Motif 1155 (n=133)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A075B6T3 | None | S24 | ochoa | Uncharacterized protein | None |
| A0MZ66 | SHTN1 | S628 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A0MZ66 | SHTN1 | S629 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| A1L429 | GAGE12B; | S115 | ochoa | G antigen 12B/C/D/E (GAGE-12B) (GAGE-12C) (GAGE-12D) (GAGE-12E) | None |
| A6NDE8 | GAGE12H | S115 | ochoa | G antigen 12H (GAGE-12H) | None |
| A6NKF1 | SAC3D1 | S402 | ochoa | SAC3 domain-containing protein 1 (SAC3 homology domain-containing protein 1) | Involved in centrosome duplication and mitotic progression. {ECO:0000250}. |
| E9PCH4 | None | S1649 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| I3L0A0 | PEDS1-UBE2V1 | S369 | ochoa | HCG2044781 (PEDS1-UBE2V1 readthrough) | None |
| I3L0E3 | hCG_1984214 | S222 | ochoa | Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) | None |
| I3L0E3 | hCG_1984214 | S223 | ochoa | Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) | None |
| O14715 | RGPD8 | S1763 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14715 | RGPD8 | S1764 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43432 | EIF4G3 | S1582 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O60447 | EVI5 | S807 | ochoa | Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein) | Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis. {ECO:0000269|PubMed:16439210}. |
| O60449 | LY75 | S1719 | ochoa | Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205) | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}. |
| O60671 | RAD1 | S280 | psp | Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein) | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). {ECO:0000269|PubMed:10846170, ECO:0000269|PubMed:10884395, ECO:0000269|PubMed:12578958, ECO:0000269|PubMed:15314187, ECO:0000269|PubMed:15556996, ECO:0000269|PubMed:15871698, ECO:0000269|PubMed:21659603}. |
| O60832 | DKC1 | S513 | ochoa | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:25219674, ECO:0000269|PubMed:32554502}.; FUNCTION: [Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression. {ECO:0000269|PubMed:21820037}. |
| O75376 | NCOR1 | S2438 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75459 | PAGE1 | S144 | ochoa | P antigen family member 1 (PAGE-1) (AL5) (G antigen 9) (GAGE-9) (G antigen family B member 1) (Prostate-associated gene 1 protein) | None |
| O75461 | E2F6 | S280 | ochoa | Transcription factor E2F6 (E2F-6) | Inhibitor of E2F-dependent transcription (PubMed:9501179, PubMed:9689056, PubMed:9704927). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:9501179). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9501179). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9501179, PubMed:9704927). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (PubMed:9501179, PubMed:9689056). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (PubMed:9501179). {ECO:0000250|UniProtKB:O54917, ECO:0000269|PubMed:9501179, ECO:0000269|PubMed:9689056, ECO:0000269|PubMed:9704927}. |
| O75665 | OFD1 | S1011 | ochoa | Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A) | Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164 (By similarity). Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis (PubMed:33934390). Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity). {ECO:0000250|UniProtKB:Q80Z25, ECO:0000269|PubMed:33934390}. |
| O75971 | SNAPC5 | S96 | ochoa | snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. |
| O75971 | SNAPC5 | S98 | ochoa | snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. |
| O75976 | CPD | S1377 | ochoa | Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) | None |
| O75976 | CPD | S1378 | ochoa | Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) | None |
| O76070 | SNCG | S124 | ochoa | Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}. |
| O95232 | LUC7L3 | S431 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| O95625 | ZBTB11 | S1050 | ochoa | Zinc finger and BTB domain-containing protein 11 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P02724 | GYPA | S148 | ochoa | Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. {ECO:0000269|PubMed:10926825, ECO:0000269|PubMed:12813056, ECO:0000269|PubMed:14604989, ECO:0000269|PubMed:19438409, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). {ECO:0000269|PubMed:15331714}.; FUNCTION: (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. {ECO:0000269|PubMed:8009226}. |
| P05114 | HMGN1 | S99 | ochoa|psp | Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}. |
| P06576 | ATP5F1B | S528 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
| P06756 | ITGAV | S1046 | ochoa | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 acts as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). {ECO:0000269|PubMed:10640428, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
| P07910 | HNRNPC | S306 | ochoa | Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2) | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). {ECO:0000269|PubMed:12509468, ECO:0000269|PubMed:16010978, ECO:0000269|PubMed:25719671, ECO:0000269|PubMed:7567451, ECO:0000269|PubMed:8264621}. |
| P13984 | GTF2F2 | S248 | ochoa | General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) | TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. {ECO:0000269|PubMed:2477704}. |
| P14679 | TYR | S527 | psp | Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB) | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582). {ECO:0000250|UniProtKB:P11344, ECO:0000269|PubMed:28661582}. |
| P15529 | CD46 | S391 | ochoa | Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46) | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. {ECO:0000269|PubMed:10843656, ECO:0000269|PubMed:12540904}.; FUNCTION: (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.; FUNCTION: (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. {ECO:0000269|PubMed:12915534, ECO:0000269|PubMed:14566335, ECO:0000269|PubMed:15047806, ECO:0000269|PubMed:15078926, ECO:0000269|PubMed:15919905, ECO:0000269|PubMed:16254377}.; FUNCTION: (Microbial infection) Acts as a receptor for cultured Measles virus. {ECO:0000269|PubMed:10972291, ECO:0000269|PubMed:20010840, ECO:0000269|PubMed:7534417, ECO:0000269|PubMed:8371352, ECO:0000269|PubMed:8402913}.; FUNCTION: (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. {ECO:0000269|PubMed:12663806, ECO:0000269|PubMed:12724329}.; FUNCTION: (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:11260136, PubMed:11971006, PubMed:7708671, PubMed:9379894). |
| P16989 | YBX3 | S370 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17301 | ITGA2 | S1180 | ochoa|psp | Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) | Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}. |
| P24386 | CHM | S651 | ochoa | Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) | Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269|PubMed:18532927, ECO:0000269|PubMed:7957092}. |
| P24386 | CHM | S652 | ochoa | Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) | Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269|PubMed:18532927, ECO:0000269|PubMed:7957092}. |
| P25445 | FAS | S333 | ochoa | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181, ECO:0000269|PubMed:9184224}. |
| P30086 | PEBP1 | S185 | ochoa | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}. |
| P35580 | MYH10 | S1975 | ochoa|psp | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P40925 | MDH1 | S333 | ochoa | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P41208 | CETN2 | S170 | psp | Centrin-2 (Caltractin isoform 1) | Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}. |
| P41227 | NAA10 | S233 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P46736 | BRCC3 | S314 | ochoa | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (PubMed:14636569, PubMed:16707425, PubMed:17525341, PubMed:19202061, PubMed:19261746, PubMed:19261748, PubMed:19261749). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26195665, PubMed:26344097). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity). {ECO:0000250|UniProtKB:P46737, ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26344097}. |
| P51946 | CCNH | S322 | ochoa | Cyclin-H (MO15-associated protein) (p34) (p37) | Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:7533895}. |
| P53985 | SLC16A1 | S498 | ochoa | Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) | Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023). {ECO:0000250|UniProtKB:P53986, ECO:0000250|UniProtKB:P53987, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:32946811, ECO:0000269|PubMed:33333023}. |
| P54578 | USP14 | S492 | ochoa | Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) | Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins (PubMed:35145029). Ensures the regeneration of ubiquitin at the proteasome (PubMed:18162577, PubMed:28396413). Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell (PubMed:18162577). Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:19106094). Also serves as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1 (PubMed:19135427). Indispensable for synaptic development and function at neuromuscular junctions (NMJs) (By similarity). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation (PubMed:27666593). Inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3 (PubMed:35145029). {ECO:0000250|UniProtKB:Q9JMA1, ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:28396413, ECO:0000269|PubMed:35145029}. |
| P55087 | AQP4 | S321 | ochoa | Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) | Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19383790, ECO:0000269|PubMed:37143309, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}. |
| P55087 | AQP4 | S322 | ochoa | Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) | Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19383790, ECO:0000269|PubMed:37143309, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}. |
| P56385 | ATP5ME | S66 | ochoa | ATP synthase F(0) complex subunit e, mitochondrial (ATPase subunit e) (ATP synthase membrane subunit e) [Cleaved into: ATP synthase F(0) complex subunit e, mitochondrial, N-terminally processed] | Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P61457 | PCBD1 | S102 | ochoa | Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD) | Involved in tetrahydrobiopterin biosynthesis (By similarity). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (PubMed:24204001). {ECO:0000250|UniProtKB:P61459, ECO:0000269|PubMed:24204001}. |
