Motif 1165 (n=105)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NDE4 | RBMY1B | S488 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member B | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| A6NEQ0 | RBMY1E | S488 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member E | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| E9PB15 | PTGES3L | S159 | ochoa | Putative protein PTGES3L (Prostaglandin E synthase 3-like) | None |
| H3BTX0 | None | S75 | ochoa | PAXIP1-associated glutamate-rich protein 1 | None |
| O43353 | RIPK2 | S531 | ochoa | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) | Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}. |
| O75030 | MITF | S518 | ochoa | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) | Transcription factor that acts as a master regulator of melanocyte survival and differentiation as well as melanosome biogenesis (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoter of pigmentation genes, such as tyrosinase (TYR) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, MITF phosphorylation by MTOR promotes its inactivation (PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces MITF dephosphorylation, resulting in transcription factor activity (PubMed:36608670). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (PubMed:10587587, PubMed:22647378, PubMed:27889061, PubMed:9647758). {ECO:0000269|PubMed:10587587, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:27889061, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:9647758}. |
| O75496 | GMNN | S202 | psp | Geminin | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}. |
| O75691 | UTP20 | S2777 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O95436 | SLC34A2 | S683 | ochoa | Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) | Involved in actively transporting phosphate into cells via Na(+) cotransport. {ECO:0000269|PubMed:10329428}. |
| P04075 | ALDOA | S356 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P06127 | CD5 | S485 | ochoa|psp | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
| P06730 | EIF4E | S209 | ochoa|psp | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (PubMed:11606200, PubMed:22578813, PubMed:22684010, PubMed:24335285, PubMed:29987188). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (PubMed:29987188). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (PubMed:23471078). Promotes the nuclear export of MDM2 mRNA (PubMed:22684010). Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). {ECO:0000250|UniProtKB:P63073, ECO:0000250|UniProtKB:P63074, ECO:0000269|PubMed:11606200, ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:23471078, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:29987188}. |
| P09651 | HNRNPA1 | S363 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P09651 | HNRNPA1 | S364 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P09651 | HNRNPA1 | S365 | ochoa | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P0C7P1 | RBMY1D | S488 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member D | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. |
| P0DJD3 | RBMY1A1 | S488 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}. |
| P0DJD4 | RBMY1C | S488 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member C | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
| P0DMV8 | HSPA1A | S633 | ochoa|psp | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S633 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P11142 | HSPA8 | S638 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P13612 | ITGA4 | S1023 | ochoa | Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:35802072}. |
| P15408 | FOSL2 | S317 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P16455 | MGMT | S199 | ochoa | Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) | Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |
| P18858 | LIG1 | S911 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P19484 | TFEB | S469 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P25025 | CXCR2 | S353 | psp | C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182) | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. {ECO:0000269|PubMed:1891716, ECO:0000269|PubMed:8662698}. |
| P30518 | AVPR2 | S364 | psp | Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) | Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. {ECO:0000269|PubMed:19440390}. |
| P32241 | VIPR1 | S449 | ochoa | Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}. |
| P38432 | COIL | S568 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P42685 | FRK | S498 | ochoa | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| P46087 | NOP2 | S803 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P55040 | GEM | S289 | ochoa|psp | GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) | Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. |
| P55042 | RRAD | S301 | ochoa | GTP-binding protein RAD (RAD1) (Ras associated with diabetes) | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents (By similarity). Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (PubMed:18056528). {ECO:0000250|UniProtKB:O88667, ECO:0000269|PubMed:18056528}. |
| P55085 | F2RL1 | S389 | psp | Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2] | Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o)-alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. Probably mediates activation of pro-inflammatory and pro-fibrotic responses in fibroblasts, triggered by coagulation factor Xa (F10) (By similarity). Mediates activation of barrier protective signaling responses in endothelial cells, triggered by coagulation factor Xa (F10) (PubMed:22409427). {ECO:0000250|UniProtKB:P55086, ECO:0000269|PubMed:10086357, ECO:0000269|PubMed:10725339, ECO:0000269|PubMed:11413129, ECO:0000269|PubMed:11441110, ECO:0000269|PubMed:11447194, ECO:0000269|PubMed:11714832, ECO:0000269|PubMed:12832443, ECO:0000269|PubMed:15155775, ECO:0000269|PubMed:16359518, ECO:0000269|PubMed:16410250, ECO:0000269|PubMed:16478888, ECO:0000269|PubMed:16714334, ECO:0000269|PubMed:17404307, ECO:0000269|PubMed:17500066, ECO:0000269|PubMed:18424071, ECO:0000269|PubMed:18453611, ECO:0000269|PubMed:18474671, ECO:0000269|PubMed:18622013, ECO:0000269|PubMed:19494303, ECO:0000269|PubMed:19781631, ECO:0000269|PubMed:19864598, ECO:0000269|PubMed:19865078, ECO:0000269|PubMed:20826780, ECO:0000269|PubMed:21501162, ECO:0000269|PubMed:22409427, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:28445455}. |
| P55085 | F2RL1 | S390 | ochoa|psp | Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2] | Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o)-alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. Probably mediates activation of pro-inflammatory and pro-fibrotic responses in fibroblasts, triggered by coagulation factor Xa (F10) (By similarity). Mediates activation of barrier protective signaling responses in endothelial cells, triggered by coagulation factor Xa (F10) (PubMed:22409427). {ECO:0000250|UniProtKB:P55086, ECO:0000269|PubMed:10086357, ECO:0000269|PubMed:10725339, ECO:0000269|PubMed:11413129, ECO:0000269|PubMed:11441110, ECO:0000269|PubMed:11447194, ECO:0000269|PubMed:11714832, ECO:0000269|PubMed:12832443, ECO:0000269|PubMed:15155775, ECO:0000269|PubMed:16359518, ECO:0000269|PubMed:16410250, ECO:0000269|PubMed:16478888, ECO:0000269|PubMed:16714334, ECO:0000269|PubMed:17404307, ECO:0000269|PubMed:17500066, ECO:0000269|PubMed:18424071, ECO:0000269|PubMed:18453611, ECO:0000269|PubMed:18474671, ECO:0000269|PubMed:18622013, ECO:0000269|PubMed:19494303, ECO:0000269|PubMed:19781631, ECO:0000269|PubMed:19864598, ECO:0000269|PubMed:19865078, ECO:0000269|PubMed:20826780, ECO:0000269|PubMed:21501162, ECO:0000269|PubMed:22409427, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:28445455}. |
| P55735 | SEC13 | S313 | ochoa | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | Functions as a component of the nuclear pore complex (NPC) and the COPII coat (PubMed:8972206). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q9D1M0, ECO:0000269|PubMed:8972206}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| P61073 | CXCR4 | S344 | ochoa | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:18799424, PubMed:24912431, PubMed:28978524). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). {ECO:0000250|UniProtKB:P70658, ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10452968, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:17197449, ECO:0000269|PubMed:18799424, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:20228059, ECO:0000269|PubMed:20505072, ECO:0000269|PubMed:24912431, ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:8752280, ECO:0000269|PubMed:8752281}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:10074122, PubMed:10756055, PubMed:8849450, PubMed:8929542, PubMed:9427609). {ECO:0000269|PubMed:10074122, ECO:0000269|PubMed:10756055, ECO:0000269|PubMed:8849450, ECO:0000269|PubMed:8929542, ECO:0000269|PubMed:9427609}. |
| P62753 | RPS6 | S242 | ochoa|psp | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P84022 | SMAD3 | S418 | ochoa|psp | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}. |
