Motif 1113 (n=65)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O15391 | YY2 | T306 | ochoa | Transcription factor YY2 (Yin and yang 2) (YY-2) (Zinc finger protein 631) | Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation. {ECO:0000269|PubMed:16260628}. |
| O43474 | KLF4 | T485 | ochoa | Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor) | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}. |
| O43623 | SNAI2 | T208 | psp | Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) | Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. {ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}. |
| O43623 | SNAI2 | S236 | ochoa | Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) | Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. {ECO:0000250, ECO:0000269|PubMed:10866665, ECO:0000269|PubMed:11912130, ECO:0000269|PubMed:15734731, ECO:0000269|PubMed:16707493, ECO:0000269|PubMed:19756381, ECO:0000269|PubMed:21182836}. |
| O43829 | ZBTB14 | T300 | ochoa | Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) | Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}. |
| O43829 | ZBTB14 | S356 | ochoa | Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) | Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters. {ECO:0000269|PubMed:17714511}. |
| O60315 | ZEB2 | S1050 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
| O95125 | ZNF202 | S476 | ochoa | Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10) | Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease. |
| O95365 | ZBTB7A | T461 | ochoa | Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A) | Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149). {ECO:0000250|UniProtKB:O88939, ECO:0000250|UniProtKB:Q9QZ48, ECO:0000269|PubMed:12004059, ECO:0000269|PubMed:14701838, ECO:0000269|PubMed:17595526, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:24514149, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:26455326, ECO:0000269|PubMed:26816381}. |
| O95625 | ZBTB11 | S817 | ochoa | Zinc finger and BTB domain-containing protein 11 | May be involved in transcriptional regulation. {ECO:0000305}. |
| O95863 | SNAI1 | T203 | psp | Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949). {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:25827072}. |
| O95863 | SNAI1 | S231 | ochoa | Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna) | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949). {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:23721412, ECO:0000269|PubMed:25827072}. |
| P08047 | SP1 | T681 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P10074 | ZBTB48 | T516 | ochoa | Zinc finger and BTB domain-containing protein 48 (Krueppel-related zinc finger protein 3) (hKR3) (Telomere zinc finger-associated protein) (TZAP) (Telomere-binding protein and transcriptional activator ZBTB48) (Zinc finger protein 855) | Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length (PubMed:28082411, PubMed:28500257). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28082411, PubMed:28500257). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:24382891, PubMed:28500257, PubMed:7969177). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression (PubMed:39562739). In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs (PubMed:39300486). {ECO:0000269|PubMed:24382891, ECO:0000269|PubMed:28082411, ECO:0000269|PubMed:28500257, ECO:0000269|PubMed:39300486, ECO:0000269|PubMed:39562739, ECO:0000269|PubMed:7969177}. |
| P25490 | YY1 | T348 | ochoa|psp | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
| P25490 | YY1 | T378 | ochoa|psp | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression (PubMed:15329343, PubMed:17721549, PubMed:24326773, PubMed:25787250). For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence (PubMed:1655281). Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed (PubMed:11158321). Involved in DNA repair (PubMed:18026119, PubMed:28575647). In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation (PubMed:28575647). Recruits the PR-DUB complex to specific gene-regulatory regions (PubMed:20805357). {ECO:0000269|PubMed:11158321, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:1655281, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:20805357, ECO:0000269|PubMed:24326773, ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}.; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:18026119}. |