| P62699 | YPEL5 | S118 | ochoa | Protein yippee-like 5 | Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Required for normal cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q65Z55, ECO:0000269|PubMed:29911972}. |
| P63313 | TMSB10 | S41 | ochoa | Thymosin beta-10 | Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}. |
| P82094 | TMF1 | S1091 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q00765 | REEP5 | S188 | ochoa | Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2) | Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes. {ECO:0000250|UniProtKB:Q60870}. |
| Q04637 | EIF4G1 | S1596 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
| Q05519 | SRSF11 | S483 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q08495 | DMTN | S403 | psp | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q12798 | CETN1 | S170 | psp | Centrin-1 (Caltractin isoform 2) | Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926). Plays a role in sperm cilia formation (By similarity). {ECO:0000250|UniProtKB:P41209, ECO:0000269|PubMed:8175926}. |
| Q12905 | ILF2 | T388 | ochoa | Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa) | Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:18458058, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:32433969, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12929 | EPS8 | S821 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13066 | GAGE2B | S114 | ochoa | G antigen 2B/2C (GAGE-2B) (GAGE-2C) (Cancer/testis antigen 4.2) (CT4.2) (G antigen 2C) | Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. |
| Q13069 | GAGE5 | S115 | ochoa | G antigen 5 (GAGE-5) (Cancer/testis antigen 4.5) (CT4.5) | None |
| Q13070 | GAGE6 | S115 | ochoa | G antigen 6 (GAGE-6) (Cancer/testis antigen 4.6) (CT4.6) | None |
| Q13404 | UBE2V1 | S146 | ochoa | Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A) | Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:31006531, ECO:0000269|PubMed:9305758, ECO:0000269|PubMed:9418904, ECO:0000269|PubMed:9580084, ECO:0000269|PubMed:9705497}. |
| Q13427 | PPIG | S753 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q14242 | SELPLG | S409 | ochoa | P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162) | A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269|PubMed:11566773, ECO:0000269|PubMed:12403782}.; FUNCTION: (Microbial infection) Acts as a receptor for enterovirus 71. {ECO:0000269|PubMed:19543284}. |
| Q15139 | PRKD1 | S910 | ochoa|psp | Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
| Q16186 | ADRM1 | S405 | ochoa | Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}. |
| Q16352 | INA | S496 | ochoa | Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5) | Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity). {ECO:0000250|UniProtKB:P46660}. |
| Q5UAW9 | GPR157 | S334 | ochoa | G-protein coupled receptor 157 | Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger. {ECO:0000250|UniProtKB:Q8C206}. |
| Q5VZL5 | ZMYM4 | S1547 | ochoa | Zinc finger MYM-type protein 4 (Zinc finger protein 262) | Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
| Q658P3 | STEAP3 | S486 | ochoa | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434). {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434, ECO:0000269|PubMed:26205815}. |
| Q6MZQ0 | PRR5L | S366 | ochoa | Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) | Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062). {ECO:0000269|PubMed:17461779, ECO:0000269|PubMed:21964062, ECO:0000269|PubMed:22609986}. |
| Q6NT46 | GAGE2A | S114 | ochoa | G antigen 2A (GAGE-2A) | None |
| Q6P0N0 | MIS18BP1 | S1129 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P5R6 | RPL22L1 | S120 | ochoa | Ribosomal protein eL22-like (60S ribosomal protein L22-like 1) (Large ribosomal subunit protein eL22-like 1) | None |
| Q6P9G4 | TMEM154 | S181 | ochoa | Transmembrane protein 154 | None |
| Q6UWF3 | SCIMP | S144 | ochoa | SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein) | Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). {ECO:0000250|UniProtKB:Q3UU41, ECO:0000269|PubMed:21930792}. |
| Q7Z2X4 | PID1 | S247 | ochoa | PTB-containing, cubilin and LRP1-interacting protein (P-CLI1) (Phosphotyrosine interaction domain-containing protein 1) (Protein NYGGF4) | Increases proliferation of preadipocytes without affecting adipocytic differentiation. {ECO:0000269|PubMed:16815647}. |
| Q7Z7N9 | TMEM179B | S217 | ochoa | Transmembrane protein 179B | None |
| Q8IVH2 | FOXP4 | S680 | ochoa | Forkhead box protein P4 (Fork head-related protein-like A) | Transcriptional repressor that represses lung-specific expression. {ECO:0000250}. |
| Q8IXU6 | SLC35F2 | S371 | ochoa | Solute carrier family 35 member F2 | Putative solute transporter. {ECO:0000305}. |
| Q8IYB7 | DIS3L2 | S883 | ochoa | DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) | 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}. |
| Q8N163 | CCAR2 | S922 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N4Q1 | CHCHD4 | S141 | ochoa | Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) | Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7 (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665, PubMed:26387864, PubMed:30885959). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS (PubMed:30885959). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864). {ECO:0000269|PubMed:16185709, ECO:0000269|PubMed:19182799, ECO:0000269|PubMed:21059946, ECO:0000269|PubMed:23186364, ECO:0000269|PubMed:23676665, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:26387864, ECO:0000269|PubMed:30885959}. |
| Q8N4Q1 | CHCHD4 | S142 | ochoa | Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) | Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (PubMed:26004228). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7 (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665, PubMed:26387864, PubMed:30885959). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS (PubMed:30885959). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864). {ECO:0000269|PubMed:16185709, ECO:0000269|PubMed:19182799, ECO:0000269|PubMed:21059946, ECO:0000269|PubMed:23186364, ECO:0000269|PubMed:23676665, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:26387864, ECO:0000269|PubMed:30885959}. |
| Q8N531 | FBXL6 | S537 | ochoa | F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A) | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. |
| Q8TAD8 | SNIP1 | S394 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TAD8 | SNIP1 | S396 | ochoa | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:29360106, ECO:0000305|PubMed:33509932}. |
| Q8TBZ6 | TRMT10A | S336 | ochoa | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678). {ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:25053765}. |
| Q8TD55 | PLEKHO2 | S488 | ochoa | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | None |
| Q8TEU7 | RAPGEF6 | S1599 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WYN0 | ATG4A | S397 | psp | Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 2) (Autophagin-2) (Autophagy-related protein 4 homolog A) (HsAPG4A) (hAPG4A) | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:12473658, PubMed:15169837, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004, PubMed:32732290). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine (PubMed:12473658, PubMed:15169837, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:12473658, PubMed:15169837, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004). Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP (PubMed:12473658, PubMed:15169837, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989). Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:12473658, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:21245471, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32732290, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}. |
| Q96DE5 | ANAPC16 | S108 | ochoa | Anaphase-promoting complex subunit 16 (APC16) (Cyclosome subunit 16) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:20360068). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20360068). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:29033132}. |
| Q96FH0 | BORCS8 | S117 | ochoa | BLOC-1-related complex subunit 8 (MEF2B neighbor) | As part of the BLOC-one-related complex (BORC), it plays a role in the movement and localization of lysosomes at the cell periphery (PubMed:25898167, PubMed:38128568). Associated with the cytosolic face of lysosomes, BORC recruits ARL8B to the lysosomal membrane and couples lysosomes to microtubule plus-end-directed kinesin motors, driving lysosome movement toward the cell periphery. {ECO:0000269|PubMed:38128568, ECO:0000305|PubMed:25898167}. |
| Q96FQ6 | S100A16 | S101 | ochoa | Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16) | Calcium-binding protein. Binds one calcium ion per monomer (PubMed:17030513). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity). {ECO:0000250|UniProtKB:Q9D708, ECO:0000269|PubMed:17030513}. |
| Q96RQ3 | MCCC1 | S724 | ochoa | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) | Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195, ECO:0000269|PubMed:32561715}. |
| Q96T23 | RSF1 | S1438 | ochoa | Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) | Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269|PubMed:11788598, ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:28801535}. |
| Q99666 | RGPD5 | S1763 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99666 | RGPD5 | S1764 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BXS4 | TMEM59 | S321 | ochoa | Transmembrane protein 59 (Liver membrane-bound protein) | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:23376921, PubMed:27273576). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}. |
| Q9BZJ0 | CRNKL1 | S846 | ochoa | Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) | Involved in pre-mRNA splicing process (PubMed:11991638, PubMed:12084575, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12084575, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}. |
