Motif 1141 (n=130)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0MZ66 | SHTN1 | S619 | ochoa | Shootin-1 (Shootin1) | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}. |
| E9PCH4 | None | S1640 | ochoa | Rap guanine nucleotide exchange factor 6 | None |
| M0QYT0 | None | S309 | ochoa | RRM domain-containing protein | None |
| O43482 | OIP5 | S218 | ochoa | Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. |
| O60315 | ZEB2 | S1203 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O60814 | H2BC12 | S113 | ochoa | Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| O95232 | LUC7L3 | S420 | ochoa | Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) | Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269|PubMed:16462885}. |
| P00441 | SOD1 | S143 | ochoa | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P01889 | HLA-B | S350 | psp | HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B) | Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:23209413, PubMed:25808313, PubMed:29531227, PubMed:9620674). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:18991276, PubMed:7743181). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:24600035, PubMed:29531227, PubMed:9620674). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:23209413, ECO:0000269|PubMed:24600035, ECO:0000269|PubMed:25808313, ECO:0000269|PubMed:29531227, ECO:0000269|PubMed:7743181, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (SPRWYFYYL) (PubMed:32887977). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181). {ECO:0000269|PubMed:25808313, ECO:0000269|PubMed:29531227, ECO:0000269|PubMed:32887977, ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response. {ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with successful control of HIV-1 infection. {ECO:0000269|PubMed:17251285}.; FUNCTION: Allele B*18:01: Preferentially presents octomeric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:18991276, PubMed:23749632). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097). {ECO:0000269|PubMed:12366779, ECO:0000269|PubMed:14978097, ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:23749632}.; FUNCTION: Allele B*27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), SARS-CoV-2 N/nucleoprotein (QRNAPRITF), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), conferring longterm protection against viral infection (PubMed:15113903, PubMed:18385228, PubMed:19139562, PubMed:32887977, PubMed:9620674). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:15657948, PubMed:8879234). KIR3DL1 fails to recognize HLA-B*27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674). {ECO:0000269|PubMed:15113903, ECO:0000269|PubMed:15657948, ECO:0000269|PubMed:18385228, ECO:0000269|PubMed:19139562, ECO:0000269|PubMed:1922338, ECO:0000269|PubMed:8879234, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*40:01: Presents immunodominant viral epitopes derived from EBV/HHV-4 LMP2 (IEDPPFNSL) and SARS-CoV-2 N/nucleoprotein (MEVTPSGTWL), triggering memory CD8-positive T cell response (PubMed:18991276, PubMed:32887977). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:32887977}.; FUNCTION: Allele B*41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:18991276, PubMed:9620674). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276). {ECO:0000269|PubMed:18991276, ECO:0000269|PubMed:9620674}.; FUNCTION: Allele B*45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way. {ECO:0000269|PubMed:28514659}.; FUNCTION: Allele B*47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus. {ECO:0000269|PubMed:18991276}.; FUNCTION: Allele B*51:01: Presents an octomeric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication. {ECO:0000269|PubMed:24600035}.; FUNCTION: Allele B*54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}.; FUNCTION: Allele B*57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response. Presents HIV gag peptides (immunodominant KAFSPEVIPMF and subdominant KALGPAATL epitopes) predominantly to CD8-positive T cell clones expressing a TRAV41-containing TCR, triggering HLA-B-restricted T cell responses. {ECO:0000269|PubMed:22020283, ECO:0000269|PubMed:25480565, ECO:0000269|PubMed:34228645}.; FUNCTION: Allele B*67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus. {ECO:0000269|PubMed:7743181}. |
| P06737 | PYGL | S836 | ochoa | Glycogen phosphorylase, liver form (EC 2.4.1.1) | Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:22225877}. |
| P07550 | ADRB2 | S401 | psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P11169 | SLC2A3 | S485 | ochoa | Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) | Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:26176916, PubMed:9477959). Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P32037, ECO:0000269|PubMed:26176916, ECO:0000269|PubMed:32860739, ECO:0000269|PubMed:8457197, ECO:0000269|PubMed:9477959}. |
| P11233 | RALA | S194 | psp | Ras-related protein Ral-A (EC 3.6.5.2) | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors (PubMed:18756269, PubMed:19306925, PubMed:20005108, PubMed:21822277, PubMed:30500825). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (PubMed:21822277). {ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:20005108, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:30500825}. |
| P11717 | IGF2R | S2479 | ochoa | Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}. |
| P13747 | HLA-E | S347 | ochoa | HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)] | Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides - VMAPRT[V/L][L/V/I/F]L) (PubMed:18083576, PubMed:18339401, PubMed:35705051, PubMed:37264229, PubMed:9754572). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:17179229, PubMed:18083576, PubMed:37264229, PubMed:9486650, PubMed:9754572). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:30134159, PubMed:37264229, PubMed:9754572). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8-positive cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:20195504, PubMed:30087334, PubMed:34228645). Presents HIV gag peptides (immunodominant KAFSPEVIPMF and subdominant KALGPAATL epitopes) predominantly to CD8-positive T cell clones expressing a TRAV17-containing TCR, triggering HLA-E-restricted T cell responses (PubMed:34228645). Presents mycobacterial peptides to HLA-E-restricted CD8-positive T cells eliciting both cytotoxic and immunoregulatory functions (PubMed:20195504, PubMed:35705051). {ECO:0000269|PubMed:12461076, ECO:0000269|PubMed:16474394, ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:18083576, ECO:0000269|PubMed:18339401, ECO:0000269|PubMed:20195504, ECO:0000269|PubMed:30087334, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:34228645, ECO:0000269|PubMed:35705051, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9486650, ECO:0000269|PubMed:9754572}.; FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. {ECO:0000269|PubMed:10799855, ECO:0000269|PubMed:23335510}.; FUNCTION: (Microbial infection) May bind HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. {ECO:0000269|PubMed:15751767}.; FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32859121). Binds SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening of antiviral immune surveillance (PubMed:32859121). {ECO:0000269|PubMed:32859121}. |
| P14618 | PKM | S519 | ochoa | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| P15559 | NQO1 | S263 | ochoa | NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) | Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity) (PubMed:8999809, PubMed:9271353). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (PubMed:15102952, PubMed:8999809, PubMed:9271353). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (PubMed:8999809). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255, PubMed:28291250). {ECO:0000250|UniProtKB:P05982, ECO:0000269|PubMed:15102952, ECO:0000269|PubMed:15687255, ECO:0000269|PubMed:28291250, ECO:0000269|PubMed:8999809, ECO:0000269|PubMed:9271353}. |
| P15586 | GNS | S541 | ochoa | N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S) | Hydrolyzes 6-sulfate groups in N-acetyl-d-glucosaminide units of heparin sulfate and keratan sulfate. {ECO:0000269|PubMed:1463457}. |
| P15813 | CD1D | S323 | psp | Antigen-presenting glycoprotein CD1d (R3G1) (CD antigen CD1d) | Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:17475845}. |
| P15880 | RPS2 | S281 | ochoa | Small ribosomal subunit protein uS5 (40S ribosomal protein S2) (40S ribosomal protein S4) (Protein LLRep3) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399). Plays a role in the assembly and function of the 40S ribosomal subunit (By similarity). Mutations in this protein affects the control of translational fidelity (By similarity). Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250|UniProtKB:P25443, ECO:0000269|PubMed:23636399}. |
| P17612 | PRKACA | S339 | ochoa|psp | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| P17987 | TCP1 | S544 | ochoa|psp | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) (Chaperonin containing T-complex polypeptide 1 subunit 1) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P19429 | TNNI3 | S199 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P21583 | KITLG | S261 | ochoa | Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)] | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| P22626 | HNRNPA2B1 | S341 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P22694 | PRKACB | S339 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P25106 | ACKR3 | S350 | ochoa | Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1) | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (PubMed:16107333, PubMed:19255243, PubMed:19380869, PubMed:20161793, PubMed:22300987). Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway (PubMed:16940167, PubMed:18653785, PubMed:20018651). Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness (PubMed:16940167, PubMed:18653785). In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival (PubMed:16940167, PubMed:20388803). Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration (PubMed:17804806, PubMed:18653785, PubMed:19641136, PubMed:20887389). Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12 (PubMed:18653785). Required for heart valve development (PubMed:17804806). Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (PubMed:31211835). {ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:16940167, ECO:0000269|PubMed:17804806, ECO:0000269|PubMed:18653785, ECO:0000269|PubMed:19255243, ECO:0000269|PubMed:19380869, ECO:0000269|PubMed:19641136, ECO:0000269|PubMed:20018651, ECO:0000269|PubMed:20161793, ECO:0000269|PubMed:20388803, ECO:0000269|PubMed:20887389, ECO:0000269|PubMed:22300987, ECO:0000269|PubMed:31211835}.; FUNCTION: (Microbial infection) Acts as a coreceptor with CXCR4 for a restricted number of HIV isolates. {ECO:0000305|PubMed:23153575}. |
| P31949 | S100A11 | S94 | psp | Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed] | Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
| P32302 | CXCR5 | S361 | ochoa | C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185) | Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. |
| P35414 | APLNR | S369 | ochoa|psp | Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) | G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:11090199, PubMed:22810587, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:11090199, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G-protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy (PubMed:22810587, PubMed:38428423). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587, PubMed:38428423). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). {ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199, ECO:0000269|PubMed:22810587, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936, ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199). {ECO:0000269|PubMed:11090199}. |
| P37840 | SNCA | S129 | psp | Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). {ECO:0000269|PubMed:20798282, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:28288128, ECO:0000269|PubMed:30404828}. |
| P38936 | CDKN1A | S153 | psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P42226 | STAT6 | S835 | ochoa | Signal transducer and activator of transcription 6 (IL-4 Stat) | Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636, ECO:0000269|PubMed:36758835, ECO:0000269|PubMed:36884218}. |
