Motif 1159 (n=137)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| H3BTX0 | None | S75 | ochoa | PAXIP1-associated glutamate-rich protein 1 | None |
| O00453 | LST1 | Y88 | ochoa | Leukocyte-specific transcript 1 protein (Protein B144) | Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. {ECO:0000269|PubMed:10706707, ECO:0000269|PubMed:11478849}. |
| O14618 | CCS | S267 | ochoa | Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) | Delivers copper to copper zinc superoxide dismutase (SOD1). |
| O15164 | TRIM24 | S1042 | ochoa | Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Also participates in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). {ECO:0000250, ECO:0000269|PubMed:16322096, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:21164480, ECO:0000269|PubMed:24820418, ECO:0000269|PubMed:32324863, ECO:0000269|PubMed:33724611}. |
| O15198 | SMAD9 | S458 | ochoa | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). |
| O43155 | FLRT2 | S651 | ochoa | Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2) | Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. {ECO:0000250|UniProtKB:Q8BLU0}. |
| O43353 | RIPK2 | S531 | ochoa | Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) | Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}. |
| O75385 | ULK1 | S1042 | psp | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75496 | GMNN | S201 | psp | Geminin | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}. |
| O95470 | SGPL1 | S559 | ochoa | Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). {ECO:0000250|UniProtKB:Q8R0X7, ECO:0000250|UniProtKB:Q9V7Y2, ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814, ECO:0000269|PubMed:28165339}. |
| O95633 | FSTL3 | S255 | ochoa | Follistatin-related protein 3 (Follistatin-like protein 3) (Follistatin-related gene protein) | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}. |
| P04075 | ALDOA | S356 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P09651 | HNRNPA1 | S362 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P09651 | HNRNPA1 | S363 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P09651 | HNRNPA1 | S364 | ochoa|psp | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed] | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}. |
| P0C0S8 | H2AC11 | T121 | ochoa | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P0DMV8 | HSPA1A | S633 | ochoa|psp | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P0DMV9 | HSPA1B | S633 | ochoa | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P11142 | HSPA8 | S637 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11142 | HSPA8 | S638 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11229 | CHRM1 | S451 | psp | Muscarinic acetylcholine receptor M1 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. |
| P12268 | IMPDH2 | S505 | ochoa | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II) | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269|PubMed:14766016, ECO:0000269|PubMed:7763314, ECO:0000269|PubMed:7903306}. |
| P15408 | FOSL2 | S317 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P16455 | MGMT | S199 | ochoa | Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) | Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |
| P17342 | NPR3 | S533 | ochoa | Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) | Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity). {ECO:0000250|UniProtKB:P70180}. |
| P19484 | TFEB | S467 | ochoa|psp | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396). In association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616). {ECO:0000250|UniProtKB:Q9R210, ECO:0000269|PubMed:1748288, ECO:0000269|PubMed:19556463, ECO:0000269|PubMed:2115126, ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23434374, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:27278822, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823, ECO:0000269|PubMed:36749723, ECO:0000269|PubMed:37079666}. |
| P20671 | H2AC7 | T121 | ochoa | Histone H2A type 1-D (Histone H2A.3) (Histone H2A/g) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P22626 | HNRNPA2B1 | S344 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P24723 | PRKCH | S675 | ochoa|psp | Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}. |
| P25942 | CD40 | S269 | ochoa | Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40) | Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). {ECO:0000250|UniProtKB:P27512, ECO:0000269|PubMed:31331973}. |
| P31943 | HNRNPH1 | S441 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
| P32239 | CCKBR | Y438 | psp | Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) | Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; FUNCTION: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism. |
| P32241 | VIPR1 | S448 | ochoa | Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}. |
| P32241 | VIPR1 | S449 | ochoa | Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}. |
| P36915 | GNL1 | Y599 | ochoa | Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) | Possible regulatory or functional link with the histocompatibility cluster. |
| P41440 | SLC19A1 | S583 | ochoa | Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1) | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31126740, PubMed:31511694, PubMed:36745868). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803, PubMed:36071163, PubMed:36265513, PubMed:36575193). Also mediates the import of antifolate drug methotrexate (PubMed:22554803, PubMed:36071163, PubMed:7615551, PubMed:7641195, PubMed:9767079). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803). {ECO:0000269|PubMed:10787414, ECO:0000269|PubMed:14609557, ECO:0000269|PubMed:15337749, ECO:0000269|PubMed:16115875, ECO:0000269|PubMed:22554803, ECO:0000269|PubMed:31126740, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:32276275, ECO:0000269|PubMed:36071163, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:36575193, ECO:0000269|PubMed:36745868, ECO:0000269|PubMed:7615551, ECO:0000269|PubMed:7641195, ECO:0000269|PubMed:7826387, ECO:0000269|PubMed:9041240, ECO:0000269|PubMed:9767079}. |
| P41587 | VIPR2 | S429 | ochoa | Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2 receptor) (VPAC2R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27 (PubMed:35477937, PubMed:8933357). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:7811244, PubMed:35477937, PubMed:8933357). May be coupled to phospholipase C. {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:7811244, ECO:0000269|PubMed:8933357}. |
| P46087 | NOP2 | S803 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P48730 | CSNK1D | S406 | ochoa | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P50281 | MMP14 | Y573 | psp | Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) | Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed:8015608). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed:22065321, PubMed:8015608). Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657, PubMed:22065321). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1 (PubMed:21572390). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (PubMed:35177851). {ECO:0000250|UniProtKB:P53690, ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:21572390, ECO:0000269|PubMed:22065321, ECO:0000269|PubMed:22330140, ECO:0000269|PubMed:35177851, ECO:0000269|PubMed:8015608}. |
| P50895 | BCAM | S621 | ochoa|psp | Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239) | Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466). {ECO:0000269|PubMed:15975931, ECO:0000269|PubMed:17158232, ECO:0000269|PubMed:23160466, ECO:0000269|PubMed:31413112, ECO:0000269|PubMed:9616226}. |
| P51991 | HNRNPA3 | S370 | ochoa | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}. |
| P52926 | HMGA2 | S101 | ochoa | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) | Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}. |
| P55042 | RRAD | S299 | ochoa|psp | GTP-binding protein RAD (RAD1) (Ras associated with diabetes) | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents (By similarity). Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (PubMed:18056528). {ECO:0000250|UniProtKB:O88667, ECO:0000269|PubMed:18056528}. |
| P55196 | AFDN | T1815 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55287 | CDH11 | S788 | ochoa | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546). {ECO:0000269|PubMed:33811546}. |
| P55735 | SEC13 | S313 | ochoa | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | Functions as a component of the nuclear pore complex (NPC) and the COPII coat (PubMed:8972206). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q9D1M0, ECO:0000269|PubMed:8972206}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}. |
| P56211 | ARPP19 | S104 | ochoa|psp | cAMP-regulated phosphoprotein 19 (ARPP-19) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:38123684}. |
| P84022 | SMAD3 | S416 | ochoa|psp | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}. |
| Q01954 | BNC1 | S985 | ochoa | Zinc finger protein basonuclin-1 | Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909). May also play a role in the early development of embryos (By similarity). {ECO:0000250|UniProtKB:O35914, ECO:0000269|PubMed:30010909, ECO:0000269|PubMed:8034748}. |
| Q13015 | MLLT11 | S81 | ochoa | Protein AF1q | Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269|PubMed:26079538}. |
| Q13526 | PIN1 | S154 | ochoa | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) | Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:21497122, PubMed:23623683, PubMed:29686383). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (PubMed:26942675). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:29686383}. |
| Q13557 | CAMK2D | S490 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}. |
| Q13610 | PWP1 | S492 | ochoa | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}. |
| Q13610 | PWP1 | S494 | ochoa | Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502) | Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). {ECO:0000269|PubMed:29065309}. |
| Q13835 | PKP1 | S739 | ochoa | Plakophilin-1 (Band 6 protein) (B6P) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250|UniProtKB:P97350, ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:20156963, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:23444369, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9326952}. |
| Q13882 | PTK6 | S443 | ochoa | Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) | Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Phosphorylates the GTPase-activating protein ARAP1 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation (PubMed:20554524). Also associates with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. {ECO:0000269|PubMed:20554524}.; FUNCTION: [Isoform 2]: Inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins. |
| Q14011 | CIRBP | S163 | ochoa | Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}. |
