Motif 1137 (n=270)

Position-wise Probabilities
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uniprot genes site source protein function
A1IGU5 ARHGEF37 S665 ochoa Rho guanine nucleotide exchange factor 37 May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
A5A3E0 POTEF S1065 ochoa POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) None
A5YM69 ARHGEF35 S474 ochoa Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) None
A6NDE4 RBMY1B S486 ochoa RNA-binding motif protein, Y chromosome, family 1 member B RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
A6NEQ0 RBMY1E S486 ochoa RNA-binding motif protein, Y chromosome, family 1 member E RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
A6NM28 ZFP92 S405 ochoa Zinc finger protein 92 homolog (Zfp-92) KRAB domain-containing zinc-finger protein that represses B1/Alu SINE transposable elements and modulates the transcription of nearby genes in a tissue-specific manner. It regulates glucose homeostasis and lipid metabolism by modulating the expression of the endocrine cell-defining transcription factor, MAFB, in pancreatic islets and, the fat metabolism regulator, ACACB, in adipose tissue and muscle. {ECO:0000250|UniProtKB:Q62396}.
A6NM28 ZFP92 T406 ochoa Zinc finger protein 92 homolog (Zfp-92) KRAB domain-containing zinc-finger protein that represses B1/Alu SINE transposable elements and modulates the transcription of nearby genes in a tissue-specific manner. It regulates glucose homeostasis and lipid metabolism by modulating the expression of the endocrine cell-defining transcription factor, MAFB, in pancreatic islets and, the fat metabolism regulator, ACACB, in adipose tissue and muscle. {ECO:0000250|UniProtKB:Q62396}.
A8MVS5 HIDE1 T220 ochoa Protein HIDE1 None
H3BTX0 None S72 ochoa PAXIP1-associated glutamate-rich protein 1 None
J3KQ70 INO80B-WBP1 S351 ochoa HCG2039827, isoform CRA_e (INO80B-WBP1 readthrough (NMD candidate)) None
O14646 CHD1 T1700 ochoa Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1) ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:P40201, ECO:0000269|PubMed:18042460, ECO:0000269|PubMed:28866611}.
O14681 EI24 S330 ochoa Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}.
O14879 IFIT3 S478 ochoa Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}.
O15156 ZBTB7B T529 ochoa Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK) Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity). {ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}.
O15198 SMAD9 S458 ochoa Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
O15534 PER1 S1279 ochoa Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}.
O43353 RIPK2 S529 ochoa Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (PubMed:14638696, PubMed:17054981, PubMed:21123652, PubMed:28656966, PubMed:9575181, PubMed:9642260). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17054981, PubMed:17562858, PubMed:21123652, PubMed:22607974, PubMed:28656966, PubMed:29452636, PubMed:30026309). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:22607974, PubMed:28545134, PubMed:29452636, PubMed:30026309, PubMed:30279485, PubMed:30478312). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (PubMed:17562858, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:18079694). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18079694). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (PubMed:29452636, PubMed:30026309). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (PubMed:21887730). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181). {ECO:0000269|PubMed:14638696, ECO:0000269|PubMed:17054981, ECO:0000269|PubMed:17562858, ECO:0000269|PubMed:18079694, ECO:0000269|PubMed:21123652, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:26646181, ECO:0000269|PubMed:28545134, ECO:0000269|PubMed:28656966, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:30279485, ECO:0000269|PubMed:30478312, ECO:0000269|PubMed:9575181, ECO:0000269|PubMed:9642260}.
O43426 SYNJ1 S1562 ochoa Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:23804563, PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:Q62910, ECO:0000269|PubMed:23804563, ECO:0000269|PubMed:27435091}.
O43439 CBFA2T2 T592 ochoa Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.
O43765 SGTA T303 ochoa Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP) Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}.
O43896 KIF1C S1092 ochoa Kinesin-like protein KIF1C Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:9685376}.
O60341 KDM1A T841 ochoa Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:16079795, PubMed:16140033, PubMed:16223729, PubMed:27292636). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412). May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16079794, PubMed:16140033, PubMed:16885027, PubMed:21300290, PubMed:23721412). Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795). Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1 (PubMed:29691401). Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2 (PubMed:29358331). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:16079794, PubMed:16140033). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20562920, PubMed:27292636). Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281). Required for the repression of GIPR expression (PubMed:34655521, PubMed:34906447). {ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:15620353, ECO:0000269|PubMed:15811342, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:16140033, ECO:0000269|PubMed:16223729, ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:29358331, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:34655521, ECO:0000269|PubMed:34906447}.
O60825 PFKFB2 S493 ochoa 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}.
O75044 SRGAP2 S1061 ochoa SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}.
O75436 VPS26A S315 ochoa Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}.
O75459 PAGE1 T136 ochoa P antigen family member 1 (PAGE-1) (AL5) (G antigen 9) (GAGE-9) (G antigen family B member 1) (Prostate-associated gene 1 protein) None
O75469 NR1I2 T422 psp Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
O75808 CAPN15 T1074 ochoa Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) None
O95136 S1PR2 S343 ochoa Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5) Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:P47752, ECO:0000269|PubMed:10617617, ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:29453251}.
O95149 SNUPN S350 ochoa Snurportin-1 (RNA U transporter 1) Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}.
O95235 KIF20A S878 ochoa|psp Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. {ECO:0000269|PubMed:12939256}.
O95453 PARN S628 ochoa Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417). {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15175153, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:9736620}.
O95817 BAG3 S564 ochoa BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}.
O96020 CCNE2 T392 ochoa|psp G1/S-specific cyclin-E2 Essential for the control of the cell cycle at the late G1 and early S phase. {ECO:0000269|PubMed:9840927, ECO:0000269|PubMed:9840943, ECO:0000269|PubMed:9858585}.
P01834 IGKC S96 ochoa Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI) Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
P02545 LMNA S652 ochoa|psp Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P05362 ICAM1 T521 ochoa Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}.
P05423 POLR3D S386 ochoa DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3E/RPC5 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P25441, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}.
P08579 SNRPB2 T213 ochoa U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'') Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}.
P09917 ALOX5 S664 psp Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34) Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:19022417, PubMed:21233389, PubMed:22516296, PubMed:23246375, PubMed:24282679, PubMed:24893149, PubMed:31664810, PubMed:8615788, PubMed:8631361). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:17114001, PubMed:21206090, PubMed:31664810, PubMed:32404334, PubMed:8615788). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P48999, ECO:0000269|PubMed:17114001, ECO:0000269|PubMed:19022417, ECO:0000269|PubMed:21200133, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0000269|PubMed:23246375, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24893149, ECO:0000269|PubMed:31664810, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8615788, ECO:0000269|PubMed:8631361}.
P0C7P1 RBMY1D S486 ochoa RNA-binding motif protein, Y chromosome, family 1 member D RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.
P0CG38 POTEI S1065 ochoa POTE ankyrin domain family member I None
P0CG39 POTEJ S1028 ochoa POTE ankyrin domain family member J None
P0DJD3 RBMY1A1 S486 ochoa RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY) RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:8269511}.
P0DJD4 RBMY1C S486 ochoa RNA-binding motif protein, Y chromosome, family 1 member C RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.
P11217 PYGM S831 ochoa Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis. {ECO:0000269|PubMed:8316268}.
P13807 GYS1 S727 ochoa|psp Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. {ECO:0000269|PubMed:35835870}.
P19419 ELK1 T417 psp ETS domain-containing protein Elk-1 Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:7889942). {ECO:0000269|PubMed:10799319, ECO:0000269|PubMed:1630903, ECO:0000269|PubMed:7889942}.
P20265 POU3F2 T432 ochoa POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7) Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). {ECO:0000250|UniProtKB:P31360, ECO:0000250|UniProtKB:P56222}.
P20700 LMNB1 T575 ochoa|psp Lamin-B1 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P22531 SPRR2E S60 ochoa Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II) Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
P22532 SPRR2D S60 ochoa Small proline-rich protein 2D (SPR-2D) (Small proline-rich protein II) (SPR-II) Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
P24864 CCNE1 S399 psp G1/S-specific cyclin-E1 Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.
P24928 POLR2A S1958 ochoa DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250|UniProtKB:G3MZY8, ECO:0000250|UniProtKB:P08775, ECO:0000269|PubMed:23748380, ECO:0000269|PubMed:24207025, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:28108474, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269|PubMed:18032511}.
P25686 DNAJB2 S313 ochoa DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:15936278, ECO:0000269|PubMed:20889486, ECO:0000269|PubMed:21625540, ECO:0000269|PubMed:21719532, ECO:0000269|PubMed:22219199, ECO:0000269|PubMed:22396390, ECO:0000269|PubMed:24023695, ECO:0000269|PubMed:7957263}.
P25787 PSMA2 T222 ochoa Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) (Proteasome subunit alpha-2) (alpha-2) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
P30530 AXL S884 ochoa Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. {ECO:0000269|PubMed:10403904, ECO:0000269|PubMed:11484958, ECO:0000269|PubMed:12364394, ECO:0000269|PubMed:12490074, ECO:0000269|PubMed:15507525, ECO:0000269|PubMed:15733062, ECO:0000269|PubMed:1656220, ECO:0000269|PubMed:18840707}.; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:25277499}.; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22673088}.; FUNCTION: (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210). {ECO:0000269|PubMed:28076778, ECO:0000269|PubMed:29379210, ECO:0000269|PubMed:31311882}.
P31350 RRM2 S377 ochoa Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
P32246 CCR1 S343 ochoa C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191) Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed:15905581). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4 (By similarity). Also mediates monocyte migration upon CXCL4 binding (PubMed:29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity). {ECO:0000250|UniProtKB:P51675, ECO:0000269|PubMed:14991608, ECO:0000269|PubMed:15905581, ECO:0000269|PubMed:29930254}.
P33897 ABCD1 S733 ochoa ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP) ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:29397936, PubMed:33500543). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:21145416, PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity). {ECO:0000250|UniProtKB:P48410, ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:15682271, ECO:0000269|PubMed:16946495, ECO:0000269|PubMed:18757502, ECO:0000269|PubMed:21145416, ECO:0000269|PubMed:23671276, ECO:0000269|PubMed:29397936, ECO:0000269|PubMed:33500543}.
P35326 SPRR2A S60 ochoa Small proline-rich protein 2A (SPR-2A) (2-1) Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (PubMed:34735226). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (By similarity). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (PubMed:8325635). {ECO:0000250|UniProtKB:P0DV37, ECO:0000269|PubMed:34735226, ECO:0000269|PubMed:8325635}.
P36873 PPP1CC T311 psp Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:17936702, PubMed:25012651). Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1 (PubMed:17936702). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (By similarity). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509). Dephosphorylates MKI67 at the onset of anaphase (PubMed:25012651). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:35831509). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509}.
P38432 COIL S566 ochoa Coilin (p80-coilin) Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}.
P40121 CAPG S337 ochoa Macrophage-capping protein (Actin regulatory protein CAP-G) Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
P41143 OPRD1 T361 ochoa|psp Delta-type opioid receptor (D-OR-1) (DOR-1) G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.
P41181 AQP2 S261 psp Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct) Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:15509592, PubMed:7510718, PubMed:7524315, PubMed:8140421, PubMed:8584435). Plays an essential role in renal water homeostasis (PubMed:15509592, PubMed:7524315, PubMed:8140421). Could also be permeable to glycerol (PubMed:8584435). {ECO:0000269|PubMed:15509592, ECO:0000269|PubMed:7510718, ECO:0000269|PubMed:7524315, ECO:0000269|PubMed:8140421, ECO:0000269|PubMed:8584435}.
P41970 ELK3 S396 ochoa ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2) May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
P46527 CDKN1B T187 psp Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}.
P49006 MARCKSL1 S184 ochoa MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}.
P49674 CSNK1E S405 ochoa|psp Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}.
P49711 CTCF T717 ochoa Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin (PubMed:18347100, PubMed:18654629, PubMed:19322193). Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina (PubMed:18347100, PubMed:18654629, PubMed:19322193). Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers (PubMed:18347100, PubMed:18654629, PubMed:19322193). Plays a critical role in the epigenetic regulation (PubMed:16949368). Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (PubMed:16107875, PubMed:16815976, PubMed:17827499). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (By similarity). Regulates asynchronous replication of IGF2/H19 (By similarity). Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones (PubMed:18413740). Inversely, binding to target sites is prevented by CpG methylation (PubMed:18413740). Plays an important role in chromatin remodeling (PubMed:18413740). Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (PubMed:12191639). Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription (PubMed:12191639). When bound to chromatin, it provides an anchor point for nucleosomes positioning (PubMed:12191639). Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation (PubMed:11743158). May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation (PubMed:11743158). Involved in sister chromatid cohesion (PubMed:12191639). Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites (PubMed:18550811). Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene (PubMed:18413740, PubMed:8649389, PubMed:9591631). Also binds to the PLK and PIM1 promoters (PubMed:12191639). Acts as a transcriptional activator of APP (PubMed:9407128). Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (PubMed:18347100, PubMed:19322193). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor (PubMed:12191639). {ECO:0000250|UniProtKB:Q61164, ECO:0000269|PubMed:11743158, ECO:0000269|PubMed:16107875, ECO:0000269|PubMed:16815976, ECO:0000269|PubMed:16949368, ECO:0000269|PubMed:17827499, ECO:0000269|PubMed:18347100, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18550811, ECO:0000269|PubMed:18654629, ECO:0000269|PubMed:19322193, ECO:0000269|PubMed:26321640, ECO:0000269|PubMed:8649389, ECO:0000269|PubMed:9407128, ECO:0000269|PubMed:9591631, ECO:0000303|PubMed:12191639}.
P49848 TAF6 S666 ochoa Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80) The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269|PubMed:11583621, ECO:0000269|PubMed:18628956, ECO:0000269|PubMed:20096117, ECO:0000269|PubMed:29358700}.
P51397 DAP S91 ochoa Death-associated protein 1 (DAP-1) Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849). {ECO:0000250|UniProtKB:Q9I9N1, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:7828849}.
P51784 USP11 S953 ochoa Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799, PubMed:28992046). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Promotes cell proliferation by deubiquitinating phosphorylated E2F1 (PubMed:28992046). {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889, ECO:0000269|PubMed:20233726, ECO:0000269|PubMed:24724799, ECO:0000269|PubMed:28992046}.
P52569 SLC7A2 S647 ochoa Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2) Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). {ECO:0000250|UniProtKB:P18581, ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2. {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269|PubMed:28684763, ECO:0000269|PubMed:9174363}.
P52945 PDX1 S273 ochoa Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
P53367 ARFIP1 T361 ochoa Arfaptin-1 (ADP-ribosylation factor-interacting protein 1) Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:22981988, PubMed:9038142). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:9038142}.
P54760 EPHB4 T976 ochoa Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}.
P55809 OXCT1 S509 ochoa Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase) Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (PubMed:10964512). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250|UniProtKB:Q29551, ECO:0000269|PubMed:10964512}.
P56377 AP1S2 T146 ochoa AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
P56748 CLDN8 S215 ochoa Claudin-8 Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). Cannot form tight junction strands on its own (PubMed:36008380). {ECO:0000250|UniProtKB:Q9Z260, ECO:0000269|PubMed:36008380}.
P60709 ACTB S365 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P61966 AP1S1 S147 ochoa AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:9733768}.
P62136 PPP1CA T320 ochoa|psp Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets (PubMed:28216226, PubMed:30158517, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39603239, PubMed:39603240). Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (PubMed:17283141). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:21712997). May dephosphorylate CSNK1D and CSNK1E (PubMed:21712997). Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response (PubMed:23499489). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000250|UniProtKB:P62137, ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23499489, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35830882, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}.; FUNCTION: (Microbial infection) Necessary for alphaviruses replication. {ECO:0000269|PubMed:29769351}.
