Motif 1158 (n=126)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NIX2 | WTIP | S422 | ochoa | Wilms tumor protein 1-interacting protein (WT1-interacting protein) | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A9LS46, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| B1AHC4 | PRR5-ARHGAP8 | S634 | ochoa | PRR5-ARHGAP8 readthrough | None |
| H3BQ06 | None | S369 | ochoa | TBC1 domain family member 24 | May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking. {ECO:0000256|ARBA:ARBA00046245}. |
| O14681 | EI24 | S330 | ochoa | Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) | Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}. |
| O14901 | KLF11 | S503 | ochoa | Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2) | Transcription factor (PubMed:10207080, PubMed:9748269). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:10207080, PubMed:16131492, PubMed:9748269). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8K1S5, ECO:0000269|PubMed:10207080, ECO:0000269|PubMed:16131492}. |
| O15049 | N4BP3 | S536 | ochoa | NEDD4-binding protein 3 (N4BP3) | Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (PubMed:34880843). Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity). {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000269|PubMed:34880843}. |
| O15198 | SMAD9 | S458 | ochoa | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). |
| O43426 | SYNJ1 | S1565 | ochoa | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}. |
| O43674 | NDUFB5 | S182 | ochoa | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit) | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| O75144 | ICOSLG | S293 | psp | ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275) | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080). {ECO:0000250, ECO:0000269|PubMed:11007762, ECO:0000269|PubMed:11023515, ECO:0000269|PubMed:30498080}. |
| O75508 | CLDN11 | S198 | ochoa | Claudin-11 (Oligodendrocyte-specific protein) | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000269|PubMed:30734065}. |
| O95136 | S1PR2 | S343 | ochoa | Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5) | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:P47752, ECO:0000269|PubMed:10617617, ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:29453251}. |
| O96020 | CCNE2 | S396 | psp | G1/S-specific cyclin-E2 | Essential for the control of the cell cycle at the late G1 and early S phase. {ECO:0000269|PubMed:9840927, ECO:0000269|PubMed:9840943, ECO:0000269|PubMed:9858585}. |
| P02545 | LMNA | S657 | psp | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P13807 | GYS1 | S727 | ochoa|psp | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}. |
| P17813 | ENG | T650 | ochoa|psp | Endoglin (CD antigen CD105) | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:21737454, PubMed:22347366, PubMed:23300529, PubMed:8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529). {ECO:0000250|UniProtKB:Q63961, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:21737454, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:7894484, ECO:0000269|PubMed:8370410, ECO:0000305|PubMed:1692830}. |
| P19525 | EIF2AK2 | S542 | ochoa|psp | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P21333 | FLNA | S2640 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P24928 | POLR2A | S1962 | ochoa | DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) | Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}. |
| P27824 | CANX | S583 | ochoa|psp | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| P28562 | DUSP1 | S359 | psp | Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250|UniProtKB:P28563}. |
| P32004 | L1CAM | S1248 | ochoa|psp | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}. |
| P51784 | USP11 | S953 | ochoa | Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799, PubMed:28992046). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046). {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889, ECO:0000269|PubMed:20233726, ECO:0000269|PubMed:24724799, ECO:0000269|PubMed:28992046}. |
| P52799 | EFNB2 | S325 | ochoa | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}. |
| P81877 | SSBP2 | S354 | ochoa | Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2) | None |
| P84022 | SMAD3 | S416 | ochoa|psp | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}. |
| P85298 | ARHGAP8 | S455 | ochoa|psp | Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P98172 | EFNB1 | S338 | ochoa | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
| P98174 | FGD1 | S954 | ochoa | FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269|PubMed:8969170}. |
| Q01130 | SRSF2 | S212 | ochoa | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q03167 | TGFBR3 | T843 | psp | Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) | Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed:12958365, PubMed:19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed:18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed:19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed:22562249). By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed:19416857, PubMed:19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed:19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity). {ECO:0000250|UniProtKB:P26342, ECO:0000269|PubMed:18184661, ECO:0000269|PubMed:19325136, ECO:0000269|PubMed:19416857, ECO:0000269|PubMed:19726563, ECO:0000269|PubMed:22562249, ECO:0000269|PubMed:34910520}.; FUNCTION: (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL. {ECO:0000269|PubMed:33626330}. |
| Q05193 | DNM1 | S857 | psp | Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}. |
| Q07955 | SRSF1 | S238 | psp | Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) | Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}. |
| Q13115 | DUSP4 | S386 | psp | Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7535768}. |
| Q13427 | PPIG | S745 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q14012 | CAMK1 | S363 | ochoa | Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269|PubMed:11114197, ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:14507913, ECO:0000269|PubMed:14754892, ECO:0000269|PubMed:17056143, ECO:0000269|PubMed:17442826, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:20181577}. |
| Q14118 | DAG1 | S888 | ochoa | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] | The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}. |
| Q14CZ0 | HAPSTR1 | S266 | ochoa | HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein) | Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365). {ECO:0000269|PubMed:33660365, ECO:0000269|PubMed:35776542}. |
| Q15025 | TNIP1 | S627 | ochoa | TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}. |
| Q15398 | DLGAP5 | S839 | ochoa | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}. |
| Q15629 | TRAM1 | S365 | ochoa | Translocating chain-associated membrane protein 1 (Protein TRAM1) | Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:12475939, PubMed:1315422, PubMed:32013668, PubMed:8616892, PubMed:9506517). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER (PubMed:9506517). May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport (PubMed:32013668). Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane (PubMed:8616892). Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane (PubMed:12475939). Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:20430023). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:1315422, ECO:0000269|PubMed:20430023, ECO:0000269|PubMed:32013668, ECO:0000269|PubMed:8616892, ECO:0000269|PubMed:9506517, ECO:0000303|PubMed:32013668}.; FUNCTION: (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells. {ECO:0000269|PubMed:19121997}. |
| Q15773 | MLF2 | S238 | ochoa | Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) | None |
| Q15796 | SMAD2 | S458 | ochoa | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}. |
| Q15797 | SMAD1 | S456 | ochoa | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}. |
| Q16559 | TAL2 | S100 | psp | T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19) | None |
| Q16612 | NREP | S59 | psp | Neuronal regeneration-related protein (Neuronal protein 3.1) (Protein p311) | May have roles in neural function. Ectopic expression augments motility of gliomas. Also promotes axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. {ECO:0000250, ECO:0000269|PubMed:11358844, ECO:0000269|PubMed:16229809}. |
| Q16690 | DUSP5 | S376 | psp | Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH3) | Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. {ECO:0000269|PubMed:7961985}. |
| Q32M88 | PGGHG | S729 | ochoa | Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1) | Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. {ECO:0000269|PubMed:26682924}. |
| Q32P44 | EML3 | S889 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q3KQU3 | MAP7D1 | S834 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3SYG4 | BBS9 | S880 | ochoa | Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein) | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}. |
| Q53GA4 | PHLDA2 | S144 | ochoa | Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C) | Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}. |
| Q5BJF6 | ODF2 | S820 | ochoa | Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) | Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}. |
| Q5JR59 | MTUS2 | S1360 | ochoa | Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) | Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269|PubMed:19543227}. |
