Motif 1140 (n=148)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0JLT2 | MED19 | S234 | ochoa | Mediator of RNA polymerase II transcription subunit 19 (Lung cancer metastasis-related protein 1) (Mediator complex subunit 19) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| A0JLT2 | MED19 | S235 | ochoa | Mediator of RNA polymerase II transcription subunit 19 (Lung cancer metastasis-related protein 1) (Mediator complex subunit 19) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
| O00168 | FXYD1 | S83 | ochoa|psp | Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1) | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. {ECO:0000250|UniProtKB:O08589, ECO:0000250|UniProtKB:P56513, ECO:0000250|UniProtKB:Q9Z239}. |
| O00483 | NDUFA4 | S72 | ochoa | Cytochrome c oxidase subunit NDUFA4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:22902835). NDUFA4 is required for complex IV maintenance (PubMed:22902835). {ECO:0000269|PubMed:22902835}. |
| O00541 | PES1 | S578 | ochoa | Pescadillo homolog | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}. |
| O14757 | CHEK1 | S468 | ochoa | Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}. |
| O14944 | EREG | S161 | ochoa | Proepiregulin [Cleaved into: Epiregulin (EPR)] | Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). {ECO:0000269|PubMed:9419975, ECO:0000303|PubMed:24631357}. |
| O15355 | PPM1G | S537 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O43709 | BUD23 | Y272 | ochoa | 18S rRNA (guanine-N(7))-methyltransferase (EC 2.1.1.-) (Bud site selection protein 23 homolog) (Metastasis-related methyltransferase 1) (Williams-Beuren syndrome chromosomal region 22 protein) (rRNA methyltransferase and ribosome maturation factor) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). {ECO:0000250, ECO:0000269|PubMed:24086612, ECO:0000269|PubMed:24488492, ECO:0000269|PubMed:25851604}. |
| O60669 | SLC16A7 | S469 | ochoa | Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) | Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067). {ECO:0000269|PubMed:32415067, ECO:0000269|PubMed:9786900}. |
| O75027 | ABCB7 | S743 | ochoa | Iron-sulfur clusters transporter ABCB7, mitochondrial (ATP-binding cassette sub-family B member 7, mitochondrial) (ATP-binding cassette transporter 7) (ABC transporter 7 protein) | Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:10196363, PubMed:17192393, PubMed:33157103). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q61102, ECO:0000250|UniProtKB:Q704E8, ECO:0000269|PubMed:10196363, ECO:0000269|PubMed:17192393, ECO:0000269|PubMed:30765471, ECO:0000269|PubMed:33157103}. |
| O75116 | ROCK2 | S1379 | psp | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| O75436 | VPS26A | S318 | ochoa | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}. |
| O75475 | PSIP1 | S522 | ochoa | PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269|PubMed:15642333}. |
| O75691 | UTP20 | S2777 | ochoa | Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821, ECO:0000269|PubMed:34516797}. |
| O95239 | KIF4A | S1222 | ochoa | Chromosome-associated kinesin KIF4A (Chromokinesin-A) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}. |
| O95297 | MPZL1 | S260 | ochoa | Myelin protein zero-like protein 1 (Protein zero-related) | Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269|PubMed:11751924, ECO:0000269|PubMed:12410637}. |
| P05386 | RPLP1 | S104 | ochoa|psp | Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) | Plays an important role in the elongation step of protein synthesis. |
| P05387 | RPLP2 | S105 | ochoa|psp | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P05549 | TFAP2A | S429 | psp | Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
| P06400 | RB1 | S919 | ochoa | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P06732 | CKM | S372 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
| P09132 | SRP19 | S135 | ochoa | Signal recognition particle 19 kDa protein (SRP19) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity). {ECO:0000250|UniProtKB:J9PAS6}. |
| P11234 | RALB | S198 | psp | Ras-related protein Ral-B (EC 3.6.5.2) | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179). {ECO:0000250|UniProtKB:P36860, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269}. |
| P13612 | ITGA4 | S1023 | ochoa | Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:35802072}. |
| P13612 | ITGA4 | Y1024 | psp | Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:35802072}. |
| P13747 | HLA-E | S349 | ochoa | HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)] | Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides - VMAPRT[V/L][L/V/I/F]L) (PubMed:18083576, PubMed:18339401, PubMed:35705051, PubMed:37264229, PubMed:9754572). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:17179229, PubMed:18083576, PubMed:37264229, PubMed:9486650, PubMed:9754572). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:30134159, PubMed:37264229, PubMed:9754572). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8-positive cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:20195504, PubMed:30087334, PubMed:34228645). Presents HIV gag peptides (immunodominant KAFSPEVIPMF and subdominant KALGPAATL epitopes) predominantly to CD8-positive T cell clones expressing a TRAV17-containing TCR, triggering HLA-E-restricted T cell responses (PubMed:34228645). Presents mycobacterial peptides to HLA-E-restricted CD8-positive T cells eliciting both cytotoxic and immunoregulatory functions (PubMed:20195504, PubMed:35705051). {ECO:0000269|PubMed:12461076, ECO:0000269|PubMed:16474394, ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:18083576, ECO:0000269|PubMed:18339401, ECO:0000269|PubMed:20195504, ECO:0000269|PubMed:30087334, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:34228645, ECO:0000269|PubMed:35705051, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9486650, ECO:0000269|PubMed:9754572}.; FUNCTION: (Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. {ECO:0000269|PubMed:10799855, ECO:0000269|PubMed:23335510}.; FUNCTION: (Microbial infection) May bind HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition. {ECO:0000269|PubMed:15751767}.; FUNCTION: (Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32859121). Binds SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening of antiviral immune surveillance (PubMed:32859121). {ECO:0000269|PubMed:32859121}. |
| P13861 | PRKAR2A | S395 | ochoa | cAMP-dependent protein kinase type II-alpha regulatory subunit | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| P16284 | PECAM1 | S729 | ochoa | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}. |
| P16949 | STMN1 | S139 | ochoa | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17) | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}. |
| P17096 | HMGA1 | S99 | ochoa|psp | High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R) | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| P17509 | HOXB6 | S214 | ochoa | Homeobox protein Hox-B6 (Homeobox protein Hox-2.2) (Homeobox protein Hox-2B) (Homeobox protein Hu-2) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P17661 | DES | S460 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P19525 | EIF2AK2 | S542 | ochoa|psp | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P25025 | CXCR2 | S351 | psp | C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182) | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. {ECO:0000269|PubMed:1891716, ECO:0000269|PubMed:8662698}. |
| P26006 | ITGA3 | S1042 | ochoa|psp | Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.; FUNCTION: (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. {ECO:0000269|PubMed:32487760}. |
| P29692 | EEF1D | S272 | ochoa | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). |
| P33316 | DUT | S243 | ochoa | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) | Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P70583, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:17880943, ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:8805593}. |
| P33981 | TTK | S847 | ochoa|psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P35626 | GRK3 | S679 | ochoa | G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2) | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. {ECO:0000250|UniProtKB:P26819}. |
| P39880 | CUX1 | S1496 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P46776 | RPL27A | S139 | ochoa | Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P49619 | DGKG | S782 | ochoa | Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity). {ECO:0000250|UniProtKB:Q91WG7, ECO:0000269|PubMed:8034597}. |
| P51674 | GPM6A | S270 | ochoa | Neuronal membrane glycoprotein M6-a (M6a) | Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}. |
| P52179 | MYOM1 | S1677 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P55040 | GEM | S287 | ochoa|psp | GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) | Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. |
| P55085 | F2RL1 | S388 | psp | Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2] | Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o)-alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. Probably mediates activation of pro-inflammatory and pro-fibrotic responses in fibroblasts, triggered by coagulation factor Xa (F10) (By similarity). Mediates activation of barrier protective signaling responses in endothelial cells, triggered by coagulation factor Xa (F10) (PubMed:22409427). {ECO:0000250|UniProtKB:P55086, ECO:0000269|PubMed:10086357, ECO:0000269|PubMed:10725339, ECO:0000269|PubMed:11413129, ECO:0000269|PubMed:11441110, ECO:0000269|PubMed:11447194, ECO:0000269|PubMed:11714832, ECO:0000269|PubMed:12832443, ECO:0000269|PubMed:15155775, ECO:0000269|PubMed:16359518, ECO:0000269|PubMed:16410250, ECO:0000269|PubMed:16478888, ECO:0000269|PubMed:16714334, ECO:0000269|PubMed:17404307, ECO:0000269|PubMed:17500066, ECO:0000269|PubMed:18424071, ECO:0000269|PubMed:18453611, ECO:0000269|PubMed:18474671, ECO:0000269|PubMed:18622013, ECO:0000269|PubMed:19494303, ECO:0000269|PubMed:19781631, ECO:0000269|PubMed:19864598, ECO:0000269|PubMed:19865078, ECO:0000269|PubMed:20826780, ECO:0000269|PubMed:21501162, ECO:0000269|PubMed:22409427, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:28445455}. |
| P56856 | CLDN18 | S253 | ochoa | Claudin-18 | Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity). {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A1]: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C.neoformans infection. {ECO:0000250|UniProtKB:P56857}.; FUNCTION: [Isoform A2]: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. {ECO:0000250|UniProtKB:P56857}. |
| P62753 | RPS6 | S240 | ochoa|psp | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P78504 | JAG1 | S1210 | ochoa | Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). {ECO:0000250, ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:20437614, ECO:0000269|PubMed:9462510}. |
| P83731 | RPL24 | S149 | ochoa | Large ribosomal subunit protein eL24 (60S ribosomal protein L24) (60S ribosomal protein L30) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P84098 | RPL19 | T187 | ochoa | Large ribosomal subunit protein eL19 (60S ribosomal protein L19) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P98194 | ATP2C1 | S910 | ochoa | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) | ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:14632183, PubMed:20439740). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:10615129, PubMed:14632183, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}. |