| P48029 | SLC6A8 | S623 | ochoa | Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) | Creatine:sodium symporter which mediates the uptake of creatine (PubMed:17465020, PubMed:22644605, PubMed:25861866, PubMed:7945388, PubMed:7953292, PubMed:9882430). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). {ECO:0000250|UniProtKB:Q8VBW1, ECO:0000269|PubMed:17465020, ECO:0000269|PubMed:22644605, ECO:0000269|PubMed:25861866, ECO:0000269|PubMed:7945388, ECO:0000269|PubMed:7953292, ECO:0000269|PubMed:9882430}. |
| P48382 | RFX5 | S605 | ochoa | DNA-binding protein RFX5 (Regulatory factor X 5) | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
| P49146 | NPY2R | S369 | ochoa | Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) | Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. |
| P49354 | FNTA | S368 | ochoa | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) | Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}. |
| P50222 | MEOX2 | S292 | ochoa | Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2) | Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity). {ECO:0000250|UniProtKB:P32443, ECO:0000250|UniProtKB:P39020, ECO:0000269|PubMed:17074759, ECO:0000269|PubMed:20516212, ECO:0000269|PubMed:22206000}. |
| P51674 | GPM6A | S267 | ochoa | Neuronal membrane glycoprotein M6-a (M6a) | Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}. |
| P51991 | HNRNPA3 | S366 | ochoa | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:11886857}. |
| P55072 | VCP | S794 | ochoa | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000250|UniProtKB:P23787, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:16186510, ECO:0000269|PubMed:20104022, ECO:0000269|PubMed:21118995, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:22020440, ECO:0000269|PubMed:22120668, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26265139, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:26565908, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:29804830, ECO:0000269|PubMed:32152270, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:35013556}. |
| P56746 | CLDN15 | S217 | ochoa | Claudin-15 | Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:12055082, PubMed:13129853, PubMed:31188544, PubMed:35650657, PubMed:36008380). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q9Z0S5, ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853, ECO:0000269|PubMed:31188544, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}. |
| P57053 | H2BC12L | S113 | ochoa | Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P58876 | H2BC5 | S113 | ochoa | Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P60842 | EIF4A1 | S394 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P61026 | RAB10 | S188 | ochoa | Ras-related protein Rab-10 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372). In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280). Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148). When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (PubMed:30209220). {ECO:0000250|UniProtKB:P24409, ECO:0000250|UniProtKB:P61027, ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164, ECO:0000269|PubMed:23263280, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:32344433}.; FUNCTION: (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole. {ECO:0000269|PubMed:31540829}. |
| P61073 | CXCR4 | S341 | ochoa | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:18799424, PubMed:24912431, PubMed:28978524). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). {ECO:0000250|UniProtKB:P70658, ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10452968, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:17197449, ECO:0000269|PubMed:18799424, ECO:0000269|PubMed:20048153, ECO:0000269|PubMed:20228059, ECO:0000269|PubMed:20505072, ECO:0000269|PubMed:24912431, ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:8752280, ECO:0000269|PubMed:8752281}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:10074122, PubMed:10756055, PubMed:8849450, PubMed:8929542, PubMed:9427609). {ECO:0000269|PubMed:10074122, ECO:0000269|PubMed:10756055, ECO:0000269|PubMed:8849450, ECO:0000269|PubMed:8929542, ECO:0000269|PubMed:9427609}. |
| P62807 | H2BC4 | S113 | ochoa | Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| P68363 | TUBA1B | S439 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P78543 | BTG2 | S146 | ochoa | Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3) | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}. |
| P78552 | IL13RA1 | S415 | ochoa | Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1) | Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. |
| P98171 | ARHGAP4 | S934 | ochoa | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) | Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. |
| Q02221 | COX6A2 | S85 | ochoa | Cytochrome c oxidase subunit 6A2, mitochondrial (Cytochrome c oxidase polypeptide VIa-heart) (COXVIAH) (Cytochrome c oxidase subunit VIA-muscle) (COX VIa-M) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Plays a role in the assembly and stabilization of complex IV (PubMed:31155743). {ECO:0000250|UniProtKB:P32799, ECO:0000269|PubMed:31155743}. |
| Q06787 | FMR1 | S620 | ochoa | Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1) | Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of target mRNAs (PubMed:12417522, PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:12417522, PubMed:30765518, PubMed:31439799). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529). Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity). Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with CAPRIN1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (PubMed:31439799). Acts as a repressor of mRNA translation in synaptic regions by mediating formation of neuronal ribonucleoprotein granules and promoting recruitmtent of EIF4EBP2 (PubMed:30765518). Plays a role as a repressor of mRNA translation during the transport of dendritic mRNAs to postsynaptic dendritic spines (PubMed:11157796, PubMed:11532944, PubMed:12594214, PubMed:23235829). Component of the CYFIP1-EIF4E-FMR1 complex which blocks cap-dependent mRNA translation initiation (By similarity). Represses mRNA translation by stalling ribosomal translocation during elongation (By similarity). Reports are contradictory with regards to its ability to mediate translation inhibition of MBP mRNA in oligodendrocytes (PubMed:23891804). Also involved in the recruitment of the RNA helicase MOV10 to a subset of mRNAs and hence regulates microRNA (miRNA)-mediated translational repression by AGO2 (PubMed:14703574, PubMed:17057366, PubMed:25464849). Facilitates the assembly of miRNAs on specific target mRNAs (PubMed:17057366). Also plays a role as an activator of mRNA translation of a subset of dendritic mRNAs at synapses (PubMed:19097999, PubMed:19166269). In response to mGluR stimulation, FMR1-target mRNAs are rapidly derepressed, allowing for local translation at synapses (By similarity). Binds to a large subset of dendritic mRNAs that encode a myriad of proteins involved in pre- and postsynaptic functions (PubMed:11157796, PubMed:11719189, PubMed:12594214, PubMed:17417632, PubMed:23235829, PubMed:24448548, PubMed:7692601). Binds to 5'-ACU[GU]-3' and/or 5'-[AU]GGA-3' RNA consensus sequences within mRNA targets, mainly at coding sequence (CDS) and 3'-untranslated region (UTR) and less frequently at 5'-UTR (PubMed:23235829). Binds to intramolecular G-quadruplex structures in the 5'- or 3'-UTRs of mRNA targets (PubMed:11719189, PubMed:18579868, PubMed:25464849, PubMed:25692235). Binds to G-quadruplex structures in the 3'-UTR of its own mRNA (PubMed:11532944, PubMed:12594214, PubMed:15282548, PubMed:18653529, PubMed:7692601). Also binds to RNA ligands harboring a kissing complex (kc) structure; this binding may mediate the association of FMR1 with polyribosomes (PubMed:15805463). Binds mRNAs containing U-rich target sequences (PubMed:12927206). Binds to a triple stem-loop RNA structure, called Sod1 stem loop interacting with FMRP (SoSLIP), in the 5'-UTR region of superoxide dismutase SOD1 mRNA (PubMed:19166269). Binds to the dendritic, small non-coding brain cytoplasmic RNA 1 (BC1); which may increase the association of the CYFIP1-EIF4E-FMR1 complex to FMR1 target mRNAs at synapses (By similarity). Plays a role in mRNA nuclear export (PubMed:31753916). Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs, promoting their nuclear export in a XPO1/CRM1-dependent manner (PubMed:31753916). Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity). Associates with export factor NXF1 mRNA-containing ribonucleoprotein particles (mRNPs) in a NXF2-dependent manner (By similarity). Binds to a subset of miRNAs in the brain (PubMed:14703574, PubMed:17057366). May associate with nascent transcripts in a nuclear protein NXF1-dependent manner (PubMed:18936162). In vitro, binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:12950170, PubMed:15381419, PubMed:7688265, PubMed:7781595, PubMed:8156595). Moreover, plays a role in the modulation of the sodium-activated potassium channel KCNT1 gating activity (PubMed:20512134). Negatively regulates the voltage-dependent calcium channel current density in soma and presynaptic terminals of dorsal root ganglion (DRG) neurons, and hence regulates synaptic vesicle exocytosis (By similarity). Modulates the voltage-dependent calcium channel CACNA1B expression at the plasma membrane by targeting the channels for proteasomal degradation (By similarity). Plays a role in regulation of MAP1B-dependent microtubule dynamics during neuronal development (By similarity). Has been shown to play a translation-independent role in the modulation of presynaptic action potential (AP) duration and neurotransmitter release via large-conductance calcium-activated potassium (BK) channels in hippocampal and cortical excitatory neurons (PubMed:25561520). May be involved in the control of DNA damage response (DDR) mechanisms through the regulation of ATR-dependent signaling pathways such as histone H2AX/H2A.x and BRCA1 phosphorylations (PubMed:24813610). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates (PubMed:39106863). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:11157796, ECO:0000269|PubMed:11532944, ECO:0000269|PubMed:11719189, ECO:0000269|PubMed:12417522, ECO:0000269|PubMed:12594214, ECO:0000269|PubMed:12927206, ECO:0000269|PubMed:12950170, ECO:0000269|PubMed:14703574, ECO:0000269|PubMed:15282548, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15805463, ECO:0000269|PubMed:16631377, ECO:0000269|PubMed:17057366, ECO:0000269|PubMed:17417632, ECO:0000269|PubMed:18579868, ECO:0000269|PubMed:18653529, ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:19097999, ECO:0000269|PubMed:19166269, ECO:0000269|PubMed:20512134, ECO:0000269|PubMed:23235829, ECO:0000269|PubMed:23891804, ECO:0000269|PubMed:24448548, ECO:0000269|PubMed:24813610, ECO:0000269|PubMed:25464849, ECO:0000269|PubMed:25561520, ECO:0000269|PubMed:25692235, ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:31753916, ECO:0000269|PubMed:39106863, ECO:0000269|PubMed:7688265, ECO:0000269|PubMed:7692601, ECO:0000269|PubMed:7781595, ECO:0000269|PubMed:8156595}.; FUNCTION: [Isoform 10]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: [Isoform 6]: Binds to RNA homomer; preferentially on poly(G) and to a lesser extent on poly(U), but not on poly(A) or poly(C) (PubMed:24204304). May bind to RNA in Cajal bodies (PubMed:24204304). {ECO:0000269|PubMed:24204304}.; FUNCTION: (Microbial infection) Acts as a positive regulator of influenza A virus (IAV) replication. Required for the assembly and nuclear export of the viral ribonucleoprotein (vRNP) components. {ECO:0000269|PubMed:24514761}. |
| Q12929 | EPS8 | S811 | ochoa | Epidermal growth factor receptor kinase substrate 8 | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031}. |
| Q13217 | DNAJC3 | S492 | ochoa | DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58) | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}. |
| Q13451 | FKBP5 | S445 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}. |
| Q15022 | SUZ12 | S728 | ochoa | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q15061 | WDR43 | S666 | ochoa | WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) | Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q15185 | PTGES3 | S148 | ochoa | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Q16778 | H2BC21 | S113 | ochoa | Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Q16790 | CA9 | S448 | ochoa|psp | Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1) | Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). {ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18703501, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19805286}. |