| Q5MIZ7 | PPP4R3B | S840 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2) | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. |
| Q5SXM8 | DNLZ | S171 | ochoa | DNL-type zinc finger protein (Hsp70-escort protein 1) (HEP1) (mtHsp70-escort protein) | May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation. {ECO:0000269|PubMed:23462535}. |
| Q5TZA2 | CROCC | S2009 | ochoa | Rootletin (Ciliary rootlet coiled-coil protein) | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}. |
| Q5VY43 | PEAR1 | S1029 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q5XXA6 | ANO1 | S978 | ochoa | Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) | Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q8BHY3, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:28963502, ECO:0000269|PubMed:31732694, ECO:0000269|PubMed:32487539, ECO:0000269|PubMed:33026825, ECO:0000269|PubMed:37253099}.; FUNCTION: [Isoform 4]: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. {ECO:0000269|PubMed:25220078}.; FUNCTION: [Isoform 5]: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+). {ECO:0000269|PubMed:26359375}. |
| Q659C4 | LARP1B | S906 | ochoa | La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2) | None |
| Q66GS9 | CEP135 | S1130 | ochoa | Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) | Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27477386}. |
| Q6DN12 | MCTP2 | S869 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6DT37 | CDC42BPG | S1544 | ochoa | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}. |
| Q6EMK4 | VASN | S665 | ochoa | Vasorin (Protein slit-like 2) | May act as an inhibitor of TGF-beta signaling. {ECO:0000269|PubMed:15247411}. |
| Q6P4R8 | NFRKB | S1291 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6P6C2 | ALKBH5 | S384 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q6P9B9 | INTS5 | S1010 | ochoa | Integrator complex subunit 5 (Int5) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q86T13 | CLEC14A | S483 | ochoa | C-type lectin domain family 14 member A (Epidermal growth factor receptor 5) (EGFR-5) | None |
| Q86V87 | FHIP2B | S736 | ochoa | FHF complex subunit HOOK-interacting protein 2B (FHIP2B) (Retinoic acid-induced protein 16) | Able to activate MAPK/ERK and TGFB signaling pathways (PubMed:22971576). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (By similarity). May play a role in cell proliferation (PubMed:22971576). {ECO:0000250|UniProtKB:Q80YR2, ECO:0000269|PubMed:22971576}. |
| Q86YV9 | HPS6 | T766 | ochoa | BLOC-2 complex member HPS6 (Hermansky-Pudlak syndrome 6 protein) (Ruby-eye protein homolog) (Ru) | May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (PubMed:17041891). Acts as a cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619). {ECO:0000269|PubMed:17041891, ECO:0000269|PubMed:25189619}. |
| Q8IV50 | LYSMD2 | S206 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 2 | None |
| Q8IXL7 | MSRB3 | S183 | ochoa | Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14) | Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. {ECO:0000269|PubMed:14699060, ECO:0000269|PubMed:21185009}. |
| Q8NC74 | RBBP8NL | S655 | ochoa | RBBP8 N-terminal-like protein | None |
| Q8NE01 | CNNM3 | S700 | ochoa | Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3) | Probable metal transporter. {ECO:0000250}. |
| Q8NE79 | POPDC1 | S350 | ochoa | Popeye domain-containing protein 1 (Popeye protein 1) | Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. {ECO:0000250|UniProtKB:Q5PQZ7, ECO:0000250|UniProtKB:Q9ES83, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:26642364}. |
| Q8NFG4 | FLCN | S571 | ochoa|psp | Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) | Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:34381247, PubMed:36103527, PubMed:37079666). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:21209915, PubMed:24081491, PubMed:24095279, PubMed:24448649, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:36103527, PubMed:37079666). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (PubMed:24095279, PubMed:31672913, PubMed:31704029, PubMed:32612235, PubMed:37079666). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (PubMed:31672913, PubMed:32612235). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (PubMed:21209915, PubMed:24081491, PubMed:31672913, PubMed:32612235). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (PubMed:31672913). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (PubMed:31672913). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (PubMed:31272105). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (PubMed:30733432). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (PubMed:27072130). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (PubMed:27113757). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (PubMed:34381247). {ECO:0000250|UniProtKB:Q8QZS3, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:21209915, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:24095279, ECO:0000269|PubMed:24448649, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27072130, ECO:0000269|PubMed:27113757, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31272105, ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32612235, ECO:0000269|PubMed:34381247, ECO:0000269|PubMed:36103527, ECO:0000269|PubMed:37079666}. |
| Q8NFT2 | STEAP2 | S483 | ochoa | Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). {ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8BWB6}. |
| Q8TC07 | TBC1D15 | S682 | ochoa | TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) | Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}. |
| Q8TCA0 | LRRC20 | S175 | ochoa | Leucine-rich repeat-containing protein 20 | None |
| Q8TCT7 | SPPL2B | S583 | ochoa | Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1) | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829951, PubMed:16829952). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). {ECO:0000269|PubMed:16829951, ECO:0000269|PubMed:16829952, ECO:0000269|PubMed:17965014, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:22194595, ECO:0000269|PubMed:23132852}. |
| Q8WUA4 | GTF3C2 | S901 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q8WVB3 | HEXD | S477 | ochoa | Hexosaminidase D (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase D) (Hexosaminidase domain-containing protein) (N-acetyl-beta-galactosaminidase) | Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221). {ECO:0000269|PubMed:19040401, ECO:0000269|PubMed:23099419, ECO:0000269|PubMed:27149221}. |
| Q8WWN9 | IPCEF1 | S427 | ochoa | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}. |
| Q8WWN9 | IPCEF1 | S430 | ochoa | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}. |
| Q8WYL5 | SSH1 | S1042 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q8WYN3 | CSRNP3 | S577 | ochoa | Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2) | Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity). {ECO:0000250}. |
| Q92817 | EVPL | S2025 | ochoa | Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210) | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
| Q92823 | NRCAM | S1295 | ochoa | Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) | Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}. |
| Q93008 | USP9X | S2547 | psp | Ubiquitin carboxyl-terminal hydrolase 9X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X) | Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:18254724, PubMed:19135894, PubMed:22371489, PubMed:25944111, PubMed:29626158, PubMed:30914461, PubMed:37454738). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:18254724, PubMed:19135894, PubMed:22371489, PubMed:25944111, PubMed:29626158, PubMed:30914461, PubMed:37454738). Specifically hydrolyzes 'Lys-11'-, followed by 'Lys-63'-, 'Lys-48'- and 'Lys-6'-linked polyubiquitins chains (PubMed:30914461). Essential component of TGF-beta/BMP signaling cascade (PubMed:19135894). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (PubMed:19135894). Deubiquitinates alkylation repair enzyme ALKBH3 (PubMed:25944111). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Deubiquitinates RNA demethylase enzyme ALKBH5, promoting its stability (PubMed:37454738). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (PubMed:16322459). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:22371489). Deubiquitinates PEG10 (By similarity). Inhibits the activation of the Hippo signaling pathway via deubiquitination of AMOTL2 at 'Lys-347' and 'Lys-408' which prohibits its interaction with and activation of LATS2. Loss of LATS2 activation and subsequent loss of YAP1 phosphorylation results in an increase in YAP1-driven transcription of target genes (PubMed:26598551, PubMed:34404733). {ECO:0000250|UniProtKB:P70398, ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:22371489, ECO:0000269|PubMed:24607389, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:29626158, ECO:0000269|PubMed:30914461, ECO:0000269|PubMed:33378666, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:37454738}. |
| Q96CN5 | LRRC45 | S661 | ochoa|psp | Leucine-rich repeat-containing protein 45 | Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion. {ECO:0000269|PubMed:24035387}. |
| Q96K21 | ZFYVE19 | S463 | ochoa | Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) | Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}. |
| Q9BQE6 | LBHD1 | S282 | ochoa | LBH domain-containing protein 1 | None |
| Q9BRL6 | SRSF8 | S273 | ochoa | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}. |