| P98194 | ATP2C1 | S911 | ochoa | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 7.2.2.10) (ATP-dependent Ca(2+) pump PMR1) (Ca(2+)/Mn(2+)-ATPase 2C1) (Secretory pathway Ca(2+)-transporting ATPase type 1) (SPCA1) | ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:12707275, PubMed:16192278, PubMed:20439740, PubMed:21187401, PubMed:30923126). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:14632183, PubMed:20439740). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:10615129, PubMed:14632183, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}. |
| Q00325 | SLC25A3 | S353 | ochoa | Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP) | Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity) (PubMed:17273968, PubMed:29237729). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity) (PubMed:17273968). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity). {ECO:0000250|UniProtKB:P12234, ECO:0000250|UniProtKB:P16036, ECO:0000269|PubMed:17273968, ECO:0000269|PubMed:29237729}. |
| Q01082 | SPTBN1 | S2358 | ochoa | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269|PubMed:34211179}. |
| Q02156 | PRKCE | S729 | ochoa|psp | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:36040231}. |
| Q04771 | ACVR1 | S501 | ochoa | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:20628059, PubMed:22977237). As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed:17911401). Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain (PubMed:25354296). In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal (PubMed:9748228). In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor (PubMed:17911401). Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000250|UniProtKB:P37172, ECO:0000269|PubMed:17911401, ECO:0000269|PubMed:20628059, ECO:0000269|PubMed:22977237, ECO:0000269|PubMed:25354296, ECO:0000269|PubMed:9748228}. |
| Q13426 | XRCC4 | S327 | ochoa|psp | DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)] | [DNA repair protein XRCC4]: DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:16412978, PubMed:17124166, PubMed:17290226, PubMed:22228831, PubMed:25597996, PubMed:25742519, PubMed:25934149, PubMed:26100018, PubMed:26774286, PubMed:8548796). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) (PubMed:15385968, PubMed:20852255, PubMed:26774286, PubMed:27437582). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired (PubMed:21768349, PubMed:21775435, PubMed:22287571, PubMed:26100018, PubMed:27437582, PubMed:28500754). The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other (PubMed:27437582). The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors (PubMed:27437582). Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:19837014, PubMed:9242410). XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity (PubMed:10757784, PubMed:10854421, PubMed:12517771, PubMed:17290226, PubMed:21982441, PubMed:22228831, PubMed:9242410). Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10757784, PubMed:10854421). Promotes displacement of PNKP from processed strand break termini (PubMed:20852255, PubMed:28453785). {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:12517771, ECO:0000269|PubMed:15385968, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:17124166, ECO:0000269|PubMed:17290226, ECO:0000269|PubMed:19837014, ECO:0000269|PubMed:20852255, ECO:0000269|PubMed:21768349, ECO:0000269|PubMed:21775435, ECO:0000269|PubMed:21982441, ECO:0000269|PubMed:22228831, ECO:0000269|PubMed:22287571, ECO:0000269|PubMed:25597996, ECO:0000269|PubMed:25742519, ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:26100018, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:27437582, ECO:0000269|PubMed:28453785, ECO:0000269|PubMed:28500754, ECO:0000269|PubMed:8548796, ECO:0000269|PubMed:9242410}.; FUNCTION: [Protein XRCC4, C-terminus]: Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486). This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486). {ECO:0000269|PubMed:33725486}. |
| Q13427 | PPIG | S744 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13427 | PPIG | S745 | ochoa | Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:20676357}. |
| Q13797 | ITGA9 | S1027 | ochoa | Integrin alpha-9 (Integrin alpha-RLC) | Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072). {ECO:0000250, ECO:0000250|UniProtKB:B8JK39, ECO:0000269|PubMed:35802072}. |
| Q14330 | GPR18 | S322 | ochoa | N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18) | G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems (PubMed:21732409, PubMed:26195725). Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA) (PubMed:16844083, PubMed:24762058, PubMed:26195725, PubMed:27572937). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis. Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis (PubMed:27994074). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (By similarity). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Also participates in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). {ECO:0000250|UniProtKB:Q8K1Z6, ECO:0000269|PubMed:16844083, ECO:0000269|PubMed:21732409, ECO:0000269|PubMed:24762058, ECO:0000269|PubMed:26195725, ECO:0000269|PubMed:27572937, ECO:0000269|PubMed:27994074}. |
| Q15054 | POLD3 | S458 | ochoa|psp | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA (PubMed:10219083, PubMed:10852724, PubMed:11595739, PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906, ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888, ECO:0000269|PubMed:38099988}. |
| Q15311 | RALBP1 | S647 | ochoa | RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) | Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}. |
| Q15392 | DHCR24 | Y507 | psp | Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) | Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:22178193, PubMed:25637936). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:21671375, ECO:0000269|PubMed:22010141, ECO:0000269|PubMed:22178193, ECO:0000269|PubMed:25637936}. |
| Q15629 | TRAM1 | S365 | ochoa | Translocating chain-associated membrane protein 1 (Protein TRAM1) | Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:12475939, PubMed:1315422, PubMed:32013668, PubMed:8616892, PubMed:9506517). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER (PubMed:9506517). May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport (PubMed:32013668). Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane (PubMed:8616892). Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane (PubMed:12475939). Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:20430023). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:1315422, ECO:0000269|PubMed:20430023, ECO:0000269|PubMed:32013668, ECO:0000269|PubMed:8616892, ECO:0000269|PubMed:9506517, ECO:0000303|PubMed:32013668}.; FUNCTION: (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells. {ECO:0000269|PubMed:19121997}. |
| Q15847 | ADIRF | S66 | ochoa | Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2) | Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. {ECO:0000269|PubMed:19444912, ECO:0000269|PubMed:23239344}. |
| Q16612 | NREP | S59 | psp | Neuronal regeneration-related protein (Neuronal protein 3.1) (Protein p311) | May have roles in neural function. Ectopic expression augments motility of gliomas. Also promotes axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. {ECO:0000250, ECO:0000269|PubMed:11358844, ECO:0000269|PubMed:16229809}. |
| Q16666 | IFI16 | S776 | ochoa | Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator) | Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.; FUNCTION: [Isoform IFI16-beta]: Isoform that specifically inhibits the AIM2 inflammasome (PubMed:30104205). Binds double-stranded DNA (dsDNA) in the cytoplasm, impeding its detection by AIM2 (PubMed:30104205). Also prevents the interaction between AIM2 and PYCARD/ASC via its interaction with AIM2, thereby inhibiting assembly of the AIM2 inflammasome (PubMed:30104205). This isoform also weakly induce production of type I interferon-beta (IFNB1) via its interaction with STING1 (PubMed:30104205). {ECO:0000269|PubMed:30104205}. |
| Q2M389 | WASHC4 | S1164 | ochoa | WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP) | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093, ECO:0000303|PubMed:21498477}. |
| Q2VIQ3 | KIF4B | S1224 | ochoa | Chromosome-associated kinesin KIF4B (Chromokinesin-B) | Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (By similarity). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:O95239, ECO:0000250|UniProtKB:P33174}. |
| Q3B726 | POLR1F | S328 | ochoa | DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}. |
| Q3B820 | FAM161A | S650 | ochoa | Protein FAM161A | Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}. |
| Q3ZCQ3 | FAM174B | S151 | ochoa | Membrane protein FAM174B | Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}. |
| Q5TDH0 | DDI2 | S390 | ochoa | Protein DDI1 homolog 2 (EC 3.4.23.-) | Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27528193, PubMed:27676298). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298, ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}. |
| Q5W0B1 | OBI1 | S717 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q658Y4 | FAM91A1 | S829 | ochoa | Protein FAM91A1 | As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}. |
| Q66K14 | TBC1D9B | S1241 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q6DN12 | MCTP2 | S869 | ochoa | Multiple C2 and transmembrane domain-containing protein 2 | Might play a role in the development of cardiac outflow tract. {ECO:0000269|PubMed:23773997}. |
| Q6DN14 | MCTP1 | S989 | ochoa | Multiple C2 and transmembrane domain-containing protein 1 | Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250|UniProtKB:A1ZBD6}. |
| Q6P2C0 | WDR93 | S678 | ochoa | WD repeat-containing protein 93 | None |
| Q6P6C2 | ALKBH5 | S384 | ochoa | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}. |
| Q86WC4 | OSTM1 | S325 | ochoa | Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) | Required for osteoclast and melanocyte maturation and function. {ECO:0000250, ECO:0000269|PubMed:21527911}. |
| Q8IV50 | LYSMD2 | S206 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 2 | None |
| Q8IYK8 | REM2 | S331 | ochoa | GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) | Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}. |
| Q8IYT8 | ULK2 | S1027 | psp | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635, ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}. |
| Q8N9Q2 | SREK1IP1 | S145 | ochoa | Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP) | Possible splicing regulator involved in the control of cellular survival. |
| Q8N9Q2 | SREK1IP1 | T146 | ochoa | Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP) | Possible splicing regulator involved in the control of cellular survival. |
| Q8NC54 | KCT2 | S256 | ochoa | Keratinocyte-associated transmembrane protein 2 | None |
| Q8TCT9 | HM13 | S369 | ochoa | Signal peptide peptidase (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Minor histocompatibility antigen H13) (Presenilin-like protein 3) (Signal peptide peptidase-like 1) | Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm (PubMed:12077416). Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). {ECO:0000250|UniProtKB:Q9D8V0, ECO:0000269|PubMed:11714810, ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:12145199, ECO:0000269|PubMed:14741365, ECO:0000269|PubMed:25239945}. |
| Q8WVC0 | LEO1 | S658 | ochoa | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15791002, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742}. |
| Q92963 | RIT1 | S209 | psp | GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) | Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. {ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}. |
| Q969H6 | POP5 | S154 | ochoa | Ribonuclease P/MRP protein subunit POP5 (hPop5) | Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:11413139, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:11413139, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648}. |
| Q96AT1 | KIAA1143 | S146 | ochoa | Uncharacterized protein KIAA1143 | None |