P62140 PPP1CB T316 ochoa Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}.
P62324 BTG1 S159 ochoa|psp Protein BTG1 (B-cell translocation gene 1 protein) Anti-proliferative protein. {ECO:0000269|PubMed:1373383}.
P63261 ACTG1 S365 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P78543 BTG2 S147 ochoa Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3) Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}.
P84022 SMAD3 S416 ochoa|psp Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:15588252, ECO:0000269|PubMed:16156666, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19218245, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9732876, ECO:0000269|PubMed:9892009}.
P84095 RHOG T180 ochoa Rho-related GTP-binding protein RhoG Plays a role in immunological synaptic F-actin density and architecture organization (PubMed:33513601). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (PubMed:33513601). Required for the formation of membrane ruffles during macropinocytosis (PubMed:15133129). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (PubMed:17875742). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (PubMed:33513601). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (PubMed:33513601). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (PubMed:33513601). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (PubMed:33513601). {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:33513601}.; FUNCTION: (Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:17074883}.
Q02446 SP4 T774 ochoa Transcription factor Sp4 (SPR-1) Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Q06455 RUNX1T1 T592 ochoa Protein CBFA2T1 (Cyclin-D-related protein) (Eight twenty one protein) (Protein ETO) (Protein MTG8) (Zinc finger MYND domain-containing protein 2) Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:10688654, PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.
Q07955 SRSF1 S238 psp Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.
Q12968 NFATC3 S1063 ochoa Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}.
Q13098 GPS1 T479 ochoa|psp COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH) Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
Q13105 ZBTB17 S792 ochoa Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60) Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). {ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764, ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237, ECO:0000269|PubMed:9312026}.
Q13242 SRSF9 S211 ochoa Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}.
Q13496 MTM1 S591 ochoa Myotubularin (EC 3.1.3.95) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Phosphatidylinositol-3-phosphate phosphatase) Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PubMed:10900271, PubMed:11001925, PubMed:12646134, PubMed:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508). Plays a role in mitochondrial morphology and positioning (PubMed:21135508). Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870). {ECO:0000269|PubMed:10900271, ECO:0000269|PubMed:11001925, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:14722070, ECO:0000269|PubMed:21135508, ECO:0000269|PubMed:23818870, ECO:0000269|PubMed:9537414}.
Q13613 MTMR1 S653 ochoa Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate, generating phosphatidylinositol (PubMed:11733541, PubMed:27018598). Could also dephosphorylate phosphatidylinositol 3,5-bisphosphate to produce phosphatidylinositol 5-phosphate (PubMed:27018598). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:27018598}.
Q13614 MTMR2 S631 ochoa|psp Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 (EC 3.1.3.95) (Myotubularin-related protein 2) (Phosphatidylinositol-3-phosphate phosphatase) Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11733541, PubMed:12668758, PubMed:14690594, PubMed:21372139). Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation (PubMed:35580604). {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:14690594, ECO:0000269|PubMed:21372139, ECO:0000269|PubMed:35580604}.
Q14094 CCNI S366 ochoa Cyclin-I None
Q14118 DAG1 T884 ochoa Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}.
Q14774 HLX S477 ochoa H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1) Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). {ECO:0000250}.
Q14781 CBX2 S520 ochoa Chromobox protein homolog 2 Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). {ECO:0000250|UniProtKB:P30658, ECO:0000269|PubMed:19361780, ECO:0000269|PubMed:21282530}.
Q14802 FXYD3 T76 ochoa FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3) Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534, ECO:0000269|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.
Q15025 TNIP1 S627 ochoa TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}.
Q15311 RALBP1 S645 ochoa RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277). {ECO:0000269|PubMed:10910768, ECO:0000269|PubMed:12775724, ECO:0000269|PubMed:21822277, ECO:0000269|PubMed:7673236}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000269|PubMed:10924126, ECO:0000269|PubMed:11300797, ECO:0000269|PubMed:11437348, ECO:0000269|PubMed:9548755}.
Q15415 RBMY1F S486 ochoa RNA-binding motif protein, Y chromosome, family 1 member F/J (Y chromosome RNA recognition motif 2) RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. {ECO:0000269|PubMed:8269511}.
Q15743 GPR68 S353 ochoa G-protein coupled receptor 68 (G-protein coupled receptor 12A) (GPR12A) (Ovarian cancer G-protein coupled receptor 1) (OGR-1) Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed:33478938, PubMed:39753132). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:29677517, PubMed:39753132). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:29677517, PubMed:39753132). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed:29677517, PubMed:30471999). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed:29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity). {ECO:0000250|UniProtKB:Q8BFQ3, ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:29677517, ECO:0000269|PubMed:30471999, ECO:0000269|PubMed:32865988, ECO:0000269|PubMed:33478938, ECO:0000269|PubMed:39753132}.
Q15762 CD226 Y325 psp CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226) Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:9712030). Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:26755705, PubMed:31253644, PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity). {ECO:0000250|UniProtKB:Q8K4F0, ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:30591568, ECO:0000269|PubMed:31253644, ECO:0000269|PubMed:8673704, ECO:0000269|PubMed:9712030}.
Q15773 MLF2 S238 ochoa Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2) None
Q15796 SMAD2 S458 ochoa Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209). {ECO:0000250|UniProtKB:Q62432, ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:9892009}.
Q15797 SMAD1 S456 ochoa Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}.
Q15834 CCDC85B S190 ochoa Coiled-coil domain-containing protein 85B (Hepatitis delta antigen-interacting protein A) (Delta-interacting protein A) Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). {ECO:0000250|UniProtKB:A2CEM9, ECO:0000250|UniProtKB:Q6PDY0, ECO:0000269|PubMed:17014843, ECO:0000269|PubMed:17873903}.; FUNCTION: (Microbial infection) Plays a role in hepatitis delta virus (HDV) genomic replication. {ECO:0000269|PubMed:8810253}.
Q2M1P5 KIF7 S1332 ochoa Kinesin-like protein KIF7 Essential for hedgehog signaling regulation: acts both as a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). {ECO:0000250|UniProtKB:B7ZNG0, ECO:0000269|PubMed:21633164}.
Q32M88 PGGHG S725 ochoa Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1) Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins. {ECO:0000269|PubMed:26682924}.
Q32P44 EML3 T885 ochoa Echinoderm microtubule-associated protein-like 3 (EMAP-3) Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}.
Q3B726 POLR1F S328 ochoa DNA-directed RNA polymerase I subunit RPA43 (DNA-directed RNA polymerase I subunit F) (Twist neighbor protein) Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.
Q3YBM2 TMEM176B S258 ochoa Transmembrane protein 176B (Protein LR8) May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). {ECO:0000250}.
Q3YBR2 TBRG1 S400 ochoa Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2) Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269|PubMed:17110379}.
Q4G0F5 VPS26B T325 ochoa Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity). {ECO:0000250|UniProtKB:O75436, ECO:0000250|UniProtKB:Q8C0E2}.
Q53GA4 PHLDA2 S141 ochoa Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C) Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}.
Q53LP3 SOWAHC S513 ochoa Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) None
Q5BJF6 ODF2 S820 ochoa Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly. {ECO:0000269|PubMed:16966375}.
Q5JR59 MTUS2 S1360 ochoa Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip. {ECO:0000269|PubMed:19543227}.
Q5SYE7 NHSL1 S1599 ochoa NHS-like protein 1 None
Q5T0B9 ZNF362 S410 ochoa Zinc finger protein 362 May be involved in transcriptional regulation.
Q5VYV7 SLX4IP S396 ochoa Protein SLX4IP (SLX4-interacting protein) None
Q5XXA6 ANO1 S974 ochoa Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity). {ECO:0000250|UniProtKB:Q8BHY3, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:28963502, ECO:0000269|PubMed:31732694, ECO:0000269|PubMed:32487539, ECO:0000269|PubMed:33026825, ECO:0000269|PubMed:37253099}.; FUNCTION: [Isoform 4]: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. {ECO:0000269|PubMed:25220078}.; FUNCTION: [Isoform 5]: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+). {ECO:0000269|PubMed:26359375}.
Q658Y4 FAM91A1 S826 ochoa Protein FAM91A1 As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269|PubMed:29426865}.
Q66GS9 CEP135 S1130 ochoa Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4) Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). {ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962, ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27477386}.
Q6DN14 MCTP1 S989 ochoa Multiple C2 and transmembrane domain-containing protein 1 Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. {ECO:0000250|UniProtKB:A1ZBD6}.
Q6DT37 CDC42BPG S1540 ochoa Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}.
Q6F5E8 CARMIL2 S1423 ochoa Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein) Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26466680, PubMed:26578515). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26466680, PubMed:26578515). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647348, PubMed:27647349, PubMed:28112205). {ECO:0000269|PubMed:19846667, ECO:0000269|PubMed:26466680, ECO:0000269|PubMed:26578515, ECO:0000269|PubMed:27647348, ECO:0000269|PubMed:27647349, ECO:0000269|PubMed:28112205}.
Q6N075 MFSD5 S440 ochoa Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2) Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. {ECO:0000269|PubMed:21464289}.
Q6P6C2 ALKBH5 S384 ochoa RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) Dioxygenase that specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178, PubMed:34048572, PubMed:36944332, PubMed:37257451, PubMed:37369679). Demethylates RNA by oxidative demethylation, which requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing, translation and export (PubMed:23177736, PubMed:34048572, PubMed:36944332, PubMed:37257451). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity). Involved in paraspeckle assembly, a nuclear membraneless organelle, by undergoing liquid-liquid phase separation (PubMed:37369679, PubMed:37474102). Paraspeckle assembly is coupled with m6A demethylation of RNAs, such as NEAT1 non-coding RNA (PubMed:37474102). Also acts as a negative regulator of T-cell development: inhibits gamma-delta T-cell proliferation via demethylation of JAG1 and NOTCH2 transcripts (By similarity). Inhibits regulatory T-cell (Treg) recruitment by mediating demethylation and destabilization of CCL28 mRNAs (By similarity). {ECO:0000250|UniProtKB:Q3TSG4, ECO:0000269|PubMed:21264265, ECO:0000269|PubMed:23177736, ECO:0000269|PubMed:24489119, ECO:0000269|PubMed:24616105, ECO:0000269|PubMed:24778178, ECO:0000269|PubMed:34048572, ECO:0000269|PubMed:36944332, ECO:0000269|PubMed:37257451, ECO:0000269|PubMed:37369679, ECO:0000269|PubMed:37474102}.
Q6P9B9 INTS5 S1010 ochoa Integrator complex subunit 5 (Int5) Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}.
Q6PID6 TTC33 T251 ochoa Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor) None
Q6S8J3 POTEE S1065 ochoa POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) None
Q6T4R5 NHS S1640 ochoa Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}.
Q6U7Q0 ZNF322 S391 psp Zinc finger protein 322 (Zinc finger protein 322A) (Zinc finger protein 388) (Zinc finger protein 489) Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZ89, ECO:0000269|PubMed:15555580}.
Q6ZRI6 C15orf39 S1034 ochoa Uncharacterized protein C15orf39 None
Q6ZUK4 TMEM26 S357 ochoa Transmembrane protein 26 None
Q7L5D6 GET4 S317 ochoa Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). {ECO:0000269|PubMed:20676083, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:21743475, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:28104892, ECO:0000269|PubMed:32395830}.
Q7Z406 MYH14 S1983 ochoa Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.
Q7Z494 NPHP3 S1320 ochoa Nephrocystin-3 Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. {ECO:0000269|PubMed:18371931}.
Q86U70 LDB1 S400 ochoa LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor) Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}.
Q86W92 PPFIBP1 S999 ochoa Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2) May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.
Q86XT2 VPS37D S240 ochoa Vacuolar protein sorting-associated protein 37D (ESCRT-I complex subunit VPS37D) (Williams-Beuren syndrome chromosomal region 24 protein) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Q86YQ8 CPNE8 T554 ochoa Copine-8 (Copine VIII) Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. {ECO:0000250|UniProtKB:Q99829}.
Q86YV9 HPS6 T766 ochoa BLOC-2 complex member HPS6 (Hermansky-Pudlak syndrome 6 protein) (Ruby-eye protein homolog) (Ru) May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (PubMed:17041891). Acts as a cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619). {ECO:0000269|PubMed:17041891, ECO:0000269|PubMed:25189619}.
Q86Z02 HIPK1 S1200 ochoa Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}.
Q8IUC4 RHPN2 S674 ochoa Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE) Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}.
Q8IUH3 RBM45 S464 ochoa RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) RNA-binding protein with binding specificity for poly(C). May play an important role in neural development. {ECO:0000250|UniProtKB:Q8CFD1, ECO:0000269|PubMed:12220514}.
Q8IUW5 RELL1 T261 ochoa RELT-like protein 1 Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}.
Q8IXM2 BACC1 T161 ochoa BPTF-associated chromatin complex component 1 (BPTF-associated protein of 18 kDa) (Chromatin complexes subunit BAP18) Component of chromatin complexes such as the MLL1/MLL and NURF complexes.
Q8IZA0 KIAA0319L T1037 ochoa Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR) Possible role in axon guidance through interaction with RTN4R. {ECO:0000269|PubMed:20697954}.; FUNCTION: (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. {ECO:0000269|PubMed:26814968}.
Q8N0S2 SYCE1 S340 ochoa Synaptonemal complex central element protein 1 (Cancer/testis antigen 76) (CT76) Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. {ECO:0000250|UniProtKB:Q9D495}.
Q8N6L1 KRTCAP2 T124 ochoa Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 (Oligosaccharyl transferase subunit KCP2) (Keratinocyte-associated protein 2) (KCP-2) Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853, PubMed:28860277). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:22467853, PubMed:28860277). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex (PubMed:28860277). May be involved in N-glycosylation of APP (amyloid-beta precursor protein) (PubMed:21768116). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116). {ECO:0000269|PubMed:21768116, ECO:0000269|PubMed:22467853, ECO:0000269|PubMed:28860277}.
Q8NBJ5 COLGALT1 S612 ochoa Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (ColGalT 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1) Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). Also involved in the biosynthesis of collagen type IV (PubMed:30412317). {ECO:0000269|PubMed:19075007, ECO:0000269|PubMed:22216269, ECO:0000269|PubMed:27402836, ECO:0000269|PubMed:30412317}.
Q8NC74 RBBP8NL S653 ochoa RBBP8 N-terminal-like protein None
Q8NE79 POPDC1 S350 ochoa Popeye domain-containing protein 1 (Popeye protein 1) Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. {ECO:0000250|UniProtKB:Q5PQZ7, ECO:0000250|UniProtKB:Q9ES83, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:26642364}.
Q8NFJ5 GPRC5A S345 ochoa Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). {ECO:0000250|UniProtKB:Q8BHL4, ECO:0000269|PubMed:18000218}.
Q8NFY4 SEMA6D T1062 ochoa Semaphorin-6D Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}.
Q8TBC3 SHKBP1 T696 ochoa SH3KBP1-binding protein 1 (SETA-binding protein 1) Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}.
Q8TCB7 METTL6 S274 ochoa tRNA N(3)-cytidine methyltransferase METTL6 (EC 2.1.1.-) (Methyltransferase-like protein 6) (hMETTL6) S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34268557, PubMed:34862464, PubMed:34922197). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (PubMed:34268557). {ECO:0000269|PubMed:32923617, ECO:0000269|PubMed:34268557, ECO:0000269|PubMed:34862464, ECO:0000269|PubMed:34922197}.
Q8WUA4 GTF3C2 S901 ochoa General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.