| Q14011 | CIRBP | Y164 | ochoa | Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}. |
| Q14249 | ENDOG | S288 | psp | Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-) | Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (PubMed:25355512). The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity). Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (By similarity). Promotes conservative recombination when the DNA is 5hmC-modified (PubMed:25355512). Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (PubMed:33473107). GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (PubMed:33473107). Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (PubMed:29719607). {ECO:0000250|UniProtKB:O08600, ECO:0000269|PubMed:25355512, ECO:0000269|PubMed:29719607, ECO:0000269|PubMed:33473107}. |
| Q15743 | GPR68 | S356 | ochoa | G-protein coupled receptor 68 (G-protein coupled receptor 12A) (GPR12A) (Ovarian cancer G-protein coupled receptor 1) (OGR-1) | Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed:33478938, PubMed:39753132). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:29677517, PubMed:39753132). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:29677517, PubMed:39753132). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed:29677517, PubMed:30471999). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed:29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity). {ECO:0000250|UniProtKB:Q8BFQ3, ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:29677517, ECO:0000269|PubMed:30471999, ECO:0000269|PubMed:32865988, ECO:0000269|PubMed:33478938, ECO:0000269|PubMed:39753132}. |
| Q15758 | SLC1A5 | T532 | ochoa | Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). {ECO:0000250|UniProtKB:D3ZJ25, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:17094966, ECO:0000269|PubMed:23492904, ECO:0000269|PubMed:23756778, ECO:0000269|PubMed:24953180, ECO:0000269|PubMed:26492990, ECO:0000269|PubMed:29872227, ECO:0000269|PubMed:32733894, ECO:0000269|PubMed:34741534, ECO:0000269|PubMed:8702519}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. {ECO:0000269|PubMed:10051606, ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. {ECO:0000269|PubMed:10196349}.; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. {ECO:0000269|PubMed:10196349}. |
| Q15773 | MLF2 | S240 | ochoa | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | None |
| Q15796 | SMAD2 | S458 | ochoa | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q15797 | SMAD1 | S456 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q16559 | TAL2 | S100 | psp | T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19) | None |
| Q32P44 | EML3 | S887 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q3YBR2 | TBRG1 | S402 | ochoa | Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2) | Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269|PubMed:17110379}. |
| Q4G0F5 | VPS26B | S327 | ochoa | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). {ECO:0000250|UniProtKB:O75436, ECO:0000250|UniProtKB:Q8C0E2}. |
| Q5FWE3 | PRRT3 | S975 | ochoa | Proline-rich transmembrane protein 3 | None |
| Q5ZPR3 | CD276 | S525 | ochoa | CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}. |
| Q66GS9 | CEP135 | S1132 | ochoa | Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) | Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27477386}. |
| Q68DH5 | LMBRD2 | S687 | ochoa | G-protein coupled receptor-associated protein LMBRD2 (LMBR1 domain-containing protein 2) | Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway (PubMed:28388415). May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1 (Probable). {ECO:0000269|PubMed:28388415, ECO:0000305|PubMed:28388415}. |
| Q68E01 | INTS3 | S1035 | psp | Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS3 is involved in the post-termination step: INTS3 binds INTS7 in the open conformation of integrator complex and prevents the rebinding of Pol II to the integrator after termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:38570683}.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
| Q6FI13 | H2AC18 | T121 | ochoa | Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q6P1X5 | TAF2 | S1191 | ochoa | Transcription initiation factor TFIID subunit 2 (150 kDa cofactor of initiator function) (RNA polymerase II TBP-associated factor subunit B) (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (TAFII150) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:9418870, PubMed:9774672). TAF2 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF1 (PubMed:33795473, PubMed:9774672). {ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9418870, ECO:0000269|PubMed:9774672}. |
| Q6P597 | KLC3 | S495 | ochoa | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). {ECO:0000250|UniProtKB:Q91W40}. |
| Q6P996 | PDXDC1 | S779 | ochoa | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | None |
| Q6PHR2 | ULK3 | S464 | ochoa | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20643644}. |
| Q6PJG9 | LRFN4 | S626 | ochoa | Leucine-rich repeat and fibronectin type-III domain-containing protein 4 | Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}. |
| Q6WCQ1 | MPRIP | S1016 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZV89 | SH2D5 | S415 | ochoa | SH2 domain-containing protein 5 | May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. {ECO:0000250|UniProtKB:Q8JZW5}. |
| Q7L1Q6 | BZW1 | S411 | ochoa | eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf) | Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015). {ECO:0000269|PubMed:11524015, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}. |
| Q7L5D6 | GET4 | S319 | ochoa | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}. |
| Q86UE8 | TLK2 | S763 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86V88 | MDP1 | S167 | ochoa | Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) | Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. {ECO:0000250}. |
| Q86V88 | MDP1 | S168 | ochoa | Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) | Magnesium-dependent phosphatase which may act as a tyrosine phosphatase. {ECO:0000250}. |
| Q86VP6 | CAND1 | S1221 | ochoa | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}. |
| Q86Z20 | CCDC125 | S502 | ochoa | Coiled-coil domain-containing protein 125 (Protein kenae) | May be involved in the regulation of cell migration. {ECO:0000269|PubMed:19787194}. |
| Q8IZK6 | MCOLN2 | S558 | ochoa | Mucolipin-2 (Transient receptor potential channel mucolipin 2) (TRPML2) | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19885840, PubMed:19940139). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Also functions as a Fe(2+) permeable channel (By similarity). {ECO:0000250|UniProtKB:Q8K595, ECO:0000269|PubMed:17662026, ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:19940139, ECO:0000305}. |
| Q8NBR0 | TP53I13 | S385 | ochoa | Tumor protein p53-inducible protein 13 (Damage-stimulated cytoplasmic protein 1) | May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed. {ECO:0000269|PubMed:14767535}. |
| Q8WUH2 | TGFBRAP1 | S852 | ochoa | Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1) | Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. {ECO:0000269|PubMed:11278302, ECO:0000269|PubMed:9545258}.; FUNCTION: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (PubMed:25266290). {ECO:0000269|PubMed:25266290, ECO:0000305|PubMed:25266290}. |
| Q8WUY1 | THEM6 | S199 | ochoa | Protein THEM6 (Mesenchymal stem cell protein DSCD75) (Thioesterase superfamily member 6) | None |
| Q8WWN9 | IPCEF1 | S429 | ochoa | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}. |
| Q93077 | H2AC6 | T121 | ochoa | Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96BH1 | RNF25 | S450 | ochoa | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951216). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (PubMed:36638793). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (PubMed:36638793, PubMed:37651229). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (PubMed:12748188). {ECO:0000250|UniProtKB:Q9QZR0, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951216}. |
| Q96CW6 | SLC7A6OS | Y300 | ochoa | Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript) | Directs RNA polymerase II nuclear import. {ECO:0000250}. |
| Q96DX7 | TRIM44 | S336 | ochoa | Tripartite motif-containing protein 44 (Protein DIPB) | May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807). {ECO:0000250, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:26394807}. |
| Q96EH3 | MALSU1 | S225 | ochoa | Mitochondrial assembly of ribosomal large subunit protein 1 | Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548). May function as a ribosomal silencing factor (Probable). {ECO:0000269|PubMed:22238375, ECO:0000269|PubMed:22238376, ECO:0000269|PubMed:23171548, ECO:0000305|PubMed:22829778, ECO:0000305|PubMed:28892042}. |
| Q96EQ0 | SGTB | S295 | ochoa | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250}. |
| Q96QR8 | PURB | S304 | ochoa | Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) | Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (By similarity). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250|UniProtKB:O35295, ECO:0000250|UniProtKB:Q68A21, ECO:0000269|PubMed:1448097}. |
| Q99956 | DUSP9 | S375 | ochoa | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | Inactivates MAP kinases. Has a specificity for the ERK family. |
| Q9BTK6 | PAGR1 | S245 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9BWG4 | SSBP4 | S376 | ochoa | Single-stranded DNA-binding protein 4 | None |
| Q9BXM9 | FSD1L | S522 | ochoa | FSD1-like protein (Coiled-coil domain-containing protein 10) (FSD1 N-terminal-like protein) | None |
| Q9BYI3 | HYCC1 | S513 | ochoa | Hyccin (Down-regulated by CTNNB1 protein A) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269|PubMed:16951682, ECO:0000269|PubMed:26571211, ECO:0000305|PubMed:10910037}. |
| Q9BZQ8 | NIBAN1 | S920 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
| Q9GZM8 | NDEL1 | S336 | ochoa | Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1) | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Plays a role, together with DISC1, in the regulation of neurite outgrowth (By similarity). May act as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709). {ECO:0000250|UniProtKB:Q78PB6, ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:34793709}. |
| Q9HCJ2 | LRRC4C | S631 | psp | Leucine-rich repeat-containing protein 4C (Netrin-G1 ligand) (NGL-1) | May promote neurite outgrowth of developing thalamic neurons. {ECO:0000269|PubMed:14595443}. |
| Q9NQP4 | PFDN4 | S125 | ochoa | Prefoldin subunit 4 (Protein C-1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q9NQS7 | INCENP | S909 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NRA8 | EIF4ENIF1 | S977 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NRZ9 | HELLS | S829 | ochoa | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). {ECO:0000250|UniProtKB:Q60848}. |
