Motif 1119 (n=49)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
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O60330 | PCDHGA12 | Y879 | ochoa | Protocadherin gamma-A12 (PCDH-gamma-A12) (Cadherin-21) (Fibroblast cadherin-3) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
P06213 | INSR | Y1149 | psp | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
P07949 | RET | Y864 | psp | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] | Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:21994944, PubMed:23333276, PubMed:28846097, PubMed:28846099, PubMed:28953886). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:21994944, PubMed:23333276, PubMed:24560924, PubMed:25242331, PubMed:28846097, PubMed:28846099, PubMed:28953886). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20616503, PubMed:21994944). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846099, PubMed:28953886). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (PubMed:21357690). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (PubMed:20064382). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (PubMed:21454698). {ECO:0000250|UniProtKB:P35546, ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503, ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:24560924, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31118272}.; FUNCTION: [Isoform 1]: Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL. {ECO:0000269|PubMed:28846099}. |
P08581 | MET | Y1194 | psp | Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000269|PubMed:11081636, ECO:0000305|PubMed:17662939, ECO:0000305|PubMed:19900460}. |
P52333 | JAK3 | Y939 | psp | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955, ECO:0000269|PubMed:8022485}. |
Q04912 | MST1R | Y1198 | psp | Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. {ECO:0000269|PubMed:18836480, ECO:0000269|PubMed:7939629, ECO:0000269|PubMed:9764835}. |
Q9UN70 | PCDHGC3 | Y881 | ochoa | Protocadherin gamma-C3 (PCDH-gamma-C3) (Protocadherin-2) (Protocadherin-43) (PC-43) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9UN71 | PCDHGB4 | Y870 | ochoa | Protocadherin gamma-B4 (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin-2) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5F6 | PCDHGC5 | Y891 | ochoa | Protocadherin gamma-C5 (PCDH-gamma-C5) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5F7 | PCDHGC4 | Y885 | ochoa | Protocadherin gamma-C4 (PCDH-gamma-C4) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5F8 | PCDHGB7 | Y876 | ochoa | Protocadherin gamma-B7 (PCDH-gamma-B7) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5F9 | PCDHGB6 | Y877 | ochoa | Protocadherin gamma-B6 (PCDH-gamma-B6) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G0 | PCDHGB5 | Y870 | ochoa | Protocadherin gamma-B5 (PCDH-gamma-B5) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G1 | PCDHGB3 | Y876 | ochoa | Protocadherin gamma-B3 (PCDH-gamma-B3) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G2 | PCDHGB2 | Y878 | ochoa | Protocadherin gamma-B2 (PCDH-gamma-B2) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G3 | PCDHGB1 | Y874 | ochoa | Protocadherin gamma-B1 (PCDH-gamma-B1) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G4 | PCDHGA9 | Y879 | ochoa | Protocadherin gamma-A9 (PCDH-gamma-A9) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G5 | PCDHGA8 | Y879 | ochoa | Protocadherin gamma-A8 (PCDH-gamma-A8) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G6 | PCDHGA7 | Y879 | ochoa | Protocadherin gamma-A7 (PCDH-gamma-A7) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G7 | PCDHGA6 | Y879 | ochoa | Protocadherin gamma-A6 (PCDH-gamma-A6) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5G8 | PCDHGA5 | Y878 | ochoa | Protocadherin gamma-A5 (PCDH-gamma-A5) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5H0 | PCDHGA3 | Y879 | ochoa | Protocadherin gamma-A3 (PCDH-gamma-A3) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5H1 | PCDHGA2 | Y879 | ochoa | Protocadherin gamma-A2 (PCDH-gamma-A2) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5H2 | PCDHGA11 | Y882 | ochoa | Protocadherin gamma-A11 (PCDH-gamma-A11) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5H3 | PCDHGA10 | Y883 | ochoa | Protocadherin gamma-A10 (PCDH-gamma-A10) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
Q9Y5H4 | PCDHGA1 | Y878 | ochoa | Protocadherin gamma-A1 (PCDH-gamma-A1) | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
O15146 | MUSK | Y715 | Sugiyama | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}. |
P29322 | EPHA8 | Y750 | Sugiyama | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
O60674 | JAK2 | Y966 | SIGNOR | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:15690087, PubMed:7615558, PubMed:9657743, PubMed:15899890). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:15690087, PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain (PubMed:9657743). Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). Up-regulates the potassium voltage-gated channel activity of KCNA3 (PubMed:25644777). {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:15690087, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20098430, ECO:0000269|PubMed:21368206, ECO:0000269|PubMed:21423214, ECO:0000269|PubMed:25644777, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263, ECO:0000269|PubMed:9657743}. |
P00533 | EGFR | Y827 | Sugiyama | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
P21802 | FGFR2 | Y616 | Sugiyama | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}. |
P22607 | FGFR3 | Y607 | Sugiyama | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}. |
P22455 | FGFR4 | Y602 | Sugiyama | Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) | Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. {ECO:0000269|PubMed:11433297, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:18670643, ECO:0000269|PubMed:20018895, ECO:0000269|PubMed:20683963, ECO:0000269|PubMed:20798051, ECO:0000269|PubMed:20876804, ECO:0000269|PubMed:21653700, ECO:0000269|PubMed:7518429, ECO:0000269|PubMed:7680645, ECO:0000269|PubMed:8663044}. |