| Q27J81 | INF2 | S1237 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q53EL6 | PDCD4 | S457 | ochoa|psp | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5IJ48 | CRB2 | S1274 | ochoa | Protein crumbs homolog 2 (Crumbs-like protein 2) | Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo (By similarity). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (By similarity). The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB (By similarity). Plays a role in the maintenance of retinal neuroepithelium organization, structural integrity, adhesion, photoreceptor polarity and retinal photoreceptor layer thickness (By similarity). May play a role in determining the length of cone photoreceptor outer segments and proliferation of late-born progenitor cells (By similarity). Also required for maintenance of the apical polarity complex during development of the cortex (By similarity). Inhibits gamma-secretase-dependent cleavage of APP and secretion of amyloid-beta peptide 40 and amyloid-beta peptide 42, and thereby inhibits gamma-secretase-dependent Notch transcription (PubMed:20299451). {ECO:0000250|UniProtKB:Q80YA8, ECO:0000269|PubMed:20299451}. |
| Q5QNW6 | H2BC18 | S113 | ochoa | Histone H2B type 2-F (H2B-clustered histone 18) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q5T9C2 | EEIG1 | S372 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5T9C2 | EEIG1 | S373 | ochoa | Early estrogen-induced gene 1 protein (EEIG1) | Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}. |
| Q5VW38 | GPR107 | S589 | ochoa | Protein GPR107 (Lung seven transmembrane receptor 1) | Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). {ECO:0000250|UniProtKB:D3ZWZ9, ECO:0000269|PubMed:22933024}.; FUNCTION: (Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum. {ECO:0000269|PubMed:25031321}. |
| Q5VZK9 | CARMIL1 | S1360 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q5W0B1 | OBI1 | S714 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q6NYC1 | JMJD6 | S390 | ochoa | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) | Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65 (PubMed:19574390). Hydroxylates its own N-terminus, which is required for homooligomerization (PubMed:22189873). Plays a role in the regulation of nucleolar liquid-liquid phase separation (LLPS) by post-translationally modifying LIAT1 at its lysine-rich domain which inhibits LIAT1 nucleolar targeting (By similarity). In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA (PubMed:20679243, PubMed:29176719). Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation (PubMed:17947579, PubMed:24360279, PubMed:24498420). Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code (PubMed:17947579, PubMed:24360279). However, histone arginine demethylation may not constitute the primary activity in vivo (PubMed:17947579, PubMed:21060799, PubMed:22189873). In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation (PubMed:24360279). Demethylates other arginine methylated-proteins such as ESR1 (PubMed:24498420). Has no histone lysine demethylase activity (PubMed:21060799). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65 (By similarity). Seems to be necessary for the regulation of macrophage cytokine responses (PubMed:15622002). {ECO:0000250|UniProtKB:Q9ERI5, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:17947579, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:20679243, ECO:0000269|PubMed:20684070, ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:22189873, ECO:0000269|PubMed:24360279, ECO:0000269|PubMed:24498420, ECO:0000269|PubMed:29176719}. |
| Q6NZI2 | CAVIN1 | S379 | ochoa | Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor) | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}. |
| Q6P4Q7 | CNNM4 | S764 | ochoa | Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4) | Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|PubMed:19200525, ECO:0000269|PubMed:19200527}. |
| Q6Q0C0 | TRAF7 | S658 | ochoa | E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7) | E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). {ECO:0000250|UniProtKB:Q922B6, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:29961569, ECO:0000269|PubMed:37086853}. |
| Q6ZNJ1 | NBEAL2 | S2742 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZS30 | NBEAL1 | S2682 | ochoa | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | None |
| Q71U36 | TUBA1A | S439 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L0Y3 | TRMT10C | S391 | ochoa | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}. |
| Q7L7X3 | TAOK1 | S990 | ochoa|psp | Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}. |
| Q7Z3C6 | ATG9A | S828 | ochoa | Autophagy-related protein 9A (APG9-like 1) (mATG9) | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27510922, ECO:0000269|PubMed:29437695, ECO:0000269|PubMed:30917996, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659, ECO:0000269|PubMed:33468622, ECO:0000269|PubMed:33850023}. |
| Q7Z460 | CLASP1 | S1526 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z4H7 | HAUS6 | S943 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z4S6 | KIF21A | S1662 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z5B4 | RIC3 | S358 | ochoa | Protein RIC-3 (Resistant to inhibitor of cholinesterase 3) | Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:32204458). May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. {ECO:0000269|PubMed:12821669, ECO:0000269|PubMed:15504725, ECO:0000269|PubMed:15809299, ECO:0000269|PubMed:15927954, ECO:0000269|PubMed:16120769, ECO:0000269|PubMed:17609200, ECO:0000269|PubMed:18691158, ECO:0000269|PubMed:32204458}. |
| Q86VQ0 | LCA5 | S686 | ochoa | Lebercilin (Leber congenital amaurosis 5 protein) | Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. {ECO:0000250|UniProtKB:Q80ST9}. |
| Q8IUH3 | RBM45 | S464 | ochoa | RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) | RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. {ECO:0000250|UniProtKB:Q8CFD1, ECO:0000269|PubMed:12220514}. |
| Q8N257 | H2BC26 | S113 | ochoa | Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q8NFZ8 | CADM4 | S377 | ochoa | Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) | Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity. {ECO:0000269|PubMed:16261159}. |
| Q8TB03 | CXorf38 | S307 | ochoa | Uncharacterized protein CXorf38 | None |
| Q8TED0 | UTP15 | S507 | ochoa | U3 small nucleolar RNA-associated protein 15 homolog | Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q8TEU7 | RAPGEF6 | S1590 | ochoa | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Q8WYK2 | JDP2 | S151 | ochoa | Jun dimerization protein 2 | Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}. |
| Q8WYR4 | RSPH1 | S297 | ochoa | Radial spoke head 1 homolog (Cancer/testis antigen 79) (CT79) (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) | Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. {ECO:0000269|PubMed:23993197}. |
| Q93079 | H2BC9 | S113 | ochoa | Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q96A08 | H2BC1 | S114 | ochoa | Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B) | Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133). {ECO:0000250|UniProtKB:P70696, ECO:0000269|PubMed:21249133}. |
| Q96FF7 | MISP3 | S208 | ochoa | Uncharacterized protein MISP3 (MISP family member 3) | None |
| Q96JK2 | DCAF5 | S931 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96K21 | ZFYVE19 | S460 | ochoa | Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) | Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}. |
| Q96KA5 | CLPTM1L | S526 | ochoa | Lipid scramblase CLPTM1L (Cisplatin resistance-related protein 9) (CRR9p) (Cleft lip and palate transmembrane protein 1-like protein) (CLPTM1-like protein) | Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI) (PubMed:35344438). GPI is a lipid glycoconjugate involved in post-translational modification of proteins (PubMed:35344438). Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro (PubMed:35344438). {ECO:0000269|PubMed:35344438}. |
| Q99877 | H2BC15 | S113 | ochoa | Histone H2B type 1-N (Histone H2B.d) (H2B/d) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99879 | H2BC14 | S113 | ochoa | Histone H2B type 1-M (Histone H2B.e) (H2B/e) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q99880 | H2BC13 | S113 | ochoa | Histone H2B type 1-L (Histone H2B.c) (H2B/c) | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Q9BPY8 | HOPX | S61 | ochoa | Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1) | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000269|PubMed:27708256}. |
| Q9BQE3 | TUBA1C | S439 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BWG6 | SCNM1 | S219 | ochoa | Sodium channel modifier 1 | As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:36084634). Plays a role in the regulation of primary cilia length and Hedgehog signaling (PubMed:36084634). {ECO:0000269|PubMed:36084634}. |
| Q9C0B5 | ZDHHC5 | S704 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9H0M4 | ZCWPW1 | S636 | ochoa | Zinc finger CW-type PWWP domain protein 1 | Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3) (PubMed:20826339, PubMed:32744506). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs) (By similarity). Essential for male fertility and spermatogenesis (By similarity). Required for meiosis prophase I progression in male but not in female germ cells (By similarity). {ECO:0000250|UniProtKB:Q6IR42, ECO:0000269|PubMed:20826339, ECO:0000269|PubMed:32744506}. |
| Q9H6L5 | RETREG1 | S486 | ochoa | Reticulophagy regulator 1 (Reticulophagy receptor 1) | Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720). {ECO:0000250|UniProtKB:Q8VE91, ECO:0000269|PubMed:19838196, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:34338405}.; FUNCTION: (Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269|PubMed:35239449}. |
| Q9NS64 | RPRM | S98 | psp | Protein reprimo | May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity). {ECO:0000250}. |
| Q9NT99 | LRRC4B | S702 | ochoa | Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3) | Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). {ECO:0000250}. |
| Q9NUN5 | LMBRD1 | S528 | ochoa | Lysosomal cobalamin transport escort protein LMBD1 (LMBD1) (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein) | Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed:19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed:27456980). Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K0B2, ECO:0000269|PubMed:19136951, ECO:0000269|PubMed:27456980, ECO:0000303|PubMed:25535791}.; FUNCTION: [Isoform 3]: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV). {ECO:0000269|PubMed:15956556}. |
| Q9NZQ7 | CD274 | S279 | ochoa|psp | Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274) | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417, ECO:0000269|PubMed:31399419, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:36727298}.; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28813410, PubMed:28813417). The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). {ECO:0000250|UniProtKB:Q9EP73, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}. |
| Q9UGP8 | SEC63 | S748 | psp | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UJX6 | ANAPC2 | S811 | ochoa | Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) | Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11739784, PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZQ7, ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
| Q9UKM9 | RALY | S295 | ochoa|psp | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9ULC8 | ZDHHC8 | S754 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULJ7 | ANKRD50 | S1417 | ochoa | Ankyrin repeat domain-containing protein 50 | Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). |
| Q9ULV4 | CORO1C | S463 | psp | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
| Q9UNH5 | CDC14A | S583 | ochoa|psp | Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}. |
| Q9UPI3 | FLVCR2 | S515 | ochoa | Choline/ethanolamine transporter FLVCR2 (Calcium-chelate transporter) (CCT) (Feline leukemia virus subgroup C receptor-related protein 2) (Heme transporter FLVCR2) | Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier (PubMed:38302740, PubMed:38778100). Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (By similarity). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (By similarity). Also mediates transport of ethanolamine (PubMed:38778100). Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane (PubMed:38778100). However, the presence of an inwardly directed proton gradient enhances choline uptake (By similarity). Also acts as a heme b transporter (PubMed:20823265, PubMed:32973183). Required to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis (PubMed:32973183). At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis (PubMed:32973183). Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis (PubMed:32973183). {ECO:0000250|UniProtKB:Q91X85, ECO:0000269|PubMed:20823265, ECO:0000269|PubMed:32973183, ECO:0000269|PubMed:38302740, ECO:0000269|PubMed:38778100}. |