| Q9BZJ0 | CRNKL1 | S848 | ochoa | Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) | Involved in pre-mRNA splicing process (PubMed:11991638, PubMed:12084575, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12084575, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000305|PubMed:33509932}. |
| Q9BZQ8 | NIBAN1 | S926 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
| Q9GZR7 | DDX24 | S857 | ochoa | ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity). {ECO:0000250|UniProtKB:Q9ESV0, ECO:0000269|PubMed:24204270, ECO:0000269|PubMed:24980433, ECO:0000269|PubMed:25867071, ECO:0000269|PubMed:36298642}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270). {ECO:0000269|PubMed:18289627, ECO:0000269|PubMed:24204270}. |
| Q9H1E3 | NUCKS1 | S240 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H2D6 | TRIOBP | S2362 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9H444 | CHMP4B | S223 | ochoa | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Majority of the protein exists in a folded closed conformation (PubMed:33349255). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:33349255}.; FUNCTION: (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:22422861}. |
| Q9H6Y2 | WDR55 | S382 | ochoa | WD repeat-containing protein 55 | Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}. |
| Q9HC35 | EML4 | S978 | ochoa | Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) | Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Q9NRG0 | CHRAC1 | S131 | ochoa | Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) | Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:14759371). {ECO:0000269|PubMed:14759371}. |
| Q9UER7 | DAXX | S737 | ochoa|psp | Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:15364927, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:17081986, ECO:0000269|PubMed:17942542, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:23222847, ECO:0000269|PubMed:24200965, ECO:0000269|PubMed:24530302}. |
| Q9UEU5 | GAGE2D; | S114 | ochoa | G antigen 2D (GAGE-2D) (Cancer/testis antigen 4.8) (CT4.8) (G antigen 8) (GAGE-8) | None |
| Q9UHE8 | STEAP1 | S337 | ochoa | STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) | Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. {ECO:0000269|PubMed:32409586}. |
| Q9Y2J0 | RPH3A | S692 | ochoa | Rabphilin-3A (Exophilin-1) | Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). {ECO:0000250|UniProtKB:P47709}. |
| Q9Y2J0 | RPH3A | S693 | ochoa | Rabphilin-3A (Exophilin-1) | Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone (By similarity). {ECO:0000250|UniProtKB:P47709}. |
| Q9Y2R5 | MRPS17 | S127 | ochoa | Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt) | None |
| Q9Y2R5 | MRPS17 | S128 | ochoa | Small ribosomal subunit protein uS17m (28S ribosomal protein S17, mitochondrial) (MRP-S17) (S17mt) | None |
| Q9Y2W1 | THRAP3 | T953 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y3B9 | RRP15 | S280 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y4P1 | ATG4B | S392 | ochoa|psp | Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004, PubMed:26378241, PubMed:27527864, PubMed:28633005, PubMed:28821708, PubMed:29232556, PubMed:30076329, PubMed:30443548, PubMed:30661429). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy (PubMed:33773106, PubMed:33909989). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:20818167, PubMed:21177865, PubMed:22302004, PubMed:27527864, PubMed:28287329, PubMed:28633005, PubMed:29458288, PubMed:30661429). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (PubMed:15169837, PubMed:15187094, PubMed:17347651, PubMed:19322194, PubMed:21177865, PubMed:22302004). Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3 (PubMed:31315929, PubMed:33773106). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:15187094, PubMed:19322194, PubMed:28633005, PubMed:29458288, PubMed:32686895, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:15187094, PubMed:19322194, PubMed:29458288, PubMed:32686895, PubMed:33909989). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS) (PubMed:33909989). Compared to other members of the family (ATG4A, ATG4C or ATG4C), constitutes the major protein for proteolytic activation of ATG8 proteins, while it displays weaker delipidation activity than other ATG4 paralogs (PubMed:29458288, PubMed:30661429). Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy (PubMed:33773106). {ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:15187094, ECO:0000269|PubMed:17347651, ECO:0000269|PubMed:19322194, ECO:0000269|PubMed:20818167, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:22302004, ECO:0000269|PubMed:26378241, ECO:0000269|PubMed:27527864, ECO:0000269|PubMed:28287329, ECO:0000269|PubMed:28633005, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29232556, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30076329, ECO:0000269|PubMed:30443548, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:31315929, ECO:0000269|PubMed:32686895, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}. |
| Q9Y592 | CEP83 | S698 | psp | Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) (Renal carcinoma antigen NY-REN-58) | Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23530209}. |
| Q9Y5X5 | NPFFR2 | S519 | psp | Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) | Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:11024015}. |
| Q9Y5X5 | NPFFR2 | S520 | psp | Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) | Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:11024015}. |
| Q9Y618 | NCOR2 | S2511 | psp | Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) | Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045, PubMed:20812024, PubMed:22230954, PubMed:23911289). Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3 (PubMed:22230954). Required to activate the histone deacetylase activity of HDAC3 (PubMed:22230954). Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival (PubMed:18212045, PubMed:23911289). Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:10077563, ECO:0000269|PubMed:10097068, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:22230954, ECO:0000269|PubMed:23911289}.; FUNCTION: [Isoform 1]: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. {ECO:0000269|PubMed:15632172}.; FUNCTION: [Isoform 4]: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. {ECO:0000269|PubMed:15632172}. |
| Q9Y6W5 | WASF2 | S497 | psp | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. {ECO:0000269|PubMed:10381382, ECO:0000269|PubMed:16275905}. |
| Q96C19 | EFHD2 | S237 | Sugiyama | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| P40925 | MDH1 | S332 | Sugiyama | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P28331 | NDUFS1 | S725 | Sugiyama | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) (Complex I-75kD) (CI-75kD) | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:31557978). Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:31557978). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:30879903, PubMed:31557978). {ECO:0000269|PubMed:30879903, ECO:0000269|PubMed:31557978}. |
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| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.001895 | 2.722 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.001592 | 2.798 |
| R-HSA-72172 | mRNA Splicing | 0.002111 | 2.676 |
| R-HSA-1632852 | Macroautophagy | 0.001679 | 2.775 |
| R-HSA-1640170 | Cell Cycle | 0.001913 | 2.718 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.000549 | 3.260 |
| R-HSA-9612973 | Autophagy | 0.002707 | 2.568 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.015651 | 1.805 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.015651 | 1.805 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.015651 | 1.805 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.015651 | 1.805 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.015651 | 1.805 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.038672 | 1.413 |
| R-HSA-9909438 | 3-Methylcrotonyl-CoA carboxylase deficiency | 0.038672 | 1.413 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.007274 | 2.138 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 0.068538 | 1.164 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.090332 | 1.044 |
| R-HSA-9700645 | ALK mutants bind TKIs | 0.090332 | 1.044 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.016961 | 1.771 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 0.022363 | 1.650 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 0.022363 | 1.650 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.029969 | 1.523 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.029969 | 1.523 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.031597 | 1.500 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.146007 | 0.836 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.146007 | 0.836 |
| R-HSA-9646399 | Aggrephagy | 0.053631 | 1.271 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.053631 | 1.271 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.172563 | 0.763 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.172563 | 0.763 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.057710 | 1.239 |
| R-HSA-167161 | HIV Transcription Initiation | 0.057710 | 1.239 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.057710 | 1.239 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.061893 | 1.208 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.185532 | 0.732 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.066177 | 1.179 |
| R-HSA-774815 | Nucleosome assembly | 0.066177 | 1.179 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.066177 | 1.179 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.068355 | 1.165 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.070556 | 1.151 |
| R-HSA-6803529 | FGFR2 alternative splicing | 0.198300 | 0.703 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.198300 | 0.703 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.081899 | 1.087 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.081899 | 1.087 |
