Motif 1145 (n=56)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5A3E0 | POTEF | S932 | ochoa | POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) | None |
| O14983 | ATP2A1 | S346 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15226 | NKRF | S91 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O60271 | SPAG9 | S730 | ochoa|psp | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O75717 | WDHD1 | S367 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
| O95490 | ADGRL2 | S1409 | ochoa | Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity). {ECO:0000250|UniProtKB:Q80TS3, ECO:0000250|UniProtKB:Q8JZZ7}. |
| O95721 | SNAP29 | S163 | ochoa | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions. {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:25686604}. |
| P05023 | ATP1A1 | S371 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05023 | ATP1A1 | S452 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P06241 | FYN | Y185 | ochoa|psp | Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:11536198, PubMed:15489916, PubMed:15557120, PubMed:16387660, PubMed:20100835, PubMed:7568038, PubMed:7822789). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (PubMed:15489916). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (PubMed:15489916). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (PubMed:17194753). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (PubMed:14707117, PubMed:15536091). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (PubMed:16841086). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (PubMed:14761972, PubMed:18258597, PubMed:19179337). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (PubMed:11162638, PubMed:12788081, PubMed:19652227). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (PubMed:22080863). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (PubMed:20028775). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (PubMed:18056706). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (PubMed:11005864). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (PubMed:15713798). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:15713798, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789, ECO:0000303|PubMed:15489916}. |
| P06733 | ENO1 | S370 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07947 | YES1 | Y194 | ochoa | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (PubMed:26979622). {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032, ECO:0000269|PubMed:26979622}. |
| P09769 | FGR | Y180 | ochoa | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P12931 | SRC | Y187 | ochoa | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P13637 | ATP1A3 | S361 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P13637 | ATP1A3 | S442 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P13929 | ENO3 | S370 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P16284 | PECAM1 | S700 | ochoa|psp | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}. |
| P16615 | ATP2A2 | S346 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P35348 | ADRA1A | S220 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P42858 | HTT | S455 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P50993 | ATP1A2 | S369 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P50993 | ATP1A2 | S450 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. {ECO:0000269|PubMed:33880529}. |
| P60709 | ACTB | S232 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | S234 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63241 | EIF5A | S44 | ochoa | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}. |
| P63261 | ACTG1 | S232 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | S233 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | S234 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | S234 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| Q13464 | ROCK1 | S456 | psp | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. |
| Q13733 | ATP1A4 | S379 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. |
| Q16659 | MAPK6 | S511 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q6S8J3 | POTEE | S932 | ochoa | POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) | None |
| Q71DI3 | H3C15 | S97 | ochoa | Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q7L9B9 | EEPD1 | S173 | ochoa | Endonuclease/exonuclease/phosphatase family domain-containing protein 1 | None |
| Q86W56 | PARG | S130 | ochoa | Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) | Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:15450800, ECO:0000269|PubMed:21892188, ECO:0000269|PubMed:23102699, ECO:0000269|PubMed:23474714, ECO:0000269|PubMed:23481255, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:34019811, ECO:0000269|PubMed:34321462}. |
| Q8N7R7 | CCNYL1 | S88 | ochoa | Cyclin-Y-like protein 1 | Key regulator of Wnt signaling implicated in various biological processes including male fertility, embryonic neurogenesis and cortex development. Activates the cyclin-dependent kinase CDK16, and promotes sperm maturation. {ECO:0000250|UniProtKB:D3YUJ3}. |
| Q8NAN2 | MIGA1 | S289 | ochoa | Mitoguardin 1 (Protein FAM73A) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q8ND76 | CCNY | S66 | ochoa | Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. {ECO:0000269|PubMed:18060517, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949, ECO:0000269|PubMed:22184064}. |
| Q8NFC6 | BOD1L1 | S1124 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NFY4 | SEMA6D | S710 | ochoa | Semaphorin-6D | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}. |
| Q93084 | ATP2A3 | S346 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Q96CN9 | GCC1 | S414 | ochoa | GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) | Probably involved in maintaining Golgi structure. |
| Q9BW71 | HIRIP3 | S300 | ochoa | HIRA-interacting protein 3 | Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin. {ECO:0000269|PubMed:38334665, ECO:0000269|PubMed:9710638}. |
| Q9GZV4 | EIF5A2 | S44 | ochoa | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}. |