| Q9UQ80 | PA2G4 | S383 | ochoa | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y394 | DHRS7 | S328 | ochoa | Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1) | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28457967, PubMed:28687384). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28457967, PubMed:28687384). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:26311046, ECO:0000269|PubMed:26466768, ECO:0000269|PubMed:28457967, ECO:0000269|PubMed:28687384}. |
| Q9Y5Q3 | MAFB | S311 | ochoa | Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B) | Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). {ECO:0000250|UniProtKB:P54841, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:27181683}. |
| Q9Y624 | F11R | S287 | ochoa | Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321) | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. {ECO:0000269|PubMed:11239401}.; FUNCTION: (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}. |
| P53634 | CTSC | S452 | Sugiyama | Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] | Thiol protease (PubMed:1586157). Has dipeptidylpeptidase activity (PubMed:1586157). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:1586157). Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1586157). Can act as both an exopeptidase and endopeptidase (PubMed:1586157). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (PubMed:8428921). {ECO:0000269|PubMed:1586157, ECO:0000269|PubMed:8428921}. |
| Q9BR61 | ACBD6 | S271 | Sugiyama | Acyl-CoA-binding domain-containing protein 6 | Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. Plays a role in protein N-myristoylation (PubMed:37951597). {ECO:0000269|PubMed:18268358, ECO:0000269|PubMed:37951597}. |
| Q15814 | TBCC | S334 | Sugiyama | Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC) | Tubulin-folding protein; involved in the final step of the tubulin folding pathway. {ECO:0000269|PubMed:11847227}. |
| Q96IR7 | HPDL | S360 | Sugiyama | 4-hydroxyphenylpyruvate dioxygenase-like protein (HPD-like protein) (HPDL) (EC 1.13.11.46) (Glyoxalase domain-containing protein 1) | Iron-dependent dioxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate (4-HPPA) to 4-hydroxymandelate (4-HMA) in the mitochondria, one of the steps in the biosynthesis of coenzyme Q10 from tyrosine. {ECO:0000269|PubMed:34471290}. |
| Q15118 | PDK1 | S424 | Sugiyama | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 5.551115e-16 | 15.256 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.661338e-16 | 15.176 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.776357e-15 | 14.750 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 1.110223e-15 | 14.955 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 1.776357e-15 | 14.750 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.220446e-15 | 14.654 |
| R-HSA-5334118 | DNA methylation | 3.441691e-15 | 14.463 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 4.773959e-15 | 14.321 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 8.992806e-15 | 14.046 |
| R-HSA-9710421 | Defective pyroptosis | 9.992007e-15 | 14.000 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 1.210143e-14 | 13.917 |
| R-HSA-774815 | Nucleosome assembly | 1.609823e-14 | 13.793 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.609823e-14 | 13.793 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.176037e-14 | 13.662 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 2.176037e-14 | 13.662 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.386980e-14 | 13.622 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.951595e-14 | 13.305 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.951595e-14 | 13.305 |
| R-HSA-73927 | Depurination | 6.428191e-14 | 13.192 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.064704e-13 | 12.973 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 1.064704e-13 | 12.973 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 1.358913e-13 | 12.867 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 1.358913e-13 | 12.867 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.179368e-13 | 12.662 |
| R-HSA-73928 | Depyrimidination | 2.179368e-13 | 12.662 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.304646e-13 | 12.275 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 5.191403e-13 | 12.285 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 6.791234e-13 | 12.168 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 8.067991e-13 | 12.093 |
| R-HSA-912446 | Meiotic recombination | 1.470934e-12 | 11.832 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.784350e-12 | 11.749 |
| R-HSA-1221632 | Meiotic synapsis | 2.157274e-12 | 11.666 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.157274e-12 | 11.666 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 2.599809e-12 | 11.585 |
| R-HSA-3214815 | HDACs deacetylate histones | 3.123279e-12 | 11.505 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 5.320189e-12 | 11.274 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.318057e-12 | 11.199 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.578849e-12 | 11.182 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.483125e-12 | 11.126 |
| R-HSA-977225 | Amyloid fiber formation | 1.001410e-11 | 10.999 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 1.350065e-11 | 10.870 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.388034e-11 | 10.858 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.747091e-11 | 10.758 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 1.899092e-11 | 10.721 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 1.899092e-11 | 10.721 |
| R-HSA-5693606 | DNA Double Strand Break Response | 2.284228e-11 | 10.641 |
| R-HSA-2559583 | Cellular Senescence | 2.605061e-11 | 10.584 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.654943e-11 | 10.576 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.863454e-11 | 10.543 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 3.564571e-11 | 10.448 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.832201e-11 | 10.417 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.117995e-11 | 10.385 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.117995e-11 | 10.385 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.748213e-11 | 10.323 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.935763e-11 | 10.227 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.277623e-11 | 10.202 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 8.240608e-11 | 10.084 |
| R-HSA-389948 | Co-inhibition by PD-1 | 1.119562e-10 | 9.951 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 1.391738e-10 | 9.856 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.580283e-10 | 9.801 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.630593e-10 | 9.788 |
| R-HSA-2262752 | Cellular responses to stress | 1.992780e-10 | 9.701 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.292855e-10 | 9.640 |
| R-HSA-1500620 | Meiosis | 2.588256e-10 | 9.587 |
| R-HSA-1474165 | Reproduction | 3.679723e-10 | 9.434 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.130511e-10 | 9.384 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 4.863157e-10 | 9.313 |
| R-HSA-73884 | Base Excision Repair | 5.206791e-10 | 9.283 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.444872e-10 | 9.264 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 5.824211e-10 | 9.235 |
| R-HSA-9609690 | HCMV Early Events | 7.393626e-10 | 9.131 |
| R-HSA-68886 | M Phase | 8.807336e-10 | 9.055 |
| R-HSA-8852135 | Protein ubiquitination | 1.117851e-09 | 8.952 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.346932e-09 | 8.871 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.346932e-09 | 8.871 |
| R-HSA-157579 | Telomere Maintenance | 1.369736e-09 | 8.863 |
| R-HSA-68875 | Mitotic Prophase | 1.392859e-09 | 8.856 |
| R-HSA-168256 | Immune System | 1.453464e-09 | 8.838 |
| R-HSA-73886 | Chromosome Maintenance | 1.521150e-09 | 8.818 |
| R-HSA-3214847 | HATs acetylate histones | 1.678196e-09 | 8.775 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.259122e-09 | 8.646 |
| R-HSA-421270 | Cell-cell junction organization | 2.690715e-09 | 8.570 |
| R-HSA-211000 | Gene Silencing by RNA | 3.992988e-09 | 8.399 |
| R-HSA-1640170 | Cell Cycle | 4.625834e-09 | 8.335 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.772122e-09 | 8.321 |
| R-HSA-69278 | Cell Cycle, Mitotic | 5.744475e-09 | 8.241 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.041325e-09 | 8.219 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.637549e-09 | 8.178 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 6.845277e-09 | 8.165 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 7.468043e-09 | 8.127 |
| R-HSA-446728 | Cell junction organization | 1.074531e-08 | 7.969 |
| R-HSA-5693538 | Homology Directed Repair | 1.239893e-08 | 7.907 |
| R-HSA-9609646 | HCMV Infection | 1.770045e-08 | 7.752 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.768519e-08 | 7.752 |
| R-HSA-418990 | Adherens junctions interactions | 2.279846e-08 | 7.642 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 2.346115e-08 | 7.630 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 2.346115e-08 | 7.630 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 2.346115e-08 | 7.630 |
| R-HSA-69306 | DNA Replication | 2.416285e-08 | 7.617 |
| R-HSA-69481 | G2/M Checkpoints | 2.734338e-08 | 7.563 |
| R-HSA-3247509 | Chromatin modifying enzymes | 5.277121e-08 | 7.278 |
| R-HSA-1500931 | Cell-Cell communication | 5.979649e-08 | 7.223 |
| R-HSA-447115 | Interleukin-12 family signaling | 6.069850e-08 | 7.217 |
| R-HSA-8939211 | ESR-mediated signaling | 6.134181e-08 | 7.212 |
| R-HSA-5689880 | Ub-specific processing proteases | 9.102307e-08 | 7.041 |
| R-HSA-4839726 | Chromatin organization | 1.097774e-07 | 6.959 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.984948e-07 | 6.702 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.110704e-07 | 6.676 |
| R-HSA-1280218 | Adaptive Immune System | 2.617474e-07 | 6.582 |
| R-HSA-5688426 | Deubiquitination | 8.643320e-07 | 6.063 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.124645e-06 | 5.949 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.812232e-06 | 5.742 |
| R-HSA-9610379 | HCMV Late Events | 1.866952e-06 | 5.729 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 5.389239e-06 | 5.268 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.219620e-06 | 5.085 |
| R-HSA-9824446 | Viral Infection Pathways | 1.048222e-05 | 4.980 |
| R-HSA-157118 | Signaling by NOTCH | 1.417133e-05 | 4.849 |
| R-HSA-195721 | Signaling by WNT | 2.187772e-05 | 4.660 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 3.378898e-05 | 4.471 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 3.378898e-05 | 4.471 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.570799e-05 | 4.447 |
| R-HSA-8963896 | HDL assembly | 3.659573e-05 | 4.437 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.725939e-05 | 4.326 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.861661e-05 | 4.232 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 7.892586e-05 | 4.103 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.289827e-04 | 3.889 |
| R-HSA-73894 | DNA Repair | 1.304879e-04 | 3.884 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.593940e-04 | 3.798 |
| R-HSA-1266738 | Developmental Biology | 2.294884e-04 | 3.639 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.573064e-04 | 3.590 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 2.573064e-04 | 3.590 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 3.279821e-04 | 3.484 |
| R-HSA-6798695 | Neutrophil degranulation | 3.499199e-04 | 3.456 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.747596e-04 | 3.324 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.385695e-04 | 3.269 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 5.640092e-04 | 3.249 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 7.090772e-04 | 3.149 |
| R-HSA-5663205 | Infectious disease | 8.084063e-04 | 3.092 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.169430e-04 | 3.088 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.513036e-04 | 3.022 |
| R-HSA-111933 | Calmodulin induced events | 9.823385e-04 | 3.008 |