| P98194 | ATP2C1 | S913 | ochoa | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) | ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:14632183, PubMed:20439740). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:10615129, PubMed:14632183, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}. |
| Q13148 | TARDBP | S407 | psp | TAR DNA-binding protein 43 (TDP-43) | RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:19765185, PubMed:23398327). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:19760257, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:21358640, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:23519609, ECO:0000269|PubMed:24240615, ECO:0000269|PubMed:24464995, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:29438978, ECO:0000269|PubMed:30464263, ECO:0000269|PubMed:30520513}. |
| Q13158 | FADD | S200 | psp | FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:23955153, PubMed:24025841, PubMed:7538907, PubMed:9184224). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:7538907, PubMed:9184224). Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225, PubMed:24204270). {ECO:0000269|PubMed:16762833, ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:21109225, ECO:0000269|PubMed:23955153, ECO:0000269|PubMed:24025841, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:7538907, ECO:0000269|PubMed:9184224}. |
| Q13610 | PWP1 | S494 | ochoa | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}. |
| Q13613 | MTMR1 | S657 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}. |
| Q14135 | VGLL4 | S283 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
| Q15149 | PLEC | S4675 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15415 | RBMY1F | S488 | ochoa | RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2) | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. {ECO:0000269|PubMed:8269511}. |
| Q15773 | MLF2 | S240 | ochoa | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | None |
| Q15796 | SMAD2 | S460 | ochoa | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q2M389 | WASHC4 | S1164 | ochoa | WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000303|PubMed:21498477}. |
| Q32P44 | EML3 | S889 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q3YBR2 | TBRG1 | S402 | ochoa | Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2) | Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269|PubMed:17110379}. |
| Q5F1R6 | DNAJC21 | S523 | ochoa | DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) (Protein GS3) | May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA. {ECO:0000269|PubMed:27346687}. |
| Q5W0B1 | OBI1 | S719 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q5ZPR3 | CD276 | S525 | ochoa | CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}. |
| Q66GS9 | CEP135 | S1132 | ochoa | Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) | Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27477386}. |
| Q68DH5 | LMBRD2 | S687 | ochoa | G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2) | Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway (PubMed:28388415). May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable). {ECO:0000269|PubMed:28388415, ECO:0000305|PubMed:28388415}. |
| Q6P597 | KLC3 | S497 | ochoa | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}. |
| Q6P9B9 | INTS5 | S1012 | ochoa | Integrator complex subunit 5 (Int5) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q6PHR2 | ULK3 | S464 | ochoa | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}. |
| Q7L5D6 | GET4 | S319 | ochoa | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}. |
| Q7Z460 | CLASP1 | S1530 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z460 | CLASP1 | S1531 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z460 | CLASP1 | S1532 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q86UE8 | TLK2 | S763 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86VP6 | CAND1 | S1221 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q86W92 | PPFIBP1 | S1003 | ochoa | Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) | May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}. |
| Q86WC4 | OSTM1 | S325 | ochoa | Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) | Required for osteoclast and melanocyte maturation and function. {ECO:0000250, ECO:0000269|PubMed:21527911}. |
| Q8IYK8 | REM2 | S333 | ochoa | GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) | Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}. |
| Q8N3C0 | ASCC3 | S2195 | ochoa | Activating signal cointegrator 1 complex subunit 3 (EC 5.6.2.4) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200) | ATPase involved both in DNA repair and rescue of stalled ribosomes (PubMed:22055184, PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184, ECO:0000269|PubMed:28757607, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q8WWN9 | IPCEF1 | S429 | ochoa | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}. |
| Q96EQ0 | SGTB | S295 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250}. |
| Q96EQ0 | SGTB | S297 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250}. |
| Q96EY7 | PTCD3 | S681 | ochoa | Small ribosomal subunit protein mS39 (28S ribosomal protein S39, mitochondrial) (MRP-S39) (Pentatricopeptide repeat domain-containing protein 3, mitochondrial) (Transformation-related gene 15 protein) (TRG-15) | Mitochondrial RNA-binding protein that has a role in mitochondrial translation. {ECO:0000269|PubMed:19427859}. |
| Q96N67 | DOCK7 | S2131 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96QT4 | TRPM7 | S1857 | ochoa | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q9BQA9 | CYBC1 | S178 | ochoa | Cytochrome b-245 chaperone 1 (Essential for reactive oxygen species protein) (Eros) | Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (PubMed:30361506). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity). {ECO:0000250|UniProtKB:Q3TYS2, ECO:0000269|PubMed:30361506}. |
| Q9BTK6 | PAGR1 | S245 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9BTV5 | FSD1 | S489 | ochoa | Fibronectin type III and SPRY domain-containing protein 1 (MID1-related protein 1) (Microtubule-associated protein GLFND) | May be involved in microtubule organization and stabilization. {ECO:0000269|PubMed:12154070, ECO:0000269|PubMed:12445389}. |
| Q9BU23 | LMF2 | S699 | ochoa | Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153) | Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). {ECO:0000250}. |
| Q9BU23 | LMF2 | S700 | ochoa | Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153) | Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). {ECO:0000250}. |
| Q9BV73 | CEP250 | S2435 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BXM9 | FSD1L | S522 | ochoa | FSD1-like protein (Coiled-coil domain-containing protein 10) (FSD1 N-terminal-like protein) | None |
| Q9H1R3 | MYLK2 | S588 | ochoa | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| Q9HB20 | PLEKHA3 | S291 | ochoa | Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1) | Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}. |
| Q9HCM7 | FBRSL1 | S1036 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NSK0 | KLC4 | S611 | ochoa | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250}. |
| Q9NT99 | LRRC4B | S704 | ochoa | Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3) | Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). {ECO:0000250}. |
| Q9NV56 | MRGBP | S197 | ochoa | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Q9NZJ5 | EIF2AK3 | S1109 | ochoa | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:10026192, ECO:0000269|PubMed:10677345, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:12086964, ECO:0000269|PubMed:25925385, ECO:0000269|PubMed:27917829, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:39116259}. |
| Q9P296 | C5AR2 | S328 | ochoa | C5a anaphylatoxin chemotactic receptor 2 (Complement component 5a receptor 2) (G-protein coupled receptor 77) | Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. {ECO:0000269|PubMed:11773063, ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:19615750}. |
| Q9P2N7 | KLHL13 | S647 | ochoa | Kelch-like protein 13 (BTB and kelch domain-containing protein 2) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:19995937}. |
| Q9UJS0 | SLC25A13 | S668 | ochoa | Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (Calcium-binding mitochondrial carrier protein Aralar2) (ARALAR-related gene 2) (ARALAR2) (Citrin) (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13) | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards gamma-aminobutyric acid (GABA) (PubMed:38945283). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:38945283}. |
| Q9ULD2 | MTUS1 | S1261 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9UNS2 | COPS3 | S415 | ochoa | COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. |
