Motif 1136 (n=112)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A8K4G0 | CD300LB | Y188 | psp | CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b) | Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. {ECO:0000269|PubMed:16920917, ECO:0000269|PubMed:17928527}. |
| O00264 | PGRMC1 | S181 | ochoa|psp | Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA) | Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021). {ECO:0000250|UniProtKB:O55022, ECO:0000269|PubMed:25675345, ECO:0000269|PubMed:27599036, ECO:0000269|PubMed:30443021, ECO:0000303|PubMed:28396637}. |
| O15173 | PGRMC2 | Y210 | ochoa | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). {ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}. |
| O15173 | PGRMC2 | T211 | ochoa | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). {ECO:0000250|UniProtKB:Q80UU9, ECO:0000269|PubMed:28111073, ECO:0000305|PubMed:28396637}. |
| O15541 | RNF113A | S329 | ochoa | E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106, PubMed:29361316). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). {ECO:0000269|PubMed:28978524, ECO:0000269|PubMed:29144457, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| O75347 | TBCA | Y94 | ochoa | Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) | Tubulin-folding protein; involved in the early step of the tubulin folding pathway. |
| O75971 | SNAPC5 | T85 | ochoa | snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. |
| O95049 | TJP3 | S906 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| P00338 | LDHA | S319 | ochoa|psp | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:11276087}. |
| P02794 | FTH1 | Y169 | ochoa | Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293). {ECO:0000250|UniProtKB:P09528, ECO:0000269|PubMed:24695223, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:9003196}. |
| P05114 | HMGN1 | S86 | ochoa|psp | Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1) | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}. |
| P05386 | RPLP1 | S101 | ochoa|psp | Large ribosomal subunit protein P1 (60S acidic ribosomal protein P1) | Plays an important role in the elongation step of protein synthesis. |
| P05387 | RPLP2 | S102 | ochoa|psp | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) (Renal carcinoma antigen NY-REN-44) | Plays an important role in the elongation step of protein synthesis. |
| P05388 | RPLP0 | S304 | ochoa|psp | Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. |
| P05556 | ITGB1 | S785 | ochoa|psp | Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) | Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed:35802072). {ECO:0000250|UniProtKB:P07228, ECO:0000250|UniProtKB:P09055, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:33962943, ECO:0000269|PubMed:35802072, ECO:0000269|PubMed:7523423}.; FUNCTION: [Isoform 2]: Interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). {ECO:0000305|PubMed:2249781}.; FUNCTION: [Isoform 5]: Isoform 5 displaces isoform 1 in striated muscles. {ECO:0000250|UniProtKB:P09055}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}.; FUNCTION: (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:20660204}.; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4. {ECO:0000269|PubMed:17945327}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:12907437}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus. {ECO:0000269|PubMed:16501085}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.; FUNCTION: (Microbial infection) Interacts with CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:32487760). Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression (PubMed:32487760). {ECO:0000269|PubMed:32487760}.; FUNCTION: (Microbial infection) May serve as a receptor for adhesin A (nadA) of N.meningitidis. {ECO:0000305|PubMed:21471204}.; FUNCTION: (Microbial infection) Facilitates rabies infection in a fibronectin-dependent manner and participates in rabies virus traffic after internalization. {ECO:0000269|PubMed:31666383}. |
| P06127 | CD5 | S482 | ochoa|psp | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
| P07195 | LDHB | S320 | ochoa | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
| P07951 | TPM2 | S271 | ochoa | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}. |
| P17612 | PRKACA | S339 | ochoa|psp | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}. |
| P22694 | PRKACB | S339 | ochoa | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}. |
| P23434 | GCSH | S160 | ochoa | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein) | The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST) (PubMed:36190515). {ECO:0000269|PubMed:1671321, ECO:0000269|PubMed:36190515}. |
| P25788 | PSMA3 | S243 | ochoa | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}. |
| P27348 | YWHAQ | S232 | ochoa|psp | 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}. |
| P33981 | TTK | S844 | ochoa | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P41208 | CETN2 | S158 | ochoa|psp | Centrin-2 (Caltractin isoform 1) | Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}. |
| P41212 | ETV6 | S439 | ochoa | Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel) | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}. |
| P41227 | NAA10 | S221 | ochoa | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821). {ECO:0000269|PubMed:12464182, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:19420222, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20145209, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:25489052, ECO:0000269|PubMed:27422821, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}. |
| P43246 | MSH2 | S921 | ochoa | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:17611581, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:26300262, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P43487 | RANBP1 | S188 | ochoa | Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) | Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}. |
| P46063 | RECQL | S636 | ochoa | ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1) | DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:15886194, PubMed:35025765, PubMed:7527136, PubMed:7961977, PubMed:8056767). Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:19151156, PubMed:35025765, PubMed:7527136, PubMed:8056767). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). Does not unwind G-quadruplex DNA (PubMed:18426915). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:15886194, PubMed:7961977). {ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:19151156, ECO:0000269|PubMed:25831490, ECO:0000269|PubMed:35025765, ECO:0000269|PubMed:7527136, ECO:0000269|PubMed:7961977, ECO:0000269|PubMed:8056767}. |
| P49427 | CDC34 | S222 | psp | Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) | E2 ubiquitin-conjugating enzyme that accepts ubiquitin from an E1 ubiquitin-activating protein, and catalyzes its covalent attachment to other proteins by an E3 ubiquitin-protein ligase complex (PubMed:10329681, PubMed:17588522, PubMed:20061386, PubMed:38326650). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation (PubMed:10329681, PubMed:10918611, PubMed:17698585). Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1 (PubMed:10871850, PubMed:15652359, PubMed:19112177). Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation (PubMed:19126550). Also involved in the degradation of beta-catenin (PubMed:12037680). Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:11805320, PubMed:12060736). {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:10871850, ECO:0000269|PubMed:10918611, ECO:0000269|PubMed:11805320, ECO:0000269|PubMed:12037680, ECO:0000269|PubMed:12060736, ECO:0000269|PubMed:15652359, ECO:0000269|PubMed:17588522, ECO:0000269|PubMed:17698585, ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:19126550, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:38326650}. |
| P51681 | CCR5 | Y339 | psp | C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195) | Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770). {ECO:0000269|PubMed:10383387, ECO:0000269|PubMed:11323418, ECO:0000269|PubMed:30713770, ECO:0000269|PubMed:8639485, ECO:0000269|PubMed:8663314, ECO:0000269|PubMed:8699119}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. {ECO:0000269|PubMed:10383387, ECO:0000269|PubMed:21763489, ECO:0000269|PubMed:8649511, ECO:0000269|PubMed:8649512, ECO:0000269|PubMed:9632396}. |
| P53567 | CEBPG | S137 | ochoa | CCAAT/enhancer-binding protein gamma (C/EBP gamma) | Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. {ECO:0000250|UniProtKB:P26801, ECO:0000250|UniProtKB:P53568, ECO:0000269|PubMed:7665092}. |
| P55010 | EIF5 | S419 | ochoa | Eukaryotic translation initiation factor 5 (eIF-5) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}. |
| P61981 | YWHAG | S235 | ochoa | 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927). {ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:22532927, ECO:0000269|PubMed:29121962, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:36732624}. |
| P62328 | TMSB4X | S31 | ochoa | Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hemoregulatory peptide AcSDKP (Ac-Ser-Asp-Lys-Pro) (N-acetyl-SDKP) (AcSDKP) (Seraspenide)] | Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398). {ECO:0000269|PubMed:10848969, ECO:0000269|PubMed:1999398}.; FUNCTION: [Hemoregulatory peptide AcSDKP]: Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity). {ECO:0000250|UniProtKB:P62326, ECO:0000269|PubMed:7694679}. |
| P63104 | YWHAZ | T232 | ochoa|psp | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}. |
| P68363 | TUBA1B | S439 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P82909 | KGD4 | S90 | ochoa | Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4) | Molecular adapter that is necessary to form a stable 2-oxoglutarate dehydrogenase enzyme complex (OGDHC). Enables the specific recruitment of E3 subunit to E2 subunit in the 2-oxoglutarate dehydrogenase complex (OGDHC). {ECO:0000250|UniProtKB:Q9CQX8}. |
| P83916 | CBX1 | S172 | ochoa | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}. |
| P84157 | MXRA7 | S191 | ochoa | Matrix-remodeling-associated protein 7 | None |
| P98088 | MUC5AC | S5641 | ochoa | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). {ECO:0000269|PubMed:14535999, ECO:0000303|PubMed:14535999, ECO:0000303|PubMed:14718370}. |
| Q02790 | FKBP4 | S446 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q02880 | TOP2B | S1613 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q12908 | SLC10A2 | S335 | psp | Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2) | Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321). {ECO:0000269|PubMed:7592981, ECO:0000269|PubMed:9458785, ECO:0000269|PubMed:9856990, ECO:0000303|PubMed:33222321, ECO:0000305|PubMed:9458785}. |
| Q13164 | MAPK7 | S803 | psp | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q14696 | MESD | S221 | ochoa | LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61) | Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) (PubMed:15014448). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane (PubMed:17488095, PubMed:23572575). Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity). {ECO:0000250|UniProtKB:Q9ERE7, ECO:0000269|PubMed:15014448, ECO:0000269|PubMed:17488095, ECO:0000269|PubMed:23572575}. |