| R-HSA-111997 | CaM pathway | 9.823385e-04 | 3.008 |
| R-HSA-8853659 | RET signaling | 9.823385e-04 | 3.008 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.029278e-03 | 2.987 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.078206e-03 | 2.967 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.129610e-03 | 2.947 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 1.129610e-03 | 2.947 |
| R-HSA-69275 | G2/M Transition | 1.158815e-03 | 2.936 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.231728e-03 | 2.909 |
| R-HSA-9646399 | Aggrephagy | 1.359579e-03 | 2.867 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.424941e-03 | 2.846 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.481752e-03 | 2.829 |
| R-HSA-163615 | PKA activation | 1.680844e-03 | 2.774 |
| R-HSA-164378 | PKA activation in glucagon signalling | 1.680844e-03 | 2.774 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.680844e-03 | 2.774 |
| R-HSA-111996 | Ca-dependent events | 1.701661e-03 | 2.769 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 1.719064e-03 | 2.765 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.375650e-03 | 2.624 |
| R-HSA-1489509 | DAG and IP3 signaling | 2.099356e-03 | 2.678 |
| R-HSA-392517 | Rap1 signalling | 1.895901e-03 | 2.722 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.902767e-03 | 2.721 |
| R-HSA-9833482 | PKR-mediated signaling | 2.040094e-03 | 2.690 |
| R-HSA-449147 | Signaling by Interleukins | 2.223196e-03 | 2.653 |
| R-HSA-437239 | Recycling pathway of L1 | 2.397534e-03 | 2.620 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.491050e-03 | 2.604 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 2.641168e-03 | 2.578 |
| R-HSA-913531 | Interferon Signaling | 2.647575e-03 | 2.577 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 3.016360e-03 | 2.521 |
| R-HSA-9663891 | Selective autophagy | 3.091148e-03 | 2.510 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.225434e-03 | 2.491 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.515199e-03 | 2.454 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.544907e-03 | 2.450 |
| R-HSA-391251 | Protein folding | 3.820152e-03 | 2.418 |
| R-HSA-212436 | Generic Transcription Pathway | 3.865624e-03 | 2.413 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 5.012803e-03 | 2.300 |
| R-HSA-983189 | Kinesins | 5.071155e-03 | 2.295 |
| R-HSA-112043 | PLC beta mediated events | 5.335176e-03 | 2.273 |
| R-HSA-5617833 | Cilium Assembly | 5.352803e-03 | 2.271 |
| R-HSA-180024 | DARPP-32 events | 5.428783e-03 | 2.265 |
| R-HSA-70171 | Glycolysis | 5.430226e-03 | 2.265 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 5.608242e-03 | 2.251 |
| R-HSA-68877 | Mitotic Prometaphase | 5.770923e-03 | 2.239 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 5.890487e-03 | 2.230 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 5.890487e-03 | 2.230 |
| R-HSA-162582 | Signal Transduction | 5.906673e-03 | 2.229 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.793616e-03 | 2.168 |
| R-HSA-112040 | G-protein mediated events | 7.113884e-03 | 2.148 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 7.296677e-03 | 2.137 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.725009e-03 | 2.112 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 7.815798e-03 | 2.107 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 7.815798e-03 | 2.107 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 8.041881e-03 | 2.095 |
| R-HSA-190861 | Gap junction assembly | 8.356193e-03 | 2.078 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 8.494375e-03 | 2.071 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.835696e-03 | 2.054 |
| R-HSA-9832991 | Formation of the posterior neural plate | 8.882890e-03 | 2.051 |
| R-HSA-597592 | Post-translational protein modification | 9.128595e-03 | 2.040 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 9.245926e-03 | 2.034 |
| R-HSA-163560 | Triglyceride catabolism | 9.501540e-03 | 2.022 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 9.990682e-03 | 2.000 |
| R-HSA-380287 | Centrosome maturation | 1.003955e-02 | 1.998 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 1.013105e-02 | 1.994 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 1.013105e-02 | 1.994 |
| R-HSA-1433559 | Regulation of KIT signaling | 1.430711e-02 | 1.844 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.041646e-02 | 1.982 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 1.415374e-02 | 1.849 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.196345e-02 | 1.922 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 1.420392e-02 | 1.848 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.346508e-02 | 1.871 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.346508e-02 | 1.871 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.346508e-02 | 1.871 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 1.221325e-02 | 1.913 |
| R-HSA-392499 | Metabolism of proteins | 1.535389e-02 | 1.814 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.466761e-02 | 1.834 |
| R-HSA-194138 | Signaling by VEGF | 1.379754e-02 | 1.860 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.346508e-02 | 1.871 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.179350e-02 | 1.928 |
| R-HSA-70326 | Glucose metabolism | 1.062136e-02 | 1.974 |
| R-HSA-422475 | Axon guidance | 1.190077e-02 | 1.924 |
| R-HSA-190828 | Gap junction trafficking | 1.574954e-02 | 1.803 |
| R-HSA-8876725 | Protein methylation | 1.583788e-02 | 1.800 |
| R-HSA-9823739 | Formation of the anterior neural plate | 1.583788e-02 | 1.800 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 1.583788e-02 | 1.800 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.627954e-02 | 1.788 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 1.655647e-02 | 1.781 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 1.655647e-02 | 1.781 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.799856e-02 | 1.745 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.823883e-02 | 1.739 |
| R-HSA-9675108 | Nervous system development | 1.861603e-02 | 1.730 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 1.909857e-02 | 1.719 |
| R-HSA-5620924 | Intraflagellar transport | 1.911437e-02 | 1.719 |
| R-HSA-9634597 | GPER1 signaling | 1.911437e-02 | 1.719 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 1.982658e-02 | 1.703 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.001284e-02 | 1.699 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.001284e-02 | 1.699 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.001284e-02 | 1.699 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 2.001284e-02 | 1.699 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 2.082560e-02 | 1.681 |
| R-HSA-9827857 | Specification of primordial germ cells | 2.082560e-02 | 1.681 |
| R-HSA-1632852 | Macroautophagy | 2.194487e-02 | 1.659 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.274728e-02 | 1.643 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 2.312007e-02 | 1.636 |
| R-HSA-422356 | Regulation of insulin secretion | 2.452510e-02 | 1.610 |
| R-HSA-72649 | Translation initiation complex formation | 2.484993e-02 | 1.605 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.588628e-02 | 1.587 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.637638e-02 | 1.579 |
| R-HSA-9823730 | Formation of definitive endoderm | 2.637638e-02 | 1.579 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.694558e-02 | 1.570 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 2.820169e-02 | 1.550 |
| R-HSA-418594 | G alpha (i) signalling events | 2.897294e-02 | 1.538 |
| R-HSA-111885 | Opioid Signalling | 2.904538e-02 | 1.537 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 2.904538e-02 | 1.537 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.913287e-02 | 1.536 |
| R-HSA-2206305 | MPS IIID - Sanfilippo syndrome D | 2.955175e-02 | 1.529 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.996923e-02 | 1.523 |
| R-HSA-8979227 | Triglyceride metabolism | 3.026078e-02 | 1.519 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.037126e-02 | 1.518 |
| R-HSA-9612973 | Autophagy | 3.138429e-02 | 1.503 |
| R-HSA-68882 | Mitotic Anaphase | 3.217350e-02 | 1.493 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.245301e-02 | 1.489 |
| R-HSA-189200 | Cellular hexose transport | 3.245301e-02 | 1.489 |
| R-HSA-445717 | Aquaporin-mediated transport | 3.258491e-02 | 1.487 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.273920e-02 | 1.485 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.298892e-02 | 1.482 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.458922e-02 | 1.461 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.499969e-02 | 1.456 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.499969e-02 | 1.456 |
| R-HSA-1643685 | Disease | 3.558636e-02 | 1.449 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 3.677862e-02 | 1.434 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 3.853989e-02 | 1.414 |
| R-HSA-74160 | Gene expression (Transcription) | 3.894357e-02 | 1.410 |
| R-HSA-420029 | Tight junction interactions | 3.901997e-02 | 1.409 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.901997e-02 | 1.409 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 4.131201e-02 | 1.384 |
| R-HSA-909733 | Interferon alpha/beta signaling | 4.140313e-02 | 1.383 |
| R-HSA-373760 | L1CAM interactions | 4.238370e-02 | 1.373 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 4.876910e-02 | 1.312 |
| R-HSA-5683329 | Defective ABCD4 causes MAHCJ | 4.876910e-02 | 1.312 |
| R-HSA-2132295 | MHC class II antigen presentation | 4.961349e-02 | 1.304 |
| R-HSA-168249 | Innate Immune System | 4.984403e-02 | 1.302 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 5.096314e-02 | 1.293 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.582509e-02 | 1.253 |
| R-HSA-375276 | Peptide ligand-binding receptors | 5.605713e-02 | 1.251 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.606215e-02 | 1.251 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 5.606215e-02 | 1.251 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 6.760821e-02 | 1.170 |
| R-HSA-114516 | Disinhibition of SNARE formation | 9.517383e-02 | 1.021 |
| R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.130994e-01 | 0.947 |
| R-HSA-192823 | Viral mRNA Translation | 1.070876e-01 | 0.970 |
| R-HSA-1433557 | Signaling by SCF-KIT | 9.298388e-02 | 1.032 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 6.402729e-02 | 1.194 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.009368e-01 | 0.996 |
| R-HSA-165158 | Activation of AKT2 | 6.760821e-02 | 1.170 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 7.688824e-02 | 1.114 |
| R-HSA-3371511 | HSF1 activation | 6.953593e-02 | 1.158 |
| R-HSA-390696 | Adrenoceptors | 1.041812e-01 | 0.982 |
| R-HSA-2172127 | DAP12 interactions | 9.605812e-02 | 1.017 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 6.402729e-02 | 1.194 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.022922e-01 | 0.990 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.480793e-02 | 1.072 |
| R-HSA-72312 | rRNA processing | 1.098620e-01 | 0.959 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 8.394287e-02 | 1.076 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 9.517383e-02 | 1.021 |
| R-HSA-444257 | RSK activation | 1.041812e-01 | 0.982 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.225918e-02 | 1.206 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.130994e-01 | 0.947 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 1.022922e-01 | 0.990 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 9.296741e-02 | 1.032 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.004433e-02 | 1.155 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.130994e-01 | 0.947 |
| R-HSA-163685 | Integration of energy metabolism | 6.851861e-02 | 1.164 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 1.022922e-01 | 0.990 |
| R-HSA-70268 | Pyruvate metabolism | 7.251148e-02 | 1.140 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.045422e-01 | 0.981 |
| R-HSA-877300 | Interferon gamma signaling | 1.028110e-01 | 0.988 |
| R-HSA-9694548 | Maturation of spike protein | 8.394287e-02 | 1.076 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 9.605812e-02 | 1.017 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.049031e-01 | 0.979 |
| R-HSA-9614085 | FOXO-mediated transcription | 9.891923e-02 | 1.005 |
| R-HSA-9758941 | Gastrulation | 8.769221e-02 | 1.057 |
| R-HSA-112316 | Neuronal System | 5.818007e-02 | 1.235 |