| Q9NT99 | LRRC4B | S704 | ochoa | Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3) | Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). {ECO:0000250}. |
| Q9NVM1 | EVA1B | T156 | ochoa | Protein eva-1 homolog B (Protein FAM176B) | None |
| Q9NXD2 | MTMR10 | S769 | ochoa | Myotubularin-related protein 10 (Inactive phosphatidylinositol 3-phosphatase 10) | None |
| Q9NZJ7 | MTCH1 | S381 | ochoa | Mitochondrial carrier homolog 1 (Presenilin-associated protein) | Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (By similarity). Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). May play a role in apoptosis (PubMed:12377771). {ECO:0000250|UniProtKB:Q9Y6C9, ECO:0000269|PubMed:12377771, ECO:0000269|PubMed:36264797}. |
| Q9NZJ7 | MTCH1 | S382 | ochoa | Mitochondrial carrier homolog 1 (Presenilin-associated protein) | Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (By similarity). Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). May play a role in apoptosis (PubMed:12377771). {ECO:0000250|UniProtKB:Q9Y6C9, ECO:0000269|PubMed:12377771, ECO:0000269|PubMed:36264797}. |
| Q9UGP4 | LIMD1 | S668 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UJC3 | HOOK1 | S719 | ochoa | Protein Hook homolog 1 (h-hook1) (hHK1) | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). {ECO:0000250|UniProtKB:Q8BIL5, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:32073997}. |
| Q9UJX2 | CDC23 | S588 | ochoa | Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9ULD2 | MTUS1 | S1261 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9UN79 | SOX13 | S613 | ochoa | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}. |
| Q9UPN9 | TRIM33 | S1119 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9Y216 | MTMR7 | S652 | ochoa | Phosphatidylinositol-3-phosphate phosphatase MTMR7 (EC 3.1.3.64) (Inositol 1,3-bisphosphate phosphatase) (Myotubularin-related protein 7) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3-bisphosphate (Ins(1,3)P2). {ECO:0000250|UniProtKB:Q9Z2C9}. |
| Q9Y289 | SLC5A6 | S626 | ochoa | Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6) | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed:21570947, PubMed:22015582, PubMed:25809983, PubMed:25971966, PubMed:27904971, PubMed:28052864, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983). {ECO:0000250|UniProtKB:Q5U4D8, ECO:0000269|PubMed:10329687, ECO:0000269|PubMed:15561972, ECO:0000269|PubMed:19211916, ECO:0000269|PubMed:20980265, ECO:0000269|PubMed:21570947, ECO:0000269|PubMed:22015582, ECO:0000269|PubMed:25809983, ECO:0000269|PubMed:25971966, ECO:0000269|PubMed:27904971, ECO:0000269|PubMed:28052864, ECO:0000269|PubMed:31754459}. |
| Q9Y597 | KCTD3 | S806 | ochoa | BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) | Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) up-regulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. {ECO:0000250|UniProtKB:Q8BFX3}. |
| Q9Y5S9 | RBM8A | S166 | psp | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. The MAGOH-RBM8A heterodimer is a component of the nonsense mediated decay (NMD) pathway. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly. {ECO:0000269|PubMed:12121612, ECO:0000269|PubMed:12718880, ECO:0000269|PubMed:12730685, ECO:0000269|PubMed:16209946, ECO:0000269|PubMed:19409878, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| Q9Y5U2 | TSSC4 | S320 | ochoa | U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) | Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}. |
| Q9Y653 | ADGRG1 | S684 | ochoa | Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: Adhesion G-protein coupled receptor G1, N-terminal fragment (ADGRG1 N-terminal fragment) (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); Adhesion G-protein coupled receptor G1, C-terminal fragment (ADGRG1 C-terminal fragment) (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)] | Adhesion G-protein coupled receptor (aGPCR) for steroid hormone 17alpha-hydroxypregnenolone (17-OH), which is involved in cell adhesion and cell-cell interactions (PubMed:39389061). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:28874577, PubMed:35418682, PubMed:39389061). ADGRG1 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases (PubMed:22238662, PubMed:28424266, PubMed:35418682, PubMed:39389061). Acts as a potent suppressor of ferroptosis: binding to 17-OH-binding initiates signaling that down-regulates CD36 and alleviates ferroptosis-induced liver injury (By similarity). Ligand-binding also induces cell adhesion activity via association with proteins such as collagen III/COL3A1 and TGM2 (By similarity). Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells (By similarity). Involved in cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination: association with COL3A1 in the developing brain inhibits neuronal migration via activation of the RhoA pathway (PubMed:24531968). Together with TGM2, acts as a regulator of myelination and myelin repair in oligodendrocyte precursor cells (By similarity). Acts as a hemostatic sensor of shear force: G protein-coupled receptor signaling is activated in response to shear force in platelets, promoting G(13) G protein signaling, and platelet shape change and aggregation in a COL3A1-dependent manner (PubMed:33097663). Acts as an inhibitor of VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:19572147, PubMed:21724588). Plays a role in the maintenance of hematopoietic stem cells in bone marrow niche (By similarity). Plays an essential role in testis development (By similarity). {ECO:0000250|UniProtKB:Q8K209, ECO:0000269|PubMed:16757564, ECO:0000269|PubMed:19572147, ECO:0000269|PubMed:21724588, ECO:0000269|PubMed:22238662, ECO:0000269|PubMed:24531968, ECO:0000269|PubMed:28424266, ECO:0000269|PubMed:28874577, ECO:0000269|PubMed:33097663, ECO:0000269|PubMed:35418682, ECO:0000269|PubMed:39389061}. |
| Q9Y6V7 | DDX49 | S474 | ochoa | Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49) | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including the regulation of mRNA export and the levels of pre-ribosomal RNA. Regulates the stability and synthesis of pre-ribosomal RNA and thereby regulates cell proliferation (PubMed:29618122). Also possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). {ECO:0000269|PubMed:29618122, ECO:0000269|PubMed:36298642}. |
| P09972 | ALDOC | S356 | Sugiyama | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P30043 | BLVRB | S198 | Sugiyama | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.-) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (S-nitroso-CoA-assisted nitrosyltransferase) (SNO-CoA-assisted nitrosyltransferase) (EC 2.6.99.-) | Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:10620517, PubMed:18241201, PubMed:27207795, PubMed:38056462, PubMed:7929092). Promotes fetal heme degradation during development (PubMed:10858451, PubMed:18241201, PubMed:7929092). Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling (PubMed:27207795, PubMed:29500232, PubMed:38056462). Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone) (PubMed:10620517, PubMed:18241201, PubMed:7929092). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver (PubMed:10858451, PubMed:18241201, PubMed:7929092). Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult (PubMed:10858451, PubMed:18241201, PubMed:7929092). Does not reduce bilirubin IXalpha (PubMed:10858451, PubMed:18241201, PubMed:7929092). Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH (PubMed:10620517). Acts as a protein nitrosyltransferase by catalyzing nitrosylation of cysteine residues of target proteins, such as HMOX2, INSR and IRS1 (PubMed:38056462). S-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate (PubMed:38056462). Inhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition (PubMed:38056462). {ECO:0000269|PubMed:10620517, ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:18241201, ECO:0000269|PubMed:27207795, ECO:0000269|PubMed:29500232, ECO:0000269|PubMed:38056462, ECO:0000269|PubMed:7929092}. |
| O14757 | CHEK1 | S467 | Sugiyama | Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}. |
| Q9UBQ5 | EIF3K | S209 | Sugiyama | Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (Muscle-specific gene M9 protein) (PLAC-24) (eIF-3 p25) (eIF-3 p28) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q8TDU6 | GPBAR1 | S321 | PSP | G-protein coupled bile acid receptor 1 (G-protein coupled receptor GPCR19) (hGPCR19) (Membrane-type receptor for bile acids) (M-BAR) (hBG37) (BG37) | Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. {ECO:0000269|PubMed:12419312, ECO:0000269|PubMed:12524422}. |
| P30044 | PRDX5 | S205 | Sugiyama | Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371571 | HSF1-dependent transactivation | 1.332268e-15 | 14.875 |
| R-HSA-3371568 | Attenuation phase | 1.998401e-15 | 14.699 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 7.381318e-12 | 11.132 |
| R-HSA-3371556 | Cellular response to heat stress | 5.842327e-12 | 11.233 |
| R-HSA-3371511 | HSF1 activation | 1.993827e-11 | 10.700 |
| R-HSA-2262752 | Cellular responses to stress | 2.074111e-06 | 5.683 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.852697e-06 | 5.233 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.160059e-05 | 4.936 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.265260e-05 | 4.898 |
| R-HSA-5689901 | Metalloprotease DUBs | 1.637919e-05 | 4.786 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.505504e-05 | 4.601 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.174163e-05 | 4.379 |
| R-HSA-418990 | Adherens junctions interactions | 1.107009e-04 | 3.956 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 2.270747e-04 | 3.644 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 4.012559e-04 | 3.397 |
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 4.012559e-04 | 3.397 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 4.012559e-04 | 3.397 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.111121e-04 | 3.507 |
| R-HSA-5334118 | DNA methylation | 3.878999e-04 | 3.411 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.822146e-04 | 3.418 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.111121e-04 | 3.507 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.487334e-04 | 3.458 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.514067e-04 | 3.600 |
| R-HSA-421270 | Cell-cell junction organization | 3.106595e-04 | 3.508 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 5.271913e-04 | 3.278 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.132638e-04 | 3.290 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 5.806167e-04 | 3.236 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.716002e-04 | 3.243 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 6.136704e-04 | 3.212 |