Q8WUX9 CHMP7 S441 ochoa|psp Charged multivesicular body protein 7 (Chromatin-modifying protein 7) ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
Q8WVB3 HEXD S477 ochoa Hexosaminidase D (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase D) (Hexosaminidase domain-containing protein) (N-acetyl-beta-galactosaminidase) Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221). {ECO:0000269|PubMed:19040401, ECO:0000269|PubMed:23099419, ECO:0000269|PubMed:27149221}.
Q8WVN6 SECTM1 S237 ochoa Secreted and transmembrane protein 1 (Protein K-12) May be involved in thymocyte signaling. {ECO:0000269|PubMed:15742156}.
Q8WWM9 CYGB T180 ochoa Cytoglobin (Histoglobin) (HGb) (Nitric oxygen dioxygenase CYGB) (NOD) (EC 1.14.12.-) (Nitrite reductase CYGB) (EC 1.7.-.-) (Pseudoperoxidase CYGB) (EC 1.11.1.-) (Stellate cell activation-associated protein) (Superoxide dismutase CYGB) (EC 1.15.1.1) Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:11893755, PubMed:12359339, PubMed:15165856, PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819, PubMed:29128400, PubMed:33576020, PubMed:34930834). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone (PubMed:19147491, PubMed:28393874). Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide (PubMed:29128400). Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress (PubMed:12359339, PubMed:33576020, PubMed:34930834). Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier (PubMed:11893755, PubMed:15299006, PubMed:20553503). {ECO:0000269|PubMed:11893755, ECO:0000269|PubMed:12359339, ECO:0000269|PubMed:15165856, ECO:0000269|PubMed:15299006, ECO:0000269|PubMed:19147491, ECO:0000269|PubMed:20511233, ECO:0000269|PubMed:20553503, ECO:0000269|PubMed:28393874, ECO:0000269|PubMed:28671819, ECO:0000269|PubMed:29128400, ECO:0000269|PubMed:33576020, ECO:0000269|PubMed:34930834}.
Q8WWN9 IPCEF1 S427 ochoa Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. {ECO:0000250}.
Q92928 RAB1C T191 ochoa Putative Ras-related protein Rab-1C (hRab1c) (EC 3.6.5.2) Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250|UniProtKB:P62820}.
Q92963 RIT1 S209 psp GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1) Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. {ECO:0000269|PubMed:15632082, ECO:0000269|PubMed:23791108}.
Q96A00 PPP1R14A S136 ochoa Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17) Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Q96A29 SLC35C1 S353 ochoa GDP-fucose transporter 1 (Solute carrier family 35 member C1) Antiporter specific for GDP-l-fucose and depending on the concomitant reverse transport of GMP. Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. {ECO:0000269|PubMed:11326279, ECO:0000269|PubMed:11326280, ECO:0000269|PubMed:27738779}.
Q96E09 PABIR1 S276 ochoa PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (PABIR family member 1) Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}.
Q96FH0 BORCS8 S109 ochoa BLOC-1-related complex subunit 8 (MEF2B neighbor) As part of the BLOC-one-related complex (BORC), it plays a role in the movement and localization of lysosomes at the cell periphery (PubMed:25898167, PubMed:38128568). Associated with the cytosolic face of lysosomes, BORC recruits ARL8B to the lysosomal membrane and couples lysosomes to microtubule plus-end-directed kinesin motors, driving lysosome movement toward the cell periphery. {ECO:0000269|PubMed:38128568, ECO:0000305|PubMed:25898167}.
Q96H79 ZC3HAV1L S289 ochoa Zinc finger CCCH-type antiviral protein 1-like None
Q96IG2 FBXL20 S425 ochoa|psp F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.
Q96N77 ZNF641 S426 ochoa Zinc finger protein 641 Transcriptional activator. Activates transcriptional activities of SRE and AP-1. {ECO:0000269|PubMed:16343441}.
Q96Q07 BTBD9 S599 ochoa BTB/POZ domain-containing protein 9 None
Q96RM1 SPRR2F S60 ochoa Small proline-rich protein 2F (SPR-2F) Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
Q96S21 RAB40C S268 ochoa Ras-related protein Rab-40C (EC 3.6.5.2) (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3) RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:29156729, ECO:0000269|PubMed:35512830}.
Q96T17 MAP7D2 S721 ochoa MAP7 domain-containing protein 2 Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}.
Q99576 TSC22D3 S122 ochoa TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7, ECO:0000269|PubMed:11468175, ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:15031210}.; FUNCTION: [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000250|UniProtKB:Q9Z2S7}.
Q99638 RAD9A S380 ochoa|psp Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044). {ECO:0000269|PubMed:10713044, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:31135337}.
Q99743 NPAS2 S812 ochoa Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4) Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability. Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes. Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (By similarity). Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (By similarity). {ECO:0000250|UniProtKB:P97460, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:11441147, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18439826, ECO:0000269|PubMed:18819933}.
Q99956 DUSP9 T372 ochoa Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) Inactivates MAP kinases. Has a specificity for the ERK family.
Q9BQ15 NABP2 S200 ochoa SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501, ECO:0000269|PubMed:25249620}.
Q9BT09 CNPY3 S268 ochoa Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein) Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). {ECO:0000250}.
Q9BTK6 PAGR1 S242 ochoa PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}.
Q9BU19 ZNF692 S509 ochoa Zinc finger protein 692 (AICAR responsive element binding protein) May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}.
Q9BWG4 SSBP4 S374 ochoa Single-stranded DNA-binding protein 4 None
Q9BX63 BRIP1 S1237 ochoa Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}.
Q9BYX7 POTEKP S365 ochoa Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K) None
Q9GZU3 TMEM39B S482 ochoa Transmembrane protein 39B May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase. {ECO:0000250|UniProtKB:Q7ZW11}.
Q9H0U4 RAB1B T191 ochoa Ras-related protein Rab-1B (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}.
Q9H2G2 SLK Y1225 ochoa STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.
Q9H2V7 SPNS1 S518 ochoa Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1) Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949, PubMed:37075117). Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949, PubMed:37075117). Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin (PubMed:36161949). Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively (PubMed:36161949, PubMed:37075117). Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMed:36161949). Lysosomal LPC could function as intracellular signaling messenger (PubMed:37075117). Essential player in lysosomal homeostasis (PubMed:36161949). Crucial for cell survival under conditions of nutrient limitation (PubMed:37075117). May be involved in necrotic or autophagic cell death (PubMed:12815463). {ECO:0000269|PubMed:12815463, ECO:0000269|PubMed:36161949, ECO:0000269|PubMed:37075117, ECO:0000303|PubMed:37075117}.
Q9H3H1 TRIT1 S455 ochoa tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase) Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:11111046, PubMed:24126054, PubMed:24901367, PubMed:34774131). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (PubMed:24126054). TRIT1 is therefore required for selenoprotein expression (PubMed:24126054). {ECO:0000269|PubMed:11111046, ECO:0000269|PubMed:24126054, ECO:0000269|PubMed:24901367, ECO:0000269|PubMed:34774131}.
Q9H4G0 EPB41L1 S870 ochoa Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9H4I2 ZHX3 S946 ochoa Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}.
Q9H6A9 PCNX3 S2023 ochoa Pecanex-like protein 3 (Pecanex homolog protein 3) None
Q9H6U6 BCAS3 S917 ochoa BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}.
Q9H6Y7 RNF167 S341 ochoa E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:33594058, PubMed:35114100). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058). Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562). Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289). Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617). Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890). Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481). Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844). Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289). {ECO:0000269|PubMed:16314844, ECO:0000269|PubMed:23129617, ECO:0000269|PubMed:23353890, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:27808481, ECO:0000269|PubMed:32409562, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:33650289, ECO:0000269|PubMed:35114100}.
Q9H7P6 MVB12B S309 ochoa|psp Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
Q9HAH7 FBRS S448 ochoa Probable fibrosin-1 None
Q9HCH3 CPNE5 T583 ochoa Copine-5 (Copine V) Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99829, ECO:0000269|PubMed:23999003}.
Q9HCM7 FBRSL1 S1034 ochoa Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) None
Q9NNX1 TUFT1 S378 ochoa Tuftelin Involved in the structural organization of the epidermis (PubMed:36689522). Involved in the mineralization and structural organization of enamel. {ECO:0000250|UniProtKB:P27628, ECO:0000269|PubMed:36689522}.
Q9NXX6 NSMCE4A T375 ochoa Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269|PubMed:18086888}.
Q9NYV6 RRN3 S640 ochoa RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}.
Q9P2N7 KLHL13 S645 ochoa Kelch-like protein 13 (BTB and kelch domain-containing protein 2) Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:19995937}.
Q9UKI8 TLK1 S755 ochoa Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}.
Q9UKK3 PARP4 S1713 ochoa Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}.
Q9ULK4 MED23 S1357 ochoa Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:10353252, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:16595664}.
Q9UPN7 PPP6R1 S870 ochoa Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}.
Q9UQ35 SRRM2 S2740 ochoa Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
Q9UQ49 NEU3 S417 ochoa Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidasedis) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3) Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:10405317, PubMed:10861246, PubMed:11298736, PubMed:12011038, PubMed:15847605, PubMed:20511247, PubMed:28646141). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452). {ECO:0000269|PubMed:10405317, ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:11298736, ECO:0000269|PubMed:12011038, ECO:0000269|PubMed:15847605, ECO:0000269|PubMed:17334392, ECO:0000269|PubMed:20511247, ECO:0000269|PubMed:25922362, ECO:0000269|PubMed:26251452, ECO:0000269|PubMed:28646141}.
Q9UQR1 ZNF148 S784 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9Y2G9 SBNO2 S1356 ochoa Protein strawberry notch homolog 2 Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the pro-inflammatory cascade (PubMed:18025162). {ECO:0000250|UniProtKB:Q7TNB8, ECO:0000269|PubMed:18025162}.
Q9Y3A2 UTP11 S241 ochoa Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein) Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000269|PubMed:34516797}.
Q9Y3X0 CCDC9 S521 ochoa Coiled-coil domain-containing protein 9 Probable component of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. {ECO:0000305|PubMed:33973408}.
Q9Y4D2 DAGLA S1030 ochoa Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}.
Q9Y4U1 MMACHC S271 ochoa Cyanocobalamin reductase / alkylcobalamin dealkylase (Alkylcobalamin:glutathione S-alkyltransferase) (EC 2.5.1.151) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) (EC 1.16.1.6) (Methylmalonic aciduria and homocystinuria type C protein) (MMACHC) Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485). Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555). Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510). Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485). The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555). Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555). {ECO:0000269|PubMed:18779575, ECO:0000269|PubMed:19700356, ECO:0000269|PubMed:19801555, ECO:0000269|PubMed:21071249, ECO:0000269|PubMed:21697092, ECO:0000269|PubMed:22642810, ECO:0000269|PubMed:25809485, ECO:0000269|PubMed:27771510, ECO:0000303|PubMed:19801555, ECO:0000303|PubMed:25535791}.
Q9Y5X2 SNX8 S456 ochoa Sorting nexin-8 May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. {ECO:0000269|PubMed:19782049}.
Q9Y606 PUS1 S415 ochoa Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs (PubMed:15772074, PubMed:24722331). Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA (PubMed:24722331). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:31477916, PubMed:35051350). Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA (PubMed:24722331). {ECO:0000269|PubMed:15772074, ECO:0000269|PubMed:24722331, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:35051350}.
Q9Y6G9 DYNC1LI1 T513 ochoa Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}.
Q9Y6R1 SLC4A4 S1069 ochoa Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:10069984, ECO:0000269|PubMed:11744745, ECO:0000269|PubMed:12411514, ECO:0000269|PubMed:12730338, ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:14567693, ECO:0000269|PubMed:15218065, ECO:0000269|PubMed:15713912, ECO:0000269|PubMed:15817634, ECO:0000269|PubMed:15930088, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:17661077, ECO:0000269|PubMed:23324180, ECO:0000269|PubMed:23636456, ECO:0000269|PubMed:29500354, ECO:0000269|PubMed:9235899, ECO:0000269|PubMed:9651366}.
Q9H3K6 BOLA2 T76 Sugiyama BolA-like protein 2 Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415). {ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}.
Q9UKN8 GTF3C4 S812 Sugiyama General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin (PubMed:10523658). Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3 (PubMed:10523658). May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F (PubMed:10523658). May be localized close to the A box (PubMed:10523658). {ECO:0000269|PubMed:10523658}.
Q9UKS6 PACSIN3 Y414 Sugiyama Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}.
P28324 ELK4 T420 GPS6 ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1) Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}.
Q01814 ATP2B2 S1231 Sugiyama Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). {ECO:0000250|UniProtKB:Q9R0K7, ECO:0000269|PubMed:15829536, ECO:0000269|PubMed:17234811, ECO:0000269|PubMed:25690014}.
Q15569 TESK1 T616 Sugiyama Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898, ECO:0000269|PubMed:25849865}.
A8MVS5 HIDE1 S217 ochoa Protein HIDE1 None
O00204 SULT2B1 S352 ochoa Sulfotransferase 2B1 (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (Sulfotransferase family 2B member 1) (Sulfotransferase family cytosolic 2B member 1) (ST2B1) Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol (PubMed:12145317, PubMed:19589875). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:12145317, PubMed:16855051, PubMed:21855633, PubMed:9799594). Preferentially sulfonates cholesterol, while it also has significant activity with pregnenolone and DHEA (PubMed:12145317, PubMed:21855633). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). {ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:16855051, ECO:0000269|PubMed:19589875, ECO:0000269|PubMed:21855633, ECO:0000269|PubMed:28575648, ECO:0000269|PubMed:9799594}.; FUNCTION: [Isoform 2]: Sulfonates pregnenolone but not cholesterol. {ECO:0000269|PubMed:12145317}.
O75947 ATP5PD Y150 ochoa ATP synthase peripheral stalk subunit d, mitochondrial (ATPase subunit d) (ATP synthase peripheral stalk subunit d) Subunit d, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity). {ECO:0000250|UniProtKB:P13620, ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}.
O95081 AGFG2 S468 ochoa Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev-binding protein-like protein) (Rev/Rex activation domain-binding protein related) (RAB-R) None
O95373 IPO7 S1026 ochoa Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. Promotes odontoblast differentiation via promoting nuclear translocation of DLX3, KLF4, SMAD2, thereby facilitating the transcription of target genes that play a role in odontoblast differentiation (By similarity). Facilitates BMP4-induced translocation of SMAD1 to the nucleus and recruitment to the MSX1 gene promoter, thereby promotes the expression of the odontogenic regulator MSX1 in dental mesenchymal cells (By similarity). Also promotes odontoblast differentiation by facilitating the nuclear translocation of HDAC6 and subsequent repression of RUNX2 expression (By similarity). Inhibits osteoblast differentiation by inhibiting nuclear translocation of RUNX2 and therefore inhibition of RUNX2 target gene transcription (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. {ECO:0000250|UniProtKB:Q9EPL8, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) Mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. Binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:12853482, ECO:0000269|PubMed:16704975}.
P10276 RARA S449 ochoa Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:21152046, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}.
P25686 DNAJB2 S311 ochoa DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:22219199, PubMed:7957263). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). {ECO:0000269|PubMed:12754272, ECO:0000269|PubMed:15936278, ECO:0000269|PubMed:20889486, ECO:0000269|PubMed:21625540, ECO:0000269|PubMed:21719532, ECO:0000269|PubMed:22219199, ECO:0000269|PubMed:22396390, ECO:0000269|PubMed:24023695, ECO:0000269|PubMed:7957263}.
P30048 PRDX3 S243 ochoa Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3) Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMed:29438714, PubMed:33889951, PubMed:7733872). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity). {ECO:0000250|UniProtKB:P20108, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:17707404, ECO:0000269|PubMed:29438714, ECO:0000269|PubMed:33889951, ECO:0000269|PubMed:7733872}.