| Q9H0H5 | RACGAP1 | S154 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H4L7 | SMARCAD1 | S173 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1) | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}. |
| Q9HCD6 | TANC2 | S235 | ochoa | Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}. |
| Q9HD26 | GOPC | S439 | ochoa | Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST) | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}. |
| Q9NWM3 | CUEDC1 | S351 | ochoa | CUE domain-containing protein 1 | None |
| Q9ULF5 | SLC39A10 | S608 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9UMY1 | NOL7 | S126 | ochoa | U3 small nucleolar RNA-associated protein NOL7 (U3 snoRNA-associated protein NOL7) (Nucleolar protein 7) (Nucleolar protein of 27 kDa) | Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing (PubMed:34516797, PubMed:37246770). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA (PubMed:37246770). Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability (PubMed:37246770). {ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:37246770}. |
| Q9Y485 | DMXL1 | S429 | ochoa | DmX-like protein 1 (X-like 1 protein) | None |
| Q9Y4F1 | FARP1 | S896 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4P8 | WIPI2 | S390 | ochoa | WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:30968111}.; FUNCTION: [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. {ECO:0000269|PubMed:24954904}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9764561 | Regulation of CDH1 Function | 2.240452e-10 | 9.650 |
| R-HSA-397014 | Muscle contraction | 1.715267e-09 | 8.766 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 8.936867e-09 | 8.049 |
| R-HSA-5578775 | Ion homeostasis | 7.132733e-09 | 8.147 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.587623e-08 | 7.799 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.580195e-08 | 7.182 |
| R-HSA-1500931 | Cell-Cell communication | 7.390195e-08 | 7.131 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 6.448296e-08 | 7.191 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 6.448296e-08 | 7.191 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.664888e-07 | 6.779 |
| R-HSA-210990 | PECAM1 interactions | 3.266437e-07 | 6.486 |
| R-HSA-418990 | Adherens junctions interactions | 3.875443e-07 | 6.412 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 9.905324e-07 | 6.004 |
| R-HSA-421270 | Cell-cell junction organization | 1.128075e-06 | 5.948 |
| R-HSA-5576891 | Cardiac conduction | 1.868417e-06 | 5.729 |
| R-HSA-446728 | Cell junction organization | 2.443068e-06 | 5.612 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.770356e-06 | 5.557 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.221004e-06 | 5.492 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 9.538325e-06 | 5.021 |
| R-HSA-983712 | Ion channel transport | 1.762096e-05 | 4.754 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 3.078069e-05 | 4.512 |
| R-HSA-9664407 | Parasite infection | 3.626022e-05 | 4.441 |
| R-HSA-9664417 | Leishmania phagocytosis | 3.626022e-05 | 4.441 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 3.626022e-05 | 4.441 |
| R-HSA-1433559 | Regulation of KIT signaling | 5.274599e-05 | 4.278 |
| R-HSA-109582 | Hemostasis | 5.957195e-05 | 4.225 |
| R-HSA-418346 | Platelet homeostasis | 1.042949e-04 | 3.982 |
| R-HSA-162582 | Signal Transduction | 1.071637e-04 | 3.970 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.122150e-04 | 3.950 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 1.229547e-04 | 3.910 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.385868e-04 | 3.858 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.575898e-04 | 3.802 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.930849e-04 | 3.714 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.930849e-04 | 3.714 |
| R-HSA-194138 | Signaling by VEGF | 2.295900e-04 | 3.639 |
| R-HSA-422475 | Axon guidance | 3.473599e-04 | 3.459 |
| R-HSA-418360 | Platelet calcium homeostasis | 3.698453e-04 | 3.432 |
| R-HSA-1474244 | Extracellular matrix organization | 4.442938e-04 | 3.352 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.255022e-04 | 3.279 |
| R-HSA-157118 | Signaling by NOTCH | 5.477186e-04 | 3.261 |
| R-HSA-9675108 | Nervous system development | 5.485586e-04 | 3.261 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.846882e-04 | 3.233 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 7.166573e-04 | 3.145 |
| R-HSA-2029481 | FCGR activation | 7.380864e-04 | 3.132 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 8.863953e-04 | 3.052 |
| R-HSA-196025 | Formation of annular gap junctions | 8.863953e-04 | 3.052 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 9.761422e-04 | 3.010 |
| R-HSA-5674135 | MAP2K and MAPK activation | 9.761422e-04 | 3.010 |
| R-HSA-390696 | Adrenoceptors | 8.863953e-04 | 3.052 |
| R-HSA-190873 | Gap junction degradation | 1.052231e-03 | 2.978 |
| R-HSA-204626 | Hypusine synthesis from eIF5A-lysine | 1.052231e-03 | 2.978 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.094524e-03 | 2.961 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.288493e-03 | 2.890 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.288493e-03 | 2.890 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.288493e-03 | 2.890 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.288493e-03 | 2.890 |
| R-HSA-9658195 | Leishmania infection | 1.165030e-03 | 2.934 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.165030e-03 | 2.934 |
| R-HSA-437239 | Recycling pathway of L1 | 1.357639e-03 | 2.867 |
| R-HSA-389356 | Co-stimulation by CD28 | 1.429079e-03 | 2.845 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.501886e-03 | 2.823 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.502840e-03 | 2.823 |
| R-HSA-418885 | DCC mediated attractive signaling | 2.591855e-03 | 2.586 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.591855e-03 | 2.586 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 2.321217e-03 | 2.634 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.475045e-03 | 2.606 |