| R-HSA-446728 | Cell junction organization | 6.458576e-04 | 3.190 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 6.988175e-04 | 3.156 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 6.988175e-04 | 3.156 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 8.331114e-04 | 3.079 |
| R-HSA-1502540 | Signaling by Activin | 8.583150e-04 | 3.066 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 9.066545e-04 | 3.043 |
| R-HSA-110331 | Cleavage of the damaged purine | 9.066545e-04 | 3.043 |
| R-HSA-73927 | Depurination | 9.846546e-04 | 3.007 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.154605e-03 | 2.938 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.154605e-03 | 2.938 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.108832e-03 | 2.955 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.173057e-03 | 2.931 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.246846e-03 | 2.904 |
| R-HSA-69306 | DNA Replication | 1.392642e-03 | 2.856 |
| R-HSA-5689603 | UCH proteinases | 1.372838e-03 | 2.862 |
| R-HSA-5688426 | Deubiquitination | 1.423735e-03 | 2.847 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.246846e-03 | 2.904 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 1.446577e-03 | 2.840 |
| R-HSA-73928 | Depyrimidination | 1.446577e-03 | 2.840 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 1.575107e-03 | 2.803 |
| R-HSA-9710421 | Defective pyroptosis | 1.554356e-03 | 2.808 |
| R-HSA-1500931 | Cell-Cell communication | 1.579080e-03 | 2.802 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 1.670662e-03 | 2.777 |
| R-HSA-774815 | Nucleosome assembly | 1.786458e-03 | 2.748 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.786458e-03 | 2.748 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.911065e-03 | 2.719 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 1.852109e-03 | 2.732 |
| R-HSA-68875 | Mitotic Prophase | 1.956547e-03 | 2.709 |
| R-HSA-68886 | M Phase | 1.835085e-03 | 2.736 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 2.130511e-03 | 2.672 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 2.130511e-03 | 2.672 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 2.765349e-03 | 2.558 |
| R-HSA-912446 | Meiotic recombination | 2.625297e-03 | 2.581 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.787354e-03 | 2.555 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.956135e-03 | 2.529 |
| R-HSA-1221632 | Meiotic synapsis | 2.956135e-03 | 2.529 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 3.478079e-03 | 2.459 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 3.478079e-03 | 2.459 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.131774e-03 | 2.504 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.905565e-03 | 2.408 |
| R-HSA-8849473 | PTK6 Expression | 4.267179e-03 | 2.370 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 4.337024e-03 | 2.363 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.407657e-03 | 2.356 |
| R-HSA-3214847 | HATs acetylate histones | 4.342116e-03 | 2.362 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 4.337024e-03 | 2.363 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.660668e-03 | 2.332 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.799547e-03 | 2.319 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.412135e-03 | 2.267 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.412135e-03 | 2.267 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 6.017533e-03 | 2.221 |
| R-HSA-72172 | mRNA Splicing | 6.083834e-03 | 2.216 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 6.383245e-03 | 2.195 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 5.821708e-03 | 2.235 |
| R-HSA-211000 | Gene Silencing by RNA | 6.011648e-03 | 2.221 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.979641e-03 | 2.156 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.979641e-03 | 2.156 |
| R-HSA-9762292 | Regulation of CDH11 function | 7.077814e-03 | 2.150 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 7.077814e-03 | 2.150 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 7.291188e-03 | 2.137 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.291188e-03 | 2.137 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 8.466613e-03 | 2.072 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 8.986660e-03 | 2.046 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.051436e-02 | 1.978 |
| R-HSA-73864 | RNA Polymerase I Transcription | 9.731022e-03 | 2.012 |
| R-HSA-1640170 | Cell Cycle | 1.056524e-02 | 1.976 |
| R-HSA-977225 | Amyloid fiber formation | 1.092087e-02 | 1.962 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.157035e-02 | 1.937 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.157035e-02 | 1.937 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.157035e-02 | 1.937 |
| R-HSA-9796292 | Formation of axial mesoderm | 1.180596e-02 | 1.928 |
| R-HSA-162582 | Signal Transduction | 1.210630e-02 | 1.917 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.220086e-02 | 1.914 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.264796e-02 | 1.898 |
| R-HSA-1500620 | Meiosis | 1.264796e-02 | 1.898 |
| R-HSA-2559583 | Cellular Senescence | 1.272403e-02 | 1.895 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.546559e-02 | 1.811 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 1.607172e-02 | 1.794 |
| R-HSA-73884 | Base Excision Repair | 1.555058e-02 | 1.808 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.454062e-02 | 1.837 |
| R-HSA-9609690 | HCMV Early Events | 1.790647e-02 | 1.747 |
| R-HSA-5657655 | MGMT-mediated DNA damage reversal | 1.894628e-02 | 1.722 |
| R-HSA-5619110 | Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) | 1.894628e-02 | 1.722 |
| R-HSA-157579 | Telomere Maintenance | 2.063701e-02 | 1.685 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.253432e-02 | 1.647 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.385643e-02 | 1.622 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.385643e-02 | 1.622 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.404266e-02 | 1.619 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 2.404266e-02 | 1.619 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.429771e-02 | 1.614 |
| R-HSA-1181150 | Signaling by NODAL | 2.429771e-02 | 1.614 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.550009e-02 | 1.593 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.550009e-02 | 1.593 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.799331e-02 | 1.553 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.799331e-02 | 1.553 |
| R-HSA-6803529 | FGFR2 alternative splicing | 2.992035e-02 | 1.524 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.355571e-02 | 1.474 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.799331e-02 | 1.553 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 2.992035e-02 | 1.524 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.799331e-02 | 1.553 |
| R-HSA-9610379 | HCMV Late Events | 2.718942e-02 | 1.566 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 3.276847e-02 | 1.485 |
| R-HSA-9620244 | Long-term potentiation | 3.600462e-02 | 1.444 |
| R-HSA-9839394 | TGFBR3 expression | 3.600462e-02 | 1.444 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.618778e-02 | 1.441 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.710082e-02 | 1.431 |
| R-HSA-2473224 | Antagonism of Activin by Follistatin | 3.753588e-02 | 1.426 |
| R-HSA-201451 | Signaling by BMP | 4.030226e-02 | 1.395 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 4.030226e-02 | 1.395 |
| R-HSA-73886 | Chromosome Maintenance | 4.149931e-02 | 1.382 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.338895e-02 | 1.363 |
| R-HSA-420092 | Glucagon-type ligand receptors | 4.478297e-02 | 1.349 |
| R-HSA-4839726 | Chromatin organization | 4.558230e-02 | 1.341 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.561387e-02 | 1.341 |
| R-HSA-9609646 | HCMV Infection | 4.625785e-02 | 1.335 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.023626e-02 | 1.299 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 5.577548e-02 | 1.254 |
| R-HSA-8849472 | PTK6 Down-Regulation | 6.476608e-02 | 1.189 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.215516e-02 | 1.207 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.215516e-02 | 1.207 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 6.476608e-02 | 1.189 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 6.699254e-02 | 1.174 |
| R-HSA-8849474 | PTK6 Activates STAT3 | 6.476608e-02 | 1.189 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 6.437246e-02 | 1.191 |
| R-HSA-390648 | Muscarinic acetylcholine receptors | 6.476608e-02 | 1.189 |
| R-HSA-68877 | Mitotic Prometaphase | 5.395159e-02 | 1.268 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.426028e-02 | 1.266 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.022172e-02 | 1.220 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 6.372982e-02 | 1.196 |
| R-HSA-189483 | Heme degradation | 5.673123e-02 | 1.246 |
| R-HSA-111933 | Calmodulin induced events | 6.437246e-02 | 1.191 |
| R-HSA-111997 | CaM pathway | 6.437246e-02 | 1.191 |
| R-HSA-9833482 | PKR-mediated signaling | 5.310114e-02 | 1.275 |
| R-HSA-1474165 | Reproduction | 5.248361e-02 | 1.280 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 7.367163e-02 | 1.133 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 7.367163e-02 | 1.133 |
| R-HSA-9652817 | Signaling by MAPK mutants | 7.367163e-02 | 1.133 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 7.367163e-02 | 1.133 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 8.060008e-02 | 1.094 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 8.060008e-02 | 1.094 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 8.249292e-02 | 1.084 |
| R-HSA-111996 | Ca-dependent events | 8.341694e-02 | 1.079 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.582244e-02 | 1.066 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 8.626362e-02 | 1.064 |
| R-HSA-190236 | Signaling by FGFR | 8.764134e-02 | 1.057 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 8.913932e-02 | 1.050 |
| R-HSA-6798695 | Neutrophil degranulation | 8.943719e-02 | 1.048 |
| R-HSA-447041 | CHL1 interactions | 9.123074e-02 | 1.040 |
| R-HSA-70171 | Glycolysis | 9.132780e-02 | 1.039 |
| R-HSA-1489509 | DAG and IP3 signaling | 9.204322e-02 | 1.036 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 9.497455e-02 | 1.022 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.824035e-02 | 1.008 |