P23458 | JAK1 | Y993 | Sugiyama | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16239216, ECO:0000269|PubMed:28111307, ECO:0000269|PubMed:32750333, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:8232552}. |
P29317 | EPHA2 | Y729 | Sugiyama | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
P29320 | EPHA3 | Y736 | Sugiyama | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
P54756 | EPHA5 | Y790 | Sugiyama | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}. |
P29323 | EPHB2 | Y736 | Sugiyama | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
P41240 | CSK | Y304 | SIGNOR|iPTMNet | Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL) | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}. |
P42680 | TEC | Y479 | Sugiyama | Tyrosine-protein kinase Tec (EC 2.7.10.2) | Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC also regulates FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. {ECO:0000269|PubMed:10518561, ECO:0000269|PubMed:19883687, ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:9753425}. |
P42681 | TXK | Y380 | Sugiyama | Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase) | Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Also contributes to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Also phosphorylates key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. {ECO:0000269|PubMed:10523612, ECO:0000269|PubMed:11564877, ECO:0000269|PubMed:11859127, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:9813138}. |
P43405 | SYK | Y484 | Sugiyama | Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) | Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:34634301, PubMed:8657103). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Also plays a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
P54753 | EPHB3 | Y748 | Sugiyama | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}. |
P54760 | EPHB4 | Y730 | Sugiyama | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
P54764 | EPHA4 | Y736 | Sugiyama | Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) | Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (By similarity). {ECO:0000250|UniProtKB:Q03137, ECO:0000269|PubMed:17143272}. |
Q06187 | BTK | Y511 | Sugiyama | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
Q15303 | ERBB4 | Y833 | Sugiyama | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
Q15375 | EPHA7 | Y748 | Sugiyama | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. |
Q9UM73 | ALK | Y1239 | Sugiyama | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a negative regulator of white adipose tissue lipolysis and sympathetic tone to fine-tune energy homeostasis (By similarity). Following activation by ALKAL2 ligand at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). In contrast, ALKAL1 is not a potent physiological ligand for ALK (PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:34819673). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (PubMed:15226403, PubMed:16878150). Induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1 (PubMed:15226403, PubMed:16878150). ALK activation may also be regulated by pleiotrophin (PTN) and midkine (MDK) (PubMed:11278720, PubMed:11809760, PubMed:12107166, PubMed:12122009). PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720, PubMed:11809760, PubMed:12107166). MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction (PubMed:12122009). Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase (PubMed:15226403, PubMed:16878150). Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK (PubMed:15226403, PubMed:16878150). {ECO:0000250|UniProtKB:P97793, ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760, ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009, ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:17274988, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.142730e-14 | 13.669 |
R-HSA-5673001 | RAF/MAP kinase cascade | 1.498801e-14 | 13.824 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.357803e-13 | 12.867 |
R-HSA-5683057 | MAPK family signaling cascades | 2.328138e-13 | 12.633 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 8.092416e-13 | 12.092 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.054379e-12 | 11.977 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.557532e-12 | 11.808 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.980727e-12 | 11.526 |
R-HSA-1226099 | Signaling by FGFR in disease | 3.032685e-12 | 11.518 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.491541e-12 | 11.071 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.323186e-11 | 10.878 |
R-HSA-2682334 | EPH-Ephrin signaling | 6.605329e-10 | 9.180 |
R-HSA-74751 | Insulin receptor signalling cascade | 1.047967e-09 | 8.980 |
R-HSA-109704 | PI3K Cascade | 6.978559e-09 | 8.156 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 7.949377e-09 | 8.100 |
R-HSA-1257604 | PIP3 activates AKT signaling | 9.827618e-09 | 8.008 |
R-HSA-74752 | Signaling by Insulin receptor | 1.536635e-08 | 7.813 |
R-HSA-112399 | IRS-mediated signalling | 1.513287e-08 | 7.820 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.267873e-08 | 7.644 |
R-HSA-2428924 | IGF1R signaling cascade | 3.024219e-08 | 7.519 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 3.319576e-08 | 7.479 |
R-HSA-1839126 | FGFR2 mutant receptor activation | 3.762753e-08 | 7.424 |
R-HSA-9006925 | Intracellular signaling by second messengers | 4.463753e-08 | 7.350 |
R-HSA-8851708 | Signaling by FGFR2 IIIa TM | 7.633561e-08 | 7.117 |
R-HSA-5655253 | Signaling by FGFR2 in disease | 2.154945e-07 | 6.667 |
R-HSA-190236 | Signaling by FGFR | 4.865608e-07 | 6.313 |
R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.273514e-06 | 5.895 |