| P37275 | ZEB1 | S955 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P49711 | CTCF | T317 | ochoa | Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) | Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin (PubMed:18347100, PubMed:18654629, PubMed:19322193). Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina (PubMed:18347100, PubMed:18654629, PubMed:19322193). Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers (PubMed:18347100, PubMed:18654629, PubMed:19322193). Plays a critical role in the epigenetic regulation (PubMed:16949368). Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (PubMed:16107875, PubMed:16815976, PubMed:17827499). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (By similarity). Regulates asynchronous replication of IGF2/H19 (By similarity). Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones (PubMed:18413740). Inversely, binding to target sites is prevented by CpG methylation (PubMed:18413740). Plays an important role in chromatin remodeling (PubMed:18413740). Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (PubMed:12191639). Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription (PubMed:12191639). When bound to chromatin, it provides an anchor point for nucleosomes positioning (PubMed:12191639). Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation (PubMed:11743158). May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation (PubMed:11743158). Involved in sister chromatid cohesion (PubMed:12191639). Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites (PubMed:18550811). Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene (PubMed:18413740, PubMed:8649389, PubMed:9591631). Also binds to the PLK and PIM1 promoters (PubMed:12191639). Acts as a transcriptional activator of APP (PubMed:9407128). Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (PubMed:18347100, PubMed:19322193). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor (PubMed:12191639). {ECO:0000250|UniProtKB:Q61164, ECO:0000269|PubMed:11743158, ECO:0000269|PubMed:16107875, ECO:0000269|PubMed:16815976, ECO:0000269|PubMed:16949368, ECO:0000269|PubMed:17827499, ECO:0000269|PubMed:18347100, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18550811, ECO:0000269|PubMed:18654629, ECO:0000269|PubMed:19322193, ECO:0000269|PubMed:26321640, ECO:0000269|PubMed:8649389, ECO:0000269|PubMed:9407128, ECO:0000269|PubMed:9591631, ECO:0000303|PubMed:12191639}. |
| P49711 | CTCF | T374 | ochoa | Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) | Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin (PubMed:18347100, PubMed:18654629, PubMed:19322193). Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina (PubMed:18347100, PubMed:18654629, PubMed:19322193). Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers (PubMed:18347100, PubMed:18654629, PubMed:19322193). Plays a critical role in the epigenetic regulation (PubMed:16949368). Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (PubMed:16107875, PubMed:16815976, PubMed:17827499). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (By similarity). Regulates asynchronous replication of IGF2/H19 (By similarity). Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones (PubMed:18413740). Inversely, binding to target sites is prevented by CpG methylation (PubMed:18413740). Plays an important role in chromatin remodeling (PubMed:18413740). Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (PubMed:12191639). Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription (PubMed:12191639). When bound to chromatin, it provides an anchor point for nucleosomes positioning (PubMed:12191639). Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation (PubMed:11743158). May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation (PubMed:11743158). Involved in sister chromatid cohesion (PubMed:12191639). Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites (PubMed:18550811). Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene (PubMed:18413740, PubMed:8649389, PubMed:9591631). Also binds to the PLK and PIM1 promoters (PubMed:12191639). Acts as a transcriptional activator of APP (PubMed:9407128). Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (PubMed:18347100, PubMed:19322193). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor (PubMed:12191639). {ECO:0000250|UniProtKB:Q61164, ECO:0000269|PubMed:11743158, ECO:0000269|PubMed:16107875, ECO:0000269|PubMed:16815976, ECO:0000269|PubMed:16949368, ECO:0000269|PubMed:17827499, ECO:0000269|PubMed:18347100, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18550811, ECO:0000269|PubMed:18654629, ECO:0000269|PubMed:19322193, ECO:0000269|PubMed:26321640, ECO:0000269|PubMed:8649389, ECO:0000269|PubMed:9407128, ECO:0000269|PubMed:9591631, ECO:0000303|PubMed:12191639}. |
