Motif 1163 (n=134)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0G2JKD1 | MUC21 | S590 | ochoa | Mucin 21, cell surface associated | None |
| A0A140T8X8 | MUC21 | S620 | ochoa | Mucin 21, cell surface associated | None |
| K7N7A8 | None | S442 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY (EC 3.4.19.12) | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo. {ECO:0000256|ARBA:ARBA00049627}.; FUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000256|RuleBase:RU367088}.; FUNCTION: Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000256|ARBA:ARBA00037630}. |
| O00220 | TNFRSF10A | S463 | ochoa | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9430227}. |
| O00264 | PGRMC1 | S190 | ochoa | Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA) | Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021). {ECO:0000250|UniProtKB:O55022, ECO:0000269|PubMed:25675345, ECO:0000269|PubMed:27599036, ECO:0000269|PubMed:30443021, ECO:0000303|PubMed:28396637}. |
| O14737 | PDCD5 | S119 | ochoa|psp | Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) | May function in the process of apoptosis. |
| O14920 | IKBKB | S750 | psp | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:17213322, PubMed:19716809). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylates STAT1 at 'Thr-749' which restricts interferon signaling and anti-inflammatory responses and promotes innate inflammatory responses (PubMed:38621137). IKBKB-mediated phosphorylation of STAT1 at 'Thr-749' promotes binding of STAT1 to the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). It also promotes binding of STAT1 to the IL12B promoter and activation of IL12B transcription (PubMed:32209697). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:32209697, ECO:0000269|PubMed:38621137, ECO:0000269|PubMed:9346484}. |
| O15084 | ANKRD28 | S1048 | ochoa | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) | Regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Involved in the PP6-mediated dephosphorylation of MOB1 and induced focal adhesion assembly during cell migration (PubMed:35512830). {ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651, ECO:0000269|PubMed:35512830}. |
| O43422 | THAP12 | S755 | ochoa | 52 kDa repressor of the inhibitor of the protein kinase (p52rIPK) (58 kDa interferon-induced protein kinase-interacting protein) (p58IPK-interacting protein) (Death-associated protein 4) (THAP domain-containing protein 0) (THAP domain-containing protein 12) | Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. |
| O60487 | MPZL2 | S208 | ochoa | Myelin protein zero-like protein 2 (Epithelial V-like antigen 1) | Mediates homophilic cell-cell adhesion. |
| O60669 | SLC16A7 | S472 | ochoa | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) | Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}. |
| O95104 | SCAF4 | S1141 | ochoa | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF8, also acts as a suppressor of transcriptional readthrough (PubMed:31104839). {ECO:0000269|PubMed:31104839}. |
| O95475 | SIX6 | S240 | ochoa | Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) | May be involved in eye development. |
| O95990 | FAM107A | S139 | ochoa | Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A) | Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580). {ECO:0000250|UniProtKB:Q78TU8, ECO:0000269|PubMed:10564580, ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}. |
| P01350 | GAST | S96 | psp | Gastrin [Cleaved into: Gastrin-71 (Gastrin component I); Gastrin-52 (G52); Big gastrin (Gastrin component II) (Gastrin-34) (G34); Gastrin (Gastrin component III) (Gastrin-17) (G17); Gastrin-14 (G14); Gastrin-6 (G6)] | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. |
| P04792 | HSPB1 | S199 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P04921 | GYPC | S122 | ochoa | Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236) | This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. |
| P07900 | HSP90AA1 | S726 | ochoa|psp | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P07910 | HNRNPC | S299 | ochoa|psp | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P08238 | HSP90AB1 | S718 | ochoa|psp | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P10451 | SPP1 | S308 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11388 | TOP2A | S1525 | ochoa|psp | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P14679 | TYR | S523 | psp | Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB) | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582). {ECO:0000250|UniProtKB:P11344, ECO:0000269|PubMed:28661582}. |
| P17096 | HMGA1 | S102 | ochoa|psp | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| P17987 | TCP1 | S551 | ochoa | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P18433 | PTPRA | S796 | ochoa | Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) | Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:P18052}. |
| P18858 | LIG1 | S913 | ochoa | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) | DNA ligase that seals nicks in double-stranded during DNA repair (PubMed:30395541). Also involved in DNA replication and DNA recombination. {ECO:0000269|PubMed:30395541}. |
| P19484 | TFEB | S469 | ochoa | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P19532 | TFE3 | S570 | ochoa | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) | Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:24448649). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:24448649, PubMed:31672913, PubMed:36608670). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:24448649, PubMed:31672913, PubMed:36608670). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:24448649). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (By similarity). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (By similarity). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:36608670, ECO:0000269|PubMed:37079666}. |
| P20290 | BTF3 | S201 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
| P20701 | ITGAL | S1165 | psp | Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) | Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:29100055, ECO:0000269|PubMed:38195629}. |
| P23469 | PTPRE | S694 | ochoa | Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) | Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). {ECO:0000250}.; FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). {ECO:0000250}. |
| P25101 | EDNRA | S421 | psp | Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| P25788 | PSMA3 | S250 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P29972 | AQP1 | S262 | ochoa | Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel) | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:16682607, ECO:0000269|PubMed:17012249, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:33028705, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:36949749, ECO:0000269|PubMed:8584435, ECO:0000269|PubMed:8703053}. |
| P30511 | HLA-F | S340 | ochoa | HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F) | Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464). {ECO:0000269|PubMed:23851683, ECO:0000269|PubMed:24018270, ECO:0000269|PubMed:26928464, ECO:0000269|PubMed:27455421, ECO:0000269|PubMed:28636952}. |
| P38432 | COIL | S571 | ochoa|psp | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P41743 | PRKCI | S591 | psp | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P46459 | NSF | S739 | ochoa | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
| P48681 | NES | S1615 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49407 | ARRB1 | S412 | ochoa|psp | Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) | Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as a signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (PubMed:23886940). {ECO:0000250, ECO:0000269|PubMed:12464600, ECO:0000269|PubMed:14711824, ECO:0000269|PubMed:15475570, ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:15671180, ECO:0000269|PubMed:15878855, ECO:0000269|PubMed:16144840, ECO:0000269|PubMed:16280323, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:16492667, ECO:0000269|PubMed:16709866, ECO:0000269|PubMed:18337459, ECO:0000269|PubMed:18419762, ECO:0000269|PubMed:19620252, ECO:0000269|PubMed:19643177, ECO:0000269|PubMed:22457824, ECO:0000269|PubMed:23341447, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:23886940}. |
| P49427 | CDC34 | S231 | psp | Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) | E2 ubiquitin-conjugating enzyme that accepts ubiquitin from an E1 ubiquitin-activating protein, and catalyzes its covalent attachment to other proteins by an E3 ubiquitin-protein ligase complex (PubMed:10329681, PubMed:17588522, PubMed:20061386, PubMed:38326650). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation (PubMed:10329681, PubMed:10918611, PubMed:17698585). Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1 (PubMed:10871850, PubMed:15652359, PubMed:19112177). Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation (PubMed:19126550). Also involved in the degradation of beta-catenin (PubMed:12037680). Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:11805320, PubMed:12060736). {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:10871850, ECO:0000269|PubMed:10918611, ECO:0000269|PubMed:11805320, ECO:0000269|PubMed:12037680, ECO:0000269|PubMed:12060736, ECO:0000269|PubMed:15652359, ECO:0000269|PubMed:17588522, ECO:0000269|PubMed:17698585, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:19126550, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:38326650}. |
| P49585 | PCYT1A | S362 | ochoa|psp | Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A) | Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. {ECO:0000269|PubMed:10480912, ECO:0000269|PubMed:30559292, ECO:0000269|PubMed:7918629}. |
| P53365 | ARFIP2 | S336 | ochoa | Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (POR1) | Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network (PubMed:26507660). May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660). Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site (PubMed:30917996, PubMed:31204568). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658). {ECO:0000269|PubMed:26296658, ECO:0000269|PubMed:26507660, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:31204568, ECO:0000269|PubMed:33773106}. |
| P54725 | RAD23A | S357 | ochoa | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; FUNCTION: (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. {ECO:0000269|PubMed:20614012}. |
| P78344 | EIF4G2 | S902 | ochoa|psp | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P78536 | ADAM17 | S819 | ochoa|psp | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481). Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:36078095, PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:28923481). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:24337742, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:28923481, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:9034191}. |
| P84098 | RPL19 | S189 | ochoa | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P98194 | ATP2C1 | S913 | ochoa | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) | ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:14632183, PubMed:20439740). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:10615129, PubMed:14632183, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}. |
| P98194 | ATP2C1 | S914 | ochoa | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) | ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:14632183, PubMed:20439740). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:10615129, PubMed:14632183, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}. |