| R-HSA-9613354 | Lipophagy | 1.084591e-01 | 0.965 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.582213e-01 | 0.801 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.741875e-01 | 0.759 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.741875e-01 | 0.759 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.052230e-01 | 0.688 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.203033e-01 | 0.657 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.423924e-01 | 0.615 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.847224e-01 | 0.546 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.482951e-01 | 0.829 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.482951e-01 | 0.829 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.915453e-01 | 0.535 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.582480e-01 | 0.801 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.983035e-01 | 0.525 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.983035e-01 | 0.525 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.819175e-01 | 0.740 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.819175e-01 | 0.740 |
| R-HSA-380287 | Centrosome maturation | 1.887759e-01 | 0.724 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.130332e-01 | 0.672 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.375688e-01 | 0.624 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.446105e-01 | 0.612 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 9.988589e-02 | 1.000 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 1.419484e-01 | 0.848 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 1.820575e-01 | 0.740 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.482951e-01 | 0.829 |
| R-HSA-8848021 | Signaling by PTK6 | 1.482951e-01 | 0.829 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 1.898529e-01 | 0.722 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 2.638596e-01 | 0.579 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.323976e-01 | 0.634 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 2.052230e-01 | 0.688 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.084591e-01 | 0.965 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.501235e-01 | 0.824 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.820575e-01 | 0.740 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 1.975745e-01 | 0.704 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.778342e-01 | 0.556 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 1.975745e-01 | 0.704 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 1.898529e-01 | 0.722 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.975745e-01 | 0.704 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.127990e-01 | 0.672 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.717046e-01 | 0.765 |
| R-HSA-68882 | Mitotic Anaphase | 1.908549e-01 | 0.719 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 9.988589e-02 | 1.000 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.336951e-01 | 0.874 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.820575e-01 | 0.740 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 2.203033e-01 | 0.657 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 2.423924e-01 | 0.615 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.915453e-01 | 0.535 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.983035e-01 | 0.525 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.200213e-01 | 0.658 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.927820e-01 | 0.715 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.401474e-01 | 0.853 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 1.169513e-01 | 0.932 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.662424e-01 | 0.779 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.915453e-01 | 0.535 |
| R-HSA-1592389 | Activation of Matrix Metalloproteinases | 2.847224e-01 | 0.546 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.482951e-01 | 0.829 |
| R-HSA-399719 | Trafficking of AMPA receptors | 2.983035e-01 | 0.525 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 2.638596e-01 | 0.579 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.939893e-01 | 0.532 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.501235e-01 | 0.824 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 2.277365e-01 | 0.643 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.915453e-01 | 0.535 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 1.106897e-01 | 0.956 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.819175e-01 | 0.740 |
| R-HSA-8953854 | Metabolism of RNA | 1.198727e-01 | 0.921 |
| R-HSA-9758941 | Gastrulation | 2.153441e-01 | 0.667 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.292860e-01 | 0.888 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.340520e-01 | 0.631 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.103938e-01 | 0.677 |
| R-HSA-74160 | Gene expression (Transcription) | 2.663430e-01 | 0.575 |
| R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | 1.501235e-01 | 0.824 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.741875e-01 | 0.759 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.983035e-01 | 0.525 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 2.235228e-01 | 0.651 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.582213e-01 | 0.801 |
| R-HSA-3295583 | TRP channels | 2.638596e-01 | 0.579 |
| R-HSA-416476 | G alpha (q) signalling events | 2.888749e-01 | 0.539 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.055766e-01 | 0.687 |
| R-HSA-6811555 | PI5P Regulates TP53 Acetylation | 1.501235e-01 | 0.824 |
| R-HSA-73942 | DNA Damage Reversal | 1.662424e-01 | 0.779 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.887759e-01 | 0.724 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.118732e-01 | 0.951 |
| R-HSA-9663891 | Selective autophagy | 2.375688e-01 | 0.624 |
| R-HSA-8939211 | ESR-mediated signaling | 2.325097e-01 | 0.634 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.591222e-01 | 0.798 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 1.419484e-01 | 0.848 |
| R-HSA-8876725 | Protein methylation | 1.662424e-01 | 0.779 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.052230e-01 | 0.688 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 2.203033e-01 | 0.657 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.915453e-01 | 0.535 |
| R-HSA-212436 | Generic Transcription Pathway | 2.459904e-01 | 0.609 |
| R-HSA-418555 | G alpha (s) signalling events | 2.736539e-01 | 0.563 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 9.988589e-02 | 1.000 |
| R-HSA-9845614 | Sphingolipid catabolism | 2.638596e-01 | 0.579 |
| R-HSA-70326 | Glucose metabolism | 1.314746e-01 | 0.881 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.834185e-01 | 0.548 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.165247e-01 | 0.664 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.060678e-01 | 0.686 |
| R-HSA-9754706 | Atorvastatin ADME | 1.741875e-01 | 0.759 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.350993e-01 | 0.629 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.009164e-01 | 0.996 |
| R-HSA-196780 | Biotin transport and metabolism | 1.662424e-01 | 0.779 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.662424e-01 | 0.779 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 2.567719e-01 | 0.590 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.785028e-01 | 0.748 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.719284e-01 | 0.566 |
| R-HSA-69242 | S Phase | 2.128693e-01 | 0.672 |
| R-HSA-9711123 | Cellular response to chemical stress | 1.435463e-01 | 0.843 |
| R-HSA-112043 | PLC beta mediated events | 1.417347e-01 | 0.849 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.785028e-01 | 0.748 |
| R-HSA-70263 | Gluconeogenesis | 1.009164e-01 | 0.996 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 2.638596e-01 | 0.579 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.429405e-01 | 0.615 |
| R-HSA-112040 | G-protein mediated events | 1.615933e-01 | 0.792 |
| R-HSA-189445 | Metabolism of porphyrins | 1.750983e-01 | 0.757 |
| R-HSA-1483255 | PI Metabolism | 2.939893e-01 | 0.532 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 2.446105e-01 | 0.612 |
| R-HSA-913531 | Interferon Signaling | 1.917399e-01 | 0.717 |
| R-HSA-73894 | DNA Repair | 1.583157e-01 | 0.800 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.134379e-01 | 0.945 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.134379e-01 | 0.945 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.549162e-01 | 0.810 |
| R-HSA-157118 | Signaling by NOTCH | 1.053859e-01 | 0.977 |
| R-HSA-195721 | Signaling by WNT | 1.900595e-01 | 0.721 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.922186e-01 | 0.716 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.340520e-01 | 0.631 |
| R-HSA-111885 | Opioid Signalling | 3.010254e-01 | 0.521 |
| R-HSA-9824446 | Viral Infection Pathways | 3.047374e-01 | 0.516 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.049976e-01 | 0.516 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.049976e-01 | 0.516 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.115576e-01 | 0.506 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 3.116283e-01 | 0.506 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 3.116283e-01 | 0.506 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.116283e-01 | 0.506 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.116283e-01 | 0.506 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.116283e-01 | 0.506 |
| R-HSA-9733709 | Cardiogenesis | 3.116283e-01 | 0.506 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.116283e-01 | 0.506 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.116283e-01 | 0.506 |
| R-HSA-159418 | Recycling of bile acids and salts | 3.116283e-01 | 0.506 |
| R-HSA-69239 | Synthesis of DNA | 3.150614e-01 | 0.502 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.177709e-01 | 0.498 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 3.181962e-01 | 0.497 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 3.181962e-01 | 0.497 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 3.181962e-01 | 0.497 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 3.181962e-01 | 0.497 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 3.215524e-01 | 0.493 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 3.247018e-01 | 0.489 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.247018e-01 | 0.489 |
| R-HSA-180746 | Nuclear import of Rev protein | 3.247018e-01 | 0.489 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.247018e-01 | 0.489 |
| R-HSA-5205647 | Mitophagy | 3.247018e-01 | 0.489 |
| R-HSA-5673000 | RAF activation | 3.247018e-01 | 0.489 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.311457e-01 | 0.480 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.311457e-01 | 0.480 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.311457e-01 | 0.480 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 3.311457e-01 | 0.480 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.325175e-01 | 0.478 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.375285e-01 | 0.472 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.375285e-01 | 0.472 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 3.438508e-01 | 0.464 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.438508e-01 | 0.464 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 3.438508e-01 | 0.464 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.438508e-01 | 0.464 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.501132e-01 | 0.456 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 3.501132e-01 | 0.456 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.501132e-01 | 0.456 |