| Q14814 | MEF2D | S508 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q15084 | PDIA6 | S428 | ochoa|psp | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q15109 | AGER | S391 | ochoa|psp | Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) | Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, histones, phospholipids and glycosaminoglycans (PubMed:27572515, PubMed:28515150, PubMed:34743181, PubMed:35974093, PubMed:24081950). Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed:21565706). These ligands accumulate at inflammatory sites during the pathogenesis of various diseases including diabetes, vascular complications, neurodegenerative disorders and cancers, and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction of inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B (PubMed:21829704, PubMed:33436632). Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (PubMed:19386136). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed:19906677). ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (PubMed:27572515). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (PubMed:34743181). Binds to DNA and promotes extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (PubMed:24081950, PubMed:28515150). Mediates phagocytosis by non-professional phagocytes (NPP) and this is enhanced by binding to ligands including RNA, DNA, HMGB1 and histones (PubMed:35974093). Promotes NPP-mediated phagocytosis of Saccharomyces cerevisiae spores by binding to RNA attached to the spore wall (PubMed:35974093). Also promotes NPP-mediated phagocytosis of apoptotic cells (PubMed:35974093). Following DNA damage, recruited to DNA double-strand break sites where it colocalizes with the MRN repair complex via interaction with double-strand break repair protein MRE11 (By similarity). Enhances the endonuclease activity of MRE11, promoting the end resection of damaged DNA (By similarity). Promotes DNA damage repair in trophoblasts which enhances trophoblast invasion and contributes to placental development and maintenance (PubMed:33918759). Protects cells from DNA replication stress by localizing to damaged replication forks where it stabilizes the MCM2-7 complex and promotes faithful progression of the replication fork (PubMed:36807739). Mediates the production of reactive oxygen species (ROS) in human endothelial cells (PubMed:25401185). {ECO:0000250|UniProtKB:Q62151, ECO:0000269|PubMed:19906677, ECO:0000269|PubMed:20943659, ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:21565706, ECO:0000269|PubMed:21829704, ECO:0000269|PubMed:24081950, ECO:0000269|PubMed:25401185, ECO:0000269|PubMed:27572515, ECO:0000269|PubMed:28515150, ECO:0000269|PubMed:33436632, ECO:0000269|PubMed:33918759, ECO:0000269|PubMed:34743181, ECO:0000269|PubMed:35974093, ECO:0000269|PubMed:36807739}. |
| Q16533 | SNAPC1 | S355 | ochoa | snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Proximal sequence element-binding transcription factor subunit gamma) (PSE-binding factor subunit gamma) (PTF subunit gamma) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) | Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. {ECO:0000269|PubMed:12621023}. |
| Q49A26 | GLYR1 | S540 | ochoa | Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1) | Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}. |
| Q504Q3 | PAN2 | S1189 | ochoa | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255|HAMAP-Rule:MF_03182, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:16284618, ECO:0000269|PubMed:23398456}. |
| Q53FP2 | TMEM35A | S154 | ochoa | Novel acetylcholine receptor chaperone | Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (PubMed:32676916). {ECO:0000250|UniProtKB:Q9D328, ECO:0000269|PubMed:26875622, ECO:0000269|PubMed:27789755, ECO:0000269|PubMed:28445721, ECO:0000269|PubMed:32204458, ECO:0000269|PubMed:32676916, ECO:0000269|PubMed:32783947}. |
| Q58WW2 | DCAF6 | S847 | ochoa | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
| Q5JQS6 | GCSAML | S122 | ochoa | Germinal center-associated signaling and motility-like protein | None |
| Q641Q2 | WASHC2A | S1328 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6P9B6 | MEAK7 | S443 | ochoa | MTOR-associated protein MEAK7 (MEAK7) (MTOR associated protein, eak-7 homolog) (TBC/LysM-associated domain-containing protein 1) (TLD domain-containing protein 1) | Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (PubMed:29750193). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (PubMed:29750193). {ECO:0000269|PubMed:29750193}. |
| Q6ZSS7 | MFSD6 | S779 | ochoa | Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) | None |
| Q71U36 | TUBA1A | S439 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7L2Z9 | CENPQ | S255 | psp | Centromere protein Q (CENP-Q) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}. |
| Q7Z4H7 | HAUS6 | S943 | ochoa | HAUS augmin-like complex subunit 6 | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}. |
| Q7Z7N9 | TMEM179B | S205 | ochoa | Transmembrane protein 179B | None |
| Q7Z7N9 | TMEM179B | S206 | ochoa | Transmembrane protein 179B | None |
| Q86VR2 | RETREG3 | S453 | ochoa | Reticulophagy regulator 3 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}. |
| Q86WV6 | STING1 | S366 | psp | Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23747010, PubMed:23910378, PubMed:27801882, PubMed:29973723, PubMed:30842659, PubMed:35045565, PubMed:35388221, PubMed:36808561, PubMed:37832545, PubMed:25704810, PubMed:39255680). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:26300263). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, cyclic UMP-AMP (2',3'-cUAMP), and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:21947006, PubMed:23258412, PubMed:23707065, PubMed:23722158, PubMed:23747010, PubMed:23910378, PubMed:26229117, PubMed:30842659, PubMed:35388221, PubMed:37379839). Upon binding to c-di-GMP, cUAMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:22394562, PubMed:25636800, PubMed:29973723, PubMed:30842653, PubMed:35045565, PubMed:35388221). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:23747010, PubMed:23910378, PubMed:26300263). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation (PubMed:26150511). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30568238, PubMed:30842662). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed:30842662). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (PubMed:30842662). Promotes autophagy by acting as a proton channel that directs proton efflux from the Golgi to facilitate MAP1LC3B/LC3B lipidation (PubMed:37535724). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (PubMed:30568238, PubMed:30842662). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (PubMed:18724357). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity). {ECO:0000250|UniProtKB:Q3TBT3, ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740, ECO:0000269|PubMed:21947006, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:23258412, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722158, ECO:0000269|PubMed:23747010, ECO:0000269|PubMed:23910378, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:26150511, ECO:0000269|PubMed:26229117, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29973723, ECO:0000269|PubMed:30568238, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35388221, ECO:0000269|PubMed:36808561, ECO:0000269|PubMed:37379839, ECO:0000269|PubMed:37535724, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:39255680}.; FUNCTION: (Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230). {ECO:0000269|PubMed:26405230}. |
| Q8N2Z9 | CENPS | S125 | ochoa | Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1) (FANCM-associated histone fold protein 1) (FANCM-interacting histone fold protein 1) (Fanconi anemia-associated polypeptide of 16 kDa) | DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917). DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347428, PubMed:20347429). {ECO:0000269|PubMed:19620631, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429, ECO:0000269|PubMed:22304917}. |
| Q8N5S9 | CAMKK1 | S492 | ochoa | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Q8N9B5 | JMY | S974 | ochoa | Junction-mediating and -regulatory protein | Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity). {ECO:0000250|UniProtKB:Q9QXM1, ECO:0000269|PubMed:30420355}. |
| Q8N9N8 | EIF1AD | Y152 | ochoa | Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) (Haponin) | Plays a role into cellular response to oxidative stress. Decreases cell proliferation. {ECO:0000269|PubMed:20644585, ECO:0000269|PubMed:22095125}. |
| Q8NHW5 | RPLP0P6 | S304 | ochoa | Putative ribosomal protein uL10-like (60S acidic ribosomal protein P0-like) (Large ribosomal subunit protein uL10-like) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. {ECO:0000250}. |
| Q8TEA8 | DTD1 | S196 | ochoa|psp | D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related) | Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269|PubMed:15653697, ECO:0000269|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250|UniProtKB:Q8IIS0}. |
| Q8WYR4 | RSPH1 | S297 | ochoa | Radial spoke head 1 homolog (Cancer/testis antigen 79) (CT79) (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) | Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. {ECO:0000269|PubMed:23993197}. |
| Q92541 | RTF1 | S697 | ochoa | RNA polymerase-associated protein RTF1 homolog | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Binds single-stranded DNA. Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:20178742}. |
| Q96A19 | CCDC102A | S537 | ochoa | Coiled-coil domain-containing protein 102A | None |
| Q96D46 | NMD3 | S490 | ochoa | 60S ribosomal export protein NMD3 (hNMD3) | Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}. |
| Q96KA5 | CLPTM1L | S526 | ochoa | Lipid scramblase CLPTM1L (Cisplatin resistance-related protein 9) (CRR9p) (Cleft lip and palate transmembrane protein 1-like protein) (CLPTM1-like protein) | Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI) (PubMed:35344438). GPI is a lipid glycoconjugate involved in post-translational modification of proteins (PubMed:35344438). Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro (PubMed:35344438). {ECO:0000269|PubMed:35344438}. |
| Q96QK1 | VPS35 | S783 | ochoa | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:30213940). The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of WASHC2C (PubMed:22070227, PubMed:28892079). Mediates the association of the CSC with the WASH complex via WASHC2 (PubMed:22070227, PubMed:24819384, PubMed:24980502). Required for the endosomal localization of TBC1D5 (PubMed:20923837). {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:20164305, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24819384, ECO:0000269|PubMed:24980502, ECO:0000269|PubMed:28892079, ECO:0000269|PubMed:30213940, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:22070227, ECO:0000303|PubMed:22513087, ECO:0000303|PubMed:23563491}.; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. {ECO:0000269|PubMed:25693203, ECO:0000269|PubMed:30122350}. |
| Q96RE7 | NACC1 | S514 | ochoa | Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B) | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}. |
| Q99623 | PHB2 | S286 | ochoa | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:11302691, PubMed:20959514). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:11302691, PubMed:20959514). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}. |
| Q9BPX3 | NCAPG | S1002 | ochoa | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Q9BQA9 | CYBC1 | S173 | ochoa | Cytochrome b-245 chaperone 1 (Essential for reactive oxygen species protein) (Eros) | Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (PubMed:30361506). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity). {ECO:0000250|UniProtKB:Q3TYS2, ECO:0000269|PubMed:30361506}. |
| Q9BQA9 | CYBC1 | S175 | ochoa | Cytochrome b-245 chaperone 1 (Essential for reactive oxygen species protein) (Eros) | Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (PubMed:30361506). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity). {ECO:0000250|UniProtKB:Q3TYS2, ECO:0000269|PubMed:30361506}. |