| Q9BUV0 | RSRP1 | S282 | ochoa | Arginine/serine-rich protein 1 | Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6. {ECO:0000269|PubMed:34042961}. |
| Q9BV73 | CEP250 | S2433 | ochoa | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}. |
| Q9BWW4 | SSBP3 | S381 | ochoa | Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) | May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. {ECO:0000250}. |
| Q9BXS9 | SLC26A6 | S752 | ochoa | Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1) | Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Also mediates intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger also provides a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Also mediates the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. {ECO:0000250|UniProtKB:Q8CIW6, ECO:0000269|PubMed:20501439, ECO:0000269|PubMed:27681177}.; FUNCTION: [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. {ECO:0000269|PubMed:15990874}. |
| Q9BZH6 | WDR11 | S1216 | ochoa | WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) | Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). {ECO:0000269|PubMed:29263200, ECO:0000269|PubMed:29426865}. |
| Q9GZU3 | TMEM39B | S482 | ochoa | Transmembrane protein 39B | May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. {ECO:0000250|UniProtKB:Q7ZW11}. |
| Q9H6Y7 | RNF167 | S341 | ochoa | E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) | E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:33594058, PubMed:35114100). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058). Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562). Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289). Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617). Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890). Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481). Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844). Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289). {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:23129617, ECO:0000269|PubMed:23353890, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:32409562, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:33650289, ECO:0000269|PubMed:35114100}. |
| Q9H871 | RMND5A | S382 | ochoa | E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A) | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). {ECO:0000269|PubMed:29911972}. |
| Q9H8M2 | BRD9 | S588 | ochoa | Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) | Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}. |
| Q9H9Z2 | LIN28A | S200 | ochoa|psp | Protein lin-28 homolog A (Lin-28A) (Zinc finger CCHC domain-containing protein 1) | RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferases (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). This results in the terminal uridylation of target pre-miRNAs (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity). {ECO:0000250|UniProtKB:Q8K3Y3, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:22118463, ECO:0000269|PubMed:22898984, ECO:0000305}. |
| Q9HBG7 | LY9 | S648 | ochoa | T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229) | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). {ECO:0000250|UniProtKB:Q01965, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}. |
| Q9HCU9 | BRMS1 | S237 | ochoa|psp | Breast cancer metastasis-suppressor 1 | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}. |
| Q9NPY3 | CD93 | S645 | ochoa | Complement component C1q receptor (C1q/MBL/SPA receptor) (C1qR) (C1qR(p)) (C1qRp) (CDw93) (Complement component 1 q subcomponent receptor 1) (Matrix-remodeling-associated protein 4) (CD antigen CD93) | Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:7977768). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (PubMed:24809468). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration (PubMed:26848865). Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands (PubMed:28671670, PubMed:36265539, PubMed:38218180). Both ligands play a non-redundant role in CD93-mediated endothelial cell function (PubMed:38218180). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (By similarity). {ECO:0000250|UniProtKB:O89103, ECO:0000269|PubMed:24809468, ECO:0000269|PubMed:26848865, ECO:0000269|PubMed:28671670, ECO:0000269|PubMed:36265539, ECO:0000269|PubMed:38218180, ECO:0000269|PubMed:7977768}. |
| Q9NRD1 | FBXO6 | S284 | ochoa | F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2) | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. {ECO:0000269|PubMed:18203720, ECO:0000269|PubMed:19716789}. |
| Q9NV56 | MRGBP | S195 | ochoa | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Q9NVA1 | UQCC1 | S291 | ochoa | Ubiquinol-cytochrome c reductase complex assembly factor 1 (Basic FGF-repressed Zic-binding protein) (bFGF-repressed Zic-binding protein) (bFZb) (Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog) | Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability. {ECO:0000269|PubMed:24385928}. |
| Q9UHA2 | SS18L2 | S68 | ochoa | SS18-like protein 2 (SYT homolog 2) | None |
| Q9UJX2 | CDC23 | S588 | ochoa | Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9ULW0 | TPX2 | S738 | ochoa|psp | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UPM9 | B9D1 | S197 | ochoa | B9 domain-containing protein 1 (MKS1-related protein 1) | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}. |
| Q9UPN3 | MACF1 | S7380 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y2V7 | COG6 | S648 | ochoa | Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) | Required for normal Golgi function. {ECO:0000250}. |
| Q9Y2Y9 | KLF13 | S279 | ochoa | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage (By similarity). Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1 (PubMed:11477107). Activates RANTES and CCL5 expression in T-cells (PubMed:17513757). {ECO:0000250|UniProtKB:Q9JJZ6, ECO:0000269|PubMed:11477107, ECO:0000269|PubMed:17513757}. |
| Q9Y4U1 | MMACHC | S275 | ochoa | Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) | Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}. |
| Q9Y5U2 | TSSC4 | S321 | ochoa | U5 small nuclear ribonucleoprotein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) | Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}. |
| Q9Y5X2 | SNX8 | S456 | ochoa | Sorting nexin-8 | May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. {ECO:0000269|PubMed:19782049}. |
| Q9Y6G9 | DYNC1LI1 | S516 | ochoa | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}. |
| Q01814 | ATP2B2 | S1234 | Sugiyama | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}. |
| P11836 | MS4A1 | S289 | SIGNOR|ELM|iPTMNet | B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739). {ECO:0000269|PubMed:12920111, ECO:0000269|PubMed:18474602, ECO:0000269|PubMed:3925015, ECO:0000269|PubMed:7684739}. |
| P36888 | FLT3 | S985 | Sugiyama | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) | Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}. |
| Q96FC3 | TPX2 | S204 | GPS6 | TPX2 protein | None |
| Q9GZL7 | WDR12 | S415 | Sugiyama | Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12) | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:17353269}. |
| Q14524 | SCN5A | S2007 | PSP | Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1) | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250|UniProtKB:Q9JJV9, ECO:0000269|PubMed:11234013, ECO:0000269|PubMed:11804990, ECO:0000269|PubMed:12569159, ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:24167619, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430, ECO:0000269|PubMed:26392562, ECO:0000269|PubMed:26776555}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3304347 | Loss of Function of SMAD4 in Cancer | 0.000313 | 3.504 |
| R-HSA-3311021 | SMAD4 MH2 Domain Mutants in Cancer | 0.000313 | 3.504 |
| R-HSA-3315487 | SMAD2/3 MH2 Domain Mutants in Cancer | 0.000313 | 3.504 |
| R-HSA-9839394 | TGFBR3 expression | 0.000153 | 3.816 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.000150 | 3.824 |
| R-HSA-1502540 | Signaling by Activin | 0.000599 | 3.223 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.001233 | 2.909 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.001213 | 2.916 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.001669 | 2.778 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.001669 | 2.778 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 0.001814 | 2.741 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.002168 | 2.664 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.002880 | 2.541 |
| R-HSA-201451 | Signaling by BMP | 0.002880 | 2.541 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.002728 | 2.564 |
| R-HSA-9702506 | Drug resistance of FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702509 | FLT3 mutants bind TKIs | 0.008410 | 2.075 |
| R-HSA-9702636 | tandutinib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702590 | gilteritinib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702614 | ponatinib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702596 | lestaurtinib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702569 | KW2449-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9703009 | tamatinib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702581 | crenolanib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702620 | quizartinib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702624 | sorafenib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702577 | semaxanib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702632 | sunitinib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702998 | linifanib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702605 | pexidartinib-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-9702600 | midostaurin-resistant FLT3 mutants | 0.008410 | 2.075 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.003758 | 2.425 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.004265 | 2.370 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.004914 | 2.309 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 0.007332 | 2.135 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.007998 | 2.097 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.008552 | 2.068 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.009315 | 2.031 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.009526 | 2.021 |