| R-HSA-388396 | GPCR downstream signalling | 3.507757e-01 | 0.455 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.556883e-01 | 0.449 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.563161e-01 | 0.448 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.563161e-01 | 0.448 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.563161e-01 | 0.448 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 3.563161e-01 | 0.448 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.624603e-01 | 0.441 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 3.624603e-01 | 0.441 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.624603e-01 | 0.441 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.624603e-01 | 0.441 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.624603e-01 | 0.441 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.624603e-01 | 0.441 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.685462e-01 | 0.434 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 3.685462e-01 | 0.434 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.685462e-01 | 0.434 |
| R-HSA-167161 | HIV Transcription Initiation | 3.745743e-01 | 0.426 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 3.745743e-01 | 0.426 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 3.745743e-01 | 0.426 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.745743e-01 | 0.426 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.745743e-01 | 0.426 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 3.745743e-01 | 0.426 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.772506e-01 | 0.423 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 3.864596e-01 | 0.413 |
| R-HSA-8854214 | TBC/RABGAPs | 3.864596e-01 | 0.413 |
| R-HSA-1433557 | Signaling by SCF-KIT | 3.864596e-01 | 0.413 |
| R-HSA-69206 | G1/S Transition | 3.874070e-01 | 0.412 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 3.923179e-01 | 0.406 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.923179e-01 | 0.406 |
| R-HSA-69236 | G1 Phase | 3.923179e-01 | 0.406 |
| R-HSA-375280 | Amine ligand-binding receptors | 3.923179e-01 | 0.406 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 3.974911e-01 | 0.401 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 3.981205e-01 | 0.400 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.981205e-01 | 0.400 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.981205e-01 | 0.400 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.981205e-01 | 0.400 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.038681e-01 | 0.394 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.038681e-01 | 0.394 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.038681e-01 | 0.394 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.038681e-01 | 0.394 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.038681e-01 | 0.394 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.038681e-01 | 0.394 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.038681e-01 | 0.394 |
| R-HSA-75153 | Apoptotic execution phase | 4.038681e-01 | 0.394 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.040349e-01 | 0.394 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 4.064974e-01 | 0.391 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.095612e-01 | 0.388 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 4.095612e-01 | 0.388 |
| R-HSA-9909396 | Circadian clock | 4.141267e-01 | 0.383 |
| R-HSA-9748787 | Azathioprine ADME | 4.263183e-01 | 0.370 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.317983e-01 | 0.365 |
| R-HSA-72312 | rRNA processing | 4.337398e-01 | 0.363 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.372264e-01 | 0.359 |
| R-HSA-72187 | mRNA 3'-end processing | 4.372264e-01 | 0.359 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.426029e-01 | 0.354 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.426029e-01 | 0.354 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 4.426029e-01 | 0.354 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.426029e-01 | 0.354 |
| R-HSA-8956320 | Nucleotide biosynthesis | 4.426029e-01 | 0.354 |
| R-HSA-1632852 | Macroautophagy | 4.466969e-01 | 0.350 |
| R-HSA-72649 | Translation initiation complex formation | 4.479283e-01 | 0.349 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.479283e-01 | 0.349 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 4.530910e-01 | 0.344 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.530910e-01 | 0.344 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.532032e-01 | 0.344 |
| R-HSA-418597 | G alpha (z) signalling events | 4.532032e-01 | 0.344 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.584281e-01 | 0.339 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.584281e-01 | 0.339 |
| R-HSA-5578775 | Ion homeostasis | 4.584281e-01 | 0.339 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.584281e-01 | 0.339 |
| R-HSA-75893 | TNF signaling | 4.584281e-01 | 0.339 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.636033e-01 | 0.334 |
| R-HSA-372790 | Signaling by GPCR | 4.641736e-01 | 0.333 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.657529e-01 | 0.332 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.687294e-01 | 0.329 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.688915e-01 | 0.329 |
| R-HSA-166520 | Signaling by NTRKs | 4.720193e-01 | 0.326 |
| R-HSA-191859 | snRNP Assembly | 4.738068e-01 | 0.324 |
| R-HSA-194441 | Metabolism of non-coding RNA | 4.738068e-01 | 0.324 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 4.738068e-01 | 0.324 |
| R-HSA-983189 | Kinesins | 4.788360e-01 | 0.320 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.788360e-01 | 0.320 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 4.838175e-01 | 0.315 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 4.838175e-01 | 0.315 |
| R-HSA-1442490 | Collagen degradation | 4.838175e-01 | 0.315 |
| R-HSA-450294 | MAP kinase activation | 4.838175e-01 | 0.315 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.844199e-01 | 0.315 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 4.887516e-01 | 0.311 |
| R-HSA-6784531 | tRNA processing in the nucleus | 4.887516e-01 | 0.311 |
| R-HSA-73887 | Death Receptor Signaling | 4.905529e-01 | 0.309 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 4.936389e-01 | 0.307 |
| R-HSA-9612973 | Autophagy | 4.966404e-01 | 0.304 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 4.984798e-01 | 0.302 |
| R-HSA-936837 | Ion transport by P-type ATPases | 4.984798e-01 | 0.302 |
| R-HSA-162587 | HIV Life Cycle | 4.996669e-01 | 0.301 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.997310e-01 | 0.301 |
| R-HSA-112316 | Neuronal System | 5.029775e-01 | 0.298 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.032746e-01 | 0.298 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 5.127282e-01 | 0.290 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 5.127282e-01 | 0.290 |
| R-HSA-167172 | Transcription of the HIV genome | 5.173877e-01 | 0.286 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.265744e-01 | 0.279 |
| R-HSA-448424 | Interleukin-17 signaling | 5.265744e-01 | 0.279 |
| R-HSA-5619102 | SLC transporter disorders | 5.292876e-01 | 0.276 |
| R-HSA-500792 | GPCR ligand binding | 5.299091e-01 | 0.276 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.311023e-01 | 0.275 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.311023e-01 | 0.275 |
| R-HSA-5632684 | Hedgehog 'on' state | 5.311023e-01 | 0.275 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.311023e-01 | 0.275 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 5.355873e-01 | 0.271 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.355873e-01 | 0.271 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 5.408015e-01 | 0.267 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.444297e-01 | 0.264 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.444297e-01 | 0.264 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.444297e-01 | 0.264 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.444297e-01 | 0.264 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 5.444297e-01 | 0.264 |
| R-HSA-917937 | Iron uptake and transport | 5.487879e-01 | 0.261 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.549201e-01 | 0.256 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 5.616158e-01 | 0.251 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 5.629086e-01 | 0.250 |
| R-HSA-168255 | Influenza Infection | 5.659939e-01 | 0.247 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 5.687808e-01 | 0.245 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.699657e-01 | 0.244 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.699657e-01 | 0.244 |
| R-HSA-1280218 | Adaptive Immune System | 5.724212e-01 | 0.242 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.740812e-01 | 0.241 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 5.821952e-01 | 0.235 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.839844e-01 | 0.234 |
| R-HSA-69275 | G2/M Transition | 5.848967e-01 | 0.233 |
| R-HSA-449147 | Signaling by Interleukins | 5.862300e-01 | 0.232 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.901856e-01 | 0.229 |
| R-HSA-983712 | Ion channel transport | 5.928114e-01 | 0.227 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.940791e-01 | 0.226 |
| R-HSA-5617833 | Cilium Assembly | 5.954248e-01 | 0.225 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 5.979653e-01 | 0.223 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.006141e-01 | 0.221 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 6.018145e-01 | 0.221 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.131439e-01 | 0.212 |
| R-HSA-202424 | Downstream TCR signaling | 6.131439e-01 | 0.212 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.168487e-01 | 0.210 |
| R-HSA-391251 | Protein folding | 6.241529e-01 | 0.205 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 6.258136e-01 | 0.204 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.348507e-01 | 0.197 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 6.383489e-01 | 0.195 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.393836e-01 | 0.194 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.418138e-01 | 0.193 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.452458e-01 | 0.190 |