| Q00534 | CDK6 | S321 | ochoa | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Q02763 | TEK | S1119 | ochoa|psp | Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) | Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1; SHC1 and TIE1. {ECO:0000269|PubMed:12816861, ECO:0000269|PubMed:14665640, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:18366015, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:20651738, ECO:0000269|PubMed:9204896}. |
| Q02790 | FKBP4 | S453 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q02952 | AKAP12 | S1777 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q13158 | FADD | S203 | psp | FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:23955153, PubMed:24025841, PubMed:7538907, PubMed:9184224). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:16762833, PubMed:19118384, PubMed:20935634, PubMed:7538907, PubMed:9184224). Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225, PubMed:24204270). {ECO:0000269|PubMed:16762833, ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:21109225, ECO:0000269|PubMed:23955153, ECO:0000269|PubMed:24025841, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:7538907, ECO:0000269|PubMed:9184224}. |
| Q13371 | PDCL | S296 | ochoa|psp | Phosducin-like protein (PHLP) | Acts as a positive regulator of hedgehog signaling and regulates ciliary function. {ECO:0000250|UniProtKB:Q9DBX2}.; FUNCTION: [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.; FUNCTION: [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin. |
| Q13509 | TUBB3 | S444 | psp | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). {ECO:0000269|PubMed:20074521, ECO:0000269|PubMed:28483977, ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| Q13541 | EIF4EBP1 | S112 | ochoa|psp | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22684010, ECO:0000269|PubMed:7935836}. |
| Q15269 | PWP2 | S913 | ochoa | Periodic tryptophan protein 2 homolog | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q15417 | CNN3 | S323 | ochoa | Calponin-3 (Calponin, acidic isoform) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q15651 | HMGN3 | S93 | ochoa | High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}. |
| Q16384 | SSX1 | S181 | ochoa | Protein SSX1 (Cancer/testis antigen 5.1) (CT5.1) (Synovial sarcoma, X breakpoint 1) | Could act as a modulator of transcription (PubMed:7539744). Plays a role in spermatogenesis (PubMed:36796361). {ECO:0000269|PubMed:36796361, ECO:0000269|PubMed:7539744}. |
| Q16385 | SSX2 | S181 | ochoa | Protein SSX2 (Cancer/testis antigen 5.2) (CT5.2) (Synovial sarcoma, X breakpoint 2) (Tumor antigen HOM-MEL-40) | Could act as a modulator of transcription. |
| Q56VL3 | OCIAD2 | S149 | ochoa | OCIA domain-containing protein 2 (Ovarian carcinoma immunoreactive antigen-like protein) | Has an essential role in the assembly of mitochondrial respiratory chain complex III (PubMed:35080992). Is also required for STAT3 activation and plays a role in cell migration (PubMed:29743632). {ECO:0000269|PubMed:29743632, ECO:0000269|PubMed:35080992}. |
| Q5HYI7 | MTX3 | S306 | ochoa | Metaxin-3 | Could function in transport of proteins into the mitochondrion. {ECO:0000250}. |
| Q5JTJ3 | COA6 | S119 | ochoa | Cytochrome c oxidase assembly factor 6 homolog | Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. {ECO:0000269|PubMed:24549041, ECO:0000269|PubMed:25959673, ECO:0000269|PubMed:26160915}. |
| Q5SSG8 | MUC21 | S560 | ochoa | Mucin-21 (MUC-21) (Epiglycanin) | None |
| Q5VZL5 | ZMYM4 | S1542 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q6P444 | MTFR2 | S379 | ochoa | Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) | May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). {ECO:0000250}. |
| Q6PD74 | AAGAB | S310 | ochoa | Alpha- and gamma-adaptin-binding protein p34 | May be involved in endocytic recycling of growth factor receptors such as EGFR. {ECO:0000269|PubMed:23064416}. |
| Q6UWZ7 | ABRAXAS1 | S404 | ochoa|psp | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538, ECO:0000269|PubMed:26778126}. |
| Q712K3 | UBE2R2 | S233 | psp | Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2) | E2 ubiquitin-conjugating enzyme that accepts ubiquitin from an E1 ubiquitin-activating protein, and catalyzes its covalent attachment to other proteins by an E3 ubiquitin-protein ligase complex (PubMed:12037680, PubMed:20061386, PubMed:38326650). In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination (PubMed:12037680, PubMed:20061386, PubMed:38326650). Works in collaboration with various Cul1-RING and Cul2-RING E3 ligase complexes (PubMed:38326650). May be involved in degradation of katenin (PubMed:12037680). {ECO:0000269|PubMed:12037680, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:38326650}. |
| Q7L1Q6 | BZW1 | S413 | ochoa | eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) | Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015). {ECO:0000269|PubMed:11524015, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}. |
| Q7RTT3 | SSX9P | S181 | ochoa | Putative protein SSX9 | Could act as a modulator of transcription. |
| Q7RTT5 | SSX7 | S181 | ochoa | Protein SSX7 | Could act as a modulator of transcription. |
| Q7Z3F1 | GPR155 | S865 | ochoa | Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22) | Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (PubMed:36007018, PubMed:39358511). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (PubMed:36007018). Binds indole-3-acetic acid and may play a role in tryptophan metabolism (PubMed:39358511). {ECO:0000269|PubMed:36007018, ECO:0000269|PubMed:39358511}. |
| Q7Z7L8 | C11orf96 | S429 | ochoa | Uncharacterized protein C11orf96 (Protein Ag2 homolog) | None |
| Q86UW7 | CADPS2 | S1290 | ochoa | Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2) | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). {ECO:0000250}. |
| Q8IVL1 | NAV2 | S2482 | ochoa | Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) | Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}. |
| Q8IWU2 | LMTK2 | S1497 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8N370 | SLC43A2 | S563 | ochoa | Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2) | Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:15659399, PubMed:30379325). The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:15659399). {ECO:0000269|PubMed:15659399, ECO:0000269|PubMed:30379325}. |
| Q8N9N8 | EIF1AD | S159 | ochoa | Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) (Haponin) | Plays a role into cellular response to oxidative stress. Decreases cell proliferation. {ECO:0000269|PubMed:20644585, ECO:0000269|PubMed:22095125}. |
| Q8N9Q2 | SREK1IP1 | S149 | ochoa | Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP) | Possible splicing regulator involved in the control of cellular survival. |
| Q8NFP7 | NUDT10 | S158 | ochoa | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (DIPP-3-alpha) (DIPP3-alpha) (hDIPP3alpha) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 10) (Nudix motif 10) (hAps2) | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:12105228}. |
| Q8NHQ9 | DDX55 | S594 | ochoa | ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55) | Probable ATP-binding RNA helicase. Has ATPase activity and is involved in the maturation of precursor large subunit rRNAs (PubMed:33048000). {ECO:0000269|PubMed:33048000}. |
| Q8TBF4 | ZCRB1 | S210 | ochoa | Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) (U11/U12-31K) | None |
| Q8TE77 | SSH3 | S653 | ochoa | Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L) | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}. |
| Q8TEA8 | DTD1 | S204 | ochoa|psp | D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) | Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}. |
| Q8WXA9 | SREK1 | S502 | ochoa | Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508) | Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity). {ECO:0000250}. |
| Q8WYL5 | SSH1 | S1044 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q96EQ0 | SGTB | S298 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250}. |
| Q96EQ0 | SGTB | S299 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250}. |
| Q96F63 | CCDC97 | S337 | ochoa | Coiled-coil domain-containing protein 97 | May play a role pre-mRNA splicing through the association with the splicing factor SF3B complex which is involved in branch-site recognition. {ECO:0000269|PubMed:26344197}. |
| Q96G61 | NUDT11 | S158 | ochoa | Diphosphoinositol polyphosphate phosphohydrolase 3-beta (DIPP-3-beta) (DIPP3-beta) (hDIPP3beta) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta) (Diadenosine hexaphosphate hydrolase (AMP-forming)) (EC 3.6.1.60) (Nucleoside diphosphate-linked moiety X motif 11) (Nudix motif 11) (hAps1) | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:12105228}. |
| Q96K17 | BTF3L4 | S153 | ochoa | Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) | None |
| Q96RQ3 | MCCC1 | S719 | ochoa | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) | Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195, ECO:0000269|PubMed:32561715}. |
| Q99523 | SORT1 | S825 | ochoa|psp | Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3) | Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366, ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608, ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763, ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396, ECO:0000269|PubMed:15987945, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}. |
| Q99608 | NDN | S316 | ochoa | Necdin | Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity). {ECO:0000250}. |
| Q99909 | SSX3 | S181 | ochoa | Protein SSX3 (Cancer/testis antigen 5.3) (CT5.3) | Could act as a modulator of transcription. |
| Q9BRK5 | SDF4 | S357 | ochoa | 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. {ECO:0000250}.; FUNCTION: Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini. |
| Q9BRP0 | OVOL2 | S269 | ochoa | Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339) | Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (By similarity). Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos (By similarity). Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity (By similarity). {ECO:0000250|UniProtKB:Q8CIV7, ECO:0000269|PubMed:19700410}. |
| Q9BRX2 | PELO | S380 | ochoa | Protein pelota homolog (hPelota) (Protein Dom34 homolog) | Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27543824, PubMed:27863242). In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27543824, PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). {ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:23667253, ECO:0000269|PubMed:27543824, ECO:0000269|PubMed:27863242, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:32006463}. |
| Q9BY89 | KIAA1671 | S1800 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BZC7 | ABCA2 | S2428 | ochoa | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}. |
| Q9H246 | C1orf21 | S115 | ochoa | Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) | None |
| Q9NRG0 | CHRAC1 | S124 | ochoa | Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) | Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371). {ECO:0000269|PubMed:14759371}. |
| Q9NRZ9 | HELLS | S832 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NRZ9 | HELLS | S833 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NUV7 | SPTLC3 | S547 | ochoa | Serine palmitoyltransferase 3 (EC 2.3.1.50) (Long chain base biosynthesis protein 2b) (LCB2b) (Long chain base biosynthesis protein 3) (LCB 3) (Serine-palmitoyl-CoA transferase 3) (SPT 3) | Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851, PubMed:19648650). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851, PubMed:19648650). {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:19648650}. |