R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.575897e-06 | 5.802 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.336632e-06 | 5.631 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.749049e-06 | 5.561 |
R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 4.633129e-06 | 5.334 |
R-HSA-422475 | Axon guidance | 4.838009e-06 | 5.315 |
R-HSA-190241 | FGFR2 ligand binding and activation | 5.402669e-06 | 5.267 |
R-HSA-9675108 | Nervous system development | 9.142932e-06 | 5.039 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 9.453737e-06 | 5.024 |
R-HSA-5654695 | PI-3K cascade:FGFR2 | 1.074401e-05 | 4.969 |
R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.370813e-05 | 4.863 |
R-HSA-5654700 | FRS-mediated FGFR2 signaling | 1.539713e-05 | 4.813 |
R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.614607e-05 | 4.792 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.723447e-05 | 4.764 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.922815e-05 | 4.716 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.922815e-05 | 4.716 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.922815e-05 | 4.716 |
R-HSA-1236394 | Signaling by ERBB4 | 2.934322e-05 | 4.532 |
R-HSA-5654727 | Negative regulation of FGFR2 signaling | 3.183272e-05 | 4.497 |
R-HSA-9020558 | Interleukin-2 signaling | 3.298190e-05 | 4.482 |
R-HSA-5654696 | Downstream signaling of activated FGFR2 | 3.494122e-05 | 4.457 |
R-HSA-1251985 | Nuclear signaling by ERBB4 | 5.391963e-05 | 4.268 |
R-HSA-451927 | Interleukin-2 family signaling | 5.391963e-05 | 4.268 |
R-HSA-2033514 | FGFR3 mutant receptor activation | 5.851174e-05 | 4.233 |
R-HSA-1839130 | Signaling by activated point mutants of FGFR3 | 5.851174e-05 | 4.233 |
R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.089507e-04 | 3.963 |
R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.248848e-04 | 3.903 |
R-HSA-3928664 | Ephrin signaling | 1.422640e-04 | 3.847 |
R-HSA-2033519 | Activated point mutants of FGFR2 | 1.422640e-04 | 3.847 |
R-HSA-162582 | Signal Transduction | 2.134611e-04 | 3.671 |
R-HSA-1227986 | Signaling by ERBB2 | 2.208444e-04 | 3.656 |
R-HSA-2023837 | Signaling by FGFR2 amplification mutants | 2.230672e-04 | 3.652 |
R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 2.273441e-04 | 3.643 |
R-HSA-8848021 | Signaling by PTK6 | 2.599575e-04 | 3.585 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 2.599575e-04 | 3.585 |
R-HSA-912526 | Interleukin receptor SHC signaling | 2.799808e-04 | 3.553 |
R-HSA-8854691 | Interleukin-20 family signaling | 2.799808e-04 | 3.553 |
R-HSA-9620244 | Long-term potentiation | 3.399084e-04 | 3.469 |
R-HSA-5655332 | Signaling by FGFR3 in disease | 4.075324e-04 | 3.390 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.832467e-04 | 3.316 |
R-HSA-5654738 | Signaling by FGFR2 | 5.809314e-04 | 3.236 |
R-HSA-9679191 | Potential therapeutics for SARS | 7.980141e-04 | 3.098 |
R-HSA-9732724 | IFNG signaling activates MAPKs | 8.800068e-04 | 3.056 |
R-HSA-201556 | Signaling by ALK | 1.060835e-03 | 2.974 |
R-HSA-8985947 | Interleukin-9 signaling | 1.061868e-03 | 2.974 |
R-HSA-9020958 | Interleukin-21 signaling | 1.260223e-03 | 2.900 |
R-HSA-112411 | MAPK1 (ERK2) activation | 1.260223e-03 | 2.900 |
R-HSA-9020956 | Interleukin-27 signaling | 1.474930e-03 | 2.831 |
R-HSA-110056 | MAPK3 (ERK1) activation | 1.474930e-03 | 2.831 |
R-HSA-3928662 | EPHB-mediated forward signaling | 1.504655e-03 | 2.823 |
R-HSA-190377 | FGFR2b ligand binding and activation | 1.705850e-03 | 2.768 |
R-HSA-1250342 | PI3K events in ERBB4 signaling | 1.952846e-03 | 2.709 |
R-HSA-190375 | FGFR2c ligand binding and activation | 2.494513e-03 | 2.603 |
R-HSA-8983432 | Interleukin-15 signaling | 2.215779e-03 | 2.654 |
R-HSA-8984722 | Interleukin-35 Signalling | 2.215779e-03 | 2.654 |
R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 2.494513e-03 | 2.603 |
R-HSA-1059683 | Interleukin-6 signaling | 2.494513e-03 | 2.603 |
R-HSA-877312 | Regulation of IFNG signaling | 2.215779e-03 | 2.654 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 2.352954e-03 | 2.628 |
R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 | 2.788911e-03 | 2.555 |
R-HSA-190239 | FGFR3 ligand binding and activation | 3.098838e-03 | 2.509 |
R-HSA-1643685 | Disease | 3.120213e-03 | 2.506 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 3.764745e-03 | 2.424 |
R-HSA-9700649 | Drug resistance of ALK mutants | 4.275881e-03 | 2.369 |
R-HSA-9717264 | ASP-3026-resistant ALK mutants | 4.275881e-03 | 2.369 |
R-HSA-9717301 | NVP-TAE684-resistant ALK mutants | 4.275881e-03 | 2.369 |
R-HSA-9717329 | lorlatinib-resistant ALK mutants | 4.275881e-03 | 2.369 |
R-HSA-9717316 | alectinib-resistant ALK mutants | 4.275881e-03 | 2.369 |
R-HSA-9717319 | brigatinib-resistant ALK mutants | 4.275881e-03 | 2.369 |
R-HSA-9717326 | crizotinib-resistant ALK mutants | 4.275881e-03 | 2.369 |
R-HSA-9717323 | ceritinib-resistant ALK mutants | 4.275881e-03 | 2.369 |
R-HSA-180292 | GAB1 signalosome | 4.491169e-03 | 2.348 |
R-HSA-5654710 | PI-3K cascade:FGFR3 | 4.876746e-03 | 2.312 |
R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 5.691980e-03 | 2.245 |
R-HSA-5654706 | FRS-mediated FGFR3 signaling | 6.121378e-03 | 2.213 |
R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 6.121378e-03 | 2.213 |
R-HSA-112409 | RAF-independent MAPK1/3 activation | 6.565128e-03 | 2.183 |
R-HSA-9734091 | Drug-mediated inhibition of MET activation | 8.533743e-03 | 2.069 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.006263e-02 | 1.997 |
R-HSA-5654708 | Downstream signaling of activated FGFR3 | 1.006263e-02 | 1.997 |
R-HSA-6783589 | Interleukin-6 family signaling | 7.495171e-03 | 2.125 |
R-HSA-2424491 | DAP12 signaling | 1.061668e-02 | 1.974 |
R-HSA-1266695 | Interleukin-7 signaling | 7.981214e-03 | 2.098 |
R-HSA-5654732 | Negative regulation of FGFR3 signaling | 9.521935e-03 | 2.021 |
R-HSA-9830364 | Formation of the nephric duct | 7.981214e-03 | 2.098 |
R-HSA-1266738 | Developmental Biology | 8.082243e-03 | 2.092 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 8.481105e-03 | 2.072 |