| Q96B36 | AKT1S1 | S247 | ochoa | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}. |
| Q96D42 | HAVCR1 | Y355 | psp | Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365) | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as a regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (PubMed:17471468). {ECO:0000250|UniProtKB:Q5QNS5, ECO:0000269|PubMed:17471468, ECO:0000269|PubMed:24703780}.; FUNCTION: (Microbial infection) Acts as a receptor for Hepatitis A virus. {ECO:0000269|PubMed:29437974, ECO:0000269|PubMed:9658108}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed:26487564). {ECO:0000269|PubMed:21536871, ECO:0000269|PubMed:26487564}.; FUNCTION: (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921). TIM1 and Dengue virus are co-internalized during virus entry (PubMed:29742433). {ECO:0000269|PubMed:23084921, ECO:0000269|PubMed:29742433}.; FUNCTION: (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. {ECO:0000269|PubMed:32641828}.; FUNCTION: (Microbial infection) Plays a positive role in Chikungunya virus cell entry. {ECO:0000269|PubMed:34359995}. |
| Q96JK2 | DCAF5 | S934 | ochoa | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | Is a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex (CRL4) (PubMed:29691401, PubMed:30442713). The complex CRL4-DCAF5 is involved in the ubiquitination of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 (PubMed:29691401, PubMed:30442713). {ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96N67 | DOCK7 | S2131 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q99661 | KIF2C | S715 | ochoa|psp | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q9BPZ7 | MAPKAP1 | S512 | ochoa | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) | Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15467718, PubMed:16919458, PubMed:16962653, PubMed:17043309, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16919458, PubMed:16962653, PubMed:21806543, PubMed:28264193, PubMed:28968999, PubMed:30837283, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:16962653). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:21806543, PubMed:28264193). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:28264193, PubMed:35926713). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:30837283, PubMed:35926713). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (PubMed:15467718). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (PubMed:15467718). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (PubMed:15988011). Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (PubMed:17054722). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834). {ECO:0000250|UniProtKB:Q8BKH7, ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16919458, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23727834, ECO:0000269|PubMed:28264193, ECO:0000269|PubMed:28968999, ECO:0000269|PubMed:30837283, ECO:0000269|PubMed:34380736, ECO:0000269|PubMed:35522713, ECO:0000269|PubMed:35926713}.; FUNCTION: [Isoform 4]: In contrast to isoform 1, isoform 2 and isoform 6, isoform 4 is not a component of the a mTORC2 complex. {ECO:0000269|PubMed:26263164}. |
| Q9BRV8 | SIKE1 | S198 | ochoa|psp | Suppressor of IKBKE 1 (Suppressor of IKK-epsilon) | Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways (PubMed:16281057). Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:30622739). {ECO:0000269|PubMed:16281057, ECO:0000269|PubMed:30622739}. |
| Q9BTC0 | DIDO1 | S2232 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BU23 | LMF2 | S698 | ochoa | Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153) | Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity). {ECO:0000250}. |
| Q9BVS4 | RIOK2 | S543 | ochoa | Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710). {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402, ECO:0000269|PubMed:21880710}. |
| Q9BX63 | BRIP1 | S1239 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BZS1 | FOXP3 | S422 | psp | Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form] | Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18368049, ECO:0000269|PubMed:21458306, ECO:0000269|PubMed:23169781, ECO:0000269|PubMed:24835996, ECO:0000269|PubMed:30513302, ECO:0000269|PubMed:32644293, ECO:0000303|PubMed:23947341, ECO:0000303|PubMed:24354325, ECO:0000303|PubMed:24722479}. |
| Q9GZN1 | ACTR6 | S388 | ochoa | Actin-related protein 6 (hArp6) (hARPX) | Required for formation and/or maintenance of proper nucleolar structure and function (PubMed:26164235). Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (By similarity). In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z (By similarity). {ECO:0000250|UniProtKB:Q9DEE9, ECO:0000269|PubMed:26164235}. |
| Q9H1R3 | MYLK2 | S587 | ochoa | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) | Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}. |
| Q9H6F2 | TMEM38A | S290 | ochoa | Trimeric intracellular cation channel type A (TRIC-A) (TRICA) (Transmembrane protein 38A) | Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Opened by a change of voltage within the sarcoplasmic reticulum lumen (By similarity). {ECO:0000250|UniProtKB:A5A6S6}. |
| Q9H871 | RMND5A | S382 | ochoa | E3 ubiquitin-protein transferase RMND5A (EC 2.3.2.27) (P44CTLH) (Protein RMD5 homolog A) | Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). {ECO:0000269|PubMed:29911972}. |
| Q9HCU9 | BRMS1 | S237 | ochoa|psp | Breast cancer metastasis-suppressor 1 | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}. |
| Q9NR28 | DIABLO | S230 | ochoa | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspases) (SMAC) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] | Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}.; FUNCTION: [Isoform 3]: Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. {ECO:0000269|PubMed:14523016}.; FUNCTION: [Isoform 1]: Defective in the capacity to down-regulate the XIAP/BIRC4 abundance. {ECO:0000269|PubMed:14523016}. |
| Q9NUN5 | LMBRD1 | S531 | ochoa | Lysosomal cobalamin transport escort protein LMBD1 (LMBD1) (HDAg-L-interacting protein NESI) (LMBR1 domain-containing protein 1) (Nuclear export signal-interacting protein) | Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed:19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed:27456980). Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K0B2, ECO:0000269|PubMed:19136951, ECO:0000269|PubMed:27456980, ECO:0000303|PubMed:25535791}.; FUNCTION: [Isoform 3]: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV). {ECO:0000269|PubMed:15956556}. |
| Q9NV56 | MRGBP | S194 | ochoa | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Q9NVN8 | GNL3L | S573 | ochoa | Guanine nucleotide-binding protein-like 3-like protein | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}. |
| Q9NWZ5 | UCKL1 | S539 | ochoa | Uridine-cytidine kinase-like 1 (EC 2.7.1.48) | May contribute to UTP accumulation needed for blast transformation and proliferation. {ECO:0000269|PubMed:12199906}. |
| Q9NX74 | DUS2 | S484 | ochoa | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) | Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057, PubMed:38680565). Specifically modifies U20 in cytoplasmic tRNAs (PubMed:38680565). Activity depends on the presence of guanosine at position 19 in the tRNA substrate (PubMed:38680565). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616). {ECO:0000269|PubMed:15994936, ECO:0000269|PubMed:18096616, ECO:0000269|PubMed:26429968, ECO:0000269|PubMed:30149704, ECO:0000269|PubMed:34798057, ECO:0000269|PubMed:38680565}. |
| Q9NYF0 | DACT1 | S827 | psp | Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein) | Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. {ECO:0000250, ECO:0000269|PubMed:15580286, ECO:0000269|PubMed:16446366, ECO:0000269|PubMed:17197390, ECO:0000269|PubMed:18936100, ECO:0000269|PubMed:22470507}. |
| Q9NZD8 | SPG21 | S300 | ochoa | Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein) | May play a role as a negative regulatory factor in CD4-dependent T-cell activation. {ECO:0000269|PubMed:11113139}. |
| Q9UJS0 | SLC25A13 | S666 | ochoa | Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (Calcium-binding mitochondrial carrier protein Aralar2) (ARALAR-related gene 2) (ARALAR2) (Citrin) (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13) | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards gamma-aminobutyric acid (GABA) (PubMed:38945283). {ECO:0000269|PubMed:11566871, ECO:0000269|PubMed:38945283}. |
| Q9ULW0 | TPX2 | S738 | ochoa|psp | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9UQ80 | PA2G4 | S383 | ochoa | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y237 | PIN4 | Y122 | ochoa|psp | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4) | Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. {ECO:0000269|PubMed:19369196}.; FUNCTION: Isoform 2 binds to double-stranded DNA. {ECO:0000269|PubMed:19369196}. |
| Q9Y383 | LUC7L2 | S383 | ochoa | Putative RNA-binding protein Luc7-like 2 | May bind to RNA via its Arg/Ser-rich domain. |
| Q9Y394 | DHRS7 | S329 | ochoa | Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1) | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28457967, PubMed:28687384). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28457967, PubMed:28687384). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:26311046, ECO:0000269|PubMed:26466768, ECO:0000269|PubMed:28457967, ECO:0000269|PubMed:28687384}. |
| Q9Y3C1 | NOP16 | S169 | ochoa | Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3) | None |
| Q9Y421 | FAM32A | Y103 | ochoa | Protein FAM32A (Ovarian tumor-associated gene 12) (OTAG-12) | Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli. {ECO:0000269|PubMed:21339736}. |
| Q9Y696 | CLIC4 | S245 | ochoa | Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}. |
| P09496 | CLTA | S240 | Sugiyama | Clathrin light chain A (Lca) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). {ECO:0000305|PubMed:15858577, ECO:0000305|PubMed:21297582}. |
| Q16719 | KYNU | S456 | Sugiyama | Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000269|PubMed:11985583, ECO:0000269|PubMed:17300176, ECO:0000269|PubMed:28792876, ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}. |
| P32969 | RPL9 | S182 | Sugiyama | Large ribosomal subunit protein uL6 (60S ribosomal protein L9) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P45974 | USP5 | Y849 | Sugiyama | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| Q9Y394 | DHRS7 | Y330 | Sugiyama | Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1) | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28457967, PubMed:28687384). Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function (PubMed:28457967, PubMed:28687384). Involved in the reduction of all-trans-retinal to all-trans-retinol (PubMed:26466768). Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable (PubMed:28457967). Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group (PubMed:24246760, PubMed:26466768). A dehydrogenase activity has not been detected so far (PubMed:24246760). May play a role as tumor suppressor (PubMed:26311046). {ECO:0000269|PubMed:24246760, ECO:0000269|PubMed:26311046, ECO:0000269|PubMed:26466768, ECO:0000269|PubMed:28457967, ECO:0000269|PubMed:28687384}. |
| Q12996 | CSTF3 | Y708 | Sugiyama | Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. |
| O14561 | NDUFAB1 | Y147 | Sugiyama | Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) | Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) (PubMed:27626371). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). {ECO:0000250|UniProtKB:P52505, ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:27626371, ECO:0000269|PubMed:31664822}. |
| P61221 | ABCE1 | S591 | Sugiyama | ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}. |