| R-HSA-429947 | Deadenylation of mRNA | 0.210869 | 0.676 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.084231 | 1.075 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.084231 | 1.075 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.084231 | 1.075 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.088955 | 1.051 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.091347 | 1.039 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.096185 | 1.017 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.229356 | 0.639 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.229356 | 0.639 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.235423 | 0.628 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.235423 | 0.628 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.241442 | 0.617 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.108588 | 0.964 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.108588 | 0.964 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.116223 | 0.935 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.270840 | 0.567 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.134535 | 0.871 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.276582 | 0.558 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.139882 | 0.854 |
| R-HSA-380287 | Centrosome maturation | 0.139882 | 0.854 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.178436 | 0.749 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.189740 | 0.722 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.244460 | 0.612 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.256098 | 0.592 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.256098 | 0.592 |
| R-HSA-167172 | Transcription of the HIV genome | 0.121388 | 0.916 |
| R-HSA-167169 | HIV Transcription Elongation | 0.053631 | 1.271 |
| R-HSA-72086 | mRNA Capping | 0.031597 | 1.500 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.172825 | 0.762 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.065988 | 1.181 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.044174 | 1.355 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.053631 | 1.271 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.265052 | 0.577 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.170030 | 0.769 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.204002 | 0.690 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.006333 | 2.198 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.051632 | 1.287 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.036862 | 1.433 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.235423 | 0.628 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 0.111620 | 0.952 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.045803 | 1.339 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.229356 | 0.639 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.129238 | 0.889 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.129238 | 0.889 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.053346 | 1.273 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 0.097484 | 1.011 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.038446 | 1.415 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.159389 | 0.798 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.244460 | 0.612 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.009859 | 2.006 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.137203 | 0.863 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.273574 | 0.563 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.133365 | 0.875 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.273574 | 0.563 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.036685 | 1.436 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.053631 | 1.271 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.101096 | 0.995 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.276486 | 0.558 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.083125 | 1.080 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.020953 | 1.679 |
| R-HSA-8949613 | Cristae formation | 0.028375 | 1.547 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.152725 | 0.816 |
| R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 0.172563 | 0.763 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.086583 | 1.063 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 0.241442 | 0.617 |
| R-HSA-162588 | Budding and maturation of HIV virion | 0.253340 | 0.596 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.253340 | 0.596 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.147986 | 0.830 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.166002 | 0.780 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.146007 | 0.836 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.247414 | 0.607 |
| R-HSA-1268020 | Mitochondrial protein import | 0.106074 | 0.974 |
| R-HSA-73886 | Chromosome Maintenance | 0.022651 | 1.645 |
| R-HSA-216083 | Integrin cell surface interactions | 0.147986 | 0.830 |
| R-HSA-162587 | HIV Life Cycle | 0.160916 | 0.793 |
| R-HSA-9843745 | Adipogenesis | 0.111003 | 0.955 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.106074 | 0.974 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.156183 | 0.806 |
| R-HSA-157579 | Telomere Maintenance | 0.209741 | 0.678 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.006426 | 2.192 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.083125 | 1.080 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 0.139237 | 0.856 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.152725 | 0.816 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 0.172563 | 0.763 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 0.185532 | 0.732 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.223242 | 0.651 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.247414 | 0.607 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.259219 | 0.586 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.164466 | 0.784 |
| R-HSA-162906 | HIV Infection | 0.132184 | 0.879 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.247414 | 0.607 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.134535 | 0.871 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.009113 | 2.040 |
| R-HSA-9663891 | Selective autophagy | 0.178436 | 0.749 |
| R-HSA-5662702 | Melanin biosynthesis | 0.179073 | 0.747 |
| R-HSA-389397 | Orexin and neuropeptides FF and QRFP bind to their respective receptors | 0.061159 | 1.214 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.008170 | 2.088 |
| R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | 0.075860 | 1.120 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 0.118606 | 0.926 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 0.118606 | 0.926 |
| R-HSA-432047 | Passive transport by Aquaporins | 0.152725 | 0.816 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.229356 | 0.639 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.137203 | 0.863 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.276582 | 0.558 |
| R-HSA-68877 | Mitotic Prometaphase | 0.234824 | 0.629 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.070556 | 1.151 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.223242 | 0.651 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.078427 | 1.106 |
| R-HSA-196780 | Biotin transport and metabolism | 0.139237 | 0.856 |
| R-HSA-8953854 | Metabolism of RNA | 0.017980 | 1.745 |
| R-HSA-69481 | G2/M Checkpoints | 0.102826 | 0.988 |
| R-HSA-69275 | G2/M Transition | 0.023760 | 1.624 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.059507 | 1.225 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.007274 | 2.138 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.007274 | 2.138 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.007274 | 2.138 |
| R-HSA-447041 | CHL1 interactions | 0.075860 | 1.120 |
| R-HSA-3000170 | Syndecan interactions | 0.022363 | 1.650 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 0.152725 | 0.816 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 0.191941 | 0.717 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.088955 | 1.051 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.223242 | 0.651 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.253340 | 0.596 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.270840 | 0.567 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.276582 | 0.558 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.276582 | 0.558 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.024639 | 1.608 |
| R-HSA-5693538 | Homology Directed Repair | 0.087247 | 1.059 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.198282 | 0.703 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.043394 | 1.363 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.218380 | 0.661 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 0.146007 | 0.836 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.147986 | 0.830 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.066177 | 1.179 |
| R-HSA-3000178 | ECM proteoglycans | 0.129238 | 0.889 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.012214 | 1.913 |
| R-HSA-3323169 | Defects in biotin (Btn) metabolism | 0.090332 | 1.044 |
| R-HSA-8964208 | Phenylalanine metabolism | 0.185532 | 0.732 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.276582 | 0.558 |
| R-HSA-9609690 | HCMV Early Events | 0.241082 | 0.618 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.244460 | 0.612 |
| R-HSA-5617833 | Cilium Assembly | 0.228596 | 0.641 |
| R-HSA-68886 | M Phase | 0.100345 | 0.999 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.005627 | 2.250 |
| R-HSA-9659379 | Sensory processing of sound | 0.032056 | 1.494 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.160916 | 0.793 |
| R-HSA-73894 | DNA Repair | 0.182195 | 0.739 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.151543 | 0.819 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.153403 | 0.814 |
| R-HSA-210990 | PECAM1 interactions | 0.104580 | 0.981 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.132414 | 0.878 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.179073 | 0.747 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.022728 | 1.643 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.018671 | 1.729 |