| Q9NVA4 | TMEM184C | S432 | ochoa | Transmembrane protein 184C (Transmembrane protein 34) | Possible tumor suppressor which may play a role in cell growth. {ECO:0000269|PubMed:17072649}. |
| Q9NVR0 | KLHL11 | S703 | ochoa | Kelch-like protein 11 | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. {ECO:0000250}. |
| Q9P2K3 | RCOR3 | S490 | ochoa | REST corepressor 3 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q9P2M4 | TBC1D14 | S688 | ochoa | TBC1 domain family member 14 | Plays a role in the regulation of starvation-induced autophagosome formation (PubMed:22613832). Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. {ECO:0000269|PubMed:22613832, ECO:0000269|PubMed:26711178}. |
| Q9UBN6 | TNFRSF10D | S381 | ochoa | Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264) | Receptor for the cytotoxic ligand TRAIL (PubMed:9430226). Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed:9537512). Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway (PubMed:9382840, PubMed:9430226). {ECO:0000269|PubMed:9382840, ECO:0000269|PubMed:9430226, ECO:0000269|PubMed:9537512}. |
| Q9UD71 | PPP1R1B | S198 | ochoa | Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) | Inhibitor of protein-phosphatase 1. |
| Q9UI30 | TRMT112 | S119 | ochoa | Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) | Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:18539146, PubMed:20308323, PubMed:25851604, PubMed:31061526, PubMed:31328227, PubMed:31636962, PubMed:37283053). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146, PubMed:31061526, PubMed:31636962). The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) (PubMed:31061526). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (PubMed:34669960, PubMed:37283053). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:33428944, PubMed:35033535, PubMed:37283053). {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:31061526, ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:31636962, ECO:0000269|PubMed:33428944, ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:37283053}. |
| Q9UJV3 | MID2 | S729 | ochoa | Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1) | E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954). {ECO:0000269|PubMed:35266954, ECO:0000303|PubMed:24115387}. |
| Q9UKD2 | MRTO4 | S233 | psp | mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4) | Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. {ECO:0000269|PubMed:20083226}. |
| Q9UPU7 | TBC1D2B | S957 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9Y266 | NUDC | S326 | psp | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857). {ECO:0000250|UniProtKB:O35685, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857, ECO:0000269|PubMed:25789526}. |
| Q9Y3A3 | MOB4 | S218 | ochoa | MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3) | Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:33633399}. |
| Q9Y6E2 | BZW2 | S412 | ochoa | eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2) | Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). {ECO:0000269|PubMed:21745818, ECO:0000269|PubMed:28981728, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}. |
| Q9Y6E2 | BZW2 | S414 | ochoa | eIF5-mimic protein 1 (Basic leucine zipper and W2 domain-containing protein 2) | Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). {ECO:0000269|PubMed:21745818, ECO:0000269|PubMed:28981728, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}. |
| S4R3N1 | HSPE1-MOB4 | S254 | ochoa | 10 kDa heat shock protein, mitochondrial (10 kDa chaperonin) (Chaperonin 10) (MOB-like protein phocein) (Mob1 homolog 3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3) | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. {ECO:0000256|ARBA:ARBA00046093}.; FUNCTION: Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. {ECO:0000256|ARBA:ARBA00044741}. |
| O75347 | TBCA | S103 | Sugiyama | Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) | Tubulin-folding protein; involved in the early step of the tubulin folding pathway. |
| P19784 | CSNK2A2 | S344 | Sugiyama | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:30898438). Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection (PubMed:11704824, PubMed:16193064, PubMed:30898438). May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response (PubMed:12631575, PubMed:19387551, PubMed:19387552). During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation (PubMed:11239457). Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites (PubMed:20545769, PubMed:21482717, PubMed:22325354, PubMed:26811421, PubMed:30898438, PubMed:35597237). Can also negatively regulate apoptosis (PubMed:19387551, PubMed:19387552). Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (PubMed:12631575, PubMed:19387551, PubMed:19387552). Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV (PubMed:12631575, PubMed:19387551, PubMed:19387552). Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB (PubMed:12631575, PubMed:19387551, PubMed:19387552). Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function (PubMed:19387550). Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1 (PubMed:19387549). Acts as an ectokinase that phosphorylates several extracellular proteins (PubMed:12631575, PubMed:19387551, PubMed:19387552). During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV (PubMed:12631575, PubMed:19387551, PubMed:19387552). May phosphorylate histone H2A on 'Ser-1' (PubMed:38334665). {ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824, ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21482717, ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:38334665, ECO:0000303|PubMed:12631575, ECO:0000303|PubMed:19387549, ECO:0000303|PubMed:19387550, ECO:0000303|PubMed:19387551, ECO:0000303|PubMed:19387552}. |
| Q16719 | KYNU | S460 | Sugiyama | Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000269|PubMed:11985583, ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876, ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}. |
| Q9NPD3 | EXOSC4 | S240 | Sugiyama | Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. {ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:21255825}. |
| P13612 | ITGA4 | S1027 | ELM | Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:35802072}. |
| O14958 | CASQ2 | S393 | PSP | Calsequestrin-2 (Calsequestrin, cardiac muscle isoform) | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16908766, ECO:0000269|PubMed:17881003, ECO:0000269|PubMed:18399795, ECO:0000269|PubMed:21416293}. |
| Q96DB5 | RMDN1 | S309 | Sugiyama | Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B) | None |
| P31327 | CPS1 | S1495 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| Q16816 | PHKG1 | S381 | Sugiyama | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}. |
| Q6NVY1 | HIBCH | S381 | Sugiyama | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H) | Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000269|PubMed:8824301}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 7.295172e-10 | 9.137 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 2.705107e-05 | 4.568 |
| R-HSA-75158 | TRAIL signaling | 6.274462e-05 | 4.202 |
| R-HSA-3371568 | Attenuation phase | 8.545601e-05 | 4.068 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.463143e-05 | 4.127 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.437959e-04 | 3.613 |
| R-HSA-3371511 | HSF1 activation | 7.368334e-04 | 3.133 |
| R-HSA-3371378 | Regulation by c-FLIP | 4.813170e-03 | 2.318 |
| R-HSA-69416 | Dimerization of procaspase-8 | 4.813170e-03 | 2.318 |
| R-HSA-5218900 | CASP8 activity is inhibited | 5.693603e-03 | 2.245 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.690347e-03 | 2.245 |
| R-HSA-391251 | Protein folding | 2.745180e-03 | 2.561 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 4.272474e-03 | 2.369 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 5.899875e-03 | 2.229 |
| R-HSA-73887 | Death Receptor Signaling | 5.578933e-03 | 2.253 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 4.001924e-03 | 2.398 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 4.813170e-03 | 2.318 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 5.693603e-03 | 2.245 |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | 5.693603e-03 | 2.245 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.720860e-03 | 2.429 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 6.763840e-03 | 2.170 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 6.641897e-03 | 2.178 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 6.791941e-03 | 2.168 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 7.656746e-03 | 2.116 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 7.699190e-03 | 2.114 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 7.704920e-03 | 2.113 |
| R-HSA-3371556 | Cellular response to heat stress | 8.765095e-03 | 2.057 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 8.707236e-03 | 2.060 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 9.238889e-03 | 2.034 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 9.880964e-03 | 2.005 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.258535e-02 | 1.900 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.368478e-02 | 1.864 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.368478e-02 | 1.864 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.507249e-02 | 1.822 |
| R-HSA-9630794 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4... | 2.737958e-02 | 1.563 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 2.737958e-02 | 1.563 |
| R-HSA-9632700 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding... | 2.737958e-02 | 1.563 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 2.737958e-02 | 1.563 |
| R-HSA-9916722 | 3-hydroxyisobutyryl-CoA hydrolase deficiency | 2.737958e-02 | 1.563 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 3.633961e-02 | 1.440 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 3.633961e-02 | 1.440 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 3.633961e-02 | 1.440 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 3.633961e-02 | 1.440 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 3.633961e-02 | 1.440 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 3.633961e-02 | 1.440 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 3.633961e-02 | 1.440 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 3.633961e-02 | 1.440 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 3.633961e-02 | 1.440 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 3.633961e-02 | 1.440 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 3.633961e-02 | 1.440 |
| R-HSA-9909438 | 3-Methylcrotonyl-CoA carboxylase deficiency | 4.521764e-02 | 1.345 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 7.992463e-02 | 1.097 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.133782e-01 | 0.945 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.003015e-02 | 1.522 |
| R-HSA-429947 | Deadenylation of mRNA | 3.194611e-02 | 1.496 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.194611e-02 | 1.496 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.376728e-01 | 0.861 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.376728e-01 | 0.861 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.456232e-01 | 0.837 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.661561e-02 | 1.331 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 1.690401e-01 | 0.772 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 1.690401e-01 | 0.772 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 1.767031e-01 | 0.753 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 1.842960e-01 | 0.734 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 1.842960e-01 | 0.734 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 1.842960e-01 | 0.734 |