| Q9BYX2 | TBC1D2 | S915 | ochoa | TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) | Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}. |
| Q9H2U2 | PPA2 | S322 | ochoa | Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2) | Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598). {ECO:0000269|PubMed:27523597, ECO:0000269|PubMed:27523598}. |
| Q9H4B7 | TUBB1 | T439 | ochoa | Tubulin beta-1 chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9H832 | UBE2Z | S341 | ochoa | Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z) | Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. {ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:17464193, ECO:0000269|PubMed:17597759}. |
| Q9HD43 | PTPRH | Y1102 | ochoa | Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H) | Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity). {ECO:0000250|UniProtKB:E9Q0N2, ECO:0000269|PubMed:11278335, ECO:0000269|PubMed:12101188, ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:15850787}. |
| Q9NWQ8 | PAG1 | S419 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9P2D1 | CHD7 | S2983 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9UBI6 | GNG12 | S59 | ochoa | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Q9UGP8 | SEC63 | S748 | psp | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UHD2 | TBK1 | S716 | ochoa|psp | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UKG1 | APPL1 | S696 | ochoa | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:10490823, PubMed:15016378, PubMed:19661063, PubMed:26073777, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways (PubMed:19661063, PubMed:24879834, PubMed:26073777). Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). {ECO:0000250|UniProtKB:Q8K3H0, ECO:0000269|PubMed:10490823, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26073777, ECO:0000269|PubMed:26583432}. |
| Q9UKM9 | RALY | S295 | ochoa|psp | RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog) | RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}. |
| Q9UPI3 | FLVCR2 | S512 | ochoa | Choline/ethanolamine transporter FLVCR2 (Calcium-chelate transporter) (CCT) (Feline leukemia virus subgroup C receptor-related protein 2) (Heme transporter FLVCR2) | Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier (PubMed:38302740, PubMed:38778100). Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (By similarity). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (By similarity). Also mediates transport of ethanolamine (PubMed:38778100). Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane (PubMed:38778100). However, the presence of an inwardly directed proton gradient enhances choline uptake (By similarity). Also acts as a heme b transporter (PubMed:20823265, PubMed:32973183). Required to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis (PubMed:32973183). At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis (PubMed:32973183). Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis (PubMed:32973183). {ECO:0000250|UniProtKB:Q91X85, ECO:0000269|PubMed:20823265, ECO:0000269|PubMed:32973183, ECO:0000269|PubMed:38302740, ECO:0000269|PubMed:38778100}. |
| Q9UPI3 | FLVCR2 | S515 | ochoa | Choline/ethanolamine transporter FLVCR2 (Calcium-chelate transporter) (CCT) (Feline leukemia virus subgroup C receptor-related protein 2) (Heme transporter FLVCR2) | Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier (PubMed:38302740, PubMed:38778100). Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain (By similarity). Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine (By similarity). Also mediates transport of ethanolamine (PubMed:38778100). Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane (PubMed:38778100). However, the presence of an inwardly directed proton gradient enhances choline uptake (By similarity). Also acts as a heme b transporter (PubMed:20823265, PubMed:32973183). Required to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis (PubMed:32973183). At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis (PubMed:32973183). Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis (PubMed:32973183). {ECO:0000250|UniProtKB:Q91X85, ECO:0000269|PubMed:20823265, ECO:0000269|PubMed:32973183, ECO:0000269|PubMed:38302740, ECO:0000269|PubMed:38778100}. |
| Q9Y3F4 | STRAP | S335 | ochoa | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}. |
| Q9Y5S1 | TRPV2 | S751 | ochoa | Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF1, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. {ECO:0000269|PubMed:10201375}. |
| Q14257 | RCN2 | Y303 | Sugiyama | Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP) | Not known. Binds calcium. |
| Q9BS26 | ERP44 | S393 | Sugiyama | Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:14517240, PubMed:29858230). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230). {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240, ECO:0000269|PubMed:15652484, ECO:0000269|PubMed:29858230}. |
| Q96FW1 | OTUB1 | Y258 | Sugiyama | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (PubMed:12401499, PubMed:12704427, PubMed:14661020, PubMed:23827681). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy (PubMed:14661020). Isoform 1 destabilizes RNF128, leading to prevent anergy (PubMed:14661020). In contrast, isoform 2 stabilizes RNF128 and promotes anergy (PubMed:14661020). Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (PubMed:14661020). Deubiquitinates estrogen receptor alpha (ESR1) (PubMed:19383985). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (PubMed:18954305, PubMed:19211026, PubMed:23827681). Not able to cleave di-ubiquitin (PubMed:18954305, PubMed:23827681). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (PubMed:18954305, PubMed:23827681). {ECO:0000269|PubMed:12401499, ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:14661020, ECO:0000269|PubMed:18954305, ECO:0000269|PubMed:19211026, ECO:0000269|PubMed:19383985, ECO:0000269|PubMed:23827681}.; FUNCTION: Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites (PubMed:20725033, PubMed:22325355). Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of 'Lys-63'-linked histone H2A and H2AX marks (PubMed:20725033, PubMed:22325355). Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1 (PubMed:20725033, PubMed:22325355). The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved 'Lys48'-linked di-ubiquitin chain (PubMed:20725033, PubMed:22325355). Acts as a regulator of mTORC1 and mTORC2 complexes (PubMed:29382726, PubMed:35927303). When phosphorylated at Tyr-26, acts as an activator of the mTORC1 complex by mediating deubiquitination of RPTOR via a non-catalytic process: acts by binding and inhibiting the activity of the ubiquitin-conjugating enzyme E2 (UBE2D1/UBCH5A, UBE2W/UBC16 and UBE2N/UBC13), thereby preventing ubiquitination of RPTOR (PubMed:35927303). Can also act as an inhibitor of the mTORC1 and mTORC2 complexes in response to amino acids by mediating non-catalytic deubiquitination of DEPTOR (PubMed:29382726). {ECO:0000269|PubMed:20725033, ECO:0000269|PubMed:22325355, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:35927303}. |
| Q9Y2T3 | GDA | Y441 | Sugiyama | Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin) | Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. {ECO:0000269|PubMed:10075721, ECO:0000269|PubMed:22662200}. |
| Q10567 | AP1B1 | S936 | Sugiyama | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:31630791}. |
| P07108 | DBI | Y74 | Sugiyama | Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) | Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. |
| P01350 | GAST | Y87 | GPS6|ELM|iPTMNet|EPSD | Gastrin [Cleaved into: Gastrin-71 (Gastrin component I); Gastrin-52 (G52); Big gastrin (Gastrin component II) (Gastrin-34) (G34); Gastrin (Gastrin component III) (Gastrin-17) (G17); Gastrin-14 (G14); Gastrin-6 (G6)] | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. |
| Q16401 | PSMD5 | Y491 | Sugiyama | 26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B) | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5. {ECO:0000269|PubMed:19412159, ECO:0000269|PubMed:19490896}. |
| O14958 | CASQ2 | S385 | SIGNOR|iPTMNet | Calsequestrin-2 (Calsequestrin, cardiac muscle isoform) | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16908766, ECO:0000269|PubMed:17881003, ECO:0000269|PubMed:18399795, ECO:0000269|PubMed:21416293}. |
| P40925 | MDH1 | T321 | Sugiyama | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P15927 | RPA2 | Y256 | Sugiyama | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P15927 | RPA2 | S257 | Sugiyama | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA stimulates 5'-3' helicase activity of BRIP1/FANCJ (PubMed:17596542). {ECO:0000269|PubMed:15205463, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:17765923, ECO:0000269|PubMed:17959650, ECO:0000269|PubMed:19116208, ECO:0000269|PubMed:20154705, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:2406247, ECO:0000269|PubMed:24332808, ECO:0000269|PubMed:7697716, ECO:0000269|PubMed:7700386, ECO:0000269|PubMed:8702565, ECO:0000269|PubMed:9430682, ECO:0000269|PubMed:9765279}. |
| P60174 | TPI1 | S236 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.000002 | 5.677 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.000014 | 4.864 |
| R-HSA-68877 | Mitotic Prometaphase | 0.000008 | 5.093 |
| R-HSA-111933 | Calmodulin induced events | 0.000026 | 4.580 |
| R-HSA-111997 | CaM pathway | 0.000026 | 4.580 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.000013 | 4.892 |
| R-HSA-8853659 | RET signaling | 0.000026 | 4.580 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.000032 | 4.493 |
| R-HSA-163358 | PKA-mediated phosphorylation of key metabolic factors | 0.000039 | 4.409 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.000036 | 4.445 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.000052 | 4.288 |
| R-HSA-392517 | Rap1 signalling | 0.000044 | 4.356 |
| R-HSA-111996 | Ca-dependent events | 0.000054 | 4.271 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.000050 | 4.303 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.000070 | 4.153 |
| R-HSA-9634597 | GPER1 signaling | 0.000091 | 4.041 |
| R-HSA-68886 | M Phase | 0.000090 | 4.043 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.000103 | 3.987 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.000117 | 3.933 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 0.000202 | 3.694 |
| R-HSA-112043 | PLC beta mediated events | 0.000238 | 3.623 |
| R-HSA-69275 | G2/M Transition | 0.000242 | 3.617 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.000258 | 3.589 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.000250 | 3.602 |
| R-HSA-1640170 | Cell Cycle | 0.000213 | 3.672 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.000236 | 3.627 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.000271 | 3.567 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.000271 | 3.567 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.000327 | 3.485 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 0.000308 | 3.511 |
| R-HSA-111885 | Opioid Signalling | 0.000328 | 3.484 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.000356 | 3.449 |
| R-HSA-112040 | G-protein mediated events | 0.000348 | 3.459 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.000356 | 3.449 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.000409 | 3.388 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.000492 | 3.308 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.000491 | 3.309 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 0.000491 | 3.309 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 0.000491 | 3.309 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 0.000491 | 3.309 |
| R-HSA-8963896 | HDL assembly | 0.000420 | 3.377 |
