
R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.016180 | 1.791 |
R-HSA-500657 | Presynaptic function of Kainate receptors | 0.014937 | 1.826 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.017070 | 1.768 |
R-HSA-202040 | G-protein activation | 0.018794 | 1.726 |
R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.018794 | 1.726 |
R-HSA-9707616 | Heme signaling | 0.019136 | 1.718 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.023021 | 1.638 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.022873 | 1.641 |
R-HSA-5602571 | TRAF3 deficiency - HSE | 0.023748 | 1.624 |
R-HSA-429947 | Deadenylation of mRNA | 0.024509 | 1.611 |
R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.026036 | 1.584 |
R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.026036 | 1.584 |
R-HSA-1296059 | G protein gated Potassium channels | 0.026036 | 1.584 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.023820 | 1.623 |
R-HSA-428930 | Thromboxane signalling through TP receptor | 0.024509 | 1.611 |
R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.024509 | 1.611 |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.029619 | 1.528 |
R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.027600 | 1.559 |
R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.027600 | 1.559 |
R-HSA-9843745 | Adipogenesis | 0.031159 | 1.506 |
R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.030839 | 1.511 |
R-HSA-69481 | G2/M Checkpoints | 0.027957 | 1.554 |
R-HSA-2206291 | MPS IIIC - Sanfilippo syndrome C | 0.031540 | 1.501 |
R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.031540 | 1.501 |
R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.031540 | 1.501 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.037738 | 1.423 |
R-HSA-1296065 | Inwardly rectifying K+ channels | 0.037738 | 1.423 |
R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.034220 | 1.466 |
R-HSA-420092 | Glucagon-type ligand receptors | 0.032512 | 1.488 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.034220 | 1.466 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.037302 | 1.428 |
R-HSA-9008059 | Interleukin-37 signaling | 0.034220 | 1.466 |
R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.046937 | 1.328 |
R-HSA-5696400 | Dual Incision in GG-NER | 0.043261 | 1.364 |
R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.043261 | 1.364 |
R-HSA-392518 | Signal amplification | 0.043261 | 1.364 |
R-HSA-165181 | Inhibition of TSC complex formation by PKB | 0.046937 | 1.328 |
R-HSA-9960525 | CASP5-mediated substrate cleavage | 0.039269 | 1.406 |
R-HSA-205025 | NADE modulates death signalling | 0.046937 | 1.328 |
R-HSA-9960519 | CASP4-mediated substrate cleavage | 0.039269 | 1.406 |
R-HSA-9707587 | Regulation of HMOX1 expression and activity | 0.046937 | 1.328 |
R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.041388 | 1.383 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.043261 | 1.364 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.041489 | 1.382 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.042441 | 1.372 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.047100 | 1.327 |
R-HSA-74158 | RNA Polymerase III Transcription | 0.047100 | 1.327 |
R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.049064 | 1.309 |
R-HSA-5689896 | Ovarian tumor domain proteases | 0.049064 | 1.309 |
R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 0.054545 | 1.263 |
R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.054545 | 1.263 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.057210 | 1.243 |
R-HSA-991365 | Activation of GABAB receptors | 0.061448 | 1.211 |
R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 0.054545 | 1.263 |
R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.061448 | 1.211 |
R-HSA-977444 | GABA B receptor activation | 0.061448 | 1.211 |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.061448 | 1.211 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.055132 | 1.259 |
R-HSA-5260271 | Diseases of Immune System | 0.055132 | 1.259 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.059316 | 1.227 |
R-HSA-157579 | Telomere Maintenance | 0.056644 | 1.247 |
R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 0.054545 | 1.263 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.057210 | 1.243 |
R-HSA-165159 | MTOR signalling | 0.061448 | 1.211 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.053081 | 1.275 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.053081 | 1.275 |
R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 0.062092 | 1.207 |
R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.062092 | 1.207 |
R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 0.062092 | 1.207 |
R-HSA-194313 | VEGF ligand-receptor interactions | 0.062092 | 1.207 |
R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.084377 | 1.074 |
R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.084377 | 1.074 |
R-HSA-4839744 | Signaling by APC mutants | 0.106136 | 0.974 |
R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.106136 | 0.974 |
R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.106136 | 0.974 |
R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.106136 | 0.974 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.113275 | 0.946 |
R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.113275 | 0.946 |
R-HSA-5339716 | Signaling by GSK3beta mutants | 0.113275 | 0.946 |
R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.120357 | 0.920 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.120357 | 0.920 |
R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.120357 | 0.920 |
R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.120357 | 0.920 |
R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.120357 | 0.920 |