| R-HSA-5688426 | Deubiquitination | 0.009170 | 2.038 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.010254 | 1.989 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.011104 | 1.955 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.011662 | 1.933 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.013711 | 1.863 |
| R-HSA-3928664 | Ephrin signaling | 0.016500 | 1.783 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.017400 | 1.759 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.017868 | 1.748 |
| R-HSA-169131 | Inhibition of PKR | 0.016750 | 1.776 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.016500 | 1.783 |
| R-HSA-9823730 | Formation of definitive endoderm | 0.019283 | 1.715 |
| R-HSA-1181150 | Signaling by NODAL | 0.019283 | 1.715 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 0.025021 | 1.602 |
| R-HSA-5083628 | Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 | 0.025021 | 1.602 |
| R-HSA-3359473 | Defective MMADHC causes MMAHCD | 0.025021 | 1.602 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.022774 | 1.643 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.022774 | 1.643 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.023796 | 1.623 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 0.025021 | 1.602 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.022247 | 1.653 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.022247 | 1.653 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.024082 | 1.618 |
| R-HSA-373760 | L1CAM interactions | 0.025023 | 1.602 |
| R-HSA-9839406 | TGFBR3 regulates activin signaling | 0.033222 | 1.479 |
| R-HSA-5083633 | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 | 0.033222 | 1.479 |
| R-HSA-5083629 | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 | 0.033222 | 1.479 |
| R-HSA-3828062 | Glycogen storage disease type 0 (muscle GYS1) | 0.033222 | 1.479 |
| R-HSA-3814836 | Glycogen storage disease type XV (GYG1) | 0.033222 | 1.479 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.031843 | 1.497 |
| R-HSA-380287 | Centrosome maturation | 0.033852 | 1.470 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.035273 | 1.453 |
| R-HSA-5617833 | Cilium Assembly | 0.032931 | 1.482 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.027729 | 1.557 |
| R-HSA-69275 | G2/M Transition | 0.030690 | 1.513 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.031798 | 1.498 |
| R-HSA-418360 | Platelet calcium homeostasis | 0.035794 | 1.446 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.037664 | 1.424 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.037664 | 1.424 |
| R-HSA-3359474 | Defective MMACHC causes MAHCC | 0.041355 | 1.383 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.041513 | 1.382 |
| R-HSA-72172 | mRNA Splicing | 0.042233 | 1.374 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 0.049420 | 1.306 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 0.049420 | 1.306 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 0.049420 | 1.306 |
| R-HSA-1640170 | Cell Cycle | 0.045419 | 1.343 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.048465 | 1.315 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.049698 | 1.304 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.053885 | 1.269 |
| R-HSA-447038 | NrCAM interactions | 0.057418 | 1.241 |
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 0.057418 | 1.241 |
| R-HSA-9645135 | STAT5 Activation | 0.073213 | 1.135 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.081012 | 1.091 |
| R-HSA-8932506 | DAG1 core M1 glycosylations | 0.081012 | 1.091 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 0.088746 | 1.052 |
| R-HSA-8932504 | DAG1 core M2 glycosylations | 0.088746 | 1.052 |
| R-HSA-9927354 | Co-stimulation by ICOS | 0.088746 | 1.052 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 0.088746 | 1.052 |
| R-HSA-8932505 | DAG1 core M3 glycosylations | 0.111562 | 0.952 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.133810 | 0.874 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.133810 | 0.874 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.155506 | 0.808 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.155506 | 0.808 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.155506 | 0.808 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.183596 | 0.736 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.183596 | 0.736 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.190473 | 0.720 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.197292 | 0.705 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.204054 | 0.690 |
| R-HSA-437239 | Recycling pathway of L1 | 0.079371 | 1.100 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.210759 | 0.676 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.217408 | 0.663 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.217408 | 0.663 |
| R-HSA-72187 | mRNA 3'-end processing | 0.091972 | 1.036 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.243454 | 0.614 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.243454 | 0.614 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.249830 | 0.602 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.249830 | 0.602 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.249830 | 0.602 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.249830 | 0.602 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.328019 | 0.484 |
| R-HSA-167169 | HIV Transcription Elongation | 0.328019 | 0.484 |
| R-HSA-72086 | mRNA Capping | 0.256152 | 0.592 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.328019 | 0.484 |
| R-HSA-8931838 | DAG1 glycosylations | 0.274804 | 0.561 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.210759 | 0.676 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.322303 | 0.492 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.072096 | 1.142 |
| R-HSA-190873 | Gap junction degradation | 0.096415 | 1.016 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.056093 | 1.251 |
| R-HSA-9939291 | Matriglycan biosynthesis on DAG1 | 0.197292 | 0.705 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.268639 | 0.571 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.191835 | 0.717 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.241170 | 0.618 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.169669 | 0.770 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.110337 | 0.957 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.075938 | 1.120 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.075938 | 1.120 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.262422 | 0.581 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.328019 | 0.484 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.304864 | 0.516 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.224002 | 0.650 |
| R-HSA-445144 | Signal transduction by L1 | 0.190473 | 0.720 |
| R-HSA-9759218 | Cobalamin (Cbl) metabolism | 0.243454 | 0.614 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.065349 | 1.185 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 0.088746 | 1.052 |
| R-HSA-196025 | Formation of annular gap junctions | 0.088746 | 1.052 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.096415 | 1.016 |
| R-HSA-202670 | ERKs are inactivated | 0.119040 | 0.924 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.133810 | 0.874 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.162617 | 0.789 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.183596 | 0.736 |
| R-HSA-3322077 | Glycogen synthesis | 0.190473 | 0.720 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.089407 | 1.049 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.097167 | 1.012 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.249830 | 0.602 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.150020 | 0.824 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.259860 | 0.585 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.304864 | 0.516 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.304864 | 0.516 |
| R-HSA-3229121 | Glycogen storage diseases | 0.169669 | 0.770 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 0.133810 | 0.874 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 0.141103 | 0.850 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.162617 | 0.789 |
| R-HSA-420029 | Tight junction interactions | 0.230540 | 0.637 |
| R-HSA-9646399 | Aggrephagy | 0.328019 | 0.484 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.228746 | 0.641 |
| R-HSA-68877 | Mitotic Prometaphase | 0.105898 | 0.975 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.110574 | 0.956 |
| R-HSA-9865881 | Complex III assembly | 0.224002 | 0.650 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.127083 | 0.896 |