| R-HSA-373755 | Semaphorin interactions | 2.794000e-03 | 2.554 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.020073e-03 | 2.520 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.136773e-03 | 2.504 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.238475e-03 | 2.490 |
| R-HSA-3928664 | Ephrin signaling | 3.760081e-03 | 2.425 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.760081e-03 | 2.425 |
| R-HSA-912631 | Regulation of signaling by CBL | 4.083892e-03 | 2.389 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 5.908994e-03 | 2.228 |
| R-HSA-416482 | G alpha (12/13) signalling events | 4.763720e-03 | 2.322 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 4.768917e-03 | 2.322 |
| R-HSA-5663205 | Infectious disease | 5.689314e-03 | 2.245 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.886223e-03 | 2.162 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.886223e-03 | 2.162 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 7.548928e-03 | 2.122 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 7.548928e-03 | 2.122 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 7.993343e-03 | 2.097 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 8.449291e-03 | 2.073 |
| R-HSA-354192 | Integrin signaling | 1.038653e-02 | 1.984 |
| R-HSA-390522 | Striated Muscle Contraction | 1.089875e-02 | 1.963 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 1.166941e-02 | 1.933 |
| R-HSA-8941326 | RUNX2 regulates bone development | 1.250088e-02 | 1.903 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 1.673871e-02 | 1.776 |
| R-HSA-373752 | Netrin-1 signaling | 1.787590e-02 | 1.748 |
| R-HSA-190828 | Gap junction trafficking | 1.787590e-02 | 1.748 |
| R-HSA-373760 | L1CAM interactions | 1.457870e-02 | 1.836 |
| R-HSA-375280 | Amine ligand-binding receptors | 1.787590e-02 | 1.748 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.660979e-02 | 1.780 |
| R-HSA-382551 | Transport of small molecules | 1.563567e-02 | 1.806 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.832057e-02 | 1.737 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 1.833588e-02 | 1.737 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.852389e-02 | 1.732 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.941591e-02 | 1.712 |
| R-HSA-70263 | Gluconeogenesis | 2.052653e-02 | 1.688 |
| R-HSA-9766229 | Degradation of CDH1 | 2.121336e-02 | 1.673 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.309762e-02 | 1.636 |
| R-HSA-191650 | Regulation of gap junction activity | 2.320479e-02 | 1.634 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 2.320479e-02 | 1.634 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.405491e-02 | 1.619 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.405491e-02 | 1.619 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 2.628273e-02 | 1.580 |
| R-HSA-177929 | Signaling by EGFR | 2.628273e-02 | 1.580 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 2.702039e-02 | 1.568 |
| R-HSA-8866376 | Reelin signalling pathway | 2.702039e-02 | 1.568 |
| R-HSA-166520 | Signaling by NTRKs | 2.750947e-02 | 1.561 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.937793e-02 | 1.532 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 3.837940e-02 | 1.416 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.858682e-02 | 1.414 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.097761e-02 | 1.509 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 2.824678e-02 | 1.549 |
| R-HSA-418886 | Netrin mediated repulsion signals | 3.837940e-02 | 1.416 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.947229e-02 | 1.404 |
| R-HSA-164944 | Nef and signal transduction | 3.460764e-02 | 1.461 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.597754e-02 | 1.444 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.069165e-02 | 1.390 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.036548e-02 | 1.394 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.302328e-02 | 1.481 |
| R-HSA-1266738 | Developmental Biology | 3.930641e-02 | 1.406 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.540529e-02 | 1.451 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 2.781277e-02 | 1.556 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.126633e-02 | 1.384 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 4.213666e-02 | 1.375 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.401414e-02 | 1.356 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 4.587947e-02 | 1.338 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 4.587947e-02 | 1.338 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 4.587947e-02 | 1.338 |
| R-HSA-9659379 | Sensory processing of sound | 4.588301e-02 | 1.338 |
| R-HSA-199991 | Membrane Trafficking | 4.656041e-02 | 1.332 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.682833e-02 | 1.329 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 4.960789e-02 | 1.304 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 4.960789e-02 | 1.304 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 4.960789e-02 | 1.304 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.166114e-02 | 1.287 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 5.332196e-02 | 1.273 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 5.364254e-02 | 1.270 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 5.470807e-02 | 1.262 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 5.702176e-02 | 1.244 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 6.803596e-02 | 1.167 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 7.530832e-02 | 1.123 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 8.252483e-02 | 1.083 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 9.324580e-02 | 1.030 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.073488e-01 | 0.969 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 6.437870e-02 | 1.191 |
| R-HSA-3214842 | HDMs demethylate histones | 1.143192e-01 | 0.942 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 7.261952e-02 | 1.139 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 7.530832e-02 | 1.123 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 9.324580e-02 | 1.030 |