R-HSA-438064 | Post NMDA receptor activation events | 8.283358e-03 | 2.082 |
R-HSA-354192 | Integrin signaling | 1.235778e-02 | 1.908 |
R-HSA-1839128 | FGFR4 mutant receptor activation | 1.277366e-02 | 1.894 |
R-HSA-2033515 | t(4;14) translocations of FGFR3 | 1.277366e-02 | 1.894 |
R-HSA-8853333 | Signaling by FGFR2 fusions | 1.277366e-02 | 1.894 |
R-HSA-8853334 | Signaling by FGFR3 fusions in cancer | 1.277366e-02 | 1.894 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.283289e-02 | 1.892 |
R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.358310e-02 | 1.867 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 1.536033e-02 | 1.814 |
R-HSA-9607240 | FLT3 Signaling | 1.826401e-02 | 1.738 |
R-HSA-9656223 | Signaling by RAF1 mutants | 1.898100e-02 | 1.722 |
R-HSA-1433557 | Signaling by SCF-KIT | 2.045007e-02 | 1.689 |
R-HSA-8875513 | MET interacts with TNS proteins | 2.119996e-02 | 1.674 |
R-HSA-8865999 | MET activates PTPN11 | 2.119996e-02 | 1.674 |
R-HSA-8875791 | MET activates STAT3 | 2.119996e-02 | 1.674 |
R-HSA-2172127 | DAP12 interactions | 2.120194e-02 | 1.674 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.120194e-02 | 1.674 |
R-HSA-5654741 | Signaling by FGFR3 | 2.196521e-02 | 1.658 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.196521e-02 | 1.658 |
R-HSA-9824272 | Somitogenesis | 2.196521e-02 | 1.658 |
R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.273978e-02 | 1.643 |
R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.273978e-02 | 1.643 |
R-HSA-9649948 | Signaling downstream of RAS mutants | 2.273978e-02 | 1.643 |
R-HSA-6802949 | Signaling by RAS mutants | 2.273978e-02 | 1.643 |
R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 2.538649e-02 | 1.595 |
R-HSA-1307965 | betaKlotho-mediated ligand binding | 2.538649e-02 | 1.595 |
R-HSA-9851151 | MDK and PTN in ALK signaling | 2.538649e-02 | 1.595 |
R-HSA-9706374 | FLT3 signaling through SRC family kinases | 2.538649e-02 | 1.595 |
R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 2.761850e-02 | 1.559 |
R-HSA-74713 | IRS activation | 2.955537e-02 | 1.529 |
R-HSA-177929 | Signaling by EGFR | 3.108358e-02 | 1.507 |
R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 3.370668e-02 | 1.472 |
R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 3.370668e-02 | 1.472 |
R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 3.784048e-02 | 1.422 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 3.784048e-02 | 1.422 |
R-HSA-8851907 | MET activates PI3K/AKT signaling | 4.195686e-02 | 1.377 |
R-HSA-190371 | FGFR3b ligand binding and activation | 4.195686e-02 | 1.377 |
R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 4.605588e-02 | 1.337 |
R-HSA-8875656 | MET receptor recycling | 4.605588e-02 | 1.337 |
R-HSA-9700645 | ALK mutants bind TKIs | 5.013761e-02 | 1.300 |
R-HSA-8875555 | MET activates RAP1 and RAC1 | 5.420213e-02 | 1.266 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 5.420213e-02 | 1.266 |
R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 6.227982e-02 | 1.206 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.946432e-02 | 1.404 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 5.287885e-02 | 1.277 |
R-HSA-2586552 | Signaling by Leptin | 5.420213e-02 | 1.266 |
R-HSA-8852405 | Signaling by MST1 | 3.370668e-02 | 1.472 |
R-HSA-9020933 | Interleukin-23 signaling | 4.605588e-02 | 1.337 |
R-HSA-6802957 | Oncogenic MAPK signaling | 6.068114e-02 | 1.217 |
R-HSA-6806942 | MET Receptor Activation | 3.784048e-02 | 1.422 |
R-HSA-2179392 | EGFR Transactivation by Gastrin | 5.420213e-02 | 1.266 |
R-HSA-447115 | Interleukin-12 family signaling | 6.413913e-02 | 1.193 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.233499e-02 | 1.205 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 4.650572e-02 | 1.332 |
R-HSA-9020591 | Interleukin-12 signaling | 5.072116e-02 | 1.295 |
R-HSA-74749 | Signal attenuation | 5.420213e-02 | 1.266 |
R-HSA-9830369 | Kidney development | 4.143118e-02 | 1.383 |
R-HSA-9793380 | Formation of paraxial mesoderm | 3.564263e-02 | 1.448 |
R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 4.242829e-02 | 1.372 |
R-HSA-8851805 | MET activates RAS signaling | 6.629313e-02 | 1.179 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 6.629313e-02 | 1.179 |
R-HSA-179812 | GRB2 events in EGFR signaling | 6.629313e-02 | 1.179 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 6.885092e-02 | 1.162 |
R-HSA-190322 | FGFR4 ligand binding and activation | 7.028951e-02 | 1.153 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.245781e-02 | 1.140 |
R-HSA-5655291 | Signaling by FGFR4 in disease | 7.426904e-02 | 1.129 |
R-HSA-1170546 | Prolactin receptor signaling | 7.426904e-02 | 1.129 |
R-HSA-190372 | FGFR3c ligand binding and activation | 7.426904e-02 | 1.129 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 7.787686e-02 | 1.109 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 7.823177e-02 | 1.107 |
R-HSA-9027284 | Erythropoietin activates RAS | 7.823177e-02 | 1.107 |
R-HSA-180336 | SHC1 events in EGFR signaling | 7.823177e-02 | 1.107 |
R-HSA-5654228 | Phospholipase C-mediated cascade; FGFR4 | 7.823177e-02 | 1.107 |
R-HSA-8964315 | G beta:gamma signalling through BTK | 7.823177e-02 | 1.107 |
R-HSA-9706369 | Negative regulation of FLT3 | 8.217779e-02 | 1.085 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 9.001995e-02 | 1.046 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 9.001995e-02 | 1.046 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 9.391623e-02 | 1.027 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 9.397507e-02 | 1.027 |
R-HSA-912631 | Regulation of signaling by CBL | 9.779606e-02 | 1.010 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 9.779606e-02 | 1.010 |
R-HSA-449836 | Other interleukin signaling | 9.779606e-02 | 1.010 |
R-HSA-8939211 | ESR-mediated signaling | 9.836168e-02 | 1.007 |