| R-HSA-8982491 | Glycogen metabolism | 0.328019 | 0.484 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.148335 | 0.829 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.162617 | 0.789 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 0.176662 | 0.753 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.262422 | 0.581 |
| R-HSA-422475 | Axon guidance | 0.203363 | 0.692 |
| R-HSA-9675108 | Nervous system development | 0.248876 | 0.604 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.204054 | 0.690 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.115961 | 0.936 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.328019 | 0.484 |
| R-HSA-5578775 | Ion homeostasis | 0.102442 | 0.990 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.105110 | 0.978 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.292991 | 0.533 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 0.230540 | 0.637 |
| R-HSA-427601 | Inorganic anion exchange by SLC26 transporters | 0.111562 | 0.952 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 0.148335 | 0.829 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 0.155506 | 0.808 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.286980 | 0.542 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.150020 | 0.824 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 0.292991 | 0.533 |
| R-HSA-68882 | Mitotic Anaphase | 0.140301 | 0.853 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.141823 | 0.848 |
| R-HSA-68886 | M Phase | 0.055753 | 1.254 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.056059 | 1.251 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.322303 | 0.492 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.176705 | 0.753 |
| R-HSA-5576891 | Cardiac conduction | 0.128858 | 0.890 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.161682 | 0.791 |
| R-HSA-9020956 | Interleukin-27 signaling | 0.104020 | 0.983 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.298953 | 0.524 |
| R-HSA-1538133 | G0 and Early G1 | 0.274804 | 0.561 |
| R-HSA-447043 | Neurofascin interactions | 0.073213 | 1.135 |
| R-HSA-5676934 | Protein repair | 0.148335 | 0.829 |
| R-HSA-198753 | ERK/MAPK targets | 0.197292 | 0.705 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.286980 | 0.542 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.328019 | 0.484 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.328019 | 0.484 |
| R-HSA-9683686 | Maturation of spike protein | 0.104020 | 0.983 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 0.230540 | 0.637 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.243454 | 0.614 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.096415 | 1.016 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.197292 | 0.705 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.148335 | 0.829 |
| R-HSA-210991 | Basigin interactions | 0.197292 | 0.705 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.230540 | 0.637 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.230540 | 0.637 |
| R-HSA-397014 | Muscle contraction | 0.312247 | 0.506 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.238061 | 0.623 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.304864 | 0.516 |
| R-HSA-68875 | Mitotic Prophase | 0.312764 | 0.505 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.268639 | 0.571 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.280917 | 0.551 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.297250 | 0.527 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.126456 | 0.898 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 0.126456 | 0.898 |
| R-HSA-9733709 | Cardiogenesis | 0.280917 | 0.551 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.286980 | 0.542 |
| R-HSA-69239 | Synthesis of DNA | 0.266097 | 0.575 |
| R-HSA-1855183 | Synthesis of IP2, IP, and Ins in the cytosol | 0.237024 | 0.625 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.310726 | 0.508 |
| R-HSA-8983711 | OAS antiviral response | 0.126456 | 0.898 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.230540 | 0.637 |
| R-HSA-73942 | DNA Damage Reversal | 0.148335 | 0.829 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.256152 | 0.592 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.262978 | 0.580 |
| R-HSA-983712 | Ion channel transport | 0.257385 | 0.589 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 0.057418 | 1.241 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.155506 | 0.808 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.065055 | 1.187 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.124279 | 0.906 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.303463 | 0.518 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.304864 | 0.516 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.099795 | 1.001 |
| R-HSA-168255 | Influenza Infection | 0.234928 | 0.629 |
| R-HSA-168268 | Virus Assembly and Release | 0.155506 | 0.808 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.316539 | 0.500 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.224002 | 0.650 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.224002 | 0.650 |
| R-HSA-190236 | Signaling by FGFR | 0.234953 | 0.629 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.243454 | 0.614 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.170707 | 0.768 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.199914 | 0.699 |
| R-HSA-391251 | Protein folding | 0.056093 | 1.251 |
| R-HSA-418346 | Platelet homeostasis | 0.262978 | 0.580 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.213286 | 0.671 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.265275 | 0.576 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.274804 | 0.561 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.226048 | 0.646 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.278313 | 0.555 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.191835 | 0.717 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.210206 | 0.677 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.331285 | 0.480 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.331285 | 0.480 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.331285 | 0.480 |
| R-HSA-9607240 | FLT3 Signaling | 0.333687 | 0.477 |
| R-HSA-9694548 | Maturation of spike protein | 0.333687 | 0.477 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.333687 | 0.477 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.339308 | 0.469 |
| R-HSA-167161 | HIV Transcription Initiation | 0.339308 | 0.469 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.339308 | 0.469 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.339308 | 0.469 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.339308 | 0.469 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.340496 | 0.468 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.350408 | 0.455 |
| R-HSA-8854214 | TBC/RABGAPs | 0.350408 | 0.455 |
| R-HSA-9843745 | Adipogenesis | 0.352716 | 0.453 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.355889 | 0.449 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 0.355889 | 0.449 |
| R-HSA-190828 | Gap junction trafficking | 0.355889 | 0.449 |
| R-HSA-69236 | G1 Phase | 0.355889 | 0.449 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.355889 | 0.449 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.361323 | 0.442 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.366712 | 0.436 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.366712 | 0.436 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.366712 | 0.436 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.366712 | 0.436 |
| R-HSA-75153 | Apoptotic execution phase | 0.366712 | 0.436 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.370898 | 0.431 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.372056 | 0.429 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.372056 | 0.429 |
| R-HSA-157118 | Signaling by NOTCH | 0.376601 | 0.424 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.379915 | 0.420 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.382610 | 0.417 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.382610 | 0.417 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.382610 | 0.417 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.382610 | 0.417 |
| R-HSA-109704 | PI3K Cascade | 0.387821 | 0.411 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.387821 | 0.411 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.394822 | 0.404 |
| R-HSA-4839726 | Chromatin organization | 0.397096 | 0.401 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.398112 | 0.400 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.398112 | 0.400 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.398112 | 0.400 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.403193 | 0.394 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.403193 | 0.394 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.403193 | 0.394 |
| R-HSA-1221632 | Meiotic synapsis | 0.403193 | 0.394 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.403193 | 0.394 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.406631 | 0.391 |
| R-HSA-69242 | S Phase | 0.409567 | 0.388 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.409567 | 0.388 |
| R-HSA-166520 | Signaling by NTRKs | 0.409567 | 0.388 |