| P42766 | RPL35 | Y114 | Sugiyama | Large ribosomal subunit protein uL29 (60S ribosomal protein L35) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q8TA86 | RP9 | S212 | SIGNOR | Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) | Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity). {ECO:0000250}. |
| Q8TA86 | RP9 | S214 | SIGNOR | Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) | Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity). {ECO:0000250}. |
| Q13127 | REST | Y1088 | Sugiyama | RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor) | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250|UniProtKB:O54963, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:10449787, ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:24670762, ECO:0000269|PubMed:26053433, ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:27531581, ECO:0000269|PubMed:7697725, ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:11741002, ECO:0000269|PubMed:11779185}. |
| P02686 | MBP | S295 | SIGNOR|EPSD | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| Q9Y6E0 | STK24 | S434 | Sugiyama | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
| O43493 | TGOLN2 | S428 | Sugiyama | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| P40925 | MDH1 | S326 | Sugiyama | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| Q96FC3 | TPX2 | S204 | GPS6 | TPX2 protein | None |
| P09497 | CLTB | S221 | Sugiyama | Clathrin light chain B (Lcb) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. |
| Q9UGP4 | LIMD1 | S667 | Sugiyama | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 9.907690e-08 | 7.004 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.910824e-08 | 7.309 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.797760e-08 | 7.056 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.187100e-07 | 6.926 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.456185e-07 | 6.610 |
| R-HSA-156902 | Peptide chain elongation | 8.111610e-07 | 6.091 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.127605e-06 | 5.948 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.545519e-06 | 5.811 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.668785e-06 | 5.778 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.668785e-06 | 5.778 |
| R-HSA-72312 | rRNA processing | 2.145598e-06 | 5.668 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.601807e-06 | 5.585 |
| R-HSA-192823 | Viral mRNA Translation | 2.999252e-06 | 5.523 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 3.216832e-06 | 5.493 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.520371e-06 | 5.345 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.520371e-06 | 5.345 |
| R-HSA-9948299 | Ribosome-associated quality control | 4.938043e-06 | 5.306 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 5.867557e-06 | 5.232 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 5.867557e-06 | 5.232 |
| R-HSA-168255 | Influenza Infection | 6.715493e-06 | 5.173 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 8.527796e-06 | 5.069 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 8.527796e-06 | 5.069 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.481560e-05 | 4.829 |
| R-HSA-9824446 | Viral Infection Pathways | 3.648486e-05 | 4.438 |
| R-HSA-9675108 | Nervous system development | 4.539089e-05 | 4.343 |
| R-HSA-72766 | Translation | 6.047427e-05 | 4.218 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 6.773202e-05 | 4.169 |
| R-HSA-422475 | Axon guidance | 6.927614e-05 | 4.159 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.727470e-05 | 4.112 |
| R-HSA-9711097 | Cellular response to starvation | 8.792390e-05 | 4.056 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.008475e-04 | 3.996 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.129490e-04 | 3.947 |
| R-HSA-164843 | 2-LTR circle formation | 3.384835e-04 | 3.470 |
| R-HSA-162592 | Integration of provirus | 5.123297e-04 | 3.290 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 2.459967e-03 | 2.609 |
| R-HSA-8953854 | Metabolism of RNA | 2.766236e-03 | 2.558 |
| R-HSA-177539 | Autointegration results in viral DNA circles | 3.884936e-03 | 2.411 |
| R-HSA-175567 | Integration of viral DNA into host genomic DNA | 3.884936e-03 | 2.411 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 4.764594e-03 | 2.322 |
| R-HSA-196025 | Formation of annular gap junctions | 5.727178e-03 | 2.242 |
| R-HSA-8866904 | Negative regulation of activity of TFAP2 (AP-2) family transcription factors | 5.727178e-03 | 2.242 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 6.608519e-03 | 2.180 |
| R-HSA-190873 | Gap junction degradation | 6.770948e-03 | 2.169 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 7.894192e-03 | 2.103 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 7.894192e-03 | 2.103 |
| R-HSA-9679191 | Potential therapeutics for SARS | 7.641101e-03 | 2.117 |
| R-HSA-5663205 | Infectious disease | 7.445202e-03 | 2.128 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 9.246182e-03 | 2.034 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 1.007159e-02 | 1.997 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 9.823732e-03 | 2.008 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.037238e-02 | 1.984 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.049827e-02 | 1.979 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 1.172403e-02 | 1.931 |
| R-HSA-216083 | Integrin cell surface interactions | 1.179054e-02 | 1.928 |
| R-HSA-373760 | L1CAM interactions | 1.082510e-02 | 1.966 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 1.314856e-02 | 1.881 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 1.314856e-02 | 1.881 |
| R-HSA-2132295 | MHC class II antigen presentation | 1.330959e-02 | 1.876 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.280357e-02 | 1.893 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 1.245926e-02 | 1.905 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.464438e-02 | 1.834 |
| R-HSA-9679506 | SARS-CoV Infections | 1.475303e-02 | 1.831 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.784367e-02 | 1.749 |
| R-HSA-437239 | Recycling pathway of L1 | 1.883727e-02 | 1.725 |
| R-HSA-169131 | Inhibition of PKR | 2.004236e-02 | 1.698 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.313903e-02 | 1.636 |
| R-HSA-9831926 | Nephron development | 2.313903e-02 | 1.636 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.358540e-02 | 1.627 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.467233e-02 | 1.608 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 2.477597e-02 | 1.606 |
| R-HSA-9834899 | Specification of the neural plate border | 2.503062e-02 | 1.602 |
| R-HSA-9629569 | Protein hydroxylation | 2.698307e-02 | 1.569 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 2.993628e-02 | 1.524 |
| R-HSA-983189 | Kinesins | 3.240533e-02 | 1.489 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 3.319158e-02 | 1.479 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.319158e-02 | 1.479 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.537362e-02 | 1.451 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.609771e-02 | 1.443 |
| R-HSA-936837 | Ion transport by P-type ATPases | 3.737464e-02 | 1.427 |
| R-HSA-8866906 | TFAP2 (AP-2) family regulates transcription of other transcription factors | 4.935972e-02 | 1.307 |
| R-HSA-5683329 | Defective ABCD4 causes MAHCJ | 4.935972e-02 | 1.307 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 5.893714e-02 | 1.230 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 6.841866e-02 | 1.165 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 6.841866e-02 | 1.165 |
| R-HSA-187706 | Signalling to p38 via RIT and RIN | 7.780522e-02 | 1.109 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.709778e-02 | 1.060 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.054046e-01 | 0.977 |
| R-HSA-210990 | PECAM1 interactions | 1.321830e-01 | 0.879 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 1.409308e-01 | 0.851 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.581645e-01 | 0.801 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.581645e-01 | 0.801 |
| R-HSA-69166 | Removal of the Flap Intermediate | 1.666520e-01 | 0.778 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 1.666520e-01 | 0.778 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.666520e-01 | 0.778 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 1.750545e-01 | 0.757 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.750545e-01 | 0.757 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 1.833728e-01 | 0.737 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 1.833728e-01 | 0.737 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.916077e-01 | 0.718 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 7.390114e-02 | 1.131 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 1.997601e-01 | 0.699 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 2.078307e-01 | 0.682 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.158205e-01 | 0.666 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.237302e-01 | 0.650 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.237302e-01 | 0.650 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.237302e-01 | 0.650 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.237302e-01 | 0.650 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.237302e-01 | 0.650 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 2.393124e-01 | 0.621 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.695503e-01 | 0.569 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 2.842182e-01 | 0.546 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.985933e-01 | 0.525 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 3.056729e-01 | 0.515 |
| R-HSA-9833482 | PKR-mediated signaling | 2.240299e-01 | 0.650 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 7.780522e-02 | 1.109 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 1.750545e-01 | 0.757 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 5.209030e-02 | 1.283 |
| R-HSA-180292 | GAB1 signalosome | 2.078307e-01 | 0.682 |
| R-HSA-182971 | EGFR downregulation | 3.126815e-01 | 0.505 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.916077e-01 | 0.718 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 1.916077e-01 | 0.718 |
| R-HSA-1236977 | Endosomal/Vacuolar pathway | 1.409308e-01 | 0.851 |
| R-HSA-163615 | PKA activation | 2.078307e-01 | 0.682 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 9.806232e-02 | 1.008 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 2.842182e-01 | 0.546 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.409308e-01 | 0.851 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 1.495910e-01 | 0.825 |
| R-HSA-69186 | Lagging Strand Synthesis | 2.315605e-01 | 0.635 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 4.134263e-02 | 1.384 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 2.769212e-01 | 0.558 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.532748e-01 | 0.596 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 7.680349e-02 | 1.115 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 3.196197e-01 | 0.495 |
| R-HSA-2424491 | DAP12 signaling | 3.056729e-01 | 0.515 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 9.559320e-02 | 1.020 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.366144e-01 | 0.865 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.820738e-02 | 1.166 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.237302e-01 | 0.650 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.274418e-01 | 0.895 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 5.893714e-02 | 1.230 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 7.780522e-02 | 1.109 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 7.780522e-02 | 1.109 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 7.780522e-02 | 1.109 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 8.709778e-02 | 1.060 |