| P49711 | CTCF | S402 | ochoa | Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) | Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin (PubMed:18347100, PubMed:18654629, PubMed:19322193). Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina (PubMed:18347100, PubMed:18654629, PubMed:19322193). Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers (PubMed:18347100, PubMed:18654629, PubMed:19322193). Plays a critical role in the epigenetic regulation (PubMed:16949368). Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (PubMed:16107875, PubMed:16815976, PubMed:17827499). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (By similarity). Regulates asynchronous replication of IGF2/H19 (By similarity). Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones (PubMed:18413740). Inversely, binding to target sites is prevented by CpG methylation (PubMed:18413740). Plays an important role in chromatin remodeling (PubMed:18413740). Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (PubMed:12191639). Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription (PubMed:12191639). When bound to chromatin, it provides an anchor point for nucleosomes positioning (PubMed:12191639). Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation (PubMed:11743158). May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation (PubMed:11743158). Involved in sister chromatid cohesion (PubMed:12191639). Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites (PubMed:18550811). Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene (PubMed:18413740, PubMed:8649389, PubMed:9591631). Also binds to the PLK and PIM1 promoters (PubMed:12191639). Acts as a transcriptional activator of APP (PubMed:9407128). Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (PubMed:18347100, PubMed:19322193). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor (PubMed:12191639). {ECO:0000250|UniProtKB:Q61164, ECO:0000269|PubMed:11743158, ECO:0000269|PubMed:16107875, ECO:0000269|PubMed:16815976, ECO:0000269|PubMed:16949368, ECO:0000269|PubMed:17827499, ECO:0000269|PubMed:18347100, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18550811, ECO:0000269|PubMed:18654629, ECO:0000269|PubMed:19322193, ECO:0000269|PubMed:26321640, ECO:0000269|PubMed:8649389, ECO:0000269|PubMed:9407128, ECO:0000269|PubMed:9591631, ECO:0000303|PubMed:12191639}. |
| P52747 | ZNF143 | T262 | ochoa | Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf) | Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed:26416877). {ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:26416877, ECO:0000269|PubMed:9776743}. |
| P52747 | ZNF143 | T352 | ochoa | Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf) | Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed:26416877). {ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:26416877, ECO:0000269|PubMed:9776743}. |
| P56270 | MAZ | S302 | ochoa | Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Serum amyloid A-activating factor-1) (SAF-1) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801) | Transcriptional regulator, potentially with dual roles in transcription initiation and termination. {ECO:0000303|PubMed:1502157}.; FUNCTION: [Isoform 1]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157). {ECO:0000269|PubMed:12270922, ECO:0000269|PubMed:1502157}.; FUNCTION: [Isoform 2]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922). {ECO:0000269|PubMed:12270922}.; FUNCTION: [Isoform 3]: Binds DNA and functions as a transcriptional activator. {ECO:0000269|PubMed:19583771}. |
| P56270 | MAZ | S361 | ochoa | Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Serum amyloid A-activating factor-1) (SAF-1) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801) | Transcriptional regulator, potentially with dual roles in transcription initiation and termination. {ECO:0000303|PubMed:1502157}.; FUNCTION: [Isoform 1]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157). Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157). {ECO:0000269|PubMed:12270922, ECO:0000269|PubMed:1502157}.; FUNCTION: [Isoform 2]: Binds DNA and functions as a transcriptional activator (PubMed:12270922). Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922). {ECO:0000269|PubMed:12270922}.; FUNCTION: [Isoform 3]: Binds DNA and functions as a transcriptional activator. {ECO:0000269|PubMed:19583771}. |
| Q02447 | SP3 | S646 | psp | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q13422 | IKZF1 | T140 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q14119 | VEZF1 | S197 | ochoa | Vascular endothelial zinc finger 1 (Putative transcription factor DB1) (Zinc finger protein 161) | Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. {ECO:0000269|PubMed:36657711, ECO:0000269|PubMed:8035792}. |
| Q14872 | MTF1 | T254 | psp | Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) | Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). {ECO:0000250|UniProtKB:Q07243, ECO:0000269|PubMed:8065932}. |
| Q14872 | MTF1 | T284 | ochoa | Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) | Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). {ECO:0000250|UniProtKB:Q07243, ECO:0000269|PubMed:8065932}. |
| Q5SVQ8 | ZBTB41 | S691 | ochoa | Zinc finger and BTB domain-containing protein 41 | May be involved in transcriptional regulation. |
| Q5T0B9 | ZNF362 | T306 | ochoa | Zinc finger protein 362 | May be involved in transcriptional regulation. |
| Q66K89 | E4F1 | T458 | ochoa | Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F) | May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes. |