| Q9Y289 | SLC5A6 | S626 | ochoa | Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6) | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed:21570947, PubMed:22015582, PubMed:25809983, PubMed:25971966, PubMed:27904971, PubMed:28052864, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983). {ECO:0000250|UniProtKB:Q5U4D8, ECO:0000269|PubMed:10329687, ECO:0000269|PubMed:15561972, ECO:0000269|PubMed:19211916, ECO:0000269|PubMed:20980265, ECO:0000269|PubMed:21570947, ECO:0000269|PubMed:22015582, ECO:0000269|PubMed:25809983, ECO:0000269|PubMed:25971966, ECO:0000269|PubMed:27904971, ECO:0000269|PubMed:28052864, ECO:0000269|PubMed:31754459}. |
| Q9Y2E8 | SLC9A8 | S573 | ochoa | Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) | Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (PubMed:15522866). Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (PubMed:15522866, PubMed:20719963). In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity). Can also be active at the cell surface of specialized cells. In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (PubMed:34288721). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (By similarity). Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity). {ECO:0000250|UniProtKB:Q8R4D1, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:20719963, ECO:0000269|PubMed:34288721}. |
| Q9Y597 | KCTD3 | S808 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y5U2 | TSSC4 | S321 | ochoa | U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) | Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}. |
| Q9Y653 | ADGRG1 | S685 | ochoa | Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: Adhesion G-protein coupled receptor G1, N-terminal fragment (ADGRG1 N-terminal fragment) (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); Adhesion G-protein coupled receptor G1, C-terminal fragment (ADGRG1 C-terminal fragment) (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)] | Adhesion G-protein coupled receptor (aGPCR) for steroid hormone 17alpha-hydroxypregnenolone (17-OH), which is involved in cell adhesion and cell-cell interactions (PubMed:39389061). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:28874577, PubMed:35418682, PubMed:39389061). ADGRG1 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases (PubMed:22238662, PubMed:28424266, PubMed:35418682, PubMed:39389061). Acts as a potent suppressor of ferroptosis: binding to 17-OH-binding initiates signaling that down-regulates CD36 and alleviates ferroptosis-induced liver injury (By similarity). Ligand-binding also induces cell adhesion activity via association with proteins such as collagen III/COL3A1 and TGM2 (By similarity). Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells (By similarity). Involved in cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination: association with COL3A1 in the developing brain inhibits neuronal migration via activation of the RhoA pathway (PubMed:24531968). Together with TGM2, acts as a regulator of myelination and myelin repair in oligodendrocyte precursor cells (By similarity). Acts as a hemostatic sensor of shear force: G protein-coupled receptor signaling is activated in response to shear force in platelets, promoting G(13) G protein signaling, and platelet shape change and aggregation in a COL3A1-dependent manner (PubMed:33097663). Acts as an inhibitor of VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:19572147, PubMed:21724588). Plays a role in the maintenance of hematopoietic stem cells in bone marrow niche (By similarity). Plays an essential role in testis development (By similarity). {ECO:0000250|UniProtKB:Q8K209, ECO:0000269|PubMed:16757564, ECO:0000269|PubMed:19572147, ECO:0000269|PubMed:21724588, ECO:0000269|PubMed:22238662, ECO:0000269|PubMed:24531968, ECO:0000269|PubMed:28424266, ECO:0000269|PubMed:28874577, ECO:0000269|PubMed:33097663, ECO:0000269|PubMed:35418682, ECO:0000269|PubMed:39389061}. |
| Q9Y653 | ADGRG1 | S687 | ochoa | Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: Adhesion G-protein coupled receptor G1, N-terminal fragment (ADGRG1 N-terminal fragment) (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); Adhesion G-protein coupled receptor G1, C-terminal fragment (ADGRG1 C-terminal fragment) (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)] | Adhesion G-protein coupled receptor (aGPCR) for steroid hormone 17alpha-hydroxypregnenolone (17-OH), which is involved in cell adhesion and cell-cell interactions (PubMed:39389061). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:28874577, PubMed:35418682, PubMed:39389061). ADGRG1 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases (PubMed:22238662, PubMed:28424266, PubMed:35418682, PubMed:39389061). Acts as a potent suppressor of ferroptosis: binding to 17-OH-binding initiates signaling that down-regulates CD36 and alleviates ferroptosis-induced liver injury (By similarity). Ligand-binding also induces cell adhesion activity via association with proteins such as collagen III/COL3A1 and TGM2 (By similarity). Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells (By similarity). Involved in cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination: association with COL3A1 in the developing brain inhibits neuronal migration via activation of the RhoA pathway (PubMed:24531968). Together with TGM2, acts as a regulator of myelination and myelin repair in oligodendrocyte precursor cells (By similarity). Acts as a hemostatic sensor of shear force: G protein-coupled receptor signaling is activated in response to shear force in platelets, promoting G(13) G protein signaling, and platelet shape change and aggregation in a COL3A1-dependent manner (PubMed:33097663). Acts as an inhibitor of VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:19572147, PubMed:21724588). Plays a role in the maintenance of hematopoietic stem cells in bone marrow niche (By similarity). Plays an essential role in testis development (By similarity). {ECO:0000250|UniProtKB:Q8K209, ECO:0000269|PubMed:16757564, ECO:0000269|PubMed:19572147, ECO:0000269|PubMed:21724588, ECO:0000269|PubMed:22238662, ECO:0000269|PubMed:24531968, ECO:0000269|PubMed:28424266, ECO:0000269|PubMed:28874577, ECO:0000269|PubMed:33097663, ECO:0000269|PubMed:35418682, ECO:0000269|PubMed:39389061}. |
| Q8TA86 | RP9 | S214 | SIGNOR | Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) | Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity). {ECO:0000250}. |
| Q8TDU6 | GPBAR1 | S323 | PSP | G-protein coupled bile acid receptor 1 (G-protein coupled receptor GPCR19) (hGPCR19) (Membrane-type receptor for bile acids) (M-BAR) (hBG37) (BG37) | Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. {ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}. |
| P78543 | BTG2 | S149 | GPS6 | Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3) | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.332268e-15 | 14.875 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.344791e-13 | 12.630 |
| R-HSA-3371511 | HSF1 activation | 1.638134e-12 | 11.786 |
| R-HSA-3371556 | Cellular response to heat stress | 2.470246e-12 | 11.607 |
| R-HSA-9823730 | Formation of definitive endoderm | 4.133305e-05 | 4.384 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 8.431973e-05 | 4.074 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 2.442124e-04 | 3.612 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 2.442124e-04 | 3.612 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 2.442124e-04 | 3.612 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 9.626734e-04 | 3.017 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 1.303943e-03 | 2.885 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 1.303943e-03 | 2.885 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 1.694845e-03 | 2.771 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 2.134635e-03 | 2.671 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 2.134635e-03 | 2.671 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 2.622578e-03 | 2.581 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.028941e-03 | 2.519 |
| R-HSA-375276 | Peptide ligand-binding receptors | 4.530552e-03 | 2.344 |
| R-HSA-2262752 | Cellular responses to stress | 4.576841e-03 | 2.339 |
| R-HSA-9796292 | Formation of axial mesoderm | 7.326374e-03 | 2.135 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.269460e-03 | 2.083 |
| R-HSA-73942 | DNA Damage Reversal | 9.063559e-03 | 2.043 |
| R-HSA-1502540 | Signaling by Activin | 9.063559e-03 | 2.043 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 9.994327e-03 | 2.000 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 9.156116e-03 | 2.038 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.630741e-03 | 2.016 |
| R-HSA-9827857 | Specification of primordial germ cells | 1.197696e-02 | 1.922 |
| R-HSA-5657655 | MGMT-mediated DNA damage reversal | 1.479445e-02 | 1.830 |
| R-HSA-9036092 | Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus... | 1.479445e-02 | 1.830 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.642217e-02 | 1.785 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.642217e-02 | 1.785 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.829878e-02 | 1.738 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.411680e-02 | 1.850 |