| R-HSA-1369007 | Mitochondrial ABC transporters | 9.629728e-02 | 1.016 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 1.144208e-01 | 0.941 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 1.495910e-01 | 0.825 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 1.495910e-01 | 0.825 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 1.495910e-01 | 0.825 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.916077e-01 | 0.718 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.078307e-01 | 0.682 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.078307e-01 | 0.682 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 8.271405e-02 | 1.082 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.158205e-01 | 0.666 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.621047e-01 | 0.582 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.842182e-01 | 0.546 |
| R-HSA-5693538 | Homology Directed Repair | 1.506474e-01 | 0.822 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.277409e-01 | 0.643 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.532748e-01 | 0.596 |
| R-HSA-69190 | DNA strand elongation | 3.196197e-01 | 0.495 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.621047e-01 | 0.582 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.078307e-01 | 0.682 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.078307e-01 | 0.682 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 2.315605e-01 | 0.635 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.515258e-01 | 0.820 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.144208e-01 | 0.941 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.233466e-01 | 0.909 |
| R-HSA-171007 | p38MAPK events | 1.750545e-01 | 0.757 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.621047e-01 | 0.582 |
| R-HSA-3214815 | HDACs deacetylate histones | 1.342270e-01 | 0.872 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 2.315605e-01 | 0.635 |
| R-HSA-913531 | Interferon Signaling | 2.271302e-01 | 0.644 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 2.985933e-01 | 0.525 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 1.581645e-01 | 0.801 |
| R-HSA-420029 | Tight junction interactions | 2.695503e-01 | 0.569 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 2.018831e-01 | 0.695 |
| R-HSA-9843745 | Adipogenesis | 1.875523e-01 | 0.727 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 2.769212e-01 | 0.558 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 2.695503e-01 | 0.569 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.997601e-01 | 0.699 |
| R-HSA-1236394 | Signaling by ERBB4 | 5.138812e-02 | 1.289 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 9.682851e-02 | 1.014 |
| R-HSA-9707587 | Regulation of HMOX1 expression and activity | 5.893714e-02 | 1.230 |
| R-HSA-6807047 | Cholesterol biosynthesis via desmosterol | 1.321830e-01 | 0.879 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 1.409308e-01 | 0.851 |
| R-HSA-69091 | Polymerase switching | 1.495910e-01 | 0.825 |
| R-HSA-69109 | Leading Strand Synthesis | 1.495910e-01 | 0.825 |
| R-HSA-9857492 | Protein lipoylation | 1.750545e-01 | 0.757 |
| R-HSA-8875878 | MET promotes cell motility | 7.680349e-02 | 1.115 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 2.469865e-01 | 0.607 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 2.842182e-01 | 0.546 |
| R-HSA-165159 | MTOR signalling | 9.182974e-02 | 1.037 |
| R-HSA-611105 | Respiratory electron transport | 1.406941e-01 | 0.852 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 6.084931e-02 | 1.216 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.144208e-01 | 0.941 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 6.266852e-02 | 1.203 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 2.985933e-01 | 0.525 |
| R-HSA-199991 | Membrane Trafficking | 4.021557e-02 | 1.396 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.914420e-01 | 0.535 |
| R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.780522e-02 | 1.109 |
| R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | 7.780522e-02 | 1.109 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.581645e-01 | 0.801 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 1.750545e-01 | 0.757 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.750545e-01 | 0.757 |
| R-HSA-190828 | Gap junction trafficking | 9.806232e-02 | 1.008 |
| R-HSA-167044 | Signalling to RAS | 2.315605e-01 | 0.635 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 2.469865e-01 | 0.607 |
| R-HSA-8874081 | MET activates PTK2 signaling | 2.769212e-01 | 0.558 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 3.056729e-01 | 0.515 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 2.769212e-01 | 0.558 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.364887e-01 | 0.865 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.997601e-01 | 0.699 |
| R-HSA-9694614 | Attachment and Entry | 2.393124e-01 | 0.621 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 9.559320e-02 | 1.020 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 5.761037e-02 | 1.239 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 1.233466e-01 | 0.909 |
| R-HSA-71288 | Creatine metabolism | 2.237302e-01 | 0.650 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.141349e-01 | 0.943 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 2.621047e-01 | 0.582 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 2.695503e-01 | 0.569 |
| R-HSA-180024 | DARPP-32 events | 2.985933e-01 | 0.525 |
| R-HSA-187687 | Signalling to ERKs | 6.820738e-02 | 1.166 |
| R-HSA-8964038 | LDL clearance | 2.469865e-01 | 0.607 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.695503e-01 | 0.569 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.695503e-01 | 0.569 |
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 1.054046e-01 | 0.977 |
| R-HSA-9758881 | Uptake of dietary cobalamins into enterocytes | 1.409308e-01 | 0.851 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.012225e-01 | 0.995 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 3.056729e-01 | 0.515 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.506474e-01 | 0.822 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.836759e-02 | 1.315 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.121798e-01 | 0.950 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 2.351756e-01 | 0.629 |
| R-HSA-8983711 | OAS antiviral response | 1.495910e-01 | 0.825 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 2.842182e-01 | 0.546 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.945583e-01 | 0.711 |
| R-HSA-8852135 | Protein ubiquitination | 2.055575e-01 | 0.687 |
| R-HSA-4086400 | PCP/CE pathway | 2.166230e-01 | 0.664 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.298402e-02 | 1.137 |
| R-HSA-5578775 | Ion homeostasis | 1.376498e-01 | 0.861 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.283511e-02 | 1.138 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.366144e-01 | 0.865 |
| R-HSA-74160 | Gene expression (Transcription) | 2.089558e-01 | 0.680 |
| R-HSA-9758890 | Transport of RCbl within the body | 1.321830e-01 | 0.879 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.495910e-01 | 0.825 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 1.997601e-01 | 0.699 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.076261e-01 | 0.968 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 2.842182e-01 | 0.546 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.900930e-01 | 0.721 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 3.031813e-01 | 0.518 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.158205e-01 | 0.666 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 1.141349e-01 | 0.943 |
| R-HSA-162587 | HIV Life Cycle | 2.613983e-01 | 0.583 |
| R-HSA-111458 | Formation of apoptosome | 1.233466e-01 | 0.909 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 1.997601e-01 | 0.699 |
| R-HSA-210991 | Basigin interactions | 2.315605e-01 | 0.635 |
| R-HSA-73614 | Pyrimidine salvage | 2.914420e-01 | 0.535 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 5.840228e-02 | 1.234 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.781674e-01 | 0.749 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 1.916077e-01 | 0.718 |
| R-HSA-445144 | Signal transduction by L1 | 2.237302e-01 | 0.650 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 2.469865e-01 | 0.607 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 3.126815e-01 | 0.505 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.089795e-01 | 0.680 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.626837e-01 | 0.789 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 1.409308e-01 | 0.851 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 2.545837e-01 | 0.594 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.126815e-01 | 0.505 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 2.762240e-01 | 0.559 |
| R-HSA-212436 | Generic Transcription Pathway | 2.422125e-01 | 0.616 |
| R-HSA-983712 | Ion channel transport | 1.612795e-01 | 0.792 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 1.495910e-01 | 0.825 |
| R-HSA-373753 | Nephrin family interactions | 2.237302e-01 | 0.650 |
| R-HSA-3296469 | Defects in cobalamin (B12) metabolism | 2.695503e-01 | 0.569 |
| R-HSA-2682334 | EPH-Ephrin signaling | 8.578632e-02 | 1.067 |
| R-HSA-1266738 | Developmental Biology | 9.427299e-02 | 1.026 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 1.240809e-01 | 0.906 |
| R-HSA-3000157 | Laminin interactions | 2.695503e-01 | 0.569 |
| R-HSA-109582 | Hemostasis | 2.991414e-01 | 0.524 |
| R-HSA-73942 | DNA Damage Reversal | 1.750545e-01 | 0.757 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.108678e-01 | 0.955 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.186660e-01 | 0.926 |
| R-HSA-166520 | Signaling by NTRKs | 8.925579e-02 | 1.049 |
| R-HSA-5358508 | Mismatch Repair | 2.078307e-01 | 0.682 |
| R-HSA-6806834 | Signaling by MET | 2.240299e-01 | 0.650 |
| R-HSA-4839726 | Chromatin organization | 2.904410e-01 | 0.537 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.585647e-01 | 0.800 |
| R-HSA-195721 | Signaling by WNT | 2.213546e-01 | 0.655 |
| R-HSA-1643685 | Disease | 9.010047e-02 | 1.045 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 1.581645e-01 | 0.801 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 1.997601e-01 | 0.699 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.079187e-01 | 0.967 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 1.445523e-01 | 0.840 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 2.500833e-01 | 0.602 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 1.666520e-01 | 0.778 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.189677e-01 | 0.496 |
| R-HSA-8953897 | Cellular responses to stimuli | 4.896358e-02 | 1.310 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 2.158205e-01 | 0.666 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.872694e-01 | 0.728 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.237271e-01 | 0.650 |
| R-HSA-2262752 | Cellular responses to stress | 1.058580e-01 | 0.975 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 6.541805e-02 | 1.184 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 3.196197e-01 | 0.495 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.352747e-01 | 0.869 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 2.769212e-01 | 0.558 |
| R-HSA-9830369 | Kidney development | 1.764132e-01 | 0.753 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 3.208656e-01 | 0.494 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.264883e-01 | 0.486 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.264883e-01 | 0.486 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.264883e-01 | 0.486 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.264883e-01 | 0.486 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 3.264883e-01 | 0.486 |