| Q6DD87 | ZNF787 | S173 | ochoa | Zinc finger protein 787 (TTF-I-interacting peptide 20) | May be involved in transcriptional regulation. |
| Q6ZN55 | ZNF574 | T387 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZN55 | ZNF574 | T518 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q6ZN55 | ZNF574 | T789 | ochoa | Zinc finger protein 574 | May be involved in transcriptional regulation. |
| Q8N0Y2 | ZNF444 | S273 | ochoa | Zinc finger protein 444 (Endothelial zinc finger protein 2) (EZF-2) (Zinc finger and SCAN domain-containing protein 17) | Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. |
| Q8NDX6 | ZNF740 | S152 | ochoa | Zinc finger protein 740 (OriLyt TD-element-binding protein 7) | May be involved in transcriptional regulation. |
| Q8TF68 | ZNF384 | T368 | ochoa | Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein) | Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}. |
| Q8WUU4 | ZNF296 | T254 | ochoa | Zinc finger protein 296 (ZFP296) (Zinc finger protein 342) | May be a transcriptional corepressor with KLF4. {ECO:0000250|UniProtKB:E9Q6W4}. |
| Q92618 | ZNF516 | S1121 | ochoa | Zinc finger protein 516 | Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). {ECO:0000250|UniProtKB:Q7TSH3, ECO:0000269|PubMed:23446422}. |
| Q92664 | GTF3A | T65 | ochoa | Transcription factor IIIA (TFIIIA) | Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity). {ECO:0000250|UniProtKB:P17842, ECO:0000269|PubMed:24120868}. |
| Q92766 | RREB1 | S231 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q96DT7 | ZBTB10 | T745 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96K58 | ZNF668 | T163 | ochoa | Zinc finger protein 668 | May be involved in transcriptional regulation. May play a role in DNA repair process. {ECO:0000269|PubMed:34313816}. |
| Q9BWE0 | REPIN1 | S426 | ochoa | DNA-binding protein REPIN1 (60 kDa origin-specific DNA-binding protein) (60 kDa replication initiation region protein) (ATT-binding protein) (DHFR oribeta-binding protein RIP60) (Zinc finger protein 464) | Sequence-specific double-stranded DNA-binding protein (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (PubMed:10606657, PubMed:11328883, PubMed:2174103, PubMed:2247056, PubMed:8355269). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity). {ECO:0000250|UniProtKB:Q5U4E2, ECO:0000269|PubMed:10606657, ECO:0000269|PubMed:11328883, ECO:0000269|PubMed:2174103, ECO:0000269|PubMed:2247056, ECO:0000269|PubMed:8355269}. |
| Q9BXK1 | KLF16 | T152 | ochoa | Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2) | Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity). {ECO:0000250}. |
| Q9H116 | GZF1 | T542 | ochoa | GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) | Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. {ECO:0000269|PubMed:14522971, ECO:0000269|PubMed:16049025}. |
| Q9H9D4 | ZNF408 | S432 | ochoa | Zinc finger protein 408 (PR domain zinc finger protein 17) | May be involved in transcriptional regulation. |
| Q9NTW7 | ZFP64 | S226 | psp | Zinc finger protein 64 (Zfp-64) (Zinc finger protein 338) | May be involved in the regulation of mesenchymal cell differentiation through transactivation of NOTCH1 target genes. {ECO:0000250|UniProtKB:Q99KE8}. |
| Q9P0T4 | ZNF581 | S110 | ochoa | Zinc finger protein 581 | May be involved in transcriptional regulation. |
| Q9UDV7 | ZNF282 | T597 | ochoa | Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) | Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression. |
| Q9UDV7 | ZNF282 | S653 | ochoa | Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) | Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression. |
| Q9UFB7 | ZBTB47 | S571 | ochoa | Zinc finger and BTB domain-containing protein 47 (Zinc finger protein 651) | May be involved in transcriptional regulation. |
| Q9UKT9 | IKZF3 | T141 | ochoa | Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:34155405}. |
| Q9UQR1 | ZNF148 | T194 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9UQR1 | ZNF148 | S250 | ochoa | Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) | Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. |
| Q9Y2D9 | ZNF652 | S380 | ochoa | Zinc finger protein 652 | Functions as a transcriptional repressor. {ECO:0000269|PubMed:16966434}. |
| Q9Y2K1 | ZBTB1 | T601 | ochoa | Zinc finger and BTB domain-containing protein 1 | Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity). {ECO:0000250|UniProtKB:Q91VL9, ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167, ECO:0000269|PubMed:24657165}. |
| Q9Y2X9 | ZNF281 | S340 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y2Y9 | KLF13 | T192 | ochoa | Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Novel Sp1-like zinc finger transcription factor 1) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) (Transcription factor NSLP1) | Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage (By similarity). Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1 (PubMed:11477107). Activates RANTES and CCL5 expression in T-cells (PubMed:17513757). {ECO:0000250|UniProtKB:Q9JJZ6, ECO:0000269|PubMed:11477107, ECO:0000269|PubMed:17513757}. |