| R-HSA-373753 | Nephrin family interactions | 9.324580e-02 | 1.030 |
| R-HSA-3214847 | HATs acetylate histones | 6.932165e-02 | 1.159 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 6.070732e-02 | 1.217 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 6.437870e-02 | 1.191 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 7.167915e-02 | 1.145 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.288297e-02 | 1.201 |
| R-HSA-171007 | p38MAPK events | 7.167915e-02 | 1.145 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.143192e-01 | 0.942 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.143192e-01 | 0.942 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.143192e-01 | 0.942 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 6.437870e-02 | 1.191 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.003245e-01 | 0.999 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 6.803596e-02 | 1.167 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 7.167915e-02 | 1.145 |
| R-HSA-167044 | Signalling to RAS | 9.679198e-02 | 1.014 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 6.803596e-02 | 1.167 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.050703e-02 | 1.094 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.003245e-01 | 0.999 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 1.108407e-01 | 0.955 |
| R-HSA-9620244 | Long-term potentiation | 1.143192e-01 | 0.942 |
| R-HSA-416700 | Other semaphorin interactions | 7.167915e-02 | 1.145 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.049281e-01 | 0.979 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 6.316955e-02 | 1.199 |
| R-HSA-391160 | Signal regulatory protein family interactions | 6.803596e-02 | 1.167 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 7.167915e-02 | 1.145 |
| R-HSA-180292 | GAB1 signalosome | 8.611228e-02 | 1.065 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.108407e-01 | 0.955 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 1.143192e-01 | 0.942 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 7.484608e-02 | 1.126 |
| R-HSA-435354 | Zinc transporters | 6.803596e-02 | 1.167 |
| R-HSA-1266695 | Interleukin-7 signaling | 1.143192e-01 | 0.942 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.747029e-02 | 1.058 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 1.073488e-01 | 0.969 |
| R-HSA-70326 | Glucose metabolism | 9.340666e-02 | 1.030 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 9.460786e-02 | 1.024 |
| R-HSA-70171 | Glycolysis | 7.041527e-02 | 1.152 |
| R-HSA-168249 | Innate Immune System | 7.893213e-02 | 1.103 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 9.581359e-02 | 1.019 |
| R-HSA-9679506 | SARS-CoV Infections | 7.479967e-02 | 1.126 |
| R-HSA-6798695 | Neutrophil degranulation | 1.173365e-01 | 0.931 |
| R-HSA-8874081 | MET activates PTK2 signaling | 1.177842e-01 | 0.929 |
| R-HSA-525793 | Myogenesis | 1.177842e-01 | 0.929 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 1.177842e-01 | 0.929 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 1.177842e-01 | 0.929 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.212360e-01 | 0.916 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 1.212360e-01 | 0.916 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.246744e-01 | 0.904 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.259125e-01 | 0.900 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.272788e-01 | 0.895 |
| R-HSA-1632852 | Macroautophagy | 1.272788e-01 | 0.895 |
| R-HSA-5334118 | DNA methylation | 1.280996e-01 | 0.892 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.280996e-01 | 0.892 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.312061e-01 | 0.882 |
| R-HSA-2424491 | DAP12 signaling | 1.315115e-01 | 0.881 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 1.315115e-01 | 0.881 |
| R-HSA-112311 | Neurotransmitter clearance | 1.315115e-01 | 0.881 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.349104e-01 | 0.870 |
| R-HSA-186763 | Downstream signal transduction | 1.349104e-01 | 0.870 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.382962e-01 | 0.859 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.416689e-01 | 0.849 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.416689e-01 | 0.849 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.416689e-01 | 0.849 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.450286e-01 | 0.839 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.458383e-01 | 0.836 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 1.483754e-01 | 0.829 |
| R-HSA-5673000 | RAF activation | 1.483754e-01 | 0.829 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.483754e-01 | 0.829 |
| R-HSA-392518 | Signal amplification | 1.483754e-01 | 0.829 |
| R-HSA-5205647 | Mitophagy | 1.483754e-01 | 0.829 |
| R-HSA-9612973 | Autophagy | 1.485351e-01 | 0.828 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.509604e-01 | 0.821 |
| R-HSA-187687 | Signalling to ERKs | 1.517093e-01 | 0.819 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.517093e-01 | 0.819 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.550303e-01 | 0.810 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.550303e-01 | 0.810 |
| R-HSA-8853659 | RET signaling | 1.550303e-01 | 0.810 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 1.583386e-01 | 0.800 |
| R-HSA-9824446 | Viral Infection Pathways | 1.605575e-01 | 0.794 |
| R-HSA-8875878 | MET promotes cell motility | 1.616341e-01 | 0.791 |
| R-HSA-201556 | Signaling by ALK | 1.649169e-01 | 0.783 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.681870e-01 | 0.774 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.681870e-01 | 0.774 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.681870e-01 | 0.774 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.688069e-01 | 0.773 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.704560e-01 | 0.768 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.714446e-01 | 0.766 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.714446e-01 | 0.766 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.714446e-01 | 0.766 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.714446e-01 | 0.766 |