| R-HSA-3000157 | Laminin interactions | 0.025295 | 1.597 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.164466 | 0.784 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.151543 | 0.819 |
| R-HSA-9609646 | HCMV Infection | 0.165532 | 0.781 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.177786 | 0.750 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.125537 | 0.901 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.014522 | 1.838 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.198300 | 0.703 |
| R-HSA-202424 | Downstream TCR signaling | 0.184075 | 0.735 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.028375 | 1.547 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.244460 | 0.612 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.131880 | 0.880 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.276468 | 0.558 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.036685 | 1.436 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.020565 | 1.687 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.265052 | 0.577 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.270840 | 0.567 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.276582 | 0.558 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.206869 | 0.684 |
| R-HSA-69239 | Synthesis of DNA | 0.241553 | 0.617 |
| R-HSA-69242 | S Phase | 0.144178 | 0.841 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.247368 | 0.607 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.131880 | 0.880 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.004795 | 2.319 |
| R-HSA-210991 | Basigin interactions | 0.185532 | 0.732 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.126608 | 0.898 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.212617 | 0.672 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.212617 | 0.672 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.212617 | 0.672 |
| R-HSA-1989781 | PPARA activates gene expression | 0.157145 | 0.804 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.265052 | 0.577 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.259010 | 0.587 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.033936 | 1.469 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.267748 | 0.572 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.250277 | 0.602 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 0.014503 | 1.839 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.172563 | 0.763 |
| R-HSA-445144 | Signal transduction by L1 | 0.179073 | 0.747 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.223242 | 0.651 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.139882 | 0.854 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.250277 | 0.602 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.235746 | 0.628 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.195429 | 0.709 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.038446 | 1.415 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.217080 | 0.663 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.146320 | 0.835 |
| R-HSA-5218859 | Regulated Necrosis | 0.121388 | 0.916 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.038446 | 1.415 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.270661 | 0.568 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.235423 | 0.628 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.270840 | 0.567 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.139882 | 0.854 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.247368 | 0.607 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.091347 | 1.039 |
| R-HSA-202403 | TCR signaling | 0.250277 | 0.602 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.075028 | 1.125 |
| R-HSA-373760 | L1CAM interactions | 0.084261 | 1.074 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.044722 | 1.349 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.198300 | 0.703 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.096185 | 1.017 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.054553 | 1.263 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.255791 | 0.592 |
| R-HSA-69206 | G1/S Transition | 0.099626 | 1.002 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.101096 | 0.995 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.101096 | 0.995 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.101096 | 0.995 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.101096 | 0.995 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.108588 | 0.964 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.015232 | 1.817 |
| R-HSA-5357801 | Programmed Cell Death | 0.262134 | 0.581 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.186198 | 0.730 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.161696 | 0.791 |
| R-HSA-5205647 | Mitophagy | 0.276582 | 0.558 |
| R-HSA-5620971 | Pyroptosis | 0.235423 | 0.628 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.113424 | 0.945 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.140541 | 0.852 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.150708 | 0.822 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.166623 | 0.778 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.166002 | 0.780 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.249143 | 0.604 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 0.198300 | 0.703 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.155271 | 0.809 |
| R-HSA-422475 | Axon guidance | 0.160836 | 0.794 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.101096 | 0.995 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.142572 | 0.846 |
| R-HSA-9675108 | Nervous system development | 0.199710 | 0.700 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.186904 | 0.728 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.282280 | 0.549 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.282280 | 0.549 |
| R-HSA-169911 | Regulation of Apoptosis | 0.282280 | 0.549 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.282280 | 0.549 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.282280 | 0.549 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 0.282280 | 0.549 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.282280 | 0.549 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.282309 | 0.549 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.282309 | 0.549 |
| R-HSA-68882 | Mitotic Anaphase | 0.285553 | 0.544 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.287692 | 0.541 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.287933 | 0.541 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.287933 | 0.541 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.287933 | 0.541 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.287933 | 0.541 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 0.287933 | 0.541 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.287933 | 0.541 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.291036 | 0.536 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.291036 | 0.536 |
| R-HSA-4641258 | Degradation of DVL | 0.293542 | 0.532 |
| R-HSA-4641257 | Degradation of AXIN | 0.293542 | 0.532 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.293542 | 0.532 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.293542 | 0.532 |
| R-HSA-8963691 | Phenylalanine and tyrosine metabolism | 0.293542 | 0.532 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.293942 | 0.532 |
| R-HSA-1566948 | Elastic fibre formation | 0.299107 | 0.524 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.299107 | 0.524 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.299107 | 0.524 |
| R-HSA-8875878 | MET promotes cell motility | 0.299107 | 0.524 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.302652 | 0.519 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.302652 | 0.519 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.302652 | 0.519 |
| R-HSA-194138 | Signaling by VEGF | 0.302652 | 0.519 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.304628 | 0.516 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.304628 | 0.516 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.304628 | 0.516 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.304628 | 0.516 |
| R-HSA-69541 | Stabilization of p53 | 0.304628 | 0.516 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.304628 | 0.516 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.310107 | 0.508 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.310107 | 0.508 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.310107 | 0.508 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.310107 | 0.508 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.315542 | 0.501 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.315542 | 0.501 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.315542 | 0.501 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.315542 | 0.501 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.315542 | 0.501 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.318161 | 0.497 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.320935 | 0.494 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.320935 | 0.494 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.320935 | 0.494 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.320935 | 0.494 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.320935 | 0.494 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.320935 | 0.494 |
| R-HSA-6798695 | Neutrophil degranulation | 0.325609 | 0.487 |
| R-HSA-9909396 | Circadian clock | 0.325779 | 0.487 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.326286 | 0.486 |
| R-HSA-165159 | MTOR signalling | 0.326286 | 0.486 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.331595 | 0.479 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.331595 | 0.479 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.336863 | 0.473 |
| R-HSA-9907900 | Proteasome assembly | 0.336863 | 0.473 |
| R-HSA-69236 | G1 Phase | 0.336863 | 0.473 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.336863 | 0.473 |
| R-HSA-157118 | Signaling by NOTCH | 0.337109 | 0.472 |