| R-HSA-9758941 | Gastrulation | 0.412495 | 0.385 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.413228 | 0.384 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.413228 | 0.384 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.413228 | 0.384 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.417414 | 0.379 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.418182 | 0.379 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.418182 | 0.379 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.418182 | 0.379 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.418182 | 0.379 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.418182 | 0.379 |
| R-HSA-75893 | TNF signaling | 0.418182 | 0.379 |
| R-HSA-112399 | IRS-mediated signalling | 0.423095 | 0.374 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.423095 | 0.374 |
| R-HSA-69306 | DNA Replication | 0.424137 | 0.372 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.427029 | 0.370 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.427029 | 0.370 |
| R-HSA-73887 | Death Receptor Signaling | 0.427029 | 0.370 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.427966 | 0.369 |
| R-HSA-9033241 | Peroxisomal protein import | 0.432797 | 0.364 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.442337 | 0.354 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.442337 | 0.354 |
| R-HSA-450294 | MAP kinase activation | 0.442337 | 0.354 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.447047 | 0.350 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.447047 | 0.350 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.447047 | 0.350 |
| R-HSA-6799198 | Complex I biogenesis | 0.451718 | 0.345 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.451718 | 0.345 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.455524 | 0.341 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.456350 | 0.341 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.456350 | 0.341 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.460942 | 0.336 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.460942 | 0.336 |
| R-HSA-446728 | Cell junction organization | 0.461721 | 0.336 |
| R-HSA-167172 | Transcription of the HIV genome | 0.474491 | 0.324 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.474491 | 0.324 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.474491 | 0.324 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.474671 | 0.324 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.483335 | 0.316 |
| R-HSA-448424 | Interleukin-17 signaling | 0.483335 | 0.316 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.487701 | 0.312 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.487701 | 0.312 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.487701 | 0.312 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.487701 | 0.312 |
| R-HSA-3000178 | ECM proteoglycans | 0.487701 | 0.312 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.492031 | 0.308 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.492031 | 0.308 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.492031 | 0.308 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 0.496324 | 0.304 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.496324 | 0.304 |
| R-HSA-611105 | Respiratory electron transport | 0.496713 | 0.304 |
| R-HSA-199991 | Membrane Trafficking | 0.498950 | 0.302 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.500582 | 0.301 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.500582 | 0.301 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.500582 | 0.301 |
| R-HSA-2559583 | Cellular Senescence | 0.502056 | 0.299 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.504803 | 0.297 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.504803 | 0.297 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.504803 | 0.297 |
| R-HSA-8852135 | Protein ubiquitination | 0.504803 | 0.297 |
| R-HSA-5689603 | UCH proteinases | 0.508990 | 0.293 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.513141 | 0.290 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.517257 | 0.286 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.517257 | 0.286 |
| R-HSA-9659379 | Sensory processing of sound | 0.521339 | 0.283 |
| R-HSA-9833482 | PKR-mediated signaling | 0.525386 | 0.280 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.525386 | 0.280 |
| R-HSA-977225 | Amyloid fiber formation | 0.529400 | 0.276 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.530785 | 0.275 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.533379 | 0.273 |
| R-HSA-9679506 | SARS-CoV Infections | 0.538290 | 0.269 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.541239 | 0.267 |
| R-HSA-1500931 | Cell-Cell communication | 0.541575 | 0.266 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.545120 | 0.264 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.545120 | 0.264 |
| R-HSA-1500620 | Meiosis | 0.545120 | 0.264 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.548967 | 0.260 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.548967 | 0.260 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.548967 | 0.260 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.552783 | 0.257 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.553448 | 0.257 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.556566 | 0.254 |
| R-HSA-70268 | Pyruvate metabolism | 0.556566 | 0.254 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.556566 | 0.254 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.558380 | 0.253 |
| R-HSA-9663891 | Selective autophagy | 0.560318 | 0.252 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.560318 | 0.252 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.578609 | 0.238 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.582176 | 0.235 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.585712 | 0.232 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.590292 | 0.229 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.596145 | 0.225 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.599564 | 0.222 |
| R-HSA-157579 | Telomere Maintenance | 0.599564 | 0.222 |
| R-HSA-162582 | Signal Transduction | 0.599624 | 0.222 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.602954 | 0.220 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.602954 | 0.220 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.602954 | 0.220 |
| R-HSA-3214847 | HATs acetylate histones | 0.606316 | 0.217 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.606316 | 0.217 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.616233 | 0.210 |
| R-HSA-1483255 | PI Metabolism | 0.616233 | 0.210 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.623784 | 0.205 |
| R-HSA-73894 | DNA Repair | 0.625047 | 0.204 |
| R-HSA-9833110 | RSV-host interactions | 0.625903 | 0.203 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.629072 | 0.201 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.634154 | 0.198 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.635330 | 0.197 |
| R-HSA-211000 | Gene Silencing by RNA | 0.635330 | 0.197 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.638420 | 0.195 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.638420 | 0.195 |
| R-HSA-8939211 | ESR-mediated signaling | 0.640519 | 0.193 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.641483 | 0.193 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.641483 | 0.193 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.641483 | 0.193 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.644521 | 0.191 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.644521 | 0.191 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.650521 | 0.187 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.653483 | 0.185 |
| R-HSA-2262752 | Cellular responses to stress | 0.656409 | 0.183 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.662220 | 0.179 |
| R-HSA-913531 | Interferon Signaling | 0.666019 | 0.177 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.666019 | 0.177 |
| R-HSA-421270 | Cell-cell junction organization | 0.669084 | 0.175 |
| R-HSA-597592 | Post-translational protein modification | 0.671505 | 0.173 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.673530 | 0.172 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.676298 | 0.170 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.676298 | 0.170 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.676298 | 0.170 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.681765 | 0.166 |
| R-HSA-73886 | Chromosome Maintenance | 0.681765 | 0.166 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.684464 | 0.165 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.684464 | 0.165 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.687141 | 0.163 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.689794 | 0.161 |
| R-HSA-69206 | G1/S Transition | 0.695035 | 0.158 |
| R-HSA-114608 | Platelet degranulation | 0.700188 | 0.155 |
| R-HSA-1266738 | Developmental Biology | 0.702565 | 0.153 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.706234 | 0.151 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.707755 | 0.150 |
| R-HSA-1474165 | Reproduction | 0.710235 | 0.149 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.715133 | 0.146 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.717551 | 0.144 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.725537 | 0.139 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.725843 | 0.139 |
| R-HSA-5173105 | O-linked glycosylation | 0.729339 | 0.137 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.729339 | 0.137 |
| R-HSA-5668914 | Diseases of metabolism | 0.732541 | 0.135 |
| R-HSA-8953854 | Metabolism of RNA | 0.734897 | 0.134 |