| Q9Y5W3 | KLF2 | T297 | psp | Krueppel-like factor 2 (Lung krueppel-like factor) | Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). {ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:28167758}. |
| Q9Y5W3 | KLF2 | T327 | psp | Krueppel-like factor 2 (Lung krueppel-like factor) | Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). {ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:28167758}. |
| P18146 | EGR1 | T391 | SIGNOR|iPTMNet | Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) | Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}. |
| Q96K58 | ZNF668 | T219 | ochoa | Zinc finger protein 668 | May be involved in transcriptional regulation. May play a role in DNA repair process. {ECO:0000269|PubMed:34313816}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.167827e-07 | 6.287 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.739457e-05 | 4.760 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.371761e-05 | 4.863 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 8.287208e-05 | 4.082 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 8.287208e-05 | 4.082 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 1.283890e-04 | 3.891 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.529608e-04 | 3.815 |
| R-HSA-418990 | Adherens junctions interactions | 2.634934e-04 | 3.579 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.202590e-04 | 3.494 |
| R-HSA-9758919 | Epithelial-Mesenchymal Transition (EMT) during gastrulation | 4.285539e-04 | 3.368 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.384311e-04 | 3.358 |
| R-HSA-421270 | Cell-cell junction organization | 5.224559e-04 | 3.282 |
| R-HSA-446728 | Cell junction organization | 8.549567e-04 | 3.068 |
| R-HSA-9832991 | Formation of the posterior neural plate | 1.293725e-03 | 2.888 |
| R-HSA-1500931 | Cell-Cell communication | 1.575587e-03 | 2.803 |
| R-HSA-9823739 | Formation of the anterior neural plate | 2.354513e-03 | 2.628 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.152947e-03 | 2.667 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 3.417438e-03 | 2.466 |
| R-HSA-9758941 | Gastrulation | 3.554092e-03 | 2.449 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 4.664744e-03 | 2.331 |
| R-HSA-9839394 | TGFBR3 expression | 6.090927e-03 | 2.215 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 8.117004e-03 | 2.091 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.123892e-02 | 1.949 |
| R-HSA-74158 | RNA Polymerase III Transcription | 1.138943e-02 | 1.943 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 1.138943e-02 | 1.943 |
| R-HSA-5660489 | MTF1 activates gene expression | 2.211211e-02 | 1.655 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.873087e-02 | 1.727 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.749949e-02 | 1.757 |
| R-HSA-6807070 | PTEN Regulation | 2.065209e-02 | 1.685 |
| R-HSA-73857 | RNA Polymerase II Transcription | 2.291191e-02 | 1.640 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.906127e-02 | 1.537 |
| R-HSA-212436 | Generic Transcription Pathway | 2.946808e-02 | 1.531 |
| R-HSA-74160 | Gene expression (Transcription) | 2.965219e-02 | 1.528 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 4.917696e-02 | 1.308 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 3.612248e-02 | 1.442 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 4.202387e-02 | 1.377 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 4.374325e-02 | 1.359 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.530798e-02 | 1.452 |
| R-HSA-1266738 | Developmental Biology | 5.714490e-02 | 1.243 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 6.140921e-02 | 1.212 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 9.915241e-02 | 1.004 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 9.915241e-02 | 1.004 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 9.965840e-02 | 1.001 |
| R-HSA-1181150 | Signaling by NODAL | 8.900943e-02 | 1.051 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.981386e-02 | 1.156 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.981386e-02 | 1.156 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 6.838539e-02 | 1.165 |
| R-HSA-5660526 | Response to metal ions | 7.531057e-02 | 1.123 |
| R-HSA-422085 | Synthesis, secretion, and deacylation of Ghrelin | 9.240284e-02 | 1.034 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 7.531057e-02 | 1.123 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.256606e-01 | 0.901 |
| R-HSA-909733 | Interferon alpha/beta signaling | 8.377030e-02 | 1.077 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 1.091843e-01 | 0.962 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.114836e-01 | 0.953 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 1.131031e-01 | 0.947 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.366205e-02 | 1.196 |