| R-HSA-9607240 | FLT3 Signaling | 1.714446e-01 | 0.766 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.746896e-01 | 0.758 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 1.746896e-01 | 0.758 |
| R-HSA-9710421 | Defective pyroptosis | 1.811421e-01 | 0.742 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.811421e-01 | 0.742 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.811421e-01 | 0.742 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.843497e-01 | 0.734 |
| R-HSA-2172127 | DAP12 interactions | 1.843497e-01 | 0.734 |
| R-HSA-69236 | G1 Phase | 1.843497e-01 | 0.734 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.843497e-01 | 0.734 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.875449e-01 | 0.727 |
| R-HSA-5654741 | Signaling by FGFR3 | 1.875449e-01 | 0.727 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.907278e-01 | 0.720 |
| R-HSA-75153 | Apoptotic execution phase | 1.907278e-01 | 0.720 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.938985e-01 | 0.712 |
| R-HSA-9634597 | GPER1 signaling | 1.970569e-01 | 0.705 |
| R-HSA-425410 | Metal ion SLC transporters | 1.970569e-01 | 0.705 |
| R-HSA-912446 | Meiotic recombination | 2.064593e-01 | 0.685 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.095693e-01 | 0.679 |
| R-HSA-1643685 | Disease | 2.162572e-01 | 0.665 |
| R-HSA-3214815 | HDACs deacetylate histones | 2.188274e-01 | 0.660 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.218897e-01 | 0.654 |
| R-HSA-5621480 | Dectin-2 family | 2.249402e-01 | 0.648 |
| R-HSA-1483166 | Synthesis of PA | 2.249402e-01 | 0.648 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.279789e-01 | 0.642 |
| R-HSA-983189 | Kinesins | 2.340211e-01 | 0.631 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 2.340211e-01 | 0.631 |
| R-HSA-186797 | Signaling by PDGF | 2.400168e-01 | 0.620 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.400168e-01 | 0.620 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.503087e-01 | 0.602 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.518700e-01 | 0.599 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.577282e-01 | 0.589 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.619075e-01 | 0.582 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 2.635412e-01 | 0.579 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 2.635412e-01 | 0.579 |
| R-HSA-8939211 | ESR-mediated signaling | 2.662598e-01 | 0.575 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.664309e-01 | 0.574 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 2.693094e-01 | 0.570 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.750332e-01 | 0.561 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.807128e-01 | 0.552 |
| R-HSA-5689603 | UCH proteinases | 2.807128e-01 | 0.552 |
| R-HSA-4839726 | Chromatin organization | 2.836686e-01 | 0.547 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.863486e-01 | 0.543 |
| R-HSA-216083 | Integrin cell surface interactions | 2.863486e-01 | 0.543 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.919410e-01 | 0.535 |
| R-HSA-6806834 | Signaling by MET | 2.919410e-01 | 0.535 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.919410e-01 | 0.535 |
| R-HSA-977225 | Amyloid fiber formation | 2.947210e-01 | 0.531 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.974902e-01 | 0.527 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.029966e-01 | 0.519 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.029966e-01 | 0.519 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.039412e-01 | 0.517 |
| R-HSA-416476 | G alpha (q) signalling events | 3.053864e-01 | 0.515 |
| R-HSA-1500620 | Meiosis | 3.057339e-01 | 0.515 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.138824e-01 | 0.503 |
| R-HSA-438064 | Post NMDA receptor activation events | 3.138824e-01 | 0.503 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.165776e-01 | 0.500 |
| R-HSA-9663891 | Selective autophagy | 3.165776e-01 | 0.500 |
| R-HSA-73884 | Base Excision Repair | 3.219367e-01 | 0.492 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.246007e-01 | 0.489 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.246007e-01 | 0.489 |
| R-HSA-391251 | Protein folding | 3.298980e-01 | 0.482 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.325312e-01 | 0.478 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.325312e-01 | 0.478 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.429628e-01 | 0.465 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.429628e-01 | 0.465 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.429628e-01 | 0.465 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 3.455455e-01 | 0.461 |
| R-HSA-190236 | Signaling by FGFR | 3.481183e-01 | 0.458 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.557769e-01 | 0.449 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.583100e-01 | 0.446 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.583100e-01 | 0.446 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 3.658508e-01 | 0.437 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 3.658508e-01 | 0.437 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.683449e-01 | 0.434 |
| R-HSA-211000 | Gene Silencing by RNA | 3.733043e-01 | 0.428 |
| R-HSA-388396 | GPCR downstream signalling | 3.780474e-01 | 0.422 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 3.782254e-01 | 0.422 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.892426e-01 | 0.410 |
| R-HSA-1280218 | Adaptive Immune System | 4.063112e-01 | 0.391 |
| R-HSA-68875 | Mitotic Prophase | 4.092980e-01 | 0.388 |
| R-HSA-168256 | Immune System | 4.107972e-01 | 0.386 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.116239e-01 | 0.385 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.162486e-01 | 0.381 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.162486e-01 | 0.381 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.185476e-01 | 0.378 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.231188e-01 | 0.374 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.231188e-01 | 0.374 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.231188e-01 | 0.374 |