R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.120357 | 0.920 |
R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.141267 | 0.850 |
R-HSA-5656121 | Translesion synthesis by POLI | 0.148127 | 0.829 |
R-HSA-5655862 | Translesion synthesis by POLK | 0.154933 | 0.810 |
R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.168383 | 0.774 |
R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.188160 | 0.725 |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.070230 | 1.153 |
R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.194649 | 0.711 |
R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.194649 | 0.711 |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.207471 | 0.683 |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.207471 | 0.683 |
R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.084106 | 1.075 |
R-HSA-1989781 | PPARA activates gene expression | 0.162301 | 0.790 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.127382 | 0.895 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.166169 | 0.779 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 0.243925 | 0.613 |
R-HSA-5656169 | Termination of translesion DNA synthesis | 0.244736 | 0.611 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.188493 | 0.725 |
R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.113275 | 0.946 |
R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.154933 | 0.810 |
R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.213806 | 0.670 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.129845 | 0.887 |
R-HSA-72086 | mRNA Capping | 0.244736 | 0.611 |
R-HSA-5696398 | Nucleotide Excision Repair | 0.068465 | 1.165 |
R-HSA-110312 | Translesion synthesis by REV1 | 0.141267 | 0.850 |
R-HSA-69091 | Polymerase switching | 0.120357 | 0.920 |
R-HSA-69109 | Leading Strand Synthesis | 0.120357 | 0.920 |
R-HSA-110320 | Translesion Synthesis by POLH | 0.175028 | 0.757 |
R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.194649 | 0.711 |
R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.201085 | 0.697 |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.086495 | 1.063 |
R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.232512 | 0.634 |
R-HSA-4641265 | Repression of WNT target genes | 0.120357 | 0.920 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.091688 | 1.038 |
R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.250775 | 0.601 |
R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.168498 | 0.773 |
R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.201085 | 0.697 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.140669 | 0.852 |
R-HSA-4791275 | Signaling by WNT in cancer | 0.262711 | 0.581 |
R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.154933 | 0.810 |
R-HSA-75153 | Apoptotic execution phase | 0.070230 | 1.153 |
R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.077008 | 1.113 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.077008 | 1.113 |
R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.091688 | 1.038 |
R-HSA-4839748 | Signaling by AMER1 mutants | 0.113275 | 0.946 |
R-HSA-4839735 | Signaling by AXIN mutants | 0.113275 | 0.946 |
R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.168383 | 0.774 |
R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.168383 | 0.774 |
R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.220091 | 0.657 |
R-HSA-73864 | RNA Polymerase I Transcription | 0.151680 | 0.819 |
R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 0.127382 | 0.895 |
R-HSA-9634597 | GPER1 signaling | 0.074765 | 1.126 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.201085 | 0.697 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.101237 | 0.995 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.262711 | 0.581 |
R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.146153 | 0.835 |
R-HSA-390466 | Chaperonin-mediated protein folding | 0.179880 | 0.745 |
R-HSA-2424491 | DAP12 signaling | 0.250775 | 0.601 |
R-HSA-2161517 | Abacavir transmembrane transport | 0.069579 | 1.158 |
R-HSA-1483226 | Synthesis of PI | 0.106136 | 0.974 |
R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.188160 | 0.725 |
R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.213806 | 0.670 |
R-HSA-113418 | Formation of the Early Elongation Complex | 0.238648 | 0.622 |
R-HSA-418597 | G alpha (z) signalling events | 0.091332 | 1.039 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.232512 | 0.634 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.232512 | 0.634 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.250775 | 0.601 |
R-HSA-69186 | Lagging Strand Synthesis | 0.188160 | 0.725 |
R-HSA-425986 | Sodium/Proton exchangers | 0.084377 | 1.074 |
R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.098941 | 1.005 |
R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.161685 | 0.791 |
R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.067997 | 1.168 |
R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.226326 | 0.645 |
R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 0.232512 | 0.634 |
R-HSA-977443 | GABA receptor activation | 0.103758 | 0.984 |
R-HSA-391251 | Protein folding | 0.197161 | 0.705 |
R-HSA-73886 | Chromosome Maintenance | 0.095112 | 1.022 |
R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.226326 | 0.645 |
R-HSA-422356 | Regulation of insulin secretion | 0.217565 | 0.662 |
R-HSA-5620971 | Pyroptosis | 0.238648 | 0.622 |
R-HSA-195721 | Signaling by WNT | 0.251632 | 0.599 |
R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 0.113275 | 0.946 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.067997 | 1.168 |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.238648 | 0.622 |