| R-HSA-201556 | Signaling by ALK | 7.807613e-02 | 1.107 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.158300e-01 | 0.936 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.908413e-02 | 1.229 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.155103e-01 | 0.937 |
| R-HSA-109582 | Hemostasis | 1.098713e-01 | 0.959 |
| R-HSA-9682385 | FLT3 signaling in disease | 6.953593e-02 | 1.158 |
| R-HSA-9679506 | SARS-CoV Infections | 6.476346e-02 | 1.189 |
| R-HSA-9864848 | Complex IV assembly | 1.183367e-01 | 0.927 |
| R-HSA-2514856 | The phototransduction cascade | 1.183367e-01 | 0.927 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.198130e-01 | 0.921 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.198130e-01 | 0.921 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 1.216178e-01 | 0.915 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.219294e-01 | 0.914 |
| R-HSA-173107 | Binding and entry of HIV virion | 1.219294e-01 | 0.914 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.219294e-01 | 0.914 |
| R-HSA-6799990 | Metal sequestration by antimicrobial proteins | 1.219294e-01 | 0.914 |
| R-HSA-5689877 | Josephin domain DUBs | 1.219294e-01 | 0.914 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.219294e-01 | 0.914 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 1.224142e-01 | 0.912 |
| R-HSA-418555 | G alpha (s) signalling events | 1.241160e-01 | 0.906 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 1.241160e-01 | 0.906 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 1.282461e-01 | 0.892 |
| R-HSA-9758890 | Transport of RCbl within the body | 1.306720e-01 | 0.884 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.310233e-01 | 0.883 |
| R-HSA-199991 | Membrane Trafficking | 1.348533e-01 | 0.870 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.349573e-01 | 0.870 |
| R-HSA-5578775 | Ion homeostasis | 1.349573e-01 | 0.870 |
| R-HSA-9758881 | Uptake of dietary cobalamins into enterocytes | 1.393281e-01 | 0.856 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.421753e-01 | 0.847 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.421753e-01 | 0.847 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.468060e-01 | 0.833 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.478986e-01 | 0.830 |
| R-HSA-9005895 | Pervasive developmental disorders | 1.478986e-01 | 0.830 |
| R-HSA-9697154 | Disorders of Nervous System Development | 1.478986e-01 | 0.830 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 1.478986e-01 | 0.830 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.478986e-01 | 0.830 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 1.538435e-01 | 0.813 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.545228e-01 | 0.811 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.563842e-01 | 0.806 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.563842e-01 | 0.806 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.563842e-01 | 0.806 |
| R-HSA-1475029 | Reversible hydration of carbon dioxide | 1.563842e-01 | 0.806 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.620555e-01 | 0.790 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.633677e-01 | 0.787 |
| R-HSA-1234174 | Cellular response to hypoxia | 1.660326e-01 | 0.780 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 1.682270e-01 | 0.774 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 1.731043e-01 | 0.762 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 1.731043e-01 | 0.762 |
| R-HSA-171007 | p38MAPK events | 1.731043e-01 | 0.762 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.731043e-01 | 0.762 |
| R-HSA-388396 | GPCR downstream signalling | 1.738875e-01 | 0.760 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.813405e-01 | 0.742 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.813405e-01 | 0.742 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.813405e-01 | 0.742 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 1.813405e-01 | 0.742 |
| R-HSA-9678110 | Attachment and Entry | 1.813405e-01 | 0.742 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 1.814512e-01 | 0.741 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.873786e-01 | 0.727 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.873786e-01 | 0.727 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.894951e-01 | 0.722 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.894951e-01 | 0.722 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 1.894951e-01 | 0.722 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 1.894951e-01 | 0.722 |
| R-HSA-9675151 | Disorders of Developmental Biology | 1.894951e-01 | 0.722 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.909740e-01 | 0.719 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.975690e-01 | 0.704 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.009057e-01 | 0.697 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.031721e-01 | 0.692 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.055630e-01 | 0.687 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.055630e-01 | 0.687 |
| R-HSA-9694635 | Translation of Structural Proteins | 2.090793e-01 | 0.680 |
| R-HSA-5619084 | ABC transporter disorders | 2.127225e-01 | 0.672 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 2.134778e-01 | 0.671 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.134778e-01 | 0.671 |
| R-HSA-110320 | Translesion Synthesis by POLH | 2.134778e-01 | 0.671 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.134778e-01 | 0.671 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 2.213142e-01 | 0.655 |
| R-HSA-71288 | Creatine metabolism | 2.213142e-01 | 0.655 |
| R-HSA-2022857 | Keratan sulfate degradation | 2.213142e-01 | 0.655 |
| R-HSA-9629569 | Protein hydroxylation | 2.213142e-01 | 0.655 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 2.290730e-01 | 0.640 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 2.290730e-01 | 0.640 |
| R-HSA-167044 | Signalling to RAS | 2.290730e-01 | 0.640 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.290730e-01 | 0.640 |
| R-HSA-196836 | Vitamin C (ascorbate) metabolism | 2.290730e-01 | 0.640 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.310218e-01 | 0.636 |
| R-HSA-9694614 | Attachment and Entry | 2.367551e-01 | 0.626 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 2.367887e-01 | 0.626 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.420518e-01 | 0.616 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.420518e-01 | 0.616 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.420518e-01 | 0.616 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.457342e-01 | 0.610 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 2.502395e-01 | 0.602 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 2.518916e-01 | 0.599 |
| R-HSA-3000170 | Syndecan interactions | 2.518916e-01 | 0.599 |
| R-HSA-156902 | Peptide chain elongation | 2.531052e-01 | 0.597 |
| R-HSA-1236974 | ER-Phagosome pathway | 2.567930e-01 | 0.590 |
| R-HSA-429947 | Deadenylation of mRNA | 2.593476e-01 | 0.586 |
| R-HSA-372790 | Signaling by GPCR | 2.640442e-01 | 0.578 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 2.641712e-01 | 0.578 |
| R-HSA-3214842 | HDMs demethylate histones | 2.667298e-01 | 0.574 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 2.667298e-01 | 0.574 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 2.667298e-01 | 0.574 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.678608e-01 | 0.572 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.678608e-01 | 0.572 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.715503e-01 | 0.566 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.715503e-01 | 0.566 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.789275e-01 | 0.555 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.812754e-01 | 0.551 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.812754e-01 | 0.551 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 2.826144e-01 | 0.549 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.862999e-01 | 0.543 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.862999e-01 | 0.543 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.884404e-01 | 0.540 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.936649e-01 | 0.532 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 2.944844e-01 | 0.531 |
| R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 2.955343e-01 | 0.529 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 2.955343e-01 | 0.529 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 3.014511e-01 | 0.521 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 3.014511e-01 | 0.521 |
| R-HSA-2424491 | DAP12 signaling | 3.025580e-01 | 0.519 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 3.025580e-01 | 0.519 |
| R-HSA-2206281 | Mucopolysaccharidoses | 3.025580e-01 | 0.519 |
| R-HSA-2408557 | Selenocysteine synthesis | 3.083623e-01 | 0.511 |
| R-HSA-399719 | Trafficking of AMPA receptors | 3.095120e-01 | 0.509 |
| R-HSA-5694530 | Cargo concentration in the ER | 3.095120e-01 | 0.509 |
| R-HSA-186763 | Downstream signal transduction | 3.095120e-01 | 0.509 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.163972e-01 | 0.500 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.163972e-01 | 0.500 |
| R-HSA-5653656 | Vesicle-mediated transport | 3.172808e-01 | 0.499 |
| R-HSA-168255 | Influenza Infection | 3.177728e-01 | 0.498 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.193474e-01 | 0.496 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.193474e-01 | 0.496 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 3.232141e-01 | 0.491 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 3.232141e-01 | 0.491 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.232141e-01 | 0.491 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 3.232141e-01 | 0.491 |
| R-HSA-397795 | G-protein beta:gamma signalling | 3.232141e-01 | 0.491 |
| R-HSA-354192 | Integrin signaling | 3.232141e-01 | 0.491 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.232141e-01 | 0.491 |
| R-HSA-390522 | Striated Muscle Contraction | 3.299634e-01 | 0.482 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 3.299634e-01 | 0.482 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.339290e-01 | 0.476 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.339290e-01 | 0.476 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.339290e-01 | 0.476 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 3.366459e-01 | 0.473 |
| R-HSA-5205647 | Mitophagy | 3.366459e-01 | 0.473 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 3.375610e-01 | 0.472 |
| R-HSA-187687 | Signalling to ERKs | 3.432621e-01 | 0.464 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.432621e-01 | 0.464 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 3.498128e-01 | 0.456 |
| R-HSA-114604 | GPVI-mediated activation cascade | 3.498128e-01 | 0.456 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.498128e-01 | 0.456 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.520281e-01 | 0.453 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.520281e-01 | 0.453 |
| R-HSA-8953854 | Metabolism of RNA | 3.529969e-01 | 0.452 |
| R-HSA-2142789 | Ubiquinol biosynthesis | 3.562985e-01 | 0.448 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 3.562985e-01 | 0.448 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 3.585855e-01 | 0.445 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 3.627199e-01 | 0.440 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 3.663866e-01 | 0.436 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 3.690776e-01 | 0.433 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.690776e-01 | 0.433 |
| R-HSA-9648002 | RAS processing | 3.690776e-01 | 0.433 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.690776e-01 | 0.433 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.690776e-01 | 0.433 |
| R-HSA-3371568 | Attenuation phase | 3.753723e-01 | 0.426 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 3.753723e-01 | 0.426 |
| R-HSA-8982491 | Glycogen metabolism | 3.753723e-01 | 0.426 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 3.816046e-01 | 0.418 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 3.816046e-01 | 0.418 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.816046e-01 | 0.418 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 3.816046e-01 | 0.418 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.816046e-01 | 0.418 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 3.816046e-01 | 0.418 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.841612e-01 | 0.415 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.865266e-01 | 0.413 |