P34932 HSPA4 S828 ochoa Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) None
P49639 HOXA1 S322 ochoa Homeobox protein Hox-A1 (Homeobox protein Hox-1F) Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). {ECO:0000250|UniProtKB:P09022, ECO:0000250|UniProtKB:Q90423, ECO:0000269|PubMed:16155570}.
P49716 CEBPD S256 ochoa CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta) Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16397300, PubMed:1741402). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). {ECO:0000269|PubMed:1741402}.
P52746 ZNF142 S1674 ochoa Zinc finger protein 142 May be involved in transcriptional regulation. {ECO:0000305}.
Q01130 SRSF2 S208 ochoa Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}.
Q05193 DNM1 S851 psp Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I) Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209, PubMed:20428113, PubMed:29668686, PubMed:8101525, PubMed:8910402, PubMed:9362482). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:30069048, PubMed:7877694, PubMed:9922133). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). {ECO:0000250|UniProtKB:P39053, ECO:0000250|UniProtKB:Q08DF4, ECO:0000269|PubMed:12791276, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:19084269, ECO:0000269|PubMed:20428113, ECO:0000269|PubMed:29668686, ECO:0000269|PubMed:30069048, ECO:0000269|PubMed:7877694, ECO:0000269|PubMed:8101525, ECO:0000269|PubMed:8910402, ECO:0000269|PubMed:9362482, ECO:0000269|PubMed:9922133}.
Q13164 MAPK7 S803 psp Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
Q16581 C3AR1 S470 ochoa|psp C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Q5TZA2 CROCC S2005 ochoa Rootletin (Ciliary rootlet coiled-coil protein) Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.
Q86UR5 RIMS1 S1680 ochoa Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99NE5, ECO:0000269|PubMed:23999003}.
Q8TEM1 NUP210 S1874 ochoa Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. {ECO:0000269|PubMed:14517331}.
Q92928 RAB1C S190 ochoa Putative Ras-related protein Rab-1C (hRab1c) (EC 3.6.5.2) Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250|UniProtKB:P62820}.
Q9H0U4 RAB1B S190 ochoa Ras-related protein Rab-1B (EC 3.6.5.2) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:26209634, ECO:0000269|PubMed:9437002}.
Q9H426 RIMS4 S257 ochoa Regulating synaptic membrane exocytosis protein 4 (RIM4 gamma) (Rab3-interacting molecule 4) (RIM 4) Regulates synaptic membrane exocytosis. {ECO:0000250}.
Q9HCD6 TANC2 S1977 ochoa Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2) Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. {ECO:0000269|PubMed:30021165}.
Q9NVM1 EVA1B S152 ochoa Protein eva-1 homolog B (Protein FAM176B) None
Q9P203 BTBD7 S1119 ochoa BTB/POZ domain-containing protein 7 Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity). {ECO:0000250}.
Q9P2J3 KLHL9 S605 ochoa Kelch-like protein 9 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:17543862, ECO:0000269|PubMed:19995937}.
Q9ULV8 CBLC S461 ochoa E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C) Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269|PubMed:10362357, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:18753381, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:23145173}.
Q9UQ26 RIMS2 S1399 ochoa Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3) Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:23999003}.
Q9Y3F4 STRAP S338 ochoa Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}.
Q9Y6G9 DYNC1LI1 S510 ochoa Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). {ECO:0000269|PubMed:19229290, ECO:0000269|PubMed:20026645}.
P61158 ACTR3 S406 Sugiyama Actin-related protein 3 (Actin-like protein 3) ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}.
O14965 AURKA S391 GPS6|ELM|EPSD|PSP Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A) Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:14523000, PubMed:26246606). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:11551964, PubMed:14702041, PubMed:15128871, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18056443, PubMed:18615013). Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (PubMed:27192185). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27192185, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.
Q86X55 CARM1 S595 SIGNOR Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:12237300, PubMed:16497732, PubMed:19405910). Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activation of transcription via chromatin remodeling (PubMed:12237300, PubMed:16497732, PubMed:19405910). During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (By similarity). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (By similarity). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (By similarity). Acts as a coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (By similarity). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (By similarity). Also seems to be involved in p53/TP53 transcriptional activation (By similarity). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation (PubMed:15731352). Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs (By similarity). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (By similarity). Independently of its methyltransferase activity, involved in replication fork progression: promotes PARP1 recruitment to replication forks, leading to poly-ADP-ribosylation of chromatin at replication forks and reduced fork speed (PubMed:33412112). {ECO:0000250|UniProtKB:Q9WVG6, ECO:0000269|PubMed:12237300, ECO:0000269|PubMed:15731352, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:33412112}.
Q00526 CDK3 S292 Sugiyama Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. {ECO:0000269|PubMed:15084261, ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:8846921}.
Download
reactome_id name p -log10_p
R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 0.000019 4.727
R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.000023 4.646
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.000018 4.734
R-HSA-383280 Nuclear Receptor transcription pathway 0.000342 3.465
R-HSA-9909396 Circadian clock 0.000197 3.705
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.000339 3.470
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.000568 3.246
R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... 0.000843 3.074
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer 0.001651 2.782
R-HSA-3304347 Loss of Function of SMAD4 in Cancer 0.001651 2.782
R-HSA-3311021 SMAD4 MH2 Domain Mutants in Cancer 0.001651 2.782
R-HSA-196025 Formation of annular gap junctions 0.001403 2.853
R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 0.001403 2.853
R-HSA-352238 Breakdown of the nuclear lamina 0.001651 2.782
R-HSA-190873 Gap junction degradation 0.001795 2.746
R-HSA-1640170 Cell Cycle 0.002626 2.581
R-HSA-9006936 Signaling by TGFB family members 0.003007 2.522
R-HSA-69278 Cell Cycle, Mitotic 0.003095 2.509
R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... 0.003847 2.415
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.004751 2.323
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.004751 2.323
R-HSA-3656532 TGFBR1 KD Mutants in Cancer 0.006355 2.197
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.006355 2.197
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.005855 2.232
R-HSA-446353 Cell-extracellular matrix interactions 0.006447 2.191
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.007413 2.130
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 0.008539 2.069
R-HSA-5619507 Activation of HOX genes during differentiation 0.008479 2.072
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.008479 2.072
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 0.008539 2.069
R-HSA-8849470 PTK6 Regulates Cell Cycle 0.011011 1.958
R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 0.011011 1.958
R-HSA-6802957 Oncogenic MAPK signaling 0.010640 1.973
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.010802 1.966
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to cla... 0.009589 2.018
R-HSA-69205 G1/S-Specific Transcription 0.010625 1.974
R-HSA-69615 G1/S DNA Damage Checkpoints 0.013596 1.867
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 0.013759 1.861
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.016512 1.782
R-HSA-2682334 EPH-Ephrin signaling 0.016053 1.794
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.016512 1.782
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 0.016771 1.775
R-HSA-9660537 Signaling by MRAS-complex mutants 0.020036 1.698
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 0.020036 1.698
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.019858 1.702
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.018157 1.741
R-HSA-3928662 EPHB-mediated forward signaling 0.019858 1.702
R-HSA-9012546 Interleukin-18 signaling 0.020036 1.698
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.019889 1.701
R-HSA-69206 G1/S Transition 0.021462 1.668
R-HSA-428543 Inactivation of CDC42 and RAC1 0.023544 1.628
R-HSA-9839394 TGFBR3 expression 0.023618 1.627
R-HSA-9614085 FOXO-mediated transcription 0.022250 1.653
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.023765 1.624
R-HSA-162906 HIV Infection 0.025120 1.600
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.026611 1.575
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.026611 1.575
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 0.027282 1.564
R-HSA-9828806 Maturation of hRSV A proteins 0.027700 1.558
R-HSA-5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) 0.038370 1.416
R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 0.057001 1.244
R-HSA-5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalit... 0.057001 1.244
R-HSA-3359473 Defective MMADHC causes MMAHCD 0.057001 1.244
R-HSA-8854521 Interaction between PHLDA1 and AURKA 0.075272 1.123
R-HSA-198765 Signalling to ERK5 0.075272 1.123
R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) 0.075272 1.123
R-HSA-5684045 Defective ABCD1 causes ALD 0.075272 1.123
R-HSA-5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 0.075272 1.123
R-HSA-3814836 Glycogen storage disease type XV (GYG1) 0.075272 1.123
R-HSA-5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 0.075272 1.123
R-HSA-3359474 Defective MMACHC causes MAHCC 0.093191 1.031
R-HSA-8952158 RUNX3 regulates BCL2L11 (BIM) transcription 0.110763 0.956
R-HSA-187706 Signalling to p38 via RIT and RIN 0.144895 0.839
R-HSA-9652817 Signaling by MAPK mutants 0.144895 0.839
R-HSA-8932506 DAG1 core M1 glycosylations 0.177722 0.750
R-HSA-8932504 DAG1 core M2 glycosylations 0.193661 0.713
R-HSA-3785653 Myoclonic epilepsy of Lafora 0.193661 0.713
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.032132 1.493
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.086779 1.062
R-HSA-390450 Folding of actin by CCT/TriC 0.224621 0.649
R-HSA-8932505 DAG1 core M3 glycosylations 0.239654 0.620
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.053284 1.273
R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.254396 0.594
R-HSA-202670 ERKs are inactivated 0.254396 0.594
R-HSA-9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 0.254396 0.594
R-HSA-9861559 PDH complex synthesizes acetyl-CoA from PYR 0.283031 0.548
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.150370 0.823
R-HSA-72165 mRNA Splicing - Minor Pathway 0.090640 1.043
R-HSA-8854518 AURKA Activation by TPX2 0.058808 1.231
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.040286 1.395
R-HSA-73780 RNA Polymerase III Chain Elongation 0.310569 0.508
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.065976 1.181
R-HSA-72187 mRNA 3'-end processing 0.114530 0.941
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.076204 1.118
R-HSA-9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 0.337054 0.472
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.101909 0.992
R-HSA-3928664 Ephrin signaling 0.362523 0.441
R-HSA-73980 RNA Polymerase III Transcription Termination 0.362523 0.441
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.234578 0.630
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.163494 0.786
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.163494 0.786
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.374890 0.426
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.374890 0.426
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.172989 0.762
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.248961 0.604
R-HSA-167161 HIV Transcription Initiation 0.248961 0.604
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.248961 0.604
R-HSA-163210 Formation of ATP by chemiosmotic coupling 0.387018 0.412
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.387018 0.412
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.387018 0.412
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.387018 0.412
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.387018 0.412
R-HSA-73776 RNA Polymerase II Promoter Escape 0.263371 0.579
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.277785 0.556
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.212370 0.673
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.284986 0.545
R-HSA-380287 Centrosome maturation 0.222507 0.653
R-HSA-6803529 FGFR2 alternative splicing 0.422011 0.375
R-HSA-73772 RNA Polymerase I Promoter Escape 0.327962 0.484
R-HSA-72163 mRNA Splicing - Major Pathway 0.127368 0.895
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.335066 0.475
R-HSA-72172 mRNA Splicing 0.152711 0.816
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.295513 0.529
R-HSA-1989781 PPARA activates gene expression 0.252258 0.598
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.234038 0.631
R-HSA-9823730 Formation of definitive endoderm 0.086779 1.062
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.259561 0.586
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.306114 0.514
R-HSA-74158 RNA Polymerase III Transcription 0.053284 1.273
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.056300 1.249
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.283031 0.548
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.348585 0.458
R-HSA-204005 COPII-mediated vesicle transport 0.197365 0.705
R-HSA-69202 Cyclin E associated events during G1/S transition 0.068461 1.165
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.131632 0.881
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.034479 1.462