| R-HSA-9833110 | RSV-host interactions | 3.282527e-01 | 0.484 |
| R-HSA-390522 | Striated Muscle Contraction | 3.332881e-01 | 0.477 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.332881e-01 | 0.477 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 3.332881e-01 | 0.477 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 3.332881e-01 | 0.477 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.392926e-01 | 0.469 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.392926e-01 | 0.469 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.400196e-01 | 0.468 |
| R-HSA-5696400 | Dual Incision in GG-NER | 3.400196e-01 | 0.468 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.400196e-01 | 0.468 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.400196e-01 | 0.468 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.400196e-01 | 0.468 |
| R-HSA-1980145 | Signaling by NOTCH2 | 3.400196e-01 | 0.468 |
| R-HSA-73894 | DNA Repair | 3.408331e-01 | 0.467 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.429607e-01 | 0.465 |
| R-HSA-375276 | Peptide ligand-binding receptors | 3.437628e-01 | 0.464 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 3.466835e-01 | 0.460 |
| R-HSA-2559585 | Oncogene Induced Senescence | 3.466835e-01 | 0.460 |
| R-HSA-3296482 | Defects in vitamin and cofactor metabolism | 3.466835e-01 | 0.460 |
| R-HSA-9682385 | FLT3 signaling in disease | 3.532805e-01 | 0.452 |
| R-HSA-8941326 | RUNX2 regulates bone development | 3.532805e-01 | 0.452 |
| R-HSA-111933 | Calmodulin induced events | 3.532805e-01 | 0.452 |
| R-HSA-111997 | CaM pathway | 3.532805e-01 | 0.452 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 3.532805e-01 | 0.452 |
| R-HSA-4641258 | Degradation of DVL | 3.598114e-01 | 0.444 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.598114e-01 | 0.444 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.726771e-01 | 0.429 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 3.726771e-01 | 0.429 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 3.726771e-01 | 0.429 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 3.726771e-01 | 0.429 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.756582e-01 | 0.425 |
| R-HSA-71240 | Tryptophan catabolism | 3.790132e-01 | 0.421 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 3.852858e-01 | 0.414 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.852858e-01 | 0.414 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.852858e-01 | 0.414 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 3.914953e-01 | 0.407 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.914953e-01 | 0.407 |
| R-HSA-6811438 | Intra-Golgi traffic | 3.914953e-01 | 0.407 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.953374e-01 | 0.403 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 3.976426e-01 | 0.401 |
| R-HSA-111996 | Ca-dependent events | 3.976426e-01 | 0.401 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 3.976426e-01 | 0.401 |
| R-HSA-1433557 | Signaling by SCF-KIT | 4.037281e-01 | 0.394 |
| R-HSA-162909 | Host Interactions of HIV factors | 4.076802e-01 | 0.390 |
| R-HSA-2172127 | DAP12 interactions | 4.097524e-01 | 0.387 |
| R-HSA-69236 | G1 Phase | 4.097524e-01 | 0.387 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.097524e-01 | 0.387 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.097524e-01 | 0.387 |
| R-HSA-196741 | Cobalamin (Cbl, vitamin B12) transport and metabolism | 4.097524e-01 | 0.387 |
| R-HSA-388396 | GPCR downstream signalling | 4.141884e-01 | 0.383 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.146908e-01 | 0.382 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.146908e-01 | 0.382 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.146908e-01 | 0.382 |
| R-HSA-194138 | Signaling by VEGF | 4.146908e-01 | 0.382 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.157163e-01 | 0.381 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.157163e-01 | 0.381 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 4.157163e-01 | 0.381 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 4.157163e-01 | 0.381 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.157163e-01 | 0.381 |
| R-HSA-397014 | Muscle contraction | 4.174132e-01 | 0.379 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.216203e-01 | 0.375 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.216203e-01 | 0.375 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 4.216203e-01 | 0.375 |
| R-HSA-9675135 | Diseases of DNA repair | 4.216203e-01 | 0.375 |
| R-HSA-75153 | Apoptotic execution phase | 4.216203e-01 | 0.375 |
| R-HSA-69481 | G2/M Checkpoints | 4.216602e-01 | 0.375 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 4.274650e-01 | 0.369 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.332510e-01 | 0.363 |
| R-HSA-9634597 | GPER1 signaling | 4.332510e-01 | 0.363 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 4.332510e-01 | 0.363 |
| R-HSA-9031628 | NGF-stimulated transcription | 4.332510e-01 | 0.363 |
| R-HSA-389356 | Co-stimulation by CD28 | 4.332510e-01 | 0.363 |
| R-HSA-5576891 | Cardiac conduction | 4.388963e-01 | 0.358 |
| R-HSA-73893 | DNA Damage Bypass | 4.389789e-01 | 0.358 |
| R-HSA-162582 | Signal Transduction | 4.412928e-01 | 0.355 |
| R-HSA-1500931 | Cell-Cell communication | 4.428063e-01 | 0.354 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 4.502627e-01 | 0.347 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.502627e-01 | 0.347 |
| R-HSA-9864848 | Complex IV assembly | 4.502627e-01 | 0.347 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 4.558196e-01 | 0.341 |
| R-HSA-72187 | mRNA 3'-end processing | 4.558196e-01 | 0.341 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 4.558196e-01 | 0.341 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 4.558196e-01 | 0.341 |
| R-HSA-162906 | HIV Infection | 4.572334e-01 | 0.340 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.584039e-01 | 0.339 |
| R-HSA-1640170 | Cell Cycle | 4.588833e-01 | 0.338 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.592076e-01 | 0.338 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.598494e-01 | 0.337 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 4.613208e-01 | 0.336 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 4.613208e-01 | 0.336 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 4.613208e-01 | 0.336 |
| R-HSA-1221632 | Meiotic synapsis | 4.613208e-01 | 0.336 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.625517e-01 | 0.335 |
| R-HSA-5368287 | Mitochondrial translation | 4.658838e-01 | 0.332 |
| R-HSA-72649 | Translation initiation complex formation | 4.667667e-01 | 0.331 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 4.667667e-01 | 0.331 |
| R-HSA-418597 | G alpha (z) signalling events | 4.721578e-01 | 0.326 |
| R-HSA-9012852 | Signaling by NOTCH3 | 4.721578e-01 | 0.326 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.754313e-01 | 0.323 |
| R-HSA-1474244 | Extracellular matrix organization | 4.760501e-01 | 0.322 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 4.774948e-01 | 0.321 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.774948e-01 | 0.321 |
| R-HSA-177929 | Signaling by EGFR | 4.774948e-01 | 0.321 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 4.774948e-01 | 0.321 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 4.774948e-01 | 0.321 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.823607e-01 | 0.317 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 4.831459e-01 | 0.316 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 4.880084e-01 | 0.312 |
| R-HSA-6782135 | Dual incision in TC-NER | 4.880084e-01 | 0.312 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.880084e-01 | 0.312 |
| R-HSA-180786 | Extension of Telomeres | 4.931861e-01 | 0.307 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.983118e-01 | 0.302 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.983118e-01 | 0.302 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.983118e-01 | 0.302 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.983118e-01 | 0.302 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.983118e-01 | 0.302 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.983118e-01 | 0.302 |
| R-HSA-69242 | S Phase | 5.017177e-01 | 0.300 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 5.033859e-01 | 0.298 |
| R-HSA-112043 | PLC beta mediated events | 5.033859e-01 | 0.298 |
| R-HSA-445717 | Aquaporin-mediated transport | 5.033859e-01 | 0.298 |
| R-HSA-8956321 | Nucleotide salvage | 5.033859e-01 | 0.298 |
| R-HSA-9758941 | Gastrulation | 5.048988e-01 | 0.297 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 5.084090e-01 | 0.294 |
| R-HSA-6784531 | tRNA processing in the nucleus | 5.084090e-01 | 0.294 |
| R-HSA-1268020 | Mitochondrial protein import | 5.084090e-01 | 0.294 |
| R-HSA-6799198 | Complex I biogenesis | 5.133816e-01 | 0.290 |
| R-HSA-373755 | Semaphorin interactions | 5.133816e-01 | 0.290 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 5.133816e-01 | 0.290 |
| R-HSA-8848021 | Signaling by PTK6 | 5.133816e-01 | 0.290 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 5.133816e-01 | 0.290 |
| R-HSA-421270 | Cell-cell junction organization | 5.184144e-01 | 0.285 |
| R-HSA-1234174 | Cellular response to hypoxia | 5.231773e-01 | 0.281 |
| R-HSA-1989781 | PPARA activates gene expression | 5.237088e-01 | 0.281 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 5.280015e-01 | 0.277 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 5.280015e-01 | 0.277 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 5.298723e-01 | 0.276 |
| R-HSA-372790 | Signaling by GPCR | 5.327499e-01 | 0.273 |
| R-HSA-112040 | G-protein mediated events | 5.327771e-01 | 0.273 |
| R-HSA-6798695 | Neutrophil degranulation | 5.330096e-01 | 0.273 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.355626e-01 | 0.271 |
| R-HSA-877300 | Interferon gamma signaling | 5.359818e-01 | 0.271 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 5.375046e-01 | 0.270 |
| R-HSA-109581 | Apoptosis | 5.450443e-01 | 0.264 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.468177e-01 | 0.262 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.468177e-01 | 0.262 |
| R-HSA-416476 | G alpha (q) signalling events | 5.499859e-01 | 0.260 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.514040e-01 | 0.259 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 5.514040e-01 | 0.259 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 5.514040e-01 | 0.259 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 5.514040e-01 | 0.259 |
| R-HSA-3000178 | ECM proteoglycans | 5.514040e-01 | 0.259 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.559443e-01 | 0.255 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 5.559443e-01 | 0.255 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 5.559443e-01 | 0.255 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 5.648882e-01 | 0.248 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.648882e-01 | 0.248 |
| R-HSA-9013694 | Signaling by NOTCH4 | 5.648882e-01 | 0.248 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 5.692928e-01 | 0.245 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 5.692928e-01 | 0.245 |
| R-HSA-72306 | tRNA processing | 5.714908e-01 | 0.243 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.734357e-01 | 0.242 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.736530e-01 | 0.241 |
| R-HSA-1980143 | Signaling by NOTCH1 | 5.736530e-01 | 0.241 |
| R-HSA-418555 | G alpha (s) signalling events | 5.743601e-01 | 0.241 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.800571e-01 | 0.237 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.800571e-01 | 0.237 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.822424e-01 | 0.235 |