| R-HSA-210993 | Tie2 Signaling | 1.918193e-01 | 0.717 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 2.139782e-01 | 0.670 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 2.139782e-01 | 0.670 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 2.355334e-01 | 0.628 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.251689e-01 | 0.903 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 3.096647e-01 | 0.509 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.096647e-01 | 0.509 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.265010e-01 | 0.645 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.366979e-01 | 0.626 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.401028e-01 | 0.620 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.049091e-01 | 0.516 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.184771e-01 | 0.497 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.184771e-01 | 0.497 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.565015e-01 | 0.591 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.741528e-01 | 0.759 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.571576e-01 | 0.590 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.160388e-01 | 0.500 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.571576e-01 | 0.590 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 1.296490e-01 | 0.887 |
| R-HSA-162592 | Integration of provirus | 1.296490e-01 | 0.887 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.553130e-01 | 0.593 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 5.401442e-02 | 1.267 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 8.840374e-02 | 1.054 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.285629e-02 | 1.641 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.215510e-01 | 0.915 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 2.139782e-01 | 0.670 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.204335e-01 | 0.919 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.204335e-01 | 0.919 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.049091e-01 | 0.516 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 3.063718e-01 | 0.514 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.957831e-02 | 1.708 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 1.730624e-01 | 0.762 |
| R-HSA-75157 | FasL/ CD95L signaling | 4.521764e-02 | 1.345 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 7.136719e-02 | 1.147 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.095876e-01 | 0.679 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.083061e-01 | 0.511 |
| R-HSA-180024 | DARPP-32 events | 2.768981e-01 | 0.558 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 7.352710e-02 | 1.134 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.100668e-01 | 0.958 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 1.690401e-01 | 0.772 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.342403e-02 | 1.198 |
| R-HSA-9930044 | Nuclear RNA decay | 3.032315e-01 | 0.518 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 3.591774e-02 | 1.445 |
| R-HSA-9630750 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects | 2.737958e-02 | 1.563 |
| R-HSA-9632693 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects | 2.737958e-02 | 1.563 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 5.401442e-02 | 1.267 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 7.136719e-02 | 1.147 |
| R-HSA-192905 | vRNP Assembly | 1.215510e-01 | 0.915 |
| R-HSA-209560 | NF-kB is activated and signals survival | 1.296490e-01 | 0.887 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 1.376728e-01 | 0.861 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.456232e-01 | 0.837 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.456232e-01 | 0.837 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.613062e-01 | 0.792 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.842960e-01 | 0.734 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.483407e-02 | 1.605 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 1.918193e-01 | 0.717 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.212295e-01 | 0.655 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 2.425872e-01 | 0.615 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 2.901861e-01 | 0.537 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.599111e-01 | 0.796 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.267189e-01 | 0.897 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.009992e-01 | 0.996 |
| R-HSA-68877 | Mitotic Prometaphase | 1.347948e-01 | 0.870 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.696750e-01 | 0.770 |
| R-HSA-203615 | eNOS activation | 3.160388e-01 | 0.500 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 2.835727e-01 | 0.547 |
| R-HSA-9646399 | Aggrephagy | 7.091056e-02 | 1.149 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.041718e-01 | 0.982 |
| R-HSA-166208 | mTORC1-mediated signalling | 2.816214e-02 | 1.550 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.380908e-01 | 0.623 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.605723e-01 | 0.584 |
| R-HSA-72766 | Translation | 2.390221e-01 | 0.622 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.947015e-01 | 0.531 |
| R-HSA-5617833 | Cilium Assembly | 3.053078e-01 | 0.515 |
| R-HSA-9630747 | Diseases of Cellular Senescence | 3.633961e-02 | 1.440 |
| R-HSA-9675132 | Diseases of cellular response to stress | 3.633961e-02 | 1.440 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 7.992463e-02 | 1.097 |
| R-HSA-164843 | 2-LTR circle formation | 1.133782e-01 | 0.945 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.296490e-01 | 0.887 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.613062e-01 | 0.792 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.918193e-01 | 0.717 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 1.918193e-01 | 0.717 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 7.352710e-02 | 1.134 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.992737e-01 | 0.701 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 1.992737e-01 | 0.701 |
| R-HSA-6807004 | Negative regulation of MET activity | 2.066598e-01 | 0.685 |
| R-HSA-420029 | Tight junction interactions | 2.495764e-01 | 0.603 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 2.701618e-01 | 0.568 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.835727e-01 | 0.547 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 2.967389e-01 | 0.528 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 3.223545e-01 | 0.492 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 3.223545e-01 | 0.492 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.605723e-01 | 0.584 |
| R-HSA-72312 | rRNA processing | 2.060456e-01 | 0.686 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.565015e-01 | 0.591 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.425872e-01 | 0.615 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.296490e-01 | 0.887 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 3.312973e-02 | 1.480 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.457415e-02 | 1.610 |
| R-HSA-5662702 | Melanin biosynthesis | 2.066598e-01 | 0.685 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 3.003015e-02 | 1.522 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 1.918193e-01 | 0.717 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.631541e-01 | 0.787 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 1.902560e-01 | 0.721 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.776480e-01 | 0.557 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 8.840374e-02 | 1.054 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 8.840374e-02 | 1.054 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.051298e-01 | 0.978 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 1.296490e-01 | 0.887 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.296490e-01 | 0.887 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 1.376728e-01 | 0.861 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 1.376728e-01 | 0.861 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.376728e-01 | 0.861 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 1.535008e-01 | 0.814 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.613062e-01 | 0.792 |
| R-HSA-432047 | Passive transport by Aquaporins | 1.767031e-01 | 0.753 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 9.266067e-02 | 1.033 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.495764e-01 | 0.603 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.407308e-01 | 0.852 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 2.835727e-01 | 0.547 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.901861e-01 | 0.537 |
| R-HSA-216083 | Integrin cell surface interactions | 4.635248e-02 | 1.334 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.768981e-01 | 0.558 |
| R-HSA-196780 | Biotin transport and metabolism | 1.613062e-01 | 0.792 |
| R-HSA-5635838 | Activation of SMO | 1.690401e-01 | 0.772 |
| R-HSA-844456 | The NLRP3 inflammasome | 1.992737e-01 | 0.701 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.096647e-01 | 0.509 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.223545e-01 | 0.492 |
| R-HSA-69275 | G2/M Transition | 1.235480e-01 | 0.908 |
| R-HSA-8953854 | Metabolism of RNA | 2.698637e-01 | 0.569 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.267189e-01 | 0.897 |
| R-HSA-202424 | Downstream TCR signaling | 6.496162e-02 | 1.187 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.136719e-02 | 1.147 |
| R-HSA-5362798 | Release of Hh-Np from the secreting cell | 7.136719e-02 | 1.147 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.136719e-02 | 1.147 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.051298e-01 | 0.978 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 1.690401e-01 | 0.772 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.066598e-01 | 0.685 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 2.633631e-01 | 0.579 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.701618e-01 | 0.568 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.967389e-01 | 0.528 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.032315e-01 | 0.518 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 3.096647e-01 | 0.509 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 3.160388e-01 | 0.500 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 3.160388e-01 | 0.500 |
| R-HSA-169911 | Regulation of Apoptosis | 3.223545e-01 | 0.492 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.116999e-01 | 0.506 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.116999e-01 | 0.506 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.947015e-01 | 0.531 |
| R-HSA-75893 | TNF signaling | 2.207871e-02 | 1.656 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.631541e-01 | 0.787 |
| R-HSA-190861 | Gap junction assembly | 3.160388e-01 | 0.500 |
| R-HSA-5610787 | Hedgehog 'off' state | 2.742336e-01 | 0.562 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 3.591774e-02 | 1.445 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.918193e-01 | 0.717 |
| R-HSA-1369062 | ABC transporters in lipid homeostasis | 2.355334e-01 | 0.628 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.972718e-01 | 0.705 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 8.705544e-02 | 1.060 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 8.984494e-02 | 1.047 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 1.691078e-02 | 1.772 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 7.136719e-02 | 1.147 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 1.051298e-01 | 0.978 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.285629e-02 | 1.641 |