R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.250775 | 0.601 |
R-HSA-69190 | DNA strand elongation | 0.262711 | 0.581 |
R-HSA-4086398 | Ca2+ pathway | 0.137945 | 0.860 |
R-HSA-180786 | Extension of Telomeres | 0.101237 | 0.995 |
R-HSA-9755088 | Ribavirin ADME | 0.194649 | 0.711 |
R-HSA-2160916 | Hyaluronan degradation | 0.220091 | 0.657 |
R-HSA-5689901 | Metalloprotease DUBs | 0.226326 | 0.645 |
R-HSA-1266695 | Interleukin-7 signaling | 0.220091 | 0.657 |
R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.256767 | 0.590 |
R-HSA-1296071 | Potassium Channels | 0.211714 | 0.674 |
R-HSA-111471 | Apoptotic factor-mediated response | 0.168383 | 0.774 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.250775 | 0.601 |
R-HSA-166208 | mTORC1-mediated signalling | 0.201085 | 0.697 |
R-HSA-2024096 | HS-GAG degradation | 0.262711 | 0.581 |
R-HSA-445717 | Aquaporin-mediated transport | 0.106296 | 0.973 |
R-HSA-9793528 | Ciprofloxacin ADME | 0.134352 | 0.872 |
R-HSA-9686114 | Non-canonical inflammasome activation | 0.134352 | 0.872 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.137945 | 0.860 |
R-HSA-9683610 | Maturation of nucleoprotein | 0.127382 | 0.895 |
R-HSA-2161522 | Abacavir ADME | 0.226326 | 0.645 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.157248 | 0.803 |
R-HSA-418346 | Platelet homeostasis | 0.244049 | 0.613 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.174173 | 0.759 |
R-HSA-2206281 | Mucopolysaccharidoses | 0.250775 | 0.601 |
R-HSA-9007101 | Rab regulation of trafficking | 0.088864 | 1.051 |
R-HSA-111885 | Opioid Signalling | 0.235199 | 0.629 |
R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.113275 | 0.946 |
R-HSA-418885 | DCC mediated attractive signaling | 0.141267 | 0.850 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.152756 | 0.816 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.147788 | 0.830 |
R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.232512 | 0.634 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.226369 | 0.645 |
R-HSA-1640170 | Cell Cycle | 0.131761 | 0.880 |
R-HSA-73884 | Base Excision Repair | 0.188493 | 0.725 |
R-HSA-9694631 | Maturation of nucleoprotein | 0.175028 | 0.757 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.201085 | 0.697 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.111423 | 0.953 |
R-HSA-196807 | Nicotinate metabolism | 0.121863 | 0.914 |
R-HSA-2028269 | Signaling by Hippo | 0.161685 | 0.791 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.201085 | 0.697 |
R-HSA-376176 | Signaling by ROBO receptors | 0.103919 | 0.983 |
R-HSA-4839726 | Chromatin organization | 0.170474 | 0.768 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.143405 | 0.843 |
R-HSA-449836 | Other interleukin signaling | 0.175028 | 0.757 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 0.235199 | 0.629 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.154459 | 0.811 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.184642 | 0.734 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.160378 | 0.795 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.188493 | 0.725 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.220496 | 0.657 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.160047 | 0.796 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.172022 | 0.764 |
R-HSA-72172 | mRNA Splicing | 0.267501 | 0.573 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.267702 | 0.572 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.274458 | 0.562 |
R-HSA-189483 | Heme degradation | 0.274458 | 0.562 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.280261 | 0.552 |
R-HSA-2142845 | Hyaluronan metabolism | 0.280261 | 0.552 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.282491 | 0.549 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.286019 | 0.544 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.290479 | 0.537 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.291731 | 0.535 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.295847 | 0.529 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.297397 | 0.527 |
R-HSA-196757 | Metabolism of folate and pterines | 0.297397 | 0.527 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.300205 | 0.523 |
R-HSA-422475 | Axon guidance | 0.301459 | 0.521 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.308595 | 0.511 |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.308595 | 0.511 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.314128 | 0.503 |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.314128 | 0.503 |
R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 0.314128 | 0.503 |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.314128 | 0.503 |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.314128 | 0.503 |
R-HSA-167169 | HIV Transcription Elongation | 0.314128 | 0.503 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.314128 | 0.503 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.314128 | 0.503 |
R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.319617 | 0.495 |
R-HSA-3214841 | PKMTs methylate histone lysines | 0.319617 | 0.495 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.324063 | 0.489 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.325062 | 0.488 |
R-HSA-167161 | HIV Transcription Initiation | 0.325062 | 0.488 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.325062 | 0.488 |
R-HSA-189451 | Heme biosynthesis | 0.325062 | 0.488 |
R-HSA-9683701 | Translation of Structural Proteins | 0.325062 | 0.488 |
R-HSA-9909396 | Circadian clock | 0.332477 | 0.478 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.335822 | 0.474 |
R-HSA-8854214 | TBC/RABGAPs | 0.335822 | 0.474 |
R-HSA-2172127 | DAP12 interactions | 0.341139 | 0.467 |