| R-HSA-1181150 | Signaling by NODAL | 1.524411e-02 | 1.817 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.884820e-02 | 1.725 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.884820e-02 | 1.725 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 1.761041e-02 | 1.754 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.642217e-02 | 1.785 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.884820e-02 | 1.725 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 1.640885e-02 | 1.785 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.310585e-02 | 1.883 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.961340e-02 | 1.707 |
| R-HSA-5687583 | Defective SLC34A2 causes PALM | 2.211007e-02 | 1.655 |
| R-HSA-5619045 | Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) | 2.211007e-02 | 1.655 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.312303e-02 | 1.636 |
| R-HSA-380287 | Centrosome maturation | 2.461620e-02 | 1.609 |
| R-HSA-6798695 | Neutrophil degranulation | 2.711064e-02 | 1.567 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 2.555993e-02 | 1.592 |
| R-HSA-9833482 | PKR-mediated signaling | 2.857209e-02 | 1.544 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 3.658009e-02 | 1.437 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 4.373528e-02 | 1.359 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 5.083776e-02 | 1.294 |
| R-HSA-446107 | Type I hemidesmosome assembly | 7.872833e-02 | 1.104 |
| R-HSA-112126 | ALKBH3 mediated reversal of alkylation damage | 7.872833e-02 | 1.104 |
| R-HSA-3371378 | Regulation by c-FLIP | 7.872833e-02 | 1.104 |
| R-HSA-69416 | Dimerization of procaspase-8 | 7.872833e-02 | 1.104 |
| R-HSA-9613354 | Lipophagy | 8.557303e-02 | 1.068 |
| R-HSA-5218900 | CASP8 activity is inhibited | 8.557303e-02 | 1.068 |
| R-HSA-9700645 | ALK mutants bind TKIs | 8.557303e-02 | 1.068 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 9.911149e-02 | 1.004 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.124511e-01 | 0.949 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.468932e-02 | 1.460 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.631728e-02 | 1.440 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.385456e-01 | 0.858 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.667631e-02 | 1.331 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 1.576159e-01 | 0.802 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.849670e-02 | 1.314 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 1.884736e-01 | 0.725 |
| R-HSA-429947 | Deadenylation of mRNA | 2.005005e-01 | 0.698 |
| R-HSA-72649 | Translation initiation complex formation | 7.861178e-02 | 1.105 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 8.298081e-02 | 1.081 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 3.649019e-02 | 1.438 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 8.742271e-02 | 1.058 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.297998e-01 | 0.639 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.355306e-01 | 0.628 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.412191e-01 | 0.618 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.412191e-01 | 0.618 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.524706e-01 | 0.598 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.690382e-01 | 0.570 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.556688e-01 | 0.808 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.556688e-01 | 0.808 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.846616e-01 | 0.734 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.252651e-01 | 0.647 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.453624e-01 | 0.838 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.310829e-01 | 0.882 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 1.823931e-01 | 0.739 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.838759e-02 | 1.416 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 1.762674e-01 | 0.754 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.311403e-02 | 1.365 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 8.298081e-02 | 1.081 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.527031e-01 | 0.597 |
| R-HSA-173107 | Binding and entry of HIV virion | 9.236729e-02 | 1.034 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.884736e-01 | 0.725 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 3.309087e-02 | 1.480 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.527031e-01 | 0.597 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.847620e-01 | 0.733 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 4.373528e-02 | 1.359 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 7.183283e-02 | 1.144 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.797425e-02 | 1.421 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.762674e-01 | 0.754 |
| R-HSA-75157 | FasL/ CD95L signaling | 3.658009e-02 | 1.437 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.123505e-01 | 0.673 |
| R-HSA-388479 | Vasopressin-like receptors | 4.373528e-02 | 1.359 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.195881e-01 | 0.922 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.007894e-01 | 0.697 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 2.635565e-01 | 0.579 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.927027e-01 | 0.715 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 2.123505e-01 | 0.673 |
| R-HSA-427589 | Type II Na+/Pi cotransporters | 3.658009e-02 | 1.437 |
| R-HSA-75158 | TRAIL signaling | 5.788792e-02 | 1.237 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 5.788792e-02 | 1.237 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.137313e-02 | 1.383 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.576159e-01 | 0.802 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.823931e-01 | 0.739 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.798804e-01 | 0.553 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.576159e-01 | 0.802 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.011526e-01 | 0.696 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.124511e-01 | 0.949 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 1.700962e-01 | 0.769 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 9.236729e-02 | 1.034 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 3.309087e-02 | 1.480 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.192830e-02 | 1.208 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.580341e-01 | 0.588 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.058060e-01 | 0.975 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.700962e-01 | 0.769 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.762674e-01 | 0.754 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.196529e-02 | 1.495 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.116323e-01 | 0.674 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.252651e-01 | 0.647 |
| R-HSA-68877 | Mitotic Prometaphase | 7.478021e-02 | 1.126 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.602891e-02 | 1.252 |
| R-HSA-72312 | rRNA processing | 2.900534e-01 | 0.538 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.123505e-01 | 0.673 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.664643e-01 | 0.574 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.058060e-01 | 0.975 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.320942e-01 | 0.879 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.355306e-01 | 0.628 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.635565e-01 | 0.579 |
| R-HSA-381042 | PERK regulates gene expression | 2.690382e-01 | 0.570 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 5.788792e-02 | 1.237 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 7.183283e-02 | 1.144 |
| R-HSA-425986 | Sodium/Proton exchangers | 7.872833e-02 | 1.104 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 2.905632e-01 | 0.537 |
| R-HSA-983189 | Kinesins | 9.193440e-02 | 1.037 |
| R-HSA-447041 | CHL1 interactions | 7.183283e-02 | 1.144 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.823931e-01 | 0.739 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.355306e-01 | 0.628 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.580341e-01 | 0.588 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.852416e-01 | 0.545 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.280002e-01 | 0.642 |
| R-HSA-9758941 | Gastrulation | 3.691044e-02 | 1.433 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.635565e-01 | 0.579 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.900170e-01 | 0.721 |
| R-HSA-8951664 | Neddylation | 1.065948e-01 | 0.972 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.513061e-01 | 0.820 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 2.005005e-01 | 0.698 |
| R-HSA-8875878 | MET promotes cell motility | 2.852416e-01 | 0.545 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.905632e-01 | 0.537 |
| R-HSA-5617833 | Cilium Assembly | 2.049668e-01 | 0.688 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.753452e-02 | 1.323 |