| R-HSA-5689877 | Josephin domain DUBs | 1.133782e-01 | 0.945 |
| R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.376728e-01 | 0.861 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.376728e-01 | 0.861 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.376728e-01 | 0.861 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 1.613062e-01 | 0.792 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.842960e-01 | 0.734 |
| R-HSA-5689901 | Metalloprotease DUBs | 2.565015e-01 | 0.591 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.223545e-01 | 0.492 |
| R-HSA-1280218 | Adaptive Immune System | 2.844094e-01 | 0.546 |
| R-HSA-9612973 | Autophagy | 7.914670e-02 | 1.102 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.163385e-01 | 0.665 |
| R-HSA-68886 | M Phase | 3.176928e-01 | 0.498 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.703892e-02 | 1.328 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 1.100668e-01 | 0.958 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.091018e-01 | 0.680 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.228004e-02 | 1.206 |
| R-HSA-5358351 | Signaling by Hedgehog | 5.676959e-02 | 1.246 |
| R-HSA-1640170 | Cell Cycle | 3.890698e-02 | 1.410 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.133782e-01 | 0.945 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.591774e-02 | 1.445 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.613062e-01 | 0.792 |
| R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 1.992737e-01 | 0.701 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.633631e-01 | 0.579 |
| R-HSA-622312 | Inflammasomes | 2.701618e-01 | 0.568 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 2.701618e-01 | 0.568 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.835727e-01 | 0.547 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.032315e-01 | 0.518 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.810616e-01 | 0.551 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.688481e-02 | 1.175 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 1.041718e-01 | 0.982 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.786813e-02 | 1.109 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.209354e-01 | 0.494 |
| R-HSA-9839373 | Signaling by TGFBR3 | 8.984494e-02 | 1.047 |
| R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 1.992737e-01 | 0.701 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.495764e-01 | 0.603 |
| R-HSA-9839394 | TGFBR3 expression | 2.495764e-01 | 0.603 |
| R-HSA-70635 | Urea cycle | 2.565015e-01 | 0.591 |
| R-HSA-9663891 | Selective autophagy | 6.190369e-02 | 1.208 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 2.835727e-01 | 0.547 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 1.041718e-01 | 0.982 |
| R-HSA-1483191 | Synthesis of PC | 9.266067e-02 | 1.033 |
| R-HSA-5218859 | Regulated Necrosis | 3.415916e-02 | 1.466 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.842960e-01 | 0.734 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 1.992737e-01 | 0.701 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.032315e-01 | 0.518 |
| R-HSA-382556 | ABC-family proteins mediated transport | 2.742336e-01 | 0.562 |
| R-HSA-69239 | Synthesis of DNA | 3.015092e-01 | 0.521 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.438919e-01 | 0.842 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.664088e-01 | 0.779 |
| R-HSA-180786 | Extension of Telomeres | 1.282469e-01 | 0.892 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.984618e-01 | 0.702 |
| R-HSA-165159 | MTOR signalling | 7.885161e-02 | 1.103 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.664088e-01 | 0.779 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.009097e-01 | 0.996 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 1.133782e-01 | 0.945 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.842960e-01 | 0.734 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.565015e-01 | 0.591 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.297680e-02 | 1.081 |
| R-HSA-5683057 | MAPK family signaling cascades | 2.537331e-01 | 0.596 |
| R-HSA-202403 | TCR signaling | 1.047781e-01 | 0.980 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.992737e-01 | 0.701 |
| R-HSA-445144 | Signal transduction by L1 | 2.066598e-01 | 0.685 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.139782e-01 | 0.670 |
| R-HSA-381042 | PERK regulates gene expression | 3.223545e-01 | 0.492 |
| R-HSA-157579 | Telomere Maintenance | 2.639876e-01 | 0.578 |
| R-HSA-8939211 | ESR-mediated signaling | 2.156430e-01 | 0.666 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 3.223545e-01 | 0.492 |
| R-HSA-2262752 | Cellular responses to stress | 1.017544e-01 | 0.992 |
| R-HSA-5357801 | Programmed Cell Death | 1.567324e-01 | 0.805 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.402631e-02 | 1.131 |
| R-HSA-5688426 | Deubiquitination | 2.511341e-01 | 0.600 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.828437e-01 | 0.738 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.776480e-01 | 0.557 |
| R-HSA-1538133 | G0 and Early G1 | 4.887928e-02 | 1.311 |
| R-HSA-1632852 | Macroautophagy | 1.810063e-01 | 0.742 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.284144e-01 | 0.641 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.096647e-01 | 0.509 |
| R-HSA-109581 | Apoptosis | 2.332081e-01 | 0.632 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 2.495764e-01 | 0.603 |
| R-HSA-69190 | DNA strand elongation | 2.967389e-01 | 0.528 |
| R-HSA-9909396 | Circadian clock | 1.584671e-01 | 0.800 |
| R-HSA-913531 | Interferon Signaling | 1.730624e-01 | 0.762 |
| R-HSA-8852135 | Protein ubiquitination | 4.249560e-02 | 1.372 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.795368e-01 | 0.746 |
| R-HSA-5358508 | Mismatch Repair | 1.918193e-01 | 0.717 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 3.160388e-01 | 0.500 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.184771e-01 | 0.497 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.565015e-01 | 0.591 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.160388e-01 | 0.500 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.166213e-02 | 1.145 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.166213e-02 | 1.145 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 2.565015e-01 | 0.591 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.223545e-01 | 0.492 |
| R-HSA-422475 | Axon guidance | 1.556598e-01 | 0.808 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 2.633631e-01 | 0.579 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.223545e-01 | 0.492 |
| R-HSA-9833482 | PKR-mediated signaling | 1.961571e-01 | 0.707 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.129604e-01 | 0.672 |
| R-HSA-373755 | Semaphorin interactions | 1.407308e-01 | 0.852 |
| R-HSA-9824446 | Viral Infection Pathways | 2.652888e-01 | 0.576 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.456232e-01 | 0.837 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.194572e-02 | 1.659 |
| R-HSA-9675108 | Nervous system development | 1.969762e-01 | 0.706 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 1.842960e-01 | 0.734 |
| R-HSA-5205647 | Mitophagy | 3.160388e-01 | 0.500 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.067228e-01 | 0.685 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.331629e-01 | 0.876 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 7.660977e-02 | 1.116 |
| R-HSA-177929 | Signaling by EGFR | 1.190687e-01 | 0.924 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.718852e-01 | 0.765 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.535008e-01 | 0.814 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.572037e-01 | 0.590 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.376193e-01 | 0.861 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 1.992737e-01 | 0.701 |
| R-HSA-982772 | Growth hormone receptor signaling | 2.355334e-01 | 0.628 |
| R-HSA-449147 | Signaling by Interleukins | 2.499943e-01 | 0.602 |
| R-HSA-157118 | Signaling by NOTCH | 2.214605e-01 | 0.655 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.470679e-01 | 0.832 |
| R-HSA-9679506 | SARS-CoV Infections | 2.855184e-01 | 0.544 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.664088e-01 | 0.779 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.952034e-01 | 0.530 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.828437e-01 | 0.738 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.071083e-01 | 0.970 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.696262e-01 | 0.771 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.231092e-01 | 0.651 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.252390e-01 | 0.488 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.286122e-01 | 0.483 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 3.286122e-01 | 0.483 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.305118e-01 | 0.481 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.348125e-01 | 0.475 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.348125e-01 | 0.475 |
| R-HSA-4641258 | Degradation of DVL | 3.348125e-01 | 0.475 |
| R-HSA-4641257 | Degradation of AXIN | 3.348125e-01 | 0.475 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 3.348125e-01 | 0.475 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.353493e-01 | 0.475 |
| R-HSA-909733 | Interferon alpha/beta signaling | 3.353493e-01 | 0.475 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.355531e-01 | 0.474 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.355543e-01 | 0.474 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.380750e-01 | 0.471 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 3.380750e-01 | 0.471 |
| R-HSA-376176 | Signaling by ROBO receptors | 3.380750e-01 | 0.471 |
| R-HSA-373760 | L1CAM interactions | 3.387099e-01 | 0.470 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 3.409560e-01 | 0.467 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.470430e-01 | 0.460 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.470430e-01 | 0.460 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.470430e-01 | 0.460 |
| R-HSA-69541 | Stabilization of p53 | 3.470430e-01 | 0.460 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 3.530743e-01 | 0.452 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.530743e-01 | 0.452 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.530743e-01 | 0.452 |
| R-HSA-5260271 | Diseases of Immune System | 3.530743e-01 | 0.452 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 3.530743e-01 | 0.452 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 3.530743e-01 | 0.452 |
| R-HSA-71240 | Tryptophan catabolism | 3.530743e-01 | 0.452 |
| R-HSA-8982491 | Glycogen metabolism | 3.530743e-01 | 0.452 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.530743e-01 | 0.452 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 3.554330e-01 | 0.449 |
| R-HSA-73886 | Chromosome Maintenance | 3.554330e-01 | 0.449 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.590502e-01 | 0.445 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.590502e-01 | 0.445 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.590502e-01 | 0.445 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 3.590502e-01 | 0.445 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.620816e-01 | 0.441 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.649712e-01 | 0.438 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.649712e-01 | 0.438 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 3.649712e-01 | 0.438 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 3.649712e-01 | 0.438 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.649712e-01 | 0.438 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 3.649712e-01 | 0.438 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 3.649712e-01 | 0.438 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.649712e-01 | 0.438 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.649712e-01 | 0.438 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.653965e-01 | 0.437 |