R-HSA-3928662 | EPHB-mediated forward signaling | 0.341139 | 0.467 |
R-HSA-373752 | Netrin-1 signaling | 0.341139 | 0.467 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.346413 | 0.460 |
R-HSA-6783310 | Fanconi Anemia Pathway | 0.346413 | 0.460 |
R-HSA-163685 | Integration of energy metabolism | 0.347017 | 0.460 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.347017 | 0.460 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.351645 | 0.454 |
R-HSA-9675108 | Nervous system development | 0.353749 | 0.451 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.356836 | 0.448 |
R-HSA-425410 | Metal ion SLC transporters | 0.361985 | 0.441 |
R-HSA-73893 | DNA Damage Bypass | 0.367094 | 0.435 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.367094 | 0.435 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.372162 | 0.429 |
R-HSA-9748787 | Azathioprine ADME | 0.372162 | 0.429 |
R-HSA-912446 | Meiotic recombination | 0.377189 | 0.423 |
R-HSA-5688426 | Deubiquitination | 0.378557 | 0.422 |
R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.382177 | 0.418 |
R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.382177 | 0.418 |
R-HSA-6794361 | Neurexins and neuroligins | 0.382177 | 0.418 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.382177 | 0.418 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.384303 | 0.415 |
R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.387125 | 0.412 |
R-HSA-1221632 | Meiotic synapsis | 0.387125 | 0.412 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.389962 | 0.409 |
R-HSA-72649 | Translation initiation complex formation | 0.392034 | 0.407 |
R-HSA-446652 | Interleukin-1 family signaling | 0.395598 | 0.403 |
R-HSA-3214815 | HDACs deacetylate histones | 0.396904 | 0.401 |
R-HSA-9753281 | Paracetamol ADME | 0.396904 | 0.401 |
R-HSA-9012852 | Signaling by NOTCH3 | 0.396904 | 0.401 |
R-HSA-416476 | G alpha (q) signalling events | 0.397996 | 0.400 |
R-HSA-73887 | Death Receptor Signaling | 0.401211 | 0.397 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.401735 | 0.396 |
R-HSA-193648 | NRAGE signals death through JNK | 0.401735 | 0.396 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.401735 | 0.396 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.401735 | 0.396 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.406527 | 0.391 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.411282 | 0.386 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.411282 | 0.386 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.415999 | 0.381 |
R-HSA-191859 | snRNP Assembly | 0.415999 | 0.381 |
R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 0.415999 | 0.381 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.419406 | 0.377 |
R-HSA-8873719 | RAB geranylgeranylation | 0.420678 | 0.376 |
R-HSA-983189 | Kinesins | 0.420678 | 0.376 |
R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.420678 | 0.376 |
R-HSA-1227986 | Signaling by ERBB2 | 0.420678 | 0.376 |
R-HSA-109581 | Apoptosis | 0.423414 | 0.373 |
R-HSA-74160 | Gene expression (Transcription) | 0.427720 | 0.369 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.430021 | 0.367 |
R-HSA-9658195 | Leishmania infection | 0.434248 | 0.362 |
R-HSA-9824443 | Parasitic Infection Pathways | 0.434248 | 0.362 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.434494 | 0.362 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.434494 | 0.362 |
R-HSA-8854518 | AURKA Activation by TPX2 | 0.447982 | 0.349 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.447982 | 0.349 |
R-HSA-418555 | G alpha (s) signalling events | 0.450565 | 0.346 |
R-HSA-9664433 | Leishmania parasite growth and survival | 0.455910 | 0.341 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.455910 | 0.341 |
R-HSA-167172 | Transcription of the HIV genome | 0.456797 | 0.340 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.456797 | 0.340 |
R-HSA-5218859 | Regulated Necrosis | 0.456797 | 0.340 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.461225 | 0.336 |
R-HSA-9678108 | SARS-CoV-1 Infection | 0.461225 | 0.336 |
R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.465472 | 0.332 |
R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.469758 | 0.328 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.469758 | 0.328 |
R-HSA-189445 | Metabolism of porphyrins | 0.469758 | 0.328 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.474009 | 0.324 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.478227 | 0.320 |
R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.478227 | 0.320 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.482182 | 0.317 |
R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.482411 | 0.317 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.482411 | 0.317 |
R-HSA-380287 | Centrosome maturation | 0.486562 | 0.313 |
R-HSA-8852135 | Protein ubiquitination | 0.486562 | 0.313 |
R-HSA-917937 | Iron uptake and transport | 0.486562 | 0.313 |
R-HSA-1980143 | Signaling by NOTCH1 | 0.490680 | 0.309 |
R-HSA-9679506 | SARS-CoV Infections | 0.491537 | 0.308 |
R-HSA-9694635 | Translation of Structural Proteins | 0.494765 | 0.306 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.498818 | 0.302 |
R-HSA-5617833 | Cilium Assembly | 0.500108 | 0.301 |
R-HSA-168898 | Toll-like Receptor Cascades | 0.502637 | 0.299 |
R-HSA-9659379 | Sensory processing of sound | 0.502839 | 0.299 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.506827 | 0.295 |
R-HSA-9833482 | PKR-mediated signaling | 0.506827 | 0.295 |
R-HSA-1630316 | Glycosaminoglycan metabolism | 0.507670 | 0.294 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.518603 | 0.285 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.519947 | 0.284 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.522466 | 0.282 |