| R-HSA-380287 | Centrosome maturation | 0.000549 | 3.260 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 0.000569 | 3.245 |
| R-HSA-422475 | Axon guidance | 0.000565 | 3.248 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.000655 | 3.184 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.000658 | 3.182 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.000658 | 3.182 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.000658 | 3.182 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.000709 | 3.149 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.000749 | 3.125 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 0.000752 | 3.124 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.000879 | 3.056 |
| R-HSA-163615 | PKA activation | 0.000851 | 3.070 |
| R-HSA-164378 | PKA activation in glucagon signalling | 0.000851 | 3.070 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.000879 | 3.056 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.000851 | 3.070 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.000869 | 3.061 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.000961 | 3.017 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.000961 | 3.017 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.001007 | 2.997 |
| R-HSA-9675108 | Nervous system development | 0.001008 | 2.997 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.001200 | 2.921 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.001208 | 2.918 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 0.001458 | 2.836 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 0.001458 | 2.836 |
| R-HSA-391251 | Protein folding | 0.001368 | 2.864 |
| R-HSA-5617833 | Cilium Assembly | 0.001431 | 2.844 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.001679 | 2.775 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.001814 | 2.741 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.001814 | 2.741 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.001814 | 2.741 |
| R-HSA-422356 | Regulation of insulin secretion | 0.001825 | 2.739 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.002298 | 2.639 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.002292 | 2.640 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.002374 | 2.625 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.002414 | 2.617 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.002566 | 2.591 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.002581 | 2.588 |
| R-HSA-180024 | DARPP-32 events | 0.002800 | 2.553 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.002855 | 2.544 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.003235 | 2.490 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.003030 | 2.519 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.003270 | 2.485 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.003370 | 2.472 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.003389 | 2.470 |
| R-HSA-2262752 | Cellular responses to stress | 0.003402 | 2.468 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.003787 | 2.422 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.004526 | 2.344 |
| R-HSA-190861 | Gap junction assembly | 0.004350 | 2.362 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.004229 | 2.374 |
| R-HSA-8852135 | Protein ubiquitination | 0.004412 | 2.355 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.004147 | 2.382 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.004582 | 2.339 |
| R-HSA-9824446 | Viral Infection Pathways | 0.004034 | 2.394 |
| R-HSA-163560 | Triglyceride catabolism | 0.004961 | 2.304 |
| R-HSA-449147 | Signaling by Interleukins | 0.005225 | 2.282 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.005411 | 2.267 |
| R-HSA-9833482 | PKR-mediated signaling | 0.005411 | 2.267 |
| R-HSA-69481 | G2/M Checkpoints | 0.005580 | 2.253 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.005760 | 2.240 |
| R-HSA-9646399 | Aggrephagy | 0.006333 | 2.198 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.006550 | 2.184 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.006772 | 2.169 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.007095 | 2.149 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.007305 | 2.136 |
| R-HSA-163685 | Integration of energy metabolism | 0.007572 | 2.121 |
| R-HSA-9663891 | Selective autophagy | 0.007569 | 2.121 |
| R-HSA-190828 | Gap junction trafficking | 0.008336 | 2.079 |
| R-HSA-437239 | Recycling pathway of L1 | 0.009698 | 2.013 |
| R-HSA-5620924 | Intraflagellar transport | 0.010178 | 1.992 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.010229 | 1.990 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.010673 | 1.972 |
| R-HSA-68882 | Mitotic Anaphase | 0.011399 | 1.943 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.011618 | 1.935 |
| R-HSA-70171 | Glycolysis | 0.011938 | 1.923 |
| R-HSA-6783984 | Glycine degradation | 0.012214 | 1.913 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.013337 | 1.875 |
| R-HSA-5358508 | Mismatch Repair | 0.014503 | 1.839 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.013337 | 1.875 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.013431 | 1.872 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 0.014503 | 1.839 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.013930 | 1.856 |
| R-HSA-109581 | Apoptosis | 0.014452 | 1.840 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.014522 | 1.838 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.012602 | 1.900 |
| R-HSA-5663205 | Infectious disease | 0.014799 | 1.830 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.015457 | 1.811 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.015651 | 1.805 |
| R-HSA-5632927 | Defective Mismatch Repair Associated With MSH3 | 0.015651 | 1.805 |
| R-HSA-112316 | Neuronal System | 0.015789 | 1.802 |
| R-HSA-8979227 | Triglyceride metabolism | 0.016381 | 1.786 |
| R-HSA-983189 | Kinesins | 0.017030 | 1.769 |
| R-HSA-418555 | G alpha (s) signalling events | 0.017811 | 1.749 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.019289 | 1.715 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.019568 | 1.708 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.020063 | 1.698 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.020063 | 1.698 |
| R-HSA-373760 | L1CAM interactions | 0.020063 | 1.698 |
| R-HSA-70326 | Glucose metabolism | 0.020565 | 1.687 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.020953 | 1.679 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.020953 | 1.679 |
| R-HSA-1280218 | Adaptive Immune System | 0.021276 | 1.672 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.023385 | 1.631 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.022363 | 1.650 |
| R-HSA-72766 | Translation | 0.026721 | 1.573 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.024296 | 1.614 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.023741 | 1.625 |
| R-HSA-3000170 | Syndecan interactions | 0.022363 | 1.650 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.025921 | 1.586 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.025101 | 1.600 |
| R-HSA-194138 | Signaling by VEGF | 0.025434 | 1.595 |
| R-HSA-525793 | Myogenesis | 0.026817 | 1.572 |
| R-HSA-168256 | Immune System | 0.027229 | 1.565 |
| R-HSA-9609690 | HCMV Early Events | 0.028363 | 1.547 |
| R-HSA-198765 | Signalling to ERK5 | 0.031058 | 1.508 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 0.031058 | 1.508 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.031597 | 1.500 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.032989 | 1.482 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.033259 | 1.478 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.033259 | 1.478 |
| R-HSA-5357801 | Programmed Cell Death | 0.033498 | 1.475 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.034978 | 1.456 |
| R-HSA-1632852 | Macroautophagy | 0.037105 | 1.431 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.038672 | 1.413 |
| R-HSA-8875513 | MET interacts with TNS proteins | 0.038672 | 1.413 |
| R-HSA-392499 | Metabolism of proteins | 0.038928 | 1.410 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.053722 | 1.270 |
| R-HSA-9022535 | Loss of phosphorylation of MECP2 at T308 | 0.053722 | 1.270 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.045274 | 1.344 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.046387 | 1.334 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.050973 | 1.293 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.053631 | 1.271 |
| R-HSA-3371568 | Attenuation phase | 0.053631 | 1.271 |
| R-HSA-156902 | Peptide chain elongation | 0.042016 | 1.377 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.052153 | 1.283 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.052153 | 1.283 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.047513 | 1.323 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.053631 | 1.271 |
| R-HSA-418594 | G alpha (i) signalling events | 0.053639 | 1.271 |
| R-HSA-9711097 | Cellular response to starvation | 0.051402 | 1.289 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.045803 | 1.339 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.045803 | 1.339 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.053346 | 1.273 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.053346 | 1.273 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.046344 | 1.334 |
| R-HSA-3371511 | HSF1 activation | 0.045803 | 1.339 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.047395 | 1.324 |
| R-HSA-9612973 | Autophagy | 0.049683 | 1.304 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.047997 | 1.319 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.047513 | 1.323 |
| R-HSA-109582 | Hemostasis | 0.053988 | 1.268 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.055657 | 1.254 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.057004 | 1.244 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.059507 | 1.225 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.059789 | 1.223 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.059789 | 1.223 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.061893 | 1.208 |
| R-HSA-192823 | Viral mRNA Translation | 0.062062 | 1.207 |
| R-HSA-9609646 | HCMV Infection | 0.063471 | 1.197 |
| R-HSA-9907900 | Proteasome assembly | 0.064023 | 1.194 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.065988 | 1.181 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.066177 | 1.179 |
| R-HSA-774815 | Nucleosome assembly | 0.066177 | 1.179 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.066177 | 1.179 |
| R-HSA-168249 | Innate Immune System | 0.066201 | 1.179 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.066307 | 1.178 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.066307 | 1.178 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.067790 | 1.169 |
| R-HSA-9675135 | Diseases of DNA repair | 0.068355 | 1.165 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.068667 | 1.163 |
| R-HSA-114516 | Disinhibition of SNARE formation | 0.075860 | 1.120 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.111620 | 0.952 |
| R-HSA-202670 | ERKs are inactivated | 0.111620 | 0.952 |
| R-HSA-9853506 | OGDH complex synthesizes succinyl-CoA from 2-OG | 0.125537 | 0.901 |
| R-HSA-9857492 | Protein lipoylation | 0.139237 | 0.856 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 0.139237 | 0.856 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.146007 | 0.836 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 0.146007 | 0.836 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 0.146007 | 0.836 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.152725 | 0.816 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.152725 | 0.816 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 0.159389 | 0.798 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.166002 | 0.780 |