| R-HSA-114608 | Platelet degranulation | 4.276546e-01 | 0.369 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.299093e-01 | 0.367 |
| R-HSA-1474165 | Reproduction | 4.366212e-01 | 0.360 |
| R-HSA-73894 | DNA Repair | 4.396578e-01 | 0.357 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.410525e-01 | 0.356 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.432553e-01 | 0.353 |
| R-HSA-372790 | Signaling by GPCR | 4.519199e-01 | 0.345 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.519813e-01 | 0.345 |
| R-HSA-449147 | Signaling by Interleukins | 4.659335e-01 | 0.332 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.752898e-01 | 0.323 |
| R-HSA-9824439 | Bacterial Infection Pathways | 4.801676e-01 | 0.319 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.835214e-01 | 0.316 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 4.852681e-01 | 0.314 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 4.890738e-01 | 0.311 |
| R-HSA-69306 | DNA Replication | 4.896116e-01 | 0.310 |
| R-HSA-9610379 | HCMV Late Events | 4.976220e-01 | 0.303 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.996052e-01 | 0.301 |
| R-HSA-109581 | Apoptosis | 5.074612e-01 | 0.295 |
| R-HSA-418555 | G alpha (s) signalling events | 5.265741e-01 | 0.279 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.284448e-01 | 0.277 |
| R-HSA-2559583 | Cellular Senescence | 5.431505e-01 | 0.265 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.485480e-01 | 0.261 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 5.591735e-01 | 0.252 |
| R-HSA-9609690 | HCMV Early Events | 5.712209e-01 | 0.243 |
| R-HSA-112316 | Neuronal System | 5.739453e-01 | 0.241 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.779690e-01 | 0.238 |
| R-HSA-376176 | Signaling by ROBO receptors | 5.829613e-01 | 0.234 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.829613e-01 | 0.234 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 5.829613e-01 | 0.234 |
| R-HSA-5357801 | Programmed Cell Death | 5.878956e-01 | 0.231 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.991864e-01 | 0.222 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.007744e-01 | 0.221 |
| R-HSA-162906 | HIV Infection | 6.223659e-01 | 0.206 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.281495e-01 | 0.202 |
| R-HSA-9609646 | HCMV Infection | 6.553690e-01 | 0.184 |
| R-HSA-5688426 | Deubiquitination | 6.621588e-01 | 0.179 |
| R-HSA-69278 | Cell Cycle, Mitotic | 6.738989e-01 | 0.171 |
| R-HSA-500792 | GPCR ligand binding | 6.944739e-01 | 0.158 |
| R-HSA-1483257 | Phospholipid metabolism | 7.119417e-01 | 0.148 |
| R-HSA-195721 | Signaling by WNT | 7.153698e-01 | 0.145 |
| R-HSA-1640170 | Cell Cycle | 7.846594e-01 | 0.105 |
| R-HSA-68886 | M Phase | 7.974417e-01 | 0.098 |
| R-HSA-74160 | Gene expression (Transcription) | 8.063432e-01 | 0.093 |
| R-HSA-418594 | G alpha (i) signalling events | 8.167906e-01 | 0.088 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.435637e-01 | 0.074 |
| R-HSA-212436 | Generic Transcription Pathway | 8.750904e-01 | 0.058 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.141231e-01 | 0.039 |
| R-HSA-9709957 | Sensory Perception | 9.622923e-01 | 0.017 |
| R-HSA-597592 | Post-translational protein modification | 9.663175e-01 | 0.015 |
| R-HSA-8953854 | Metabolism of RNA | 9.679750e-01 | 0.014 |
| R-HSA-2262752 | Cellular responses to stress | 9.850338e-01 | 0.007 |
| R-HSA-392499 | Metabolism of proteins | 9.900745e-01 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 9.979683e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999895e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDC7 |
0.709 | 0.149 | 1 | 0.798 |
MARK4 |
0.704 | 0.263 | 4 | 0.742 |
MARK3 |
0.702 | 0.300 | 4 | 0.782 |
COT |
0.698 | 0.029 | 2 | 0.704 |
BMPR1B |
0.698 | 0.178 | 1 | 0.801 |
HUNK |
0.696 | 0.149 | 2 | 0.674 |
MARK2 |
0.696 | 0.285 | 4 | 0.767 |
QSK |
0.695 | 0.216 | 4 | 0.753 |
MOS |
0.694 | 0.092 | 1 | 0.758 |
NUAK2 |
0.693 | 0.095 | -3 | 0.731 |
GCN2 |
0.689 | -0.077 | 2 | 0.638 |
MARK1 |
0.689 | 0.236 | 4 | 0.756 |
TSSK2 |
0.689 | 0.130 | -5 | 0.705 |
AMPKA1 |
0.687 | 0.124 | -3 | 0.735 |
TSSK1 |
0.687 | 0.134 | -3 | 0.754 |
DSTYK |
0.684 | -0.023 | 2 | 0.696 |
ACVR2B |
0.684 | 0.121 | -2 | 0.788 |
TGFBR2 |
0.684 | -0.000 | -2 | 0.792 |
PRPK |
0.684 | -0.041 | -1 | 0.496 |
QIK |
0.683 | 0.109 | -3 | 0.713 |
BRSK1 |
0.683 | 0.105 | -3 | 0.664 |
RAF1 |
0.683 | -0.037 | 1 | 0.664 |
WNK1 |
0.682 | 0.039 | -2 | 0.759 |
SSTK |
0.682 | 0.169 | 4 | 0.712 |
BMPR1A |
0.682 | 0.127 | 1 | 0.804 |
RIPK3 |
0.681 | -0.019 | 3 | 0.527 |
SKMLCK |
0.681 | 0.059 | -2 | 0.753 |
ACVR2A |
0.681 | 0.097 | -2 | 0.785 |
TGFBR1 |
0.681 | 0.090 | -2 | 0.787 |
ULK2 |
0.681 | -0.059 | 2 | 0.632 |
CLK3 |
0.681 | 0.016 | 1 | 0.637 |
CAMK1B |
0.681 | 0.010 | -3 | 0.738 |
SIK |
0.680 | 0.121 | -3 | 0.628 |
BMPR2 |
0.680 | -0.051 | -2 | 0.801 |
AMPKA2 |
0.680 | 0.093 | -3 | 0.697 |
NEK6 |
0.680 | -0.041 | -2 | 0.809 |
BRSK2 |
0.679 | 0.101 | -3 | 0.679 |
NIM1 |
0.678 | 0.035 | 3 | 0.588 |
NEK7 |
0.678 | -0.069 | -3 | 0.740 |
NUAK1 |
0.678 | 0.062 | -3 | 0.653 |
KIS |
0.678 | -0.001 | 1 | 0.427 |
IKKB |
0.677 | -0.111 | -2 | 0.685 |
ATR |
0.677 | 0.021 | 1 | 0.675 |
GRK5 |
0.677 | -0.051 | -3 | 0.804 |
GRK6 |
0.677 | 0.005 | 1 | 0.743 |
TBK1 |
0.676 | -0.062 | 1 | 0.514 |
ULK1 |
0.675 | -0.052 | -3 | 0.726 |
ALK2 |
0.675 | 0.076 | -2 | 0.795 |
GRK1 |
0.675 | 0.007 | -2 | 0.721 |
CHAK2 |
0.675 | -0.049 | -1 | 0.501 |
PIM3 |
0.675 | -0.047 | -3 | 0.727 |
NLK |
0.675 | -0.047 | 1 | 0.592 |
IKKE |
0.674 | -0.081 | 1 | 0.513 |
ALK4 |
0.674 | 0.056 | -2 | 0.796 |
PDHK4 |
0.674 | -0.142 | 1 | 0.651 |
MLK1 |
0.674 | -0.075 | 2 | 0.654 |
FAM20C |
0.674 | 0.000 | 2 | 0.426 |
GRK4 |
0.673 | -0.038 | -2 | 0.766 |
DAPK2 |
0.673 | 0.016 | -3 | 0.746 |
NIK |
0.673 | -0.029 | -3 | 0.769 |
MTOR |
0.673 | -0.093 | 1 | 0.538 |
CAMK2G |
0.672 | -0.076 | 2 | 0.612 |
PRKD1 |
0.672 | -0.023 | -3 | 0.691 |
HIPK4 |
0.670 | 0.004 | 1 | 0.573 |