R-HSA-1500620 | Meiosis | 0.526298 | 0.279 |
R-HSA-6794362 | Protein-protein interactions at synapses | 0.526298 | 0.279 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.526298 | 0.279 |
R-HSA-8953854 | Metabolism of RNA | 0.532391 | 0.274 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.533871 | 0.273 |
R-HSA-5357801 | Programmed Cell Death | 0.539573 | 0.268 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.541323 | 0.267 |
R-HSA-1236974 | ER-Phagosome pathway | 0.545005 | 0.264 |
R-HSA-112310 | Neurotransmitter release cycle | 0.548658 | 0.261 |
R-HSA-112316 | Neuronal System | 0.553040 | 0.257 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.555876 | 0.255 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.556157 | 0.255 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.558492 | 0.253 |
R-HSA-2682334 | EPH-Ephrin signaling | 0.559442 | 0.252 |
R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.559442 | 0.252 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 0.562980 | 0.250 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.566489 | 0.247 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.569971 | 0.244 |
R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.569971 | 0.244 |
R-HSA-9748784 | Drug ADME | 0.570036 | 0.244 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.576851 | 0.239 |
R-HSA-8951664 | Neddylation | 0.576859 | 0.239 |
R-HSA-3214847 | HATs acetylate histones | 0.586966 | 0.231 |
R-HSA-8953897 | Cellular responses to stimuli | 0.594719 | 0.226 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 0.596499 | 0.224 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.596842 | 0.224 |
R-HSA-9833110 | RSV-host interactions | 0.606483 | 0.217 |
R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.609646 | 0.215 |
R-HSA-8939211 | ESR-mediated signaling | 0.611915 | 0.213 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 0.612783 | 0.213 |
R-HSA-69239 | Synthesis of DNA | 0.615895 | 0.210 |
R-HSA-157118 | Signaling by NOTCH | 0.618239 | 0.209 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.618983 | 0.208 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.618983 | 0.208 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.618983 | 0.208 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.618983 | 0.208 |
R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.625084 | 0.204 |
R-HSA-166166 | MyD88-independent TLR4 cascade | 0.625084 | 0.204 |
R-HSA-68886 | M Phase | 0.629208 | 0.201 |
R-HSA-913531 | Interferon Signaling | 0.630879 | 0.200 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.631089 | 0.200 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.631089 | 0.200 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.642813 | 0.192 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 0.645686 | 0.190 |
R-HSA-72737 | Cap-dependent Translation Initiation | 0.648536 | 0.188 |
R-HSA-72613 | Eukaryotic Translation Initiation | 0.648536 | 0.188 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.656436 | 0.183 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.656950 | 0.182 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.656950 | 0.182 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.665164 | 0.177 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.665164 | 0.177 |
R-HSA-2132295 | MHC class II antigen presentation | 0.667858 | 0.175 |
R-HSA-194138 | Signaling by VEGF | 0.675813 | 0.170 |
R-HSA-114608 | Platelet degranulation | 0.681011 | 0.167 |
R-HSA-1474165 | Reproduction | 0.691159 | 0.160 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.695667 | 0.158 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.696113 | 0.157 |
R-HSA-1474228 | Degradation of the extracellular matrix | 0.696113 | 0.157 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.698560 | 0.156 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.710506 | 0.148 |
R-HSA-9664417 | Leishmania phagocytosis | 0.717446 | 0.144 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.717446 | 0.144 |
R-HSA-9664407 | Parasite infection | 0.717446 | 0.144 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.719723 | 0.143 |
R-HSA-1632852 | Macroautophagy | 0.719723 | 0.143 |
R-HSA-1266738 | Developmental Biology | 0.721418 | 0.142 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.724222 | 0.140 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.724222 | 0.140 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.731108 | 0.136 |
R-HSA-2262752 | Cellular responses to stress | 0.733199 | 0.135 |
R-HSA-69242 | S Phase | 0.737293 | 0.132 |
R-HSA-166520 | Signaling by NTRKs | 0.737293 | 0.132 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.745664 | 0.127 |
R-HSA-69306 | DNA Replication | 0.747715 | 0.126 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.749749 | 0.125 |
R-HSA-9612973 | Autophagy | 0.753770 | 0.123 |
R-HSA-162587 | HIV Life Cycle | 0.755756 | 0.122 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.757726 | 0.120 |
R-HSA-449147 | Signaling by Interleukins | 0.764496 | 0.117 |
R-HSA-8957322 | Metabolism of steroids | 0.764593 | 0.117 |
R-HSA-109582 | Hemostasis | 0.777685 | 0.109 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.785455 | 0.105 |
R-HSA-199991 | Membrane Trafficking | 0.787861 | 0.104 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.788906 | 0.103 |
R-HSA-5683057 | MAPK family signaling cascades | 0.795174 | 0.100 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.797662 | 0.098 |
R-HSA-69275 | G2/M Transition | 0.808484 | 0.092 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.811567 | 0.091 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.814344 | 0.089 |