| R-HSA-9679506 | SARS-CoV Infections | 6.480888e-01 | 0.188 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.486451e-01 | 0.188 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 6.486451e-01 | 0.188 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 6.486451e-01 | 0.188 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 6.486451e-01 | 0.188 |
| R-HSA-597592 | Post-translational protein modification | 6.492592e-01 | 0.188 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 6.520120e-01 | 0.186 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.521021e-01 | 0.186 |
| R-HSA-9020702 | Interleukin-1 signaling | 6.586500e-01 | 0.181 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 6.651622e-01 | 0.177 |
| R-HSA-9748784 | Drug ADME | 6.658161e-01 | 0.177 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 6.683719e-01 | 0.175 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.746997e-01 | 0.171 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 6.839673e-01 | 0.165 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 6.839673e-01 | 0.165 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 6.839673e-01 | 0.165 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.839673e-01 | 0.165 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.841627e-01 | 0.165 |
| R-HSA-162906 | HIV Infection | 6.855723e-01 | 0.164 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 6.869978e-01 | 0.163 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 6.877078e-01 | 0.163 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.899995e-01 | 0.161 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.899995e-01 | 0.161 |
| R-HSA-202403 | TCR signaling | 6.899995e-01 | 0.161 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 6.899995e-01 | 0.161 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 6.919432e-01 | 0.160 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 6.959172e-01 | 0.157 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 6.959172e-01 | 0.157 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 6.988339e-01 | 0.156 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.017228e-01 | 0.154 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.017228e-01 | 0.154 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.045841e-01 | 0.152 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 7.074182e-01 | 0.150 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.074182e-01 | 0.150 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.130055e-01 | 0.147 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.130055e-01 | 0.147 |
| R-HSA-373760 | L1CAM interactions | 7.130055e-01 | 0.147 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.157593e-01 | 0.145 |
| R-HSA-5693538 | Homology Directed Repair | 7.184868e-01 | 0.144 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 7.211883e-01 | 0.142 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 7.211883e-01 | 0.142 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.211883e-01 | 0.142 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.260707e-01 | 0.139 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 7.291393e-01 | 0.137 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 7.291393e-01 | 0.137 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.343144e-01 | 0.134 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.343144e-01 | 0.134 |
| R-HSA-69481 | G2/M Checkpoints | 7.443717e-01 | 0.128 |
| R-HSA-114608 | Platelet degranulation | 7.443717e-01 | 0.128 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.449297e-01 | 0.128 |
| R-HSA-168256 | Immune System | 7.487903e-01 | 0.126 |
| R-HSA-5576891 | Cardiac conduction | 7.564130e-01 | 0.121 |
| R-HSA-9843745 | Adipogenesis | 7.564130e-01 | 0.121 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.587527e-01 | 0.120 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.587527e-01 | 0.120 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.610702e-01 | 0.119 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 7.653777e-01 | 0.116 |
| R-HSA-199991 | Membrane Trafficking | 7.705914e-01 | 0.113 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.723297e-01 | 0.112 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.737120e-01 | 0.111 |
| R-HSA-5368287 | Mitochondrial translation | 7.745175e-01 | 0.111 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.745175e-01 | 0.111 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 7.863788e-01 | 0.104 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.872126e-01 | 0.104 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 7.972476e-01 | 0.098 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.011286e-01 | 0.096 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 8.049358e-01 | 0.094 |
| R-HSA-1483257 | Phospholipid metabolism | 8.056429e-01 | 0.094 |
| R-HSA-9609507 | Protein localization | 8.068122e-01 | 0.093 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.068122e-01 | 0.093 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.105113e-01 | 0.091 |
| R-HSA-9711097 | Cellular response to starvation | 8.159284e-01 | 0.088 |
| R-HSA-877300 | Interferon gamma signaling | 8.176997e-01 | 0.087 |
| R-HSA-109581 | Apoptosis | 8.229126e-01 | 0.085 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.363682e-01 | 0.078 |
| R-HSA-72306 | tRNA processing | 8.376791e-01 | 0.077 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 8.384170e-01 | 0.077 |
| R-HSA-168249 | Innate Immune System | 8.397167e-01 | 0.076 |
| R-HSA-5663205 | Infectious disease | 8.449730e-01 | 0.073 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.453472e-01 | 0.073 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.609734e-01 | 0.065 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 8.630576e-01 | 0.064 |
| R-HSA-168898 | Toll-like Receptor Cascades | 8.675476e-01 | 0.062 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 8.701504e-01 | 0.060 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.786122e-01 | 0.056 |
| R-HSA-428157 | Sphingolipid metabolism | 8.797834e-01 | 0.056 |
| R-HSA-376176 | Signaling by ROBO receptors | 8.820923e-01 | 0.054 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.842325e-01 | 0.053 |
| R-HSA-5357801 | Programmed Cell Death | 8.854733e-01 | 0.053 |
| R-HSA-6805567 | Keratinization | 8.865788e-01 | 0.052 |
| R-HSA-397014 | Muscle contraction | 8.929924e-01 | 0.049 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.940257e-01 | 0.049 |
| R-HSA-8951664 | Neddylation | 9.019432e-01 | 0.045 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.022373e-01 | 0.045 |
| R-HSA-392499 | Metabolism of proteins | 9.054396e-01 | 0.043 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.092728e-01 | 0.041 |
| R-HSA-15869 | Metabolism of nucleotides | 9.152381e-01 | 0.038 |
| R-HSA-418594 | G alpha (i) signalling events | 9.178269e-01 | 0.037 |
| R-HSA-382551 | Transport of small molecules | 9.220528e-01 | 0.035 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.270271e-01 | 0.033 |
| R-HSA-72766 | Translation | 9.309819e-01 | 0.031 |
| R-HSA-1266738 | Developmental Biology | 9.462620e-01 | 0.024 |
| R-HSA-1643685 | Disease | 9.545794e-01 | 0.020 |
| R-HSA-8957322 | Metabolism of steroids | 9.640444e-01 | 0.016 |
| R-HSA-1474244 | Extracellular matrix organization | 9.664222e-01 | 0.015 |
| R-HSA-422475 | Axon guidance | 9.732635e-01 | 0.012 |
| R-HSA-9675108 | Nervous system development | 9.804124e-01 | 0.009 |
| R-HSA-109582 | Hemostasis | 9.844944e-01 | 0.007 |
| R-HSA-556833 | Metabolism of lipids | 9.997892e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
RSK2 |
0.850 | 0.455 | -3 | 0.881 |
PIM3 |
0.847 | 0.415 | -3 | 0.886 |
NDR2 |
0.846 | 0.341 | -3 | 0.854 |
RSK4 |
0.843 | 0.441 | -3 | 0.885 |
P90RSK |
0.843 | 0.435 | -3 | 0.886 |
PRKD1 |
0.842 | 0.397 | -3 | 0.840 |
PIM1 |
0.842 | 0.430 | -3 | 0.882 |
CLK3 |
0.842 | 0.290 | 1 | 0.778 |
SKMLCK |
0.841 | 0.368 | -2 | 0.837 |
PRKD2 |
0.841 | 0.414 | -3 | 0.854 |
COT |
0.839 | 0.183 | 2 | 0.832 |
SRPK1 |
0.839 | 0.372 | -3 | 0.885 |
CAMK1B |
0.838 | 0.394 | -3 | 0.846 |
RSK3 |
0.838 | 0.396 | -3 | 0.873 |
PKACB |
0.838 | 0.367 | -2 | 0.690 |
PRKX |
0.838 | 0.402 | -3 | 0.848 |
CLK2 |
0.837 | 0.407 | -3 | 0.887 |
MOS |
0.836 | 0.268 | 1 | 0.847 |
CDKL1 |
0.836 | 0.404 | -3 | 0.875 |
MAPKAPK2 |
0.836 | 0.385 | -3 | 0.857 |
MSK1 |
0.836 | 0.388 | -3 | 0.858 |
CDC7 |
0.835 | 0.170 | 1 | 0.833 |
HIPK4 |
0.834 | 0.303 | 1 | 0.727 |
PKACG |
0.833 | 0.308 | -2 | 0.760 |
NDR1 |
0.833 | 0.299 | -3 | 0.860 |
CAMK2A |
0.833 | 0.343 | 2 | 0.800 |
CDKL5 |
0.831 | 0.347 | -3 | 0.875 |
P70S6KB |
0.831 | 0.346 | -3 | 0.860 |
GRK1 |
0.830 | 0.213 | -2 | 0.809 |
CAMK2B |
0.830 | 0.291 | 2 | 0.791 |
AURC |
0.830 | 0.240 | -2 | 0.678 |
LATS2 |
0.829 | 0.221 | -5 | 0.677 |
MSK2 |
0.829 | 0.358 | -3 | 0.858 |
PKN3 |
0.829 | 0.288 | -3 | 0.849 |
ICK |
0.828 | 0.331 | -3 | 0.872 |
CAMK2D |
0.828 | 0.264 | -3 | 0.811 |
DAPK2 |
0.826 | 0.340 | -3 | 0.835 |
NUAK2 |
0.826 | 0.295 | -3 | 0.865 |
CLK4 |
0.826 | 0.342 | -3 | 0.872 |
LATS1 |
0.826 | 0.308 | -3 | 0.854 |
CAMLCK |
0.826 | 0.281 | -2 | 0.818 |
AMPKA1 |
0.825 | 0.281 | -3 | 0.842 |
AKT2 |
0.825 | 0.403 | -3 | 0.849 |
SRPK2 |
0.825 | 0.352 | -3 | 0.853 |
DYRK2 |
0.824 | 0.227 | 1 | 0.662 |
PKACA |
0.824 | 0.350 | -2 | 0.649 |
MAPKAPK3 |
0.824 | 0.312 | -3 | 0.838 |
RAF1 |
0.823 | 0.096 | 1 | 0.801 |
SGK3 |
0.823 | 0.362 | -3 | 0.851 |
TSSK1 |
0.823 | 0.287 | -3 | 0.847 |
PRKD3 |
0.823 | 0.379 | -3 | 0.839 |
AMPKA2 |
0.822 | 0.298 | -3 | 0.850 |
MARK4 |
0.822 | 0.183 | 4 | 0.850 |
PASK |
0.821 | 0.406 | -3 | 0.865 |
MTOR |
0.821 | 0.064 | 1 | 0.743 |
CAMK2G |
0.821 | 0.050 | 2 | 0.797 |
HIPK2 |
0.821 | 0.246 | 1 | 0.579 |
PKN2 |
0.821 | 0.241 | -3 | 0.829 |
MYLK4 |
0.821 | 0.299 | -2 | 0.761 |
PRPK |
0.821 | -0.046 | -1 | 0.775 |
SRPK3 |
0.820 | 0.310 | -3 | 0.858 |
HIPK1 |
0.820 | 0.277 | 1 | 0.682 |
TSSK2 |
0.820 | 0.228 | -5 | 0.780 |
IKKB |
0.819 | 0.016 | -2 | 0.698 |
QSK |
0.819 | 0.277 | 4 | 0.824 |
CLK1 |
0.819 | 0.324 | -3 | 0.853 |
PIM2 |
0.819 | 0.370 | -3 | 0.858 |
NIK |
0.819 | 0.220 | -3 | 0.813 |
ATR |
0.819 | 0.041 | 1 | 0.758 |
PAK1 |
0.818 | 0.200 | -2 | 0.759 |
DYRK4 |
0.818 | 0.219 | 1 | 0.594 |
GRK7 |
0.817 | 0.187 | 1 | 0.751 |
NLK |
0.816 | 0.056 | 1 | 0.780 |
BMPR1B |
0.816 | 0.176 | 1 | 0.818 |
CAMK1G |
0.816 | 0.335 | -3 | 0.840 |
WNK1 |
0.816 | 0.125 | -2 | 0.839 |
GRK6 |
0.816 | 0.095 | 1 | 0.822 |
SGK1 |
0.815 | 0.424 | -3 | 0.826 |
DYRK1A |
0.815 | 0.292 | 1 | 0.680 |
PDHK4 |
0.815 | -0.135 | 1 | 0.803 |
PKG2 |
0.815 | 0.254 | -2 | 0.702 |
AURB |
0.815 | 0.191 | -2 | 0.668 |
RIPK3 |
0.815 | 0.050 | 3 | 0.718 |
TBK1 |
0.814 | -0.042 | 1 | 0.700 |
CAMK4 |
0.814 | 0.214 | -3 | 0.820 |
CAMK1D |
0.814 | 0.381 | -3 | 0.823 |
KIS |
0.814 | 0.088 | 1 | 0.648 |
SIK |
0.814 | 0.298 | -3 | 0.825 |
PKCD |
0.814 | 0.192 | 2 | 0.709 |
HUNK |
0.813 | 0.031 | 2 | 0.770 |
AURA |
0.813 | 0.180 | -2 | 0.633 |
ERK5 |
0.813 | 0.021 | 1 | 0.764 |
MST4 |
0.813 | 0.097 | 2 | 0.802 |
IKKE |
0.812 | -0.048 | 1 | 0.698 |
DCAMKL1 |
0.811 | 0.316 | -3 | 0.854 |
GRK5 |
0.811 | -0.028 | -3 | 0.715 |