R-HSA-9679506 | SARS-CoV Infections | 1.009154e-01 | 0.996 |
R-HSA-6807004 | Negative regulation of MET activity | 1.016595e-01 | 0.993 |
R-HSA-5654720 | PI-3K cascade:FGFR4 | 1.016595e-01 | 0.993 |
R-HSA-445144 | Signal transduction by L1 | 1.016595e-01 | 0.993 |
R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.055067e-01 | 0.977 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.055067e-01 | 0.977 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.055067e-01 | 0.977 |
R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 1.055067e-01 | 0.977 |
R-HSA-373760 | L1CAM interactions | 1.073907e-01 | 0.969 |
R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 1.093376e-01 | 0.961 |
R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.093376e-01 | 0.961 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.093376e-01 | 0.961 |
R-HSA-5654712 | FRS-mediated FGFR4 signaling | 1.131524e-01 | 0.946 |
R-HSA-912694 | Regulation of IFNA/IFNB signaling | 1.131524e-01 | 0.946 |
R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.131524e-01 | 0.946 |
R-HSA-9669938 | Signaling by KIT in disease | 1.131524e-01 | 0.946 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.131524e-01 | 0.946 |
R-HSA-982772 | Growth hormone receptor signaling | 1.169510e-01 | 0.932 |
R-HSA-9830674 | Formation of the ureteric bud | 1.169510e-01 | 0.932 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.169510e-01 | 0.932 |
R-HSA-400685 | Sema4D in semaphorin signaling | 1.245003e-01 | 0.905 |
R-HSA-8874081 | MET activates PTK2 signaling | 1.282510e-01 | 0.892 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 1.282510e-01 | 0.892 |
R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 1.319859e-01 | 0.879 |
R-HSA-212436 | Generic Transcription Pathway | 1.330970e-01 | 0.876 |
R-HSA-77387 | Insulin receptor recycling | 1.357050e-01 | 0.867 |
R-HSA-9006335 | Signaling by Erythropoietin | 1.394084e-01 | 0.856 |
R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.394084e-01 | 0.856 |
R-HSA-9018519 | Estrogen-dependent gene expression | 1.399601e-01 | 0.854 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.414221e-01 | 0.849 |
R-HSA-5654716 | Downstream signaling of activated FGFR4 | 1.430962e-01 | 0.844 |
R-HSA-449147 | Signaling by Interleukins | 1.434553e-01 | 0.843 |
R-HSA-9664407 | Parasite infection | 1.458280e-01 | 0.836 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.458280e-01 | 0.836 |
R-HSA-9664417 | Leishmania phagocytosis | 1.458280e-01 | 0.836 |
R-HSA-182971 | EGFR downregulation | 1.467684e-01 | 0.833 |
R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 1.467684e-01 | 0.833 |
R-HSA-9833109 | Evasion by RSV of host interferon responses | 1.467684e-01 | 0.833 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.473032e-01 | 0.832 |
R-HSA-397795 | G-protein beta:gamma signalling | 1.540664e-01 | 0.812 |
R-HSA-9758941 | Gastrulation | 1.607143e-01 | 0.794 |
R-HSA-5673000 | RAF activation | 1.613028e-01 | 0.792 |
R-HSA-9856651 | MITF-M-dependent gene expression | 1.622185e-01 | 0.790 |
R-HSA-8853659 | RET signaling | 1.684783e-01 | 0.773 |
R-HSA-114604 | GPVI-mediated activation cascade | 1.684783e-01 | 0.773 |
R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.720432e-01 | 0.764 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.743427e-01 | 0.759 |
R-HSA-8875878 | MET promotes cell motility | 1.755932e-01 | 0.755 |
R-HSA-877300 | Interferon gamma signaling | 1.758689e-01 | 0.755 |
R-HSA-112315 | Transmission across Chemical Synapses | 1.821548e-01 | 0.740 |
R-HSA-5260271 | Diseases of Immune System | 1.826481e-01 | 0.738 |
R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.826481e-01 | 0.738 |
R-HSA-5674135 | MAP2K and MAPK activation | 1.896435e-01 | 0.722 |
R-HSA-73857 | RNA Polymerase II Transcription | 1.958892e-01 | 0.708 |
R-HSA-5654743 | Signaling by FGFR4 | 1.965799e-01 | 0.706 |
R-HSA-69231 | Cyclin D associated events in G1 | 2.000261e-01 | 0.699 |
R-HSA-69236 | G1 Phase | 2.000261e-01 | 0.699 |
R-HSA-3214858 | RMTs methylate histone arginines | 2.000261e-01 | 0.699 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.005566e-01 | 0.698 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 2.261720e-01 | 0.646 |
R-HSA-9012852 | Signaling by NOTCH3 | 2.369862e-01 | 0.625 |
R-HSA-389948 | Co-inhibition by PD-1 | 2.414318e-01 | 0.617 |
R-HSA-5621480 | Dectin-2 family | 2.435230e-01 | 0.613 |
R-HSA-373755 | Semaphorin interactions | 2.628042e-01 | 0.580 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.636363e-01 | 0.579 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 2.842767e-01 | 0.546 |
R-HSA-3000178 | ECM proteoglycans | 2.877608e-01 | 0.541 |
R-HSA-1169408 | ISG15 antiviral mechanism | 2.999250e-01 | 0.523 |
R-HSA-6783783 | Interleukin-10 signaling | 3.089135e-01 | 0.510 |
R-HSA-416482 | G alpha (12/13) signalling events | 3.089135e-01 | 0.510 |
R-HSA-6806834 | Signaling by MET | 3.148426e-01 | 0.502 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 3.281737e-01 | 0.484 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 3.316551e-01 | 0.479 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 3.323307e-01 | 0.478 |
R-HSA-9734767 | Developmental Cell Lineages | 3.426080e-01 | 0.465 |
R-HSA-1236974 | ER-Phagosome pathway | 3.437443e-01 | 0.464 |
R-HSA-416476 | G alpha (q) signalling events | 3.441685e-01 | 0.463 |
R-HSA-74160 | Gene expression (Transcription) | 3.461401e-01 | 0.461 |
R-HSA-112316 | Neuronal System | 3.494854e-01 | 0.457 |
R-HSA-2029481 | FCGR activation | 3.577412e-01 | 0.446 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 3.597089e-01 | 0.444 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.687265e-01 | 0.433 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 3.687265e-01 | 0.433 |
R-HSA-9824446 | Viral Infection Pathways | 3.692284e-01 | 0.433 |
R-HSA-9824443 | Parasitic Infection Pathways | 3.705112e-01 | 0.431 |