| R-HSA-69275 | G2/M Transition | 6.794321e-02 | 1.168 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.986197e-02 | 1.156 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 1.124511e-01 | 0.949 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.255949e-01 | 0.901 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.255949e-01 | 0.901 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.320942e-01 | 0.879 |
| R-HSA-3295583 | TRP channels | 2.123505e-01 | 0.673 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.182101e-01 | 0.661 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.524706e-01 | 0.598 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.852416e-01 | 0.545 |
| R-HSA-168255 | Influenza Infection | 1.842148e-01 | 0.735 |
| R-HSA-70171 | Glycolysis | 2.007894e-01 | 0.697 |
| R-HSA-9839394 | TGFBR3 expression | 2.064474e-01 | 0.685 |
| R-HSA-420092 | Glucagon-type ligand receptors | 2.297998e-01 | 0.639 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.277060e-01 | 0.894 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.744794e-01 | 0.561 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.277060e-01 | 0.894 |
| R-HSA-6806834 | Signaling by MET | 1.402655e-01 | 0.853 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.340268e-02 | 1.079 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.852416e-01 | 0.545 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.124511e-01 | 0.949 |
| R-HSA-8876725 | Protein methylation | 1.320942e-01 | 0.879 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.513061e-01 | 0.820 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.762674e-01 | 0.754 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.355306e-01 | 0.628 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.170761e-01 | 0.663 |
| R-HSA-418555 | G alpha (s) signalling events | 1.695045e-01 | 0.771 |
| R-HSA-165159 | MTOR signalling | 5.410920e-02 | 1.267 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 8.557303e-02 | 1.068 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 9.236729e-02 | 1.034 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.513061e-01 | 0.820 |
| R-HSA-9629569 | Protein hydroxylation | 1.700962e-01 | 0.769 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.690382e-01 | 0.570 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.504976e-01 | 0.822 |
| R-HSA-70326 | Glucose metabolism | 2.554543e-01 | 0.593 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.980891e-01 | 0.703 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 1.768162e-01 | 0.752 |
| R-HSA-69186 | Lagging Strand Synthesis | 1.762674e-01 | 0.754 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 9.651289e-02 | 1.015 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 2.412191e-01 | 0.618 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.494581e-01 | 0.825 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.883516e-02 | 1.230 |
| R-HSA-9031628 | NGF-stimulated transcription | 6.597367e-02 | 1.181 |
| R-HSA-196780 | Biotin transport and metabolism | 1.320942e-01 | 0.879 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.320942e-01 | 0.879 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.203074e-01 | 0.920 |
| R-HSA-162587 | HIV Life Cycle | 1.429509e-01 | 0.845 |
| R-HSA-162906 | HIV Infection | 2.799491e-01 | 0.553 |
| R-HSA-69239 | Synthesis of DNA | 2.225326e-01 | 0.653 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 8.519285e-02 | 1.070 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 2.798804e-01 | 0.553 |
| R-HSA-69190 | DNA strand elongation | 2.468657e-01 | 0.608 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.301425e-01 | 0.638 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.307377e-01 | 0.637 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.307377e-01 | 0.637 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.170761e-01 | 0.663 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.203074e-01 | 0.920 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 2.580341e-01 | 0.588 |
| R-HSA-2672351 | Stimuli-sensing channels | 2.252651e-01 | 0.647 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.530788e-01 | 0.815 |
| R-HSA-983712 | Ion channel transport | 2.030576e-01 | 0.692 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.819673e-01 | 0.550 |
| R-HSA-5358508 | Mismatch Repair | 1.576159e-01 | 0.802 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 5.221362e-02 | 1.282 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.002912e-02 | 1.222 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.123505e-01 | 0.673 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 3.631493e-02 | 1.440 |
| R-HSA-500792 | GPCR ligand binding | 8.638958e-02 | 1.064 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.002912e-02 | 1.222 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 2.852416e-01 | 0.545 |
| R-HSA-5619102 | SLC transporter disorders | 1.604952e-01 | 0.795 |
| R-HSA-162582 | Signal Transduction | 1.877275e-01 | 0.726 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 5.797230e-02 | 1.237 |
| R-HSA-913531 | Interferon Signaling | 8.241897e-02 | 1.084 |
| R-HSA-1483255 | PI Metabolism | 2.062029e-01 | 0.686 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.884773e-01 | 0.540 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 3.797425e-02 | 1.421 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.524706e-01 | 0.598 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.468657e-01 | 0.608 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.768162e-01 | 0.752 |
| R-HSA-9679506 | SARS-CoV Infections | 2.598903e-01 | 0.585 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 7.431875e-02 | 1.129 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.905632e-01 | 0.537 |
| R-HSA-1266738 | Developmental Biology | 2.956355e-01 | 0.529 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.958455e-01 | 0.529 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.958455e-01 | 0.529 |
| R-HSA-1474165 | Reproduction | 2.967179e-01 | 0.528 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.010887e-01 | 0.521 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.010887e-01 | 0.521 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.010887e-01 | 0.521 |
| R-HSA-1640170 | Cell Cycle | 3.012911e-01 | 0.521 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.022044e-01 | 0.520 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.062933e-01 | 0.514 |
| R-HSA-8953854 | Metabolism of RNA | 3.071010e-01 | 0.513 |
| R-HSA-73894 | DNA Repair | 3.146768e-01 | 0.502 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.205036e-01 | 0.494 |
| R-HSA-9948299 | Ribosome-associated quality control | 3.213454e-01 | 0.493 |
| R-HSA-5683826 | Surfactant metabolism | 3.216775e-01 | 0.493 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.267300e-01 | 0.486 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.267300e-01 | 0.486 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.267300e-01 | 0.486 |
| R-HSA-382551 | Transport of small molecules | 3.310625e-01 | 0.480 |
| R-HSA-372790 | Signaling by GPCR | 3.315754e-01 | 0.479 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 3.317452e-01 | 0.479 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 3.317452e-01 | 0.479 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.317452e-01 | 0.479 |
| R-HSA-9839373 | Signaling by TGFBR3 | 3.317452e-01 | 0.479 |
| R-HSA-75153 | Apoptotic execution phase | 3.317452e-01 | 0.479 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 3.349425e-01 | 0.475 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.367233e-01 | 0.473 |
| R-HSA-5688426 | Deubiquitination | 3.367759e-01 | 0.473 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 3.416647e-01 | 0.466 |
| R-HSA-70263 | Gluconeogenesis | 3.416647e-01 | 0.466 |
| R-HSA-425410 | Metal ion SLC transporters | 3.416647e-01 | 0.466 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.416647e-01 | 0.466 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.511550e-01 | 0.455 |
| R-HSA-69242 | S Phase | 3.511550e-01 | 0.455 |
| R-HSA-166520 | Signaling by NTRKs | 3.511550e-01 | 0.455 |
| R-HSA-9824446 | Viral Infection Pathways | 3.519244e-01 | 0.454 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.530327e-01 | 0.452 |
| R-HSA-68886 | M Phase | 3.534747e-01 | 0.452 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.618904e-01 | 0.441 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.618904e-01 | 0.441 |
| R-HSA-9609507 | Protein localization | 3.645643e-01 | 0.438 |
| R-HSA-69306 | DNA Replication | 3.645643e-01 | 0.438 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 3.658291e-01 | 0.437 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.658291e-01 | 0.437 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.658291e-01 | 0.437 |
| R-HSA-73887 | Death Receptor Signaling | 3.672340e-01 | 0.435 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.698994e-01 | 0.432 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.700092e-01 | 0.432 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.705554e-01 | 0.431 |