R-HSA-68877 | Mitotic Prometaphase | 0.819061 | 0.087 |
R-HSA-212436 | Generic Transcription Pathway | 0.819865 | 0.086 |
R-HSA-9824446 | Viral Infection Pathways | 0.820540 | 0.086 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.829058 | 0.081 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.829058 | 0.081 |
R-HSA-428157 | Sphingolipid metabolism | 0.830441 | 0.081 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.833173 | 0.079 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.833173 | 0.079 |
R-HSA-425407 | SLC-mediated transmembrane transport | 0.850825 | 0.070 |
R-HSA-418594 | G alpha (i) signalling events | 0.859991 | 0.066 |
R-HSA-162906 | HIV Infection | 0.863855 | 0.064 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.864958 | 0.063 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.866052 | 0.062 |
R-HSA-388396 | GPCR downstream signalling | 0.884999 | 0.053 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.886748 | 0.052 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.892491 | 0.049 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.897253 | 0.047 |
R-HSA-9734767 | Developmental Cell Lineages | 0.898455 | 0.047 |
R-HSA-5653656 | Vesicle-mediated transport | 0.903526 | 0.044 |
R-HSA-382551 | Transport of small molecules | 0.909056 | 0.041 |
R-HSA-162582 | Signal Transduction | 0.911989 | 0.040 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.917869 | 0.037 |
R-HSA-1483257 | Phospholipid metabolism | 0.921797 | 0.035 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.922434 | 0.035 |
R-HSA-372790 | Signaling by GPCR | 0.925624 | 0.034 |
R-HSA-597592 | Post-translational protein modification | 0.930446 | 0.031 |
R-HSA-5663205 | Infectious disease | 0.939245 | 0.027 |
R-HSA-1474244 | Extracellular matrix organization | 0.941746 | 0.026 |
R-HSA-500792 | GPCR ligand binding | 0.958280 | 0.019 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.962285 | 0.017 |
R-HSA-392499 | Metabolism of proteins | 0.962681 | 0.017 |
R-HSA-8978868 | Fatty acid metabolism | 0.969040 | 0.014 |
R-HSA-5668914 | Diseases of metabolism | 0.973741 | 0.012 |
R-HSA-72766 | Translation | 0.974171 | 0.011 |
R-HSA-1280218 | Adaptive Immune System | 0.974523 | 0.011 |
R-HSA-1643685 | Disease | 0.977907 | 0.010 |
R-HSA-6798695 | Neutrophil degranulation | 0.979497 | 0.009 |
R-HSA-556833 | Metabolism of lipids | 0.984636 | 0.007 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.987310 | 0.006 |
R-HSA-168256 | Immune System | 0.992591 | 0.003 |
R-HSA-168249 | Innate Immune System | 0.995652 | 0.002 |
R-HSA-1430728 | Metabolism | 0.999970 | 0.000 |
R-HSA-9709957 | Sensory Perception | 0.999972 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
JNK2 |
0.875 | 0.758 | 1 | 0.940 |
CDK8 |
0.873 | 0.652 | 1 | 0.945 |
JNK3 |
0.872 | 0.742 | 1 | 0.948 |
KIS |
0.871 | 0.586 | 1 | 0.951 |
NLK |
0.871 | 0.613 | 1 | 0.895 |
CLK3 |
0.870 | 0.438 | 1 | 0.852 |
DYRK2 |
0.869 | 0.632 | 1 | 0.946 |
CDK19 |
0.868 | 0.641 | 1 | 0.936 |
P38G |
0.868 | 0.723 | 1 | 0.909 |
CDK18 |
0.867 | 0.673 | 1 | 0.924 |
COT |
0.866 | 0.042 | 2 | 0.879 |
CDK7 |
0.866 | 0.639 | 1 | 0.950 |
CDK17 |
0.865 | 0.689 | 1 | 0.907 |
CDK1 |
0.863 | 0.659 | 1 | 0.935 |
CDK13 |
0.863 | 0.646 | 1 | 0.945 |
P38B |
0.862 | 0.685 | 1 | 0.916 |
CDK16 |
0.862 | 0.687 | 1 | 0.910 |
CDK5 |
0.861 | 0.635 | 1 | 0.939 |
ERK5 |
0.861 | 0.347 | 1 | 0.793 |
SRPK1 |
0.861 | 0.312 | -3 | 0.775 |
ERK1 |
0.861 | 0.666 | 1 | 0.924 |
P38D |
0.860 | 0.711 | 1 | 0.912 |
HIPK2 |
0.860 | 0.620 | 1 | 0.942 |
ERK2 |
0.859 | 0.676 | 1 | 0.933 |
MTOR |
0.859 | 0.167 | 1 | 0.746 |
HIPK4 |
0.858 | 0.365 | 1 | 0.885 |
DYRK4 |
0.857 | 0.641 | 1 | 0.948 |
P38A |
0.857 | 0.650 | 1 | 0.928 |
CDK12 |
0.856 | 0.643 | 1 | 0.942 |
CDK3 |
0.856 | 0.608 | 1 | 0.913 |
CDK14 |
0.856 | 0.662 | 1 | 0.932 |
CDK9 |
0.854 | 0.629 | 1 | 0.945 |
HIPK1 |
0.853 | 0.569 | 1 | 0.946 |
DYRK1B |
0.853 | 0.609 | 1 | 0.936 |
CDK2 |
0.852 | 0.512 | 1 | 0.913 |
PIM3 |
0.852 | 0.039 | -3 | 0.855 |
CDKL1 |
0.852 | 0.146 | -3 | 0.834 |
SRPK2 |
0.851 | 0.256 | -3 | 0.701 |
CDC7 |
0.851 | -0.075 | 1 | 0.638 |
PRPK |
0.850 | -0.097 | -1 | 0.857 |
ICK |
0.850 | 0.298 | -3 | 0.862 |
CDK10 |
0.849 | 0.625 | 1 | 0.934 |
DYRK1A |
0.849 | 0.502 | 1 | 0.947 |
DSTYK |
0.849 | -0.049 | 2 | 0.876 |
IKKB |
0.849 | -0.088 | -2 | 0.765 |
CLK4 |
0.848 | 0.339 | -3 | 0.784 |
CDKL5 |
0.848 | 0.151 | -3 | 0.827 |
NDR2 |
0.848 | 0.011 | -3 | 0.853 |
RAF1 |
0.848 | -0.127 | 1 | 0.650 |
JNK1 |
0.847 | 0.649 | 1 | 0.927 |
PKN3 |
0.847 | 0.022 | -3 | 0.854 |
CLK1 |
0.847 | 0.360 | -3 | 0.753 |
CAMK1B |
0.847 | 0.011 | -3 | 0.883 |
ULK2 |
0.847 | -0.134 | 2 | 0.785 |
TBK1 |
0.846 | -0.136 | 1 | 0.578 |
PDHK4 |
0.845 | -0.180 | 1 | 0.702 |
NUAK2 |
0.845 | 0.049 | -3 | 0.854 |
CAMK2G |
0.845 | -0.038 | 2 | 0.799 |
GCN2 |
0.844 | -0.203 | 2 | 0.790 |
MOS |
0.844 | -0.055 | 1 | 0.691 |
HIPK3 |
0.844 | 0.537 | 1 | 0.930 |
PIM1 |
0.844 | 0.090 | -3 | 0.802 |
WNK1 |
0.844 | -0.017 | -2 | 0.874 |
DYRK3 |
0.844 | 0.469 | 1 | 0.933 |
BMPR2 |
0.844 | -0.152 | -2 | 0.879 |
CLK2 |
0.843 | 0.378 | -3 | 0.763 |
PKCD |
0.843 | 0.038 | 2 | 0.791 |
RSK2 |
0.842 | 0.050 | -3 | 0.784 |
IKKE |
0.842 | -0.147 | 1 | 0.572 |
NDR1 |
0.842 | -0.006 | -3 | 0.850 |
RIPK3 |
0.841 | -0.092 | 3 | 0.728 |
CDK4 |
0.841 | 0.647 | 1 | 0.935 |
PRKD1 |
0.841 | 0.008 | -3 | 0.834 |
ATR |
0.841 | -0.064 | 1 | 0.659 |
CDK6 |
0.841 | 0.625 | 1 | 0.929 |
IKKA |
0.841 | -0.018 | -2 | 0.753 |
NIK |
0.841 | -0.027 | -3 | 0.898 |
PKN2 |
0.840 | -0.008 | -3 | 0.858 |
NEK6 |
0.840 | -0.074 | -2 | 0.853 |
SRPK3 |
0.840 | 0.206 | -3 | 0.756 |
P90RSK |
0.840 | 0.035 | -3 | 0.795 |
NEK7 |
0.840 | -0.142 | -3 | 0.863 |
MST4 |
0.840 | -0.027 | 2 | 0.837 |
HUNK |
0.839 | -0.079 | 2 | 0.810 |
CAMLCK |
0.839 | 0.007 | -2 | 0.851 |