CAMLCK |
0.670 | -0.016 | -2 | 0.731 |
IRE1 |
0.670 | -0.034 | 1 | 0.618 |
MAPKAPK3 |
0.670 | -0.035 | -3 | 0.628 |
PDHK1 |
0.669 | -0.136 | 1 | 0.613 |
ANKRD3 |
0.669 | -0.074 | 1 | 0.664 |
ATM |
0.669 | -0.010 | 1 | 0.649 |
NDR2 |
0.668 | -0.085 | -3 | 0.729 |
RSK2 |
0.668 | -0.026 | -3 | 0.640 |
PLK1 |
0.668 | -0.005 | -2 | 0.756 |
NEK9 |
0.668 | -0.075 | 2 | 0.667 |
CK1E |
0.667 | 0.055 | -3 | 0.603 |
WNK3 |
0.667 | -0.114 | 1 | 0.641 |
MELK |
0.667 | 0.005 | -3 | 0.669 |
MAPKAPK2 |
0.667 | -0.033 | -3 | 0.589 |
RIPK1 |
0.666 | -0.097 | 1 | 0.642 |
PKN2 |
0.666 | -0.052 | -3 | 0.731 |
SMG1 |
0.666 | 0.003 | 1 | 0.623 |
MST4 |
0.666 | -0.075 | 2 | 0.670 |
IKKA |
0.666 | -0.082 | -2 | 0.676 |
MYLK4 |
0.666 | 0.013 | -2 | 0.659 |
PRKD2 |
0.665 | -0.046 | -3 | 0.636 |
P90RSK |
0.665 | -0.037 | -3 | 0.648 |
PKN3 |
0.664 | -0.079 | -3 | 0.726 |
NDR1 |
0.664 | -0.087 | -3 | 0.713 |
MNK2 |
0.664 | -0.008 | -2 | 0.662 |
CDKL1 |
0.664 | -0.062 | -3 | 0.679 |
MLK3 |
0.664 | -0.071 | 2 | 0.589 |
GRK2 |
0.664 | 0.026 | -2 | 0.642 |
SRPK1 |
0.663 | -0.027 | -3 | 0.635 |
RSK3 |
0.663 | -0.037 | -3 | 0.641 |
DLK |
0.663 | -0.103 | 1 | 0.692 |
AURC |
0.663 | -0.009 | -2 | 0.525 |
CAMK2D |
0.663 | -0.065 | -3 | 0.705 |
PRP4 |
0.662 | 0.109 | -3 | 0.838 |
TLK1 |
0.662 | -0.003 | -2 | 0.801 |
ERK5 |
0.662 | -0.087 | 1 | 0.517 |
TLK2 |
0.662 | -0.016 | 1 | 0.666 |
MASTL |
0.661 | -0.145 | -2 | 0.734 |
SNRK |
0.661 | -0.045 | 2 | 0.564 |
CK2A2 |
0.661 | 0.037 | 1 | 0.728 |
BCKDK |
0.661 | -0.157 | -1 | 0.426 |
CLK2 |
0.661 | 0.031 | -3 | 0.635 |
CAMK4 |
0.661 | -0.072 | -3 | 0.699 |
PLK3 |
0.661 | -0.017 | 2 | 0.616 |
MLK2 |
0.660 | -0.114 | 2 | 0.641 |
CLK1 |
0.660 | 0.004 | -3 | 0.623 |
LATS1 |
0.660 | -0.025 | -3 | 0.730 |
NEK2 |
0.660 | -0.032 | 2 | 0.648 |
DRAK1 |
0.660 | 0.019 | 1 | 0.702 |
TTBK2 |
0.659 | -0.111 | 2 | 0.554 |
CLK4 |
0.659 | -0.013 | -3 | 0.649 |
CAMK2B |
0.659 | -0.053 | 2 | 0.571 |
MEK1 |
0.659 | -0.047 | 2 | 0.668 |
LATS2 |
0.659 | -0.083 | -5 | 0.608 |
CAMK2A |
0.658 | -0.034 | 2 | 0.602 |
CAMK1G |
0.658 | -0.005 | -3 | 0.625 |
GRK7 |
0.658 | -0.008 | 1 | 0.648 |
IRE2 |
0.657 | -0.068 | 2 | 0.625 |
CDK2 |
0.657 | -0.003 | 1 | 0.504 |
CK2A1 |
0.657 | 0.040 | 1 | 0.719 |
CDKL5 |
0.657 | -0.062 | -3 | 0.663 |
PKCD |
0.657 | -0.071 | 2 | 0.627 |
MLK4 |
0.657 | -0.087 | 2 | 0.579 |
CHAK1 |
0.657 | -0.097 | 2 | 0.624 |
YSK4 |
0.656 | -0.074 | 1 | 0.589 |
DYRK2 |
0.656 | -0.014 | 1 | 0.457 |
PRKD3 |
0.656 | -0.054 | -3 | 0.612 |
GRK3 |
0.656 | 0.017 | -2 | 0.614 |
PIM1 |
0.656 | -0.064 | -3 | 0.663 |
PKR |
0.656 | -0.086 | 1 | 0.662 |
CDK8 |
0.655 | -0.060 | 1 | 0.448 |
CHK1 |
0.655 | -0.029 | -3 | 0.685 |
PERK |
0.655 | -0.092 | -2 | 0.816 |
VRK2 |
0.654 | -0.100 | 1 | 0.675 |
CK1D |
0.654 | 0.040 | -3 | 0.560 |
PKACG |
0.654 | -0.070 | -2 | 0.589 |
PKCB |
0.654 | -0.049 | 2 | 0.589 |
HRI |
0.654 | -0.091 | -2 | 0.807 |
SRPK2 |
0.654 | -0.041 | -3 | 0.549 |
WNK4 |
0.654 | -0.030 | -2 | 0.758 |
P70S6KB |
0.654 | -0.081 | -3 | 0.661 |
PHKG1 |
0.654 | -0.088 | -3 | 0.701 |
CK1A2 |
0.653 | 0.044 | -3 | 0.557 |
CDK1 |
0.653 | -0.025 | 1 | 0.423 |
SRPK3 |
0.653 | -0.041 | -3 | 0.611 |
PAK3 |
0.653 | -0.065 | -2 | 0.646 |
CDK19 |
0.652 | -0.052 | 1 | 0.408 |
MNK1 |
0.652 | -0.042 | -2 | 0.664 |
DCAMKL1 |
0.652 | -0.027 | -3 | 0.670 |
MEKK3 |
0.652 | -0.067 | 1 | 0.626 |
CDK7 |
0.652 | -0.070 | 1 | 0.447 |
PAK1 |
0.652 | -0.057 | -2 | 0.637 |
GSK3B |
0.651 | -0.006 | 4 | 0.236 |
AURB |
0.651 | -0.032 | -2 | 0.520 |
PASK |
0.651 | 0.019 | -3 | 0.758 |
MSK2 |
0.650 | -0.068 | -3 | 0.608 |
ICK |
0.650 | -0.090 | -3 | 0.714 |
PKCZ |
0.649 | -0.070 | 2 | 0.626 |
CDK18 |
0.649 | -0.036 | 1 | 0.376 |
P38G |
0.649 | -0.015 | 1 | 0.327 |
MSK1 |
0.649 | -0.033 | -3 | 0.614 |
CDK5 |
0.649 | -0.046 | 1 | 0.475 |
JNK2 |
0.649 | -0.010 | 1 | 0.372 |
MAPKAPK5 |
0.649 | -0.088 | -3 | 0.569 |
CDK13 |
0.648 | -0.055 | 1 | 0.408 |
PKCG |
0.648 | -0.086 | 2 | 0.592 |
CK1G1 |
0.648 | 0.001 | -3 | 0.593 |
PLK4 |
0.648 | -0.072 | 2 | 0.514 |
NEK5 |
0.648 | -0.049 | 1 | 0.650 |
P38A |
0.648 | -0.023 | 1 | 0.426 |
DNAPK |
0.648 | -0.016 | 1 | 0.499 |
AURA |
0.648 | -0.026 | -2 | 0.510 |
MEKK2 |
0.647 | -0.064 | 2 | 0.631 |
RSK4 |
0.647 | -0.045 | -3 | 0.625 |
BRAF |
0.647 | -0.072 | -4 | 0.613 |
PKG2 |
0.646 | -0.041 | -2 | 0.515 |
PKACB |
0.646 | -0.033 | -2 | 0.535 |
MST3 |
0.646 | -0.027 | 2 | 0.681 |
GSK3A |
0.645 | -0.001 | 4 | 0.238 |
DAPK1 |
0.645 | 0.015 | -3 | 0.670 |
IRAK4 |
0.645 | -0.089 | 1 | 0.627 |
PAK2 |
0.645 | -0.078 | -2 | 0.632 |
MEK5 |
0.644 | -0.148 | 2 | 0.658 |
PAK6 |
0.644 | -0.046 | -2 | 0.585 |
PKCH |
0.644 | -0.086 | 2 | 0.583 |
P38D |
0.644 | -0.009 | 1 | 0.334 |
CDK3 |
0.644 | -0.010 | 1 | 0.355 |
DYRK4 |
0.643 | -0.004 | 1 | 0.393 |
DCAMKL2 |
0.643 | -0.043 | -3 | 0.679 |
JNK3 |
0.643 | -0.031 | 1 | 0.404 |
NEK8 |
0.643 | -0.093 | 2 | 0.664 |
MEKK1 |
0.643 | -0.141 | 1 | 0.627 |
HIPK1 |
0.643 | -0.029 | 1 | 0.468 |
PINK1 |
0.642 | -0.136 | 1 | 0.615 |
CDK12 |
0.642 | -0.050 | 1 | 0.377 |
DAPK3 |
0.642 | -0.008 | -3 | 0.681 |
SGK3 |
0.642 | -0.048 | -3 | 0.648 |
GAK |
0.642 | 0.008 | 1 | 0.663 |
AKT2 |
0.642 | -0.042 | -3 | 0.566 |
P38B |
0.642 | -0.024 | 1 | 0.350 |
PLK2 |
0.642 | 0.001 | -3 | 0.736 |
IRAK1 |
0.642 | -0.114 | -1 | 0.423 |
CDK17 |
0.642 | -0.049 | 1 | 0.335 |
ZAK |
0.642 | -0.133 | 1 | 0.609 |
CAMKK1 |
0.642 | -0.089 | -2 | 0.689 |
LKB1 |
0.641 | -0.005 | -3 | 0.757 |
SMMLCK |
0.641 | -0.050 | -3 | 0.692 |
PKCA |
0.641 | -0.097 | 2 | 0.584 |
CDK9 |
0.641 | -0.061 | 1 | 0.404 |
PHKG2 |
0.641 | -0.078 | -3 | 0.683 |
EEF2K |
0.640 | -0.001 | 3 | 0.624 |
CAMK1D |
0.640 | -0.034 | -3 | 0.541 |
HIPK2 |
0.639 | -0.037 | 1 | 0.383 |
DYRK1A |
0.639 | -0.040 | 1 | 0.493 |
ERK1 |
0.638 | -0.057 | 1 | 0.340 |
MPSK1 |
0.638 | -0.056 | 1 | 0.579 |
CAMKK2 |
0.638 | -0.057 | -2 | 0.679 |
NEK11 |
0.638 | -0.086 | 1 | 0.580 |
PRKX |
0.637 | -0.043 | -3 | 0.582 |
TAO3 |
0.637 | -0.099 | 1 | 0.607 |
CDK14 |
0.637 | -0.052 | 1 | 0.407 |
PDHK3_TYR |
0.637 | 0.067 | 4 | 0.570 |
PIM2 |
0.637 | -0.069 | -3 | 0.614 |
HIPK3 |
0.636 | -0.045 | 1 | 0.448 |
CAMK1A |
0.636 | -0.012 | -3 | 0.531 |
TAK1 |
0.636 | -0.050 | 1 | 0.678 |