| R-HSA-9711097 | Cellular response to starvation | 3.778695e-01 | 0.423 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.799034e-01 | 0.420 |
| R-HSA-75893 | TNF signaling | 3.799034e-01 | 0.420 |
| R-HSA-177929 | Signaling by EGFR | 3.799034e-01 | 0.420 |
| R-HSA-388396 | GPCR downstream signalling | 3.812038e-01 | 0.419 |
| R-HSA-199991 | Membrane Trafficking | 3.813974e-01 | 0.419 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.831601e-01 | 0.417 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.845257e-01 | 0.415 |
| R-HSA-109581 | Apoptosis | 3.884318e-01 | 0.411 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.936679e-01 | 0.405 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.936679e-01 | 0.405 |
| R-HSA-191859 | snRNP Assembly | 3.936679e-01 | 0.405 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.936679e-01 | 0.405 |
| R-HSA-180786 | Extension of Telomeres | 3.936679e-01 | 0.405 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.936839e-01 | 0.405 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.026755e-01 | 0.395 |
| R-HSA-445717 | Aquaporin-mediated transport | 4.026755e-01 | 0.395 |
| R-HSA-450294 | MAP kinase activation | 4.026755e-01 | 0.395 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.071293e-01 | 0.390 |
| R-HSA-1268020 | Mitochondrial protein import | 4.071293e-01 | 0.390 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.119047e-01 | 0.385 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.159386e-01 | 0.381 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.159386e-01 | 0.381 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.196325e-01 | 0.377 |
| R-HSA-168249 | Innate Immune System | 4.247538e-01 | 0.372 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 4.305130e-01 | 0.366 |
| R-HSA-72766 | Translation | 4.325258e-01 | 0.364 |
| R-HSA-5218859 | Regulated Necrosis | 4.331694e-01 | 0.363 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.415948e-01 | 0.355 |
| R-HSA-448424 | Interleukin-17 signaling | 4.415948e-01 | 0.355 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.457608e-01 | 0.351 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.498960e-01 | 0.347 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.498960e-01 | 0.347 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.540006e-01 | 0.343 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.540006e-01 | 0.343 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.580749e-01 | 0.339 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 4.580749e-01 | 0.339 |
| R-HSA-917937 | Iron uptake and transport | 4.621189e-01 | 0.335 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.648780e-01 | 0.333 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.662486e-01 | 0.331 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.673318e-01 | 0.330 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.722197e-01 | 0.326 |
| R-HSA-216083 | Integrin cell surface interactions | 4.740725e-01 | 0.324 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 4.818947e-01 | 0.317 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.818947e-01 | 0.317 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 4.867226e-01 | 0.313 |
| R-HSA-72172 | mRNA Splicing | 4.986199e-01 | 0.302 |
| R-HSA-5357801 | Programmed Cell Death | 5.009785e-01 | 0.300 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.083750e-01 | 0.294 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.083750e-01 | 0.294 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 5.126122e-01 | 0.290 |
| R-HSA-156902 | Peptide chain elongation | 5.156912e-01 | 0.288 |
| R-HSA-9663891 | Selective autophagy | 5.156912e-01 | 0.288 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.156912e-01 | 0.288 |
| R-HSA-168256 | Immune System | 5.196246e-01 | 0.284 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 5.205962e-01 | 0.283 |
| R-HSA-73884 | Base Excision Repair | 5.228994e-01 | 0.282 |
| R-HSA-112310 | Neurotransmitter release cycle | 5.228994e-01 | 0.282 |
| R-HSA-202424 | Downstream TCR signaling | 5.228994e-01 | 0.282 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 5.228994e-01 | 0.282 |
| R-HSA-68882 | Mitotic Anaphase | 5.264529e-01 | 0.279 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.264635e-01 | 0.279 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 5.287255e-01 | 0.277 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.300012e-01 | 0.276 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 5.335126e-01 | 0.273 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 5.335126e-01 | 0.273 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.369981e-01 | 0.270 |
| R-HSA-1474290 | Collagen formation | 5.404577e-01 | 0.267 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.438917e-01 | 0.264 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.473003e-01 | 0.262 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.473003e-01 | 0.262 |
| R-HSA-5389840 | Mitochondrial translation elongation | 5.506836e-01 | 0.259 |
| R-HSA-157579 | Telomere Maintenance | 5.540418e-01 | 0.256 |
| R-HSA-5368286 | Mitochondrial translation initiation | 5.573751e-01 | 0.254 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.573751e-01 | 0.254 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.573751e-01 | 0.254 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.573751e-01 | 0.254 |
| R-HSA-190236 | Signaling by FGFR | 5.573751e-01 | 0.254 |
| R-HSA-3214847 | HATs acetylate histones | 5.606837e-01 | 0.251 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.606837e-01 | 0.251 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.672275e-01 | 0.246 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.672275e-01 | 0.246 |
| R-HSA-192823 | Viral mRNA Translation | 5.736747e-01 | 0.241 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 5.736747e-01 | 0.241 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.768624e-01 | 0.239 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.800265e-01 | 0.237 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.800265e-01 | 0.237 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.820532e-01 | 0.235 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.872886e-01 | 0.231 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 5.893788e-01 | 0.230 |
| R-HSA-211000 | Gene Silencing by RNA | 5.893788e-01 | 0.230 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 5.924501e-01 | 0.227 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 5.924501e-01 | 0.227 |
| R-HSA-5419276 | Mitochondrial translation termination | 5.954986e-01 | 0.225 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.954986e-01 | 0.225 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 5.954986e-01 | 0.225 |
| R-HSA-202403 | TCR signaling | 5.985245e-01 | 0.223 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.045091e-01 | 0.219 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.045091e-01 | 0.219 |
| R-HSA-1483249 | Inositol phosphate metabolism | 6.045091e-01 | 0.219 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 6.052228e-01 | 0.218 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.074682e-01 | 0.216 |
| R-HSA-422475 | Axon guidance | 6.119126e-01 | 0.213 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.154790e-01 | 0.211 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.162142e-01 | 0.210 |
| R-HSA-418594 | G alpha (i) signalling events | 6.212525e-01 | 0.207 |
| R-HSA-373760 | L1CAM interactions | 6.219373e-01 | 0.206 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 6.303636e-01 | 0.200 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 6.303636e-01 | 0.200 |
| R-HSA-68875 | Mitotic Prophase | 6.331307e-01 | 0.199 |
| R-HSA-73886 | Chromosome Maintenance | 6.358773e-01 | 0.197 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.386035e-01 | 0.195 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.386035e-01 | 0.195 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.413095e-01 | 0.193 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.439954e-01 | 0.191 |
| R-HSA-977606 | Regulation of Complement cascade | 6.466614e-01 | 0.189 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.493075e-01 | 0.188 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.493075e-01 | 0.188 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.493075e-01 | 0.188 |
| R-HSA-69206 | G1/S Transition | 6.493075e-01 | 0.188 |
| R-HSA-114608 | Platelet degranulation | 6.545410e-01 | 0.184 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.603789e-01 | 0.180 |
| R-HSA-9675108 | Nervous system development | 6.614418e-01 | 0.180 |
| R-HSA-9909396 | Circadian clock | 6.697811e-01 | 0.174 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.722555e-01 | 0.172 |
| R-HSA-1483257 | Phospholipid metabolism | 6.829123e-01 | 0.166 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.843543e-01 | 0.165 |
| R-HSA-5368287 | Mitochondrial translation | 6.867204e-01 | 0.163 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.867204e-01 | 0.163 |