| R-HSA-166520 | Signaling by NTRKs | 1.273709e-01 | 0.895 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.298618e-01 | 0.887 |
| R-HSA-1989781 | PPARA activates gene expression | 1.361386e-01 | 0.866 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.386255e-01 | 0.858 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 1.386686e-01 | 0.858 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.424831e-01 | 0.846 |
| R-HSA-2559585 | Oncogene Induced Senescence | 1.450369e-01 | 0.839 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.514014e-01 | 0.820 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.525020e-01 | 0.817 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 1.545661e-01 | 0.811 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.763966e-01 | 0.754 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.857387e-01 | 0.731 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.095867e-01 | 0.679 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.125379e-01 | 0.673 |
| R-HSA-8939211 | ESR-mediated signaling | 2.485083e-01 | 0.605 |
| R-HSA-5689603 | UCH proteinases | 2.693380e-01 | 0.570 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 2.909124e-01 | 0.536 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.296893e-01 | 0.482 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.321990e-01 | 0.479 |
| R-HSA-1483255 | PI Metabolism | 3.446093e-01 | 0.463 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.543741e-01 | 0.451 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.567929e-01 | 0.448 |
| R-HSA-8957322 | Metabolism of steroids | 3.677737e-01 | 0.434 |
| R-HSA-2980736 | Peptide hormone metabolism | 3.874373e-01 | 0.412 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 3.965742e-01 | 0.402 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.192311e-01 | 0.378 |
| R-HSA-9843745 | Adipogenesis | 4.231883e-01 | 0.373 |
| R-HSA-913531 | Interferon Signaling | 4.460928e-01 | 0.351 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 4.690163e-01 | 0.329 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.167573e-01 | 0.287 |
| R-HSA-2559583 | Cellular Senescence | 5.257859e-01 | 0.279 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 5.892986e-01 | 0.230 |
| R-HSA-157118 | Signaling by NOTCH | 6.234369e-01 | 0.205 |
| R-HSA-5688426 | Deubiquitination | 6.442418e-01 | 0.191 |
| R-HSA-9711123 | Cellular response to chemical stress | 6.613554e-01 | 0.180 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 6.893357e-01 | 0.162 |
| R-HSA-1483257 | Phospholipid metabolism | 6.943535e-01 | 0.158 |
| R-HSA-449147 | Signaling by Interleukins | 6.993127e-01 | 0.155 |
| R-HSA-73894 | DNA Repair | 7.613743e-01 | 0.118 |
| R-HSA-9679506 | SARS-CoV Infections | 8.875795e-01 | 0.052 |
| R-HSA-162582 | Signal Transduction | 9.031465e-01 | 0.044 |
| R-HSA-556833 | Metabolism of lipids | 9.286900e-01 | 0.032 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.374792e-01 | 0.028 |
| R-HSA-2262752 | Cellular responses to stress | 9.817185e-01 | 0.008 |
| R-HSA-9824446 | Viral Infection Pathways | 9.881756e-01 | 0.005 |
| R-HSA-597592 | Post-translational protein modification | 9.892499e-01 | 0.005 |
| R-HSA-168256 | Immune System | 9.955675e-01 | 0.002 |
| R-HSA-392499 | Metabolism of proteins | 9.963088e-01 | 0.002 |
| R-HSA-5663205 | Infectious disease | 9.988223e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999788e-01 | 0.000 |
| R-HSA-1643685 | Disease | 9.999917e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PIM2 |
0.511 | 0.352 | -3 | 0.814 |
SBK |
0.509 | 0.311 | -3 | 0.893 |
SRPK1 |
0.509 | 0.365 | -3 | 0.802 |
PBK |
0.508 | 0.415 | 1 | 0.734 |
SRPK3 |
0.507 | 0.362 | -3 | 0.794 |
SRPK2 |
0.504 | 0.368 | -3 | 0.845 |
AAK1 |
0.501 | 0.345 | 1 | 0.857 |
PIM1 |
0.498 | 0.359 | -3 | 0.763 |
BIKE |
0.497 | 0.358 | 1 | 0.808 |
AKT3 |
0.495 | 0.302 | -3 | 0.861 |
AKT2 |
0.493 | 0.292 | -3 | 0.849 |
MOK |
0.490 | 0.221 | 1 | 0.360 |
MPSK1 |
0.490 | 0.308 | 1 | 0.576 |
CDKL1 |
0.488 | 0.301 | -3 | 0.757 |
LATS2 |
0.487 | 0.412 | -5 | 0.540 |
CRIK |
0.487 | 0.254 | -3 | 0.833 |
CDKL5 |
0.486 | 0.271 | -3 | 0.772 |
AKT1 |
0.486 | 0.256 | -3 | 0.823 |
CHK2 |
0.486 | 0.272 | -3 | 0.860 |
DMPK1 |
0.485 | 0.232 | -3 | 0.785 |
CLK1 |
0.483 | 0.233 | -3 | 0.810 |
PIM3 |
0.483 | 0.356 | -3 | 0.685 |
MAK |
0.483 | 0.209 | -2 | 0.440 |
CAMK1D |
0.481 | 0.258 | -3 | 0.817 |
LATS1 |
0.481 | 0.339 | -3 | 0.594 |
NDR1 |
0.479 | 0.335 | -3 | 0.672 |
CLK4 |
0.478 | 0.222 | -3 | 0.791 |
PRKD3 |
0.478 | 0.244 | -3 | 0.798 |
P70S6K |
0.478 | 0.247 | -3 | 0.821 |
CLK2 |
0.478 | 0.250 | -3 | 0.800 |
CDK6 |
0.477 | 0.126 | 1 | 0.342 |
SGK1 |
0.477 | 0.255 | -3 | 0.864 |
ICK |
0.475 | 0.231 | -3 | 0.711 |
CAMK1A |
0.475 | 0.233 | -3 | 0.844 |
CDK10 |
0.474 | 0.133 | 1 | 0.334 |
MAPKAPK2 |