| R-HSA-163685 | Integration of energy metabolism | 0.340137 | 0.468 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.342089 | 0.466 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.342089 | 0.466 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.342089 | 0.466 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.342089 | 0.466 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.342089 | 0.466 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.342089 | 0.466 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.342089 | 0.466 |
| R-HSA-9824272 | Somitogenesis | 0.342089 | 0.466 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.345855 | 0.461 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.345855 | 0.461 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 0.347275 | 0.459 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.347275 | 0.459 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.347275 | 0.459 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.347275 | 0.459 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.347275 | 0.459 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.347275 | 0.459 |
| R-HSA-9675135 | Diseases of DNA repair | 0.347275 | 0.459 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.352420 | 0.453 |
| R-HSA-437239 | Recycling pathway of L1 | 0.352420 | 0.453 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.357524 | 0.447 |
| R-HSA-212436 | Generic Transcription Pathway | 0.358437 | 0.446 |
| R-HSA-9766229 | Degradation of CDH1 | 0.362589 | 0.441 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.362589 | 0.441 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.362589 | 0.441 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.365737 | 0.437 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.367614 | 0.435 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 0.367614 | 0.435 |
| R-HSA-5688426 | Deubiquitination | 0.369309 | 0.433 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.372600 | 0.429 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.372600 | 0.429 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.372600 | 0.429 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.372600 | 0.429 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.376997 | 0.424 |
| R-HSA-72187 | mRNA 3'-end processing | 0.377547 | 0.423 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.377547 | 0.423 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.377547 | 0.423 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.377547 | 0.423 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.377547 | 0.423 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.382455 | 0.417 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.382455 | 0.417 |
| R-HSA-72649 | Translation initiation complex formation | 0.387325 | 0.412 |
| R-HSA-9609507 | Protein localization | 0.390957 | 0.408 |
| R-HSA-69306 | DNA Replication | 0.390957 | 0.408 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.393732 | 0.405 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.396502 | 0.402 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.396951 | 0.401 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.396951 | 0.401 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.397005 | 0.401 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.401707 | 0.396 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.406426 | 0.391 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 0.406426 | 0.391 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.410265 | 0.387 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.411108 | 0.386 |
| R-HSA-180786 | Extension of Telomeres | 0.411108 | 0.386 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.411108 | 0.386 |
| R-HSA-109581 | Apoptosis | 0.415727 | 0.381 |
| R-HSA-351202 | Metabolism of polyamines | 0.415754 | 0.381 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.415754 | 0.381 |
| R-HSA-9824446 | Viral Infection Pathways | 0.419910 | 0.377 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.420363 | 0.376 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.420363 | 0.376 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.420363 | 0.376 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.420363 | 0.376 |
| R-HSA-450294 | MAP kinase activation | 0.420363 | 0.376 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.420363 | 0.376 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.421165 | 0.376 |
| R-HSA-9707616 | Heme signaling | 0.424936 | 0.372 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.424936 | 0.372 |
| R-HSA-6799198 | Complex I biogenesis | 0.429474 | 0.367 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.429474 | 0.367 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.429474 | 0.367 |
| R-HSA-373755 | Semaphorin interactions | 0.429474 | 0.367 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.433975 | 0.363 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.438442 | 0.358 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.438442 | 0.358 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.442655 | 0.354 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.442874 | 0.354 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.447270 | 0.349 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.447270 | 0.349 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.447960 | 0.349 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.453237 | 0.344 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.460256 | 0.337 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.460256 | 0.337 |
| R-HSA-448424 | Interleukin-17 signaling | 0.460256 | 0.337 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.460256 | 0.337 |
| R-HSA-611105 | Respiratory electron transport | 0.461099 | 0.336 |
| R-HSA-168255 | Influenza Infection | 0.463705 | 0.334 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.464516 | 0.333 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.464516 | 0.333 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.468744 | 0.329 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.472938 | 0.325 |
| R-HSA-9749641 | Aspirin ADME | 0.472938 | 0.325 |
| R-HSA-72766 | Translation | 0.475574 | 0.323 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.477099 | 0.321 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.477099 | 0.321 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.477099 | 0.321 |
| R-HSA-917937 | Iron uptake and transport | 0.481228 | 0.318 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.485325 | 0.314 |
| R-HSA-5689603 | UCH proteinases | 0.485325 | 0.314 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.486826 | 0.313 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.493422 | 0.307 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.493422 | 0.307 |
| R-HSA-5619084 | ABC transporter disorders | 0.493422 | 0.307 |
| R-HSA-4086400 | PCP/CE pathway | 0.493422 | 0.307 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.494396 | 0.306 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.501392 | 0.300 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.501392 | 0.300 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.501392 | 0.300 |
| R-HSA-9833482 | PKR-mediated signaling | 0.501392 | 0.300 |
| R-HSA-6806834 | Signaling by MET | 0.501392 | 0.300 |
| R-HSA-74160 | Gene expression (Transcription) | 0.507319 | 0.295 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.509238 | 0.293 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.509238 | 0.293 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.509493 | 0.293 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.513115 | 0.290 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.520778 | 0.283 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.520778 | 0.283 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.523966 | 0.281 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.524565 | 0.280 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.528322 | 0.277 |
| R-HSA-156902 | Peptide chain elongation | 0.535747 | 0.271 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.539416 | 0.268 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.546669 | 0.262 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.553808 | 0.257 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.553808 | 0.257 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.563071 | 0.249 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.564307 | 0.248 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.567753 | 0.246 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.567753 | 0.246 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.570102 | 0.244 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.571171 | 0.243 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.574562 | 0.241 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.577927 | 0.238 |
| R-HSA-190236 | Signaling by FGFR | 0.577927 | 0.238 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.579566 | 0.237 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.584577 | 0.233 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.584577 | 0.233 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.587863 | 0.231 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.588362 | 0.230 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.591123 | 0.228 |
| R-HSA-72312 | rRNA processing | 0.592709 | 0.227 |
| R-HSA-192823 | Viral mRNA Translation | 0.594358 | 0.226 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.594358 | 0.226 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.597023 | 0.224 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.597568 | 0.224 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.597568 | 0.224 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.600752 | 0.221 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.600752 | 0.221 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.607045 | 0.217 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.610155 | 0.215 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.610155 | 0.215 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.610155 | 0.215 |