PDHK1 |
0.839 | -0.192 | 1 | 0.680 |
MAPKAPK3 |
0.839 | 0.008 | -3 | 0.793 |
TGFBR2 |
0.839 | -0.079 | -2 | 0.784 |
LATS2 |
0.838 | 0.008 | -5 | 0.828 |
MARK4 |
0.838 | -0.034 | 4 | 0.793 |
ULK1 |
0.838 | -0.143 | -3 | 0.845 |
AMPKA1 |
0.838 | -0.015 | -3 | 0.867 |
MLK1 |
0.838 | -0.116 | 2 | 0.811 |
PRKD2 |
0.837 | 0.025 | -3 | 0.767 |
SKMLCK |
0.837 | -0.028 | -2 | 0.855 |
GRK6 |
0.837 | 0.003 | 1 | 0.641 |
GRK5 |
0.837 | -0.099 | -3 | 0.894 |
PRP4 |
0.837 | 0.376 | -3 | 0.785 |
MAPKAPK2 |
0.837 | 0.045 | -3 | 0.744 |
TSSK2 |
0.836 | -0.007 | -5 | 0.858 |
WNK3 |
0.835 | -0.174 | 1 | 0.644 |
P70S6KB |
0.835 | 0.017 | -3 | 0.816 |
RSK3 |
0.835 | 0.008 | -3 | 0.784 |
CAMK2D |
0.834 | -0.052 | -3 | 0.861 |
IRE1 |
0.834 | -0.057 | 1 | 0.639 |
TSSK1 |
0.833 | -0.011 | -3 | 0.878 |
DAPK2 |
0.833 | -0.049 | -3 | 0.889 |
RIPK1 |
0.833 | -0.150 | 1 | 0.655 |
FAM20C |
0.832 | 0.051 | 2 | 0.628 |
NEK9 |
0.832 | -0.161 | 2 | 0.821 |
DLK |
0.832 | -0.133 | 1 | 0.664 |
AMPKA2 |
0.832 | -0.013 | -3 | 0.833 |
CHAK2 |
0.832 | -0.093 | -1 | 0.851 |
BCKDK |
0.832 | -0.158 | -1 | 0.810 |
NUAK1 |
0.832 | -0.004 | -3 | 0.804 |
PKACG |
0.831 | -0.014 | -2 | 0.731 |
NIM1 |
0.831 | -0.071 | 3 | 0.769 |
CAMK2B |
0.830 | 0.015 | 2 | 0.775 |
PLK1 |
0.830 | -0.050 | -2 | 0.812 |
BMPR1B |
0.830 | 0.031 | 1 | 0.593 |
GRK1 |
0.829 | -0.023 | -2 | 0.767 |
IRE2 |
0.829 | -0.051 | 2 | 0.759 |
MLK2 |
0.829 | -0.131 | 2 | 0.810 |
MLK3 |
0.829 | -0.038 | 2 | 0.736 |
MELK |
0.829 | -0.028 | -3 | 0.818 |
ANKRD3 |
0.829 | -0.156 | 1 | 0.677 |
TGFBR1 |
0.828 | 0.006 | -2 | 0.801 |
PKCB |
0.828 | 0.002 | 2 | 0.736 |
CAMK4 |
0.828 | -0.085 | -3 | 0.837 |
ATM |
0.828 | -0.070 | 1 | 0.596 |
ALK4 |
0.828 | -0.018 | -2 | 0.824 |
PAK1 |
0.827 | -0.026 | -2 | 0.791 |
MSK2 |
0.827 | -0.013 | -3 | 0.773 |
ERK7 |
0.827 | 0.230 | 2 | 0.550 |
PKR |
0.827 | -0.041 | 1 | 0.671 |
PKCA |
0.827 | -0.003 | 2 | 0.726 |
AURC |
0.827 | 0.015 | -2 | 0.648 |
GRK4 |
0.827 | -0.122 | -2 | 0.807 |
CAMK2A |
0.827 | 0.018 | 2 | 0.790 |
PAK3 |
0.827 | -0.057 | -2 | 0.794 |
MASTL |
0.826 | -0.247 | -2 | 0.812 |
PRKD3 |
0.826 | 0.012 | -3 | 0.751 |
RSK4 |
0.826 | 0.044 | -3 | 0.755 |
PKCG |
0.826 | -0.018 | 2 | 0.730 |
LATS1 |
0.826 | 0.015 | -3 | 0.860 |
GRK7 |
0.825 | 0.059 | 1 | 0.615 |
QSK |
0.824 | -0.028 | 4 | 0.778 |
MNK2 |
0.824 | -0.036 | -2 | 0.792 |
QIK |
0.824 | -0.089 | -3 | 0.857 |
MAK |
0.824 | 0.409 | -2 | 0.736 |
MLK4 |
0.824 | -0.073 | 2 | 0.731 |
PHKG1 |
0.824 | -0.059 | -3 | 0.835 |
DNAPK |
0.824 | -0.020 | 1 | 0.566 |
TTBK2 |
0.824 | -0.188 | 2 | 0.669 |
PKCH |
0.824 | -0.030 | 2 | 0.722 |
VRK2 |
0.823 | -0.039 | 1 | 0.740 |
PLK3 |
0.822 | -0.046 | 2 | 0.761 |
SIK |
0.822 | -0.024 | -3 | 0.775 |
CHK1 |
0.822 | -0.013 | -3 | 0.844 |
MSK1 |
0.822 | 0.010 | -3 | 0.782 |
PKACB |
0.822 | 0.038 | -2 | 0.673 |
MEK1 |
0.821 | -0.131 | 2 | 0.840 |
MOK |
0.821 | 0.395 | 1 | 0.878 |
MYLK4 |
0.821 | -0.011 | -2 | 0.775 |
MARK3 |
0.821 | -0.013 | 4 | 0.736 |
MARK2 |
0.821 | -0.026 | 4 | 0.697 |
NEK2 |
0.821 | -0.121 | 2 | 0.792 |
PIM2 |
0.821 | 0.056 | -3 | 0.768 |
PINK1 |
0.821 | 0.091 | 1 | 0.788 |
SGK3 |
0.821 | 0.023 | -3 | 0.790 |
ALK2 |
0.820 | -0.018 | -2 | 0.809 |
YSK4 |
0.820 | -0.161 | 1 | 0.609 |
AURB |
0.820 | -0.007 | -2 | 0.649 |
PKCZ |
0.820 | -0.052 | 2 | 0.772 |
AKT2 |
0.820 | 0.049 | -3 | 0.705 |
PAK2 |
0.820 | -0.062 | -2 | 0.774 |
PKG2 |
0.819 | -0.001 | -2 | 0.666 |
BRAF |
0.818 | -0.057 | -4 | 0.861 |
PAK6 |
0.818 | -0.024 | -2 | 0.713 |
GSK3A |
0.818 | 0.163 | 4 | 0.441 |
ACVR2A |
0.818 | -0.056 | -2 | 0.777 |
MNK1 |
0.818 | -0.038 | -2 | 0.797 |
BRSK1 |
0.818 | -0.060 | -3 | 0.805 |
TLK2 |
0.817 | -0.113 | 1 | 0.622 |
PRKX |
0.817 | 0.057 | -3 | 0.690 |
DRAK1 |
0.816 | -0.085 | 1 | 0.596 |
ACVR2B |
0.816 | -0.070 | -2 | 0.794 |
MAPKAPK5 |
0.816 | -0.072 | -3 | 0.755 |
BRSK2 |
0.815 | -0.104 | -3 | 0.830 |
SMG1 |
0.815 | -0.116 | 1 | 0.615 |
PKCT |
0.815 | -0.022 | 2 | 0.732 |
CAMK1G |
0.815 | -0.027 | -3 | 0.777 |
PLK4 |
0.815 | -0.116 | 2 | 0.621 |
MARK1 |
0.815 | -0.054 | 4 | 0.752 |
IRAK4 |
0.815 | -0.086 | 1 | 0.627 |
WNK4 |
0.815 | -0.102 | -2 | 0.865 |
ZAK |
0.814 | -0.121 | 1 | 0.634 |
CHAK1 |
0.814 | -0.172 | 2 | 0.741 |
BMPR1A |
0.814 | 0.009 | 1 | 0.575 |
MEKK3 |
0.812 | -0.154 | 1 | 0.643 |
HRI |
0.812 | -0.189 | -2 | 0.840 |
AKT1 |
0.812 | 0.034 | -3 | 0.720 |
GRK2 |
0.811 | -0.079 | -2 | 0.703 |
DCAMKL1 |
0.811 | -0.042 | -3 | 0.783 |
AURA |
0.811 | -0.025 | -2 | 0.619 |
PERK |
0.811 | -0.170 | -2 | 0.821 |
MEKK1 |
0.810 | -0.183 | 1 | 0.650 |
SSTK |
0.810 | -0.043 | 4 | 0.758 |
MEK5 |
0.810 | -0.208 | 2 | 0.822 |
MEKK2 |
0.810 | -0.122 | 2 | 0.801 |
SNRK |
0.810 | -0.194 | 2 | 0.671 |
MST3 |
0.810 | -0.051 | 2 | 0.821 |
SMMLCK |
0.809 | -0.025 | -3 | 0.843 |
NEK5 |
0.809 | -0.146 | 1 | 0.643 |
MPSK1 |
0.809 | -0.010 | 1 | 0.665 |
GSK3B |
0.809 | 0.024 | 4 | 0.434 |
P70S6K |
0.808 | -0.015 | -3 | 0.737 |
PKCI |
0.808 | -0.019 | 2 | 0.747 |
PASK |
0.808 | -0.014 | -3 | 0.873 |
PHKG2 |
0.806 | -0.081 | -3 | 0.801 |
IRAK1 |
0.806 | -0.176 | -1 | 0.794 |
CAMKK1 |
0.806 | -0.107 | -2 | 0.798 |
GAK |
0.806 | -0.007 | 1 | 0.661 |
DCAMKL2 |
0.806 | -0.064 | -3 | 0.807 |
TLK1 |
0.805 | -0.166 | -2 | 0.824 |
CAMK1D |
0.805 | -0.006 | -3 | 0.700 |
PKACA |
0.805 | 0.013 | -2 | 0.616 |
TAO3 |
0.804 | -0.087 | 1 | 0.653 |
CK2A2 |
0.804 | 0.077 | 1 | 0.519 |
PKCE |
0.803 | 0.011 | 2 | 0.715 |
NEK8 |
0.803 | -0.147 | 2 | 0.806 |
CK1E |
0.803 | -0.037 | -3 | 0.584 |
LKB1 |
0.802 | -0.046 | -3 | 0.857 |
PKN1 |
0.802 | -0.007 | -3 | 0.744 |
TTBK1 |
0.801 | -0.167 | 2 | 0.591 |
CAMKK2 |
0.800 | -0.104 | -2 | 0.785 |
NEK11 |
0.800 | -0.172 | 1 | 0.654 |
PAK5 |
0.800 | -0.049 | -2 | 0.644 |
AKT3 |
0.799 | 0.046 | -3 | 0.640 |
TAO2 |
0.799 | -0.111 | 2 | 0.832 |
PDK1 |
0.799 | -0.085 | 1 | 0.670 |