| R-HSA-194138 | Signaling by VEGF | 3.720067e-01 | 0.429 |
| R-HSA-68882 | Mitotic Anaphase | 3.732713e-01 | 0.428 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.757747e-01 | 0.425 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.766509e-01 | 0.424 |
| R-HSA-8854214 | TBC/RABGAPs | 3.766509e-01 | 0.424 |
| R-HSA-69481 | G2/M Checkpoints | 3.785895e-01 | 0.422 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 3.793566e-01 | 0.421 |
| R-HSA-69236 | G1 Phase | 3.824104e-01 | 0.417 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.824104e-01 | 0.417 |
| R-HSA-9907900 | Proteasome assembly | 3.824104e-01 | 0.417 |
| R-HSA-190828 | Gap junction trafficking | 3.824104e-01 | 0.417 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.824104e-01 | 0.417 |
| R-HSA-156581 | Methylation | 3.824104e-01 | 0.417 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 3.881171e-01 | 0.411 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.881171e-01 | 0.411 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.881171e-01 | 0.411 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 3.881171e-01 | 0.411 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.881171e-01 | 0.411 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.881171e-01 | 0.411 |
| R-HSA-9824272 | Somitogenesis | 3.881171e-01 | 0.411 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.937714e-01 | 0.405 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 3.937714e-01 | 0.405 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 3.937714e-01 | 0.405 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 3.937714e-01 | 0.405 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 3.937714e-01 | 0.405 |
| R-HSA-6802949 | Signaling by RAS mutants | 3.937714e-01 | 0.405 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 3.937714e-01 | 0.405 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 3.937714e-01 | 0.405 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 3.981627e-01 | 0.400 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 3.981627e-01 | 0.400 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.982089e-01 | 0.400 |
| R-HSA-392499 | Metabolism of proteins | 3.984099e-01 | 0.400 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 3.993738e-01 | 0.399 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 3.993738e-01 | 0.399 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.993738e-01 | 0.399 |
| R-HSA-437239 | Recycling pathway of L1 | 3.993738e-01 | 0.399 |
| R-HSA-162906 | HIV Infection | 4.006894e-01 | 0.397 |
| R-HSA-5620924 | Intraflagellar transport | 4.049247e-01 | 0.393 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.049247e-01 | 0.393 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 4.056419e-01 | 0.392 |
| R-HSA-1474244 | Extracellular matrix organization | 4.087005e-01 | 0.389 |
| R-HSA-157858 | Gap junction trafficking and regulation | 4.104247e-01 | 0.387 |
| R-HSA-9766229 | Degradation of CDH1 | 4.104247e-01 | 0.387 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.104247e-01 | 0.387 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.104247e-01 | 0.387 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 4.158743e-01 | 0.381 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.212737e-01 | 0.375 |
| R-HSA-6807070 | PTEN Regulation | 4.238105e-01 | 0.373 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.238105e-01 | 0.373 |
| R-HSA-199991 | Membrane Trafficking | 4.248494e-01 | 0.372 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.266236e-01 | 0.370 |
| R-HSA-68949 | Orc1 removal from chromatin | 4.266236e-01 | 0.370 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 4.266236e-01 | 0.370 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.301357e-01 | 0.366 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.319244e-01 | 0.365 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.319244e-01 | 0.365 |
| R-HSA-72649 | Translation initiation complex formation | 4.371765e-01 | 0.359 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.371765e-01 | 0.359 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.423803e-01 | 0.354 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.423803e-01 | 0.354 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.475364e-01 | 0.349 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.475364e-01 | 0.349 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.475364e-01 | 0.349 |
| R-HSA-5578775 | Ion homeostasis | 4.475364e-01 | 0.349 |
| R-HSA-5621480 | Dectin-2 family | 4.526451e-01 | 0.344 |
| R-HSA-9764561 | Regulation of CDH1 Function | 4.526451e-01 | 0.344 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 4.526451e-01 | 0.344 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.550641e-01 | 0.342 |
| R-HSA-69242 | S Phase | 4.550641e-01 | 0.342 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.577069e-01 | 0.339 |
| R-HSA-421270 | Cell-cell junction organization | 4.592230e-01 | 0.338 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 4.627221e-01 | 0.335 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.627221e-01 | 0.335 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.672948e-01 | 0.330 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 4.672948e-01 | 0.330 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.676913e-01 | 0.330 |
| R-HSA-983189 | Kinesins | 4.676913e-01 | 0.330 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.676913e-01 | 0.330 |
| R-HSA-351202 | Metabolism of polyamines | 4.676913e-01 | 0.330 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 4.676913e-01 | 0.330 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.676913e-01 | 0.330 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.676913e-01 | 0.330 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.676913e-01 | 0.330 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.676913e-01 | 0.330 |
| R-HSA-109582 | Hemostasis | 4.695026e-01 | 0.328 |
| R-HSA-69306 | DNA Replication | 4.703272e-01 | 0.328 |
| R-HSA-445717 | Aquaporin-mediated transport | 4.726149e-01 | 0.325 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 4.726149e-01 | 0.325 |
| R-HSA-450294 | MAP kinase activation | 4.726149e-01 | 0.325 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.726149e-01 | 0.325 |
| R-HSA-1442490 | Collagen degradation | 4.726149e-01 | 0.325 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.742063e-01 | 0.324 |
| R-HSA-69620 | Cell Cycle Checkpoints | 4.758568e-01 | 0.323 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 4.763614e-01 | 0.322 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 4.774932e-01 | 0.321 |
| R-HSA-1268020 | Mitochondrial protein import | 4.774932e-01 | 0.321 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.774932e-01 | 0.321 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.774932e-01 | 0.321 |
| R-HSA-186797 | Signaling by PDGF | 4.774932e-01 | 0.321 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 4.823267e-01 | 0.317 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 4.823267e-01 | 0.317 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.823267e-01 | 0.317 |
| R-HSA-162587 | HIV Life Cycle | 4.823542e-01 | 0.317 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.853348e-01 | 0.314 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.871158e-01 | 0.312 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.875953e-01 | 0.312 |
| R-HSA-877300 | Interferon gamma signaling | 4.883049e-01 | 0.311 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.912644e-01 | 0.309 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 4.918608e-01 | 0.308 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.918608e-01 | 0.308 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 4.965623e-01 | 0.304 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 4.965623e-01 | 0.304 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.992077e-01 | 0.302 |
| R-HSA-5693606 | DNA Double Strand Break Response | 5.012205e-01 | 0.300 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.012205e-01 | 0.300 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.027700e-01 | 0.299 |
| R-HSA-913709 | O-linked glycosylation of mucins | 5.058359e-01 | 0.296 |
| R-HSA-448424 | Interleukin-17 signaling | 5.149399e-01 | 0.288 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.149399e-01 | 0.288 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 5.149399e-01 | 0.288 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.149399e-01 | 0.288 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 5.194292e-01 | 0.284 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.194292e-01 | 0.284 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.194292e-01 | 0.284 |
| R-HSA-8978934 | Metabolism of cofactors | 5.194292e-01 | 0.284 |
| R-HSA-168256 | Immune System | 5.202087e-01 | 0.284 |
| R-HSA-446728 | Cell junction organization | 5.220310e-01 | 0.282 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.238773e-01 | 0.281 |
| R-HSA-74259 | Purine catabolism | 5.238773e-01 | 0.281 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.282844e-01 | 0.277 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.282844e-01 | 0.277 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.282844e-01 | 0.277 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.287482e-01 | 0.277 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.315539e-01 | 0.274 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.315539e-01 | 0.274 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.315539e-01 | 0.274 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.326510e-01 | 0.274 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.326510e-01 | 0.274 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.326510e-01 | 0.274 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.343483e-01 | 0.272 |
| R-HSA-380287 | Centrosome maturation | 5.369775e-01 | 0.270 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.369775e-01 | 0.270 |
| R-HSA-5689603 | UCH proteinases | 5.412642e-01 | 0.267 |
| R-HSA-168255 | Influenza Infection | 5.481500e-01 | 0.261 |
| R-HSA-5619084 | ABC transporter disorders | 5.497196e-01 | 0.260 |
| R-HSA-4086400 | PCP/CE pathway | 5.497196e-01 | 0.260 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 5.497196e-01 | 0.260 |
| R-HSA-2559583 | Cellular Senescence | 5.508760e-01 | 0.259 |
| R-HSA-6806834 | Signaling by MET | 5.580203e-01 | 0.253 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.580203e-01 | 0.253 |
| R-HSA-1266738 | Developmental Biology | 5.582464e-01 | 0.253 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.589854e-01 | 0.253 |
| R-HSA-1483257 | Phospholipid metabolism | 5.595063e-01 | 0.252 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.621134e-01 | 0.250 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.661689e-01 | 0.247 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.701871e-01 | 0.244 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.741683e-01 | 0.241 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 5.741683e-01 | 0.241 |