| R-HSA-418217 | G beta:gamma signalling through PLC beta | 0.166002 | 0.780 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.191941 | 0.717 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 0.204609 | 0.689 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.170030 | 0.769 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.170030 | 0.769 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.172825 | 0.762 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.164466 | 0.784 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.152725 | 0.816 |
| R-HSA-202040 | G-protein activation | 0.185532 | 0.732 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.075579 | 1.122 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.139237 | 0.856 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.075579 | 1.122 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.083125 | 1.080 |
| R-HSA-173107 | Binding and entry of HIV virion | 0.097484 | 1.011 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.132414 | 0.878 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.159389 | 0.798 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.172563 | 0.763 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 0.185532 | 0.732 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.084231 | 1.075 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.083125 | 1.080 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.111620 | 0.952 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.166002 | 0.780 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.079587 | 1.099 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.131880 | 0.880 |
| R-HSA-8949664 | Processing of SMDT1 | 0.125537 | 0.901 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 0.172563 | 0.763 |
| R-HSA-198753 | ERK/MAPK targets | 0.185532 | 0.732 |
| R-HSA-418597 | G alpha (z) signalling events | 0.088955 | 1.051 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.131880 | 0.880 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.090332 | 1.044 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 0.118606 | 0.926 |
| R-HSA-1566977 | Fibronectin matrix formation | 0.152725 | 0.816 |
| R-HSA-500657 | Presynaptic function of Kainate receptors | 0.166002 | 0.780 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 0.204609 | 0.689 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.152725 | 0.816 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.090332 | 1.044 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.139237 | 0.856 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.166002 | 0.780 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.111620 | 0.952 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.152725 | 0.816 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.090332 | 1.044 |
| R-HSA-388396 | GPCR downstream signalling | 0.098342 | 1.007 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.172563 | 0.763 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.097484 | 1.011 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.166002 | 0.780 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.185532 | 0.732 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.070026 | 1.155 |
| R-HSA-3371556 | Cellular response to heat stress | 0.091808 | 1.037 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.083125 | 1.080 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 0.191941 | 0.717 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.204609 | 0.689 |
| R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.152725 | 0.816 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.185532 | 0.732 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.201139 | 0.697 |
| R-HSA-3238698 | WNT ligand biogenesis and trafficking | 0.198300 | 0.703 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.097484 | 1.011 |
| R-HSA-416476 | G alpha (q) signalling events | 0.187175 | 0.728 |
| R-HSA-4086398 | Ca2+ pathway | 0.134535 | 0.871 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.112668 | 0.948 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.203169 | 0.692 |
| R-HSA-447041 | CHL1 interactions | 0.075860 | 1.120 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 0.090332 | 1.044 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.118606 | 0.926 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.118606 | 0.926 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.118606 | 0.926 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 0.146007 | 0.836 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.146007 | 0.836 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.159389 | 0.798 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.101221 | 0.995 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.170030 | 0.769 |
| R-HSA-73886 | Chromosome Maintenance | 0.091808 | 1.037 |
| R-HSA-5578775 | Ion homeostasis | 0.091347 | 1.039 |
| R-HSA-372790 | Signaling by GPCR | 0.156094 | 0.807 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 0.090332 | 1.044 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.152725 | 0.816 |
| R-HSA-9707616 | Heme signaling | 0.106074 | 0.974 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 0.075028 | 1.125 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.121133 | 0.917 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.185532 | 0.732 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.204609 | 0.689 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.137203 | 0.863 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.096467 | 1.016 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.072778 | 1.138 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.090332 | 1.044 |
| R-HSA-9856872 | Malate-aspartate shuttle | 0.132414 | 0.878 |
| R-HSA-9830674 | Formation of the ureteric bud | 0.204609 | 0.689 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.157145 | 0.804 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.188037 | 0.726 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.072778 | 1.138 |
| R-HSA-597592 | Post-translational protein modification | 0.171218 | 0.766 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 0.125537 | 0.901 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.132414 | 0.878 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.131880 | 0.880 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.071396 | 1.146 |
| R-HSA-69306 | DNA Replication | 0.153403 | 0.814 |
| R-HSA-195721 | Signaling by WNT | 0.107883 | 0.967 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.147986 | 0.830 |
| R-HSA-416700 | Other semaphorin interactions | 0.139237 | 0.856 |
| R-HSA-199991 | Membrane Trafficking | 0.083219 | 1.080 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.139237 | 0.856 |
| R-HSA-210991 | Basigin interactions | 0.185532 | 0.732 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.144178 | 0.841 |
| R-HSA-70268 | Pyruvate metabolism | 0.175626 | 0.755 |
| R-HSA-180292 | GAB1 signalosome | 0.166002 | 0.780 |
| R-HSA-445144 | Signal transduction by L1 | 0.179073 | 0.747 |
| R-HSA-162906 | HIV Infection | 0.132184 | 0.879 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.191941 | 0.717 |
| R-HSA-4086400 | PCP/CE pathway | 0.147986 | 0.830 |
| R-HSA-202424 | Downstream TCR signaling | 0.184075 | 0.735 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.147845 | 0.830 |
| R-HSA-202403 | TCR signaling | 0.072778 | 1.138 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 0.097484 | 1.011 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.198300 | 0.703 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.081899 | 1.087 |
| R-HSA-6783783 | Interleukin-10 signaling | 0.147986 | 0.830 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.206869 | 0.684 |
| R-HSA-69206 | G1/S Transition | 0.099626 | 1.002 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.139882 | 0.854 |
| R-HSA-917937 | Iron uptake and transport | 0.139882 | 0.854 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.174324 | 0.759 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.081321 | 1.090 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.142355 | 0.847 |
| R-HSA-379724 | tRNA Aminoacylation | 0.101096 | 0.995 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.167806 | 0.775 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.140541 | 0.852 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.090828 | 1.042 |
| R-HSA-9679506 | SARS-CoV Infections | 0.170979 | 0.767 |
| R-HSA-168255 | Influenza Infection | 0.206060 | 0.686 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.151543 | 0.819 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.113663 | 0.944 |
| R-HSA-1266738 | Developmental Biology | 0.206249 | 0.686 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.129238 | 0.889 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.129163 | 0.889 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.172825 | 0.762 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.126323 | 0.899 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.189740 | 0.722 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.142572 | 0.846 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.175626 | 0.755 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.208263 | 0.681 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.209741 | 0.678 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.210869 | 0.676 |
| R-HSA-428930 | Thromboxane signalling through TP receptor | 0.210869 | 0.676 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.210869 | 0.676 |
| R-HSA-429947 | Deadenylation of mRNA | 0.210869 | 0.676 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.210869 | 0.676 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.212617 | 0.672 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.212617 | 0.672 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.212617 | 0.672 |
| R-HSA-162582 | Signal Transduction | 0.214360 | 0.669 |
| R-HSA-9658195 | Leishmania infection | 0.214602 | 0.668 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.214602 | 0.668 |
| R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | 0.217080 | 0.663 |
| R-HSA-1296059 | G protein gated Potassium channels | 0.217080 | 0.663 |
| R-HSA-1296041 | Activation of G protein gated Potassium channels | 0.217080 | 0.663 |
| R-HSA-3000157 | Laminin interactions | 0.217080 | 0.663 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.217080 | 0.663 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.218380 | 0.661 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.221267 | 0.655 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.223242 | 0.651 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.223242 | 0.651 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.223242 | 0.651 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.223242 | 0.651 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.223242 | 0.651 |
| R-HSA-3295583 | TRP channels | 0.223242 | 0.651 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.224157 | 0.649 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.224462 | 0.649 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.229356 | 0.639 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.229356 | 0.639 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 0.229356 | 0.639 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.230668 | 0.637 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.235423 | 0.628 |