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.170894 0.767
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.159481 0.797
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 0.036912 1.433
R-HSA-9939291 Matriglycan biosynthesis on DAG1 0.398911 0.399
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 0.086779 1.062
R-HSA-198753 ERK/MAPK targets 0.092702 1.033
R-HSA-2025928 Calcineurin activates NFAT 0.209292 0.679
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.177836 0.750
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.198903 0.701
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.213107 0.671
R-HSA-5674135 MAP2K and MAPK activation 0.248961 0.604
R-HSA-162599 Late Phase of HIV Life Cycle 0.096548 1.015
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.335066 0.475
R-HSA-9664417 Leishmania phagocytosis 0.368785 0.433
R-HSA-9664407 Parasite infection 0.368785 0.433
R-HSA-9664422 FCGR3A-mediated phagocytosis 0.368785 0.433
R-HSA-432720 Lysosome Vesicle Biogenesis 0.053284 1.273
R-HSA-199977 ER to Golgi Anterograde Transport 0.403891 0.394
R-HSA-8856688 Golgi-to-ER retrograde transport 0.329173 0.483
R-HSA-1483248 Synthesis of PIPs at the ER membrane 0.239654 0.620
R-HSA-9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 0.170894 0.767
R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.118723 0.925
R-HSA-9656223 Signaling by RAF1 mutants 0.248961 0.604
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.284986 0.545
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.284986 0.545
R-HSA-9649948 Signaling downstream of RAS mutants 0.284986 0.545
R-HSA-68877 Mitotic Prometaphase 0.237336 0.625
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.191845 0.717
R-HSA-9932298 Degradation of CRY and PER proteins 0.248961 0.604
R-HSA-9754189 Germ layer formation at gastrulation 0.080977 1.092
R-HSA-201451 Signaling by BMP 0.136987 0.863
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.073576 1.133
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells 0.031242 1.505
R-HSA-5624138 Trafficking of myristoylated proteins to the cilium 0.127996 0.893
R-HSA-8941855 RUNX3 regulates CDKN1A transcription 0.144895 0.839
R-HSA-174490 Membrane binding and targetting of GAG proteins 0.044353 1.353
R-HSA-9796292 Formation of axial mesoderm 0.044353 1.353
R-HSA-162588 Budding and maturation of HIV virion 0.036912 1.433
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.044722 1.349
R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.123891 0.907
R-HSA-8982491 Glycogen metabolism 0.065822 1.182
R-HSA-445095 Interaction between L1 and Ankyrins 0.136987 0.863
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.283031 0.548
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.283031 0.548
R-HSA-9603798 Class I peroxisomal membrane protein import 0.323941 0.490
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.191845 0.717
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.122972 0.910
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.362523 0.441
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.374890 0.426
R-HSA-73762 RNA Polymerase I Transcription Initiation 0.256164 0.591
R-HSA-3322077 Glycogen synthesis 0.387018 0.412
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.422011 0.375
R-HSA-191859 snRNP Assembly 0.377165 0.423
R-HSA-194441 Metabolism of non-coding RNA 0.377165 0.423
R-HSA-168325 Viral Messenger RNA Synthesis 0.390960 0.408
R-HSA-5696398 Nucleotide Excision Repair 0.401242 0.397
R-HSA-9843745 Adipogenesis 0.163446 0.787
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.404617 0.393
R-HSA-199992 trans-Golgi Network Vesicle Budding 0.207340 0.683
R-HSA-69236 G1 Phase 0.083195 1.080
R-HSA-69231 Cyclin D associated events in G1 0.083195 1.080
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.123891 0.907
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.373184 0.428
R-HSA-6802949 Signaling by RAS mutants 0.284986 0.545
R-HSA-162587 HIV Life Cycle 0.131311 0.882
R-HSA-1181150 Signaling by NODAL 0.086779 1.062
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 0.111125 0.954
R-HSA-210745 Regulation of gene expression in beta cells 0.150370 0.823
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.035927 1.445
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.049102 1.309
R-HSA-1502540 Signaling by Activin 0.054026 1.267
R-HSA-3229121 Glycogen storage diseases 0.349913 0.456
R-HSA-9020265 Biosynthesis of aspirin-triggered D-series resolvins 0.349913 0.456
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.220245 0.657
R-HSA-8873719 RAB geranylgeranylation 0.149562 0.825
R-HSA-8856828 Clathrin-mediated endocytosis 0.040781 1.390
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.422011 0.375
R-HSA-2980766 Nuclear Envelope Breakdown 0.039969 1.398
R-HSA-68886 M Phase 0.029088 1.536
R-HSA-9018676 Biosynthesis of D-series resolvins 0.422011 0.375
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.380287 0.420
R-HSA-5578775 Ion homeostasis 0.131632 0.881
R-HSA-68882 Mitotic Anaphase 0.182799 0.738
R-HSA-8981607 Intracellular oxygen transport 0.093191 1.031
R-HSA-77108 Utilization of Ketone Bodies 0.031242 1.505
R-HSA-9026403 Biosynthesis of DPAn-3-derived 13-series resolvins 0.127996 0.893
R-HSA-418359 Reduction of cytosolic Ca++ levels 0.035414 1.451
R-HSA-9615710 Late endosomal microautophagy 0.032132 1.493
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.034479 1.462
R-HSA-426048 Arachidonate production from DAG 0.224621 0.649
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 0.224621 0.649
R-HSA-9706019 RHOBTB3 ATPase cycle 0.239654 0.620
R-HSA-9026286 Biosynthesis of DPAn-3-derived protectins and resolvins 0.268853 0.570
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.296935 0.527
R-HSA-177504 Retrograde neurotrophin signalling 0.296935 0.527
R-HSA-1221632 Meiotic synapsis 0.118723 0.925
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.095886 1.018
R-HSA-2142700 Biosynthesis of Lipoxins (LX) 0.362523 0.441
R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 0.362523 0.441
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.398911 0.399
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... 0.398911 0.399
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.222507 0.653
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.185412 0.732
R-HSA-199991 Membrane Trafficking 0.041578 1.381
R-HSA-9609646 HCMV Infection 0.279107 0.554
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.044240 1.354
R-HSA-9610379 HCMV Late Events 0.259561 0.586
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.150370 0.823
R-HSA-186712 Regulation of beta-cell development 0.377165 0.423
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.062570 1.204
R-HSA-9932444 ATP-dependent chromatin remodelers 0.123891 0.907
R-HSA-9932451 SWI/SNF chromatin remodelers 0.123891 0.907
R-HSA-69052 Switching of origins to a post-replicative state 0.212370 0.673
R-HSA-68875 Mitotic Prophase 0.124773 0.904
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 0.054026 1.267
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.069762 1.156
R-HSA-1679131 Trafficking and processing of endosomal TLR 0.268853 0.570
R-HSA-9023661 Biosynthesis of E-series 18(R)-resolvins 0.296935 0.527
R-HSA-437239 Recycling pathway of L1 0.094463 1.025
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.063538 1.197
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.198903 0.701
R-HSA-5653656 Vesicle-mediated transport 0.138345 0.859
R-HSA-8953854 Metabolism of RNA 0.410708 0.386
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.064364 1.191
R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.049938 1.302
R-HSA-390466 Chaperonin-mediated protein folding 0.120978 0.917
R-HSA-69242 S Phase 0.408259 0.389
R-HSA-201688 WNT mediated activation of DVL 0.209292 0.679
R-HSA-425381 Bicarbonate transporters 0.239654 0.620
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.254396 0.594
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.038125 1.419
R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 0.323941 0.490
R-HSA-432047 Passive transport by Aquaporins 0.337054 0.472
R-HSA-9764561 Regulation of CDH1 Function 0.136041 0.866
R-HSA-73856 RNA Polymerase II Transcription Termination 0.154163 0.812
R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids 0.374890 0.426
R-HSA-3238698 WNT ligand biogenesis and trafficking 0.422011 0.375
R-HSA-9659379 Sensory processing of sound 0.092940 1.032
R-HSA-2132295 MHC class II antigen presentation 0.054350 1.265
R-HSA-69275 G2/M Transition 0.215455 0.667
R-HSA-1483255 PI Metabolism 0.182157 0.740
R-HSA-6787450 tRNA modification in the mitochondrion 0.064364 1.191
R-HSA-9733709 Cardiogenesis 0.177836 0.750
R-HSA-9018896 Biosynthesis of E-series 18(S)-resolvins 0.398911 0.399
R-HSA-453274 Mitotic G2-G2/M phases 0.221635 0.654
R-HSA-6809371 Formation of the cornified envelope 0.285510 0.544
R-HSA-450294 MAP kinase activation 0.154163 0.812
R-HSA-9762293 Regulation of CDH11 gene transcription 0.209292 0.679
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.104881 0.979
R-HSA-983189 Kinesins 0.384079 0.416
R-HSA-5576891 Cardiac conduction 0.324781 0.488
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... 0.144895 0.839
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.054026 1.267
R-HSA-9675126 Diseases of mitotic cell cycle 0.039430 1.404
R-HSA-9026290 Biosynthesis of DPAn-3-derived maresins 0.239654 0.620
R-HSA-190828 Gap junction trafficking 0.083195 1.080
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.296935 0.527
R-HSA-419408 Lysosphingolipid and LPA receptors 0.310569 0.508
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.184821 0.733
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.323941 0.490
R-HSA-9733458 Induction of Cell-Cell Fusion 0.323941 0.490
R-HSA-448424 Interleukin-17 signaling 0.197365 0.705
R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.410574 0.387
R-HSA-156584 Cytosolic sulfonation of small molecules 0.320838 0.494
R-HSA-8943724 Regulation of PTEN gene transcription 0.384079 0.416
R-HSA-9018519 Estrogen-dependent gene expression 0.032437 1.489
R-HSA-422475 Axon guidance 0.317334 0.498
R-HSA-9675108 Nervous system development 0.294670 0.531
R-HSA-69620 Cell Cycle Checkpoints 0.098623 1.006
R-HSA-5362517 Signaling by Retinoic Acid 0.384079 0.416
R-HSA-74160 Gene expression (Transcription) 0.054015 1.267
R-HSA-162909 Host Interactions of HIV factors 0.136182 0.866
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.277785 0.556
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.277785 0.556
R-HSA-391251 Protein folding 0.141450 0.849
R-HSA-936837 Ion transport by P-type ATPases 0.168222 0.774
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.283031 0.548
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.049938 1.302
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.296935 0.527
R-HSA-5578768 Physiological factors 0.296935 0.527
R-HSA-157858 Gap junction trafficking and regulation 0.102305 0.990
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 0.323941 0.490
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.191845 0.717
R-HSA-8939211 ESR-mediated signaling 0.068307 1.166
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.040286 1.395
R-HSA-73857 RNA Polymerase II Transcription 0.104321 0.982
R-HSA-1538133 G0 and Early G1 0.170894 0.767
R-HSA-9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 0.184821 0.733
R-HSA-9675135 Diseases of DNA repair 0.284986 0.545
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.209292 0.679
R-HSA-5689896 Ovarian tumor domain proteases 0.213107 0.671
R-HSA-6787639 GDP-fucose biosynthesis 0.349913 0.456
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.387018 0.412
R-HSA-193648 NRAGE signals death through JNK 0.356238 0.448
R-HSA-9824594 Regulation of MITF-M-dependent genes involved in apoptosis 0.092702 1.033
R-HSA-6783783 Interleukin-10 signaling 0.090038 1.046
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.416829 0.380
R-HSA-9839373 Signaling by TGFBR3 0.090640 1.043
R-HSA-187037 Signaling by NTRK1 (TRKA) 0.307260 0.512
R-HSA-175474 Assembly Of The HIV Virion 0.098738 1.006
R-HSA-418360 Platelet calcium homeostasis 0.150370 0.823
R-HSA-1500620 Meiosis 0.274391 0.562
R-HSA-9006931 Signaling by Nuclear Receptors 0.134490 0.871
R-HSA-9824446 Viral Infection Pathways 0.318354 0.497
R-HSA-2559583 Cellular Senescence 0.098508 1.007
R-HSA-9707616 Heme signaling 0.158807 0.799
R-HSA-983712 Ion channel transport 0.384688 0.415
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.207340 0.683
R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.359179 0.445
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.359179 0.445
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.359179 0.445
R-HSA-209543 p75NTR recruits signalling complexes 0.268853 0.570
R-HSA-198323 AKT phosphorylates targets in the cytosol 0.268853 0.570
R-HSA-9683610 Maturation of nucleoprotein 0.283031 0.548
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.296935 0.527
R-HSA-416700 Other semaphorin interactions 0.310569 0.508
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.374890 0.426
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 0.398911 0.399
R-HSA-446728 Cell junction organization 0.231409 0.636
R-HSA-69239 Synthesis of DNA 0.411647 0.385
R-HSA-421270 Cell-cell junction organization 0.282129 0.550
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.176873 0.752
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.176873 0.752
R-HSA-9764560 Regulation of CDH1 Gene Transcription 0.197365 0.705
R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.421996 0.375
R-HSA-418990 Adherens junctions interactions 0.323415 0.490
R-HSA-9827857 Specification of primordial germ cells 0.069762 1.156
R-HSA-212436 Generic Transcription Pathway 0.183231 0.737
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.246916 0.607
R-HSA-5688426 Deubiquitination 0.174208 0.759
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.401242 0.397
R-HSA-1500931 Cell-Cell communication 0.337228 0.472
R-HSA-74182 Ketone body metabolism 0.111125 0.954
R-HSA-8863678 Neurodegenerative Diseases 0.117464 0.930
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 0.117464 0.930
R-HSA-1474165 Reproduction 0.160314 0.795
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.057855 1.238
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 0.136987 0.863