0.474 | 0.257 | -3 | 0.783 |
PKN1 |
0.474 | 0.231 | -3 | 0.810 |
CDK4 |
0.473 | 0.102 | 1 | 0.284 |
MRCKB |
0.473 | 0.212 | -3 | 0.790 |
MAPKAPK3 |
0.473 | 0.239 | -3 | 0.732 |
DCAMKL1 |
0.472 | 0.234 | -3 | 0.724 |
GAK |
0.472 | 0.304 | 1 | 0.639 |
CHK1 |
0.471 | 0.166 | -3 | 0.619 |
RSK2 |
0.471 | 0.236 | -3 | 0.800 |
MELK |
0.470 | 0.219 | -3 | 0.714 |
PKN3 |
0.470 | 0.221 | -3 | 0.677 |
CLK3 |
0.470 | 0.196 | 1 | 0.375 |
CAMK1B |
0.470 | 0.210 | -3 | 0.675 |
HIPK1 |
0.470 | 0.143 | 1 | 0.329 |
NIK |
0.469 | 0.237 | -3 | 0.580 |
PASK |
0.469 | 0.237 | -3 | 0.634 |
MRCKA |
0.469 | 0.196 | -3 | 0.767 |
TNIK |
0.468 | 0.202 | 3 | 0.574 |
P70S6KB |
0.467 | 0.206 | -3 | 0.760 |
PKCE |
0.467 | 0.189 | 2 | 0.270 |
NUAK2 |
0.467 | 0.184 | -3 | 0.703 |
PRKD2 |
0.467 | 0.219 | -3 | 0.768 |
ROCK2 |
0.467 | 0.199 | -3 | 0.723 |
P90RSK |
0.467 | 0.241 | -3 | 0.789 |
SMMLCK |
0.466 | 0.175 | -3 | 0.724 |
CAMK2D |
0.466 | 0.199 | -3 | 0.644 |
KHS2 |
0.465 | 0.180 | 1 | 0.258 |
NDR2 |
0.465 | 0.348 | -3 | 0.625 |
HGK |
0.465 | 0.178 | 3 | 0.559 |
AMPKA2 |
0.465 | 0.170 | -3 | 0.697 |
RSK3 |
0.465 | 0.244 | -3 | 0.788 |
DYRK1A |
0.465 | 0.170 | 1 | 0.309 |
BUB1 |
0.464 | 0.063 | -5 | 0.105 |
CAMK1G |
0.464 | 0.202 | -3 | 0.792 |
IRE2 |
0.464 | 0.185 | 2 | 0.323 |
ROCK1 |
0.464 | 0.188 | -3 | 0.765 |
AMPKA1 |
0.463 | 0.148 | -3 | 0.649 |
HIPK3 |
0.463 | 0.130 | 1 | 0.298 |
DCAMKL2 |
0.463 | 0.166 | -3 | 0.726 |
DAPK3 |
0.463 | 0.187 | -3 | 0.740 |
CAMLCK |
0.463 | 0.154 | -2 | 0.538 |
DYRK3 |
0.463 | 0.159 | 1 | 0.313 |
CDK3 |
0.463 | 0.097 | 1 | 0.297 |
CDK2 |
0.462 | 0.101 | 1 | 0.313 |
DAPK2 |
0.462 | 0.166 | -3 | 0.639 |
PKCD |
0.462 | 0.175 | 2 | 0.347 |
IRE1 |
0.461 | 0.169 | 1 | 0.341 |
SGK3 |
0.461 | 0.191 | -3 | 0.747 |
CDK5 |
0.461 | 0.081 | 1 | 0.358 |
WNK1 |
0.461 | 0.114 | -2 | 0.589 |
TSSK2 |
0.460 | 0.070 | -5 | 0.142 |
MAPKAPK5 |
0.460 | 0.236 | -3 | 0.772 |
KHS1 |
0.460 | 0.148 | 1 | 0.258 |
PKN2 |
0.460 | 0.176 | -3 | 0.651 |
IRAK1 |
0.460 | 0.111 | -1 | 0.189 |
PKR |
0.460 | 0.112 | 1 | 0.358 |
NLK |
0.460 | 0.089 | 1 | 0.352 |
IRAK4 |
0.459 | 0.113 | 1 | 0.332 |
RSK4 |
0.459 | 0.212 | -3 | 0.802 |
NUAK1 |
0.459 | 0.170 | -3 | 0.745 |
HASPIN |
0.459 | 0.059 | -1 | 0.119 |
PKCI |
0.459 | 0.143 | 2 | 0.296 |
CAMK2A |
0.458 | 0.172 | 2 | 0.519 |
TAO2 |
0.458 | 0.120 | 2 | 0.392 |
PKACA |
0.458 | 0.194 | -2 | 0.348 |
TSSK1 |
0.456 | 0.092 | -3 | 0.632 |
DAPK1 |
0.456 | 0.165 | -3 | 0.759 |
MYLK4 |
0.456 | 0.157 | -2 | 0.466 |
MST4 |
0.456 | 0.103 | 2 | 0.385 |
WNK4 |
0.456 | 0.087 | -2 | 0.589 |
MSK1 |
0.455 | 0.193 | -3 | 0.776 |
MINK |
0.455 | 0.126 | 1 | 0.279 |
PKCB |
0.455 | 0.167 | 2 | 0.296 |
BRAF |
0.455 | 0.115 | -4 | 0.579 |
DYRK2 |
0.455 | 0.101 | 1 | 0.297 |
CAMK4 |
0.455 | 0.143 | -3 | 0.672 |
LOK |
0.454 | 0.127 | -2 | 0.507 |
HIPK4 |
0.454 | 0.137 | 1 | 0.311 |
DYRK1B |
0.454 | 0.104 | 1 | 0.317 |
MSK2 |
0.454 | 0.213 | -3 | 0.779 |
PKACB |
0.454 | 0.187 | -2 | 0.375 |
SKMLCK |
0.454 | 0.164 | -2 | 0.513 |
PKG2 |
0.454 | 0.145 | -2 | 0.404 |
PKCT |
0.453 | 0.161 | 2 | 0.297 |
PINK1 |
0.453 | 0.097 | 1 | 0.441 |
CDK14 |
0.453 | 0.059 | 1 | 0.335 |
CAMK2B |
0.453 | 0.156 | 2 | 0.582 |
HPK1 |
0.453 | 0.120 | 1 | 0.250 |
RIPK1 |
0.453 | 0.122 | 1 | 0.298 |
EEF2K |
0.453 | 0.122 | 3 | 0.625 |
PRKD1 |
0.452 | 0.149 | -3 | 0.673 |
PRKX |
0.452 | 0.207 | -3 | 0.787 |
LRRK2 |
0.452 | 0.117 | 2 | 0.383 |
PHKG2 |
0.452 | 0.153 | -3 | 0.709 |
PKCA |
0.452 | 0.128 | 2 | 0.288 |
PKCZ |
0.451 | 0.136 | 2 | 0.323 |
PDK1 |
0.451 | 0.104 | 1 | 0.290 |
MEKK6 |
0.450 | 0.056 | 1 | 0.296 |
CDK13 |
0.450 | 0.057 | 1 | 0.313 |
CDK9 |
0.450 | 0.049 | 1 | 0.314 |
HRI |
0.450 | 0.078 | -2 | 0.507 |
FAM20C |
0.450 | 0.273 | 2 | 0.837 |
LKB1 |
0.450 | 0.075 | -3 | 0.413 |
VRK2 |
0.450 | 0.081 | 1 | 0.369 |
HIPK2 |
0.449 | 0.103 | 1 | 0.277 |
PKACG |
0.449 | 0.165 | -2 | 0.441 |
MNK1 |
0.449 | 0.106 | -2 | 0.514 |
PHKG1 |
0.449 | 0.165 | -3 | 0.670 |
TAO1 |
0.449 | 0.096 | 1 | 0.229 |
SSTK |
0.448 | 0.040 | 4 | 0.268 |
MYO3B |
0.448 | 0.106 | 2 | 0.350 |
NEK3 |
0.447 | 0.070 | 1 | 0.280 |
CDK1 |
0.447 | 0.050 | 1 | 0.288 |
PKCH |
0.447 | 0.126 | 2 | 0.287 |
CDK12 |
0.447 | 0.051 | 1 | 0.282 |
NEK1 |
0.447 | 0.069 | 1 | 0.319 |
PKCG |
0.447 | 0.137 | 2 | 0.283 |
PKG1 |
0.446 | 0.161 | -2 | 0.377 |
CDK7 |
0.446 | 0.035 | 1 | 0.335 |
BMPR2 |
0.446 | -0.021 | -2 | 0.564 |
YSK1 |
0.446 | 0.069 | 2 | 0.341 |
PRPK |
0.446 | -0.037 | -1 | 0.131 |
ERK5 |
0.445 | 0.036 | 1 | 0.413 |
GCK |
0.445 | 0.083 | 1 | 0.278 |
MNK2 |
0.445 | 0.097 | -2 | 0.490 |
TAO3 |
0.445 | 0.071 | 1 | 0.283 |
SIK |
0.445 | 0.144 | -3 | 0.744 |
MOS |
0.444 | 0.005 | 1 | 0.423 |
DYRK4 |
0.443 | 0.075 | 1 | 0.285 |
RAF1 |
0.443 | 0.064 | 1 | 0.311 |
NIM1 |
0.443 | 0.071 | 3 | 0.238 |
WNK3 |
0.443 | 0.034 | 1 | 0.305 |
CHAK1 |
0.443 | 0.065 | 2 | 0.299 |
PAK1 |
0.443 | 0.109 | -2 | 0.488 |
AURB |
0.443 | 0.080 | -2 | 0.366 |
QIK |
0.443 | 0.068 | -3 | 0.634 |
MST3 |
0.443 | 0.028 | 2 | 0.336 |
NEK4 |