| R-HSA-451326 | Activation of kainate receptors upon glutamate binding | 0.235423 | 0.628 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 0.235423 | 0.628 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.235746 | 0.628 |
| R-HSA-1643685 | Disease | 0.239476 | 0.621 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.241442 | 0.617 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.241442 | 0.617 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.241442 | 0.617 |
| R-HSA-420092 | Glucagon-type ligand receptors | 0.241442 | 0.617 |
| R-HSA-69239 | Synthesis of DNA | 0.241553 | 0.617 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.244460 | 0.612 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.244460 | 0.612 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.244460 | 0.612 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.247368 | 0.607 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.247414 | 0.607 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.247414 | 0.607 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.247414 | 0.607 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.249470 | 0.603 |
| R-HSA-399719 | Trafficking of AMPA receptors | 0.253340 | 0.596 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.253340 | 0.596 |
| R-HSA-2129379 | Molecules associated with elastic fibres | 0.253340 | 0.596 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.253340 | 0.596 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.253681 | 0.596 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.259010 | 0.587 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 0.259219 | 0.586 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.259219 | 0.586 |
| R-HSA-69190 | DNA strand elongation | 0.259219 | 0.586 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.265052 | 0.577 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.265052 | 0.577 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.265052 | 0.577 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.265052 | 0.577 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.265052 | 0.577 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.265052 | 0.577 |
| R-HSA-382551 | Transport of small molecules | 0.266926 | 0.574 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.267748 | 0.572 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.270840 | 0.567 |
| R-HSA-390522 | Striated Muscle Contraction | 0.270840 | 0.567 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.270840 | 0.567 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.270840 | 0.567 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.276582 | 0.558 |
| R-HSA-392518 | Signal amplification | 0.276582 | 0.558 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.276582 | 0.558 |
| R-HSA-5205647 | Mitophagy | 0.276582 | 0.558 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.276582 | 0.558 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.276582 | 0.558 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.276582 | 0.558 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.276582 | 0.558 |
| R-HSA-5365859 | RA biosynthesis pathway | 0.276582 | 0.558 |
| R-HSA-397014 | Muscle contraction | 0.277012 | 0.558 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.282280 | 0.549 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.282280 | 0.549 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.282280 | 0.549 |
| R-HSA-169911 | Regulation of Apoptosis | 0.282280 | 0.549 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.282280 | 0.549 |
| R-HSA-381042 | PERK regulates gene expression | 0.282280 | 0.549 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.282309 | 0.549 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.282309 | 0.549 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.287933 | 0.541 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.287933 | 0.541 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.287933 | 0.541 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.287933 | 0.541 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.291036 | 0.536 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.291036 | 0.536 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.293542 | 0.532 |
| R-HSA-4641258 | Degradation of DVL | 0.293542 | 0.532 |
| R-HSA-4641257 | Degradation of AXIN | 0.293542 | 0.532 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.293542 | 0.532 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.293542 | 0.532 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.293542 | 0.532 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.299107 | 0.524 |
| R-HSA-1566948 | Elastic fibre formation | 0.299107 | 0.524 |
| R-HSA-8875878 | MET promotes cell motility | 0.299107 | 0.524 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.299107 | 0.524 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.304628 | 0.516 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.304628 | 0.516 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.304628 | 0.516 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.304628 | 0.516 |
| R-HSA-69541 | Stabilization of p53 | 0.304628 | 0.516 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.310107 | 0.508 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.310107 | 0.508 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 0.310107 | 0.508 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.311343 | 0.507 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.315542 | 0.501 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.315542 | 0.501 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.315542 | 0.501 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.315542 | 0.501 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.318161 | 0.497 |
| R-HSA-72312 | rRNA processing | 0.319896 | 0.495 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.320935 | 0.494 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 0.320935 | 0.494 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.320935 | 0.494 |
| R-HSA-5576891 | Cardiac conduction | 0.322897 | 0.491 |
| R-HSA-6798695 | Neutrophil degranulation | 0.325609 | 0.487 |
| R-HSA-9909396 | Circadian clock | 0.325779 | 0.487 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.326286 | 0.486 |
| R-HSA-991365 | Activation of GABAB receptors | 0.326286 | 0.486 |
| R-HSA-977444 | GABA B receptor activation | 0.326286 | 0.486 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.326286 | 0.486 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.328657 | 0.483 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.328847 | 0.483 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.331595 | 0.479 |
| R-HSA-8854214 | TBC/RABGAPs | 0.331595 | 0.479 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.331595 | 0.479 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.336863 | 0.473 |
| R-HSA-2172127 | DAP12 interactions | 0.336863 | 0.473 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.342089 | 0.466 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.342089 | 0.466 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.342089 | 0.466 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.342089 | 0.466 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.342089 | 0.466 |
| R-HSA-9824272 | Somitogenesis | 0.342089 | 0.466 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.347275 | 0.459 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.347275 | 0.459 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.347275 | 0.459 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.347275 | 0.459 |
| R-HSA-73894 | DNA Repair | 0.352068 | 0.453 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.352420 | 0.453 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 0.352420 | 0.453 |
| R-HSA-70263 | Gluconeogenesis | 0.357524 | 0.447 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.357524 | 0.447 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.360078 | 0.444 |
| R-HSA-73893 | DNA Damage Bypass | 0.362589 | 0.441 |
| R-HSA-9766229 | Degradation of CDH1 | 0.362589 | 0.441 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 0.362589 | 0.441 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.362589 | 0.441 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.362589 | 0.441 |
| R-HSA-8953854 | Metabolism of RNA | 0.363185 | 0.440 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.365737 | 0.437 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.367614 | 0.435 |
| R-HSA-912446 | Meiotic recombination | 0.372600 | 0.429 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.372600 | 0.429 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.372600 | 0.429 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.372600 | 0.429 |
| R-HSA-2514856 | The phototransduction cascade | 0.372600 | 0.429 |
| R-HSA-69242 | S Phase | 0.376997 | 0.424 |
| R-HSA-166520 | Signaling by NTRKs | 0.376997 | 0.424 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.377547 | 0.423 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.377547 | 0.423 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.377547 | 0.423 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.377547 | 0.423 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.377547 | 0.423 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.377547 | 0.423 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.382455 | 0.417 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.382455 | 0.417 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.382455 | 0.417 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.382455 | 0.417 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.382455 | 0.417 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.382455 | 0.417 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.386385 | 0.413 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.387325 | 0.412 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.391109 | 0.408 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.392157 | 0.407 |
| R-HSA-913531 | Interferon Signaling | 0.394935 | 0.403 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.396951 | 0.401 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.396951 | 0.401 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.396951 | 0.401 |
| R-HSA-75893 | TNF signaling | 0.396951 | 0.401 |
| R-HSA-177929 | Signaling by EGFR | 0.396951 | 0.401 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.401707 | 0.396 |
| R-HSA-5621480 | Dectin-2 family | 0.401707 | 0.396 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.401707 | 0.396 |
| R-HSA-162587 | HIV Life Cycle | 0.402025 | 0.396 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.406426 | 0.391 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.410265 | 0.387 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.410265 | 0.387 |
| R-HSA-180786 | Extension of Telomeres | 0.411108 | 0.386 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.411108 | 0.386 |
| R-HSA-977443 | GABA receptor activation | 0.415754 | 0.381 |
| R-HSA-351202 | Metabolism of polyamines | 0.415754 | 0.381 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.415754 | 0.381 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.415754 | 0.381 |
| R-HSA-446728 | Cell junction organization | 0.418098 | 0.379 |
| R-HSA-450294 | MAP kinase activation | 0.420363 | 0.376 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.420363 | 0.376 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.420363 | 0.376 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.424936 | 0.372 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.426471 | 0.370 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.429474 | 0.367 |