R-HSA-5673000 RAF activation 0.191845 0.717
R-HSA-727802 Transport of nucleotide sugars 0.374890 0.426
R-HSA-112409 RAF-independent MAPK1/3 activation 0.422011 0.375
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.408259 0.389
R-HSA-166520 Signaling by NTRKs 0.408259 0.389
R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases 0.268853 0.570
R-HSA-193639 p75NTR signals via NF-kB 0.310569 0.508
R-HSA-446652 Interleukin-1 family signaling 0.241404 0.617
R-HSA-5689880 Ub-specific processing proteases 0.323294 0.490
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.253818 0.595
R-HSA-9694631 Maturation of nucleoprotein 0.374890 0.426
R-HSA-73942 DNA Damage Reversal 0.310569 0.508
R-HSA-8953750 Transcriptional Regulation by E2F6 0.227404 0.643
R-HSA-163560 Triglyceride catabolism 0.053284 1.273
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 0.248961 0.604
R-HSA-3700989 Transcriptional Regulation by TP53 0.246281 0.609
R-HSA-352230 Amino acid transport across the plasma membrane 0.377165 0.423
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.056517 1.248
R-HSA-111465 Apoptotic cleavage of cellular proteins 0.170894 0.767
R-HSA-168898 Toll-like Receptor Cascades 0.392375 0.406
R-HSA-373755 Semaphorin interactions 0.404617 0.393
R-HSA-9607240 FLT3 Signaling 0.241765 0.617
R-HSA-381038 XBP1(S) activates chaperone genes 0.117699 0.929
R-HSA-1280215 Cytokine Signaling in Immune system 0.239954 0.620
R-HSA-8979227 Triglyceride metabolism 0.145008 0.839
R-HSA-449147 Signaling by Interleukins 0.052680 1.278
R-HSA-5633007 Regulation of TP53 Activity 0.270607 0.568
R-HSA-193704 p75 NTR receptor-mediated signalling 0.364467 0.438
R-HSA-381070 IRE1alpha activates chaperones 0.137946 0.860
R-HSA-8848021 Signaling by PTK6 0.404617 0.393
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 0.404617 0.393
R-HSA-9020591 Interleukin-12 signaling 0.084367 1.074
R-HSA-75153 Apoptotic execution phase 0.284986 0.545
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 0.362523 0.441
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 0.062570 1.204
R-HSA-381119 Unfolded Protein Response (UPR) 0.192689 0.715
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.355576 0.449
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex 0.422011 0.375
R-HSA-447115 Interleukin-12 family signaling 0.120978 0.917
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.424822 0.372
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.425661 0.371
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 0.427148 0.369
R-HSA-166166 MyD88-independent TLR4 cascade 0.427148 0.369
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.431478 0.365
R-HSA-9958863 SLC-mediated transport of amino acids 0.431478 0.365
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.433227 0.363
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.433227 0.363
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.433227 0.363
R-HSA-1369062 ABC transporters in lipid homeostasis 0.433227 0.363
R-HSA-9018682 Biosynthesis of maresins 0.433227 0.363
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.433227 0.363
R-HSA-167172 Transcription of the HIV genome 0.438093 0.358
R-HSA-376176 Signaling by ROBO receptors 0.438253 0.358
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.442503 0.354
R-HSA-9612973 Autophagy 0.442933 0.354
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.444227 0.352
R-HSA-429947 Deadenylation of mRNA 0.444227 0.352
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.451197 0.346
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.455013 0.342
R-HSA-420029 Tight junction interactions 0.455013 0.342
R-HSA-3296469 Defects in cobalamin (B12) metabolism 0.455013 0.342
R-HSA-9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 0.455013 0.342
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.455013 0.342
R-HSA-3214842 HDMs demethylate histones 0.455013 0.342
R-HSA-400685 Sema4D in semaphorin signaling 0.455013 0.342
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.455013 0.342
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.457683 0.339
R-HSA-453276 Regulation of mitotic cell cycle 0.457683 0.339
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.457683 0.339
R-HSA-5632684 Hedgehog 'on' state 0.457683 0.339
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.457697 0.339
R-HSA-909733 Interferon alpha/beta signaling 0.462723 0.335
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.462723 0.335
R-HSA-5578749 Transcriptional regulation by small RNAs 0.464125 0.333
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.464125 0.333
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.465591 0.332
R-HSA-2046105 Linoleic acid (LA) metabolism 0.465591 0.332
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.465591 0.332
R-HSA-373760 L1CAM interactions 0.467729 0.330
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.470522 0.327
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.470522 0.327
R-HSA-2262752 Cellular responses to stress 0.470650 0.327
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.475964 0.322
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.475964 0.322
R-HSA-73863 RNA Polymerase I Transcription Termination 0.475964 0.322
R-HSA-9759218 Cobalamin (Cbl) metabolism 0.475964 0.322
R-HSA-8949613 Cristae formation 0.475964 0.322
R-HSA-9025094 Biosynthesis of DPAn-3 SPMs 0.475964 0.322
R-HSA-3928663 EPHA-mediated growth cone collapse 0.475964 0.322
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.476873 0.322
R-HSA-9013694 Signaling by NOTCH4 0.476873 0.322
R-HSA-69473 G2/M DNA damage checkpoint 0.476873 0.322
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.482620 0.316
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.482620 0.316
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.483178 0.316
R-HSA-1169408 ISG15 antiviral mechanism 0.483178 0.316
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.486136 0.313
R-HSA-113418 Formation of the Early Elongation Complex 0.486136 0.313
R-HSA-167287 HIV elongation arrest and recovery 0.486136 0.313
R-HSA-167290 Pausing and recovery of HIV elongation 0.486136 0.313
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 0.486136 0.313
R-HSA-5620971 Pyroptosis 0.486136 0.313
R-HSA-73854 RNA Polymerase I Promoter Clearance 0.489436 0.310
R-HSA-5689603 UCH proteinases 0.489436 0.310
R-HSA-3371556 Cellular response to heat stress 0.492438 0.308
R-HSA-72086 mRNA Capping 0.496111 0.304
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 0.496111 0.304
R-HSA-9018679 Biosynthesis of EPA-derived SPMs 0.496111 0.304
R-HSA-9759475 Regulation of CDH11 Expression and Function 0.496111 0.304
R-HSA-180024 DARPP-32 events 0.496111 0.304
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.497312 0.303
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.497312 0.303
R-HSA-73864 RNA Polymerase I Transcription 0.501808 0.299
R-HSA-5619084 ABC transporter disorders 0.501808 0.299
R-HSA-416482 G alpha (12/13) signalling events 0.501808 0.299
R-HSA-162582 Signal Transduction 0.502261 0.299
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.505894 0.296
R-HSA-9008059 Interleukin-37 signaling 0.505894 0.296
R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.505894 0.296
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.505894 0.296
R-HSA-72306 tRNA processing 0.506109 0.296
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 0.507921 0.294
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.507921 0.294
R-HSA-8951664 Neddylation 0.509034 0.293
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.515487 0.288
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.515487 0.288
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.515487 0.288
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.515487 0.288
R-HSA-399719 Trafficking of AMPA receptors 0.515487 0.288
R-HSA-9018683 Biosynthesis of DPA-derived SPMs 0.515487 0.288
R-HSA-5694530 Cargo concentration in the ER 0.515487 0.288
R-HSA-194138 Signaling by VEGF 0.516570 0.287
R-HSA-5693607 Processing of DNA double-strand break ends 0.520000 0.284
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.522427 0.282
R-HSA-8931838 DAG1 glycosylations 0.524894 0.280
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.524894 0.280
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.525965 0.279
R-HSA-69481 G2/M Checkpoints 0.526050 0.279
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.526467 0.279
R-HSA-9678108 SARS-CoV-1 Infection 0.526467 0.279
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 0.534120 0.272
R-HSA-1855170 IPs transport between nucleus and cytosol 0.534120 0.272
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.534120 0.272
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.534120 0.272
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.534120 0.272
R-HSA-176187 Activation of ATR in response to replication stress 0.534120 0.272
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 0.534120 0.272
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 0.534120 0.272
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.534120 0.272
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.537745 0.269
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.537745 0.269
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.543167 0.265
R-HSA-5693537 Resolution of D-Loop Structures 0.543167 0.265
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.543167 0.265
R-HSA-180534 Vpu mediated degradation of CD4 0.543167 0.265
R-HSA-114508 Effects of PIP2 hydrolysis 0.543167 0.265
R-HSA-6794362 Protein-protein interactions at synapses 0.543559 0.265
R-HSA-141424 Amplification of signal from the kinetochores 0.549322 0.260
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.549322 0.260
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.549322 0.260
R-HSA-168638 NOD1/2 Signaling Pathway 0.552038 0.258
R-HSA-180746 Nuclear import of Rev protein 0.552038 0.258
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.552038 0.258
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.552038 0.258
R-HSA-203615 eNOS activation 0.552038 0.258
R-HSA-1266738 Developmental Biology 0.559743 0.252
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.560738 0.251
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.560738 0.251
R-HSA-169911 Regulation of Apoptosis 0.560738 0.251
R-HSA-3296482 Defects in vitamin and cofactor metabolism 0.560738 0.251
R-HSA-2559585 Oncogene Induced Senescence 0.560738 0.251
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.560738 0.251
R-HSA-187687 Signalling to ERKs 0.560738 0.251
R-HSA-381042 PERK regulates gene expression 0.560738 0.251
R-HSA-5673001 RAF/MAP kinase cascade 0.563060 0.249
R-HSA-9645723 Diseases of programmed cell death 0.566304 0.247
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.569270 0.245
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.569270 0.245
R-HSA-114604 GPVI-mediated activation cascade 0.569270 0.245
R-HSA-8941326 RUNX2 regulates bone development 0.569270 0.245
R-HSA-1839126 FGFR2 mutant receptor activation 0.569270 0.245
R-HSA-8853659 RET signaling 0.569270 0.245
R-HSA-202424 Downstream TCR signaling 0.577367 0.239
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.577636 0.238
R-HSA-4641258 Degradation of DVL 0.577636 0.238
R-HSA-4641257 Degradation of AXIN 0.577636 0.238
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.577636 0.238
R-HSA-390247 Beta-oxidation of very long chain fatty acids 0.577636 0.238
R-HSA-5684996 MAPK1/MAPK3 signaling 0.584832 0.233
R-HSA-5617833 Cilium Assembly 0.584959 0.233
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.585840 0.232
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.585840 0.232
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism 0.585840 0.232
R-HSA-9958790 SLC-mediated transport of inorganic anions 0.585840 0.232
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 0.585840 0.232
R-HSA-6807070 PTEN Regulation 0.589399 0.230
R-HSA-9772573 Late SARS-CoV-2 Infection Events 0.593573 0.227
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.593885 0.226
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.593885 0.226
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 0.593885 0.226
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.593885 0.226
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.593885 0.226
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.593885 0.226
R-HSA-69541 Stabilization of p53 0.593885 0.226
R-HSA-5619115 Disorders of transmembrane transporters 0.599428 0.222
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.601775 0.221
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.601775 0.221
R-HSA-167169 HIV Transcription Elongation 0.601775 0.221
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.601775 0.221
R-HSA-9646399 Aggrephagy 0.601775 0.221
R-HSA-177243 Interactions of Rev with host cellular proteins 0.601775 0.221
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.601775 0.221
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.601775 0.221
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.601775 0.221
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 0.601775 0.221
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 0.601775 0.221
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.601775 0.221
R-HSA-9837999 Mitochondrial protein degradation 0.604118 0.219
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... 0.609512 0.215
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.609512 0.215
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.609512 0.215
R-HSA-5362768 Hh mutants are degraded by ERAD 0.609512 0.215
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.609512 0.215
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.617099 0.210
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.617099 0.210
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.617099 0.210
R-HSA-5675221 Negative regulation of MAPK pathway 0.617099 0.210
R-HSA-9683701 Translation of Structural Proteins 0.617099 0.210
R-HSA-6807878 COPI-mediated anterograde transport 0.619545 0.208
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.619545 0.208
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.621549 0.207
R-HSA-8878159 Transcriptional regulation by RUNX3 0.624584 0.204
R-HSA-948021 Transport to the Golgi and subsequent modification 0.628619 0.202
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.631835 0.199