| R-HSA-1280218 | Adaptive Immune System | 6.889372e-01 | 0.162 |
| R-HSA-6807070 | PTEN Regulation | 6.890689e-01 | 0.162 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 6.890689e-01 | 0.162 |
| R-HSA-1632852 | Macroautophagy | 6.937136e-01 | 0.159 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.982895e-01 | 0.156 |
| R-HSA-166658 | Complement cascade | 7.050266e-01 | 0.152 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.072389e-01 | 0.150 |
| R-HSA-112316 | Neuronal System | 7.093714e-01 | 0.149 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.094348e-01 | 0.149 |
| R-HSA-449147 | Signaling by Interleukins | 7.134908e-01 | 0.147 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.159250e-01 | 0.145 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.180563e-01 | 0.144 |
| R-HSA-597592 | Post-translational protein modification | 7.180758e-01 | 0.144 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 7.201717e-01 | 0.143 |
| R-HSA-109582 | Hemostasis | 7.216565e-01 | 0.142 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.243555e-01 | 0.140 |
| R-HSA-9612973 | Autophagy | 7.284772e-01 | 0.138 |
| R-HSA-9610379 | HCMV Late Events | 7.305151e-01 | 0.136 |
| R-HSA-74160 | Gene expression (Transcription) | 7.341128e-01 | 0.134 |
| R-HSA-1474244 | Extracellular matrix organization | 7.390231e-01 | 0.131 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.431380e-01 | 0.129 |
| R-HSA-2408522 | Selenoamino acid metabolism | 7.443617e-01 | 0.128 |
| R-HSA-212436 | Generic Transcription Pathway | 7.455807e-01 | 0.128 |
| R-HSA-72306 | tRNA processing | 7.575025e-01 | 0.121 |
| R-HSA-611105 | Respiratory electron transport | 7.717019e-01 | 0.113 |
| R-HSA-9609690 | HCMV Early Events | 8.007068e-01 | 0.097 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.095382e-01 | 0.092 |
| R-HSA-392499 | Metabolism of proteins | 8.202594e-01 | 0.086 |
| R-HSA-5663205 | Infectious disease | 8.324468e-01 | 0.080 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.458841e-01 | 0.073 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.470463e-01 | 0.072 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.516086e-01 | 0.070 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.549415e-01 | 0.068 |
| R-HSA-157118 | Signaling by NOTCH | 8.582002e-01 | 0.066 |
| R-HSA-4839726 | Chromatin organization | 8.675470e-01 | 0.062 |
| R-HSA-9609646 | HCMV Infection | 8.685471e-01 | 0.061 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.728847e-01 | 0.059 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.802812e-01 | 0.055 |
| R-HSA-416476 | G alpha (q) signalling events | 8.817863e-01 | 0.055 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.853198e-01 | 0.053 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 8.904247e-01 | 0.050 |
| R-HSA-446728 | Cell junction organization | 8.937021e-01 | 0.049 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 9.065802e-01 | 0.043 |
| R-HSA-1643685 | Disease | 9.202825e-01 | 0.036 |
| R-HSA-1500931 | Cell-Cell communication | 9.203707e-01 | 0.036 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.245029e-01 | 0.034 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.245029e-01 | 0.034 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.341776e-01 | 0.030 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 9.346775e-01 | 0.029 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.447701e-01 | 0.025 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.537671e-01 | 0.021 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.648281e-01 | 0.016 |
| R-HSA-5668914 | Diseases of metabolism | 9.661504e-01 | 0.015 |
| R-HSA-556833 | Metabolism of lipids | 9.999001e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GRK1 |
0.787 | 0.432 | -2 | 0.466 |
COT |
0.781 | 0.248 | 2 | 0.887 |
MOS |
0.771 | 0.360 | 1 | 0.886 |
CLK3 |
0.767 | 0.117 | 1 | 0.811 |
NDR2 |
0.767 | 0.104 | -3 | 0.727 |
PIM3 |
0.766 | 0.102 | -3 | 0.720 |
BMPR1B |
0.763 | 0.248 | 1 | 0.879 |
CDC7 |
0.762 | 0.131 | 1 | 0.875 |
KIS |
0.760 | 0.183 | 1 | 0.624 |
GRK7 |
0.760 | 0.276 | 1 | 0.789 |
PRKX |
0.759 | 0.064 | -3 | 0.622 |
RSK2 |
0.757 | 0.055 | -3 | 0.667 |
IKKB |
0.757 | 0.039 | -2 | 0.266 |
CK1E |
0.756 | 0.289 | -3 | 0.617 |
PIM1 |
0.754 | 0.073 | -3 | 0.681 |
NDR1 |
0.752 | 0.043 | -3 | 0.712 |
SKMLCK |
0.751 | 0.086 | -2 | 0.276 |
RSK4 |
0.751 | 0.076 | -3 | 0.652 |
PKACB |
0.750 | 0.030 | -2 | 0.165 |
AURC |
0.750 | 0.011 | -2 | 0.164 |
IKKA |
0.749 | 0.048 | -2 | 0.274 |
GRK3 |
0.748 | 0.196 | -2 | 0.382 |
GRK5 |
0.748 | 0.129 | -3 | 0.732 |
CK1D |
0.748 | 0.288 | -3 | 0.569 |
GRK6 |
0.748 | 0.151 | 1 | 0.861 |
CAMK2G |
0.748 | 0.051 | 2 | 0.822 |
LATS2 |
0.747 | 0.034 | -5 | 0.764 |
GRK2 |
0.747 | 0.168 | -2 | 0.352 |
CAMK1B |
0.747 | 0.023 | -3 | 0.721 |
CAMK2B |
0.746 | 0.065 | 2 | 0.813 |
PKACG |
0.746 | 0.011 | -2 | 0.204 |
CAMK2A |
0.746 | 0.065 | 2 | 0.838 |
GRK4 |
0.746 | 0.221 | -2 | 0.413 |
CLK2 |
0.745 | 0.078 | -3 | 0.659 |
RAF1 |
0.745 | 0.023 | 1 | 0.816 |
LATS1 |
0.745 | 0.095 | -3 | 0.737 |
DSTYK |
0.745 | 0.071 | 2 | 0.906 |
NUAK2 |
0.745 | 0.038 | -3 | 0.722 |
TGFBR1 |
0.744 | 0.118 | -2 | 0.331 |
PRPK |
0.744 | -0.001 | -1 | 0.730 |
MARK4 |
0.744 | 0.031 | 4 | 0.787 |
MTOR |
0.743 | -0.006 | 1 | 0.729 |
MAPKAPK2 |
0.742 | 0.022 | -3 | 0.623 |
BMPR1A |
0.742 | 0.163 | 1 | 0.860 |
P90RSK |
0.742 | 0.013 | -3 | 0.662 |
FAM20C |
0.742 | 0.065 | 2 | 0.630 |
CK2A2 |
0.742 | 0.164 | 1 | 0.811 |
HUNK |
0.742 | 0.096 | 2 | 0.804 |
PRKD2 |
0.741 | -0.003 | -3 | 0.662 |
PASK |
0.741 | 0.206 | -3 | 0.733 |
CK1A2 |
0.740 | 0.234 | -3 | 0.574 |
MST4 |
0.739 | 0.035 | 2 | 0.859 |
PKN2 |
0.739 | 0.028 | -3 | 0.703 |
AMPKA1 |
0.739 | 0.032 | -3 | 0.724 |
P70S6KB |
0.739 | 0.017 | -3 | 0.671 |
MSK1 |
0.738 | 0.016 | -3 | 0.624 |
PRKD1 |
0.738 | -0.027 | -3 | 0.687 |
ALK2 |
0.738 | 0.150 | -2 | 0.355 |
RSK3 |
0.738 | -0.007 | -3 | 0.652 |
SRPK1 |
0.738 | 0.016 | -3 | 0.643 |
GCN2 |
0.737 | -0.062 | 2 | 0.782 |
CDKL1 |
0.737 | 0.002 | -3 | 0.669 |
PKN3 |
0.737 | -0.005 | -3 | 0.687 |
QSK |
0.737 | 0.039 | 4 | 0.773 |
HIPK4 |
0.737 | -0.001 | 1 | 0.745 |
MARK3 |
0.736 | 0.059 | 4 | 0.751 |
ACVR2B |
0.736 | 0.104 | -2 | 0.308 |
CK2A1 |
0.736 | 0.162 | 1 | 0.799 |
TGFBR2 |
0.736 | -0.014 | -2 | 0.308 |
ALK4 |
0.735 | 0.084 | -2 | 0.323 |
NIK |
0.735 | -0.013 | -3 | 0.732 |
PDHK4 |
0.734 | -0.151 | 1 | 0.810 |
CAMK2D |
0.734 | -0.040 | -3 | 0.682 |
RIPK3 |
0.734 | 0.029 | 3 | 0.654 |
MYLK4 |
0.734 | 0.017 | -2 | 0.233 |
TBK1 |
0.733 | -0.072 | 1 | 0.684 |
NLK |
0.733 | -0.019 | 1 | 0.778 |
IKKE |
0.733 | -0.071 | 1 | 0.685 |
CAMLCK |
0.733 | -0.029 | -2 | 0.242 |
ACVR2A |
0.733 | 0.070 | -2 | 0.291 |
MLK1 |
0.732 | 0.020 | 2 | 0.813 |
BMPR2 |
0.732 | -0.082 | -2 | 0.291 |
AMPKA2 |
0.732 | 0.010 | -3 | 0.701 |
MSK2 |
0.732 | -0.020 | -3 | 0.621 |
CHAK2 |
0.732 | -0.022 | -1 | 0.726 |
WNK1 |
0.732 | -0.018 | -2 | 0.259 |
PAK1 |
0.731 | -0.020 | -2 | 0.206 |
AURA |
0.731 | -0.021 | -2 | 0.164 |
DAPK2 |
0.730 | -0.029 | -3 | 0.721 |
PKCD |
0.730 | -0.012 | 2 | 0.790 |
CDKL5 |
0.730 | -0.022 | -3 | 0.660 |
BRSK1 |
0.730 | 0.016 | -3 | 0.667 |
ATR |
0.730 | -0.053 | 1 | 0.742 |
PKACA |
0.730 | -0.006 | -2 | 0.140 |
MASTL |
0.730 | -0.071 | -2 | 0.268 |
AURB |
0.729 | -0.025 | -2 | 0.159 |
DLK |
0.729 | 0.024 | 1 | 0.804 |
ERK5 |
0.729 | -0.034 | 1 | 0.737 |
MAPKAPK3 |
0.729 | -0.050 | -3 | 0.645 |
SIK |
0.728 | 0.004 | -3 | 0.643 |
CLK4 |
0.728 | 0.005 | -3 | 0.668 |
TSSK2 |
0.728 | -0.039 | -5 | 0.735 |
TTBK2 |
0.727 | 0.084 | 2 | 0.697 |
SRPK2 |
0.727 | -0.003 | -3 | 0.575 |
QIK |
0.727 | -0.021 | -3 | 0.686 |
MLK3 |
0.727 | 0.011 | 2 | 0.756 |
NEK6 |
0.726 | -0.094 | -2 | 0.275 |
TSSK1 |
0.726 | -0.020 | -3 | 0.745 |
MARK2 |
0.726 | 0.023 | 4 | 0.728 |
PLK1 |
0.726 | -0.021 | -2 | 0.254 |
MARK1 |
0.726 | 0.026 | 4 | 0.752 |
ICK |
0.726 | -0.038 | -3 | 0.699 |
AKT2 |
0.726 | 0.008 | -3 | 0.598 |
PIM2 |
0.725 | 0.027 | -3 | 0.634 |
PKCB |
0.725 | 0.011 | 2 | 0.752 |
ULK2 |
0.725 | -0.172 | 2 | 0.753 |
CAMK1G |
0.725 | 0.018 | -3 | 0.631 |
CK1G1 |
0.725 | 0.165 | -3 | 0.602 |
CDK1 |
0.725 | 0.031 | 1 | 0.601 |
PKCG |
0.725 | 0.003 | 2 | 0.750 |
CAMK4 |
0.725 | -0.049 | -3 | 0.691 |
DYRK2 |
0.725 | -0.003 | 1 | 0.645 |
BCKDK |
0.724 | -0.082 | -1 | 0.663 |
PDHK1 |
0.724 | -0.211 | 1 | 0.783 |
NEK7 |
0.724 | -0.112 | -3 | 0.667 |
GSK3A |
0.724 | 0.093 | 4 | 0.480 |
SRPK3 |
0.723 | 0.003 | -3 | 0.610 |
PKG2 |
0.723 | -0.034 | -2 | 0.158 |
MEKK3 |
0.723 | 0.160 | 1 | 0.767 |
PLK3 |
0.723 | -0.008 | 2 | 0.784 |
HIPK2 |
0.722 | 0.027 | 1 | 0.564 |
SGK3 |
0.722 | -0.001 | -3 | 0.650 |
HIPK1 |
0.722 | 0.035 | 1 | 0.667 |
YSK4 |
0.722 | -0.029 | 1 | 0.738 |
DRAK1 |
0.721 | 0.044 | 1 | 0.820 |
ANKRD3 |
0.721 | -0.042 | 1 | 0.811 |
MLK2 |
0.720 | -0.083 | 2 | 0.811 |
MNK1 |
0.720 | -0.030 | -2 | 0.199 |
ATM |
0.720 | -0.015 | 1 | 0.674 |
CK1A |
0.719 | 0.238 | -3 | 0.508 |
RIPK1 |
0.719 | -0.023 | 1 | 0.788 |
NUAK1 |
0.718 | -0.056 | -3 | 0.666 |
NIM1 |
0.718 | -0.077 | 3 | 0.702 |
PRKD3 |
0.718 | -0.040 | -3 | 0.630 |
PKCA |
0.718 | -0.015 | 2 | 0.733 |
PAK3 |
0.718 | -0.077 | -2 | 0.197 |
JNK2 |
0.718 | 0.021 | 1 | 0.558 |
PKR |