R-HSA-9658195 | Leishmania infection | 3.705112e-01 | 0.431 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 3.821980e-01 | 0.418 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.901445e-01 | 0.409 |
R-HSA-9833110 | RSV-host interactions | 3.927709e-01 | 0.406 |
R-HSA-9700206 | Signaling by ALK in cancer | 4.005834e-01 | 0.397 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.005834e-01 | 0.397 |
R-HSA-1236975 | Antigen processing-Cross presentation | 4.031655e-01 | 0.395 |
R-HSA-202403 | TCR signaling | 4.082968e-01 | 0.389 |
R-HSA-2871796 | FCERI mediated MAPK activation | 4.133846e-01 | 0.384 |
R-HSA-909733 | Interferon alpha/beta signaling | 4.259163e-01 | 0.371 |
R-HSA-2029485 | Role of phospholipids in phagocytosis | 4.259163e-01 | 0.371 |
R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.357514e-01 | 0.361 |
R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.357514e-01 | 0.361 |
R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.430185e-01 | 0.354 |
R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.430185e-01 | 0.354 |
R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 4.549260e-01 | 0.342 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.979298e-01 | 0.303 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 5.000981e-01 | 0.301 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.065477e-01 | 0.295 |
R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 5.108019e-01 | 0.292 |
R-HSA-913531 | Interferon Signaling | 5.192005e-01 | 0.285 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.233486e-01 | 0.281 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 5.591167e-01 | 0.252 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.610244e-01 | 0.251 |
R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 5.629238e-01 | 0.250 |
R-HSA-9664433 | Leishmania parasite growth and survival | 5.629238e-01 | 0.250 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.666986e-01 | 0.247 |
R-HSA-168898 | Toll-like Receptor Cascades | 5.957619e-01 | 0.225 |
R-HSA-9609690 | HCMV Early Events | 6.044438e-01 | 0.219 |
R-HSA-5663205 | Infectious disease | 6.097098e-01 | 0.215 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 6.573093e-01 | 0.182 |
R-HSA-3247509 | Chromatin modifying enzymes | 6.661434e-01 | 0.176 |
R-HSA-157118 | Signaling by NOTCH | 6.747529e-01 | 0.171 |
R-HSA-109582 | Hemostasis | 6.767057e-01 | 0.170 |
R-HSA-1280218 | Adaptive Immune System | 6.785887e-01 | 0.168 |
R-HSA-4839726 | Chromatin organization | 6.872585e-01 | 0.163 |
R-HSA-9609646 | HCMV Infection | 6.886184e-01 | 0.162 |
R-HSA-1474244 | Extracellular matrix organization | 7.814279e-01 | 0.107 |
R-HSA-9694516 | SARS-CoV-2 Infection | 7.980088e-01 | 0.098 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.267798e-01 | 0.083 |
R-HSA-9824439 | Bacterial Infection Pathways | 8.320291e-01 | 0.080 |
R-HSA-168249 | Innate Immune System | 8.404399e-01 | 0.075 |
R-HSA-388396 | GPCR downstream signalling | 8.606862e-01 | 0.065 |
R-HSA-372790 | Signaling by GPCR | 8.959991e-01 | 0.048 |
R-HSA-69278 | Cell Cycle, Mitotic | 9.228678e-01 | 0.035 |
R-HSA-168256 | Immune System | 9.287113e-01 | 0.032 |
R-HSA-199991 | Membrane Trafficking | 9.464885e-01 | 0.024 |
R-HSA-1640170 | Cell Cycle | 9.590998e-01 | 0.018 |
R-HSA-5653656 | Vesicle-mediated transport | 9.739280e-01 | 0.011 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
NEK10_TYR |
0.457 | 0.102 | 1 | 0.239 |
LIMK2_TYR |
0.451 | 0.084 | -3 | 0.289 |
PDHK3_TYR |
0.448 | 0.082 | 4 | 0.428 |
TNNI3K_TYR |
0.447 | 0.032 | 1 | 0.184 |
TESK1_TYR |
0.446 | 0.027 | 3 | 0.490 |
TNK1 |
0.444 | 0.098 | 3 | 0.346 |
LIMK1_TYR |
0.442 | 0.028 | 2 | 0.396 |
RET |
0.440 | -0.002 | 1 | 0.214 |
PKMYT1_TYR |
0.439 | -0.001 | 3 | 0.422 |
MAP2K7_TYR |
0.438 | -0.031 | 2 | 0.397 |
TYK2 |
0.438 | 0.008 | 1 | 0.240 |
MAP2K4_TYR |
0.438 | -0.024 | -1 | 0.408 |
PDHK4_TYR |
0.437 | -0.049 | 2 | 0.421 |
JAK1 |
0.434 | 0.034 | 1 | 0.245 |
MAP2K6_TYR |
0.434 | -0.076 | -1 | 0.424 |
PINK1_TYR |
0.432 | -0.119 | 1 | 0.186 |
PDHK1_TYR |
0.432 | -0.081 | -1 | 0.435 |
ABL2 |
0.431 | -0.029 | -1 | 0.347 |
TNK2 |
0.431 | 0.030 | 3 | 0.293 |
ROS1 |
0.431 | -0.021 | 3 | 0.347 |
FGR |
0.430 | -0.025 | 1 | 0.280 |
DDR1 |
0.428 | -0.037 | 4 | 0.509 |
JAK2 |
0.428 | -0.044 | 1 | 0.223 |
BMPR2_TYR |
0.427 | -0.098 | -1 | 0.396 |
MST1R |
0.427 | -0.065 | 3 | 0.355 |
ABL1 |
0.426 | -0.044 | -1 | 0.331 |
BLK |
0.426 | -0.005 | -1 | 0.309 |
YES1 |
0.425 | -0.039 | -1 | 0.317 |
LCK |
0.425 | -0.014 | -1 | 0.278 |
JAK3 |
0.424 | -0.084 | 1 | 0.153 |
EPHA6 |
0.422 | -0.077 | -1 | 0.380 |
HCK |
0.422 | -0.042 | -1 | 0.273 |
CSF1R |
0.420 | -0.082 | 3 | 0.329 |
TYRO3 |
0.420 | -0.109 | 3 | 0.373 |
EPHB4 |
0.418 | -0.101 | -1 | 0.343 |
FER |
0.415 | -0.125 | 1 | 0.200 |
WEE1_TYR |
0.414 | -0.079 | -1 | 0.328 |
PDGFRA |
0.413 | -0.104 | 3 | 0.342 |
AXL |
0.412 | -0.093 | 3 | 0.350 |
TXK |
0.411 | -0.115 | 1 | 0.155 |
PDGFRB |
0.411 | -0.152 | 3 | 0.361 |
ITK |
0.410 | -0.126 | -1 | 0.275 |
KDR |
0.410 | -0.121 | 3 | 0.308 |
PTK6 |
0.410 | -0.111 | -1 | 0.245 |
EPHA1 |
0.410 | -0.078 | 3 | 0.308 |
FLT3 |
0.409 | -0.148 | 3 | 0.356 |
ALK |
0.409 | -0.094 | 3 | 0.285 |
INSRR |
0.409 | -0.138 | 3 | 0.324 |
EPHB3 |
0.409 | -0.114 | -1 | 0.318 |
BTK |
0.409 | -0.133 | -1 | 0.250 |
FGFR1 |
0.409 | -0.135 | 3 | 0.355 |
DDR2 |
0.408 | -0.085 | 3 | 0.292 |
FGFR2 |
0.408 | -0.148 | 3 | 0.361 |
KIT |
0.408 | -0.132 | 3 | 0.332 |
FYN |
0.408 | -0.067 | -1 | 0.244 |
MERTK |
0.407 | -0.109 | 3 | 0.345 |
TEK |
0.407 | -0.133 | 3 | 0.299 |
SRMS |
0.407 | -0.143 | 1 | 0.170 |
LYN |
0.406 | -0.083 | 3 | 0.279 |
LTK |
0.406 | -0.110 | 3 | 0.297 |
ERBB2 |
0.405 | -0.119 | 1 | 0.182 |
MET |
0.405 | -0.131 | 3 | 0.325 |
FRK |
0.405 | -0.107 | -1 | 0.333 |
EGFR |
0.404 | -0.093 | 1 | 0.107 |
SRC |
0.403 | -0.073 | -1 | 0.250 |
BMX |
0.403 | -0.113 | -1 | 0.234 |
EPHB2 |
0.402 | -0.148 | -1 | 0.318 |
INSR |
0.402 | -0.132 | 3 | 0.300 |
EPHA4 |
0.402 | -0.136 | 2 | 0.351 |
TEC |