| R-HSA-199991 | Membrane Trafficking | 0.611048 | 0.214 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.616301 | 0.210 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.616301 | 0.210 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.620380 | 0.207 |
| R-HSA-913531 | Interferon Signaling | 0.620380 | 0.207 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.624233 | 0.205 |
| R-HSA-4839726 | Chromatin organization | 0.628292 | 0.202 |
| R-HSA-168249 | Innate Immune System | 0.628366 | 0.202 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.631250 | 0.200 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.651212 | 0.186 |
| R-HSA-3371556 | Cellular response to heat stress | 0.656716 | 0.183 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.656716 | 0.183 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.664810 | 0.177 |
| R-HSA-977606 | Regulation of Complement cascade | 0.667466 | 0.176 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.690449 | 0.161 |
| R-HSA-1266738 | Developmental Biology | 0.699478 | 0.155 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.702490 | 0.153 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.702529 | 0.153 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.702529 | 0.153 |
| R-HSA-5368287 | Mitochondrial translation | 0.707229 | 0.150 |
| R-HSA-6807070 | PTEN Regulation | 0.709551 | 0.149 |
| R-HSA-9664407 | Parasite infection | 0.711855 | 0.148 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.711855 | 0.148 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.711855 | 0.148 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.714141 | 0.146 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.714144 | 0.146 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.718659 | 0.143 |
| R-HSA-166658 | Complement cascade | 0.725303 | 0.139 |
| R-HSA-9758941 | Gastrulation | 0.733921 | 0.134 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.738128 | 0.132 |
| R-HSA-73887 | Death Receptor Signaling | 0.744316 | 0.128 |
| R-HSA-9610379 | HCMV Late Events | 0.750359 | 0.125 |
| R-HSA-9711097 | Cellular response to starvation | 0.752342 | 0.124 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.752342 | 0.124 |
| R-HSA-8957322 | Metabolism of steroids | 0.757016 | 0.121 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.763914 | 0.117 |
| R-HSA-109582 | Hemostasis | 0.766042 | 0.116 |
| R-HSA-1474244 | Extracellular matrix organization | 0.766836 | 0.115 |
| R-HSA-5619102 | SLC transporter disorders | 0.769497 | 0.114 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.776738 | 0.110 |
| R-HSA-72306 | tRNA processing | 0.776738 | 0.110 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.780273 | 0.108 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.782020 | 0.107 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.782020 | 0.107 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.783753 | 0.106 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.787920 | 0.104 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.788005 | 0.103 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.790529 | 0.102 |
| R-HSA-2559583 | Cellular Senescence | 0.793868 | 0.100 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.798748 | 0.098 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.803513 | 0.095 |
| R-HSA-5663205 | Infectious disease | 0.803807 | 0.095 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.808641 | 0.092 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.818603 | 0.087 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.820649 | 0.086 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.824312 | 0.084 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.824312 | 0.084 |
| R-HSA-428157 | Sphingolipid metabolism | 0.825711 | 0.083 |
| R-HSA-2262752 | Cellular responses to stress | 0.834903 | 0.078 |
| R-HSA-9679506 | SARS-CoV Infections | 0.836227 | 0.078 |
| R-HSA-162582 | Signal Transduction | 0.848999 | 0.071 |
| R-HSA-9748784 | Drug ADME | 0.849087 | 0.071 |
| R-HSA-418990 | Adherens junctions interactions | 0.849087 | 0.071 |
| R-HSA-8951664 | Neddylation | 0.852668 | 0.069 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.860700 | 0.065 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.869323 | 0.061 |
| R-HSA-8939211 | ESR-mediated signaling | 0.870392 | 0.060 |
| R-HSA-421270 | Cell-cell junction organization | 0.884154 | 0.053 |
| R-HSA-449147 | Signaling by Interleukins | 0.888090 | 0.052 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.888709 | 0.051 |
| R-HSA-416476 | G alpha (q) signalling events | 0.895630 | 0.048 |
| R-HSA-382551 | Transport of small molecules | 0.902037 | 0.045 |
| R-HSA-446728 | Cell junction organization | 0.906731 | 0.043 |
| R-HSA-9658195 | Leishmania infection | 0.908952 | 0.041 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.908952 | 0.041 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.918646 | 0.037 |
| R-HSA-195721 | Signaling by WNT | 0.920586 | 0.036 |
| R-HSA-597592 | Post-translational protein modification | 0.922688 | 0.035 |
| R-HSA-1643685 | Disease | 0.922903 | 0.035 |
| R-HSA-392499 | Metabolism of proteins | 0.924882 | 0.034 |
| R-HSA-1500931 | Cell-Cell communication | 0.931298 | 0.031 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.944289 | 0.025 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.963699 | 0.016 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.964570 | 0.016 |
| R-HSA-8978868 | Fatty acid metabolism | 0.967326 | 0.014 |
| R-HSA-5668914 | Diseases of metabolism | 0.972217 | 0.012 |
| R-HSA-556833 | Metabolism of lipids | 0.982589 | 0.008 |
| R-HSA-1280218 | Adaptive Immune System | 0.991678 | 0.004 |
| R-HSA-500792 | GPCR ligand binding | 0.992586 | 0.003 |
| R-HSA-168256 | Immune System | 0.995855 | 0.002 |
| R-HSA-9709957 | Sensory Perception | 0.997742 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.998388 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 0.999192 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999686 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.782 | 0.157 | 1 | 0.872 |
IKKA |
0.781 | 0.211 | -2 | 0.738 |
COT |
0.780 | 0.173 | 2 | 0.857 |
BMPR1B |
0.778 | 0.309 | 1 | 0.805 |
GRK1 |
0.777 | 0.165 | -2 | 0.798 |
BMPR1A |
0.774 | 0.334 | 1 | 0.795 |
MOS |
0.774 | 0.187 | 1 | 0.854 |
GRK6 |
0.771 | 0.174 | 1 | 0.780 |
FAM20C |
0.771 | 0.140 | 2 | 0.623 |
TGFBR1 |
0.770 | 0.237 | -2 | 0.878 |
DSTYK |
0.769 | 0.100 | 2 | 0.837 |
CK2A2 |
0.769 | 0.258 | 1 | 0.795 |
IKKB |
0.768 | 0.034 | -2 | 0.752 |
CLK3 |
0.766 | 0.090 | 1 | 0.747 |
GRK7 |
0.765 | 0.197 | 1 | 0.709 |
ACVR2B |
0.765 | 0.259 | -2 | 0.879 |
GRK4 |
0.764 | 0.106 | -2 | 0.838 |
ACVR2A |
0.763 | 0.236 | -2 | 0.873 |
CAMK2G |
0.763 | 0.014 | 2 | 0.796 |
NDR2 |
0.762 | -0.014 | -3 | 0.618 |
ALK2 |
0.762 | 0.246 | -2 | 0.883 |
ATM |
0.762 | 0.104 | 1 | 0.734 |
RAF1 |
0.762 | 0.006 | 1 | 0.765 |
PRPK |
0.762 | -0.061 | -1 | 0.833 |
GCN2 |
0.761 | -0.008 | 2 | 0.771 |
PLK2 |
0.761 | 0.353 | -3 | 0.872 |
CK2A1 |
0.760 | 0.216 | 1 | 0.775 |
PIM3 |
0.760 | -0.008 | -3 | 0.616 |
BMPR2 |
0.760 | 0.056 | -2 | 0.899 |
ATR |
0.760 | 0.030 | 1 | 0.769 |
GRK5 |
0.759 | 0.013 | -3 | 0.700 |
TBK1 |
0.759 | -0.008 | 1 | 0.656 |
IKKE |
0.759 | 0.001 | 1 | 0.655 |
PLK3 |
0.758 | 0.206 | 2 | 0.769 |
NEK6 |
0.758 | 0.003 | -2 | 0.871 |
ALK4 |
0.758 | 0.161 | -2 | 0.896 |
CAMK2B |
0.758 | 0.036 | 2 | 0.796 |
TGFBR2 |
0.758 | 0.050 | -2 | 0.879 |
GSK3A |
0.758 | 0.025 | 4 | 0.500 |
PRKD1 |
0.756 | -0.028 | -3 | 0.586 |
NEK7 |
0.756 | -0.018 | -3 | 0.685 |
HUNK |
0.755 | -0.031 | 2 | 0.809 |
MTOR |
0.755 | -0.094 | 1 | 0.680 |
GSK3B |
0.754 | -0.022 | 4 | 0.500 |
PDHK4 |
0.753 | -0.211 | 1 | 0.762 |
PLK1 |
0.753 | 0.093 | -2 | 0.847 |
ERK5 |
0.753 | -0.010 | 1 | 0.722 |
CAMK1B |
0.753 | -0.072 | -3 | 0.648 |
KIS |
0.752 | 0.030 | 1 | 0.589 |
ULK2 |
0.750 | -0.132 | 2 | 0.755 |
MARK4 |
0.749 | -0.079 | 4 | 0.500 |
PDHK1 |
0.748 | -0.173 | 1 | 0.741 |
CAMK2A |
0.748 | -0.004 | 2 | 0.787 |
ULK1 |
0.748 | -0.101 | -3 | 0.670 |
TSSK2 |
0.747 | -0.029 | -5 | 0.634 |
SKMLCK |
0.747 | -0.043 | -2 | 0.846 |
NLK |
0.747 | -0.087 | 1 | 0.715 |
LATS2 |
0.747 | -0.059 | -5 | 0.572 |
LATS1 |
0.747 | 0.037 | -3 | 0.626 |
RSK2 |
0.747 | -0.039 | -3 | 0.549 |
PIM1 |
0.746 | -0.023 | -3 | 0.567 |
DAPK2 |
0.746 | -0.068 | -3 | 0.648 |
MARK2 |
0.745 | -0.042 | 4 | 0.500 |
PKN3 |
0.745 | -0.080 | -3 | 0.607 |
GRK2 |
0.745 | 0.065 | -2 | 0.734 |
BCKDK |
0.744 | -0.121 | -1 | 0.774 |
MLK1 |
0.744 | -0.067 | 2 | 0.756 |
CDKL1 |
0.744 | -0.085 | -3 | 0.590 |
MAPKAPK2 |
0.744 | -0.043 | -3 | 0.510 |
TSSK1 |
0.744 | -0.048 | -3 | 0.642 |
AMPKA1 |
0.742 | -0.109 | -3 | 0.627 |
PRKD2 |
0.742 | -0.063 | -3 | 0.540 |
DLK |
0.742 | -0.082 | 1 | 0.731 |
NDR1 |
0.741 | -0.105 | -3 | 0.607 |
CAMK2D |
0.741 | -0.122 | -3 | 0.613 |
NUAK2 |
0.741 | -0.114 | -3 | 0.623 |
TLK2 |
0.741 | 0.068 | 1 | 0.707 |
CAMLCK |
0.740 | -0.093 | -2 | 0.853 |
GRK3 |
0.740 | 0.072 | -2 | 0.695 |
P90RSK |
0.740 | -0.076 | -3 | 0.549 |
CDK8 |
0.740 | -0.017 | 1 | 0.566 |
P70S6KB |
0.739 | -0.066 | -3 | 0.574 |
NIK |
0.739 | -0.186 | -3 | 0.670 |
QSK |
0.739 | -0.068 | 4 | 0.500 |
DNAPK |
0.739 | 0.026 | 1 | 0.664 |
CHK1 |
0.738 | -0.026 | -3 | 0.637 |
MASTL |
0.738 | -0.239 | -2 | 0.790 |
MEK1 |
0.738 | -0.050 | 2 | 0.825 |
MSK1 |
0.737 | -0.028 | -3 | 0.526 |
ANKRD3 |
0.737 | -0.122 | 1 | 0.739 |
MARK3 |
0.737 | -0.062 | 4 | 0.500 |
JNK3 |
0.736 | 0.030 | 1 | 0.563 |
AURA |
0.736 | 0.020 | -2 | 0.646 |
RSK4 |
0.736 | -0.019 | -3 | 0.527 |
CDK1 |
0.736 | 0.024 | 1 | 0.543 |
AMPKA2 |
0.736 | -0.110 | -3 | 0.593 |
ICK |
0.735 | -0.080 | -3 | 0.615 |
CHAK2 |
0.735 | -0.097 | -1 | 0.813 |
HIPK4 |
0.735 | -0.091 | 1 | 0.654 |
JNK2 |
0.735 | 0.026 | 1 | 0.532 |
SMG1 |
0.734 | -0.023 | 1 | 0.722 |
RIPK3 |
0.734 | -0.189 | 3 | 0.578 |
RSK3 |
0.734 | -0.088 | -3 | 0.552 |
MSK2 |
0.733 | -0.077 | -3 | 0.526 |
BRAF |
0.733 | 0.021 | -4 | 0.783 |
WNK3 |
0.733 | -0.245 | 1 | 0.705 |
SIK |
0.733 | -0.086 | -3 | 0.549 |
MLK4 |
0.732 | 0.014 | 2 | 0.664 |
CAMK4 |
0.732 | -0.133 | -3 | 0.604 |
PKACG |
0.732 | -0.074 | -2 | 0.766 |
CDKL5 |
0.732 | -0.100 | -3 | 0.575 |
NEK9 |
0.732 | -0.201 | 2 | 0.781 |
MARK1 |
0.732 | -0.077 | 4 | 0.500 |
MST4 |
0.732 | -0.138 | 2 | 0.779 |
MLK3 |
0.731 | -0.062 | 2 | 0.671 |
BRSK1 |
0.731 | -0.088 | -3 | 0.565 |
MAPKAPK3 |