| R-HSA-72172 | mRNA Splicing | 3.883257e-01 | 0.411 |
| R-HSA-3371556 | Cellular response to heat stress | 3.912120e-01 | 0.408 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 3.938844e-01 | 0.405 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 3.999331e-01 | 0.398 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 4.059218e-01 | 0.392 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.059218e-01 | 0.392 |
| R-HSA-69236 | G1 Phase | 4.059218e-01 | 0.392 |
| R-HSA-375280 | Amine ligand-binding receptors | 4.059218e-01 | 0.392 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.059218e-01 | 0.392 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.059218e-01 | 0.392 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 4.118511e-01 | 0.385 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 4.118511e-01 | 0.385 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 4.124185e-01 | 0.385 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 4.177216e-01 | 0.379 |
| R-HSA-75153 | Apoptotic execution phase | 4.177216e-01 | 0.379 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 4.235339e-01 | 0.373 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.235339e-01 | 0.373 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.292885e-01 | 0.367 |
| R-HSA-5576891 | Cardiac conduction | 4.327192e-01 | 0.364 |
| R-HSA-8951664 | Neddylation | 4.335887e-01 | 0.363 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 4.349860e-01 | 0.362 |
| R-HSA-73893 | DNA Damage Bypass | 4.349860e-01 | 0.362 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.349860e-01 | 0.362 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 4.394930e-01 | 0.357 |
| R-HSA-109704 | PI3K Cascade | 4.406270e-01 | 0.356 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 4.406270e-01 | 0.356 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 4.462120e-01 | 0.350 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.462120e-01 | 0.350 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 4.517416e-01 | 0.345 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 4.544795e-01 | 0.342 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.555433e-01 | 0.341 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 4.572163e-01 | 0.340 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.572163e-01 | 0.340 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 4.572163e-01 | 0.340 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.626367e-01 | 0.335 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.628494e-01 | 0.335 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.680033e-01 | 0.330 |
| R-HSA-418597 | G alpha (z) signalling events | 4.680033e-01 | 0.330 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.733166e-01 | 0.325 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.733166e-01 | 0.325 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.759400e-01 | 0.322 |
| R-HSA-112399 | IRS-mediated signalling | 4.785772e-01 | 0.320 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.785772e-01 | 0.320 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 4.791826e-01 | 0.319 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.837856e-01 | 0.315 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.889422e-01 | 0.311 |
| R-HSA-2187338 | Visual phototransduction | 4.920306e-01 | 0.308 |
| R-HSA-8873719 | RAB geranylgeranylation | 4.940477e-01 | 0.306 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.940477e-01 | 0.306 |
| R-HSA-351202 | Metabolism of polyamines | 4.940477e-01 | 0.306 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 4.940477e-01 | 0.306 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.940477e-01 | 0.306 |
| R-HSA-69242 | S Phase | 4.952116e-01 | 0.305 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.991025e-01 | 0.302 |
| R-HSA-9679191 | Potential therapeutics for SARS | 5.015359e-01 | 0.300 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 5.015359e-01 | 0.300 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 5.041070e-01 | 0.297 |
| R-HSA-186797 | Signaling by PDGF | 5.041070e-01 | 0.297 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.078094e-01 | 0.294 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 5.078094e-01 | 0.294 |
| R-HSA-2428924 | IGF1R signaling cascade | 5.139676e-01 | 0.289 |
| R-HSA-74751 | Insulin receptor signalling cascade | 5.139676e-01 | 0.289 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 5.188246e-01 | 0.285 |
| R-HSA-9711097 | Cellular response to starvation | 5.263212e-01 | 0.279 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.331079e-01 | 0.273 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.392809e-01 | 0.268 |
| R-HSA-204005 | COPII-mediated vesicle transport | 5.423953e-01 | 0.266 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.423953e-01 | 0.266 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.423953e-01 | 0.266 |
| R-HSA-2408522 | Selenoamino acid metabolism | 5.443614e-01 | 0.264 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.469699e-01 | 0.262 |
| R-HSA-8978934 | Metabolism of cofactors | 5.469699e-01 | 0.262 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.514990e-01 | 0.258 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.514990e-01 | 0.258 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 5.559832e-01 | 0.255 |
| R-HSA-4086398 | Ca2+ pathway | 5.559832e-01 | 0.255 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 5.559832e-01 | 0.255 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.648182e-01 | 0.248 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.648182e-01 | 0.248 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.650876e-01 | 0.248 |
| R-HSA-500792 | GPCR ligand binding | 5.734246e-01 | 0.242 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.765263e-01 | 0.239 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.767163e-01 | 0.239 |
| R-HSA-4086400 | PCP/CE pathway | 5.777442e-01 | 0.238 |
| R-HSA-216083 | Integrin cell surface interactions | 5.777442e-01 | 0.238 |
| R-HSA-9658195 | Leishmania infection | 5.810495e-01 | 0.236 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.810495e-01 | 0.236 |
| R-HSA-9659379 | Sensory processing of sound | 5.819675e-01 | 0.235 |
| R-HSA-611105 | Respiratory electron transport | 5.873521e-01 | 0.231 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.064402e-01 | 0.217 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.103782e-01 | 0.214 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 6.142770e-01 | 0.212 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 6.238202e-01 | 0.205 |
| R-HSA-202424 | Downstream TCR signaling | 6.294885e-01 | 0.201 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.405045e-01 | 0.193 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.476670e-01 | 0.189 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 6.511949e-01 | 0.186 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 6.546877e-01 | 0.184 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 6.581457e-01 | 0.182 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 6.581457e-01 | 0.182 |
| R-HSA-72766 | Translation | 6.611504e-01 | 0.180 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 6.615693e-01 | 0.179 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.649589e-01 | 0.177 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.716371e-01 | 0.173 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.749264e-01 | 0.171 |
| R-HSA-397014 | Muscle contraction | 6.758154e-01 | 0.170 |
| R-HSA-9833110 | RSV-host interactions | 6.877594e-01 | 0.163 |
| R-HSA-69239 | Synthesis of DNA | 6.970527e-01 | 0.157 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.000889e-01 | 0.155 |
| R-HSA-202403 | TCR signaling | 7.060709e-01 | 0.151 |
| R-HSA-6803157 | Antimicrobial peptides | 7.090173e-01 | 0.149 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.150124e-01 | 0.146 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.205123e-01 | 0.142 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.315559e-01 | 0.136 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 7.409032e-01 | 0.130 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.473133e-01 | 0.126 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 7.483294e-01 | 0.126 |
| R-HSA-69206 | G1/S Transition | 7.548437e-01 | 0.122 |
| R-HSA-114608 | Platelet degranulation | 7.597397e-01 | 0.119 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 7.621511e-01 | 0.118 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.669020e-01 | 0.115 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 7.849809e-01 | 0.105 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.871405e-01 | 0.104 |
| R-HSA-6807070 | PTEN Regulation | 7.913951e-01 | 0.102 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.036586e-01 | 0.095 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 8.065454e-01 | 0.093 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.075851e-01 | 0.093 |
| R-HSA-166520 | Signaling by NTRKs | 8.114335e-01 | 0.091 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.166529e-01 | 0.088 |
| R-HSA-2142753 | Arachidonate metabolism | 8.189023e-01 | 0.087 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.262885e-01 | 0.083 |
| R-HSA-162587 | HIV Life Cycle | 8.278262e-01 | 0.082 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.329693e-01 | 0.079 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.329693e-01 | 0.079 |
| R-HSA-109581 | Apoptosis | 8.363129e-01 | 0.078 |
| R-HSA-72306 | tRNA processing | 8.505547e-01 | 0.070 |
| R-HSA-1474244 | Extracellular matrix organization | 8.679815e-01 | 0.061 |
| R-HSA-382551 | Transport of small molecules | 8.789658e-01 | 0.056 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 8.815994e-01 | 0.055 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 8.852222e-01 | 0.053 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 8.930109e-01 | 0.049 |
| R-HSA-5357801 | Programmed Cell Death | 8.962162e-01 | 0.048 |
| R-HSA-162906 | HIV Infection | 9.169802e-01 | 0.038 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.233488e-01 | 0.035 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.249984e-01 | 0.034 |
| R-HSA-8978868 | Fatty acid metabolism | 9.294499e-01 | 0.032 |
| R-HSA-5668914 | Diseases of metabolism | 9.403091e-01 | 0.027 |
| R-HSA-416476 | G alpha (q) signalling events | 9.430059e-01 | 0.025 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.505779e-01 | 0.022 |
| R-HSA-211859 | Biological oxidations | 9.960458e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.994736e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.996524e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.997800e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.837 | 0.274 | 2 | 0.686 |
CDC7 |
0.835 | 0.209 | 1 | 0.881 |
COT |
0.834 | 0.085 | 2 | 0.748 |
NDR2 |
0.829 | 0.096 | -3 | 0.817 |
MOS |
0.829 | 0.210 | 1 | 0.877 |
PIM3 |
0.828 | 0.105 | -3 | 0.807 |
CLK3 |
0.826 | 0.137 | 1 | 0.748 |
PRKD1 |
0.825 | 0.115 | -3 | 0.759 |
CAMK2G |
0.825 | 0.072 | 2 | 0.757 |
IKKB |
0.824 | -0.006 | -2 | 0.748 |
CAMK2B |
0.821 | 0.158 | 2 | 0.757 |
PRPK |
0.821 | -0.022 | -1 | 0.749 |
GRK6 |
0.821 | 0.138 | 1 | 0.823 |
MAPKAPK2 |
0.821 | 0.117 | -3 | 0.707 |
RSK2 |
0.820 | 0.089 | -3 | 0.730 |
IKKA |
0.820 | 0.079 | -2 | 0.728 |
PIM1 |
0.820 | 0.124 | -3 | 0.766 |
CAMK1B |
0.820 | 0.053 | -3 | 0.820 |
GCN2 |
0.819 | -0.081 | 2 | 0.725 |
RAF1 |
0.819 | -0.028 | 1 | 0.808 |
DSTYK |
0.819 | 0.015 | 2 | 0.772 |
GRK1 |
0.819 | 0.111 | -2 | 0.760 |
PRKD2 |
0.818 | 0.089 | -3 | 0.719 |
BMPR1B |
0.817 | 0.224 | 1 | 0.806 |
PDHK4 |
0.817 | -0.123 | 1 | 0.796 |
GRK5 |
0.816 | 0.035 | -3 | 0.825 |
LATS2 |
0.816 | 0.046 | -5 | 0.685 |
NDR1 |
0.815 | 0.033 | -3 | 0.813 |
CAMK2D |
0.815 | 0.060 | -3 | 0.786 |
MTOR |
0.814 | -0.088 | 1 | 0.698 |
BMPR2 |
0.814 | -0.023 | -2 | 0.860 |
MST4 |
0.814 | 0.069 | 2 | 0.757 |
PDHK1 |
0.814 | -0.062 | 1 | 0.799 |
TBK1 |
0.814 | -0.089 | 1 | 0.712 |
SKMLCK |
0.813 | 0.059 | -2 | 0.896 |
CAMK2A |
0.812 | 0.110 | 2 | 0.743 |
ATR |
0.812 | -0.011 | 1 | 0.780 |
ULK2 |
0.812 | -0.097 | 2 | 0.687 |
PKN3 |
0.812 | 0.016 | -3 | 0.784 |
BCKDK |
0.812 | -0.050 | -1 | 0.761 |
GRK4 |
0.811 | 0.015 | -2 | 0.790 |
RSK3 |
0.811 | 0.048 | -3 | 0.727 |
MAPKAPK3 |
0.811 | 0.042 | -3 | 0.744 |
IKKE |
0.811 | -0.094 | 1 | 0.709 |
P70S6KB |
0.810 | 0.061 | -3 | 0.766 |
TGFBR1 |
0.810 | 0.139 | -2 | 0.791 |
PKACG |
0.810 | 0.050 | -2 | 0.786 |
WNK1 |
0.810 | 0.013 | -2 | 0.902 |
P90RSK |
0.809 | 0.027 | -3 | 0.736 |
ALK2 |
0.809 | 0.208 | -2 | 0.789 |
CAMLCK |
0.809 | 0.036 | -2 | 0.874 |