0.402 | -0.133 | -1 | 0.243 |
MATK |
0.400 | -0.116 | -1 | 0.372 |
MUSK |
0.400 | -0.097 | 1 | 0.145 |
EPHB1 |
0.399 | -0.176 | 1 | 0.157 |
EPHA7 |
0.398 | -0.126 | 2 | 0.335 |
NTRK3 |
0.397 | -0.128 | -1 | 0.291 |
NTRK1 |
0.397 | -0.169 | -1 | 0.326 |
CSK |
0.397 | -0.125 | 2 | 0.341 |
FLT4 |
0.397 | -0.159 | 3 | 0.311 |
FLT1 |
0.397 | -0.172 | -1 | 0.384 |
EPHA3 |
0.396 | -0.132 | 2 | 0.317 |
NTRK2 |
0.396 | -0.177 | 3 | 0.322 |
FGFR3 |
0.394 | -0.171 | 3 | 0.334 |
FGFR4 |
0.392 | -0.122 | -1 | 0.321 |
AAK1 |
0.391 | 0.257 | 1 | 0.570 |
EPHA8 |
0.389 | -0.140 | -1 | 0.312 |
PTK2B |
0.388 | -0.138 | -1 | 0.275 |
EPHA5 |
0.388 | -0.153 | 2 | 0.327 |
IGF1R |
0.384 | -0.143 | 3 | 0.259 |
BIKE |
0.384 | 0.251 | 1 | 0.531 |
SYK |
0.383 | -0.150 | -1 | 0.304 |
ERBB4 |
0.381 | -0.121 | 1 | 0.111 |
PTK2 |
0.380 | -0.130 | -1 | 0.299 |
ZAP70 |
0.377 | -0.113 | -1 | 0.267 |
EPHA2 |
0.377 | -0.153 | -1 | 0.285 |
PBK |
0.375 | 0.232 | 1 | 0.485 |
PRKD1 |
0.373 | 0.133 | -3 | 0.261 |
FES |
0.372 | -0.144 | -1 | 0.211 |
LKB1 |
0.370 | 0.203 | -3 | 0.334 |
KHS1 |
0.370 | 0.208 | 1 | 0.365 |
CAMKK2 |
0.369 | 0.187 | -2 | 0.319 |
TSSK1 |
0.368 | 0.119 | -3 | 0.264 |
NEK2 |
0.367 | 0.170 | 2 | 0.368 |
PRP4 |
0.367 | 0.222 | -3 | 0.582 |
PRKD2 |
0.366 | 0.092 | -3 | 0.204 |
KHS2 |
0.366 | 0.173 | 1 | 0.368 |
AURC |
0.366 | 0.091 | -2 | 0.119 |
TNIK |
0.365 | 0.154 | 3 | 0.447 |
HUNK |
0.365 | 0.171 | 2 | 0.343 |
CHAK1 |
0.363 | 0.157 | 2 | 0.401 |
NEK5 |
0.362 | 0.176 | 1 | 0.263 |
CAMKK1 |
0.362 | 0.159 | -2 | 0.317 |
MPSK1 |
0.361 | 0.141 | 1 | 0.369 |
HASPIN |
0.361 | 0.202 | -1 | 0.742 |
NEK4 |
0.361 | 0.185 | 1 | 0.315 |
TBK1 |
0.360 | 0.189 | 1 | 0.343 |
DYRK1B |
0.360 | 0.049 | 1 | 0.155 |
SSTK |
0.360 | 0.098 | 4 | 0.530 |
IKKE |
0.359 | 0.204 | 1 | 0.353 |
CHAK2 |
0.359 | 0.148 | -1 | 0.607 |
AMPKA1 |
0.359 | 0.074 | -3 | 0.235 |
TSSK2 |
0.359 | 0.078 | -5 | 0.302 |
HGK |
0.359 | 0.133 | 3 | 0.441 |
GAK |
0.359 | 0.173 | 1 | 0.412 |
NEK3 |
0.359 | 0.137 | 1 | 0.237 |
MINK |
0.358 | 0.149 | 1 | 0.338 |
PINK1 |
0.357 | 0.123 | 1 | 0.255 |
AMPKA2 |
0.357 | 0.056 | -3 | 0.214 |
NEK1 |
0.357 | 0.134 | 1 | 0.262 |
GCK |
0.357 | 0.143 | 1 | 0.327 |
NEK6 |
0.356 | 0.067 | -2 | 0.243 |
LOK |
0.356 | 0.107 | -2 | 0.227 |
MARK4 |
0.355 | 0.071 | 4 | 0.448 |
PKR |
0.355 | 0.116 | 1 | 0.234 |
SRPK1 |
0.354 | 0.040 | -3 | 0.190 |
P38A |
0.354 | 0.044 | 1 | 0.201 |
JNK2 |
0.354 | 0.028 | 1 | 0.159 |
PIM1 |
0.354 | 0.049 | -3 | 0.178 |
MYO3B |
0.354 | 0.096 | 2 | 0.382 |
HIPK2 |
0.354 | 0.037 | 1 | 0.124 |
QSK |
0.354 | 0.051 | 4 | 0.456 |
HPK1 |
0.354 | 0.136 | 1 | 0.349 |
NEK9 |
0.353 | 0.106 | 2 | 0.371 |
IRAK4 |
0.353 | 0.134 | 1 | 0.229 |
HIPK1 |
0.353 | 0.043 | 1 | 0.165 |
WNK1 |
0.353 | 0.095 | -2 | 0.258 |
MNK2 |
0.352 | 0.077 | -2 | 0.202 |
PIM3 |
0.352 | 0.045 | -3 | 0.222 |
CDK9 |
0.352 | 0.047 | 1 | 0.180 |
HIPK4 |
0.351 | 0.056 | 1 | 0.153 |
PRKD3 |
0.351 | 0.036 | -3 | 0.170 |
RAF1 |
0.350 | 0.121 | 1 | 0.297 |
BUB1 |
0.350 | 0.065 | -5 | 0.217 |
MAPKAPK3 |
0.350 | 0.029 | -3 | 0.213 |
DSTYK |
0.350 | 0.042 | 2 | 0.424 |
CHK1 |
0.350 | 0.021 | -3 | 0.220 |
MST4 |
0.350 | 0.059 | 2 | 0.411 |
WNK4 |
0.349 | 0.096 | -2 | 0.266 |
AURB |
0.349 | 0.046 | -2 | 0.111 |
DCAMKL1 |
0.349 | 0.043 | -3 | 0.205 |
MARK3 |
0.349 | 0.047 | 4 | 0.422 |
CLK1 |
0.349 | 0.048 | -3 | 0.162 |
PAK6 |
0.349 | 0.054 | -2 | 0.172 |
LRRK2 |
0.349 | 0.088 | 2 | 0.372 |
MST1 |
0.349 | 0.080 | 1 | 0.307 |
DNAPK |
0.348 | 0.059 | 1 | 0.265 |
IKKA |
0.348 | 0.051 | -2 | 0.226 |
IKKB |
0.348 | 0.057 | -2 | 0.233 |
CDK18 |
0.348 | 0.035 | 1 | 0.167 |
P38G |
0.348 | 0.018 | 1 | 0.124 |
DYRK2 |
0.347 | 0.027 | 1 | 0.136 |
NIK |
0.347 | 0.043 | -3 | 0.242 |
MEKK1 |
0.347 | 0.078 | 1 | 0.240 |
PKCZ |
0.347 | 0.067 | 2 | 0.314 |
CLK3 |
0.347 | 0.021 | 1 | 0.172 |
MAK |
0.347 | 0.020 | -2 | 0.180 |
ERK1 |
0.347 | 0.021 | 1 | 0.181 |
YSK1 |
0.346 | 0.054 | 2 | 0.356 |
NLK |
0.346 | 0.042 | 1 | 0.222 |
CDK16 |
0.346 | 0.025 | 1 | 0.148 |
ULK2 |
0.346 | 0.037 | 2 | 0.320 |
BRSK1 |
0.345 | 0.027 | -3 | 0.204 |
MOK |
0.345 | 0.018 | 1 | 0.176 |
ROCK2 |
0.345 | 0.037 | -3 | 0.205 |
CDK7 |
0.345 | 0.027 | 1 | 0.172 |
NUAK2 |
0.345 | 0.007 | -3 | 0.207 |
TAO1 |
0.345 | 0.062 | 1 | 0.246 |
LATS2 |
0.345 | 0.011 | -5 | 0.293 |
CDK12 |
0.345 | 0.040 | 1 | 0.155 |
HIPK3 |
0.345 | 0.030 | 1 | 0.183 |
PIM2 |
0.345 | 0.024 | -3 | 0.165 |
MLK2 |
0.345 | 0.041 | 2 | 0.369 |
MELK |
0.345 | 0.021 | -3 | 0.221 |
MARK2 |
0.344 | 0.033 | 4 | 0.395 |
CDK19 |
0.344 | 0.014 | 1 | 0.157 |
MST3 |
0.344 | 0.045 | 2 | 0.372 |
TAO3 |
0.344 | 0.033 | 1 | 0.239 |
MARK1 |
0.344 | 0.027 | 4 | 0.450 |
PDHK1 |
0.344 | 0.077 | 1 | 0.295 |
MEKK6 |
0.344 | 0.060 | 1 | 0.233 |
CDK13 |
0.343 | 0.025 | 1 | 0.170 |
P38D |
0.343 | 0.014 | 1 | 0.162 |
TAO2 |
0.343 | 0.034 | 2 | 0.374 |
MAPKAPK2 |
0.343 | -0.001 | -3 | 0.171 |
CDKL5 |
0.342 | 0.004 | -3 | 0.203 |
MTOR |
0.342 | 0.022 | 1 | 0.232 |
PRKX |
0.342 | 0.014 | -3 | 0.140 |
CDK6 |
0.342 | 0.026 | 1 | 0.209 |
QIK |
0.342 | 0.019 | -3 | 0.217 |
SRPK2 |
0.342 | 0.009 | -3 | 0.144 |
NUAK1 |
0.342 | 0.007 | -3 | 0.175 |
ERK5 |
0.342 | 0.023 | 1 | 0.238 |
YSK4 |
0.342 | 0.036 | 1 | 0.279 |
JNK3 |
0.341 | -0.000 | 1 | 0.149 |
LATS1 |
0.341 | -0.000 | -3 | 0.230 |
MAP3K15 |
0.341 | 0.050 | 1 | 0.211 |
DYRK1A |
0.341 | 0.013 | 1 | 0.159 |
CDC7 |
0.341 | 0.009 | 1 | 0.142 |
PKACB |
0.341 | 0.005 | -2 | 0.131 |
NIM1 |
0.341 | 0.025 | 3 | 0.411 |
IRE1 |
0.341 | 0.045 | 1 | 0.210 |
P38B |
0.341 | 0.002 | 1 | 0.162 |
COT |
0.341 | -0.012 | 2 | 0.380 |
CDK8 |
0.341 | 0.004 | 1 | 0.153 |
CDK4 |
0.341 | 0.015 | 1 | 0.158 |
MEKK2 |
0.341 | 0.017 | 2 | 0.332 |
NEK11 |
0.341 | 0.058 | 1 | 0.251 |
CDK5 |
0.340 | 0.010 | 1 | 0.183 |
CLK2 |
0.340 | 0.010 | -3 | 0.187 |
DYRK3 |
0.340 | 0.013 | 1 | 0.151 |
SGK3 |
0.340 | 0.014 | -3 | 0.195 |
ICK |
0.340 | -0.012 | -3 | 0.219 |
ASK1 |
0.340 | 0.030 | 1 | 0.200 |
PAK5 |
0.340 | 0.026 | -2 | 0.130 |
BMPR2 |
0.340 | -0.054 | -2 | 0.222 |
FAM20C |
0.340 | 0.076 | 2 | 0.471 |