BRSK1 |
0.811 | 0.245 | -3 | 0.845 |
MARK3 |
0.811 | 0.199 | 4 | 0.787 |
IKKA |
0.811 | 0.020 | -2 | 0.683 |
DYRK3 |
0.810 | 0.286 | 1 | 0.683 |
DSTYK |
0.810 | -0.049 | 2 | 0.830 |
BMPR2 |
0.810 | -0.180 | -2 | 0.815 |
NUAK1 |
0.809 | 0.247 | -3 | 0.848 |
MELK |
0.809 | 0.252 | -3 | 0.835 |
MAK |
0.809 | 0.342 | -2 | 0.725 |
AKT1 |
0.808 | 0.340 | -3 | 0.851 |
TGFBR1 |
0.808 | 0.089 | -2 | 0.752 |
FAM20C |
0.808 | 0.070 | 2 | 0.611 |
MASTL |
0.808 | -0.024 | -2 | 0.767 |
AKT3 |
0.808 | 0.388 | -3 | 0.835 |
CHAK2 |
0.808 | -0.012 | -1 | 0.796 |
MNK2 |
0.807 | 0.153 | -2 | 0.771 |
DYRK1B |
0.807 | 0.198 | 1 | 0.618 |
PAK3 |
0.807 | 0.130 | -2 | 0.753 |
DAPK1 |
0.807 | 0.340 | -3 | 0.864 |
MNK1 |
0.807 | 0.171 | -2 | 0.782 |
P70S6K |
0.807 | 0.322 | -3 | 0.827 |
NIM1 |
0.807 | 0.128 | 3 | 0.730 |
RIPK1 |
0.807 | 0.048 | 1 | 0.763 |
PDHK1 |
0.806 | -0.166 | 1 | 0.793 |
DAPK3 |
0.806 | 0.325 | -3 | 0.867 |
SBK |
0.806 | 0.421 | -3 | 0.793 |
CHK1 |
0.806 | 0.196 | -3 | 0.813 |
DLK |
0.805 | 0.031 | 1 | 0.791 |
MARK2 |
0.805 | 0.160 | 4 | 0.766 |
JNK2 |
0.805 | 0.083 | 1 | 0.584 |
ALK4 |
0.805 | 0.042 | -2 | 0.776 |
SMMLCK |
0.804 | 0.284 | -3 | 0.844 |
PAK2 |
0.804 | 0.128 | -2 | 0.744 |
QIK |
0.804 | 0.154 | -3 | 0.796 |
TGFBR2 |
0.804 | -0.012 | -2 | 0.738 |
GCN2 |
0.804 | -0.179 | 2 | 0.751 |
PKCB |
0.803 | 0.156 | 2 | 0.650 |
PKCG |
0.803 | 0.130 | 2 | 0.660 |
ATM |
0.803 | 0.003 | 1 | 0.695 |
PKCA |
0.803 | 0.138 | 2 | 0.641 |
HIPK3 |
0.803 | 0.220 | 1 | 0.663 |
ALK2 |
0.802 | 0.085 | -2 | 0.772 |
CAMK1A |
0.802 | 0.374 | -3 | 0.820 |
CDK18 |
0.802 | 0.076 | 1 | 0.576 |
GRK4 |
0.802 | -0.040 | -2 | 0.796 |
MARK1 |
0.801 | 0.161 | 4 | 0.802 |
DRAK1 |
0.801 | 0.145 | 1 | 0.775 |
DCAMKL2 |
0.801 | 0.225 | -3 | 0.846 |
MAPKAPK5 |
0.801 | 0.242 | -3 | 0.815 |
BRSK2 |
0.800 | 0.152 | -3 | 0.817 |
CDK7 |
0.800 | 0.035 | 1 | 0.633 |
BCKDK |
0.799 | -0.111 | -1 | 0.714 |
ULK2 |
0.799 | -0.201 | 2 | 0.717 |
JNK3 |
0.799 | 0.049 | 1 | 0.616 |
PLK1 |
0.799 | -0.019 | -2 | 0.724 |
P38A |
0.799 | 0.056 | 1 | 0.663 |
PAK6 |
0.798 | 0.125 | -2 | 0.682 |
CDK8 |
0.798 | -0.005 | 1 | 0.623 |
DNAPK |
0.798 | 0.050 | 1 | 0.631 |
CDK1 |
0.797 | 0.039 | 1 | 0.606 |
ANKRD3 |
0.797 | -0.087 | 1 | 0.809 |
WNK3 |
0.797 | -0.126 | 1 | 0.752 |
PKR |
0.797 | 0.013 | 1 | 0.786 |
P38B |
0.797 | 0.056 | 1 | 0.603 |
CHK2 |
0.797 | 0.371 | -3 | 0.815 |
PKCZ |
0.797 | 0.094 | 2 | 0.697 |
GRK2 |
0.796 | 0.032 | -2 | 0.691 |
ACVR2B |
0.796 | 0.033 | -2 | 0.727 |
MEK1 |
0.796 | -0.051 | 2 | 0.806 |
BMPR1A |
0.796 | 0.099 | 1 | 0.798 |
MLK1 |
0.796 | -0.157 | 2 | 0.741 |
PLK3 |
0.795 | -0.024 | 2 | 0.762 |
CDK19 |
0.795 | 0.010 | 1 | 0.588 |
CK1E |
0.795 | 0.037 | -3 | 0.470 |
PHKG1 |
0.795 | 0.119 | -3 | 0.842 |
GSK3A |
0.795 | 0.119 | 4 | 0.495 |
TTBK2 |
0.795 | -0.098 | 2 | 0.663 |
DMPK1 |
0.794 | 0.352 | -3 | 0.855 |
PKCH |
0.794 | 0.106 | 2 | 0.630 |
CK2A2 |
0.794 | 0.156 | 1 | 0.753 |
ROCK2 |
0.794 | 0.318 | -3 | 0.857 |
CDK14 |
0.794 | 0.105 | 1 | 0.620 |
MRCKA |
0.794 | 0.300 | -3 | 0.843 |
VRK2 |
0.794 | -0.101 | 1 | 0.816 |
CRIK |
0.794 | 0.382 | -3 | 0.858 |
NEK6 |
0.794 | -0.152 | -2 | 0.784 |
ACVR2A |
0.793 | 0.009 | -2 | 0.710 |
MRCKB |
0.793 | 0.310 | -3 | 0.837 |
SSTK |
0.793 | 0.143 | 4 | 0.812 |
NEK7 |
0.793 | -0.219 | -3 | 0.690 |
PRP4 |
0.792 | 0.083 | -3 | 0.725 |
MLK2 |
0.792 | -0.127 | 2 | 0.750 |
MOK |
0.792 | 0.299 | 1 | 0.697 |
CDK10 |
0.792 | 0.121 | 1 | 0.606 |
P38G |
0.792 | 0.037 | 1 | 0.522 |
CDK17 |
0.791 | 0.036 | 1 | 0.528 |
GAK |
0.790 | 0.192 | 1 | 0.838 |
CK1D |
0.790 | 0.040 | -3 | 0.420 |
IRE1 |
0.790 | -0.064 | 1 | 0.731 |
CDK13 |
0.790 | -0.004 | 1 | 0.608 |
CDK5 |
0.790 | 0.023 | 1 | 0.649 |
NEK9 |
0.790 | -0.200 | 2 | 0.761 |
GSK3B |
0.790 | 0.082 | 4 | 0.488 |
CDK12 |
0.789 | 0.025 | 1 | 0.580 |
YSK4 |
0.789 | -0.092 | 1 | 0.733 |
ERK1 |
0.789 | 0.016 | 1 | 0.591 |
CK1A2 |
0.789 | 0.032 | -3 | 0.429 |
CDK9 |
0.788 | 0.010 | 1 | 0.617 |
GRK3 |
0.788 | 0.037 | -2 | 0.663 |
MPSK1 |
0.788 | 0.121 | 1 | 0.754 |
TLK2 |
0.788 | -0.077 | 1 | 0.710 |
MLK3 |
0.788 | -0.094 | 2 | 0.665 |
SMG1 |
0.787 | -0.076 | 1 | 0.702 |
MST3 |
0.787 | 0.061 | 2 | 0.772 |
ULK1 |
0.787 | -0.236 | -3 | 0.649 |
BRAF |
0.786 | -0.036 | -4 | 0.778 |
CK2A1 |
0.786 | 0.147 | 1 | 0.738 |
PAK5 |
0.785 | 0.122 | -2 | 0.630 |
WNK4 |
0.785 | 0.020 | -2 | 0.827 |
SNRK |
0.785 | 0.010 | 2 | 0.626 |
PAK4 |
0.785 | 0.127 | -2 | 0.634 |
PKCE |
0.785 | 0.182 | 2 | 0.636 |
PKN1 |
0.784 | 0.257 | -3 | 0.827 |
JNK1 |
0.784 | 0.046 | 1 | 0.582 |
PLK4 |
0.784 | -0.053 | 2 | 0.597 |
PDK1 |
0.784 | 0.133 | 1 | 0.754 |
PKCT |
0.783 | 0.132 | 2 | 0.639 |
NEK2 |
0.783 | -0.130 | 2 | 0.734 |
CDK3 |
0.782 | 0.023 | 1 | 0.549 |
ERK2 |
0.782 | -0.025 | 1 | 0.624 |
MEKK3 |
0.782 | -0.082 | 1 | 0.759 |
CDK16 |
0.782 | 0.036 | 1 | 0.543 |
TAO3 |
0.781 | 0.000 | 1 | 0.747 |
P38D |
0.781 | 0.032 | 1 | 0.528 |
MEK5 |
0.781 | -0.137 | 2 | 0.766 |
BUB1 |
0.781 | 0.189 | -5 | 0.793 |
PLK2 |
0.780 | 0.017 | -3 | 0.655 |
MLK4 |
0.780 | -0.131 | 2 | 0.651 |
CK1G1 |
0.780 | -0.018 | -3 | 0.474 |
GCK |
0.780 | 0.090 | 1 | 0.758 |
IRE2 |
0.780 | -0.102 | 2 | 0.654 |
PKCI |
0.779 | 0.091 | 2 | 0.663 |
CHAK1 |
0.779 | -0.156 | 2 | 0.701 |
NEK5 |
0.779 | -0.097 | 1 | 0.765 |
MEKK1 |
0.779 | -0.142 | 1 | 0.753 |
TLK1 |
0.778 | -0.101 | -2 | 0.765 |
ROCK1 |
0.778 | 0.283 | -3 | 0.843 |
CDK2 |
0.778 | -0.052 | 1 | 0.688 |
PKG1 |
0.777 | 0.234 | -2 | 0.633 |
LKB1 |
0.777 | -0.012 | -3 | 0.704 |
MEKK2 |
0.776 | -0.112 | 2 | 0.734 |
ZAK |
0.776 | -0.141 | 1 | 0.744 |
PHKG2 |
0.775 | 0.082 | -3 | 0.815 |
NEK11 |
0.775 | -0.067 | 1 | 0.750 |
HPK1 |
0.775 | 0.081 | 1 | 0.749 |
IRAK4 |
0.774 | -0.079 | 1 | 0.739 |
PERK |
0.773 | -0.192 | -2 | 0.776 |
CAMKK2 |
0.772 | -0.086 | -2 | 0.726 |
PBK |
0.771 | 0.121 | 1 | 0.763 |
PINK1 |
0.770 | -0.202 | 1 | 0.768 |
LRRK2 |
0.769 | -0.027 | 2 | 0.777 |
YANK3 |
0.768 | 0.039 | 2 | 0.426 |
KHS1 |
0.768 | 0.056 | 1 | 0.732 |
MAP3K15 |
0.767 | -0.050 | 1 | 0.721 |
MST2 |
0.767 | -0.091 | 1 | 0.760 |
TAO2 |
0.767 | -0.101 | 2 | 0.767 |
CAMKK1 |
0.767 | -0.180 | -2 | 0.724 |
KHS2 |
0.767 | 0.071 | 1 | 0.746 |
TNIK |
0.766 | -0.023 | 3 | 0.751 |
PDHK3_TYR |
0.766 | 0.276 | 4 | 0.885 |
NEK8 |
0.765 | -0.150 | 2 | 0.736 |
TTBK1 |
0.765 | -0.150 | 2 | 0.590 |
HRI |
0.765 | -0.268 | -2 | 0.766 |
LOK |
0.764 | -0.015 | -2 | 0.744 |
MINK |
0.764 | -0.058 | 1 | 0.743 |
STK33 |
0.764 | -0.071 | 2 | 0.597 |
MEKK6 |
0.764 | -0.062 | 1 | 0.730 |
TAK1 |
0.763 | -0.053 | 1 | 0.758 |
NEK4 |
0.763 | -0.132 | 1 | 0.732 |
NEK1 |
0.762 | -0.090 | 1 | 0.744 |
CDK4 |
0.761 | 0.009 | 1 | 0.570 |
EEF2K |
0.761 | -0.103 | 3 | 0.730 |
SLK |
0.761 | -0.044 | -2 | 0.690 |
HGK |
0.761 | -0.086 | 3 | 0.757 |
ERK7 |
0.761 | -0.042 | 2 | 0.483 |
VRK1 |
0.761 | -0.125 | 2 | 0.767 |
MST1 |
0.761 | -0.095 | 1 | 0.743 |
IRAK1 |
0.760 | -0.223 | -1 | 0.640 |
CDK6 |
0.759 | -0.022 | 1 | 0.596 |
MAP2K4_TYR |
0.758 | 0.193 | -1 | 0.800 |
PDHK4_TYR |
0.757 | 0.154 | 2 | 0.848 |
CK1A |
0.756 | 0.017 | -3 | 0.348 |
MAP2K6_TYR |
0.755 | 0.144 | -1 | 0.807 |
BMPR2_TYR |
0.755 | 0.123 | -1 | 0.809 |
HASPIN |
0.753 | 0.023 | -1 | 0.652 |
YSK1 |
0.753 | -0.088 | 2 | 0.728 |
TESK1_TYR |
0.752 | 0.059 | 3 | 0.819 |
PDHK1_TYR |
0.752 | 0.080 | -1 | 0.813 |
MEK2 |
0.751 | -0.235 | 2 | 0.760 |
TTK |
0.750 | -0.056 | -2 | 0.747 |
PKMYT1_TYR |
0.750 | 0.055 | 3 | 0.798 |
MAP2K7_TYR |
0.750 | -0.017 | 2 | 0.808 |
ALPHAK3 |
0.749 | -0.041 | -1 | 0.698 |
BIKE |
0.749 | 0.065 | 1 | 0.747 |
RIPK2 |
0.748 | -0.194 | 1 | 0.698 |
LIMK2_TYR |
0.748 | 0.086 | -3 | 0.779 |
OSR1 |
0.747 | -0.105 | 2 | 0.750 |
EPHA6 |
0.745 | 0.059 | -1 | 0.768 |
PINK1_TYR |
0.743 | -0.068 | 1 | 0.791 |
ASK1 |
0.743 | -0.134 | 1 | 0.715 |
NEK3 |
0.742 | -0.157 | 1 | 0.696 |
MYO3B |
0.741 | -0.079 | 2 | 0.744 |
EPHB4 |
0.740 | 0.007 | -1 | 0.722 |
DDR1 |
0.740 | -0.032 | 4 | 0.819 |
EPHA4 |
0.739 | 0.025 | 2 | 0.771 |
AAK1 |
0.738 | 0.109 | 1 | 0.657 |
RET |
0.737 | -0.094 | 1 | 0.747 |
TXK |
0.737 | 0.070 | 1 | 0.830 |
MST1R |
0.735 | -0.095 | 3 | 0.758 |
TNK2 |
0.735 | 0.017 | 3 | 0.726 |
FGR |
0.734 | -0.013 | 1 | 0.818 |
LIMK1_TYR |
0.733 | -0.139 | 2 | 0.779 |
TAO1 |
0.733 | -0.123 | 1 | 0.669 |
MYO3A |
0.732 | -0.142 | 1 | 0.725 |
INSRR |
0.731 | -0.060 | 3 | 0.711 |
FER |
0.731 | -0.098 | 1 | 0.828 |
SRMS |
0.731 | -0.033 | 1 | 0.821 |
YES1 |
0.731 | -0.055 | -1 | 0.729 |
ABL2 |
0.730 | -0.063 | -1 | 0.689 |
DDR2 |
0.730 | 0.074 | 3 | 0.717 |
YANK2 |
0.730 | -0.023 | 2 | 0.436 |
PTK2 |
0.730 | 0.108 | -1 | 0.738 |
CSF1R |
0.729 | -0.123 | 3 | 0.737 |
ROS1 |
0.729 | -0.129 | 3 | 0.702 |
EPHB3 |
0.729 | -0.040 | -1 | 0.698 |
FGFR2 |
0.729 | -0.089 | 3 | 0.773 |
TYK2 |
0.729 | -0.219 | 1 | 0.742 |
EPHB1 |
0.728 | -0.066 | 1 | 0.807 |
JAK2 |
0.728 | -0.180 | 1 | 0.738 |
CK1G3 |
0.728 | -0.034 | -3 | 0.314 |
JAK3 |
0.727 | -0.108 | 1 | 0.732 |
TYRO3 |
0.727 | -0.170 | 3 | 0.724 |
EPHB2 |
0.727 | -0.039 | -1 | 0.693 |
BLK |
0.726 | 0.019 | -1 | 0.726 |
ABL1 |
0.726 | -0.087 | -1 | 0.676 |
FYN |
0.726 | 0.038 | -1 | 0.706 |
KDR |
0.725 | -0.076 | 3 | 0.713 |
STLK3 |
0.724 | -0.211 | 1 | 0.699 |
EPHA7 |
0.724 | -0.025 | 2 | 0.757 |
ITK |
0.724 | -0.054 | -1 | 0.666 |
KIT |
0.723 | -0.127 | 3 | 0.750 |
LCK |
0.723 | -0.027 | -1 | 0.717 |
MET |
0.723 | -0.072 | 3 | 0.746 |
HCK |
0.723 | -0.097 | -1 | 0.708 |
EPHA3 |
0.723 | -0.062 | 2 | 0.735 |
TNK1 |
0.722 | -0.062 | 3 | 0.713 |
CK1G2 |
0.722 | 0.010 | -3 | 0.396 |
AXL |
0.721 | -0.103 | 3 | 0.740 |
FLT1 |
0.721 | -0.060 | -1 | 0.753 |
NEK10_TYR |
0.721 | -0.084 | 1 | 0.628 |
MERTK |
0.721 | -0.091 | 3 | 0.740 |
PTK2B |
0.720 | -0.014 | -1 | 0.626 |
PDGFRB |
0.719 | -0.183 | 3 | 0.745 |
FGFR3 |
0.719 | -0.098 | 3 | 0.748 |
EPHA5 |
0.719 | -0.026 | 2 | 0.751 |
SYK |
0.719 | 0.064 | -1 | 0.711 |
TNNI3K_TYR |
0.718 | -0.077 | 1 | 0.750 |
TEK |
0.718 | -0.148 | 3 | 0.691 |
FGFR1 |
0.718 | -0.165 | 3 | 0.727 |
BMX |
0.718 | -0.055 | -1 | 0.593 |
ERBB2 |
0.716 | -0.125 | 1 | 0.731 |
EPHA8 |
0.716 | -0.038 | -1 | 0.699 |
NTRK1 |
0.716 | -0.180 | -1 | 0.706 |
JAK1 |
0.715 | -0.123 | 1 | 0.692 |
LTK |
0.715 | -0.135 | 3 | 0.708 |
FLT3 |
0.714 | -0.196 | 3 | 0.719 |
ALK |
0.714 | -0.154 | 3 | 0.683 |
EPHA1 |
0.713 | -0.104 | 3 | 0.724 |
SRC |
0.713 | -0.043 | -1 | 0.693 |
EGFR |
0.712 | -0.068 | 1 | 0.650 |
NTRK3 |
0.712 | -0.134 | -1 | 0.663 |
FRK |
0.711 | -0.112 | -1 | 0.717 |
TEC |
0.711 | -0.132 | -1 | 0.589 |
PDGFRA |
0.710 | -0.246 | 3 | 0.735 |
FLT4 |
0.710 | -0.167 | 3 | 0.715 |
LYN |
0.710 | -0.104 | 3 | 0.671 |
EPHA2 |
0.709 | -0.036 | -1 | 0.671 |
INSR |
0.709 | -0.173 | 3 | 0.681 |
WEE1_TYR |
0.709 | -0.148 | -1 | 0.637 |
MATK |
0.709 | -0.122 | -1 | 0.631 |
FGFR4 |
0.708 | -0.090 | -1 | 0.660 |
CSK |
0.708 | -0.127 | 2 | 0.757 |
ERBB4 |
0.706 | -0.026 | 1 | 0.681 |
BTK |
0.706 | -0.254 | -1 | 0.622 |
PTK6 |
0.705 | -0.246 | -1 | 0.592 |
NTRK2 |
0.704 | -0.247 | 3 | 0.718 |
IGF1R |
0.700 | -0.138 | 3 | 0.640 |
ZAP70 |
0.691 | -0.018 | -1 | 0.636 |
FES |
0.685 | -0.142 | -1 | 0.568 |
MUSK |
0.685 | -0.199 | 1 | 0.637 |