| R-HSA-416482 | G alpha (12/13) signalling events | 5.822424e-01 | 0.235 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.822424e-01 | 0.235 |
| R-HSA-5619084 | ABC transporter disorders | 5.822424e-01 | 0.235 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 5.822424e-01 | 0.235 |
| R-HSA-446728 | Cell junction organization | 5.826030e-01 | 0.235 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.848755e-01 | 0.233 |
| R-HSA-9659379 | Sensory processing of sound | 5.864723e-01 | 0.232 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 5.906597e-01 | 0.229 |
| R-HSA-2559583 | Cellular Senescence | 5.995578e-01 | 0.222 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 6.069921e-01 | 0.217 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 6.076443e-01 | 0.216 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 6.077060e-01 | 0.216 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 6.109729e-01 | 0.214 |
| R-HSA-1500620 | Meiosis | 6.109729e-01 | 0.214 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 6.149137e-01 | 0.211 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 6.149137e-01 | 0.211 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 6.149137e-01 | 0.211 |
| R-HSA-69275 | G2/M Transition | 6.157287e-01 | 0.211 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 6.210075e-01 | 0.207 |
| R-HSA-70268 | Pyruvate metabolism | 6.226766e-01 | 0.206 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.226766e-01 | 0.206 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.302839e-01 | 0.200 |
| R-HSA-418594 | G alpha (i) signalling events | 6.318339e-01 | 0.199 |
| R-HSA-73884 | Base Excision Repair | 6.340302e-01 | 0.198 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 6.365105e-01 | 0.196 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.415674e-01 | 0.193 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 6.522033e-01 | 0.186 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 6.557289e-01 | 0.183 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 6.557289e-01 | 0.183 |
| R-HSA-5389840 | Mitochondrial translation elongation | 6.626737e-01 | 0.179 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.626737e-01 | 0.179 |
| R-HSA-72172 | mRNA Splicing | 6.636437e-01 | 0.178 |
| R-HSA-5357801 | Programmed Cell Death | 6.660284e-01 | 0.177 |
| R-HSA-157579 | Telomere Maintenance | 6.660937e-01 | 0.176 |
| R-HSA-392499 | Metabolism of proteins | 6.694245e-01 | 0.174 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 6.694793e-01 | 0.174 |
| R-HSA-5368286 | Mitochondrial translation initiation | 6.694793e-01 | 0.174 |
| R-HSA-422356 | Regulation of insulin secretion | 6.694793e-01 | 0.174 |
| R-HSA-3214847 | HATs acetylate histones | 6.728307e-01 | 0.172 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 6.761484e-01 | 0.170 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.761484e-01 | 0.170 |
| R-HSA-5610787 | Hedgehog 'off' state | 6.761484e-01 | 0.170 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 6.794326e-01 | 0.168 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.826837e-01 | 0.166 |
| R-HSA-111885 | Opioid Signalling | 6.890880e-01 | 0.162 |
| R-HSA-382551 | Transport of small molecules | 6.905572e-01 | 0.161 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.922418e-01 | 0.160 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.922418e-01 | 0.160 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.953638e-01 | 0.158 |
| R-HSA-418990 | Adherens junctions interactions | 6.958087e-01 | 0.158 |
| R-HSA-418346 | Platelet homeostasis | 6.984543e-01 | 0.156 |
| R-HSA-69239 | Synthesis of DNA | 7.015136e-01 | 0.154 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 7.045421e-01 | 0.152 |
| R-HSA-2672351 | Stimuli-sensing channels | 7.045421e-01 | 0.152 |
| R-HSA-5419276 | Mitochondrial translation termination | 7.075401e-01 | 0.150 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 7.075401e-01 | 0.150 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.119998e-01 | 0.148 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.130291e-01 | 0.147 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.192746e-01 | 0.143 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.203990e-01 | 0.142 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 7.249034e-01 | 0.140 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.276960e-01 | 0.138 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 7.304604e-01 | 0.136 |
| R-HSA-15869 | Metabolism of nucleotides | 7.334062e-01 | 0.135 |
| R-HSA-8939211 | ESR-mediated signaling | 7.353752e-01 | 0.133 |
| R-HSA-9007101 | Rab regulation of trafficking | 7.359058e-01 | 0.133 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 7.412418e-01 | 0.130 |
| R-HSA-68875 | Mitotic Prophase | 7.438695e-01 | 0.129 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 7.464707e-01 | 0.127 |
| R-HSA-73886 | Chromosome Maintenance | 7.464707e-01 | 0.127 |
| R-HSA-3371556 | Cellular response to heat stress | 7.464707e-01 | 0.127 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 7.515946e-01 | 0.124 |
| R-HSA-69206 | G1/S Transition | 7.590880e-01 | 0.120 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 7.615355e-01 | 0.118 |
| R-HSA-114608 | Platelet degranulation | 7.639583e-01 | 0.117 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 7.710810e-01 | 0.113 |
| R-HSA-1474165 | Reproduction | 7.734074e-01 | 0.112 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 7.802466e-01 | 0.108 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.823911e-01 | 0.107 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 7.890474e-01 | 0.103 |
| R-HSA-163685 | Integration of energy metabolism | 7.890474e-01 | 0.103 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.905509e-01 | 0.102 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.933156e-01 | 0.101 |
| R-HSA-6807070 | PTEN Regulation | 7.954173e-01 | 0.099 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 8.114844e-01 | 0.091 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.134025e-01 | 0.090 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.190412e-01 | 0.087 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 8.219588e-01 | 0.085 |
| R-HSA-69306 | DNA Replication | 8.245104e-01 | 0.084 |
| R-HSA-9609507 | Protein localization | 8.245104e-01 | 0.084 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.314564e-01 | 0.080 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.431955e-01 | 0.074 |
| R-HSA-1280218 | Adaptive Immune System | 8.523987e-01 | 0.069 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 8.584593e-01 | 0.066 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 8.584593e-01 | 0.066 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.584593e-01 | 0.066 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 8.599020e-01 | 0.066 |
| R-HSA-500792 | GPCR ligand binding | 8.686740e-01 | 0.061 |
| R-HSA-68877 | Mitotic Prometaphase | 8.846964e-01 | 0.053 |
| R-HSA-9609690 | HCMV Early Events | 8.881908e-01 | 0.051 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.948670e-01 | 0.048 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.017284e-01 | 0.045 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 9.060942e-01 | 0.043 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 9.070538e-01 | 0.042 |
| R-HSA-68882 | Mitotic Anaphase | 9.098743e-01 | 0.041 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 9.107954e-01 | 0.041 |
| R-HSA-8951664 | Neddylation | 9.143874e-01 | 0.039 |
| R-HSA-68886 | M Phase | 9.167274e-01 | 0.038 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.219522e-01 | 0.035 |
| R-HSA-157118 | Signaling by NOTCH | 9.295806e-01 | 0.032 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.344748e-01 | 0.029 |
| R-HSA-168249 | Innate Immune System | 9.353894e-01 | 0.029 |
| R-HSA-9609646 | HCMV Infection | 9.364675e-01 | 0.029 |
| R-HSA-5688426 | Deubiquitination | 9.396555e-01 | 0.027 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.402738e-01 | 0.027 |
| R-HSA-168256 | Immune System | 9.505396e-01 | 0.022 |
| R-HSA-9824443 | Parasitic Infection Pathways | 9.538408e-01 | 0.021 |
| R-HSA-9658195 | Leishmania infection | 9.538408e-01 | 0.021 |
| R-HSA-597592 | Post-translational protein modification | 9.593528e-01 | 0.018 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.687004e-01 | 0.014 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.700873e-01 | 0.013 |
| R-HSA-8957322 | Metabolism of steroids | 9.703951e-01 | 0.013 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.804362e-01 | 0.009 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.841026e-01 | 0.007 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.862542e-01 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 9.876114e-01 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.894014e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.899389e-01 | 0.004 |
| R-HSA-112316 | Neuronal System | 9.934385e-01 | 0.003 |
| R-HSA-1430728 | Metabolism | 9.956795e-01 | 0.002 |
| R-HSA-556833 | Metabolism of lipids | 9.998980e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999983e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CLK3 |
0.874 | 0.363 | 1 | 0.832 |
COT |
0.870 | 0.250 | 2 | 0.895 |
MOS |
0.854 | 0.152 | 1 | 0.851 |
PIM3 |
0.852 | 0.110 | -3 | 0.828 |
CAMK2G |
0.852 | 0.074 | 2 | 0.855 |
MTOR |
0.852 | 0.043 | 1 | 0.803 |
MST4 |
0.851 | 0.198 | 2 | 0.875 |
PIM1 |
0.850 | 0.167 | -3 | 0.780 |
CAMK1B |
0.850 | 0.077 | -3 | 0.859 |
IKKB |
0.849 | 0.025 | -2 | 0.755 |
DSTYK |
0.849 | 0.104 | 2 | 0.908 |
PRPK |
0.849 | -0.058 | -1 | 0.885 |
CDC7 |
0.849 | 0.001 | 1 | 0.809 |
SRPK1 |
0.849 | 0.161 | -3 | 0.733 |
RSK2 |
0.848 | 0.128 | -3 | 0.762 |
NLK |
0.848 | 0.121 | 1 | 0.857 |
GRK1 |
0.848 | 0.175 | -2 | 0.803 |
RAF1 |
0.847 | 0.011 | 1 | 0.831 |
NDR2 |
0.845 | 0.045 | -3 | 0.842 |
PKN3 |
0.845 | 0.080 | -3 | 0.824 |
CDKL1 |
0.844 | 0.060 | -3 | 0.788 |
PKCD |
0.844 | 0.182 | 2 | 0.818 |
GRK6 |
0.844 | 0.124 | 1 | 0.809 |
BMPR2 |
0.843 | -0.027 | -2 | 0.886 |
CLK2 |
0.843 | 0.249 | -3 | 0.742 |
PKN2 |
0.843 | 0.120 | -3 | 0.836 |
SRPK2 |
0.842 | 0.143 | -3 | 0.662 |
NIK |
0.842 | 0.074 | -3 | 0.878 |
WNK1 |
0.841 | 0.059 | -2 | 0.867 |
PDHK4 |
0.841 | -0.217 | 1 | 0.847 |
MLK1 |
0.841 | 0.067 | 2 | 0.830 |
NUAK2 |
0.840 | 0.050 | -3 | 0.842 |
CAMLCK |
0.840 | 0.063 | -2 | 0.881 |
GCN2 |
0.840 | -0.132 | 2 | 0.782 |
NDR1 |
0.840 | 0.041 | -3 | 0.834 |
TBK1 |
0.840 | -0.060 | 1 | 0.757 |
P70S6KB |
0.839 | 0.087 | -3 | 0.796 |
PRKD2 |
0.839 | 0.089 | -3 | 0.764 |
CDK1 |
0.839 | 0.198 | 1 | 0.697 |
GRK5 |
0.839 | -0.039 | -3 | 0.863 |
CLK4 |
0.839 | 0.173 | -3 | 0.765 |
GRK7 |
0.839 | 0.190 | 1 | 0.743 |
ATR |
0.838 | -0.055 | 1 | 0.772 |
BMPR1B |
0.838 | 0.198 | 1 | 0.756 |
IKKE |
0.838 | -0.048 | 1 | 0.757 |
PKACG |
0.838 | 0.107 | -2 | 0.805 |
CAMK2B |
0.838 | 0.122 | 2 | 0.843 |
SKMLCK |
0.838 | 0.058 | -2 | 0.874 |
ULK2 |
0.838 | -0.121 | 2 | 0.772 |
ERK5 |
0.837 | 0.020 | 1 | 0.801 |
NEK6 |
0.837 | 0.000 | -2 | 0.852 |
FAM20C |
0.837 | 0.165 | 2 | 0.703 |
IKKA |
0.837 | 0.052 | -2 | 0.734 |
CAMK2A |
0.836 | 0.111 | 2 | 0.848 |
TGFBR2 |
0.836 | 0.023 | -2 | 0.835 |
SRPK3 |
0.836 | 0.121 | -3 | 0.710 |
KIS |
0.836 | 0.116 | 1 | 0.747 |
CLK1 |
0.836 | 0.179 | -3 | 0.744 |
CDKL5 |
0.835 | 0.034 | -3 | 0.779 |
NEK7 |
0.835 | -0.071 | -3 | 0.828 |
MAPKAPK2 |
0.835 | 0.067 | -3 | 0.729 |
ICK |
0.835 | 0.056 | -3 | 0.825 |
P90RSK |
0.835 | 0.037 | -3 | 0.761 |
RSK4 |
0.835 | 0.132 | -3 | 0.736 |
CHAK2 |
0.835 | -0.001 | -1 | 0.867 |
PRKX |
0.834 | 0.189 | -3 | 0.687 |
PDHK1 |
0.834 | -0.206 | 1 | 0.840 |
RSK3 |
0.834 | 0.047 | -3 | 0.756 |
DAPK2 |
0.834 | 0.002 | -3 | 0.861 |
RIPK3 |
0.833 | -0.072 | 3 | 0.680 |
PKCG |