| R-HSA-373755 | Semaphorin interactions | 0.429474 | 0.367 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.438442 | 0.358 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.445311 | 0.351 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.447270 | 0.349 |
| R-HSA-9830369 | Kidney development | 0.447270 | 0.349 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.447960 | 0.349 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.447960 | 0.349 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.447960 | 0.349 |
| R-HSA-913709 | O-linked glycosylation of mucins | 0.451633 | 0.345 |
| R-HSA-448424 | Interleukin-17 signaling | 0.460256 | 0.337 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.460256 | 0.337 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.460256 | 0.337 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.460256 | 0.337 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.460256 | 0.337 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.464516 | 0.333 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 0.464516 | 0.333 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.464516 | 0.333 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.464516 | 0.333 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.464516 | 0.333 |
| R-HSA-3000178 | ECM proteoglycans | 0.464516 | 0.333 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.464516 | 0.333 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.468744 | 0.329 |
| R-HSA-74259 | Purine catabolism | 0.468744 | 0.329 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.472938 | 0.325 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.474056 | 0.324 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.477099 | 0.321 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.481228 | 0.318 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.481228 | 0.318 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.485325 | 0.314 |
| R-HSA-5689603 | UCH proteinases | 0.485325 | 0.314 |
| R-HSA-983712 | Ion channel transport | 0.489357 | 0.310 |
| R-HSA-216083 | Integrin cell surface interactions | 0.493422 | 0.307 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.493422 | 0.307 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.493422 | 0.307 |
| R-HSA-5619084 | ABC transporter disorders | 0.493422 | 0.307 |
| R-HSA-1500931 | Cell-Cell communication | 0.495734 | 0.305 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.496903 | 0.304 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.497423 | 0.303 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.501392 | 0.300 |
| R-HSA-6806834 | Signaling by MET | 0.501392 | 0.300 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.505331 | 0.296 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.505331 | 0.296 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.506856 | 0.295 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.509238 | 0.293 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.513115 | 0.290 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.516681 | 0.287 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.516962 | 0.287 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.519414 | 0.284 |
| R-HSA-1500620 | Meiosis | 0.520778 | 0.283 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.523966 | 0.281 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.528322 | 0.277 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.539416 | 0.268 |
| R-HSA-73884 | Base Excision Repair | 0.543057 | 0.265 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.543057 | 0.265 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.546669 | 0.262 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.550045 | 0.260 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.557335 | 0.254 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.560835 | 0.251 |
| R-HSA-418990 | Adherens junctions interactions | 0.561567 | 0.251 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.564307 | 0.248 |
| R-HSA-8951664 | Neddylation | 0.568380 | 0.245 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.571171 | 0.243 |
| R-HSA-1296071 | Potassium Channels | 0.571171 | 0.243 |
| R-HSA-157579 | Telomere Maintenance | 0.574562 | 0.241 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.574562 | 0.241 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.577927 | 0.238 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.577927 | 0.238 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.584148 | 0.233 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.584577 | 0.233 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.586176 | 0.232 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.587863 | 0.231 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.594358 | 0.226 |
| R-HSA-8939211 | ESR-mediated signaling | 0.603429 | 0.219 |
| R-HSA-418346 | Platelet homeostasis | 0.607045 | 0.217 |
| R-HSA-157118 | Signaling by NOTCH | 0.609759 | 0.215 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.613240 | 0.212 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.616301 | 0.210 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.619338 | 0.208 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.620380 | 0.207 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.631250 | 0.200 |
| R-HSA-421270 | Cell-cell junction organization | 0.632317 | 0.199 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.634170 | 0.198 |
| R-HSA-5688426 | Deubiquitination | 0.640267 | 0.194 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.642233 | 0.192 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.645620 | 0.190 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.645620 | 0.190 |
| R-HSA-5693538 | Homology Directed Repair | 0.648427 | 0.188 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.651212 | 0.186 |
| R-HSA-68875 | Mitotic Prophase | 0.653975 | 0.184 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.656716 | 0.183 |
| R-HSA-114608 | Platelet degranulation | 0.675309 | 0.170 |
| R-HSA-8956319 | Nucleotide catabolism | 0.680436 | 0.167 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.681871 | 0.166 |
| R-HSA-1474165 | Reproduction | 0.685482 | 0.164 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.702529 | 0.153 |
| R-HSA-5173105 | O-linked glycosylation | 0.704888 | 0.152 |
| R-HSA-5368287 | Mitochondrial translation | 0.707229 | 0.150 |
| R-HSA-6807070 | PTEN Regulation | 0.709551 | 0.149 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.711226 | 0.148 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.718659 | 0.143 |
| R-HSA-2187338 | Visual phototransduction | 0.729646 | 0.137 |
| R-HSA-9758941 | Gastrulation | 0.733921 | 0.134 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.736033 | 0.133 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.738128 | 0.132 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.740207 | 0.131 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.742270 | 0.129 |
| R-HSA-73887 | Death Receptor Signaling | 0.744316 | 0.128 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.752342 | 0.124 |
| R-HSA-1474244 | Extracellular matrix organization | 0.766836 | 0.115 |
| R-HSA-611105 | Respiratory electron transport | 0.790549 | 0.102 |
| R-HSA-2559583 | Cellular Senescence | 0.793868 | 0.100 |
| R-HSA-3781865 | Diseases of glycosylation | 0.800349 | 0.097 |
| R-HSA-74160 | Gene expression (Transcription) | 0.803195 | 0.095 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.803513 | 0.095 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.815680 | 0.088 |
| R-HSA-72172 | mRNA Splicing | 0.831198 | 0.080 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.858451 | 0.066 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.862914 | 0.064 |
| R-HSA-15869 | Metabolism of nucleotides | 0.869349 | 0.061 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.870392 | 0.060 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.880377 | 0.055 |
| R-HSA-212436 | Generic Transcription Pathway | 0.882440 | 0.054 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.898929 | 0.046 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.907477 | 0.042 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.914624 | 0.039 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.918646 | 0.037 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.919297 | 0.037 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.927043 | 0.033 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.935065 | 0.029 |
| R-HSA-8957322 | Metabolism of steroids | 0.935587 | 0.029 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.953355 | 0.021 |
| R-HSA-500792 | GPCR ligand binding | 0.955514 | 0.020 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.963699 | 0.016 |
| R-HSA-8978868 | Fatty acid metabolism | 0.967326 | 0.014 |
| R-HSA-5668914 | Diseases of metabolism | 0.972217 | 0.012 |
| R-HSA-1430728 | Metabolism | 0.976547 | 0.010 |
| R-HSA-556833 | Metabolism of lipids | 0.993829 | 0.003 |
| R-HSA-9709957 | Sensory Perception | 0.999967 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
FAM20C |
0.833 | 0.434 | 2 | 0.840 |
BMPR1B |
0.822 | 0.382 | 1 | 0.835 |
COT |
0.822 | 0.196 | 2 | 0.795 |
CLK3 |
0.818 | 0.197 | 1 | 0.809 |
GRK1 |
0.818 | 0.256 | -2 | 0.749 |
ALK2 |
0.815 | 0.439 | -2 | 0.884 |
BMPR1A |
0.815 | 0.403 | 1 | 0.839 |
MOS |
0.815 | 0.216 | 1 | 0.907 |
CAMK2G |
0.814 | 0.185 | 2 | 0.808 |
TGFBR1 |
0.813 | 0.349 | -2 | 0.884 |
CDC7 |
0.812 | 0.159 | 1 | 0.912 |
GRK6 |
0.811 | 0.234 | 1 | 0.824 |
CAMK2B |
0.811 | 0.240 | 2 | 0.832 |
CK2A2 |
0.810 | 0.354 | 1 | 0.796 |
DSTYK |
0.810 | 0.184 | 2 | 0.819 |
IKKA |
0.810 | 0.209 | -2 | 0.694 |
GRK7 |
0.808 | 0.240 | 1 | 0.740 |
PIM3 |
0.805 | 0.066 | -3 | 0.786 |
PRPK |
0.804 | 0.016 | -1 | 0.837 |
IKKB |
0.804 | 0.078 | -2 | 0.699 |
ALK4 |
0.801 | 0.257 | -2 | 0.898 |
ACVR2B |
0.801 | 0.281 | -2 | 0.861 |
BMPR2 |
0.801 | 0.105 | -2 | 0.860 |
RAF1 |
0.799 | -0.020 | 1 | 0.811 |
ATM |
0.799 | 0.130 | 1 | 0.752 |
GRK4 |
0.799 | 0.118 | -2 | 0.814 |
ACVR2A |
0.799 | 0.255 | -2 | 0.853 |
PLK3 |
0.798 | 0.180 | 2 | 0.749 |
CK2A1 |
0.797 | 0.296 | 1 | 0.771 |
NEK6 |
0.797 | 0.040 | -2 | 0.853 |
NDR2 |
0.797 | 0.014 | -3 | 0.788 |
CAMK2A |
0.797 | 0.135 | 2 | 0.803 |
GRK5 |
0.796 | 0.036 | -3 | 0.788 |
CAMK1B |
0.796 | -0.019 | -3 | 0.799 |
SKMLCK |
0.795 | 0.039 | -2 | 0.806 |
ATR |
0.795 | 0.004 | 1 | 0.794 |
GCN2 |
0.795 | -0.066 | 2 | 0.722 |
PIM1 |
0.795 | 0.065 | -3 | 0.741 |
PLK1 |
0.795 | 0.120 | -2 | 0.816 |
PDHK4 |
0.794 | -0.129 | 1 | 0.808 |
TBK1 |
0.792 | -0.055 | 1 | 0.688 |
LATS1 |
0.792 | 0.132 | -3 | 0.798 |
NEK7 |
0.792 | -0.021 | -3 | 0.788 |
PRKD1 |
0.791 | 0.024 | -3 | 0.751 |
MTOR |
0.790 | -0.111 | 1 | 0.733 |
IKKE |
0.790 | -0.051 | 1 | 0.689 |
CAMK2D |
0.789 | 0.036 | -3 | 0.770 |
MAPKAPK2 |
0.789 | 0.075 | -3 | 0.684 |
RSK2 |
0.789 | 0.023 | -3 | 0.717 |
TGFBR2 |
0.789 | 0.049 | -2 | 0.866 |
PLK2 |
0.788 | 0.212 | -3 | 0.798 |
ULK2 |
0.788 | -0.144 | 2 | 0.700 |
PKN3 |
0.788 | -0.024 | -3 | 0.764 |
LATS2 |
0.786 | 0.014 | -5 | 0.636 |
TLK2 |
0.786 | 0.096 | 1 | 0.744 |
CAMLCK |
0.786 | -0.049 | -2 | 0.798 |
CDKL1 |
0.786 | -0.039 | -3 | 0.740 |
HUNK |
0.785 | -0.085 | 2 | 0.716 |
PDHK1 |
0.785 | -0.183 | 1 | 0.797 |
DLK |
0.784 | -0.080 | 1 | 0.781 |
DAPK2 |
0.784 | -0.071 | -3 | 0.800 |
NIK |
0.784 | -0.150 | -3 | 0.817 |
MARK4 |
0.784 | -0.061 | 4 | 0.657 |
MLK1 |
0.783 | -0.101 | 2 | 0.722 |
ERK5 |
0.783 | -0.068 | 1 | 0.727 |
KIS |
0.783 | 0.026 | 1 | 0.638 |
CLK2 |
0.782 | 0.106 | -3 | 0.712 |
ULK1 |
0.782 | -0.119 | -3 | 0.753 |
PRKD2 |
0.782 | 0.005 | -3 | 0.718 |
RSK4 |
0.781 | 0.047 | -3 | 0.701 |
SRPK1 |
0.781 | 0.003 | -3 | 0.697 |
CHAK2 |
0.781 | -0.070 | -1 | 0.811 |
NLK |
0.781 | -0.134 | 1 | 0.765 |
BRAF |
0.781 | 0.079 | -4 | 0.768 |
P70S6KB |
0.781 | -0.028 | -3 | 0.738 |
DNAPK |