0.717 | -0.009 | 1 | 0.827 |
DYRK4 |
0.717 | 0.019 | 1 | 0.572 |
MST3 |
0.717 | 0.091 | 2 | 0.848 |
CLK1 |
0.717 | -0.009 | -3 | 0.644 |
MEK1 |
0.717 | -0.040 | 2 | 0.838 |
ULK1 |
0.717 | -0.156 | -3 | 0.626 |
GSK3B |
0.716 | 0.067 | 4 | 0.472 |
PAK2 |
0.716 | -0.062 | -2 | 0.203 |
MLK4 |
0.716 | -0.005 | 2 | 0.720 |
CDK18 |
0.716 | -0.004 | 1 | 0.559 |
MNK2 |
0.715 | -0.073 | -2 | 0.185 |
JNK3 |
0.715 | 0.017 | 1 | 0.595 |
CDK8 |
0.715 | -0.051 | 1 | 0.594 |
MELK |
0.715 | -0.062 | -3 | 0.677 |
BRSK2 |
0.715 | -0.041 | -3 | 0.676 |
GAK |
0.714 | 0.185 | 1 | 0.847 |
PAK6 |
0.714 | -0.046 | -2 | 0.149 |
DAPK1 |
0.713 | 0.030 | -3 | 0.673 |
DCAMKL1 |
0.713 | -0.028 | -3 | 0.689 |
PKCZ |
0.713 | -0.045 | 2 | 0.765 |
WNK3 |
0.712 | -0.173 | 1 | 0.767 |
CDK7 |
0.712 | -0.045 | 1 | 0.617 |
PLK2 |
0.712 | 0.061 | -3 | 0.678 |
IRE1 |
0.712 | -0.059 | 1 | 0.778 |
CDK19 |
0.712 | -0.045 | 1 | 0.555 |
NEK9 |
0.711 | -0.182 | 2 | 0.817 |
TLK2 |
0.711 | -0.063 | 1 | 0.734 |
PKCH |
0.711 | -0.039 | 2 | 0.717 |
CHK1 |
0.711 | -0.091 | -3 | 0.695 |
CAMK1D |
0.711 | -0.011 | -3 | 0.583 |
DYRK1B |
0.710 | -0.010 | 1 | 0.621 |
DAPK3 |
0.710 | 0.008 | -3 | 0.688 |
SSTK |
0.710 | -0.012 | 4 | 0.737 |
MPSK1 |
0.710 | 0.109 | 1 | 0.775 |
P70S6K |
0.709 | -0.017 | -3 | 0.585 |
CDK17 |
0.709 | -0.010 | 1 | 0.514 |
DNAPK |
0.708 | -0.034 | 1 | 0.576 |
AKT1 |
0.708 | -0.021 | -3 | 0.614 |
TAO3 |
0.708 | 0.018 | 1 | 0.762 |
AKT3 |
0.708 | -0.001 | -3 | 0.550 |
TLK1 |
0.708 | 0.019 | -2 | 0.351 |
PRP4 |
0.708 | 0.014 | -3 | 0.686 |
SGK1 |
0.708 | 0.011 | -3 | 0.532 |
BRAF |
0.708 | -0.038 | -4 | 0.783 |
P38B |
0.708 | -0.019 | 1 | 0.567 |
SMMLCK |
0.707 | -0.037 | -3 | 0.674 |
P38G |
0.707 | -0.005 | 1 | 0.502 |
CDK2 |
0.707 | -0.020 | 1 | 0.691 |
PHKG1 |
0.706 | -0.082 | -3 | 0.701 |
P38A |
0.706 | -0.038 | 1 | 0.639 |
CDK3 |
0.706 | 0.005 | 1 | 0.533 |
GCK |
0.705 | 0.085 | 1 | 0.785 |
CDK10 |
0.705 | 0.006 | 1 | 0.594 |
CDK16 |
0.705 | -0.003 | 1 | 0.528 |
MEK5 |
0.704 | -0.061 | 2 | 0.811 |
CDK5 |
0.704 | -0.030 | 1 | 0.642 |
ZAK |
0.704 | -0.049 | 1 | 0.730 |
ERK1 |
0.704 | -0.021 | 1 | 0.553 |
DYRK3 |
0.703 | -0.022 | 1 | 0.668 |
MEKK2 |
0.703 | 0.004 | 2 | 0.789 |
CDK14 |
0.703 | -0.014 | 1 | 0.607 |
DYRK1A |
0.703 | -0.038 | 1 | 0.677 |
VRK2 |
0.703 | -0.200 | 1 | 0.817 |
PLK4 |
0.702 | -0.087 | 2 | 0.583 |
PERK |
0.702 | -0.064 | -2 | 0.319 |
PAK5 |
0.701 | -0.066 | -2 | 0.138 |
IRE2 |
0.701 | -0.101 | 2 | 0.699 |
JNK1 |
0.701 | 0.016 | 1 | 0.568 |
SNRK |
0.700 | -0.129 | 2 | 0.631 |
DCAMKL2 |
0.700 | -0.055 | -3 | 0.696 |
MEKK1 |
0.700 | -0.090 | 1 | 0.746 |
PAK4 |
0.700 | -0.054 | -2 | 0.143 |
CHAK1 |
0.700 | -0.134 | 2 | 0.729 |
PKCE |
0.700 | -0.011 | 2 | 0.727 |
MST2 |
0.699 | 0.009 | 1 | 0.769 |
ROCK2 |
0.699 | 0.013 | -3 | 0.677 |
HPK1 |
0.699 | 0.044 | 1 | 0.768 |
CDK13 |
0.699 | -0.070 | 1 | 0.591 |
SMG1 |
0.699 | -0.108 | 1 | 0.674 |
NEK11 |
0.699 | 0.008 | 1 | 0.754 |
ERK2 |
0.699 | -0.034 | 1 | 0.607 |
MAK |
0.698 | -0.002 | -2 | 0.178 |
HIPK3 |
0.698 | -0.035 | 1 | 0.647 |
CK1G2 |
0.698 | 0.242 | -3 | 0.539 |
MRCKA |
0.698 | -0.015 | -3 | 0.639 |
MAPKAPK5 |
0.698 | -0.122 | -3 | 0.571 |
DMPK1 |
0.697 | 0.028 | -3 | 0.662 |
TAK1 |
0.697 | 0.083 | 1 | 0.776 |
NEK2 |
0.697 | -0.173 | 2 | 0.789 |
PKCT |
0.696 | -0.068 | 2 | 0.724 |
CAMK1A |
0.696 | -0.025 | -3 | 0.562 |
NEK5 |
0.695 | -0.115 | 1 | 0.777 |
WNK4 |
0.695 | -0.111 | -2 | 0.246 |
PKCI |
0.695 | -0.068 | 2 | 0.733 |
P38D |
0.694 | -0.026 | 1 | 0.481 |
MRCKB |
0.694 | -0.020 | -3 | 0.625 |
CAMKK2 |
0.694 | -0.111 | -2 | 0.216 |
CDK12 |
0.693 | -0.063 | 1 | 0.561 |
CDK9 |
0.693 | -0.073 | 1 | 0.595 |
CAMKK1 |
0.692 | -0.133 | -2 | 0.236 |
LKB1 |
0.691 | -0.067 | -3 | 0.668 |
HRI |
0.691 | -0.174 | -2 | 0.276 |
SLK |
0.690 | -0.059 | -2 | 0.209 |
MST1 |
0.689 | -0.019 | 1 | 0.755 |
PINK1 |
0.689 | -0.191 | 1 | 0.805 |
TTBK1 |
0.689 | -0.044 | 2 | 0.615 |
YANK3 |
0.689 | 0.035 | 2 | 0.429 |
TAO2 |
0.689 | -0.090 | 2 | 0.838 |
NEK8 |
0.689 | -0.096 | 2 | 0.793 |
SBK |
0.688 | -0.023 | -3 | 0.499 |
IRAK4 |
0.688 | -0.120 | 1 | 0.765 |
KHS2 |
0.687 | 0.016 | 1 | 0.760 |
MOK |
0.687 | -0.011 | 1 | 0.683 |
MINK |
0.687 | -0.040 | 1 | 0.750 |
TNIK |
0.687 | -0.045 | 3 | 0.721 |
PDK1 |
0.687 | -0.079 | 1 | 0.761 |
CHK2 |
0.686 | -0.037 | -3 | 0.553 |
PHKG2 |
0.686 | -0.121 | -3 | 0.681 |
EEF2K |
0.686 | -0.048 | 3 | 0.699 |
CRIK |
0.686 | 0.020 | -3 | 0.606 |
LRRK2 |
0.685 | -0.090 | 2 | 0.822 |
CK1G3 |
0.684 | 0.184 | -3 | 0.469 |
PDHK3_TYR |
0.684 | 0.175 | 4 | 0.790 |
PBK |
0.684 | -0.004 | 1 | 0.758 |
STK33 |
0.683 | -0.072 | 2 | 0.617 |
PDHK4_TYR |
0.683 | 0.215 | 2 | 0.880 |
KHS1 |
0.683 | -0.030 | 1 | 0.737 |
ALPHAK3 |
0.682 | 0.100 | -1 | 0.692 |
BMPR2_TYR |
0.682 | 0.200 | -1 | 0.814 |
ROCK1 |
0.682 | -0.015 | -3 | 0.641 |
LOK |
0.682 | -0.100 | -2 | 0.197 |
PKN1 |
0.682 | -0.072 | -3 | 0.605 |
BUB1 |
0.681 | -0.032 | -5 | 0.729 |
MAP3K15 |
0.681 | -0.076 | 1 | 0.706 |
MAP2K6_TYR |
0.680 | 0.180 | -1 | 0.780 |
HGK |
0.679 | -0.108 | 3 | 0.710 |
HASPIN |
0.679 | 0.035 | -1 | 0.638 |
TTK |
0.679 | 0.003 | -2 | 0.301 |
ERK7 |
0.678 | -0.036 | 2 | 0.535 |
MEKK6 |
0.677 | -0.112 | 1 | 0.728 |
OSR1 |
0.677 | -0.015 | 2 | 0.796 |
IRAK1 |
0.677 | -0.191 | -1 | 0.598 |
NEK4 |
0.677 | -0.158 | 1 | 0.740 |
PKG1 |
0.677 | -0.086 | -2 | 0.112 |
PDHK1_TYR |
0.676 | 0.173 | -1 | 0.776 |
MAP2K4_TYR |
0.674 | 0.072 | -1 | 0.758 |
VRK1 |
0.674 | -0.127 | 2 | 0.802 |
NEK1 |
0.674 | -0.167 | 1 | 0.760 |
YSK1 |
0.672 | -0.104 | 2 | 0.795 |
CDK6 |
0.671 | -0.062 | 1 | 0.575 |
TESK1_TYR |
0.670 | 0.013 | 3 | 0.783 |
CDK4 |
0.668 | -0.072 | 1 | 0.551 |
MAP2K7_TYR |
0.665 | -0.069 | 2 | 0.842 |
MEK2 |
0.665 | -0.237 | 2 | 0.784 |
YANK2 |
0.665 | 0.034 | 2 | 0.447 |
SYK |
0.664 | 0.268 | -1 | 0.757 |
PKMYT1_TYR |
0.664 | -0.031 | 3 | 0.755 |
EPHA6 |
0.663 | 0.058 | -1 | 0.759 |
PTK2 |
0.662 | 0.191 | -1 | 0.800 |
RIPK2 |
0.662 | -0.203 | 1 | 0.683 |
BIKE |
0.662 | -0.015 | 1 | 0.728 |
MYO3A |
0.661 | -0.084 | 1 | 0.758 |
TXK |
0.660 | 0.113 | 1 | 0.855 |
MYO3B |
0.659 | -0.100 | 2 | 0.802 |
PINK1_TYR |
0.658 | -0.106 | 1 | 0.814 |
LIMK2_TYR |
0.657 | -0.091 | -3 | 0.726 |
ASK1 |
0.656 | -0.129 | 1 | 0.696 |
FGR |
0.655 | 0.057 | 1 | 0.821 |
EPHA4 |
0.654 | 0.036 | 2 | 0.796 |
FLT1 |
0.653 | 0.073 | -1 | 0.772 |
EPHB4 |
0.652 | -0.013 | -1 | 0.697 |
TAO1 |
0.652 | -0.136 | 1 | 0.668 |
FYN |
0.651 | 0.129 | -1 | 0.689 |
INSRR |
0.651 | 0.012 | 3 | 0.625 |
NEK3 |
0.650 | -0.232 | 1 | 0.682 |
LIMK1_TYR |
0.648 | -0.185 | 2 | 0.819 |
SRMS |
0.648 | 0.009 | 1 | 0.839 |
RET |
0.647 | -0.146 | 1 | 0.744 |
STLK3 |
0.647 | -0.128 | 1 | 0.694 |
YES1 |
0.645 | -0.028 | -1 | 0.659 |
AAK1 |
0.645 | 0.002 | 1 | 0.628 |
JAK3 |
0.645 | -0.049 | 1 | 0.723 |
FER |
0.644 | -0.046 | 1 | 0.836 |
BLK |
0.644 | 0.064 | -1 | 0.687 |
KDR |
0.644 | -0.026 | 3 | 0.639 |
MET |
0.643 | 0.054 | 3 | 0.658 |
ABL2 |
0.643 | -0.052 | -1 | 0.633 |
FGFR2 |
0.643 | -0.055 | 3 | 0.700 |
LCK |
0.643 | 0.036 | -1 | 0.688 |
DDR1 |
0.643 | -0.155 | 4 | 0.685 |
MST1R |
0.642 | -0.132 | 3 | 0.679 |
ZAP70 |
0.641 | 0.160 | -1 | 0.679 |
EPHB2 |
0.640 | -0.013 | -1 | 0.670 |
KIT |
0.640 | -0.044 | 3 | 0.667 |
ITK |
0.640 | -0.026 | -1 | 0.634 |
CSF1R |
0.640 | -0.105 | 3 | 0.658 |
EPHB1 |
0.639 | -0.058 | 1 | 0.810 |
TYK2 |
0.639 | -0.231 | 1 | 0.736 |
TNK2 |
0.639 | -0.076 | 3 | 0.642 |
ERBB2 |
0.638 | 0.008 | 1 | 0.738 |
HCK |
0.638 | -0.040 | -1 | 0.671 |
FGFR3 |
0.638 | -0.014 | 3 | 0.671 |
ABL1 |
0.638 | -0.075 | -1 | 0.613 |
EPHB3 |
0.637 | -0.061 | -1 | 0.670 |
TYRO3 |
0.636 | -0.176 | 3 | 0.655 |
ROS1 |
0.636 | -0.166 | 3 | 0.627 |
EGFR |
0.635 | 0.021 | 1 | 0.648 |
JAK2 |
0.635 | -0.206 | 1 | 0.720 |
ERBB4 |
0.635 | 0.094 | 1 | 0.689 |
EPHA7 |
0.634 | -0.037 | 2 | 0.787 |
BMX |
0.634 | -0.013 | -1 | 0.563 |
EPHA3 |
0.634 | -0.045 | 2 | 0.756 |
EPHA5 |
0.633 | 0.004 | 2 | 0.778 |
WEE1_TYR |
0.631 | -0.064 | -1 | 0.601 |
SRC |
0.631 | 0.037 | -1 | 0.649 |
EPHA8 |
0.631 | 0.004 | -1 | 0.692 |
MERTK |
0.630 | -0.095 | 3 | 0.667 |
NEK10_TYR |
0.630 | -0.165 | 1 | 0.633 |
FLT3 |
0.629 | -0.134 | 3 | 0.644 |
DDR2 |
0.629 | -0.081 | 3 | 0.627 |
TEK |
0.628 | -0.136 | 3 | 0.605 |
NTRK1 |
0.628 | -0.134 | -1 | 0.680 |
PDGFRB |
0.628 | -0.182 | 3 | 0.668 |
MATK |
0.628 | -0.042 | -1 | 0.584 |
FGFR1 |
0.627 | -0.142 | 3 | 0.649 |
FGFR4 |
0.627 | -0.022 | -1 | 0.644 |
FLT4 |
0.627 | -0.097 | 3 | 0.657 |
EPHA2 |
0.626 | -0.004 | -1 | 0.686 |
LYN |
0.626 | -0.035 | 3 | 0.597 |
TEC |
0.626 | -0.070 | -1 | 0.519 |
TNK1 |
0.624 | -0.185 | 3 | 0.646 |
PTK2B |
0.624 | -0.043 | -1 | 0.546 |
FRK |
0.623 | -0.053 | -1 | 0.664 |
TNNI3K_TYR |
0.623 | -0.149 | 1 | 0.719 |
AXL |
0.623 | -0.169 | 3 | 0.657 |
NTRK3 |
0.623 | -0.097 | -1 | 0.639 |
JAK1 |
0.622 | -0.161 | 1 | 0.667 |
INSR |
0.621 | -0.108 | 3 | 0.593 |
PTK6 |
0.621 | -0.180 | -1 | 0.552 |
BTK |
0.620 | -0.173 | -1 | 0.567 |
LTK |
0.619 | -0.164 | 3 | 0.632 |
ALK |
0.619 | -0.158 | 3 | 0.589 |
PDGFRA |
0.617 | -0.248 | 3 | 0.667 |
CSK |
0.615 | -0.115 | 2 | 0.780 |
EPHA1 |
0.615 | -0.163 | 3 | 0.616 |
NTRK2 |
0.615 | -0.191 | 3 | 0.641 |
IGF1R |
0.614 | -0.065 | 3 | 0.551 |
FES |
0.600 | -0.069 | -1 | 0.532 |
MUSK |
0.597 | -0.153 | 1 | 0.649 |