| R-HSA-1632852 | Macroautophagy | 0.738416 | 0.132 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.742841 | 0.129 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.751468 | 0.124 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.759809 | 0.119 |
| R-HSA-9824446 | Viral Infection Pathways | 0.760898 | 0.119 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.763874 | 0.117 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.763874 | 0.117 |
| R-HSA-9609507 | Protein localization | 0.765881 | 0.116 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.769844 | 0.114 |
| R-HSA-1989781 | PPARA activates gene expression | 0.769844 | 0.114 |
| R-HSA-9612973 | Autophagy | 0.771801 | 0.112 |
| R-HSA-162587 | HIV Life Cycle | 0.773741 | 0.111 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.773741 | 0.111 |
| R-HSA-9711097 | Cellular response to starvation | 0.775665 | 0.110 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.775801 | 0.110 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.779464 | 0.108 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.781290 | 0.107 |
| R-HSA-109581 | Apoptosis | 0.783199 | 0.106 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.788161 | 0.103 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.799244 | 0.097 |
| R-HSA-74160 | Gene expression (Transcription) | 0.803344 | 0.095 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.804326 | 0.095 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.804326 | 0.095 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.820954 | 0.086 |
| R-HSA-3781865 | Diseases of glycosylation | 0.821891 | 0.085 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.824383 | 0.084 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.827883 | 0.082 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.836676 | 0.077 |
| R-HSA-9609690 | HCMV Early Events | 0.839272 | 0.076 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.839272 | 0.076 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.848622 | 0.071 |
| R-HSA-5357801 | Programmed Cell Death | 0.852462 | 0.069 |
| R-HSA-6805567 | Keratinization | 0.853720 | 0.069 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.861050 | 0.065 |
| R-HSA-418990 | Adherens junctions interactions | 0.868014 | 0.061 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.868470 | 0.061 |
| R-HSA-8951664 | Neddylation | 0.871366 | 0.060 |
| R-HSA-162906 | HIV Infection | 0.877817 | 0.057 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.880921 | 0.055 |
| R-HSA-72312 | rRNA processing | 0.882947 | 0.054 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.887863 | 0.052 |
| R-HSA-392499 | Metabolism of proteins | 0.888534 | 0.051 |
| R-HSA-1280218 | Adaptive Immune System | 0.893165 | 0.049 |
| R-HSA-9609646 | HCMV Infection | 0.899706 | 0.046 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.904745 | 0.043 |
| R-HSA-109582 | Hemostasis | 0.912708 | 0.040 |
| R-HSA-449147 | Signaling by Interleukins | 0.913287 | 0.039 |
| R-HSA-6798695 | Neutrophil degranulation | 0.914317 | 0.039 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.918403 | 0.037 |
| R-HSA-1483257 | Phospholipid metabolism | 0.931897 | 0.031 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.931897 | 0.031 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.946504 | 0.024 |
| R-HSA-1474244 | Extracellular matrix organization | 0.950073 | 0.022 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.954598 | 0.020 |
| R-HSA-212436 | Generic Transcription Pathway | 0.960995 | 0.017 |
| R-HSA-1643685 | Disease | 0.961110 | 0.017 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.962463 | 0.017 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.971301 | 0.013 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.972038 | 0.012 |
| R-HSA-382551 | Transport of small molecules | 0.972680 | 0.012 |
| R-HSA-418594 | G alpha (i) signalling events | 0.974361 | 0.011 |
| R-HSA-72766 | Translation | 0.978819 | 0.009 |
| R-HSA-5663205 | Infectious disease | 0.980795 | 0.008 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.983105 | 0.007 |
| R-HSA-112316 | Neuronal System | 0.984913 | 0.007 |
| R-HSA-388396 | GPCR downstream signalling | 0.991757 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.994763 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 0.995684 | 0.002 |
| R-HSA-168256 | Immune System | 0.996366 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.997275 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.999977 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999984 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.875 | 0.884 | 1 | 0.813 |
P38G |
0.872 | 0.903 | 1 | 0.873 |
CDK8 |
0.871 | 0.886 | 1 | 0.776 |
CDK17 |
0.869 | 0.884 | 1 | 0.863 |
CDK18 |
0.869 | 0.874 | 1 | 0.828 |
CDK1 |
0.867 | 0.859 | 1 | 0.812 |
P38D |
0.867 | 0.891 | 1 | 0.860 |
JNK2 |
0.867 | 0.905 | 1 | 0.829 |
ERK1 |
0.865 | 0.888 | 1 | 0.809 |
CDK3 |
0.864 | 0.774 | 1 | 0.855 |
P38B |
0.863 | 0.900 | 1 | 0.793 |
HIPK2 |
0.861 | 0.793 | 1 | 0.805 |
CDK13 |
0.858 | 0.848 | 1 | 0.802 |
CDK16 |
0.858 | 0.843 | 1 | 0.848 |
JNK3 |
0.858 | 0.892 | 1 | 0.797 |
CDK7 |
0.857 | 0.846 | 1 | 0.780 |
CDK12 |
0.856 | 0.846 | 1 | 0.824 |
CDK5 |
0.856 | 0.832 | 1 | 0.750 |
KIS |
0.855 | 0.747 | 1 | 0.748 |
DYRK4 |
0.851 | 0.788 | 1 | 0.816 |
DYRK2 |
0.851 | 0.778 | 1 | 0.714 |
P38A |
0.848 | 0.868 | 1 | 0.719 |
CDK9 |
0.846 | 0.820 | 1 | 0.794 |
CDK14 |
0.845 | 0.821 | 1 | 0.789 |
CDK10 |
0.845 | 0.779 | 1 | 0.804 |
ERK2 |
0.844 | 0.856 | 1 | 0.759 |
JNK1 |
0.842 | 0.807 | 1 | 0.831 |
CLK3 |
0.841 | 0.537 | 1 | 0.469 |
DYRK1B |
0.839 | 0.742 | 1 | 0.772 |
CDK6 |
0.838 | 0.807 | 1 | 0.805 |
CDK4 |
0.838 | 0.829 | 1 | 0.832 |
HIPK1 |
0.836 | 0.702 | 1 | 0.696 |
HIPK4 |
0.833 | 0.528 | 1 | 0.495 |
NLK |
0.831 | 0.749 | 1 | 0.507 |
DYRK1A |
0.829 | 0.647 | 1 | 0.677 |
MAK |
0.825 | 0.607 | -2 | 0.882 |
HIPK3 |
0.825 | 0.684 | 1 | 0.666 |
ERK5 |
0.825 | 0.454 | 1 | 0.418 |
CDK2 |
0.824 | 0.630 | 1 | 0.684 |
SRPK1 |
0.820 | 0.349 | -3 | 0.709 |
DYRK3 |
0.817 | 0.549 | 1 | 0.655 |
CLK2 |
0.816 | 0.418 | -3 | 0.685 |
ICK |
0.815 | 0.453 | -3 | 0.818 |
MTOR |
0.815 | 0.280 | 1 | 0.299 |
CLK1 |
0.809 | 0.396 | -3 | 0.682 |
CDKL5 |
0.809 | 0.240 | -3 | 0.772 |
CLK4 |
0.806 | 0.359 | -3 | 0.710 |
COT |
0.806 | -0.038 | 2 | 0.889 |
MOK |
0.806 | 0.528 | 1 | 0.578 |
SRPK2 |
0.805 | 0.272 | -3 | 0.631 |
CDKL1 |
0.804 | 0.197 | -3 | 0.777 |
PRP4 |
0.801 | 0.471 | -3 | 0.768 |
SRPK3 |
0.796 | 0.245 | -3 | 0.683 |
CDC7 |
0.796 | -0.076 | 1 | 0.133 |
ERK7 |
0.795 | 0.299 | 2 | 0.579 |
MOS |
0.794 | -0.006 | 1 | 0.167 |
TBK1 |
0.793 | -0.115 | 1 | 0.099 |
ATR |
0.793 | -0.018 | 1 | 0.161 |
PRPK |
0.792 | -0.078 | -1 | 0.850 |
IKKE |
0.790 | -0.138 | 1 | 0.101 |
IKKB |
0.789 | -0.142 | -2 | 0.673 |
PIM3 |
0.788 | -0.031 | -3 | 0.803 |
CHAK2 |
0.787 | -0.013 | -1 | 0.852 |
PDHK4 |
0.787 | -0.135 | 1 | 0.179 |
BMPR2 |
0.785 | -0.158 | -2 | 0.792 |
RAF1 |
0.785 | -0.186 | 1 | 0.116 |
DSTYK |
0.785 | -0.151 | 2 | 0.893 |
GRK1 |
0.783 | -0.009 | -2 | 0.696 |
CAMK1B |
0.783 | -0.065 | -3 | 0.824 |
PRKD1 |
0.783 | -0.018 | -3 | 0.809 |
PKN3 |
0.782 | -0.056 | -3 | 0.797 |
NDR2 |
0.782 | -0.032 | -3 | 0.818 |
GCN2 |
0.782 | -0.211 | 2 | 0.800 |
MLK1 |
0.782 | -0.103 | 2 | 0.829 |
GSK3A |
0.781 | 0.244 | 4 | 0.520 |
WNK1 |
0.781 | -0.085 | -2 | 0.802 |
ULK2 |
0.781 | -0.205 | 2 | 0.791 |
IKKA |
0.781 | -0.070 | -2 | 0.678 |
MPSK1 |
0.781 | 0.150 | 1 | 0.172 |
NEK6 |
0.781 | -0.093 | -2 | 0.756 |
CAMK2G |
0.781 | -0.099 | 2 | 0.797 |
MLK3 |
0.781 | -0.008 | 2 | 0.765 |
SKMLCK |
0.780 | -0.058 | -2 | 0.785 |
NUAK2 |
0.780 | -0.013 | -3 | 0.798 |
NIK |
0.780 | -0.085 | -3 | 0.849 |
PIM1 |
0.779 | 0.004 | -3 | 0.737 |
RSK2 |
0.778 | -0.030 | -3 | 0.734 |
TGFBR2 |
0.778 | -0.103 | -2 | 0.703 |
NEK7 |
0.778 | -0.180 | -3 | 0.865 |
GRK7 |
0.778 | 0.019 | 1 | 0.151 |
RIPK3 |
0.778 | -0.130 | 3 | 0.770 |
BMPR1B |
0.778 | -0.032 | 1 | 0.112 |
MLK2 |
0.777 | -0.069 | 2 | 0.826 |
MST4 |
0.777 | -0.075 | 2 | 0.847 |
PKCD |
0.777 | -0.039 | 2 | 0.801 |
GRK5 |
0.777 | -0.136 | -3 | 0.849 |
CAMLCK |
0.777 | -0.048 | -2 | 0.769 |
PDHK1 |
0.777 | -0.200 | 1 | 0.156 |
PKN2 |
0.776 | -0.086 | -3 | 0.796 |
P90RSK |
0.776 | -0.029 | -3 | 0.737 |
DNAPK |
0.775 | -0.032 | 1 | 0.155 |
DLK |
0.775 | -0.148 | 1 | 0.130 |
PRKD2 |
0.775 | -0.029 | -3 | 0.732 |
IRE1 |
0.775 | -0.074 | 1 | 0.100 |
ULK1 |
0.774 | -0.178 | -3 | 0.833 |
DAPK2 |
0.774 | -0.077 | -3 | 0.842 |
PINK1 |
0.773 | 0.167 | 1 | 0.320 |
HUNK |
0.773 | -0.172 | 2 | 0.825 |
ALK4 |
0.773 | -0.051 | -2 | 0.759 |
MARK4 |
0.772 | -0.083 | 4 | 0.777 |
TGFBR1 |
0.772 | -0.046 | -2 | 0.738 |
NDR1 |
0.772 | -0.090 | -3 | 0.800 |
NEK9 |
0.772 | -0.181 | 2 | 0.836 |
CAMK2D |
0.772 | -0.111 | -3 | 0.820 |
ATM |
0.771 | -0.082 | 1 | 0.130 |
GRK6 |
0.771 | -0.131 | 1 | 0.117 |
IRE2 |
0.771 | -0.055 | 2 | 0.763 |
MAPKAPK3 |
0.771 | -0.086 | -3 | 0.740 |
VRK2 |
0.770 | 0.064 | 1 | 0.208 |
MASTL |
0.770 | -0.178 | -2 | 0.728 |
RSK3 |
0.770 | -0.061 | -3 | 0.724 |
AMPKA1 |
0.770 | -0.099 | -3 | 0.817 |
MAPKAPK2 |
0.770 | -0.050 | -3 | 0.693 |
LATS1 |
0.770 | 0.006 | -3 | 0.844 |
WNK3 |
0.770 | -0.207 | 1 | 0.109 |
MLK4 |
0.769 | -0.065 | 2 | 0.747 |
TSSK2 |
0.768 | -0.091 | -5 | 0.853 |
AURC |
0.767 | -0.028 | -2 | 0.578 |
PKCA |
0.767 | -0.027 | 2 | 0.748 |
PKACG |
0.767 | -0.074 | -2 | 0.653 |
RIPK1 |
0.767 | -0.199 | 1 | 0.097 |
YSK4 |
0.767 | -0.150 | 1 | 0.106 |
TSSK1 |
0.767 | -0.065 | -3 | 0.840 |
PKCB |
0.767 | -0.045 | 2 | 0.757 |
PKR |
0.767 | -0.097 | 1 | 0.123 |
LATS2 |
0.766 | -0.079 | -5 | 0.707 |
PKCG |
0.766 | -0.049 | 2 | 0.764 |
TTBK2 |