| R-HSA-983712 | Ion channel transport | 5.748922e-01 | 0.240 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.781128e-01 | 0.238 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.801017e-01 | 0.236 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.820211e-01 | 0.235 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.820211e-01 | 0.235 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.858934e-01 | 0.232 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.858934e-01 | 0.232 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.897301e-01 | 0.229 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 5.929216e-01 | 0.227 |
| R-HSA-156902 | Peptide chain elongation | 5.935315e-01 | 0.227 |
| R-HSA-9645723 | Diseases of programmed cell death | 5.935315e-01 | 0.227 |
| R-HSA-597592 | Post-translational protein modification | 5.974326e-01 | 0.224 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.010296e-01 | 0.221 |
| R-HSA-73884 | Base Excision Repair | 6.010296e-01 | 0.221 |
| R-HSA-212436 | Generic Transcription Pathway | 6.011700e-01 | 0.221 |
| R-HSA-389948 | Co-inhibition by PD-1 | 6.029677e-01 | 0.220 |
| R-HSA-1500931 | Cell-Cell communication | 6.033030e-01 | 0.219 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.047269e-01 | 0.218 |
| R-HSA-428157 | Sphingolipid metabolism | 6.054500e-01 | 0.218 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.083902e-01 | 0.216 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.113168e-01 | 0.214 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 6.120198e-01 | 0.213 |
| R-HSA-72172 | mRNA Splicing | 6.152628e-01 | 0.211 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 6.156160e-01 | 0.211 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.227094e-01 | 0.206 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.262071e-01 | 0.203 |
| R-HSA-162582 | Signal Transduction | 6.325962e-01 | 0.199 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.343299e-01 | 0.198 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.365083e-01 | 0.196 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.365083e-01 | 0.196 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.365083e-01 | 0.196 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.365083e-01 | 0.196 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.432186e-01 | 0.192 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.465274e-01 | 0.189 |
| R-HSA-418990 | Adherens junctions interactions | 6.481439e-01 | 0.188 |
| R-HSA-6798695 | Neutrophil degranulation | 6.482425e-01 | 0.188 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.498058e-01 | 0.187 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 6.498058e-01 | 0.187 |
| R-HSA-192823 | Viral mRNA Translation | 6.530540e-01 | 0.185 |
| R-HSA-8951664 | Neddylation | 6.548957e-01 | 0.184 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 6.562722e-01 | 0.183 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.562722e-01 | 0.183 |
| R-HSA-111885 | Opioid Signalling | 6.562722e-01 | 0.183 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.562722e-01 | 0.183 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 6.688513e-01 | 0.175 |
| R-HSA-211000 | Gene Silencing by RNA | 6.688513e-01 | 0.175 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.719240e-01 | 0.173 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.719240e-01 | 0.173 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.719240e-01 | 0.173 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.749683e-01 | 0.171 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.749683e-01 | 0.171 |
| R-HSA-73894 | DNA Repair | 6.854474e-01 | 0.164 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.868676e-01 | 0.163 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.868676e-01 | 0.163 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 6.897742e-01 | 0.161 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.926540e-01 | 0.159 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 6.955072e-01 | 0.158 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.019006e-01 | 0.154 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.039100e-01 | 0.152 |
| R-HSA-5693538 | Homology Directed Repair | 7.066594e-01 | 0.151 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.093834e-01 | 0.149 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.093834e-01 | 0.149 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.093834e-01 | 0.149 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 7.147564e-01 | 0.146 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.174057e-01 | 0.144 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.174057e-01 | 0.144 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.200307e-01 | 0.143 |
| R-HSA-5663205 | Infectious disease | 7.258236e-01 | 0.139 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.262322e-01 | 0.139 |
| R-HSA-69206 | G1/S Transition | 7.277610e-01 | 0.138 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.282300e-01 | 0.138 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 7.339799e-01 | 0.134 |
| R-HSA-8956319 | Nucleotide catabolism | 7.377392e-01 | 0.132 |
| R-HSA-416476 | G alpha (q) signalling events | 7.406887e-01 | 0.130 |
| R-HSA-5576891 | Cardiac conduction | 7.449837e-01 | 0.128 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.588816e-01 | 0.120 |
| R-HSA-5173105 | O-linked glycosylation | 7.611237e-01 | 0.119 |
| R-HSA-74160 | Gene expression (Transcription) | 7.612082e-01 | 0.118 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.660515e-01 | 0.116 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.692667e-01 | 0.114 |
| R-HSA-9658195 | Leishmania infection | 7.692667e-01 | 0.114 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.762486e-01 | 0.110 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 7.801222e-01 | 0.108 |
| R-HSA-5668914 | Diseases of metabolism | 7.865309e-01 | 0.104 |
| R-HSA-9758941 | Gastrulation | 7.884531e-01 | 0.103 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.904219e-01 | 0.102 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 7.907198e-01 | 0.102 |
| R-HSA-195721 | Signaling by WNT | 7.950835e-01 | 0.100 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 7.962197e-01 | 0.099 |
| R-HSA-9609507 | Protein localization | 7.962197e-01 | 0.099 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 7.981167e-01 | 0.098 |
| R-HSA-9711097 | Cellular response to starvation | 8.055308e-01 | 0.094 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.091358e-01 | 0.092 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.161478e-01 | 0.088 |
| R-HSA-382551 | Transport of small molecules | 8.255006e-01 | 0.083 |
| R-HSA-72306 | tRNA processing | 8.278086e-01 | 0.082 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.284387e-01 | 0.082 |
| R-HSA-418555 | G alpha (s) signalling events | 8.294133e-01 | 0.081 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.325783e-01 | 0.080 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.325783e-01 | 0.080 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.356850e-01 | 0.078 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 8.356850e-01 | 0.078 |
| R-HSA-3781865 | Diseases of glycosylation | 8.489713e-01 | 0.071 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.504546e-01 | 0.070 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.517758e-01 | 0.070 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.624855e-01 | 0.064 |
| R-HSA-9609690 | HCMV Early Events | 8.650406e-01 | 0.063 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.727344e-01 | 0.059 |
| R-HSA-397014 | Muscle contraction | 8.849392e-01 | 0.053 |
| R-HSA-168249 | Innate Immune System | 8.852755e-01 | 0.053 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.959175e-01 | 0.048 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.012566e-01 | 0.045 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.028382e-01 | 0.044 |
| R-HSA-15869 | Metabolism of nucleotides | 9.081668e-01 | 0.042 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.107213e-01 | 0.041 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.171931e-01 | 0.038 |
| R-HSA-9609646 | HCMV Infection | 9.194980e-01 | 0.036 |
| R-HSA-1643685 | Disease | 9.350886e-01 | 0.029 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.357840e-01 | 0.029 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.381602e-01 | 0.028 |
| R-HSA-388396 | GPCR downstream signalling | 9.395740e-01 | 0.027 |
| R-HSA-112316 | Neuronal System | 9.427459e-01 | 0.026 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 9.595644e-01 | 0.018 |
| R-HSA-211859 | Biological oxidations | 9.629130e-01 | 0.016 |
| R-HSA-372790 | Signaling by GPCR | 9.647093e-01 | 0.016 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.795611e-01 | 0.009 |
| R-HSA-418594 | G alpha (i) signalling events | 9.819360e-01 | 0.008 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.885619e-01 | 0.005 |
| R-HSA-500792 | GPCR ligand binding | 9.968298e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.987180e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.996206e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.836 | 0.369 | 2 | 0.774 |
CK2A2 |
0.830 | 0.558 | 1 | 0.797 |
COT |
0.826 | 0.218 | 2 | 0.828 |
BMPR1B |
0.820 | 0.361 | 1 | 0.782 |
CK2A1 |
0.817 | 0.496 | 1 | 0.773 |
MOS |
0.817 | 0.260 | 1 | 0.890 |
GRK1 |
0.816 | 0.242 | -2 | 0.757 |
CDC7 |
0.816 | 0.154 | 1 | 0.868 |
BMPR1A |
0.813 | 0.377 | 1 | 0.773 |
TGFBR1 |
0.813 | 0.355 | -2 | 0.889 |
GRK6 |
0.812 | 0.318 | 1 | 0.765 |
ALK2 |
0.812 | 0.411 | -2 | 0.893 |
DSTYK |
0.810 | 0.148 | 2 | 0.852 |
GRK7 |
0.809 | 0.328 | 1 | 0.702 |
IKKA |
0.808 | 0.182 | -2 | 0.703 |
CLK3 |
0.808 | 0.119 | 1 | 0.771 |
CAMK2G |
0.808 | 0.156 | 2 | 0.802 |
IKKB |
0.806 | 0.064 | -2 | 0.701 |
ACVR2B |
0.805 | 0.311 | -2 | 0.889 |
PLK3 |
0.803 | 0.271 | 2 | 0.758 |
ATM |
0.803 | 0.113 | 1 | 0.682 |
ACVR2A |
0.803 | 0.295 | -2 | 0.888 |
PRPK |
0.802 | -0.004 | -1 | 0.838 |
PIM3 |
0.801 | 0.036 | -3 | 0.739 |
GCN2 |
0.800 | -0.055 | 2 | 0.752 |
GRK4 |
0.800 | 0.133 | -2 | 0.814 |
BMPR2 |
0.799 | 0.101 | -2 | 0.869 |
ALK4 |
0.799 | 0.264 | -2 | 0.898 |
GRK5 |
0.798 | 0.090 | -3 | 0.832 |
KIS |
0.797 | 0.052 | 1 | 0.629 |
PLK1 |
0.796 | 0.197 | -2 | 0.862 |
CAMK2B |
0.796 | 0.173 | 2 | 0.797 |
PDHK4 |
0.794 | -0.148 | 1 | 0.771 |
PLK2 |
0.792 | 0.274 | -3 | 0.890 |
TGFBR2 |
0.792 | 0.057 | -2 | 0.898 |
RAF1 |
0.792 | -0.107 | 1 | 0.749 |
NDR2 |
0.792 | -0.026 | -3 | 0.731 |
NEK6 |
0.791 | -0.025 | -2 | 0.868 |
TBK1 |
0.791 | -0.084 | 1 | 0.625 |
MTOR |
0.791 | -0.133 | 1 | 0.703 |
IKKE |
0.791 | -0.073 | 1 | 0.613 |
ATR |
0.790 | -0.037 | 1 | 0.739 |
CAMK1B |
0.789 | -0.058 | -3 | 0.779 |
LATS1 |
0.789 | 0.139 | -3 | 0.752 |
PIM1 |
0.787 | 0.028 | -3 | 0.681 |
ERK5 |
0.787 | -0.021 | 1 | 0.759 |
NEK7 |
0.787 | -0.094 | -3 | 0.775 |
ULK2 |
0.786 | -0.165 | 2 | 0.746 |
HUNK |
0.785 | -0.085 | 2 | 0.744 |
MLK1 |
0.785 | -0.093 | 2 | 0.759 |
PDHK1 |
0.785 | -0.185 | 1 | 0.742 |
SKMLCK |
0.784 | -0.024 | -2 | 0.775 |
PKN3 |
0.784 | -0.059 | -3 | 0.745 |
RSK2 |
0.783 | -0.001 | -3 | 0.666 |
BCKDK |
0.782 | -0.108 | -1 | 0.807 |
CDKL1 |
0.781 | -0.074 | -3 | 0.716 |
CAMK2A |
0.781 | 0.072 | 2 | 0.791 |
LATS2 |
0.781 | -0.010 | -5 | 0.708 |
GRK2 |
0.780 | 0.051 | -2 | 0.707 |
CAMLCK |
0.780 | -0.072 | -2 | 0.780 |
MARK4 |
0.780 | -0.089 | 4 | 0.703 |
MAPKAPK2 |
0.779 | 0.046 | -3 | 0.598 |
NLK |
0.779 | -0.140 | 1 | 0.741 |
ULK1 |
0.779 | -0.132 | -3 | 0.785 |
TTBK2 |
0.778 | -0.078 | 2 | 0.664 |
SRPK1 |
0.778 | -0.033 | -3 | 0.656 |
NIK |
0.777 | -0.194 | -3 | 0.800 |
GRK3 |
0.777 | 0.086 | -2 | 0.679 |
CLK2 |
0.776 | 0.065 | -3 | 0.662 |
DAPK2 |
0.776 | -0.103 | -3 | 0.778 |
TLK2 |
0.776 | 0.058 | 1 | 0.677 |
CAMK2D |
0.776 | -0.048 | -3 | 0.724 |
PRKD1 |
0.776 | -0.080 | -3 | 0.685 |
RIPK3 |
0.775 | -0.214 | 3 | 0.543 |
DLK |
0.774 | -0.136 | 1 | 0.731 |
JNK3 |
0.774 | 0.043 | 1 | 0.587 |
CHAK2 |