R-HSA-8854214 TBC/RABGAPs 0.631835 0.199
R-HSA-9758941 Gastrulation 0.635203 0.197
R-HSA-9907900 Proteasome assembly 0.638989 0.195
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 0.638989 0.195
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 0.638989 0.195
R-HSA-3214858 RMTs methylate histone arginines 0.638989 0.195
R-HSA-9679191 Potential therapeutics for SARS 0.639186 0.194
R-HSA-9856651 MITF-M-dependent gene expression 0.639186 0.194
R-HSA-69618 Mitotic Spindle Checkpoint 0.639390 0.194
R-HSA-5610787 Hedgehog 'off' state 0.639390 0.194
R-HSA-70171 Glycolysis 0.639390 0.194
R-HSA-382556 ABC-family proteins mediated transport 0.639390 0.194
R-HSA-5357801 Programmed Cell Death 0.642507 0.192
R-HSA-9009391 Extra-nuclear estrogen signaling 0.644223 0.191
R-HSA-9020702 Interleukin-1 signaling 0.644223 0.191
R-HSA-6805567 Keratinization 0.645925 0.190
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.646005 0.190
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.646005 0.190
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.646005 0.190
R-HSA-4608870 Asymmetric localization of PCP proteins 0.646005 0.190
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.646005 0.190
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.646005 0.190
R-HSA-9824272 Somitogenesis 0.646005 0.190
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.647061 0.189
R-HSA-9734767 Developmental Cell Lineages 0.650155 0.187
R-HSA-9609507 Protein localization 0.650953 0.186
R-HSA-69306 DNA Replication 0.650953 0.186
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.652885 0.185
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.652885 0.185
R-HSA-9861718 Regulation of pyruvate metabolism 0.652885 0.185
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 0.652885 0.185
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 0.652885 0.185
R-HSA-73887 Death Receptor Signaling 0.654814 0.184
R-HSA-1852241 Organelle biogenesis and maintenance 0.654986 0.184
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.659632 0.181
R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.659632 0.181
R-HSA-445989 TAK1-dependent IKK and NF-kappa-B activation 0.659632 0.181
R-HSA-397014 Muscle contraction 0.665982 0.177
R-HSA-9031628 NGF-stimulated transcription 0.666248 0.176
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.669953 0.174
R-HSA-9692914 SARS-CoV-1-host interactions 0.672151 0.173
R-HSA-418346 Platelet homeostasis 0.672151 0.173
R-HSA-9766229 Degradation of CDH1 0.672736 0.172
R-HSA-380108 Chemokine receptors bind chemokines 0.672736 0.172
R-HSA-211000 Gene Silencing by RNA 0.676630 0.170
R-HSA-5658442 Regulation of RAS by GAPs 0.679098 0.168
R-HSA-5655253 Signaling by FGFR2 in disease 0.679098 0.168
R-HSA-2672351 Stimuli-sensing channels 0.681058 0.167
R-HSA-8953897 Cellular responses to stimuli 0.683776 0.165
R-HSA-1474244 Extracellular matrix organization 0.684594 0.165
R-HSA-109581 Apoptosis 0.684601 0.165
R-HSA-1169091 Activation of NF-kappaB in B cells 0.685337 0.164
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.685337 0.164
R-HSA-5358346 Hedgehog ligand biogenesis 0.685337 0.164
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.685437 0.164
R-HSA-202403 TCR signaling 0.689767 0.161
R-HSA-112382 Formation of RNA Pol II elongation complex 0.691455 0.160
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.691455 0.160
R-HSA-68949 Orc1 removal from chromatin 0.691455 0.160
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.691455 0.160
R-HSA-6794361 Neurexins and neuroligins 0.691455 0.160
R-HSA-2467813 Separation of Sister Chromatids 0.691742 0.160
R-HSA-9679506 SARS-CoV Infections 0.692064 0.160
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.697454 0.156
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.697454 0.156
R-HSA-8948751 Regulation of PTEN stability and activity 0.697454 0.156
R-HSA-1483249 Inositol phosphate metabolism 0.698280 0.156
R-HSA-9824443 Parasitic Infection Pathways 0.702151 0.154
R-HSA-9658195 Leishmania infection 0.702151 0.154
R-HSA-5619102 SLC transporter disorders 0.702226 0.154
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.706599 0.151
R-HSA-3214815 HDACs deacetylate histones 0.709106 0.149
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.709106 0.149
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.709106 0.149
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.714763 0.146
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.714763 0.146
R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.714763 0.146
R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.718718 0.143
R-HSA-5683057 MAPK family signaling cascades 0.724622 0.140
R-HSA-6782135 Dual incision in TC-NER 0.725750 0.139
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.725750 0.139
R-HSA-9772572 Early SARS-CoV-2 Infection Events 0.725750 0.139
R-HSA-9007101 Rab regulation of trafficking 0.726563 0.139
R-HSA-70326 Glucose metabolism 0.726563 0.139
R-HSA-1592230 Mitochondrial biogenesis 0.726563 0.139
R-HSA-5693538 Homology Directed Repair 0.730415 0.136
R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.730415 0.136
R-HSA-429914 Deadenylation-dependent mRNA decay 0.731085 0.136
R-HSA-4085001 Sialic acid metabolism 0.731085 0.136
R-HSA-8878166 Transcriptional regulation by RUNX2 0.734221 0.134
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.736316 0.133
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 0.736316 0.133
R-HSA-351202 Metabolism of polyamines 0.736316 0.133
R-HSA-1257604 PIP3 activates AKT signaling 0.738733 0.132
R-HSA-445717 Aquaporin-mediated transport 0.741445 0.130
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.741445 0.130
R-HSA-9793380 Formation of paraxial mesoderm 0.741445 0.130
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.741697 0.130
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.741697 0.130
R-HSA-6784531 tRNA processing in the nucleus 0.746476 0.127
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.746476 0.127
R-HSA-9616222 Transcriptional regulation of granulopoiesis 0.746476 0.127
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.746476 0.127
R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.751408 0.124
R-HSA-73894 DNA Repair 0.754445 0.122
R-HSA-977606 Regulation of Complement cascade 0.756112 0.121
R-HSA-5690714 CD22 mediated BCR regulation 0.756245 0.121
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.756245 0.121
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.759605 0.119
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.759605 0.119
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.759605 0.119
R-HSA-1234174 Cellular response to hypoxia 0.760988 0.119
R-HSA-375276 Peptide ligand-binding receptors 0.765251 0.116
R-HSA-196807 Nicotinate metabolism 0.770200 0.113
R-HSA-4839726 Chromatin organization 0.772249 0.112
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.774672 0.111
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 0.774672 0.111
R-HSA-5218859 Regulated Necrosis 0.774672 0.111
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.782869 0.106
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.783358 0.106
R-HSA-9840310 Glycosphingolipid catabolism 0.783358 0.106
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.783358 0.106
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.787575 0.104
R-HSA-427413 NoRC negatively regulates rRNA expression 0.787575 0.104
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.787575 0.104
R-HSA-3000178 ECM proteoglycans 0.787575 0.104
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 0.787575 0.104
R-HSA-499943 Interconversion of nucleotide di- and triphosphates 0.791710 0.101
R-HSA-9609690 HCMV Early Events 0.792471 0.101
R-HSA-5663084 Diseases of carbohydrate metabolism 0.795765 0.099
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 0.799742 0.097
R-HSA-1226099 Signaling by FGFR in disease 0.799742 0.097
R-HSA-913531 Interferon Signaling 0.803199 0.095
R-HSA-5358351 Signaling by Hedgehog 0.807021 0.093
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.809927 0.092
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.811213 0.091
R-HSA-9694635 Translation of Structural Proteins 0.811213 0.091
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.814890 0.089
R-HSA-4086400 PCP/CE pathway 0.814890 0.089
R-HSA-216083 Integrin cell surface interactions 0.814890 0.089
R-HSA-1632852 Macroautophagy 0.815445 0.089
R-HSA-9711123 Cellular response to chemical stress 0.815526 0.089
R-HSA-5663205 Infectious disease 0.818182 0.087
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.820878 0.086
R-HSA-5654738 Signaling by FGFR2 0.822030 0.085
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.822030 0.085
R-HSA-9018677 Biosynthesis of DHA-derived SPMs 0.825496 0.083
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.825496 0.083
R-HSA-2871837 FCERI mediated NF-kB activation 0.826167 0.083
R-HSA-166658 Complement cascade 0.828758 0.082
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.832228 0.080
R-HSA-9707564 Cytoprotection by HMOX1 0.832228 0.080
R-HSA-9730414 MITF-M-regulated melanocyte development 0.834849 0.078
R-HSA-390918 Peroxisomal lipid metabolism 0.835497 0.078
R-HSA-9006925 Intracellular signaling by second messengers 0.837370 0.077
R-HSA-597592 Post-translational protein modification 0.838632 0.076
R-HSA-5687128 MAPK6/MAPK4 signaling 0.838702 0.076
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.841844 0.075
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.842920 0.074
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.843591 0.074
R-HSA-70268 Pyruvate metabolism 0.847948 0.072
R-HSA-5693532 DNA Double-Strand Break Repair 0.848270 0.071
R-HSA-9694516 SARS-CoV-2 Infection 0.849082 0.071
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.850562 0.070
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.850562 0.070
R-HSA-173623 Classical antibody-mediated complement activation 0.850911 0.070
R-HSA-9663891 Selective autophagy 0.850911 0.070
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.852823 0.069
R-HSA-1236974 ER-Phagosome pathway 0.853816 0.069
R-HSA-112310 Neurotransmitter release cycle 0.856665 0.067
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, L... 0.857251 0.067
R-HSA-8878171 Transcriptional regulation by RUNX1 0.860639 0.065
R-HSA-877300 Interferon gamma signaling 0.861557 0.065
R-HSA-1483257 Phospholipid metabolism 0.865225 0.063
R-HSA-446203 Asparagine N-linked glycosylation 0.866024 0.062
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.866065 0.062
R-HSA-2029481 FCGR activation 0.867519 0.062
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 0.867519 0.062
R-HSA-68867 Assembly of the pre-replicative complex 0.867519 0.062
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.870101 0.060
R-HSA-1474290 Collagen formation 0.870101 0.060
R-HSA-3247509 Chromatin modifying enzymes 0.874698 0.058
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.875117 0.058
R-HSA-2168880 Scavenging of heme from plasma 0.875117 0.058
R-HSA-5389840 Mitochondrial translation elongation 0.877553 0.057
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.877553 0.057
R-HSA-157579 Telomere Maintenance 0.879940 0.056
R-HSA-5368286 Mitochondrial translation initiation 0.882282 0.054
R-HSA-190236 Signaling by FGFR 0.882282 0.054
R-HSA-3214847 HATs acetylate histones 0.884578 0.053
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.884991 0.053
R-HSA-5621481 C-type lectin receptors (CLRs) 0.886769 0.052
R-HSA-9842860 Regulation of endogenous retroelements 0.891201 0.050
R-HSA-2559580 Oxidative Stress Induced Senescence 0.891201 0.050
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.893323 0.049
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.895404 0.048
R-HSA-111885 Opioid Signalling 0.895404 0.048
R-HSA-9833110 RSV-host interactions 0.897445 0.047
R-HSA-168255 Influenza Infection 0.900102 0.046
R-HSA-166786 Creation of C4 and C2 activators 0.901408 0.045
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.903332 0.044
R-HSA-9700206 Signaling by ALK in cancer 0.903332 0.044
R-HSA-212165 Epigenetic regulation of gene expression 0.904218 0.044
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.905218 0.043
R-HSA-1236975 Antigen processing-Cross presentation 0.905218 0.043
R-HSA-201681 TCF dependent signaling in response to WNT 0.906207 0.043
R-HSA-5419276 Mitochondrial translation termination 0.907068 0.042
R-HSA-69002 DNA Replication Pre-Initiation 0.907068 0.042
R-HSA-6798695 Neutrophil degranulation 0.907354 0.042
R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.909805 0.041
R-HSA-2871796 FCERI mediated MAPK activation 0.912404 0.040
R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.913349 0.039
R-HSA-416476 G alpha (q) signalling events 0.916868 0.038
R-HSA-166663 Initial triggering of complement 0.917435 0.037
R-HSA-1643685 Disease 0.918098 0.037
R-HSA-2029485 Role of phospholipids in phagocytosis 0.920628 0.036
R-HSA-418594 G alpha (i) signalling events 0.922551 0.035
R-HSA-76002 Platelet activation, signaling and aggregation 0.927761 0.033
R-HSA-73886 Chromosome Maintenance 0.929486 0.032
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.930575 0.031
R-HSA-1280218 Adaptive Immune System 0.931504 0.031
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.932214 0.030
R-HSA-1660662 Glycosphingolipid metabolism 0.932214 0.030
R-HSA-168256 Immune System 0.937177 0.028
R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.937359 0.028
R-HSA-114608 Platelet degranulation 0.938583 0.028
R-HSA-199418 Negative regulation of the PI3K/AKT network 0.942114 0.026
R-HSA-1474228 Degradation of the extracellular matrix 0.945442 0.024
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.946509 0.024
R-HSA-195721 Signaling by WNT 0.948781 0.023
R-HSA-388396 GPCR downstream signalling 0.950332 0.022
R-HSA-3858494 Beta-catenin independent WNT signaling 0.950572 0.022
R-HSA-5173105 O-linked glycosylation 0.951538 0.022
R-HSA-5368287 Mitochondrial translation 0.952486 0.021
R-HSA-9948299 Ribosome-associated quality control 0.952486 0.021
R-HSA-109582 Hemostasis 0.955008 0.020
R-HSA-9705683 SARS-CoV-2-host interactions 0.955375 0.020
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.956620 0.019
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.956822 0.019
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.956891 0.019