0.766 | -0.178 | 2 | 0.719 |
SMG1 |
0.766 | -0.081 | 1 | 0.145 |
AMPKA2 |
0.765 | -0.077 | -3 | 0.780 |
PKCZ |
0.765 | -0.052 | 2 | 0.794 |
P70S6KB |
0.765 | -0.065 | -3 | 0.751 |
CAMK2B |
0.765 | -0.071 | 2 | 0.771 |
CAMK2A |
0.765 | -0.038 | 2 | 0.785 |
BCKDK |
0.765 | -0.188 | -1 | 0.752 |
PAK1 |
0.765 | -0.076 | -2 | 0.727 |
CHAK1 |
0.764 | -0.116 | 2 | 0.786 |
RSK4 |
0.764 | -0.019 | -3 | 0.703 |
FAM20C |
0.764 | -0.006 | 2 | 0.641 |
GRK4 |
0.764 | -0.162 | -2 | 0.722 |
ANKRD3 |
0.764 | -0.211 | 1 | 0.125 |
ACVR2B |
0.763 | -0.098 | -2 | 0.710 |
PAK3 |
0.763 | -0.104 | -2 | 0.719 |
MNK2 |
0.763 | -0.071 | -2 | 0.705 |
MNK1 |
0.763 | -0.049 | -2 | 0.710 |
ALK2 |
0.763 | -0.074 | -2 | 0.738 |
PLK1 |
0.762 | -0.158 | -2 | 0.700 |
GSK3B |
0.762 | 0.081 | 4 | 0.510 |
PHKG1 |
0.762 | -0.091 | -3 | 0.786 |
ACVR2A |
0.762 | -0.100 | -2 | 0.693 |
MEK1 |
0.762 | -0.155 | 2 | 0.842 |
NIM1 |
0.762 | -0.124 | 3 | 0.808 |
GRK2 |
0.761 | -0.076 | -2 | 0.646 |
PRKD3 |
0.761 | -0.050 | -3 | 0.689 |
MSK2 |
0.760 | -0.077 | -3 | 0.713 |
CAMK4 |
0.760 | -0.154 | -3 | 0.777 |
NEK2 |
0.760 | -0.156 | 2 | 0.815 |
BMPR1A |
0.760 | -0.051 | 1 | 0.103 |
NUAK1 |
0.760 | -0.071 | -3 | 0.738 |
PKCH |
0.759 | -0.081 | 2 | 0.743 |
DRAK1 |
0.759 | -0.137 | 1 | 0.103 |
TLK2 |
0.759 | -0.137 | 1 | 0.102 |
QSK |
0.758 | -0.064 | 4 | 0.751 |
CK1E |
0.757 | -0.007 | -3 | 0.547 |
MSK1 |
0.757 | -0.057 | -3 | 0.712 |
MELK |
0.757 | -0.122 | -3 | 0.758 |
PKACB |
0.757 | -0.033 | -2 | 0.591 |
PASK |
0.757 | -0.011 | -3 | 0.841 |
QIK |
0.756 | -0.135 | -3 | 0.805 |
MST3 |
0.756 | -0.068 | 2 | 0.848 |
ZAK |
0.756 | -0.156 | 1 | 0.112 |
PAK6 |
0.756 | -0.060 | -2 | 0.633 |
AKT2 |
0.756 | -0.020 | -3 | 0.632 |
SGK3 |
0.756 | -0.055 | -3 | 0.717 |
PAK2 |
0.756 | -0.106 | -2 | 0.704 |
CHK1 |
0.756 | -0.075 | -3 | 0.807 |
PLK3 |
0.756 | -0.128 | 2 | 0.772 |
PKG2 |
0.756 | -0.056 | -2 | 0.594 |
PIM2 |
0.755 | -0.018 | -3 | 0.696 |
AURB |
0.755 | -0.060 | -2 | 0.573 |
TAO3 |
0.755 | -0.046 | 1 | 0.149 |
MEK5 |
0.754 | -0.158 | 2 | 0.826 |
NEK5 |
0.754 | -0.141 | 1 | 0.102 |
MEKK1 |
0.754 | -0.158 | 1 | 0.119 |
MEKK3 |
0.754 | -0.165 | 1 | 0.122 |
IRAK4 |
0.753 | -0.126 | 1 | 0.082 |
MEKK2 |
0.753 | -0.129 | 2 | 0.808 |
PLK4 |
0.752 | -0.148 | 2 | 0.634 |
SIK |
0.752 | -0.083 | -3 | 0.712 |
PRKX |
0.752 | -0.013 | -3 | 0.618 |
GAK |
0.752 | -0.032 | 1 | 0.166 |
WNK4 |
0.752 | -0.134 | -2 | 0.796 |
MYLK4 |
0.752 | -0.085 | -2 | 0.687 |
DCAMKL1 |
0.751 | -0.089 | -3 | 0.730 |
CK1D |
0.751 | 0.010 | -3 | 0.496 |
MARK3 |
0.751 | -0.077 | 4 | 0.702 |
MAPKAPK5 |
0.750 | -0.123 | -3 | 0.695 |
HRI |
0.750 | -0.188 | -2 | 0.752 |
CAMK1G |
0.750 | -0.091 | -3 | 0.712 |
NEK11 |
0.750 | -0.129 | 1 | 0.143 |
BUB1 |
0.749 | 0.041 | -5 | 0.844 |
AURA |
0.749 | -0.069 | -2 | 0.546 |
PERK |
0.749 | -0.191 | -2 | 0.729 |
GCK |
0.748 | -0.064 | 1 | 0.134 |
BRSK1 |
0.748 | -0.104 | -3 | 0.741 |
BRSK2 |
0.748 | -0.127 | -3 | 0.770 |
MARK2 |
0.748 | -0.095 | 4 | 0.664 |
PKCT |
0.748 | -0.089 | 2 | 0.745 |
BRAF |
0.748 | -0.176 | -4 | 0.829 |
MAP3K15 |
0.748 | -0.071 | 1 | 0.124 |
LKB1 |
0.747 | -0.067 | -3 | 0.845 |
PKCI |
0.747 | -0.061 | 2 | 0.764 |
AKT1 |
0.747 | -0.040 | -3 | 0.652 |
DCAMKL2 |
0.746 | -0.092 | -3 | 0.752 |
PDK1 |
0.746 | -0.083 | 1 | 0.147 |
GRK3 |
0.745 | -0.081 | -2 | 0.601 |
HGK |
0.745 | -0.067 | 3 | 0.926 |
EEF2K |
0.745 | -0.041 | 3 | 0.897 |
TAO2 |
0.744 | -0.081 | 2 | 0.848 |
PKCE |
0.744 | -0.031 | 2 | 0.750 |
CK1G1 |
0.744 | -0.054 | -3 | 0.522 |
SMMLCK |
0.744 | -0.085 | -3 | 0.779 |
CAMKK1 |
0.744 | -0.189 | -2 | 0.684 |
CK1A2 |
0.743 | -0.018 | -3 | 0.491 |
TNIK |
0.743 | -0.054 | 3 | 0.917 |
PHKG2 |
0.743 | -0.120 | -3 | 0.738 |
MEKK6 |
0.743 | -0.112 | 1 | 0.123 |
CK2A2 |
0.742 | -0.068 | 1 | 0.100 |
NEK8 |
0.742 | -0.179 | 2 | 0.823 |
MARK1 |
0.742 | -0.122 | 4 | 0.724 |
KHS1 |
0.742 | -0.039 | 1 | 0.123 |
TLK1 |
0.742 | -0.190 | -2 | 0.742 |
SSTK |
0.742 | -0.094 | 4 | 0.726 |
MST2 |
0.742 | -0.138 | 1 | 0.113 |
HPK1 |
0.741 | -0.085 | 1 | 0.136 |
LRRK2 |
0.741 | -0.030 | 2 | 0.845 |
TTBK1 |
0.741 | -0.166 | 2 | 0.641 |
MINK |
0.741 | -0.123 | 1 | 0.104 |
SNRK |
0.741 | -0.210 | 2 | 0.674 |
CAMKK2 |
0.740 | -0.154 | -2 | 0.685 |
NEK4 |
0.740 | -0.175 | 1 | 0.095 |
PKN1 |
0.739 | -0.067 | -3 | 0.678 |
KHS2 |
0.739 | -0.023 | 1 | 0.138 |
HASPIN |
0.739 | 0.023 | -1 | 0.721 |
PKACA |
0.739 | -0.051 | -2 | 0.543 |
PAK5 |
0.739 | -0.086 | -2 | 0.573 |
PBK |
0.738 | -0.050 | 1 | 0.144 |
PAK4 |
0.737 | -0.070 | -2 | 0.581 |
NEK1 |
0.737 | -0.151 | 1 | 0.087 |
TAK1 |
0.737 | -0.180 | 1 | 0.105 |
P70S6K |
0.737 | -0.086 | -3 | 0.665 |
VRK1 |
0.736 | -0.146 | 2 | 0.844 |
IRAK1 |
0.736 | -0.228 | -1 | 0.764 |
PLK2 |
0.736 | -0.064 | -3 | 0.790 |
CK2A1 |
0.735 | -0.071 | 1 | 0.097 |
SLK |
0.735 | -0.082 | -2 | 0.620 |
BIKE |
0.734 | -0.025 | 1 | 0.157 |
MST1 |
0.734 | -0.141 | 1 | 0.103 |
AAK1 |
0.734 | 0.016 | 1 | 0.167 |
SBK |
0.734 | 0.069 | -3 | 0.511 |
LOK |
0.734 | -0.113 | -2 | 0.672 |
SGK1 |
0.734 | -0.012 | -3 | 0.555 |
DAPK3 |
0.732 | -0.090 | -3 | 0.748 |
AKT3 |
0.732 | -0.032 | -3 | 0.574 |
CAMK1D |
0.732 | -0.087 | -3 | 0.617 |
STK33 |
0.731 | -0.131 | 2 | 0.638 |
YSK1 |
0.731 | -0.123 | 2 | 0.808 |
CHK2 |
0.730 | -0.059 | -3 | 0.571 |
DAPK1 |
0.728 | -0.086 | -3 | 0.732 |
ROCK2 |
0.727 | -0.063 | -3 | 0.737 |
RIPK2 |
0.727 | -0.224 | 1 | 0.094 |
MRCKB |
0.727 | -0.061 | -3 | 0.678 |
MRCKA |
0.726 | -0.070 | -3 | 0.699 |
MEK2 |
0.726 | -0.216 | 2 | 0.804 |
ASK1 |
0.725 | -0.107 | 1 | 0.125 |
OSR1 |
0.725 | -0.087 | 2 | 0.804 |
PDHK3_TYR |
0.723 | 0.167 | 4 | 0.879 |
CAMK1A |
0.722 | -0.071 | -3 | 0.588 |
NEK3 |
0.722 | -0.163 | 1 | 0.115 |
DMPK1 |
0.721 | -0.030 | -3 | 0.696 |
MYO3B |
0.720 | -0.086 | 2 | 0.826 |
ALPHAK3 |
0.718 | -0.074 | -1 | 0.751 |
MYO3A |
0.718 | -0.098 | 1 | 0.117 |
TTK |
0.718 | -0.114 | -2 | 0.716 |
PDHK4_TYR |
0.717 | 0.093 | 2 | 0.871 |
TAO1 |
0.716 | -0.105 | 1 | 0.118 |
CRIK |
0.716 | -0.038 | -3 | 0.664 |
YANK3 |
0.715 | -0.054 | 2 | 0.428 |
TESK1_TYR |
0.713 | 0.022 | 3 | 0.909 |
PKG1 |
0.713 | -0.089 | -2 | 0.505 |
ROCK1 |
0.713 | -0.075 | -3 | 0.694 |
CK1A |
0.713 | -0.025 | -3 | 0.401 |
LIMK2_TYR |
0.713 | 0.102 | -3 | 0.879 |
MAP2K4_TYR |
0.712 | 0.014 | -1 | 0.856 |
PKMYT1_TYR |
0.712 | 0.087 | 3 | 0.870 |
MAP2K6_TYR |
0.711 | 0.027 | -1 | 0.857 |
PDHK1_TYR |
0.710 | 0.005 | -1 | 0.863 |
MAP2K7_TYR |
0.708 | -0.090 | 2 | 0.850 |
BMPR2_TYR |
0.708 | -0.006 | -1 | 0.831 |
PINK1_TYR |
0.706 | -0.121 | 1 | 0.168 |
STLK3 |
0.704 | -0.190 | 1 | 0.098 |
CSF1R |
0.703 | -0.054 | 3 | 0.830 |
JAK2 |
0.701 | -0.105 | 1 | 0.144 |
LIMK1_TYR |
0.701 | -0.021 | 2 | 0.846 |
RET |
0.701 | -0.143 | 1 | 0.135 |
TXK |
0.699 | -0.056 | 1 | 0.103 |
TYK2 |
0.699 | -0.191 | 1 | 0.120 |
NEK10_TYR |
0.698 | -0.101 | 1 | 0.129 |
MST1R |
0.696 | -0.129 | 3 | 0.840 |
JAK1 |
0.696 | -0.074 | 1 | 0.118 |
YES1 |
0.696 | -0.080 | -1 | 0.834 |
ROS1 |
0.695 | -0.129 | 3 | 0.825 |
TYRO3 |
0.694 | -0.160 | 3 | 0.849 |
EPHB4 |
0.694 | -0.122 | -1 | 0.766 |
JAK3 |
0.694 | -0.128 | 1 | 0.131 |
ABL2 |
0.692 | -0.114 | -1 | 0.782 |
EPHA6 |
0.692 | -0.128 | -1 | 0.792 |
KIT |
0.691 | -0.106 | 3 | 0.830 |
TNK2 |
0.691 | -0.097 | 3 | 0.788 |
FGFR2 |
0.691 | -0.063 | 3 | 0.814 |
ITK |
0.690 | -0.114 | -1 | 0.780 |
LCK |
0.690 | -0.086 | -1 | 0.809 |
INSRR |
0.689 | -0.132 | 3 | 0.794 |
DDR1 |
0.689 | -0.158 | 4 | 0.759 |
TNK1 |
0.689 | -0.076 | 3 | 0.818 |
HCK |
0.688 | -0.138 | -1 | 0.805 |
BLK |
0.688 | -0.076 | -1 | 0.804 |
TNNI3K_TYR |
0.688 | -0.059 | 1 | 0.138 |
ABL1 |
0.688 | -0.128 | -1 | 0.782 |
EPHA4 |
0.688 | -0.089 | 2 | 0.778 |
FGR |
0.688 | -0.174 | 1 | 0.101 |
CK1G3 |
0.687 | -0.040 | -3 | 0.348 |
FER |
0.687 | -0.185 | 1 | 0.113 |
SRMS |
0.687 | -0.161 | 1 | 0.093 |
FGFR1 |
0.687 | -0.070 | 3 | 0.793 |
TEK |
0.687 | -0.039 | 3 | 0.783 |
YANK2 |
0.685 | -0.067 | 2 | 0.447 |
PDGFRB |
0.685 | -0.199 | 3 | 0.849 |
KDR |
0.685 | -0.107 | 3 | 0.784 |
EPHB1 |
0.685 | -0.164 | 1 | 0.098 |
FLT3 |
0.685 | -0.172 | 3 | 0.844 |
FYN |
0.684 | -0.069 | -1 | 0.789 |
BMX |
0.683 | -0.103 | -1 | 0.686 |
WEE1_TYR |
0.682 | -0.085 | -1 | 0.736 |
EPHB2 |
0.681 | -0.154 | -1 | 0.743 |
MET |
0.681 | -0.114 | 3 | 0.817 |
PDGFRA |
0.680 | -0.197 | 3 | 0.846 |
DDR2 |
0.680 | -0.043 | 3 | 0.774 |
EPHB3 |
0.680 | -0.174 | -1 | 0.744 |
MERTK |
0.680 | -0.164 | 3 | 0.796 |
FGFR3 |
0.680 | -0.078 | 3 | 0.786 |
BTK |
0.679 | -0.186 | -1 | 0.752 |
TEC |
0.679 | -0.148 | -1 | 0.710 |
FLT1 |
0.679 | -0.132 | -1 | 0.782 |
AXL |
0.678 | -0.189 | 3 | 0.803 |
FRK |
0.677 | -0.138 | -1 | 0.800 |
EGFR |
0.676 | -0.103 | 1 | 0.096 |
ERBB2 |
0.676 | -0.168 | 1 | 0.114 |
ALK |
0.674 | -0.172 | 3 | 0.768 |
EPHA7 |
0.673 | -0.140 | 2 | 0.784 |
SRC |
0.673 | -0.111 | -1 | 0.789 |
LYN |
0.672 | -0.134 | 3 | 0.742 |
FLT4 |
0.672 | -0.166 | 3 | 0.767 |
INSR |
0.672 | -0.166 | 3 | 0.769 |
NTRK1 |
0.672 | -0.224 | -1 | 0.767 |
PTK2B |
0.671 | -0.120 | -1 | 0.756 |
FGFR4 |
0.671 | -0.096 | -1 | 0.728 |
MATK |
0.670 | -0.107 | -1 | 0.713 |
CK1G2 |
0.670 | -0.046 | -3 | 0.441 |
CSK |
0.670 | -0.122 | 2 | 0.779 |
NTRK3 |
0.670 | -0.162 | -1 | 0.717 |
PTK6 |
0.668 | -0.221 | -1 | 0.730 |
LTK |
0.668 | -0.196 | 3 | 0.769 |
NTRK2 |
0.668 | -0.230 | 3 | 0.785 |
PTK2 |
0.668 | -0.065 | -1 | 0.724 |
SYK |
0.667 | -0.087 | -1 | 0.713 |
EPHA1 |
0.667 | -0.190 | 3 | 0.798 |
EPHA3 |
0.666 | -0.170 | 2 | 0.748 |
EPHA8 |
0.666 | -0.127 | -1 | 0.728 |
MUSK |
0.665 | -0.147 | 1 | 0.079 |
EPHA5 |
0.664 | -0.159 | 2 | 0.762 |
ERBB4 |
0.663 | -0.095 | 1 | 0.098 |
EPHA2 |
0.658 | -0.133 | -1 | 0.689 |
IGF1R |
0.656 | -0.154 | 3 | 0.703 |
ZAP70 |
0.655 | -0.066 | -1 | 0.647 |
FES |
0.643 | -0.155 | -1 | 0.674 |