0.774 | -0.143 | -1 | 0.773 |
NDR1 |
0.774 | -0.127 | -3 | 0.725 |
P90RSK |
0.773 | -0.057 | -3 | 0.676 |
NUAK2 |
0.773 | -0.125 | -3 | 0.745 |
MASTL |
0.773 | -0.254 | -2 | 0.749 |
ANKRD3 |
0.772 | -0.171 | 1 | 0.752 |
CDK8 |
0.772 | -0.039 | 1 | 0.584 |
RSK4 |
0.771 | 0.012 | -3 | 0.639 |
NEK9 |
0.771 | -0.206 | 2 | 0.772 |
MLK3 |
0.771 | -0.086 | 2 | 0.703 |
MLK4 |
0.771 | -0.040 | 2 | 0.683 |
P70S6KB |
0.771 | -0.074 | -3 | 0.698 |
CDKL5 |
0.771 | -0.085 | -3 | 0.693 |
TSSK2 |
0.771 | -0.090 | -5 | 0.720 |
DNAPK |
0.770 | 0.015 | 1 | 0.580 |
SRPK2 |
0.770 | -0.032 | -3 | 0.588 |
AMPKA1 |
0.770 | -0.129 | -3 | 0.742 |
MSK2 |
0.770 | -0.046 | -3 | 0.635 |
SRPK3 |
0.770 | -0.041 | -3 | 0.654 |
MEK1 |
0.770 | -0.098 | 2 | 0.791 |
GSK3A |
0.770 | 0.057 | 4 | 0.475 |
PKR |
0.769 | -0.091 | 1 | 0.767 |
RSK3 |
0.769 | -0.083 | -3 | 0.675 |
HIPK4 |
0.768 | -0.105 | 1 | 0.717 |
TLK1 |
0.767 | 0.028 | -2 | 0.875 |
JNK2 |
0.767 | 0.027 | 1 | 0.544 |
MST4 |
0.767 | -0.162 | 2 | 0.770 |
ICK |
0.767 | -0.106 | -3 | 0.736 |
PKCD |
0.767 | -0.116 | 2 | 0.747 |
PRKX |
0.767 | 0.028 | -3 | 0.565 |
PAK1 |
0.767 | -0.061 | -2 | 0.692 |
AURA |
0.767 | 0.004 | -2 | 0.589 |
YSK4 |
0.766 | -0.118 | 1 | 0.674 |
CDK1 |
0.766 | -0.014 | 1 | 0.559 |
MSK1 |
0.766 | -0.013 | -3 | 0.637 |
BRAF |
0.766 | -0.004 | -4 | 0.799 |
MAPKAPK3 |
0.766 | -0.094 | -3 | 0.639 |
PERK |
0.765 | -0.054 | -2 | 0.870 |
PRKD2 |
0.765 | -0.095 | -3 | 0.637 |
CK1E |
0.765 | -0.004 | -3 | 0.587 |
NIM1 |
0.765 | -0.174 | 3 | 0.601 |
DYRK2 |
0.765 | -0.042 | 1 | 0.635 |
PKACG |
0.764 | -0.094 | -2 | 0.662 |
IRE2 |
0.764 | -0.144 | 2 | 0.718 |
WNK3 |
0.764 | -0.325 | 1 | 0.721 |
MEKK3 |
0.764 | -0.089 | 1 | 0.703 |
MLK2 |
0.764 | -0.252 | 2 | 0.772 |
CDK19 |
0.763 | -0.050 | 1 | 0.548 |
SMG1 |
0.763 | -0.090 | 1 | 0.691 |
AMPKA2 |
0.763 | -0.131 | -3 | 0.702 |
CLK4 |
0.763 | -0.032 | -3 | 0.679 |
WNK1 |
0.763 | -0.240 | -2 | 0.763 |
TSSK1 |
0.763 | -0.127 | -3 | 0.761 |
MARK2 |
0.762 | -0.079 | 4 | 0.618 |
BRSK1 |
0.762 | -0.092 | -3 | 0.686 |
PKN2 |
0.762 | -0.185 | -3 | 0.735 |
AURC |
0.761 | -0.057 | -2 | 0.600 |
PKACB |
0.761 | -0.015 | -2 | 0.613 |
VRK2 |
0.761 | -0.334 | 1 | 0.793 |
CAMK4 |
0.760 | -0.162 | -3 | 0.719 |
RIPK1 |
0.760 | -0.307 | 1 | 0.730 |
HRI |
0.760 | -0.133 | -2 | 0.867 |
PASK |
0.760 | 0.002 | -3 | 0.757 |
CHK1 |
0.760 | -0.066 | -3 | 0.714 |
QSK |
0.760 | -0.115 | 4 | 0.674 |
CK1D |
0.759 | 0.009 | -3 | 0.533 |
GSK3B |
0.759 | -0.013 | 4 | 0.459 |
MYLK4 |
0.757 | -0.085 | -2 | 0.697 |
MEKK2 |
0.757 | -0.120 | 2 | 0.762 |
DRAK1 |
0.757 | -0.099 | 1 | 0.679 |
PAK3 |
0.757 | -0.148 | -2 | 0.691 |
P38G |
0.757 | -0.006 | 1 | 0.479 |
IRE1 |
0.757 | -0.247 | 1 | 0.728 |
PAK2 |
0.756 | -0.112 | -2 | 0.682 |
MARK3 |
0.756 | -0.098 | 4 | 0.633 |
PINK1 |
0.756 | -0.158 | 1 | 0.748 |
P38B |
0.756 | -0.019 | 1 | 0.574 |
P38D |
0.756 | 0.015 | 1 | 0.513 |
MEKK1 |
0.756 | -0.176 | 1 | 0.704 |
CDK13 |
0.755 | -0.073 | 1 | 0.583 |
CDK5 |
0.755 | -0.063 | 1 | 0.623 |
NUAK1 |
0.755 | -0.152 | -3 | 0.690 |
SIK |
0.755 | -0.129 | -3 | 0.661 |
PRP4 |
0.755 | -0.027 | -3 | 0.725 |
GAK |
0.755 | 0.012 | 1 | 0.787 |
AURB |
0.754 | -0.071 | -2 | 0.598 |
PIM2 |
0.753 | -0.061 | -3 | 0.642 |
CLK1 |
0.753 | -0.059 | -3 | 0.645 |
JNK1 |
0.753 | 0.020 | 1 | 0.538 |
DYRK4 |
0.753 | -0.012 | 1 | 0.566 |
ERK1 |
0.753 | -0.045 | 1 | 0.563 |
P38A |
0.752 | -0.060 | 1 | 0.640 |
MARK1 |
0.752 | -0.117 | 4 | 0.654 |
ERK2 |
0.752 | -0.066 | 1 | 0.607 |
PLK4 |
0.752 | -0.132 | 2 | 0.587 |
CK1G1 |
0.752 | -0.056 | -3 | 0.603 |
CDK3 |
0.751 | -0.020 | 1 | 0.508 |
CDK2 |
0.751 | -0.088 | 1 | 0.625 |
PKCB |
0.751 | -0.146 | 2 | 0.695 |
NEK2 |
0.751 | -0.223 | 2 | 0.752 |
CDK7 |
0.750 | -0.108 | 1 | 0.608 |
QIK |
0.750 | -0.247 | -3 | 0.730 |
CK1A2 |
0.750 | -0.022 | -3 | 0.534 |
NEK5 |
0.750 | -0.200 | 1 | 0.741 |
PKCG |
0.749 | -0.169 | 2 | 0.695 |
MEK5 |
0.749 | -0.322 | 2 | 0.776 |
MELK |
0.749 | -0.205 | -3 | 0.681 |
CAMKK1 |
0.749 | -0.119 | -2 | 0.719 |
PRKD3 |
0.749 | -0.142 | -3 | 0.634 |
CHAK1 |
0.749 | -0.274 | 2 | 0.721 |
PKCA |
0.749 | -0.159 | 2 | 0.687 |
CAMK1G |
0.749 | -0.128 | -3 | 0.672 |
ZAK |
0.748 | -0.201 | 1 | 0.665 |
DCAMKL1 |
0.748 | -0.110 | -3 | 0.673 |
PAK6 |
0.748 | -0.082 | -2 | 0.629 |
PKCH |
0.747 | -0.176 | 2 | 0.684 |
TAO3 |
0.747 | -0.130 | 1 | 0.699 |
MAPKAPK5 |
0.747 | -0.166 | -3 | 0.616 |
MST2 |
0.747 | -0.063 | 1 | 0.698 |
BRSK2 |
0.746 | -0.196 | -3 | 0.698 |
HIPK2 |
0.746 | -0.048 | 1 | 0.558 |
ALPHAK3 |
0.746 | 0.137 | -1 | 0.784 |
DYRK1A |
0.746 | -0.077 | 1 | 0.669 |
CDK18 |
0.746 | -0.074 | 1 | 0.543 |
AKT2 |
0.746 | -0.084 | -3 | 0.592 |
DYRK1B |
0.745 | -0.045 | 1 | 0.592 |
NEK8 |
0.745 | -0.186 | 2 | 0.764 |
PKACA |
0.745 | -0.033 | -2 | 0.566 |
TTBK1 |
0.745 | -0.143 | 2 | 0.593 |
PKCZ |
0.745 | -0.207 | 2 | 0.730 |
CDK12 |
0.745 | -0.080 | 1 | 0.553 |
SGK3 |
0.745 | -0.098 | -3 | 0.641 |
HIPK1 |
0.744 | -0.075 | 1 | 0.651 |
EEF2K |
0.744 | -0.072 | 3 | 0.616 |
SMMLCK |
0.744 | -0.124 | -3 | 0.723 |
CDK17 |
0.744 | -0.068 | 1 | 0.485 |
SNRK |
0.743 | -0.280 | 2 | 0.650 |
DAPK3 |
0.743 | -0.042 | -3 | 0.700 |
MNK2 |
0.743 | -0.175 | -2 | 0.710 |
CAMK1D |
0.743 | -0.061 | -3 | 0.569 |
MNK1 |
0.743 | -0.157 | -2 | 0.724 |
PKG2 |
0.743 | -0.110 | -2 | 0.602 |
PHKG1 |
0.743 | -0.230 | -3 | 0.712 |
TTK |
0.740 | 0.060 | -2 | 0.881 |
DYRK3 |
0.740 | -0.064 | 1 | 0.655 |
DAPK1 |
0.740 | -0.039 | -3 | 0.689 |
CDK9 |
0.740 | -0.115 | 1 | 0.590 |
CAMKK2 |
0.740 | -0.168 | -2 | 0.704 |
SSTK |
0.739 | -0.146 | 4 | 0.647 |
PDHK3_TYR |
0.739 | 0.273 | 4 | 0.807 |
DCAMKL2 |
0.739 | -0.131 | -3 | 0.700 |
ERK7 |
0.738 | -0.049 | 2 | 0.500 |
TAK1 |
0.738 | -0.123 | 1 | 0.704 |
WNK4 |
0.738 | -0.279 | -2 | 0.755 |
P70S6K |
0.736 | -0.121 | -3 | 0.605 |
TAO2 |
0.736 | -0.215 | 2 | 0.796 |
LKB1 |
0.736 | -0.198 | -3 | 0.753 |
MST3 |
0.736 | -0.224 | 2 | 0.763 |
MPSK1 |
0.735 | -0.157 | 1 | 0.729 |
MAP2K6_TYR |
0.735 | 0.216 | -1 | 0.872 |
IRAK4 |
0.735 | -0.301 | 1 | 0.731 |
GCK |
0.733 | -0.175 | 1 | 0.674 |
HIPK3 |
0.733 | -0.131 | 1 | 0.651 |
PDK1 |
0.733 | -0.197 | 1 | 0.711 |
TNIK |
0.733 | -0.159 | 3 | 0.617 |
PDHK4_TYR |
0.732 | 0.179 | 2 | 0.842 |
IRAK1 |
0.732 | -0.315 | -1 | 0.717 |
CDK16 |
0.732 | -0.067 | 1 | 0.508 |
NEK11 |
0.732 | -0.316 | 1 | 0.671 |
AKT1 |
0.732 | -0.096 | -3 | 0.593 |
PDHK1_TYR |
0.731 | 0.181 | -1 | 0.890 |
MAP2K4_TYR |
0.731 | 0.122 | -1 | 0.871 |
PKCT |
0.731 | -0.197 | 2 | 0.691 |
SGK1 |
0.730 | -0.043 | -3 | 0.504 |
MST1 |
0.730 | -0.158 | 1 | 0.677 |
CDK14 |
0.729 | -0.110 | 1 | 0.573 |
TXK |
0.729 | 0.173 | 1 | 0.817 |
VRK1 |
0.729 | -0.252 | 2 | 0.773 |
MINK |
0.728 | -0.217 | 1 | 0.673 |
BMPR2_TYR |
0.728 | 0.098 | -1 | 0.877 |
PAK5 |
0.728 | -0.115 | -2 | 0.578 |
OSR1 |
0.728 | -0.072 | 2 | 0.740 |
SBK |
0.727 | -0.036 | -3 | 0.466 |
PAK4 |
0.727 | -0.100 | -2 | 0.588 |
HGK |
0.726 | -0.234 | 3 | 0.604 |
PHKG2 |
0.726 | -0.232 | -3 | 0.700 |
NEK4 |
0.726 | -0.313 | 1 | 0.690 |
LRRK2 |
0.725 | -0.297 | 2 | 0.789 |
MEK2 |
0.725 | -0.244 | 2 | 0.753 |
EPHA6 |
0.725 | 0.076 | -1 | 0.901 |
BLK |
0.724 | 0.132 | -1 | 0.858 |
NEK1 |
0.724 | -0.282 | 1 | 0.717 |
EPHB4 |
0.723 | 0.059 | -1 | 0.888 |
FER |
0.722 | 0.103 | 1 | 0.824 |
EPHA4 |
0.722 | 0.118 | 2 | 0.757 |
CK1A |
0.722 | -0.022 | -3 | 0.462 |
MAP2K7_TYR |
0.721 | -0.096 | 2 | 0.818 |
YES1 |
0.721 | 0.063 | -1 | 0.845 |
TESK1_TYR |
0.721 | -0.129 | 3 | 0.665 |
INSRR |
0.720 | 0.067 | 3 | 0.527 |
SRMS |
0.720 | 0.110 | 1 | 0.801 |
CDK10 |
0.720 | -0.110 | 1 | 0.563 |
FYN |
0.720 | 0.143 | -1 | 0.830 |
CAMK1A |
0.720 | -0.110 | -3 | 0.544 |
PKCI |
0.720 | -0.221 | 2 | 0.693 |
RIPK2 |
0.720 | -0.304 | 1 | 0.639 |
EPHB2 |
0.720 | 0.112 | -1 | 0.878 |
PKCE |
0.719 | -0.164 | 2 | 0.679 |
PINK1_TYR |
0.719 | -0.115 | 1 | 0.779 |
PBK |
0.719 | -0.113 | 1 | 0.733 |
AKT3 |
0.719 | -0.086 | -3 | 0.513 |
YANK3 |
0.719 | -0.061 | 2 | 0.400 |
CDK6 |
0.719 | -0.104 | 1 | 0.561 |
HPK1 |
0.719 | -0.240 | 1 | 0.657 |
SLK |
0.718 | -0.189 | -2 | 0.656 |
CDK4 |
0.718 | -0.097 | 1 | 0.541 |
ROCK2 |
0.718 | -0.109 | -3 | 0.668 |
MAP3K15 |
0.718 | -0.320 | 1 | 0.658 |
MRCKA |
0.718 | -0.114 | -3 | 0.645 |
MAK |
0.717 | -0.063 | -2 | 0.622 |
ABL2 |
0.717 | 0.003 | -1 | 0.824 |
KHS1 |
0.717 | -0.208 | 1 | 0.659 |
LCK |
0.717 | 0.057 | -1 | 0.851 |
LOK |
0.716 | -0.256 | -2 | 0.696 |
EPHB3 |
0.716 | 0.055 | -1 | 0.882 |
MEKK6 |
0.716 | -0.366 | 1 | 0.696 |
FGR |
0.716 | -0.009 | 1 | 0.787 |
STK33 |
0.716 | -0.227 | 2 | 0.591 |
MRCKB |
0.716 | -0.115 | -3 | 0.631 |
BIKE |
0.715 | -0.032 | 1 | 0.684 |
CHK2 |
0.715 | -0.136 | -3 | 0.530 |
PKMYT1_TYR |
0.715 | -0.204 | 3 | 0.623 |
KHS2 |
0.714 | -0.181 | 1 | 0.660 |
MOK |
0.714 | -0.093 | 1 | 0.688 |
EPHB1 |
0.714 | 0.028 | 1 | 0.783 |
YSK1 |
0.714 | -0.257 | 2 | 0.743 |
HCK |
0.714 | 0.005 | -1 | 0.849 |
PKN1 |
0.713 | -0.175 | -3 | 0.613 |
RET |
0.712 | -0.133 | 1 | 0.711 |
DMPK1 |
0.711 | -0.084 | -3 | 0.656 |
EPHA5 |
0.711 | 0.109 | 2 | 0.754 |
SYK |
0.710 | 0.154 | -1 | 0.843 |
CK1G3 |
0.710 | -0.014 | -3 | 0.422 |
TYK2 |
0.710 | -0.194 | 1 | 0.707 |
ABL1 |
0.709 | -0.050 | -1 | 0.813 |
PTK2 |
0.709 | 0.119 | -1 | 0.845 |
JAK3 |
0.709 | -0.079 | 1 | 0.705 |
CSF1R |
0.708 | -0.106 | 3 | 0.553 |
FGFR2 |
0.707 | -0.041 | 3 | 0.565 |
ITK |
0.707 | -0.033 | -1 | 0.817 |
EGFR |
0.707 | 0.073 | 1 | 0.582 |
TYRO3 |
0.706 | -0.179 | 3 | 0.557 |
EPHA7 |
0.706 | 0.018 | 2 | 0.758 |
LYN |
0.706 | 0.022 | 3 | 0.496 |
TEC |
0.706 | -0.013 | -1 | 0.756 |
ROS1 |
0.705 | -0.185 | 3 | 0.537 |
MERTK |
0.705 | -0.018 | 3 | 0.554 |
JAK2 |
0.705 | -0.197 | 1 | 0.699 |
DDR1 |
0.705 | -0.154 | 4 | 0.699 |
NEK3 |
0.705 | -0.327 | 1 | 0.674 |
STLK3 |
0.705 | -0.161 | 1 | 0.641 |
KIT |
0.704 | -0.076 | 3 | 0.549 |
FLT1 |
0.704 | -0.003 | -1 | 0.894 |
ASK1 |
0.704 | -0.252 | 1 | 0.651 |
SRC |
0.704 | 0.040 | -1 | 0.826 |
NTRK1 |
0.704 | -0.034 | -1 | 0.850 |
HASPIN |
0.704 | -0.135 | -1 | 0.602 |
EPHA8 |
0.703 | 0.043 | -1 | 0.868 |
BMX |
0.703 | -0.020 | -1 | 0.736 |
FLT3 |
0.703 | -0.111 | 3 | 0.548 |
BUB1 |
0.703 | -0.171 | -5 | 0.660 |
ROCK1 |
0.703 | -0.122 | -3 | 0.642 |
LIMK2_TYR |
0.703 | -0.240 | -3 | 0.781 |
MYO3B |
0.703 | -0.223 | 2 | 0.766 |
LIMK1_TYR |
0.702 | -0.294 | 2 | 0.809 |
CRIK |
0.702 | -0.093 | -3 | 0.580 |
PKG1 |
0.702 | -0.137 | -2 | 0.525 |
EPHA3 |
0.702 | -0.026 | 2 | 0.729 |
FGFR3 |
0.702 | -0.022 | 3 | 0.543 |
MYO3A |
0.702 | -0.221 | 1 | 0.677 |
MST1R |
0.701 | -0.256 | 3 | 0.562 |
BTK |
0.701 | -0.110 | -1 | 0.777 |
FRK |
0.700 | -0.040 | -1 | 0.867 |
ERBB2 |
0.699 | -0.071 | 1 | 0.665 |
PTK6 |
0.699 | -0.083 | -1 | 0.748 |
FGFR1 |
0.699 | -0.125 | 3 | 0.544 |
MET |
0.698 | -0.083 | 3 | 0.538 |
FGFR4 |
0.698 | 0.033 | -1 | 0.817 |
PDGFRB |
0.698 | -0.175 | 3 | 0.561 |
INSR |
0.698 | -0.066 | 3 | 0.500 |
TNK2 |
0.698 | -0.153 | 3 | 0.519 |
TAO1 |
0.697 | -0.247 | 1 | 0.629 |
KDR |
0.697 | -0.139 | 3 | 0.532 |
NTRK3 |
0.697 | -0.044 | -1 | 0.808 |
LTK |
0.696 | -0.106 | 3 | 0.507 |
TEK |
0.696 | -0.163 | 3 | 0.503 |
AAK1 |
0.696 | -0.011 | 1 | 0.595 |
CK1G2 |
0.696 | -0.017 | -3 | 0.519 |
AXL |
0.695 | -0.140 | 3 | 0.549 |
PTK2B |
0.695 | -0.029 | -1 | 0.775 |
NTRK2 |
0.694 | -0.123 | 3 | 0.537 |
IGF1R |
0.694 | 0.001 | 3 | 0.456 |
ALK |
0.694 | -0.142 | 3 | 0.487 |
EPHA2 |
0.693 | 0.034 | -1 | 0.849 |
FLT4 |
0.692 | -0.113 | 3 | 0.533 |
NEK10_TYR |
0.692 | -0.169 | 1 | 0.605 |
ERBB4 |
0.692 | 0.024 | 1 | 0.606 |
MATK |
0.692 | -0.062 | -1 | 0.743 |
JAK1 |
0.691 | -0.184 | 1 | 0.640 |
CSK |
0.691 | -0.044 | 2 | 0.756 |
EPHA1 |
0.688 | -0.148 | 3 | 0.510 |
DDR2 |
0.686 | -0.091 | 3 | 0.507 |
WEE1_TYR |
0.686 | -0.171 | -1 | 0.736 |
PDGFRA |
0.684 | -0.294 | 3 | 0.555 |
YANK2 |
0.684 | -0.089 | 2 | 0.428 |
TNNI3K_TYR |
0.684 | -0.208 | 1 | 0.734 |
TNK1 |
0.679 | -0.289 | 3 | 0.544 |
FES |
0.669 | -0.094 | -1 | 0.716 |
ZAP70 |
0.669 | -0.022 | -1 | 0.722 |
MUSK |
0.667 | -0.184 | 1 | 0.582 |