PKCI |
0.636 | -0.066 | 2 | 0.602 |
TTBK1 |
0.636 | -0.129 | 2 | 0.489 |
CDK16 |
0.635 | -0.036 | 1 | 0.352 |
ERK2 |
0.634 | -0.086 | 1 | 0.406 |
ERK7 |
0.634 | -0.014 | 2 | 0.453 |
MEKK6 |
0.634 | -0.050 | 1 | 0.627 |
VRK1 |
0.634 | -0.039 | 2 | 0.690 |
DYRK3 |
0.634 | -0.033 | 1 | 0.471 |
DYRK1B |
0.633 | -0.040 | 1 | 0.429 |
BMPR2_TYR |
0.633 | 0.038 | -1 | 0.535 |
NEK4 |
0.633 | -0.068 | 1 | 0.590 |
PKCT |
0.632 | -0.096 | 2 | 0.581 |
MST2 |
0.632 | -0.082 | 1 | 0.626 |
TXK |
0.632 | 0.058 | 1 | 0.804 |
TAO2 |
0.632 | -0.108 | 2 | 0.671 |
GCK |
0.632 | -0.043 | 1 | 0.620 |
CHK2 |
0.631 | -0.043 | -3 | 0.514 |
PDHK4_TYR |
0.631 | 0.029 | 2 | 0.709 |
NEK1 |
0.631 | -0.036 | 1 | 0.620 |
PKACA |
0.631 | -0.038 | -2 | 0.484 |
HPK1 |
0.630 | -0.035 | 1 | 0.576 |
PDHK1_TYR |
0.630 | 0.004 | -1 | 0.515 |
MAP2K6_TYR |
0.630 | 0.006 | -1 | 0.508 |
JNK1 |
0.630 | -0.034 | 1 | 0.382 |
EPHA6 |
0.630 | 0.028 | -1 | 0.544 |
CDK10 |
0.630 | -0.060 | 1 | 0.397 |
PKCE |
0.629 | -0.062 | 2 | 0.586 |
STK33 |
0.628 | -0.095 | 2 | 0.491 |
CK1A |
0.628 | 0.021 | -3 | 0.489 |
LRRK2 |
0.628 | -0.098 | 2 | 0.681 |
AKT1 |
0.628 | -0.061 | -3 | 0.584 |
PAK5 |
0.627 | -0.066 | -2 | 0.525 |
MAP2K4_TYR |
0.627 | -0.071 | -1 | 0.498 |
MINK |
0.627 | -0.089 | 1 | 0.586 |
P70S6K |
0.627 | -0.103 | -3 | 0.563 |
RIPK2 |
0.627 | -0.147 | 1 | 0.541 |
PDK1 |
0.626 | -0.106 | 1 | 0.567 |
TESK1_TYR |
0.626 | -0.093 | 3 | 0.646 |
HGK |
0.626 | -0.086 | 3 | 0.626 |
PKMYT1_TYR |
0.625 | -0.080 | 3 | 0.609 |
MAP3K15 |
0.625 | -0.100 | 1 | 0.573 |
TNIK |
0.625 | -0.084 | 3 | 0.642 |
MAP2K7_TYR |
0.625 | -0.101 | 2 | 0.681 |
PAK4 |
0.624 | -0.063 | -2 | 0.532 |
PKN1 |
0.624 | -0.073 | -3 | 0.586 |
BUB1 |
0.623 | -0.035 | -5 | 0.619 |
MST1 |
0.623 | -0.099 | 1 | 0.594 |
MEK2 |
0.622 | -0.137 | 2 | 0.641 |
BLK |
0.621 | 0.006 | -1 | 0.506 |
TTK |
0.621 | -0.036 | -2 | 0.789 |
HCK |
0.621 | -0.037 | -1 | 0.494 |
CDK6 |
0.620 | -0.066 | 1 | 0.382 |
SRMS |
0.620 | -0.003 | 1 | 0.767 |
ITK |
0.620 | -0.020 | -1 | 0.456 |
KHS2 |
0.620 | -0.054 | 1 | 0.574 |
FGR |
0.620 | -0.033 | 1 | 0.699 |
ALPHAK3 |
0.619 | -0.025 | -1 | 0.462 |
LOK |
0.619 | -0.114 | -2 | 0.670 |
EPHB4 |
0.619 | -0.054 | -1 | 0.483 |
MRCKA |
0.619 | -0.058 | -3 | 0.620 |
NEK3 |
0.619 | -0.097 | 1 | 0.558 |
ROCK2 |
0.619 | -0.056 | -3 | 0.670 |
FER |
0.619 | -0.041 | 1 | 0.763 |
YSK1 |
0.618 | -0.102 | 2 | 0.640 |
LCK |
0.618 | -0.030 | -1 | 0.510 |
SLK |
0.618 | -0.107 | -2 | 0.626 |
ABL1 |
0.617 | -0.057 | -1 | 0.454 |
MRCKB |
0.617 | -0.061 | -3 | 0.612 |
EPHA4 |
0.617 | -0.009 | 2 | 0.625 |
TYRO3 |
0.617 | -0.091 | 3 | 0.552 |
SBK |
0.617 | -0.049 | -3 | 0.438 |
PBK |
0.616 | -0.057 | 1 | 0.571 |
PINK1_TYR |
0.616 | -0.205 | 1 | 0.666 |
LIMK2_TYR |
0.616 | -0.093 | -3 | 0.774 |
AKT3 |
0.616 | -0.056 | -3 | 0.507 |
HASPIN |
0.616 | -0.047 | -1 | 0.404 |
EPHB1 |
0.616 | -0.038 | 1 | 0.733 |
PTK2 |
0.615 | 0.053 | -1 | 0.544 |
ABL2 |
0.615 | -0.083 | -1 | 0.460 |
BMX |
0.615 | -0.030 | -1 | 0.409 |
CDK4 |
0.615 | -0.079 | 1 | 0.370 |
PKG1 |
0.615 | -0.050 | -2 | 0.437 |
KHS1 |
0.615 | -0.087 | 1 | 0.550 |
SGK1 |
0.615 | -0.053 | -3 | 0.488 |
EPHB2 |
0.615 | -0.034 | -1 | 0.477 |
DMPK1 |
0.614 | -0.019 | -3 | 0.645 |
FYN |
0.614 | 0.007 | -1 | 0.494 |
YES1 |
0.614 | -0.071 | -1 | 0.471 |
OSR1 |
0.613 | -0.103 | 2 | 0.628 |
ROS1 |
0.613 | -0.096 | 3 | 0.531 |
INSRR |
0.613 | -0.069 | 3 | 0.498 |
YANK3 |
0.612 | -0.045 | 2 | 0.317 |
CSF1R |
0.612 | -0.096 | 3 | 0.532 |
PTK2B |
0.611 | 0.008 | -1 | 0.436 |
EPHB3 |
0.611 | -0.067 | -1 | 0.476 |
LIMK1_TYR |
0.611 | -0.173 | 2 | 0.671 |
SYK |
0.611 | 0.039 | -1 | 0.507 |
TEC |
0.611 | -0.064 | -1 | 0.394 |
MERTK |
0.611 | -0.054 | 3 | 0.521 |
RET |
0.610 | -0.160 | 1 | 0.611 |
MST1R |
0.610 | -0.159 | 3 | 0.553 |
FRK |
0.609 | -0.054 | -1 | 0.496 |
JAK2 |
0.609 | -0.140 | 1 | 0.599 |
LYN |
0.609 | -0.051 | 3 | 0.488 |
TYK2 |
0.608 | -0.180 | 1 | 0.604 |
MYO3B |
0.608 | -0.074 | 2 | 0.658 |
JAK3 |
0.608 | -0.118 | 1 | 0.613 |
KIT |
0.608 | -0.100 | 3 | 0.531 |
MET |
0.607 | -0.084 | 3 | 0.522 |
BIKE |
0.607 | -0.047 | 1 | 0.522 |
ROCK1 |
0.607 | -0.057 | -3 | 0.627 |
MOK |
0.607 | -0.077 | 1 | 0.472 |
TNNI3K_TYR |
0.607 | 0.003 | 1 | 0.596 |
DDR1 |
0.607 | -0.113 | 4 | 0.521 |
TNK2 |
0.605 | -0.123 | 3 | 0.466 |
KDR |
0.605 | -0.101 | 3 | 0.529 |
BTK |
0.605 | -0.131 | -1 | 0.414 |
SRC |
0.604 | -0.041 | -1 | 0.470 |
EPHA7 |
0.604 | -0.063 | 2 | 0.624 |
PTK6 |
0.604 | -0.127 | -1 | 0.388 |
MAK |
0.603 | -0.067 | -2 | 0.558 |
TAO1 |
0.603 | -0.119 | 1 | 0.518 |
FLT1 |
0.602 | -0.091 | -1 | 0.503 |
ALK |
0.602 | -0.099 | 3 | 0.486 |
AXL |
0.602 | -0.118 | 3 | 0.502 |
MYO3A |
0.602 | -0.113 | 1 | 0.579 |
FGFR2 |
0.602 | -0.118 | 3 | 0.550 |
TEK |
0.602 | -0.118 | 3 | 0.483 |
CRIK |
0.602 | -0.067 | -3 | 0.576 |
ASK1 |
0.601 | -0.134 | 1 | 0.557 |
EPHA3 |
0.601 | -0.090 | 2 | 0.599 |
WEE1_TYR |
0.600 | -0.105 | -1 | 0.403 |
PDGFRB |
0.600 | -0.176 | 3 | 0.554 |
JAK1 |
0.599 | -0.098 | 1 | 0.529 |
FLT3 |
0.599 | -0.165 | 3 | 0.551 |
CK1G3 |
0.599 | -0.016 | -3 | 0.456 |
ERBB2 |
0.599 | -0.121 | 1 | 0.605 |
EPHA5 |
0.598 | -0.071 | 2 | 0.605 |
FGFR1 |
0.597 | -0.129 | 3 | 0.506 |
NEK10_TYR |
0.597 | -0.124 | 1 | 0.505 |
EPHA2 |
0.597 | -0.054 | -1 | 0.472 |
TNK1 |
0.596 | -0.126 | 3 | 0.547 |
LTK |
0.596 | -0.131 | 3 | 0.513 |
EPHA8 |
0.596 | -0.080 | -1 | 0.477 |
EPHA1 |
0.595 | -0.125 | 3 | 0.496 |
MATK |
0.595 | -0.100 | -1 | 0.410 |
INSR |
0.595 | -0.111 | 3 | 0.472 |
NTRK1 |
0.594 | -0.166 | -1 | 0.445 |
FGFR3 |
0.594 | -0.113 | 3 | 0.521 |
PDGFRA |
0.594 | -0.199 | 3 | 0.559 |
ERBB4 |
0.594 | -0.032 | 1 | 0.591 |
CK1G2 |
0.592 | -0.004 | -3 | 0.532 |
STLK3 |
0.592 | -0.155 | 1 | 0.581 |
EGFR |
0.592 | -0.078 | 1 | 0.544 |
FLT4 |
0.590 | -0.154 | 3 | 0.516 |
FES |
0.590 | -0.056 | -1 | 0.391 |
NTRK3 |
0.590 | -0.134 | -1 | 0.414 |
NTRK2 |
0.588 | -0.187 | 3 | 0.493 |
DDR2 |
0.588 | -0.080 | 3 | 0.485 |
AAK1 |
0.587 | -0.035 | 1 | 0.415 |
CSK |
0.586 | -0.127 | 2 | 0.629 |
FGFR4 |
0.586 | -0.106 | -1 | 0.440 |
ZAP70 |
0.585 | -0.031 | -1 | 0.454 |
MUSK |
0.584 | -0.120 | 1 | 0.517 |
IGF1R |
0.584 | -0.107 | 3 | 0.436 |
YANK2 |
0.583 | -0.055 | 2 | 0.322 |