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs) 0.957797 0.019
R-HSA-72312 rRNA processing 0.958224 0.019
R-HSA-382551 Transport of small molecules 0.958227 0.019
R-HSA-156580 Phase II - Conjugation of compounds 0.962795 0.016
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.963250 0.016
R-HSA-157118 Signaling by NOTCH 0.963407 0.016
R-HSA-425407 SLC-mediated transmembrane transport 0.964123 0.016
R-HSA-2142753 Arachidonate metabolism 0.964674 0.016
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.976684 0.010
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.977141 0.010
R-HSA-9664433 Leishmania parasite growth and survival 0.977141 0.010
R-HSA-372790 Signaling by GPCR 0.978880 0.009
R-HSA-3781865 Diseases of glycosylation 0.981615 0.008
R-HSA-168249 Innate Immune System 0.983050 0.007
R-HSA-389948 Co-inhibition by PD-1 0.986612 0.006
R-HSA-428157 Sphingolipid metabolism 0.986875 0.006
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.989655 0.005
R-HSA-112315 Transmission across Chemical Synapses 0.991093 0.004
R-HSA-8957322 Metabolism of steroids 0.991246 0.004
R-HSA-500792 GPCR ligand binding 0.992847 0.003
R-HSA-5668914 Diseases of metabolism 0.993026 0.003
R-HSA-392499 Metabolism of proteins 0.993185 0.003
R-HSA-1428517 Aerobic respiration and respiratory electron transport 0.993494 0.003
R-HSA-15869 Metabolism of nucleotides 0.993578 0.003
R-HSA-202733 Cell surface interactions at the vascular wall 0.993704 0.003
R-HSA-196854 Metabolism of vitamins and cofactors 0.995660 0.002
R-HSA-388841 Regulation of T cell activation by CD28 family 0.995686 0.002
R-HSA-112316 Neuronal System 0.996412 0.002
R-HSA-556833 Metabolism of lipids 0.996490 0.002
R-HSA-8978868 Fatty acid metabolism 0.998018 0.001
R-HSA-72766 Translation 0.998666 0.001
R-HSA-211859 Biological oxidations 0.999761 0.000
R-HSA-71291 Metabolism of amino acids and derivatives 0.999997 0.000
R-HSA-9709957 Sensory Perception 1.000000 0.000
R-HSA-9752946 Expression and translocation of olfactory receptors 1.000000 0.000
R-HSA-381753 Olfactory Signaling Pathway 1.000000 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
HIPK2HIPK2 0.894 0.796 1 0.923
CDK1CDK1 0.894 0.836 1 0.905
P38GP38G 0.894 0.860 1 0.931
JNK2JNK2 0.893 0.866 1 0.908
CDK3CDK3 0.892 0.770 1 0.930
CDK18CDK18 0.890 0.832 1 0.920
P38BP38B 0.889 0.845 1 0.893
P38DP38D 0.889 0.846 1 0.940
CDK17CDK17 0.887 0.836 1 0.929
ERK1ERK1 0.885 0.827 1 0.904
DYRK2DYRK2 0.884 0.774 1 0.867
CDK5CDK5 0.883 0.797 1 0.875
JNK3JNK3 0.883 0.847 1 0.894
CDK19CDK19 0.881 0.813 1 0.901
CLK3CLK3 0.880 0.584 1 0.648
CDK16CDK16 0.880 0.800 1 0.924
DYRK4DYRK4 0.880 0.781 1 0.925
P38AP38A 0.880 0.815 1 0.853
CDK7CDK7 0.880 0.807 1 0.890
HIPK1HIPK1 0.879 0.722 1 0.852
CDK13CDK13 0.879 0.809 1 0.903
CDK12CDK12 0.878 0.812 1 0.912
CDK8CDK8 0.878 0.808 1 0.878
CDK10CDK10 0.876 0.768 1 0.908
CDK14CDK14 0.876 0.798 1 0.895
DYRK1BDYRK1B 0.873 0.737 1 0.896
KISKIS 0.872 0.740 1 0.868
HIPK4HIPK4 0.871 0.562 1 0.698
ERK2ERK2 0.869 0.797 1 0.870
CDK9CDK9 0.867 0.780 1 0.896
MAKMAK 0.867 0.600 -2 0.854
DYRK1ADYRK1A 0.866 0.652 1 0.817
NLKNLK 0.866 0.722 1 0.682
JNK1JNK1 0.865 0.761 1 0.907
CDK6CDK6 0.864 0.769 1 0.903
SRPK1SRPK1 0.864 0.417 -3 0.818
HIPK3HIPK3 0.864 0.689 1 0.814
CDK4CDK4 0.864 0.787 1 0.920
CLK2CLK2 0.859 0.482 -3 0.811
DYRK3DYRK3 0.858 0.576 1 0.823
CDK2CDK2 0.857 0.627 1 0.810
ICKICK 0.857 0.455 -3 0.879
ERK5ERK5 0.856 0.423 1 0.615
MOKMOK 0.852 0.539 1 0.774
CLK1CLK1 0.850 0.450 -3 0.792
CDKL5CDKL5 0.850 0.265 -3 0.846
CLK4CLK4 0.850 0.416 -3 0.812
CDKL1CDKL1 0.850 0.240 -3 0.854
SRPK2SRPK2 0.844 0.334 -3 0.744
PRP4PRP4 0.843 0.482 -3 0.806
MTORMTOR 0.843 0.259 1 0.472
SRPK3SRPK3 0.842 0.303 -3 0.792
COTCOT 0.841 -0.001 2 0.851
MOSMOS 0.839 0.046 1 0.390
PIM3PIM3 0.835 0.059 -3 0.888
ATRATR 0.833 -0.008 1 0.377
PRPKPRPK 0.832 -0.072 -1 0.812
CAMK1BCAMK1B 0.831 0.019 -3 0.885
SKMLCKSKMLCK 0.830 0.020 -2 0.854
CHAK2CHAK2 0.829 0.016 -1 0.811
NIKNIK 0.829 -0.015 -3 0.893
CDC7CDC7 0.829 -0.055 1 0.331
PIM1PIM1 0.829 0.090 -3 0.837
NUAK2NUAK2 0.829 0.064 -3 0.879
ERK7ERK7 0.828 0.273 2 0.547
PKN3PKN3 0.827 0.006 -3 0.870
CAMLCKCAMLCK 0.827 0.014 -2 0.837
MPSK1MPSK1 0.826 0.139 1 0.426
BMPR2BMPR2 0.826 -0.170 -2 0.866
LATS1LATS1 0.824 0.080 -3 0.889
DAPK2DAPK2 0.824 -0.007 -3 0.889
WNK1WNK1 0.824 -0.048 -2 0.876
NDR2NDR2 0.824 0.056 -3 0.890
PRKD1PRKD1 0.823 0.069 -3 0.865
RSK2RSK2 0.823 0.061 -3 0.828
RAF1RAF1 0.823 -0.170 1 0.321
PKCDPKCD 0.822 0.015 2 0.758
TBK1TBK1 0.821 -0.134 1 0.270
P90RSKP90RSK 0.821 0.061 -3 0.827
MST4MST4 0.821 -0.024 2 0.839
AMPKA1AMPKA1 0.821 -0.012 -3 0.885
PKN2PKN2 0.820 -0.021 -3 0.870
GRK7GRK7 0.820 0.053 1 0.327
GSK3AGSK3A 0.820 0.247 4 0.508
PRKD2PRKD2 0.820 0.070 -3 0.825
PDHK4PDHK4 0.819 -0.182 1 0.384
NDR1NDR1 0.819 -0.006 -3 0.873
TSSK1TSSK1 0.818 0.009 -3 0.905
TSSK2TSSK2 0.817 -0.031 -5 0.872
BMPR1BBMPR1B 0.817 -0.016 1 0.297
VRK2VRK2 0.817 0.042 1 0.432
MLK3MLK3 0.817 -0.014 2 0.725
MLK1MLK1 0.817 -0.127 2 0.791
PKRPKR 0.817 -0.078 1 0.368
AMPKA2AMPKA2 0.816 0.010 -3 0.862
DSTYKDSTYK 0.816 -0.146 2 0.871
MLK2MLK2 0.816 -0.092 2 0.801
IKKEIKKE 0.815 -0.152 1 0.267
NEK6NEK6 0.815 -0.077 -2 0.840
MARK4MARK4 0.815 -0.044 4 0.865
CAMK2GCAMK2G 0.815 -0.112 2 0.776
RIPK3RIPK3 0.814 -0.136 3 0.748
IRE1IRE1 0.814 -0.068 1 0.349
GRK1GRK1 0.814 0.005 -2 0.773
GRK5GRK5 0.814 -0.136 -3 0.862
DLKDLK 0.813 -0.170 1 0.320
P70S6KBP70S6KB 0.813 0.011 -3 0.837
TGFBR2TGFBR2 0.813 -0.086 -2 0.784
AURCAURC 0.813 0.039 -2 0.659
PINK1PINK1 0.813 0.156 1 0.554
IKKBIKKB 0.813 -0.143 -2 0.707
PKCBPKCB 0.813 0.007 2 0.717
PASKPASK 0.812 0.061 -3 0.905
PKCAPKCA 0.812 0.014 2 0.709
MAPKAPK3MAPKAPK3 0.812 -0.010 -3 0.816
ALK4ALK4 0.812 -0.061 -2 0.811
RSK3RSK3 0.812 0.021 -3 0.821
AKT2AKT2 0.812 0.074 -3 0.753
DNAPKDNAPK 0.812 -0.024 1 0.328
PDHK1PDHK1 0.812 -0.218 1 0.358
PKCZPKCZ 0.811 -0.012 2 0.763
MASTLMASTL 0.811 -0.165 -2 0.799
PKACGPKACG 0.811 -0.002 -2 0.738
PRKD3PRKD3 0.811 0.040 -3 0.794
RSK4RSK4 0.811 0.063 -3 0.813
IRE2IRE2 0.810 -0.050 2 0.709
MAPKAPK2MAPKAPK2 0.810 0.033 -3 0.786
PIM2PIM2 0.810 0.063 -3 0.797
LATS2LATS2 0.810 -0.005 -5 0.765
HUNKHUNK 0.810 -0.163 2 0.794
CAMK2DCAMK2D 0.809 -0.067 -3 0.864
PKCGPKCG 0.809 -0.006 2 0.722
MST3MST3 0.809 -0.025 2 0.836
ULK2ULK2 0.809 -0.234 2 0.754
ANKRD3ANKRD3 0.808 -0.213 1 0.346
RIPK1RIPK1 0.808 -0.191 1 0.325
NEK7NEK7 0.808 -0.205 -3 0.823
GAKGAK 0.807 0.008 1 0.406
CHAK1CHAK1 0.807 -0.100 2 0.787
TGFBR1TGFBR1 0.807 -0.057 -2 0.785
CAMK2ACAMK2A 0.807 0.022 2 0.773
GRK6GRK6 0.807 -0.128 1 0.312
BUB1BUB1 0.807 0.097 -5 0.833
YSK4YSK4 0.806 -0.155 1 0.287
PKACBPKACB 0.806 0.052 -2 0.669
ATMATM 0.806 -0.078 1 0.329
NEK9NEK9 0.806 -0.214 2 0.809
PAK1PAK1 0.806 -0.036 -2 0.777
QSKQSK 0.806 -0.002 4 0.847
SGK3SGK3 0.806 0.015 -3 0.817
DCAMKL1DCAMKL1 0.805 -0.008 -3 0.831
MNK1MNK1 0.805 0.009 -2 0.787
GCN2GCN2 0.805 -0.239 2 0.771
SMG1SMG1 0.805 -0.063 1 0.359
MEK1MEK1 0.805 -0.176 2 0.822
MNK2MNK2 0.805 -0.020 -2 0.780
TAO3TAO3 0.805 -0.026 1 0.336
NUAK1NUAK1 0.804 -0.007 -3 0.827
MELKMELK 0.804 -0.056 -3 0.840
WNK3WNK3 0.803 -0.236 1 0.324
IKKAIKKA 0.803 -0.082 -2 0.703
PKG2PKG2 0.803 0.015 -2 0.678
PKCHPKCH 0.803 -0.040 2 0.698
PHKG1PHKG1 0.803 -0.042 -3 0.860
MEK5MEK5 0.803 -0.163 2 0.803
GCKGCK 0.803 -0.023 1 0.330
AURBAURB 0.802 -0.007 -2 0.650
CAMK2BCAMK2B 0.802 -0.029 2 0.752
MYLK4MYLK4 0.802 -0.017 -2 0.752
MEKK2MEKK2 0.802 -0.127 2 0.775
MLK4MLK4 0.802 -0.098 2 0.697
ALK2ALK2 0.802 -0.081 -2 0.794
PAK3PAK3 0.801 -0.073 -2 0.767
NEK5NEK5 0.801 -0.146 1 0.336
NIM1NIM1 0.801 -0.101 3 0.783
CAMK4CAMK4 0.801 -0.102 -3 0.847
ACVR2AACVR2A 0.801 -0.094 -2 0.769
ACVR2BACVR2B 0.801 -0.090 -2 0.778
MSK1MSK1 0.800 0.015 -3 0.802
CAMK1GCAMK1G 0.800 -0.015 -3 0.805
QIKQIK 0.800 -0.093 -3 0.855
LKB1LKB1 0.800 -0.029 -3 0.834
GSK3BGSK3B 0.800 0.083 4 0.502
SMMLCKSMMLCK 0.800 -0.020 -3 0.855
PRKXPRKX 0.799 0.077 -3 0.752
WNK4WNK4 0.799 -0.117 -2 0.872
NEK2NEK2 0.799 -0.165 2 0.798
IRAK4IRAK4 0.799 -0.119 1 0.321
MSK2MSK2 0.799 -0.013 -3 0.798
TLK2TLK2 0.799 -0.135 1 0.324
CHK1CHK1 0.799 -0.042 -3 0.847
MEKK1MEKK1 0.799 -0.174 1 0.324
PDK1PDK1 0.799 -0.052 1 0.346
PLK1PLK1 0.799 -0.161 -2 0.779
TNIKTNIK 0.798 -0.017 3 0.902
MEKK3MEKK3 0.798 -0.172 1 0.317
DRAK1DRAK1 0.798 -0.119 1 0.274
MARK3MARK3 0.798 -0.024 4 0.808
AKT1AKT1 0.797 0.035 -3 0.770
PAK2PAK2 0.797 -0.078 -2 0.757
LRRK2LRRK2 0.797 -0.009 2 0.827
TTBK2TTBK2 0.797 -0.202 2 0.687
SIKSIK 0.796 -0.019 -3 0.801
KHS1KHS1 0.796 -0.008 1 0.320
KHS2KHS2 0.796 0.017 1 0.334
BCKDKBCKDK 0.796 -0.191 -1 0.730
DCAMKL2DCAMKL2 0.796 -0.038 -3 0.839
PKCEPKCE 0.796 0.029 2 0.710
TAO2TAO2 0.796 -0.068 2 0.822
ZAKZAK 0.796 -0.179 1 0.285
NEK11NEK11 0.795 -0.140 1 0.327
BMPR1ABMPR1A 0.795 -0.055 1 0.275
HPK1HPK1 0.795 -0.047 1 0.325
SSTKSSTK 0.795 -0.032 4 0.839
MAP3K15MAP3K15 0.795 -0.083 1 0.296
ULK1ULK1 0.795 -0.229 -3 0.781
HGKHGK 0.795 -0.058 3 0.905
EEF2KEEF2K 0.794 -0.039 3 0.888
PBKPBK 0.794 -0.007 1 0.381
PAK6PAK6 0.794 -0.009 -2 0.687
GRK2GRK2 0.794 -0.090 -2 0.686
HASPINHASPIN 0.794 0.047 -1 0.691
PERKPERK 0.793 -0.190 -2 0.820
HRIHRI 0.793 -0.194 -2 0.829
MINKMINK 0.793 -0.103 1 0.305
GRK4GRK4 0.793 -0.181 -2 0.801
PKCTPKCT 0.793 -0.041 2 0.703
BRSK1BRSK1 0.793 -0.038 -3 0.834
PKCIPKCI 0.793 -0.023 2 0.729
BRAFBRAF 0.793 -0.188 -4 0.826
BRSK2BRSK2 0.792 -0.067 -3 0.840
DAPK3DAPK3 0.792 -0.018 -3 0.845
NEK8NEK8 0.792 -0.166 2 0.795
MARK2MARK2 0.792 -0.055 4 0.767
FAM20CFAM20C 0.792 -0.017 2 0.602
MEKK6MEKK6 0.791 -0.117 1 0.321
AURAAURA 0.791 -0.025 -2 0.617
SBKSBK 0.791 0.152 -3 0.641
DMPK1DMPK1 0.791 0.059 -3 0.811
ROCK2ROCK2 0.790 0.013 -3 0.832
SGK1SGK1 0.790 0.069 -3 0.683
PKACAPKACA 0.789 0.029 -2 0.624
PLK3PLK3 0.789 -0.144 2 0.751
PLK4PLK4 0.789 -0.150 2 0.603
TLK1TLK1 0.789 -0.170 -2 0.803
CAMK1DCAMK1D 0.788 -0.002 -3 0.736
NEK4NEK4 0.788 -0.175 1 0.312
LOKLOK 0.788 -0.075 -2 0.755
CAMKK2CAMKK2 0.788 -0.153 -2 0.743
NEK1NEK1 0.787 -0.152 1 0.310
MRCKBMRCKB 0.787 0.016 -3 0.789
MST2MST2 0.787 -0.150 1 0.311
AKT3AKT3 0.787 0.057 -3 0.701
MARK1MARK1 0.787 -0.082 4 0.826
CAMKK1CAMKK1 0.786 -0.212 -2 0.738
CHK2CHK2 0.786 0.022 -3 0.696
MRCKAMRCKA 0.786 0.005 -3 0.796
SLKSLK 0.785 -0.063 -2 0.700
CK1ECK1E 0.785 -0.019 -3 0.566
BIKEBIKE 0.785 -0.005 1 0.388
DAPK1DAPK1 0.785 -0.023 -3 0.834
CK1DCK1D 0.785 0.007 -3 0.515
VRK1VRK1 0.785 -0.170 2 0.809
MST1MST1 0.784 -0.138 1 0.301
AAK1AAK1 0.784 0.044 1 0.379
TAK1TAK1 0.784 -0.186 1 0.310
PKN1PKN1 0.784 -0.008 -3 0.770
P70S6KP70S6K 0.783 -0.018 -3 0.757
PHKG2PHKG2 0.782 -0.073 -3 0.831
MAPKAPK5MAPKAPK5 0.782 -0.077 -3 0.760
SNRKSNRK 0.781 -0.174 2 0.656
CAMK1ACAMK1A 0.781 0.015 -3 0.717
YSK1YSK1 0.780 -0.124 2 0.787
CRIKCRIK 0.780 0.045 -3 0.771
MYO3BMYO3B 0.777 -0.057 2 0.809
PAK5PAK5 0.777 -0.041 -2 0.629
CK1A2CK1A2 0.776 -0.026 -3 0.518
GRK3GRK3 0.775 -0.090 -2 0.641
TTKTTK 0.775 -0.086 -2 0.805
ROCK1ROCK1 0.775 -0.006 -3 0.797
OSR1OSR1 0.775 -0.087 2 0.783
CK2A2CK2A2 0.774 -0.053 1 0.269
STK33STK33 0.773 -0.133 2 0.610
PAK4PAK4 0.773 -0.027 -2 0.638
ASK1ASK1 0.771 -0.140 1 0.288
IRAK1IRAK1 0.771 -0.284 -1 0.691
MYO3AMYO3A 0.770 -0.091 1 0.334
TTBK1TTBK1 0.768 -0.198 2 0.608
TAO1TAO1 0.768 -0.094 1 0.288
MEK2MEK2 0.768 -0.263 2 0.785
PLK2PLK2 0.767 -0.090 -3 0.753
ALPHAK3ALPHAK3 0.766 -0.092 -1 0.716
CK2A1CK2A1 0.766 -0.056 1 0.254
NEK3NEK3 0.765 -0.182 1 0.307
CK1G1CK1G1 0.763 -0.073 -3 0.552
RIPK2RIPK2 0.762 -0.260 1 0.262
PKG1PKG1 0.757 -0.028 -2 0.598
PDHK3_TYRPDHK3_TYR 0.757 0.205 4 0.905
YANK3YANK3 0.756 -0.057 2 0.405
PDHK4_TYRPDHK4_TYR 0.750 0.127 2 0.866
LIMK2_TYRLIMK2_TYR 0.750 0.157 -3 0.895
TESK1_TYRTESK1_TYR 0.750 0.087 3 0.890
STLK3STLK3 0.749 -0.222 1 0.267
MAP2K4_TYRMAP2K4_TYR 0.746 0.056 -1 0.826
MAP2K6_TYRMAP2K6_TYR 0.745 0.069 -1 0.836
PKMYT1_TYRPKMYT1_TYR 0.745 0.110 3 0.851
MAP2K7_TYRMAP2K7_TYR 0.742 -0.048 2 0.837
BMPR2_TYRBMPR2_TYR 0.741 0.023 -1 0.817
PDHK1_TYRPDHK1_TYR 0.741 0.007 -1 0.844
PINK1_TYRPINK1_TYR 0.738 -0.106 1 0.378
LIMK1_TYRLIMK1_TYR 0.735 -0.015 2 0.825
RETRET 0.733 -0.125 1 0.331
CK1ACK1A 0.731 -0.044 -3 0.425
JAK2JAK2 0.728 -0.127 1 0.328
EPHA6EPHA6 0.728 -0.104 -1 0.788
CSF1RCSF1R 0.728 -0.090 3 0.802
MST1RMST1R 0.727 -0.126 3 0.813
TYK2TYK2 0.727 -0.204 1 0.319
ROS1ROS1 0.727 -0.125 3 0.795
TNNI3K_TYRTNNI3K_TYR 0.727 -0.028 1 0.355
TXKTXK 0.726 -0.057 1 0.293
FGRFGR 0.726 -0.118 1 0.329
NEK10_TYRNEK10_TYR 0.725 -0.094 1 0.282
YANK2YANK2 0.725 -0.083 2 0.416
EPHB4EPHB4 0.725 -0.125 -1 0.759
ABL2ABL2 0.724 -0.112 -1 0.739
YES1YES1 0.724 -0.094 -1 0.790
TYRO3TYRO3 0.724 -0.170 3 0.821
JAK3JAK3 0.724 -0.125 1 0.310
TNK1TNK1 0.723 -0.063 3 0.790
TNK2TNK2 0.723 -0.094 3 0.759
DDR1DDR1 0.722 -0.146 4 0.826
JAK1JAK1 0.722 -0.079 1 0.287
LCKLCK 0.722 -0.068 -1 0.771
BLKBLK 0.722 -0.054 -1 0.781
KDRKDR 0.719 -0.094 3 0.765
ABL1ABL1 0.719 -0.134 -1 0.725
INSRRINSRR 0.718 -0.145 3 0.762
FGFR2FGFR2 0.718 -0.083 3 0.795
HCKHCK 0.717 -0.143 -1 0.766
CK1G3CK1G3 0.717 -0.063 -3 0.383
TEKTEK 0.717 -0.048 3 0.757
KITKIT 0.716 -0.133 3 0.803
ITKITK 0.716 -0.131 -1 0.725
EPHA4EPHA4 0.716 -0.103 2 0.763
WEE1_TYRWEE1_TYR 0.716 -0.077 -1 0.680
DDR2DDR2 0.715 -0.022 3 0.751
FERFER 0.715 -0.211 1 0.324
FGFR1FGFR1 0.714 -0.087 3 0.771
FYNFYN 0.713 -0.065 -1 0.757
METMET 0.713 -0.118 3 0.788
FLT3FLT3 0.711 -0.198 3 0.820
PDGFRBPDGFRB 0.711 -0.231 3 0.820
EPHB1EPHB1 0.711 -0.184 1 0.288
BMXBMX 0.710 -0.112 -1 0.651
SRMSSRMS 0.710 -0.195 1 0.293
EPHB3EPHB3 0.709 -0.179 -1 0.740
FLT1FLT1 0.709 -0.127 -1 0.767
FGFR3FGFR3 0.708 -0.090 3 0.767
PDGFRAPDGFRA 0.708 -0.225 3 0.819
EPHB2EPHB2 0.707 -0.175 -1 0.731
AXLAXL 0.706 -0.209 3 0.775
MERTKMERTK 0.705 -0.186 3 0.770
TECTEC 0.705 -0.167 -1 0.653
FRKFRK 0.705 -0.148 -1 0.778
BTKBTK 0.704 -0.227 -1 0.689
ALKALK 0.703 -0.186 3 0.740
ERBB2ERBB2 0.703 -0.180 1 0.286
EPHA7EPHA7 0.702 -0.148 2 0.758
LYNLYN 0.701 -0.143 3 0.724
CK1G2CK1G2 0.701 -0.059 -3 0.475
MATKMATK 0.700 -0.118 -1 0.668
SRCSRC 0.700 -0.122 -1 0.746
FLT4FLT4 0.699 -0.188 3 0.746
LTKLTK 0.699 -0.208 3 0.747
EPHA3EPHA3 0.698 -0.177 2 0.729
PTK2PTK2 0.698 -0.061 -1 0.724
EGFREGFR 0.698 -0.124 1 0.231
INSRINSR 0.697 -0.201 3 0.735
EPHA1EPHA1 0.697 -0.199 3 0.770
PTK6PTK6 0.697 -0.247 -1 0.649
NTRK1NTRK1 0.696 -0.262 -1 0.743
PTK2BPTK2B 0.696 -0.145 -1 0.689
NTRK3NTRK3 0.695 -0.183 -1 0.702
EPHA8EPHA8 0.695 -0.132 -1 0.734
SYKSYK 0.695 -0.079 -1 0.723
FGFR4FGFR4 0.693 -0.123 -1 0.692
NTRK2NTRK2 0.692 -0.271 3 0.755
EPHA5EPHA5 0.692 -0.171 2 0.742
CSKCSK 0.692 -0.166 2 0.756
MUSKMUSK 0.690 -0.161 1 0.236
ERBB4ERBB4 0.689 -0.097 1 0.246
ZAP70ZAP70 0.684 -0.060 -1 0.644
EPHA2EPHA2 0.683 -0.151 -1 0.693
IGF1RIGF1R 0.681 -0.185 3 0.675
FESFES 0.667 -0.186 -1 0.616