NEK7 |
0.340 | -0.022 | -3 | 0.229 |
BRSK2 |
0.340 | 0.013 | -3 | 0.223 |
MST2 |
0.339 | 0.014 | 1 | 0.298 |
BCKDK |
0.339 | 0.055 | -1 | 0.345 |
SLK |
0.339 | 0.033 | -2 | 0.170 |
NDR1 |
0.339 | -0.009 | -3 | 0.215 |
CLK4 |
0.339 | 0.009 | -3 | 0.175 |
PDHK4 |
0.339 | 0.022 | 1 | 0.254 |
ROCK1 |
0.339 | 0.017 | -3 | 0.184 |
CDKL1 |
0.339 | -0.017 | -3 | 0.194 |
SIK |
0.339 | -0.002 | -3 | 0.165 |
PAK1 |
0.339 | 0.008 | -2 | 0.181 |
MRCKB |
0.339 | 0.014 | -3 | 0.163 |
PKCB |
0.339 | 0.017 | 2 | 0.267 |
CDK10 |
0.339 | 0.023 | 1 | 0.193 |
SKMLCK |
0.339 | 0.006 | -2 | 0.249 |
ULK1 |
0.338 | 0.005 | -3 | 0.235 |
CAMK1B |
0.338 | -0.031 | -3 | 0.213 |
PRPK |
0.338 | -0.045 | -1 | 0.402 |
CAMK2D |
0.338 | 0.003 | -3 | 0.245 |
PKCD |
0.338 | 0.000 | 2 | 0.295 |
CAMK1D |
0.338 | -0.008 | -3 | 0.143 |
MYO3A |
0.338 | 0.031 | 1 | 0.283 |
PDK1 |
0.338 | 0.010 | 1 | 0.220 |
PKCA |
0.337 | 0.029 | 2 | 0.261 |
PAK3 |
0.337 | 0.007 | -2 | 0.202 |
PKN3 |
0.337 | -0.028 | -3 | 0.229 |
DAPK2 |
0.337 | -0.020 | -3 | 0.236 |
PKACG |
0.337 | 0.001 | -2 | 0.154 |
MNK1 |
0.337 | 0.033 | -2 | 0.192 |
AKT2 |
0.336 | -0.013 | -3 | 0.140 |
DMPK1 |
0.336 | 0.003 | -3 | 0.157 |
AKT1 |
0.336 | -0.008 | -3 | 0.159 |
CDK14 |
0.336 | 0.012 | 1 | 0.203 |
SRPK3 |
0.336 | -0.003 | -3 | 0.156 |
HRI |
0.336 | -0.020 | -2 | 0.223 |
WNK3 |
0.336 | 0.005 | 1 | 0.257 |
SBK |
0.336 | -0.006 | -3 | 0.096 |
MOS |
0.335 | -0.039 | 1 | 0.186 |
VRK2 |
0.335 | -0.032 | 1 | 0.209 |
PKG2 |
0.335 | -0.003 | -2 | 0.124 |
NDR2 |
0.335 | -0.032 | -3 | 0.220 |
NEK8 |
0.335 | -0.024 | 2 | 0.327 |
IRAK1 |
0.335 | 0.041 | -1 | 0.404 |
PHKG2 |
0.335 | 0.023 | -3 | 0.194 |
PHKG1 |
0.334 | 0.005 | -3 | 0.230 |
CAMLCK |
0.334 | -0.041 | -2 | 0.226 |
CDK17 |
0.334 | -0.002 | 1 | 0.132 |
RSK3 |
0.334 | -0.020 | -3 | 0.192 |
BMPR1B |
0.334 | -0.042 | 1 | 0.120 |
PKCI |
0.333 | 0.024 | 2 | 0.272 |
PKCG |
0.333 | 0.020 | 2 | 0.251 |
MEK5 |
0.333 | -0.043 | 2 | 0.360 |
SMG1 |
0.333 | -0.004 | 1 | 0.181 |
MRCKA |
0.333 | -0.001 | -3 | 0.165 |
PKN2 |
0.333 | -0.019 | -3 | 0.223 |
TAK1 |
0.333 | -0.019 | 1 | 0.262 |
PKACA |
0.333 | -0.011 | -2 | 0.116 |
CDK3 |
0.333 | -0.002 | 1 | 0.141 |
ERK2 |
0.333 | -0.011 | 1 | 0.164 |
PAK4 |
0.332 | 0.023 | -2 | 0.125 |
DYRK4 |
0.332 | -0.002 | 1 | 0.123 |
CRIK |
0.332 | -0.005 | -3 | 0.147 |
CDK1 |
0.332 | -0.016 | 1 | 0.130 |
BRAF |
0.332 | -0.060 | -4 | 0.476 |
AKT3 |
0.332 | -0.014 | -3 | 0.130 |
ALK2 |
0.331 | -0.042 | -2 | 0.195 |
MEK2 |
0.331 | -0.017 | 2 | 0.371 |
PERK |
0.331 | -0.048 | -2 | 0.215 |
MASTL |
0.331 | -0.040 | -2 | 0.228 |
CHK2 |
0.331 | -0.005 | -3 | 0.127 |
ANKRD3 |
0.331 | -0.042 | 1 | 0.249 |
PKCT |
0.331 | 0.001 | 2 | 0.251 |
ATR |
0.331 | -0.058 | 1 | 0.177 |
CAMK1A |
0.331 | -0.009 | -3 | 0.119 |
EEF2K |
0.331 | -0.034 | 3 | 0.459 |
P70S6KB |
0.331 | -0.037 | -3 | 0.189 |
RIPK1 |
0.330 | -0.010 | 1 | 0.196 |
MAPKAPK5 |
0.330 | -0.011 | -3 | 0.196 |
SGK1 |
0.330 | -0.017 | -3 | 0.116 |
MLK3 |
0.330 | -0.021 | 2 | 0.275 |
DLK |
0.330 | -0.087 | 1 | 0.173 |
DCAMKL2 |
0.329 | -0.008 | -3 | 0.199 |
PAK2 |
0.329 | -0.025 | -2 | 0.171 |
P90RSK |
0.329 | -0.036 | -3 | 0.208 |
AURA |
0.329 | -0.017 | -2 | 0.087 |
ALK4 |
0.328 | -0.065 | -2 | 0.181 |
DAPK3 |
0.328 | -0.033 | -3 | 0.195 |
TTK |
0.328 | -0.042 | -2 | 0.163 |
RIPK3 |
0.328 | -0.011 | 3 | 0.305 |
PLK1 |
0.328 | -0.048 | -2 | 0.163 |
CAMK2A |
0.328 | -0.030 | 2 | 0.396 |
TLK2 |
0.328 | -0.033 | 1 | 0.200 |
CAMK1G |
0.327 | -0.022 | -3 | 0.168 |
MLK1 |
0.327 | -0.076 | 2 | 0.321 |
TLK1 |
0.327 | -0.033 | -2 | 0.217 |
TTBK2 |
0.327 | -0.025 | 2 | 0.302 |
RSK2 |
0.327 | -0.044 | -3 | 0.184 |
STLK3 |
0.327 | -0.052 | 1 | 0.202 |
MEK1 |
0.326 | -0.106 | 2 | 0.388 |
PLK4 |
0.326 | 0.006 | 2 | 0.196 |
TGFBR2 |
0.326 | -0.062 | -2 | 0.158 |
ERK7 |
0.326 | -0.007 | 2 | 0.166 |
PLK3 |
0.325 | -0.044 | 2 | 0.344 |
PKCH |
0.325 | -0.027 | 2 | 0.238 |
ZAK |
0.325 | -0.073 | 1 | 0.186 |
TGFBR1 |
0.325 | -0.060 | -2 | 0.183 |
CAMK2G |
0.325 | -0.073 | 2 | 0.384 |
PKCE |
0.325 | -0.005 | 2 | 0.250 |
VRK1 |
0.325 | -0.073 | 2 | 0.321 |
PKG1 |
0.324 | -0.010 | -2 | 0.094 |
MSK2 |
0.324 | -0.045 | -3 | 0.175 |
OSR1 |
0.324 | -0.069 | 2 | 0.350 |
IRE2 |
0.324 | -0.042 | 2 | 0.243 |
MSK1 |
0.324 | -0.033 | -3 | 0.182 |
CAMK2B |
0.323 | -0.042 | 2 | 0.412 |
STK33 |
0.323 | 0.004 | 2 | 0.218 |
CDK2 |
0.322 | -0.030 | 1 | 0.153 |
ATM |
0.322 | -0.047 | 1 | 0.141 |
GCN2 |
0.322 | -0.104 | 2 | 0.336 |
MEKK3 |
0.322 | -0.079 | 1 | 0.226 |
SMMLCK |
0.322 | -0.062 | -3 | 0.200 |
RSK4 |
0.321 | -0.046 | -3 | 0.166 |
PKN1 |
0.321 | -0.032 | -3 | 0.170 |
CAMK4 |
0.320 | -0.083 | -3 | 0.196 |
GRK5 |
0.319 | -0.127 | -3 | 0.224 |
SNRK |
0.318 | -0.054 | 2 | 0.220 |
MYLK4 |
0.318 | -0.058 | -2 | 0.204 |
JNK1 |
0.318 | -0.032 | 1 | 0.141 |
GRK6 |
0.317 | -0.098 | 1 | 0.165 |
DAPK1 |
0.317 | -0.053 | -3 | 0.186 |
GRK7 |
0.316 | -0.066 | 1 | 0.152 |
P70S6K |
0.315 | -0.052 | -3 | 0.150 |
GSK3A |
0.315 | -0.010 | 4 | 0.126 |
MLK4 |
0.314 | -0.088 | 2 | 0.249 |
PASK |
0.314 | -0.097 | -3 | 0.218 |
BMPR1A |
0.313 | -0.088 | 1 | 0.102 |
GRK1 |
0.312 | -0.074 | -2 | 0.147 |
ACVR2A |
0.310 | -0.124 | -2 | 0.158 |
ACVR2B |
0.309 | -0.126 | -2 | 0.175 |
CK2A2 |
0.309 | -0.026 | 1 | 0.098 |
DRAK1 |
0.308 | -0.112 | 1 | 0.121 |
TTBK1 |
0.307 | -0.055 | 2 | 0.239 |
CK1E |
0.305 | -0.061 | -3 | 0.086 |
KIS |
0.305 | -0.063 | 1 | 0.167 |
GSK3B |
0.305 | -0.038 | 4 | 0.124 |
PLK2 |
0.304 | -0.062 | -3 | 0.180 |
RIPK2 |
0.303 | -0.099 | 1 | 0.207 |
GRK4 |
0.303 | -0.160 | -2 | 0.175 |
CK2A1 |
0.303 | -0.038 | 1 | 0.085 |
GRK2 |
0.302 | -0.117 | -2 | 0.146 |
ALPHAK3 |
0.301 | -0.125 | -1 | 0.384 |
CK1G1 |
0.299 | -0.045 | -3 | 0.073 |
CK1D |
0.298 | -0.073 | -3 | 0.069 |
CK1A2 |
0.293 | -0.075 | -3 | 0.062 |
GRK3 |
0.287 | -0.126 | -2 | 0.119 |
YANK3 |
0.283 | -0.056 | 2 | 0.138 |
CK1G3 |
0.276 | -0.065 | -3 | 0.020 |
YANK2 |
0.273 | -0.066 | 2 | 0.145 |
CK1A |
0.266 | -0.092 | -3 | 0.038 |
CK1G2 |
0.238 | -0.112 | -3 | 0.047 |