MARK4 |
0.808 | 0.001 | 4 | 0.747 |
AURC |
0.808 | 0.104 | -2 | 0.707 |
NIK |
0.808 | -0.021 | -3 | 0.843 |
LATS1 |
0.807 | 0.113 | -3 | 0.828 |
PAK1 |
0.807 | 0.055 | -2 | 0.823 |
NEK6 |
0.807 | -0.035 | -2 | 0.838 |
PKN2 |
0.807 | 0.011 | -3 | 0.811 |
ATM |
0.807 | 0.044 | 1 | 0.743 |
CDKL1 |
0.806 | -0.009 | -3 | 0.756 |
BMPR1A |
0.806 | 0.230 | 1 | 0.815 |
PRKX |
0.806 | 0.129 | -3 | 0.688 |
PKCD |
0.805 | 0.034 | 2 | 0.660 |
PKACB |
0.805 | 0.104 | -2 | 0.729 |
CHAK2 |
0.805 | -0.053 | -1 | 0.733 |
AMPKA1 |
0.805 | 0.002 | -3 | 0.819 |
DAPK2 |
0.805 | 0.020 | -3 | 0.821 |
NUAK2 |
0.805 | 0.002 | -3 | 0.806 |
GRK7 |
0.805 | 0.116 | 1 | 0.734 |
TSSK2 |
0.805 | 0.040 | -5 | 0.774 |
CK2A2 |
0.805 | 0.243 | 1 | 0.739 |
RSK4 |
0.804 | 0.078 | -3 | 0.714 |
NEK7 |
0.804 | -0.117 | -3 | 0.799 |
MLK1 |
0.804 | -0.086 | 2 | 0.694 |
RIPK3 |
0.804 | -0.096 | 3 | 0.672 |
TSSK1 |
0.804 | 0.049 | -3 | 0.822 |
MSK2 |
0.804 | 0.027 | -3 | 0.714 |
MSK1 |
0.803 | 0.068 | -3 | 0.726 |
HUNK |
0.803 | -0.112 | 2 | 0.715 |
TGFBR2 |
0.803 | -0.041 | -2 | 0.761 |
ALK4 |
0.803 | 0.068 | -2 | 0.819 |
SRPK1 |
0.802 | 0.020 | -3 | 0.711 |
AURA |
0.802 | 0.090 | -2 | 0.674 |
NLK |
0.802 | -0.104 | 1 | 0.721 |
KIS |
0.801 | -0.022 | 1 | 0.579 |
DLK |
0.801 | -0.094 | 1 | 0.784 |
ULK1 |
0.800 | -0.152 | -3 | 0.762 |
WNK3 |
0.799 | -0.167 | 1 | 0.764 |
ACVR2B |
0.799 | 0.095 | -2 | 0.761 |
PAK3 |
0.799 | -0.007 | -2 | 0.826 |
NIM1 |
0.799 | -0.050 | 3 | 0.721 |
CAMK4 |
0.799 | -0.042 | -3 | 0.797 |
CDKL5 |
0.799 | -0.014 | -3 | 0.744 |
PRKD3 |
0.798 | 0.029 | -3 | 0.701 |
PLK3 |
0.798 | 0.011 | 2 | 0.699 |
ACVR2A |
0.798 | 0.068 | -2 | 0.746 |
PKR |
0.798 | 0.047 | 1 | 0.786 |
AMPKA2 |
0.798 | -0.009 | -3 | 0.793 |
MNK2 |
0.797 | 0.030 | -2 | 0.837 |
CHK1 |
0.797 | 0.046 | -3 | 0.808 |
AURB |
0.797 | 0.068 | -2 | 0.705 |
ANKRD3 |
0.797 | -0.090 | 1 | 0.806 |
MASTL |
0.797 | -0.222 | -2 | 0.819 |
CLK2 |
0.796 | 0.096 | -3 | 0.728 |
PLK1 |
0.796 | -0.049 | -2 | 0.768 |
ICK |
0.796 | -0.030 | -3 | 0.784 |
TTBK2 |
0.796 | -0.133 | 2 | 0.612 |
NEK9 |
0.796 | -0.139 | 2 | 0.728 |
HIPK4 |
0.796 | -0.031 | 1 | 0.661 |
PAK6 |
0.795 | 0.048 | -2 | 0.751 |
CLK4 |
0.795 | 0.050 | -3 | 0.747 |
ERK5 |
0.795 | -0.117 | 1 | 0.676 |
SGK3 |
0.795 | 0.060 | -3 | 0.747 |
MLK3 |
0.795 | -0.023 | 2 | 0.619 |
RIPK1 |
0.795 | -0.177 | 1 | 0.757 |
SRPK2 |
0.795 | 0.014 | -3 | 0.643 |
TLK2 |
0.794 | -0.009 | 1 | 0.738 |
QSK |
0.793 | -0.011 | 4 | 0.723 |
DNAPK |
0.793 | 0.035 | 1 | 0.647 |
MLK2 |
0.793 | -0.125 | 2 | 0.705 |
SIK |
0.793 | -0.003 | -3 | 0.736 |
PIM2 |
0.793 | 0.060 | -3 | 0.715 |
PAK2 |
0.793 | -0.016 | -2 | 0.806 |
PKCB |
0.792 | 0.000 | 2 | 0.600 |
PKCA |
0.792 | 0.002 | 2 | 0.603 |
CK2A1 |
0.792 | 0.194 | 1 | 0.711 |
MEK1 |
0.792 | -0.111 | 2 | 0.741 |
CLK1 |
0.792 | 0.052 | -3 | 0.715 |
MNK1 |
0.791 | 0.022 | -2 | 0.835 |
YSK4 |
0.791 | -0.075 | 1 | 0.735 |
MELK |
0.791 | -0.035 | -3 | 0.772 |
PKG2 |
0.791 | 0.046 | -2 | 0.724 |
AKT2 |
0.791 | 0.060 | -3 | 0.660 |
MLK4 |
0.790 | -0.041 | 2 | 0.610 |
PKCG |
0.790 | -0.024 | 2 | 0.603 |
MARK3 |
0.790 | -0.001 | 4 | 0.682 |
BRAF |
0.790 | 0.032 | -4 | 0.813 |
NUAK1 |
0.790 | -0.041 | -3 | 0.770 |
IRE1 |
0.789 | -0.105 | 1 | 0.728 |
MYLK4 |
0.789 | 0.003 | -2 | 0.817 |
CDK8 |
0.789 | -0.065 | 1 | 0.553 |
MARK2 |
0.789 | -0.016 | 4 | 0.641 |
NEK2 |
0.789 | -0.078 | 2 | 0.699 |
BRSK1 |
0.789 | -0.032 | -3 | 0.764 |
PKACA |
0.788 | 0.073 | -2 | 0.680 |
PKCH |
0.788 | -0.026 | 2 | 0.599 |
VRK2 |
0.788 | -0.155 | 1 | 0.815 |
QIK |
0.787 | -0.103 | -3 | 0.794 |
DCAMKL1 |
0.787 | 0.012 | -3 | 0.758 |
MAPKAPK5 |
0.786 | -0.065 | -3 | 0.682 |
SRPK3 |
0.786 | -0.025 | -3 | 0.691 |
SMG1 |
0.786 | -0.071 | 1 | 0.733 |
DYRK2 |
0.786 | -0.041 | 1 | 0.569 |
PASK |
0.785 | 0.026 | -3 | 0.814 |
PHKG1 |
0.784 | -0.076 | -3 | 0.796 |
IRE2 |
0.784 | -0.090 | 2 | 0.641 |
CHAK1 |
0.783 | -0.128 | 2 | 0.656 |
MARK1 |
0.783 | -0.043 | 4 | 0.703 |
AKT1 |
0.783 | 0.062 | -3 | 0.683 |
JNK3 |
0.783 | -0.029 | 1 | 0.531 |
P70S6K |
0.782 | 0.012 | -3 | 0.680 |
CDK1 |
0.782 | -0.034 | 1 | 0.500 |
PKCZ |
0.782 | -0.068 | 2 | 0.654 |
GRK2 |
0.782 | -0.070 | -2 | 0.695 |
CDK19 |
0.782 | -0.070 | 1 | 0.513 |
TLK1 |
0.782 | -0.056 | -2 | 0.806 |
CK1E |
0.781 | -0.009 | -3 | 0.582 |
BRSK2 |
0.781 | -0.088 | -3 | 0.784 |
CAMK1D |
0.781 | 0.029 | -3 | 0.676 |
PERK |
0.781 | -0.104 | -2 | 0.787 |
JNK2 |
0.781 | -0.021 | 1 | 0.491 |
CAMK1G |
0.781 | -0.043 | -3 | 0.718 |
GAK |
0.780 | 0.110 | 1 | 0.815 |
PLK2 |
0.780 | 0.051 | -3 | 0.805 |
ZAK |
0.780 | -0.077 | 1 | 0.750 |
DRAK1 |
0.779 | -0.110 | 1 | 0.692 |
CDK5 |
0.779 | -0.041 | 1 | 0.572 |
WNK4 |
0.778 | -0.087 | -2 | 0.892 |
DCAMKL2 |
0.778 | -0.037 | -3 | 0.776 |
MEKK3 |
0.778 | -0.146 | 1 | 0.748 |
MST3 |
0.778 | -0.015 | 2 | 0.708 |
HRI |
0.778 | -0.148 | -2 | 0.815 |
SNRK |
0.778 | -0.176 | 2 | 0.597 |
CDK7 |
0.778 | -0.096 | 1 | 0.554 |
SSTK |
0.778 | -0.009 | 4 | 0.706 |
MEKK1 |
0.778 | -0.127 | 1 | 0.780 |
DAPK3 |
0.777 | 0.060 | -3 | 0.773 |
SMMLCK |
0.777 | -0.013 | -3 | 0.775 |
PLK4 |
0.777 | -0.146 | 2 | 0.568 |
MEKK2 |
0.777 | -0.084 | 2 | 0.697 |
PRP4 |
0.776 | -0.032 | -3 | 0.731 |
TAO3 |
0.776 | -0.043 | 1 | 0.738 |
HIPK2 |
0.776 | -0.015 | 1 | 0.479 |
CK1G1 |
0.775 | -0.036 | -3 | 0.591 |
CDK2 |
0.775 | -0.075 | 1 | 0.589 |
HIPK1 |
0.775 | -0.025 | 1 | 0.592 |
GRK3 |
0.774 | -0.043 | -2 | 0.650 |
P38A |
0.774 | -0.064 | 1 | 0.564 |
PAK5 |
0.774 | -0.002 | -2 | 0.691 |
GSK3B |
0.774 | -0.029 | 4 | 0.387 |
CDK13 |
0.774 | -0.100 | 1 | 0.527 |
PINK1 |
0.774 | -0.166 | 1 | 0.729 |
MEK5 |
0.773 | -0.243 | 2 | 0.716 |
SGK1 |
0.773 | 0.060 | -3 | 0.598 |
PKCT |
0.773 | -0.039 | 2 | 0.606 |
NEK5 |
0.773 | -0.137 | 1 | 0.775 |
GSK3A |
0.773 | -0.005 | 4 | 0.404 |
CDK18 |
0.773 | -0.065 | 1 | 0.482 |
CK1D |
0.773 | -0.010 | -3 | 0.531 |
DYRK4 |
0.772 | -0.031 | 1 | 0.497 |
IRAK4 |
0.772 | -0.117 | 1 | 0.755 |
PHKG2 |
0.772 | -0.063 | -3 | 0.761 |
PAK4 |
0.772 | 0.004 | -2 | 0.695 |
DYRK1A |
0.772 | -0.047 | 1 | 0.614 |
P38G |
0.772 | -0.051 | 1 | 0.416 |
DAPK1 |
0.771 | 0.039 | -3 | 0.757 |
CK1A2 |
0.770 | -0.015 | -3 | 0.532 |
P38B |
0.770 | -0.060 | 1 | 0.496 |
AKT3 |
0.770 | 0.058 | -3 | 0.601 |
MPSK1 |
0.770 | -0.009 | 1 | 0.727 |
TTBK1 |
0.770 | -0.157 | 2 | 0.538 |
IRAK1 |
0.769 | -0.185 | -1 | 0.679 |
CDK3 |
0.768 | -0.029 | 1 | 0.448 |
ERK1 |
0.768 | -0.076 | 1 | 0.485 |
CAMKK1 |
0.768 | -0.151 | -2 | 0.736 |
MRCKA |
0.768 | 0.041 | -3 | 0.743 |
PKCE |
0.768 | 0.007 | 2 | 0.595 |
ROCK2 |
0.768 | 0.064 | -3 | 0.780 |
EEF2K |
0.767 | -0.016 | 3 | 0.766 |
MRCKB |
0.766 | 0.043 | -3 | 0.719 |
TNIK |
0.766 | 0.004 | 3 | 0.779 |
PKCI |
0.766 | -0.053 | 2 | 0.624 |
TAO2 |
0.766 | -0.104 | 2 | 0.724 |
CDK12 |
0.766 | -0.104 | 1 | 0.496 |
CDK9 |
0.766 | -0.113 | 1 | 0.534 |
MST2 |
0.765 | -0.065 | 1 | 0.765 |
ERK2 |
0.765 | -0.113 | 1 | 0.530 |
HIPK3 |
0.765 | -0.066 | 1 | 0.589 |
TAK1 |
0.765 | -0.069 | 1 | 0.766 |
DYRK1B |
0.765 | -0.056 | 1 | 0.532 |
CDK17 |
0.765 | -0.083 | 1 | 0.425 |
LKB1 |
0.764 | -0.121 | -3 | 0.792 |
GCK |
0.764 | -0.063 | 1 | 0.725 |
DYRK3 |
0.764 | -0.037 | 1 | 0.597 |
NEK11 |
0.764 | -0.176 | 1 | 0.729 |
MINK |
0.764 | -0.041 | 1 | 0.737 |
CDK16 |
0.764 | -0.036 | 1 | 0.450 |
HGK |
0.763 | -0.050 | 3 | 0.777 |
PDK1 |
0.763 | -0.120 | 1 | 0.736 |
CAMKK2 |
0.763 | -0.134 | -2 | 0.737 |
NEK8 |
0.763 | -0.188 | 2 | 0.698 |
SBK |
0.763 | 0.030 | -3 | 0.535 |
P38D |
0.762 | -0.047 | 1 | 0.452 |
CAMK1A |
0.761 | 0.000 | -3 | 0.626 |
CHK2 |
0.761 | -0.019 | -3 | 0.609 |
MEKK6 |
0.760 | -0.100 | 1 | 0.735 |
CDK14 |
0.760 | -0.082 | 1 | 0.529 |
PKN1 |
0.760 | -0.039 | -3 | 0.689 |
JNK1 |
0.760 | -0.052 | 1 | 0.484 |
CDK10 |
0.759 | -0.050 | 1 | 0.512 |
MAP3K15 |
0.759 | -0.111 | 1 | 0.723 |
NEK4 |
0.759 | -0.171 | 1 | 0.742 |
LOK |
0.758 | -0.079 | -2 | 0.784 |
HPK1 |
0.758 | -0.079 | 1 | 0.712 |
VRK1 |
0.758 | -0.130 | 2 | 0.713 |
ERK7 |
0.757 | -0.047 | 2 | 0.456 |
DMPK1 |
0.757 | 0.067 | -3 | 0.728 |
KHS1 |
0.757 | -0.030 | 1 | 0.720 |
LRRK2 |
0.757 | -0.170 | 2 | 0.737 |
PBK |
0.756 | 0.030 | 1 | 0.753 |
MST1 |
0.755 | -0.119 | 1 | 0.742 |
PDHK3_TYR |
0.755 | 0.172 | 4 | 0.839 |
STK33 |
0.755 | -0.159 | 2 | 0.539 |
ALPHAK3 |
0.754 | 0.077 | -1 | 0.689 |
YSK1 |
0.754 | -0.065 | 2 | 0.697 |
KHS2 |
0.754 | -0.030 | 1 | 0.718 |
NEK1 |
0.754 | -0.160 | 1 | 0.756 |
PKG1 |
0.753 | 0.004 | -2 | 0.653 |
CRIK |
0.753 | 0.048 | -3 | 0.668 |
ROCK1 |
0.752 | 0.032 | -3 | 0.742 |
MAK |
0.752 | 0.004 | -2 | 0.730 |
SLK |
0.751 | -0.122 | -2 | 0.718 |
OSR1 |
0.751 | -0.017 | 2 | 0.697 |
MEK2 |
0.751 | -0.216 | 2 | 0.714 |
YANK3 |
0.749 | -0.047 | 2 | 0.360 |
BUB1 |
0.747 | -0.019 | -5 | 0.704 |
RIPK2 |
0.747 | -0.250 | 1 | 0.716 |
TTK |
0.746 | -0.041 | -2 | 0.776 |
CDK6 |
0.746 | -0.092 | 1 | 0.511 |
MAP2K4_TYR |
0.745 | 0.026 | -1 | 0.776 |
PDHK1_TYR |
0.745 | 0.059 | -1 | 0.798 |
MAP2K6_TYR |
0.745 | 0.027 | -1 | 0.771 |
NEK3 |
0.745 | -0.145 | 1 | 0.717 |
EPHA6 |
0.744 | 0.116 | -1 | 0.803 |
MOK |
0.744 | -0.035 | 1 | 0.594 |
BIKE |
0.744 | 0.059 | 1 | 0.723 |
BMPR2_TYR |
0.742 | 0.006 | -1 | 0.779 |
PDHK4_TYR |
0.742 | -0.012 | 2 | 0.777 |
TESK1_TYR |
0.742 | -0.070 | 3 | 0.830 |
CDK4 |
0.742 | -0.104 | 1 | 0.486 |
HASPIN |
0.741 | -0.048 | -1 | 0.580 |
ASK1 |
0.741 | -0.109 | 1 | 0.722 |
PKMYT1_TYR |
0.740 | -0.057 | 3 | 0.794 |
EPHB4 |
0.740 | 0.072 | -1 | 0.791 |
MAP2K7_TYR |
0.739 | -0.182 | 2 | 0.763 |
MYO3B |
0.739 | -0.069 | 2 | 0.706 |
MYO3A |
0.738 | -0.066 | 1 | 0.725 |
YES1 |
0.736 | 0.064 | -1 | 0.789 |
EPHA4 |
0.736 | 0.075 | 2 | 0.700 |
FER |
0.735 | 0.028 | 1 | 0.863 |
RET |
0.735 | -0.075 | 1 | 0.757 |
CK1A |
0.735 | -0.053 | -3 | 0.456 |
PINK1_TYR |
0.735 | -0.182 | 1 | 0.781 |
EPHB2 |
0.734 | 0.098 | -1 | 0.791 |
LIMK2_TYR |
0.733 | -0.068 | -3 | 0.835 |
TXK |
0.733 | 0.068 | 1 | 0.827 |
SRMS |
0.732 | 0.041 | 1 | 0.854 |
EPHB3 |
0.731 | 0.049 | -1 | 0.778 |
EPHB1 |
0.731 | 0.026 | 1 | 0.844 |
TAO1 |
0.731 | -0.144 | 1 | 0.682 |
ABL2 |
0.730 | -0.009 | -1 | 0.745 |
BLK |
0.729 | 0.100 | -1 | 0.766 |
LCK |
0.729 | 0.086 | -1 | 0.762 |
STLK3 |
0.729 | -0.149 | 1 | 0.722 |
HCK |
0.729 | 0.021 | -1 | 0.756 |
DDR1 |
0.729 | -0.098 | 4 | 0.748 |
FGR |
0.729 | -0.048 | 1 | 0.808 |
TYK2 |
0.728 | -0.167 | 1 | 0.767 |
ABL1 |
0.727 | -0.019 | -1 | 0.752 |
LIMK1_TYR |
0.726 | -0.199 | 2 | 0.749 |
MST1R |
0.726 | -0.166 | 3 | 0.709 |
FYN |
0.726 | 0.080 | -1 | 0.741 |
INSRR |
0.726 | -0.047 | 3 | 0.663 |
AAK1 |
0.726 | 0.082 | 1 | 0.622 |
TYRO3 |
0.726 | -0.146 | 3 | 0.699 |
ROS1 |
0.725 | -0.127 | 3 | 0.668 |
FGFR2 |
0.725 | -0.078 | 3 | 0.725 |
JAK2 |
0.724 | -0.158 | 1 | 0.758 |
ITK |
0.724 | -0.033 | -1 | 0.724 |
EPHA7 |
0.724 | 0.020 | 2 | 0.692 |
JAK3 |
0.724 | -0.088 | 1 | 0.740 |
CSF1R |
0.723 | -0.135 | 3 | 0.691 |
CK1G3 |
0.721 | -0.042 | -3 | 0.417 |
EPHA5 |
0.721 | 0.052 | 2 | 0.688 |
FLT3 |
0.720 | -0.114 | 3 | 0.689 |
PDGFRB |
0.720 | -0.129 | 3 | 0.702 |
KIT |
0.719 | -0.120 | 3 | 0.701 |
EPHA3 |
0.719 | -0.046 | 2 | 0.673 |
PTK6 |
0.719 | -0.099 | -1 | 0.676 |
TEC |
0.719 | -0.029 | -1 | 0.685 |
MERTK |
0.719 | -0.078 | 3 | 0.687 |
TNK2 |
0.718 | -0.120 | 3 | 0.656 |
AXL |
0.718 | -0.118 | 3 | 0.680 |
LTK |
0.718 | -0.075 | 3 | 0.649 |
KDR |
0.717 | -0.108 | 3 | 0.655 |
NEK10_TYR |
0.716 | -0.126 | 1 | 0.627 |
FGFR1 |
0.716 | -0.125 | 3 | 0.672 |
BMX |
0.716 | -0.061 | -1 | 0.641 |
FLT1 |
0.716 | -0.065 | -1 | 0.783 |
NTRK1 |
0.715 | -0.126 | -1 | 0.762 |
LYN |
0.715 | -0.008 | 3 | 0.627 |
PTK2B |
0.715 | -0.014 | -1 | 0.747 |
SRC |
0.714 | 0.011 | -1 | 0.763 |
TNNI3K_TYR |
0.714 | -0.078 | 1 | 0.772 |
EGFR |
0.714 | -0.022 | 1 | 0.663 |
BTK |
0.714 | -0.145 | -1 | 0.693 |
EPHA8 |
0.714 | -0.028 | -1 | 0.753 |
PTK2 |
0.714 | 0.028 | -1 | 0.750 |
ALK |
0.713 | -0.108 | 3 | 0.619 |
TEK |
0.713 | -0.147 | 3 | 0.646 |
EPHA1 |
0.713 | -0.081 | 3 | 0.646 |
YANK2 |
0.713 | -0.080 | 2 | 0.378 |
SYK |
0.712 | 0.048 | -1 | 0.708 |
FGFR3 |
0.712 | -0.115 | 3 | 0.692 |
FRK |
0.712 | -0.062 | -1 | 0.755 |
ERBB2 |
0.712 | -0.135 | 1 | 0.734 |
TNK1 |
0.712 | -0.158 | 3 | 0.688 |
MET |
0.712 | -0.133 | 3 | 0.682 |
INSR |
0.711 | -0.106 | 3 | 0.633 |
PDGFRA |
0.710 | -0.223 | 3 | 0.700 |
WEE1_TYR |
0.710 | -0.132 | -1 | 0.665 |
JAK1 |
0.709 | -0.145 | 1 | 0.709 |
FLT4 |
0.709 | -0.133 | 3 | 0.677 |
NTRK2 |
0.709 | -0.156 | 3 | 0.665 |
DDR2 |
0.708 | -0.046 | 3 | 0.647 |
MATK |
0.708 | -0.105 | -1 | 0.696 |
NTRK3 |
0.708 | -0.122 | -1 | 0.711 |
FGFR4 |
0.707 | -0.067 | -1 | 0.737 |
CSK |
0.707 | -0.107 | 2 | 0.697 |
EPHA2 |
0.707 | -0.020 | -1 | 0.736 |
CK1G2 |
0.699 | -0.065 | -3 | 0.508 |
ERBB4 |
0.697 | -0.051 | 1 | 0.693 |
IGF1R |
0.697 | -0.108 | 3 | 0.586 |
MUSK |
0.689 | -0.166 | 1 | 0.646 |
FES |
0.684 | -0.128 | -1 | 0.657 |
ZAP70 |
0.676 | -0.079 | -1 | 0.624 |