0.731 | -0.143 | -3 | 0.542 |
AURC |
0.731 | -0.028 | -2 | 0.689 |
PRKX |
0.731 | 0.014 | -3 | 0.462 |
PASK |
0.731 | 0.017 | -3 | 0.642 |
TTBK2 |
0.730 | -0.137 | 2 | 0.660 |
CDK19 |
0.730 | -0.029 | 1 | 0.528 |
CLK2 |
0.730 | 0.009 | -3 | 0.527 |
NUAK1 |
0.730 | -0.121 | -3 | 0.572 |
CDK5 |
0.730 | -0.010 | 1 | 0.600 |
SRPK1 |
0.730 | -0.083 | -3 | 0.524 |
MLK2 |
0.730 | -0.184 | 2 | 0.774 |
CK1E |
0.729 | -0.024 | -3 | 0.491 |
P38B |
0.729 | 0.005 | 1 | 0.548 |
PKCD |
0.728 | -0.103 | 2 | 0.721 |
PKACB |
0.728 | -0.018 | -2 | 0.707 |
P38D |
0.728 | 0.037 | 1 | 0.487 |
YSK4 |
0.728 | -0.112 | 1 | 0.685 |
PKN2 |
0.728 | -0.165 | -3 | 0.607 |
DRAK1 |
0.728 | -0.042 | 1 | 0.719 |
NIM1 |
0.727 | -0.166 | 3 | 0.653 |
TLK1 |
0.727 | -0.015 | -2 | 0.872 |
PINK1 |
0.727 | -0.065 | 1 | 0.700 |
P38A |
0.727 | -0.013 | 1 | 0.602 |
PKR |
0.727 | -0.094 | 1 | 0.712 |
CLK4 |
0.727 | -0.048 | -3 | 0.546 |
WNK1 |
0.726 | -0.231 | -2 | 0.846 |
SRPK2 |
0.726 | -0.074 | -3 | 0.467 |
CDK2 |
0.726 | -0.019 | 1 | 0.610 |
PRKD3 |
0.725 | -0.101 | -3 | 0.520 |
VRK2 |
0.725 | -0.263 | 1 | 0.743 |
DYRK2 |
0.725 | -0.054 | 1 | 0.564 |
ERK1 |
0.725 | -0.007 | 1 | 0.534 |
P38G |
0.725 | 0.008 | 1 | 0.458 |
IRE2 |
0.724 | -0.117 | 2 | 0.701 |
QIK |
0.724 | -0.196 | -3 | 0.617 |
PLK4 |
0.723 | -0.095 | 2 | 0.667 |
ERK2 |
0.723 | -0.027 | 1 | 0.567 |
AURB |
0.723 | -0.044 | -2 | 0.680 |
PERK |
0.723 | -0.086 | -2 | 0.886 |
JNK1 |
0.723 | 0.024 | 1 | 0.526 |
SSTK |
0.723 | -0.085 | 4 | 0.500 |
CDK7 |
0.723 | -0.081 | 1 | 0.586 |
PAK1 |
0.723 | -0.100 | -2 | 0.776 |
CK1D |
0.723 | -0.024 | -3 | 0.441 |
SRPK3 |
0.723 | -0.089 | -3 | 0.517 |
MEKK3 |
0.722 | -0.091 | 1 | 0.691 |
RIPK1 |
0.721 | -0.287 | 1 | 0.673 |
IRE1 |
0.721 | -0.205 | 1 | 0.648 |
MYLK4 |
0.721 | -0.090 | -2 | 0.785 |
GAK |
0.720 | 0.025 | 1 | 0.748 |
CDK18 |
0.720 | -0.042 | 1 | 0.511 |
CDK3 |
0.720 | 0.014 | 1 | 0.487 |
BRSK2 |
0.720 | -0.173 | -3 | 0.581 |
CLK1 |
0.720 | -0.061 | -3 | 0.523 |
MELK |
0.720 | -0.168 | -3 | 0.569 |
PRP4 |
0.719 | -0.061 | -3 | 0.543 |
CDK13 |
0.719 | -0.072 | 1 | 0.555 |
AKT2 |
0.718 | -0.069 | -3 | 0.477 |
MEKK1 |
0.718 | -0.112 | 1 | 0.689 |
MEKK2 |
0.718 | -0.066 | 2 | 0.768 |
CDK17 |
0.718 | -0.033 | 1 | 0.463 |
PAK3 |
0.718 | -0.153 | -2 | 0.776 |
HRI |
0.717 | -0.171 | -2 | 0.889 |
NEK2 |
0.717 | -0.209 | 2 | 0.742 |
PKG2 |
0.717 | -0.065 | -2 | 0.716 |
CHAK1 |
0.717 | -0.179 | 2 | 0.719 |
PAK2 |
0.716 | -0.131 | -2 | 0.762 |
CK1A2 |
0.716 | -0.042 | -3 | 0.440 |
ZAK |
0.716 | -0.143 | 1 | 0.657 |
DYRK4 |
0.716 | -0.024 | 1 | 0.509 |
MNK2 |
0.716 | -0.129 | -2 | 0.789 |
DAPK3 |
0.716 | -0.031 | -3 | 0.572 |
CK1G1 |
0.714 | -0.070 | -3 | 0.467 |
PAK6 |
0.714 | -0.079 | -2 | 0.710 |
CAMKK1 |
0.714 | -0.109 | -2 | 0.761 |
NEK5 |
0.714 | -0.165 | 1 | 0.714 |
MST2 |
0.714 | 0.007 | 1 | 0.724 |
TAO3 |
0.713 | -0.074 | 1 | 0.694 |
PKACA |
0.713 | -0.034 | -2 | 0.668 |
MEK5 |
0.713 | -0.261 | 2 | 0.792 |
DAPK1 |
0.713 | -0.033 | -3 | 0.559 |
DYRK1A |
0.712 | -0.077 | 1 | 0.620 |
PIM2 |
0.712 | -0.103 | -3 | 0.528 |
DCAMKL1 |
0.712 | -0.132 | -3 | 0.558 |
HIPK2 |
0.712 | -0.040 | 1 | 0.485 |
PKCB |
0.712 | -0.152 | 2 | 0.664 |
CAMK1D |
0.712 | -0.087 | -3 | 0.471 |
MNK1 |
0.711 | -0.127 | -2 | 0.807 |
MAPKAPK5 |
0.711 | -0.194 | -3 | 0.500 |
SMMLCK |
0.710 | -0.111 | -3 | 0.594 |
SGK3 |
0.710 | -0.110 | -3 | 0.528 |
P70S6K |
0.710 | -0.110 | -3 | 0.493 |
PKCG |
0.710 | -0.178 | 2 | 0.668 |
NEK8 |
0.709 | -0.140 | 2 | 0.753 |
CAMK1G |
0.709 | -0.147 | -3 | 0.543 |
PKCH |
0.709 | -0.171 | 2 | 0.662 |
CDK12 |
0.709 | -0.079 | 1 | 0.526 |
CDK16 |
0.709 | -0.038 | 1 | 0.483 |
PKCA |
0.709 | -0.162 | 2 | 0.650 |
TAK1 |
0.709 | -0.052 | 1 | 0.757 |
PHKG1 |
0.708 | -0.219 | -3 | 0.594 |
HIPK1 |
0.708 | -0.077 | 1 | 0.575 |
LKB1 |
0.707 | -0.163 | -3 | 0.633 |
DYRK1B |
0.707 | -0.064 | 1 | 0.532 |
SNRK |
0.707 | -0.257 | 2 | 0.657 |
PKCZ |
0.707 | -0.193 | 2 | 0.715 |
MPSK1 |
0.706 | -0.120 | 1 | 0.661 |
CAMKK2 |
0.706 | -0.158 | -2 | 0.756 |
CDK9 |
0.706 | -0.105 | 1 | 0.554 |
DCAMKL2 |
0.705 | -0.139 | -3 | 0.584 |
EEF2K |
0.704 | -0.084 | 3 | 0.654 |
AKT1 |
0.703 | -0.087 | -3 | 0.482 |
TTK |
0.702 | 0.077 | -2 | 0.868 |
TTBK1 |
0.702 | -0.176 | 2 | 0.584 |
CDK14 |
0.702 | -0.084 | 1 | 0.544 |
NEK11 |
0.702 | -0.241 | 1 | 0.687 |
MST3 |
0.702 | -0.188 | 2 | 0.760 |
IRAK4 |
0.702 | -0.249 | 1 | 0.657 |
ALPHAK3 |
0.701 | 0.102 | -1 | 0.770 |
WNK4 |
0.701 | -0.258 | -2 | 0.825 |
IRAK1 |
0.701 | -0.260 | -1 | 0.717 |
GCK |
0.701 | -0.107 | 1 | 0.718 |
MEK2 |
0.699 | -0.157 | 2 | 0.799 |
TAO2 |
0.699 | -0.195 | 2 | 0.783 |
PDK1 |
0.699 | -0.165 | 1 | 0.682 |
DYRK3 |
0.699 | -0.084 | 1 | 0.566 |
HIPK3 |
0.698 | -0.120 | 1 | 0.578 |
SBK |
0.697 | -0.076 | -3 | 0.374 |
SGK1 |
0.697 | -0.063 | -3 | 0.404 |
CK1A |
0.697 | -0.034 | -3 | 0.370 |
PAK5 |
0.697 | -0.097 | -2 | 0.637 |
PAK4 |
0.696 | -0.080 | -2 | 0.642 |
MST1 |
0.696 | -0.107 | 1 | 0.692 |
MINK |
0.696 | -0.152 | 1 | 0.693 |
VRK1 |
0.695 | -0.174 | 2 | 0.828 |
PHKG2 |
0.695 | -0.208 | -3 | 0.570 |
PKCT |
0.694 | -0.187 | 2 | 0.672 |
PDHK3_TYR |
0.693 | 0.108 | 4 | 0.500 |
AKT3 |
0.693 | -0.077 | -3 | 0.415 |
TNIK |
0.693 | -0.141 | 3 | 0.668 |
MRCKA |
0.693 | -0.095 | -3 | 0.527 |
CAMK1A |
0.693 | -0.105 | -3 | 0.440 |
OSR1 |
0.693 | -0.016 | 2 | 0.759 |
CHK2 |
0.692 | -0.121 | -3 | 0.423 |
MAP3K15 |
0.692 | -0.224 | 1 | 0.647 |
CDK6 |
0.691 | -0.074 | 1 | 0.526 |
NEK4 |
0.691 | -0.260 | 1 | 0.675 |
ERK7 |
0.691 | -0.084 | 2 | 0.427 |
MEKK6 |
0.690 | -0.267 | 1 | 0.690 |
MAK |
0.689 | -0.053 | -2 | 0.706 |
MAP2K6_TYR |
0.689 | 0.119 | -1 | 0.866 |
PDHK4_TYR |
0.689 | 0.095 | 2 | 0.850 |
CDK10 |
0.689 | -0.107 | 1 | 0.531 |
TXK |
0.689 | 0.232 | 1 | 0.830 |
BUB1 |
0.688 | -0.081 | -5 | 0.618 |
MRCKB |
0.688 | -0.097 | -3 | 0.512 |
PBK |
0.688 | -0.107 | 1 | 0.680 |
PDHK1_TYR |
0.688 | 0.123 | -1 | 0.886 |
HGK |
0.688 | -0.207 | 3 | 0.657 |
YANK3 |
0.688 | -0.065 | 2 | 0.381 |
CDK4 |
0.688 | -0.078 | 1 | 0.513 |
ROCK2 |
0.688 | -0.098 | -3 | 0.552 |
LRRK2 |
0.687 | -0.277 | 2 | 0.787 |
SLK |
0.687 | -0.135 | -2 | 0.714 |
RIPK2 |
0.687 | -0.264 | 1 | 0.630 |
NEK1 |
0.686 | -0.267 | 1 | 0.674 |
HPK1 |
0.684 | -0.194 | 1 | 0.700 |
MAP2K4_TYR |
0.684 | 0.005 | -1 | 0.854 |
FER |
0.684 | 0.126 | 1 | 0.833 |
PKCI |
0.683 | -0.216 | 2 | 0.673 |
BIKE |
0.683 | -0.046 | 1 | 0.626 |
DMPK1 |
0.683 | -0.073 | -3 | 0.534 |
PKG1 |
0.683 | -0.081 | -2 | 0.645 |
BLK |
0.683 | 0.185 | -1 | 0.834 |
BMPR2_TYR |
0.683 | 0.065 | -1 | 0.849 |
LOK |
0.682 | -0.206 | -2 | 0.769 |
PKN1 |
0.682 | -0.172 | -3 | 0.500 |
EPHB2 |
0.682 | 0.145 | -1 | 0.833 |
EPHB4 |
0.682 | 0.094 | -1 | 0.844 |
PKCE |
0.682 | -0.170 | 2 | 0.646 |
EPHA4 |
0.682 | 0.095 | 2 | 0.760 |
EPHA6 |
0.681 | 0.077 | -1 | 0.852 |
KHS1 |
0.681 | -0.170 | 1 | 0.684 |
SRMS |
0.680 | 0.137 | 1 | 0.817 |
EPHB1 |
0.680 | 0.095 | 1 | 0.797 |
YES1 |
0.680 | 0.119 | -1 | 0.841 |
KHS2 |
0.680 | -0.146 | 1 | 0.701 |
CRIK |
0.679 | -0.091 | -3 | 0.486 |
LCK |
0.678 | 0.127 | -1 | 0.822 |
CK1G3 |
0.678 | -0.035 | -3 | 0.326 |
FYN |
0.677 | 0.181 | -1 | 0.800 |
ABL2 |
0.677 | 0.082 | -1 | 0.815 |
TESK1_TYR |
0.677 | -0.164 | 3 | 0.720 |
MOK |
0.676 | -0.113 | 1 | 0.591 |
STK33 |
0.676 | -0.227 | 2 | 0.595 |
INSRR |
0.676 | 0.059 | 3 | 0.611 |
YSK1 |
0.676 | -0.246 | 2 | 0.733 |
EPHB3 |
0.675 | 0.054 | -1 | 0.828 |
MAP2K7_TYR |
0.675 | -0.193 | 2 | 0.828 |
HCK |
0.674 | 0.064 | -1 | 0.818 |
NEK3 |
0.673 | -0.282 | 1 | 0.632 |
STLK3 |
0.673 | -0.119 | 1 | 0.638 |
FGR |
0.673 | 0.010 | 1 | 0.771 |
EPHA5 |
0.673 | 0.117 | 2 | 0.756 |
PINK1_TYR |
0.672 | -0.144 | 1 | 0.741 |
ASK1 |
0.671 | -0.217 | 1 | 0.639 |
ROCK1 |
0.671 | -0.116 | -3 | 0.522 |
TEC |
0.671 | 0.069 | -1 | 0.724 |
LYN |
0.671 | 0.109 | 3 | 0.549 |
RET |
0.670 | -0.073 | 1 | 0.685 |
CSF1R |
0.670 | 0.010 | 3 | 0.621 |
TYRO3 |
0.670 | -0.064 | 3 | 0.640 |
ABL1 |
0.670 | 0.031 | -1 | 0.803 |
BMX |
0.669 | 0.056 | -1 | 0.720 |
PKMYT1_TYR |
0.669 | -0.225 | 3 | 0.680 |
EPHA7 |
0.669 | 0.051 | 2 | 0.753 |
ROS1 |
0.668 | -0.089 | 3 | 0.614 |
SYK |
0.668 | 0.143 | -1 | 0.789 |
DDR1 |
0.667 | -0.145 | 4 | 0.500 |
ITK |
0.667 | 0.038 | -1 | 0.788 |
MYO3A |
0.667 | -0.170 | 1 | 0.647 |
PTK2 |
0.667 | 0.124 | -1 | 0.783 |
AAK1 |
0.666 | -0.024 | 1 | 0.530 |
MST1R |
0.666 | -0.131 | 3 | 0.652 |
TYK2 |
0.666 | -0.160 | 1 | 0.690 |
CK1G2 |
0.666 | -0.028 | -3 | 0.404 |
EPHA3 |
0.666 | -0.010 | 2 | 0.733 |
JAK2 |
0.665 | -0.124 | 1 | 0.686 |
MET |
0.665 | 0.014 | 3 | 0.635 |
TAO1 |
0.665 | -0.207 | 1 | 0.612 |
MERTK |
0.665 | 0.013 | 3 | 0.626 |
EPHA8 |
0.665 | 0.088 | -1 | 0.813 |
KIT |
0.665 | -0.010 | 3 | 0.632 |
MYO3B |
0.664 | -0.209 | 2 | 0.742 |
SRC |
0.664 | 0.098 | -1 | 0.799 |
FRK |
0.664 | 0.062 | -1 | 0.837 |
FGFR2 |
0.664 | -0.035 | 3 | 0.660 |
JAK3 |
0.664 | -0.066 | 1 | 0.679 |
FLT3 |
0.662 | -0.028 | 3 | 0.614 |
HASPIN |
0.662 | -0.143 | -1 | 0.639 |
BTK |
0.662 | -0.021 | -1 | 0.749 |
LIMK2_TYR |
0.661 | -0.229 | -3 | 0.672 |
TEK |
0.660 | -0.092 | 3 | 0.597 |
NTRK1 |
0.660 | -0.042 | -1 | 0.826 |
EGFR |
0.660 | 0.044 | 1 | 0.582 |
ERBB2 |
0.660 | -0.026 | 1 | 0.664 |
LIMK1_TYR |
0.659 | -0.276 | 2 | 0.806 |
EPHA2 |
0.659 | 0.064 | -1 | 0.786 |
ALK |
0.659 | -0.045 | 3 | 0.588 |
FGFR1 |
0.659 | -0.086 | 3 | 0.636 |
PTK2B |
0.658 | 0.014 | -1 | 0.759 |
PTK6 |
0.658 | -0.020 | -1 | 0.717 |
FGFR3 |
0.658 | -0.013 | 3 | 0.640 |
INSR |
0.658 | -0.035 | 3 | 0.580 |
LTK |
0.657 | -0.042 | 3 | 0.601 |
TNK2 |
0.657 | -0.108 | 3 | 0.608 |
AXL |
0.656 | -0.092 | 3 | 0.639 |
YANK2 |
0.656 | -0.084 | 2 | 0.394 |
PDGFRB |
0.656 | -0.109 | 3 | 0.646 |
FGFR4 |
0.656 | 0.049 | -1 | 0.789 |
NTRK3 |
0.655 | -0.028 | -1 | 0.784 |
NTRK2 |
0.654 | -0.064 | 3 | 0.606 |
MATK |
0.654 | 0.002 | -1 | 0.758 |
KDR |
0.654 | -0.095 | 3 | 0.597 |
FLT1 |
0.653 | -0.030 | -1 | 0.847 |
ERBB4 |
0.653 | 0.039 | 1 | 0.631 |
EPHA1 |
0.653 | -0.075 | 3 | 0.615 |
CSK |
0.652 | 0.030 | 2 | 0.753 |
NEK10_TYR |
0.651 | -0.137 | 1 | 0.607 |
JAK1 |
0.650 | -0.126 | 1 | 0.632 |
IGF1R |
0.650 | -0.009 | 3 | 0.542 |
PDGFRA |
0.648 | -0.196 | 3 | 0.642 |
DDR2 |
0.646 | -0.093 | 3 | 0.609 |
FLT4 |
0.646 | -0.109 | 3 | 0.586 |
TNNI3K_TYR |
0.644 | -0.188 | 1 | 0.668 |
TNK1 |
0.643 | -0.216 | 3 | 0.612 |
FES |
0.641 | -0.014 | -1 | 0.693 |
WEE1_TYR |
0.640 | -0.162 | -1 | 0.719 |
MUSK |
0.628 | -0.141 | 1 | 0.567 |
ZAP70 |
0.625 | -0.013 | -1 | 0.700 |