0.780 | 0.082 | 1 | 0.677 |
GRK2 |
0.779 | 0.036 | -2 | 0.725 |
PASK |
0.779 | 0.093 | -3 | 0.801 |
BCKDK |
0.779 | -0.119 | -1 | 0.759 |
TSSK2 |
0.779 | -0.032 | -5 | 0.709 |
P90RSK |
0.779 | -0.034 | -3 | 0.722 |
PKR |
0.778 | -0.046 | 1 | 0.790 |
NDR1 |
0.778 | -0.093 | -3 | 0.779 |
ANKRD3 |
0.777 | -0.163 | 1 | 0.794 |
PKCD |
0.777 | -0.059 | 2 | 0.704 |
PRKX |
0.776 | 0.078 | -3 | 0.654 |
MSK1 |
0.776 | 0.024 | -3 | 0.689 |
AURA |
0.776 | 0.027 | -2 | 0.601 |
MSK2 |
0.776 | -0.014 | -3 | 0.684 |
ICK |
0.776 | -0.059 | -3 | 0.774 |
MLK3 |
0.775 | -0.057 | 2 | 0.657 |
SRPK2 |
0.775 | 0.009 | -3 | 0.623 |
JNK3 |
0.775 | 0.027 | 1 | 0.598 |
RIPK3 |
0.775 | -0.198 | 3 | 0.654 |
MLK4 |
0.774 | -0.029 | 2 | 0.650 |
MEK1 |
0.774 | -0.111 | 2 | 0.752 |
CDK1 |
0.774 | 0.021 | 1 | 0.575 |
WNK1 |
0.774 | -0.163 | -2 | 0.794 |
NUAK2 |
0.773 | -0.118 | -3 | 0.793 |
RSK3 |
0.773 | -0.051 | -3 | 0.708 |
MST4 |
0.773 | -0.120 | 2 | 0.752 |
NEK9 |
0.773 | -0.200 | 2 | 0.723 |
HIPK4 |
0.773 | -0.067 | 1 | 0.728 |
PKACB |
0.773 | 0.026 | -2 | 0.650 |
MAPKAPK3 |
0.772 | -0.064 | -3 | 0.717 |
AMPKA1 |
0.772 | -0.121 | -3 | 0.796 |
CDKL5 |
0.772 | -0.071 | -3 | 0.730 |
PAK1 |
0.772 | -0.048 | -2 | 0.719 |
PKACG |
0.772 | -0.052 | -2 | 0.709 |
JNK2 |
0.772 | 0.025 | 1 | 0.560 |
TTBK2 |
0.771 | -0.140 | 2 | 0.602 |
GRK3 |
0.771 | 0.055 | -2 | 0.697 |
YSK4 |
0.771 | -0.115 | 1 | 0.729 |
MASTL |
0.771 | -0.296 | -2 | 0.761 |
TLK1 |
0.771 | 0.004 | -2 | 0.865 |
CLK4 |
0.771 | 0.008 | -3 | 0.719 |
TSSK1 |
0.770 | -0.074 | -3 | 0.813 |
CHK1 |
0.770 | -0.009 | -3 | 0.778 |
GSK3A |
0.770 | 0.013 | 4 | 0.311 |
PKN2 |
0.770 | -0.140 | -3 | 0.775 |
SRPK3 |
0.769 | -0.024 | -3 | 0.666 |
PRP4 |
0.769 | 0.032 | -3 | 0.741 |
MARK2 |
0.769 | -0.048 | 4 | 0.575 |
CDK8 |
0.769 | -0.031 | 1 | 0.605 |
WNK3 |
0.769 | -0.288 | 1 | 0.762 |
AURC |
0.768 | -0.023 | -2 | 0.628 |
DYRK2 |
0.768 | -0.019 | 1 | 0.626 |
CAMK4 |
0.767 | -0.121 | -3 | 0.764 |
MLK2 |
0.767 | -0.228 | 2 | 0.720 |
VRK2 |
0.767 | -0.315 | 1 | 0.810 |
DRAK1 |
0.766 | -0.074 | 1 | 0.727 |
MARK3 |
0.765 | -0.059 | 4 | 0.600 |
PDHK3_TYR |
0.765 | 0.265 | 4 | 0.736 |
QSK |
0.765 | -0.081 | 4 | 0.628 |
BRSK1 |
0.764 | -0.074 | -3 | 0.732 |
SMG1 |
0.764 | -0.075 | 1 | 0.742 |
MYLK4 |
0.764 | -0.059 | -2 | 0.725 |
RIPK1 |
0.763 | -0.273 | 1 | 0.748 |
P38B |
0.763 | -0.003 | 1 | 0.565 |
PERK |
0.763 | -0.094 | -2 | 0.844 |
CK1E |
0.763 | -0.015 | -3 | 0.561 |
AMPKA2 |
0.762 | -0.125 | -3 | 0.767 |
MEKK3 |
0.762 | -0.134 | 1 | 0.737 |
NIM1 |
0.762 | -0.177 | 3 | 0.707 |
P38A |
0.762 | -0.038 | 1 | 0.630 |
PRKD3 |
0.761 | -0.065 | -3 | 0.680 |
CLK1 |
0.761 | -0.012 | -3 | 0.694 |
AURB |
0.761 | -0.046 | -2 | 0.626 |
P38G |
0.760 | -0.005 | 1 | 0.487 |
GAK |
0.760 | 0.000 | 1 | 0.782 |
CDK5 |
0.760 | -0.040 | 1 | 0.635 |
GSK3B |
0.760 | -0.052 | 4 | 0.290 |
PDHK4_TYR |
0.760 | 0.179 | 2 | 0.821 |
PAK3 |
0.760 | -0.133 | -2 | 0.713 |
MARK1 |
0.759 | -0.083 | 4 | 0.616 |
CDK2 |
0.759 | -0.048 | 1 | 0.647 |
DYRK4 |
0.759 | 0.012 | 1 | 0.563 |
PDHK1_TYR |
0.759 | 0.203 | -1 | 0.886 |
PKCB |
0.759 | -0.111 | 2 | 0.643 |
MEKK2 |
0.759 | -0.133 | 2 | 0.713 |
NEK5 |
0.759 | -0.146 | 1 | 0.761 |
MAP2K6_TYR |
0.759 | 0.192 | -1 | 0.852 |
PINK1 |
0.759 | -0.118 | 1 | 0.766 |
MNK2 |
0.759 | -0.100 | -2 | 0.732 |
IRE2 |
0.758 | -0.156 | 2 | 0.662 |
SIK |
0.758 | -0.089 | -3 | 0.701 |
TAO3 |
0.758 | -0.074 | 1 | 0.742 |
NEK2 |
0.758 | -0.192 | 2 | 0.684 |
PAK2 |
0.758 | -0.113 | -2 | 0.704 |
HRI |
0.758 | -0.167 | -2 | 0.850 |
PKCA |
0.758 | -0.119 | 2 | 0.640 |
PIM2 |
0.758 | -0.043 | -3 | 0.690 |
CDK19 |
0.758 | -0.045 | 1 | 0.564 |
NUAK1 |
0.758 | -0.119 | -3 | 0.739 |
CDK3 |
0.758 | 0.012 | 1 | 0.516 |
ZAK |
0.757 | -0.168 | 1 | 0.732 |
PLK4 |
0.757 | -0.135 | 2 | 0.579 |
IRE1 |
0.757 | -0.232 | 1 | 0.732 |
JNK1 |
0.757 | 0.013 | 1 | 0.554 |
DCAMKL1 |
0.757 | -0.073 | -3 | 0.738 |
DAPK3 |
0.757 | -0.011 | -3 | 0.750 |
CK1D |
0.756 | -0.008 | -3 | 0.510 |
MEKK1 |
0.756 | -0.186 | 1 | 0.750 |
ERK1 |
0.756 | -0.033 | 1 | 0.554 |
PKCG |
0.755 | -0.141 | 2 | 0.642 |
PKACA |
0.755 | 0.003 | -2 | 0.606 |
CAMKK1 |
0.755 | -0.105 | -2 | 0.684 |
SGK3 |
0.755 | -0.067 | -3 | 0.702 |
AKT2 |
0.755 | -0.043 | -3 | 0.642 |
CDK13 |
0.755 | -0.064 | 1 | 0.592 |
MNK1 |
0.755 | -0.099 | -2 | 0.744 |
CAMK1D |
0.755 | -0.020 | -3 | 0.643 |
P38D |
0.754 | 0.009 | 1 | 0.516 |
HIPK2 |
0.754 | -0.014 | 1 | 0.545 |
PKCH |
0.754 | -0.144 | 2 | 0.635 |
ALPHAK3 |
0.754 | 0.167 | -1 | 0.798 |
MELK |
0.754 | -0.163 | -3 | 0.744 |
NEK8 |
0.754 | -0.154 | 2 | 0.712 |
QIK |
0.754 | -0.221 | -3 | 0.766 |
MAP2K4_TYR |
0.753 | 0.076 | -1 | 0.849 |
MEK5 |
0.753 | -0.331 | 2 | 0.734 |
TAK1 |
0.753 | -0.049 | 1 | 0.788 |
PKG2 |
0.753 | -0.067 | -2 | 0.650 |
CDK18 |
0.753 | -0.049 | 1 | 0.544 |
ERK2 |
0.753 | -0.067 | 1 | 0.597 |
CHAK1 |
0.752 | -0.229 | 2 | 0.623 |
MAPKAPK5 |
0.752 | -0.117 | -3 | 0.652 |
CAMK1G |
0.752 | -0.106 | -3 | 0.702 |
DYRK1A |
0.752 | -0.051 | 1 | 0.677 |
SMMLCK |
0.751 | -0.105 | -3 | 0.750 |
DCAMKL2 |
0.751 | -0.086 | -3 | 0.759 |
MST2 |
0.751 | -0.070 | 1 | 0.752 |
PKCZ |
0.751 | -0.170 | 2 | 0.667 |
BMPR2_TYR |
0.751 | 0.051 | -1 | 0.835 |
HIPK1 |
0.750 | -0.053 | 1 | 0.641 |
DAPK1 |
0.750 | -0.020 | -3 | 0.733 |
EPHA4 |
0.750 | 0.149 | 2 | 0.756 |
BRSK2 |
0.750 | -0.172 | -3 | 0.752 |
CDK7 |
0.750 | -0.101 | 1 | 0.623 |
EPHA6 |
0.750 | 0.079 | -1 | 0.870 |
CAMKK2 |
0.749 | -0.139 | -2 | 0.680 |
EEF2K |
0.749 | -0.074 | 3 | 0.738 |
CDK17 |
0.749 | -0.050 | 1 | 0.495 |
CK1A2 |
0.748 | -0.036 | -3 | 0.511 |
FER |
0.748 | 0.141 | 1 | 0.848 |
PAK6 |
0.748 | -0.085 | -2 | 0.639 |
GCK |
0.748 | -0.103 | 1 | 0.741 |
LKB1 |
0.747 | -0.161 | -3 | 0.780 |
TESK1_TYR |
0.747 | -0.115 | 3 | 0.810 |
MST3 |
0.747 | -0.184 | 2 | 0.710 |
PHKG1 |
0.747 | -0.191 | -3 | 0.771 |
SSTK |
0.747 | -0.116 | 4 | 0.608 |
MAP2K7_TYR |
0.746 | -0.131 | 2 | 0.788 |
TXK |
0.746 | 0.144 | 1 | 0.827 |
DYRK1B |
0.745 | -0.046 | 1 | 0.583 |
CDK12 |
0.745 | -0.073 | 1 | 0.563 |
EPHB4 |
0.745 | 0.059 | -1 | 0.852 |
CK1G1 |
0.745 | -0.071 | -3 | 0.545 |
SNRK |
0.744 | -0.258 | 2 | 0.625 |
WNK4 |
0.744 | -0.251 | -2 | 0.790 |
TAO2 |
0.744 | -0.195 | 2 | 0.748 |
SRMS |
0.743 | 0.129 | 1 | 0.834 |
P70S6K |
0.743 | -0.087 | -3 | 0.643 |
CDK16 |
0.743 | -0.040 | 1 | 0.512 |
PINK1_TYR |
0.742 | -0.114 | 1 | 0.793 |
NEK11 |
0.742 | -0.284 | 1 | 0.738 |
TNIK |
0.742 | -0.118 | 3 | 0.752 |
AKT1 |
0.742 | -0.058 | -3 | 0.661 |
PDK1 |
0.741 | -0.174 | 1 | 0.747 |
TTK |
0.741 | 0.013 | -2 | 0.842 |
DYRK3 |
0.741 | -0.054 | 1 | 0.642 |
EPHB2 |
0.741 | 0.119 | -1 | 0.848 |
INSRR |
0.740 | 0.060 | 3 | 0.646 |
TTBK1 |
0.740 | -0.180 | 2 | 0.539 |
VRK1 |
0.739 | -0.216 | 2 | 0.725 |
SGK1 |
0.739 | -0.018 | -3 | 0.568 |
OSR1 |
0.739 | -0.039 | 2 | 0.701 |
CDK9 |
0.739 | -0.108 | 1 | 0.595 |
ABL2 |
0.739 | 0.043 | -1 | 0.849 |
YES1 |
0.739 | 0.042 | -1 | 0.841 |
RET |
0.737 | -0.108 | 1 | 0.743 |
MST1 |
0.737 | -0.147 | 1 | 0.731 |
PKMYT1_TYR |
0.737 | -0.225 | 3 | 0.771 |
MPSK1 |
0.737 | -0.168 | 1 | 0.714 |
EPHA5 |
0.737 | 0.142 | 2 | 0.767 |
EPHB3 |
0.737 | 0.068 | -1 | 0.842 |
ERK7 |
0.737 | -0.075 | 2 | 0.450 |
FGFR2 |
0.737 | -0.008 | 3 | 0.717 |
IRAK4 |
0.736 | -0.289 | 1 | 0.737 |
PKCT |
0.736 | -0.167 | 2 | 0.644 |
CDK14 |
0.736 | -0.095 | 1 | 0.582 |
MINK |
0.736 | -0.190 | 1 | 0.734 |
HIPK3 |
0.736 | -0.109 | 1 | 0.632 |
EPHB1 |
0.736 | 0.036 | 1 | 0.820 |
NEK4 |
0.735 | -0.266 | 1 | 0.727 |
FGR |
0.735 | -0.034 | 1 | 0.775 |
YANK3 |
0.735 | -0.036 | 2 | 0.391 |
BLK |
0.734 | 0.096 | -1 | 0.838 |
FYN |
0.734 | 0.110 | -1 | 0.788 |
ROCK2 |
0.734 | -0.064 | -3 | 0.736 |
HGK |
0.734 | -0.203 | 3 | 0.743 |
LRRK2 |
0.734 | -0.283 | 2 | 0.739 |
NEK1 |
0.733 | -0.238 | 1 | 0.736 |
SYK |
0.733 | 0.146 | -1 | 0.789 |
CSF1R |
0.733 | -0.074 | 3 | 0.667 |
MRCKA |
0.733 | -0.074 | -3 | 0.701 |
EPHA7 |
0.732 | 0.050 | 2 | 0.749 |
MAP3K15 |
0.732 | -0.272 | 1 | 0.713 |
ABL1 |
0.732 | -0.016 | -1 | 0.843 |
MAK |
0.732 | -0.019 | -2 | 0.660 |
KIT |
0.732 | -0.033 | 3 | 0.678 |
HPK1 |
0.731 | -0.185 | 1 | 0.726 |
HCK |
0.731 | -0.003 | -1 | 0.814 |
SLK |
0.731 | -0.140 | -2 | 0.653 |
PHKG2 |
0.731 | -0.192 | -3 | 0.737 |
DDR1 |
0.731 | -0.150 | 4 | 0.653 |
EGFR |
0.731 | 0.063 | 1 | 0.624 |
TYRO3 |
0.731 | -0.149 | 3 | 0.672 |
STK33 |
0.731 | -0.182 | 2 | 0.560 |
MRCKB |
0.731 | -0.072 | -3 | 0.681 |
MEK2 |
0.731 | -0.251 | 2 | 0.709 |
SBK |
0.731 | -0.024 | -3 | 0.530 |
LIMK2_TYR |
0.730 | -0.214 | -3 | 0.819 |
TYK2 |
0.730 | -0.192 | 1 | 0.745 |
CAMK1A |
0.730 | -0.072 | -3 | 0.603 |
FGFR3 |
0.730 | 0.000 | 3 | 0.690 |
PKCE |
0.730 | -0.124 | 2 | 0.623 |
LCK |
0.730 | 0.027 | -1 | 0.819 |
JAK3 |
0.729 | -0.093 | 1 | 0.734 |
EPHA3 |
0.729 | -0.015 | 2 | 0.732 |
MST1R |
0.729 | -0.210 | 3 | 0.694 |
ROS1 |
0.729 | -0.156 | 3 | 0.637 |
IRAK1 |
0.729 | -0.328 | -1 | 0.705 |
MERTK |
0.729 | -0.002 | 3 | 0.676 |
KHS1 |
0.729 | -0.156 | 1 | 0.722 |
AKT3 |
0.728 | -0.052 | -3 | 0.585 |
JAK2 |
0.728 | -0.159 | 1 | 0.742 |
KHS2 |
0.728 | -0.124 | 1 | 0.733 |
FLT3 |
0.727 | -0.079 | 3 | 0.663 |
TEC |
0.727 | 0.011 | -1 | 0.751 |
MEKK6 |
0.727 | -0.330 | 1 | 0.731 |
CHK2 |
0.727 | -0.087 | -3 | 0.588 |
PAK5 |
0.727 | -0.116 | -2 | 0.583 |
NTRK1 |
0.727 | -0.030 | -1 | 0.828 |
EPHA8 |
0.726 | 0.059 | -1 | 0.829 |
LOK |
0.726 | -0.219 | -2 | 0.698 |
FGFR4 |
0.726 | 0.060 | -1 | 0.823 |
DMPK1 |
0.726 | -0.051 | -3 | 0.709 |
ITK |
0.726 | -0.040 | -1 | 0.780 |
PKCI |
0.726 | -0.192 | 2 | 0.636 |
FLT1 |
0.726 | -0.026 | -1 | 0.849 |
BUB1 |
0.725 | -0.068 | -5 | 0.681 |
PTK2 |
0.725 | 0.060 | -1 | 0.754 |
LIMK1_TYR |
0.725 | -0.320 | 2 | 0.760 |
BMX |
0.725 | -0.001 | -1 | 0.736 |
MET |
0.724 | -0.071 | 3 | 0.672 |
LTK |
0.724 | -0.063 | 3 | 0.633 |
CDK10 |
0.724 | -0.098 | 1 | 0.569 |
KDR |
0.724 | -0.119 | 3 | 0.645 |
ERBB2 |
0.723 | -0.064 | 1 | 0.714 |
MATK |
0.723 | -0.011 | -1 | 0.816 |
PAK4 |
0.723 | -0.110 | -2 | 0.591 |
PBK |
0.722 | -0.143 | 1 | 0.701 |
PTK6 |
0.722 | -0.081 | -1 | 0.734 |
FGFR1 |
0.722 | -0.121 | 3 | 0.660 |
PTK2B |
0.722 | -0.004 | -1 | 0.798 |
FRK |
0.722 | -0.005 | -1 | 0.854 |
RIPK2 |
0.722 | -0.294 | 1 | 0.692 |
CDK6 |
0.722 | -0.095 | 1 | 0.563 |
PDGFRB |
0.722 | -0.165 | 3 | 0.679 |
CDK4 |
0.722 | -0.086 | 1 | 0.551 |
CSK |
0.721 | 0.003 | 2 | 0.739 |
LYN |
0.721 | 0.004 | 3 | 0.601 |
YSK1 |
0.721 | -0.248 | 2 | 0.693 |
TEK |
0.721 | -0.128 | 3 | 0.622 |
AXL |
0.720 | -0.118 | 3 | 0.665 |
CK1A |
0.720 | -0.038 | -3 | 0.430 |
INSR |
0.719 | -0.070 | 3 | 0.616 |
ALK |
0.719 | -0.104 | 3 | 0.598 |
SRC |
0.719 | 0.016 | -1 | 0.809 |
NTRK3 |
0.719 | -0.034 | -1 | 0.797 |
ASK1 |
0.718 | -0.211 | 1 | 0.709 |
ROCK1 |
0.718 | -0.084 | -3 | 0.699 |
EPHA2 |
0.718 | 0.046 | -1 | 0.797 |
MOK |
0.718 | -0.081 | 1 | 0.643 |
BIKE |
0.718 | -0.065 | 1 | 0.650 |
TNK2 |
0.718 | -0.165 | 3 | 0.648 |
CRIK |
0.717 | -0.056 | -3 | 0.654 |
FLT4 |
0.717 | -0.111 | 3 | 0.659 |
PKN1 |
0.717 | -0.149 | -3 | 0.663 |
NEK10_TYR |
0.717 | -0.157 | 1 | 0.641 |
BTK |
0.717 | -0.129 | -1 | 0.746 |
IGF1R |
0.715 | 0.006 | 3 | 0.571 |
ERBB4 |
0.714 | 0.021 | 1 | 0.652 |
NTRK2 |
0.713 | -0.142 | 3 | 0.641 |
EPHA1 |
0.713 | -0.115 | 3 | 0.639 |
MYO3A |
0.713 | -0.186 | 1 | 0.723 |
STLK3 |
0.713 | -0.175 | 1 | 0.694 |
MYO3B |
0.712 | -0.200 | 2 | 0.698 |
CK1G3 |
0.712 | -0.021 | -3 | 0.387 |
NEK3 |
0.711 | -0.304 | 1 | 0.694 |
HASPIN |
0.711 | -0.125 | -1 | 0.613 |
WEE1_TYR |
0.711 | -0.154 | -1 | 0.732 |
DDR2 |
0.710 | -0.090 | 3 | 0.636 |
JAK1 |
0.709 | -0.188 | 1 | 0.688 |
PDGFRA |
0.709 | -0.284 | 3 | 0.673 |
PKG1 |
0.709 | -0.102 | -2 | 0.574 |
TNK1 |
0.706 | -0.251 | 3 | 0.665 |
TAO1 |
0.706 | -0.221 | 1 | 0.671 |
TNNI3K_TYR |
0.706 | -0.219 | 1 | 0.740 |
YANK2 |
0.701 | -0.060 | 2 | 0.417 |
CK1G2 |
0.700 | -0.001 | -3 | 0.473 |
AAK1 |
0.697 | -0.045 | 1 | 0.545 |
ZAP70 |
0.697 | 0.005 | -1 | 0.709 |
FES |
0.696 | -0.067 | -1 | 0.729 |
MUSK |
0.689 | -0.171 | 1 | 0.600 |