SGK1 |
0.799 | 0.057 | -3 | 0.633 |
TAK1 |
0.798 | -0.110 | 1 | 0.642 |
CK1D |
0.797 | -0.012 | -3 | 0.536 |
NEK4 |
0.797 | -0.157 | 1 | 0.615 |
GRK3 |
0.796 | -0.075 | -2 | 0.655 |
HGK |
0.796 | -0.098 | 3 | 0.816 |
SBK |
0.795 | 0.111 | -3 | 0.575 |
CK1G1 |
0.795 | -0.073 | -3 | 0.574 |
MEKK6 |
0.795 | -0.127 | 1 | 0.630 |
CHK2 |
0.795 | -0.002 | -3 | 0.644 |
DAPK3 |
0.795 | -0.035 | -3 | 0.810 |
PAK4 |
0.794 | -0.050 | -2 | 0.646 |
MST2 |
0.794 | -0.149 | 1 | 0.622 |
MRCKB |
0.794 | 0.017 | -3 | 0.757 |
MRCKA |
0.794 | 0.016 | -3 | 0.772 |
VRK1 |
0.794 | -0.134 | 2 | 0.848 |
EEF2K |
0.794 | -0.093 | 3 | 0.805 |
GCK |
0.794 | -0.116 | 1 | 0.631 |
MINK |
0.793 | -0.132 | 1 | 0.616 |
TNIK |
0.793 | -0.076 | 3 | 0.812 |
PLK2 |
0.793 | -0.041 | -3 | 0.816 |
CK2A1 |
0.793 | 0.056 | 1 | 0.502 |
ROCK2 |
0.793 | 0.018 | -3 | 0.809 |
LRRK2 |
0.792 | -0.105 | 2 | 0.827 |
MAP3K15 |
0.792 | -0.153 | 1 | 0.630 |
CAMK1A |
0.792 | -0.004 | -3 | 0.658 |
CK1A2 |
0.792 | -0.035 | -3 | 0.534 |
NEK1 |
0.792 | -0.146 | 1 | 0.625 |
LOK |
0.792 | -0.097 | -2 | 0.760 |
RIPK2 |
0.790 | -0.215 | 1 | 0.603 |
HPK1 |
0.790 | -0.106 | 1 | 0.623 |
PDHK3_TYR |
0.788 | 0.156 | 4 | 0.854 |
DAPK1 |
0.788 | -0.040 | -3 | 0.801 |
DMPK1 |
0.787 | 0.054 | -3 | 0.760 |
YSK1 |
0.787 | -0.115 | 2 | 0.793 |
BUB1 |
0.787 | 0.003 | -5 | 0.819 |
MST1 |
0.786 | -0.159 | 1 | 0.610 |
STK33 |
0.786 | -0.158 | 2 | 0.596 |
PBK |
0.786 | -0.061 | 1 | 0.587 |
KHS2 |
0.786 | -0.053 | 1 | 0.629 |
KHS1 |
0.786 | -0.094 | 1 | 0.615 |
NEK3 |
0.785 | -0.134 | 1 | 0.622 |
SLK |
0.784 | -0.116 | -2 | 0.692 |
HASPIN |
0.784 | -0.000 | -1 | 0.706 |
MEK2 |
0.783 | -0.234 | 2 | 0.802 |
PKG1 |
0.782 | -0.031 | -2 | 0.587 |
TESK1_TYR |
0.780 | -0.008 | 3 | 0.855 |
ROCK1 |
0.780 | 0.002 | -3 | 0.772 |
TTK |
0.779 | -0.078 | -2 | 0.814 |
PDHK4_TYR |
0.779 | 0.049 | 2 | 0.875 |
OSR1 |
0.779 | -0.087 | 2 | 0.804 |
CRIK |
0.778 | 0.018 | -3 | 0.720 |
PKMYT1_TYR |
0.778 | 0.027 | 3 | 0.824 |
LIMK2_TYR |
0.778 | 0.075 | -3 | 0.904 |
BIKE |
0.777 | -0.037 | 1 | 0.567 |
MAP2K7_TYR |
0.775 | -0.125 | 2 | 0.844 |
MAP2K6_TYR |
0.775 | -0.015 | -1 | 0.852 |
MAP2K4_TYR |
0.775 | -0.078 | -1 | 0.855 |
ALPHAK3 |
0.774 | -0.069 | -1 | 0.755 |
PINK1_TYR |
0.773 | -0.135 | 1 | 0.696 |
ASK1 |
0.773 | -0.155 | 1 | 0.625 |
BMPR2_TYR |
0.773 | -0.028 | -1 | 0.821 |
PDHK1_TYR |
0.772 | -0.064 | -1 | 0.861 |
MYO3B |
0.772 | -0.099 | 2 | 0.799 |
MYO3A |
0.772 | -0.104 | 1 | 0.634 |
RET |
0.770 | -0.123 | 1 | 0.652 |
LIMK1_TYR |
0.768 | -0.086 | 2 | 0.837 |
TAO1 |
0.767 | -0.147 | 1 | 0.600 |
CSF1R |
0.766 | -0.104 | 3 | 0.765 |
TYRO3 |
0.764 | -0.166 | 3 | 0.771 |
TYK2 |
0.764 | -0.227 | 1 | 0.639 |
EPHA6 |
0.763 | -0.116 | -1 | 0.826 |
MST1R |
0.763 | -0.170 | 3 | 0.771 |
AAK1 |
0.762 | -0.006 | 1 | 0.496 |
DDR1 |
0.762 | -0.149 | 4 | 0.747 |
JAK2 |
0.762 | -0.177 | 1 | 0.652 |
ROS1 |
0.762 | -0.181 | 3 | 0.749 |
STLK3 |
0.762 | -0.173 | 1 | 0.600 |
NEK10_TYR |
0.761 | -0.094 | 1 | 0.574 |
TXK |
0.761 | -0.037 | 1 | 0.605 |
YES1 |
0.760 | -0.074 | -1 | 0.848 |
YANK3 |
0.760 | -0.105 | 2 | 0.382 |
EPHB4 |
0.760 | -0.149 | -1 | 0.823 |
JAK3 |
0.759 | -0.151 | 1 | 0.644 |
TNNI3K_TYR |
0.759 | -0.042 | 1 | 0.669 |
FGFR2 |
0.759 | -0.083 | 3 | 0.766 |
FGFR1 |
0.758 | -0.070 | 3 | 0.746 |
ABL2 |
0.757 | -0.128 | -1 | 0.828 |
KIT |
0.756 | -0.134 | 3 | 0.767 |
INSRR |
0.756 | -0.151 | 3 | 0.732 |
PDGFRB |
0.756 | -0.198 | 3 | 0.777 |
TNK1 |
0.756 | -0.105 | 3 | 0.751 |
TEK |
0.756 | -0.071 | 3 | 0.713 |
ITK |
0.755 | -0.111 | -1 | 0.809 |
FLT3 |
0.755 | -0.167 | 3 | 0.763 |
KDR |
0.754 | -0.117 | 3 | 0.734 |
FER |
0.754 | -0.207 | 1 | 0.628 |
TNK2 |
0.754 | -0.152 | 3 | 0.715 |
FGR |
0.753 | -0.196 | 1 | 0.620 |
SRMS |
0.753 | -0.148 | 1 | 0.613 |
CK1A |
0.753 | -0.069 | -3 | 0.441 |
ABL1 |
0.753 | -0.138 | -1 | 0.831 |
JAK1 |
0.753 | -0.130 | 1 | 0.607 |
AXL |
0.752 | -0.168 | 3 | 0.749 |
EPHA4 |
0.752 | -0.122 | 2 | 0.765 |
EPHB1 |
0.752 | -0.168 | 1 | 0.617 |
LCK |
0.751 | -0.103 | -1 | 0.818 |
HCK |
0.751 | -0.164 | -1 | 0.816 |
WEE1_TYR |
0.751 | -0.090 | -1 | 0.777 |
TEC |
0.750 | -0.115 | -1 | 0.765 |
EPHB3 |
0.749 | -0.175 | -1 | 0.814 |
MERTK |
0.748 | -0.166 | 3 | 0.744 |
EPHB2 |
0.748 | -0.155 | -1 | 0.809 |
DDR2 |
0.747 | -0.053 | 3 | 0.714 |
PDGFRA |
0.747 | -0.252 | 3 | 0.767 |
BLK |
0.747 | -0.095 | -1 | 0.812 |
FGFR3 |
0.746 | -0.109 | 3 | 0.742 |
BTK |
0.746 | -0.208 | -1 | 0.790 |
BMX |
0.746 | -0.117 | -1 | 0.716 |
FLT1 |
0.746 | -0.148 | -1 | 0.799 |
FLT4 |
0.745 | -0.167 | 3 | 0.732 |
MET |
0.744 | -0.170 | 3 | 0.743 |
PTK6 |
0.743 | -0.220 | -1 | 0.783 |
ALK |
0.743 | -0.202 | 3 | 0.699 |
ERBB2 |
0.742 | -0.198 | 1 | 0.598 |
FYN |
0.741 | -0.085 | -1 | 0.781 |
LTK |
0.741 | -0.200 | 3 | 0.720 |
NTRK1 |
0.741 | -0.251 | -1 | 0.816 |
EPHA7 |
0.741 | -0.165 | 2 | 0.767 |
NTRK2 |
0.740 | -0.230 | 3 | 0.727 |
FRK |
0.739 | -0.171 | -1 | 0.827 |
PTK2B |
0.739 | -0.102 | -1 | 0.826 |
INSR |
0.739 | -0.206 | 3 | 0.704 |
MATK |
0.738 | -0.131 | -1 | 0.766 |
CK1G3 |
0.738 | -0.062 | -3 | 0.395 |
EPHA1 |
0.737 | -0.208 | 3 | 0.721 |
EGFR |
0.736 | -0.126 | 1 | 0.533 |
LYN |
0.736 | -0.156 | 3 | 0.695 |
EPHA3 |
0.736 | -0.207 | 2 | 0.736 |
NTRK3 |
0.736 | -0.192 | -1 | 0.770 |
FGFR4 |
0.735 | -0.117 | -1 | 0.772 |
CSK |
0.733 | -0.172 | 2 | 0.763 |
EPHA5 |
0.732 | -0.173 | 2 | 0.756 |
SRC |
0.732 | -0.127 | -1 | 0.798 |
EPHA8 |
0.730 | -0.168 | -1 | 0.776 |
YANK2 |
0.728 | -0.126 | 2 | 0.402 |
PTK2 |
0.725 | -0.106 | -1 | 0.705 |
MUSK |
0.725 | -0.184 | 1 | 0.511 |
SYK |
0.722 | -0.126 | -1 | 0.706 |
IGF1R |
0.720 | -0.207 | 3 | 0.648 |
ERBB4 |
0.719 | -0.134 | 1 | 0.527 |
EPHA2 |
0.719 | -0.183 | -1 | 0.731 |
FES |
0.709 | -0.184 | -1 | 0.720 |
CK1G2 |
0.705 | -0.110 | -3 | 0.489 |
ZAP70 |
0.704 | -0.112 | -1 | 0.644 |