0.833 | 0.139 | 2 | 0.780 |
CAMK2D |
0.833 | -0.009 | -3 | 0.833 |
AMPKA1 |
0.833 | 0.010 | -3 | 0.853 |
TSSK2 |
0.833 | 0.047 | -5 | 0.848 |
MLK3 |
0.833 | 0.125 | 2 | 0.780 |
MAPKAPK3 |
0.833 | 0.011 | -3 | 0.775 |
PRKD1 |
0.833 | 0.005 | -3 | 0.807 |
LATS2 |
0.833 | 0.011 | -5 | 0.762 |
LATS1 |
0.832 | 0.114 | -3 | 0.855 |
TGFBR1 |
0.832 | 0.127 | -2 | 0.839 |
HIPK4 |
0.832 | 0.038 | 1 | 0.817 |
AURC |
0.832 | 0.123 | -2 | 0.735 |
ALK4 |
0.831 | 0.092 | -2 | 0.864 |
PKR |
0.831 | 0.111 | 1 | 0.826 |
PKCB |
0.831 | 0.130 | 2 | 0.769 |
CDK5 |
0.830 | 0.173 | 1 | 0.734 |
PKCA |
0.830 | 0.133 | 2 | 0.761 |
DLK |
0.830 | -0.080 | 1 | 0.798 |
GRK4 |
0.829 | -0.031 | -2 | 0.825 |
HUNK |
0.829 | -0.131 | 2 | 0.787 |
MARK4 |
0.829 | -0.062 | 4 | 0.785 |
PKCH |
0.829 | 0.122 | 2 | 0.746 |
CDK3 |
0.829 | 0.208 | 1 | 0.642 |
PKACB |
0.829 | 0.135 | -2 | 0.749 |
PAK1 |
0.828 | 0.056 | -2 | 0.817 |
TSSK1 |
0.828 | 0.034 | -3 | 0.866 |
ANKRD3 |
0.827 | -0.079 | 1 | 0.829 |
CDK2 |
0.827 | 0.142 | 1 | 0.762 |
PLK1 |
0.827 | 0.003 | -2 | 0.814 |
ULK1 |
0.827 | -0.158 | -3 | 0.822 |
JNK3 |
0.827 | 0.136 | 1 | 0.717 |
DYRK2 |
0.826 | 0.098 | 1 | 0.763 |
MSK2 |
0.826 | 0.021 | -3 | 0.730 |
AMPKA2 |
0.826 | -0.001 | -3 | 0.823 |
CAMK4 |
0.826 | -0.025 | -3 | 0.830 |
ALK2 |
0.826 | 0.125 | -2 | 0.848 |
AKT2 |
0.826 | 0.106 | -3 | 0.685 |
BCKDK |
0.826 | -0.153 | -1 | 0.818 |
CDK8 |
0.825 | 0.066 | 1 | 0.712 |
JNK2 |
0.825 | 0.142 | 1 | 0.689 |
WNK3 |
0.825 | -0.189 | 1 | 0.790 |
IRE1 |
0.825 | -0.001 | 1 | 0.773 |
MSK1 |
0.825 | 0.076 | -3 | 0.742 |
IRE2 |
0.825 | 0.052 | 2 | 0.750 |
ATM |
0.825 | -0.036 | 1 | 0.700 |
ACVR2A |
0.825 | 0.086 | -2 | 0.823 |
MYLK4 |
0.824 | 0.061 | -2 | 0.820 |
ACVR2B |
0.824 | 0.090 | -2 | 0.832 |
AURA |
0.824 | 0.106 | -2 | 0.701 |
PIM2 |
0.824 | 0.091 | -3 | 0.745 |
PLK3 |
0.824 | 0.010 | 2 | 0.793 |
AURB |
0.824 | 0.097 | -2 | 0.731 |
PRKD3 |
0.823 | 0.037 | -3 | 0.740 |
MLK4 |
0.823 | 0.052 | 2 | 0.732 |
NEK9 |
0.823 | -0.155 | 2 | 0.823 |
MNK1 |
0.822 | 0.087 | -2 | 0.841 |
YSK4 |
0.822 | -0.026 | 1 | 0.768 |
PKG2 |
0.822 | 0.102 | -2 | 0.756 |
MASTL |
0.822 | -0.300 | -2 | 0.808 |
CAMK1G |
0.822 | 0.037 | -3 | 0.760 |
MEK1 |
0.822 | -0.099 | 2 | 0.821 |
BMPR1A |
0.821 | 0.157 | 1 | 0.733 |
MNK2 |
0.821 | 0.049 | -2 | 0.829 |
CK2A2 |
0.821 | 0.209 | 1 | 0.710 |
TTBK2 |
0.821 | -0.138 | 2 | 0.697 |
PAK3 |
0.820 | -0.016 | -2 | 0.817 |
GSK3A |
0.820 | 0.145 | 4 | 0.544 |
PKCZ |
0.820 | 0.034 | 2 | 0.780 |
CDK13 |
0.820 | 0.080 | 1 | 0.710 |
MLK2 |
0.820 | -0.144 | 2 | 0.816 |
RIPK1 |
0.820 | -0.196 | 1 | 0.796 |
PAK6 |
0.819 | 0.079 | -2 | 0.761 |
HIPK1 |
0.819 | 0.122 | 1 | 0.779 |
DRAK1 |
0.819 | -0.006 | 1 | 0.736 |
QIK |
0.819 | -0.079 | -3 | 0.836 |
DNAPK |
0.819 | 0.005 | 1 | 0.678 |
CHAK1 |
0.819 | -0.034 | 2 | 0.753 |
MST3 |
0.818 | 0.138 | 2 | 0.845 |
NIM1 |
0.818 | -0.112 | 3 | 0.714 |
SGK3 |
0.818 | 0.068 | -3 | 0.759 |
CDK10 |
0.818 | 0.180 | 1 | 0.704 |
HIPK2 |
0.818 | 0.126 | 1 | 0.690 |
GRK2 |
0.818 | -0.005 | -2 | 0.724 |
VRK2 |
0.817 | -0.212 | 1 | 0.851 |
CDK19 |
0.817 | 0.058 | 1 | 0.680 |
TAO3 |
0.817 | 0.120 | 1 | 0.784 |
SIK |
0.817 | -0.017 | -3 | 0.771 |
PAK2 |
0.817 | -0.004 | -2 | 0.805 |
P38A |
0.817 | 0.080 | 1 | 0.748 |
PKCE |
0.817 | 0.177 | 2 | 0.760 |
PHKG1 |
0.817 | -0.025 | -3 | 0.822 |
MEKK3 |
0.817 | -0.015 | 1 | 0.786 |
MELK |
0.817 | -0.047 | -3 | 0.805 |
ERK2 |
0.817 | 0.090 | 1 | 0.729 |
PASK |
0.817 | 0.075 | -3 | 0.843 |
BRSK1 |
0.816 | -0.044 | -3 | 0.791 |
CDK18 |
0.816 | 0.102 | 1 | 0.669 |
QSK |
0.816 | -0.038 | 4 | 0.763 |
CDK7 |
0.816 | 0.037 | 1 | 0.726 |
GSK3B |
0.816 | 0.088 | 4 | 0.534 |
P38B |
0.815 | 0.096 | 1 | 0.694 |
ERK1 |
0.815 | 0.096 | 1 | 0.687 |
CHK1 |
0.815 | -0.028 | -3 | 0.838 |
P38G |
0.815 | 0.112 | 1 | 0.621 |
PKACA |
0.815 | 0.111 | -2 | 0.713 |
GAK |
0.815 | 0.147 | 1 | 0.820 |
MARK3 |
0.815 | -0.028 | 4 | 0.717 |
NUAK1 |
0.814 | -0.060 | -3 | 0.800 |
SMMLCK |
0.814 | 0.042 | -3 | 0.812 |
CDK17 |
0.814 | 0.102 | 1 | 0.626 |
NEK2 |
0.814 | -0.093 | 2 | 0.793 |
AKT1 |
0.814 | 0.106 | -3 | 0.705 |
DCAMKL1 |
0.814 | 0.022 | -3 | 0.786 |
PINK1 |
0.814 | -0.048 | 1 | 0.827 |
BRAF |
0.813 | -0.049 | -4 | 0.749 |
TLK2 |
0.813 | -0.060 | 1 | 0.748 |
HRI |
0.813 | -0.080 | -2 | 0.858 |
PKCT |
0.813 | 0.081 | 2 | 0.754 |
PERK |
0.812 | -0.073 | -2 | 0.857 |
CK2A1 |
0.812 | 0.191 | 1 | 0.692 |
DYRK4 |
0.812 | 0.108 | 1 | 0.697 |
CDK12 |
0.811 | 0.073 | 1 | 0.688 |
CK1E |
0.811 | 0.046 | -3 | 0.584 |
ZAK |
0.810 | -0.060 | 1 | 0.760 |
CDK16 |
0.810 | 0.144 | 1 | 0.641 |
MEK5 |
0.810 | -0.152 | 2 | 0.812 |
MARK2 |
0.810 | -0.065 | 4 | 0.683 |
CDK14 |
0.810 | 0.104 | 1 | 0.718 |
PHKG2 |
0.810 | 0.037 | -3 | 0.805 |
DYRK3 |
0.810 | 0.104 | 1 | 0.785 |
MEKK2 |
0.810 | -0.014 | 2 | 0.794 |
BRSK2 |
0.810 | -0.102 | -3 | 0.817 |
PKCI |
0.809 | 0.072 | 2 | 0.751 |
DCAMKL2 |
0.809 | -0.006 | -3 | 0.812 |
CDK9 |
0.809 | 0.037 | 1 | 0.717 |
P70S6K |
0.809 | 0.022 | -3 | 0.707 |
DYRK1B |
0.809 | 0.086 | 1 | 0.727 |
CAMK1D |
0.808 | 0.039 | -3 | 0.690 |
DYRK1A |
0.808 | 0.045 | 1 | 0.781 |
MARK1 |
0.808 | -0.074 | 4 | 0.733 |
TAO2 |
0.807 | 0.053 | 2 | 0.863 |
WNK4 |
0.807 | -0.096 | -2 | 0.850 |
HIPK3 |
0.807 | 0.060 | 1 | 0.774 |
EEF2K |
0.807 | 0.108 | 3 | 0.847 |
GCK |
0.807 | 0.116 | 1 | 0.803 |
MEKK1 |
0.806 | -0.136 | 1 | 0.788 |
CK1D |
0.806 | 0.056 | -3 | 0.538 |
TLK1 |
0.806 | -0.074 | -2 | 0.836 |
TNIK |
0.806 | 0.166 | 3 | 0.832 |
SSTK |
0.806 | 0.001 | 4 | 0.747 |
GRK3 |
0.805 | 0.008 | -2 | 0.685 |
PRP4 |
0.805 | -0.022 | -3 | 0.693 |
MPSK1 |
0.805 | 0.019 | 1 | 0.771 |
SMG1 |
0.805 | -0.157 | 1 | 0.722 |
PDHK3_TYR |
0.805 | 0.214 | 4 | 0.869 |
JNK1 |
0.805 | 0.099 | 1 | 0.680 |
PLK4 |
0.804 | -0.127 | 2 | 0.622 |
CK1A2 |
0.804 | 0.054 | -3 | 0.537 |
SNRK |
0.804 | -0.187 | 2 | 0.671 |
NEK8 |
0.804 | -0.051 | 2 | 0.817 |
NEK5 |
0.804 | -0.116 | 1 | 0.790 |
IRAK4 |
0.803 | -0.071 | 1 | 0.773 |
DAPK3 |
0.803 | 0.056 | -3 | 0.798 |
MAPKAPK5 |
0.803 | -0.137 | -3 | 0.705 |
SGK1 |
0.802 | 0.087 | -3 | 0.603 |
HPK1 |
0.802 | 0.102 | 1 | 0.807 |
PLK2 |
0.802 | 0.049 | -3 | 0.783 |
MST2 |
0.802 | 0.041 | 1 | 0.797 |
CDK6 |
0.801 | 0.128 | 1 | 0.694 |
CAMKK1 |
0.801 | -0.109 | -2 | 0.774 |
MINK |
0.801 | 0.083 | 1 | 0.792 |
P38D |
0.801 | 0.099 | 1 | 0.625 |
MRCKA |
0.801 | 0.093 | -3 | 0.760 |
HGK |
0.801 | 0.075 | 3 | 0.824 |
NEK11 |
0.801 | -0.106 | 1 | 0.792 |
AKT3 |
0.800 | 0.089 | -3 | 0.614 |
CK1G1 |
0.800 | 0.010 | -3 | 0.582 |
DAPK1 |
0.799 | 0.055 | -3 | 0.778 |
MRCKB |
0.799 | 0.098 | -3 | 0.742 |
KHS2 |
0.799 | 0.166 | 1 | 0.809 |
TAK1 |
0.799 | 0.039 | 1 | 0.778 |
MST1 |
0.798 | 0.064 | 1 | 0.788 |
CDK4 |
0.798 | 0.108 | 1 | 0.678 |
ROCK2 |
0.798 | 0.109 | -3 | 0.788 |
TTBK1 |
0.797 | -0.145 | 2 | 0.631 |
ERK7 |
0.797 | 0.010 | 2 | 0.530 |
LRRK2 |
0.797 | -0.057 | 2 | 0.838 |
CAMKK2 |
0.797 | -0.125 | -2 | 0.778 |
PAK5 |
0.797 | 0.019 | -2 | 0.699 |
PKN1 |
0.796 | 0.015 | -3 | 0.722 |
PDK1 |
0.796 | -0.101 | 1 | 0.791 |
KHS1 |
0.796 | 0.115 | 1 | 0.798 |
PDHK4_TYR |
0.796 | 0.094 | 2 | 0.888 |
BMPR2_TYR |
0.795 | 0.097 | -1 | 0.901 |
TESK1_TYR |
0.795 | 0.010 | 3 | 0.825 |
MAK |
0.795 | 0.100 | -2 | 0.721 |
LOK |
0.795 | 0.018 | -2 | 0.798 |
DMPK1 |
0.795 | 0.137 | -3 | 0.759 |
BUB1 |
0.795 | 0.113 | -5 | 0.799 |
SLK |
0.795 | 0.004 | -2 | 0.737 |
MAP2K6_TYR |
0.795 | 0.071 | -1 | 0.901 |
CHK2 |
0.794 | 0.010 | -3 | 0.631 |
PAK4 |
0.793 | 0.021 | -2 | 0.705 |
PINK1_TYR |
0.793 | 0.052 | 1 | 0.814 |
CAMK1A |
0.793 | 0.024 | -3 | 0.653 |
MAP2K4_TYR |
0.793 | -0.023 | -1 | 0.897 |
MOK |
0.793 | 0.091 | 1 | 0.779 |
NEK4 |
0.793 | -0.108 | 1 | 0.784 |
IRAK1 |
0.792 | -0.244 | -1 | 0.784 |
LKB1 |
0.791 | -0.158 | -3 | 0.813 |
PDHK1_TYR |
0.791 | 0.035 | -1 | 0.918 |
MAP2K7_TYR |
0.791 | -0.111 | 2 | 0.863 |
PKMYT1_TYR |
0.790 | -0.056 | 3 | 0.785 |
STK33 |
0.790 | -0.097 | 2 | 0.631 |
MAP3K15 |
0.790 | -0.105 | 1 | 0.746 |
LIMK2_TYR |
0.789 | 0.029 | -3 | 0.877 |
NEK1 |
0.788 | -0.094 | 1 | 0.778 |
SBK |
0.788 | 0.025 | -3 | 0.566 |
YSK1 |
0.788 | -0.007 | 2 | 0.804 |
VRK1 |
0.788 | -0.159 | 2 | 0.835 |
HASPIN |
0.787 | 0.064 | -1 | 0.712 |
MEKK6 |
0.786 | -0.141 | 1 | 0.754 |
ROCK1 |
0.785 | 0.091 | -3 | 0.753 |
EPHA6 |
0.785 | 0.023 | -1 | 0.894 |
OSR1 |
0.783 | 0.024 | 2 | 0.777 |
PBK |
0.783 | -0.020 | 1 | 0.741 |
LIMK1_TYR |
0.782 | -0.100 | 2 | 0.850 |
CRIK |
0.781 | 0.066 | -3 | 0.700 |
TTK |
0.781 | 0.032 | -2 | 0.828 |
ALPHAK3 |
0.781 | 0.044 | -1 | 0.814 |
MYO3A |
0.781 | 0.096 | 1 | 0.802 |
RIPK2 |
0.780 | -0.240 | 1 | 0.729 |
BIKE |
0.779 | 0.041 | 1 | 0.716 |
RET |
0.779 | -0.120 | 1 | 0.780 |
MEK2 |
0.779 | -0.261 | 2 | 0.781 |
MYO3B |
0.779 | 0.050 | 2 | 0.820 |
TYK2 |
0.778 | -0.126 | 1 | 0.777 |
YANK3 |
0.776 | -0.029 | 2 | 0.436 |
PKG1 |
0.775 | 0.017 | -2 | 0.696 |
TXK |
0.775 | 0.053 | 1 | 0.780 |
MST1R |
0.774 | -0.175 | 3 | 0.715 |
WEE1_TYR |
0.774 | 0.041 | -1 | 0.790 |
DDR1 |
0.774 | -0.175 | 4 | 0.782 |
YES1 |
0.774 | -0.033 | -1 | 0.867 |
TAO1 |
0.774 | -0.010 | 1 | 0.725 |
EPHB4 |
0.773 | -0.106 | -1 | 0.868 |
EPHA4 |
0.773 | -0.039 | 2 | 0.800 |
ABL2 |
0.773 | -0.036 | -1 | 0.848 |
FGR |
0.772 | -0.083 | 1 | 0.793 |
TYRO3 |
0.772 | -0.174 | 3 | 0.715 |
ROS1 |
0.771 | -0.149 | 3 | 0.679 |
JAK2 |
0.771 | -0.168 | 1 | 0.771 |
CSF1R |
0.771 | -0.121 | 3 | 0.688 |
LCK |
0.771 | 0.039 | -1 | 0.867 |
FER |
0.771 | -0.119 | 1 | 0.799 |
JAK3 |
0.770 | -0.115 | 1 | 0.748 |
ASK1 |
0.770 | -0.137 | 1 | 0.740 |
INSRR |
0.770 | -0.088 | 3 | 0.651 |
FLT3 |
0.769 | -0.088 | 3 | 0.705 |
BLK |
0.769 | 0.044 | -1 | 0.865 |
HCK |
0.768 | -0.064 | -1 | 0.859 |
SRMS |
0.767 | -0.100 | 1 | 0.791 |
NEK10_TYR |
0.767 | -0.100 | 1 | 0.672 |
FGFR2 |
0.767 | -0.149 | 3 | 0.695 |
ABL1 |
0.767 | -0.085 | -1 | 0.842 |
ITK |
0.766 | -0.071 | -1 | 0.836 |
FYN |
0.766 | 0.051 | -1 | 0.845 |
KIT |
0.766 | -0.113 | 3 | 0.695 |
CK1A |
0.766 | 0.011 | -3 | 0.450 |
KDR |
0.766 | -0.097 | 3 | 0.650 |
NEK3 |
0.765 | -0.234 | 1 | 0.736 |
EPHB1 |
0.765 | -0.128 | 1 | 0.785 |
FLT1 |
0.765 | -0.049 | -1 | 0.879 |
PDGFRB |
0.765 | -0.181 | 3 | 0.713 |
TNNI3K_TYR |
0.764 | -0.058 | 1 | 0.782 |
TEC |
0.763 | -0.055 | -1 | 0.772 |
JAK1 |
0.762 | -0.091 | 1 | 0.736 |
AAK1 |
0.762 | 0.070 | 1 | 0.620 |
EPHB2 |
0.762 | -0.109 | -1 | 0.852 |
BTK |
0.762 | -0.149 | -1 | 0.798 |
EPHB3 |
0.761 | -0.138 | -1 | 0.854 |
BMX |
0.761 | -0.061 | -1 | 0.757 |
TNK2 |
0.760 | -0.186 | 3 | 0.638 |
TNK1 |
0.760 | -0.155 | 3 | 0.691 |
ERBB2 |
0.759 | -0.127 | 1 | 0.737 |
TEK |
0.759 | -0.208 | 3 | 0.637 |
FGFR1 |
0.759 | -0.205 | 3 | 0.661 |
PTK6 |
0.758 | -0.187 | -1 | 0.782 |
EPHA3 |
0.758 | -0.142 | 2 | 0.773 |
EPHA7 |
0.758 | -0.103 | 2 | 0.792 |
MET |
0.757 | -0.130 | 3 | 0.670 |
FGFR3 |
0.757 | -0.137 | 3 | 0.666 |
FRK |
0.757 | -0.069 | -1 | 0.870 |
PTK2 |
0.756 | 0.044 | -1 | 0.823 |
LYN |
0.756 | -0.063 | 3 | 0.647 |
MERTK |
0.756 | -0.168 | 3 | 0.657 |
PDGFRA |
0.756 | -0.266 | 3 | 0.718 |
FLT4 |
0.755 | -0.169 | 3 | 0.661 |
AXL |
0.755 | -0.217 | 3 | 0.659 |
LTK |
0.755 | -0.165 | 3 | 0.647 |
ALK |
0.754 | -0.187 | 3 | 0.623 |
CK1G3 |
0.754 | 0.025 | -3 | 0.405 |
NTRK1 |
0.754 | -0.226 | -1 | 0.846 |
MATK |
0.754 | -0.090 | -1 | 0.787 |
EGFR |
0.753 | -0.057 | 1 | 0.645 |
STLK3 |
0.753 | -0.211 | 1 | 0.731 |
SYK |
0.753 | 0.041 | -1 | 0.818 |
EPHA5 |
0.753 | -0.079 | 2 | 0.788 |
EPHA8 |
0.752 | -0.067 | -1 | 0.848 |
DDR2 |
0.751 | -0.096 | 3 | 0.639 |
SRC |
0.751 | -0.062 | -1 | 0.842 |
INSR |
0.751 | -0.186 | 3 | 0.635 |
NTRK2 |
0.750 | -0.232 | 3 | 0.652 |
EPHA1 |
0.750 | -0.192 | 3 | 0.640 |
CSK |
0.749 | -0.123 | 2 | 0.793 |
PTK2B |
0.749 | -0.122 | -1 | 0.809 |
FGFR4 |
0.747 | -0.087 | -1 | 0.815 |
NTRK3 |
0.746 | -0.184 | -1 | 0.802 |
YANK2 |
0.744 | -0.051 | 2 | 0.454 |
ERBB4 |
0.740 | -0.050 | 1 | 0.669 |
EPHA2 |
0.739 | -0.099 | -1 | 0.814 |
MUSK |
0.739 | -0.147 | 1 | 0.638 |
IGF1R |
0.739 | -0.137 | 3 | 0.581 |
CK1G2 |
0.734 | 0.010 | -3 | 0.500 |
ZAP70 |
0.720 | -0.048 | -1 | 0.738 |
FES |
0.720 | -0.195 | -1 | 0.745 |