0.443 | 0.018 | 1 | 0.295 |
CHAK2 |
0.442 | 0.041 | -1 | 0.188 |
MEK1 |
0.442 | -0.039 | 2 | 0.434 |
PAK2 |
0.442 | 0.091 | -2 | 0.479 |
P38A |
0.442 | 0.003 | 1 | 0.348 |
AURC |
0.441 | 0.098 | -2 | 0.371 |
PAK3 |
0.441 | 0.096 | -2 | 0.504 |
MEK5 |
0.441 | 0.015 | 2 | 0.388 |
DLK |
0.441 | 0.015 | 1 | 0.286 |
JNK2 |
0.440 | 0.004 | 1 | 0.269 |
ERK7 |
0.440 | 0.021 | 2 | 0.194 |
ATR |
0.440 | -0.014 | 1 | 0.310 |
COT |
0.440 | 0.124 | 2 | 0.450 |
MLK2 |
0.440 | 0.049 | 2 | 0.379 |
PAK6 |
0.440 | 0.080 | -2 | 0.456 |
ANKRD3 |
0.439 | 0.043 | 1 | 0.342 |
QSK |
0.439 | 0.078 | 4 | 0.280 |
MASTL |
0.439 | 0.065 | -2 | 0.531 |
ZAK |
0.438 | 0.026 | 1 | 0.252 |
MEKK1 |
0.438 | 0.034 | 1 | 0.313 |
TAK1 |
0.438 | 0.032 | 1 | 0.285 |
SNRK |
0.438 | 0.092 | 2 | 0.286 |
CAMK2G |
0.437 | -0.005 | 2 | 0.515 |
PERK |
0.437 | 0.014 | -2 | 0.496 |
NEK5 |
0.437 | 0.017 | 1 | 0.358 |
CDK16 |
0.437 | 0.013 | 1 | 0.294 |
CAMKK2 |
0.437 | -0.005 | -2 | 0.524 |
MEKK2 |
0.437 | 0.011 | 2 | 0.375 |
MLK3 |
0.436 | 0.062 | 2 | 0.306 |
CAMKK1 |
0.436 | -0.010 | -2 | 0.538 |
BRSK2 |
0.436 | 0.095 | -3 | 0.676 |
NEK8 |
0.436 | 0.020 | 2 | 0.346 |
BRSK1 |
0.435 | 0.123 | -3 | 0.725 |
JNK3 |
0.435 | -0.006 | 1 | 0.292 |
NEK2 |
0.435 | -0.019 | 2 | 0.348 |
PDHK1 |
0.435 | -0.039 | 1 | 0.316 |
MARK4 |
0.435 | 0.014 | 4 | 0.273 |
SLK |
0.435 | 0.054 | -2 | 0.434 |
CDC7 |
0.434 | -0.015 | 1 | 0.366 |
ERK2 |
0.434 | -0.009 | 1 | 0.286 |
P38B |
0.434 | -0.006 | 1 | 0.299 |
MYO3A |
0.434 | 0.057 | 1 | 0.262 |
RIPK3 |
0.434 | 0.014 | 3 | 0.218 |
MST1 |
0.434 | 0.015 | 1 | 0.275 |
NEK9 |
0.433 | -0.025 | 2 | 0.378 |
PDHK4 |
0.433 | -0.062 | 1 | 0.326 |
DSTYK |
0.433 | 0.029 | 2 | 0.476 |
YSK4 |
0.432 | -0.020 | 1 | 0.270 |
MAP3K15 |
0.432 | -0.040 | 1 | 0.253 |
P38G |
0.431 | -0.002 | 1 | 0.256 |
DNAPK |
0.431 | -0.008 | 1 | 0.183 |
STK33 |
0.431 | 0.033 | 2 | 0.253 |
RIPK2 |
0.431 | -0.011 | 1 | 0.238 |
MTOR |
0.431 | -0.018 | 1 | 0.291 |
ALK4 |
0.430 | -0.040 | -2 | 0.490 |
GRK5 |
0.430 | -0.011 | -3 | 0.391 |
MARK1 |
0.430 | 0.021 | 4 | 0.246 |
GRK6 |
0.429 | -0.039 | 1 | 0.307 |
ULK2 |
0.429 | -0.020 | 2 | 0.370 |
CDK18 |
0.429 | 0.006 | 1 | 0.323 |
MEKK3 |
0.429 | -0.052 | 1 | 0.281 |
MLK1 |
0.429 | -0.027 | 2 | 0.361 |
PAK5 |
0.428 | 0.088 | -2 | 0.361 |
BCKDK |
0.428 | 0.024 | -1 | 0.221 |
MARK2 |
0.428 | 0.009 | 4 | 0.219 |
ASK1 |
0.428 | -0.027 | 1 | 0.249 |
PRP4 |
0.427 | -0.035 | -3 | 0.308 |
SMG1 |
0.427 | -0.038 | 1 | 0.290 |
DRAK1 |
0.426 | -0.001 | 1 | 0.254 |
MEK2 |
0.426 | -0.077 | 2 | 0.398 |
TGFBR2 |
0.426 | 0.006 | -2 | 0.407 |
NEK11 |
0.426 | -0.073 | 1 | 0.260 |
ALK2 |
0.424 | -0.046 | -2 | 0.459 |
HUNK |
0.424 | -0.084 | 2 | 0.392 |
ERK1 |
0.424 | -0.022 | 1 | 0.301 |
AURA |
0.424 | 0.048 | -2 | 0.329 |
MARK3 |
0.424 | 0.009 | 4 | 0.241 |
CDK8 |
0.423 | -0.018 | 1 | 0.320 |
MLK4 |
0.423 | 0.014 | 2 | 0.312 |
OSR1 |
0.423 | 0.038 | 2 | 0.362 |
GSK3B |
0.423 | -0.037 | 4 | 0.093 |
MST2 |
0.423 | -0.036 | 1 | 0.293 |
CDK17 |
0.422 | -0.017 | 1 | 0.272 |
CDK19 |
0.422 | -0.006 | 1 | 0.314 |
ATM |
0.422 | -0.028 | 1 | 0.255 |
VRK1 |
0.422 | -0.086 | 2 | 0.384 |
P38D |
0.421 | -0.021 | 1 | 0.308 |
IKKB |
0.420 | 0.019 | -2 | 0.515 |
PAK4 |
0.420 | 0.080 | -2 | 0.353 |
NEK6 |
0.419 | -0.019 | -2 | 0.490 |
TBK1 |
0.419 | -0.057 | 1 | 0.254 |
TTK |
0.419 | 0.013 | -2 | 0.425 |
JNK1 |
0.418 | -0.026 | 1 | 0.279 |
TGFBR1 |
0.418 | -0.066 | -2 | 0.452 |
NEK7 |
0.417 | -0.065 | -3 | 0.417 |
GCN2 |
0.417 | -0.036 | 2 | 0.392 |
BMPR1B |
0.416 | -0.054 | 1 | 0.335 |
ALPHAK3 |
0.414 | -0.058 | -1 | 0.101 |
ACVR2A |
0.414 | -0.079 | -2 | 0.434 |
ULK1 |
0.414 | -0.065 | -3 | 0.389 |
PLK1 |
0.412 | -0.089 | -2 | 0.448 |
GRK7 |
0.411 | -0.045 | 1 | 0.283 |
GSK3A |
0.411 | -0.046 | 4 | 0.095 |
IKKE |
0.410 | -0.077 | 1 | 0.241 |
TLK2 |
0.409 | -0.068 | 1 | 0.258 |
TLK1 |
0.409 | -0.100 | -2 | 0.447 |
ACVR2B |
0.409 | -0.102 | -2 | 0.441 |
PLK3 |
0.408 | -0.079 | 2 | 0.445 |
GRK4 |
0.407 | -0.053 | -2 | 0.502 |
PLK4 |
0.405 | -0.049 | 2 | 0.293 |
CK2A2 |
0.404 | -0.049 | 1 | 0.383 |
BMPR1A |
0.404 | -0.074 | 1 | 0.325 |
STLK3 |
0.403 | -0.077 | 1 | 0.228 |
GRK2 |
0.402 | -0.077 | -2 | 0.423 |
TTBK2 |
0.401 | -0.117 | 2 | 0.306 |
CK2A1 |
0.400 | -0.052 | 1 | 0.359 |
IKKA |
0.400 | -0.047 | -2 | 0.488 |
GRK1 |
0.400 | -0.081 | -2 | 0.489 |
YANK3 |
0.393 | -0.033 | 2 | 0.172 |
PLK2 |
0.392 | -0.072 | -3 | 0.324 |
TTBK1 |
0.391 | -0.111 | 2 | 0.259 |
CK1D |
0.390 | -0.058 | -3 | 0.152 |
KIS |
0.389 | -0.030 | 1 | 0.323 |
CK1E |
0.384 | -0.066 | -3 | 0.185 |
CK1A2 |
0.384 | -0.073 | -3 | 0.177 |
GRK3 |
0.381 | -0.083 | -2 | 0.373 |
YANK2 |
0.376 | -0.052 | 2 | 0.200 |
LIMK2_TYR |
0.366 | 0.157 | -3 | 0.515 |
CK1G1 |
0.363 | -0.078 | -3 | 0.165 |
TESK1_TYR |
0.360 | 0.106 | 3 | 0.353 |
LIMK1_TYR |
0.359 | 0.107 | 2 | 0.421 |
WEE1_TYR |
0.357 | 0.061 | -1 | 0.128 |
TNNI3K_TYR |
0.356 | 0.065 | 1 | 0.325 |
PKMYT1_TYR |
0.355 | 0.075 | 3 | 0.298 |
TNK1 |
0.355 | 0.093 | 3 | 0.291 |
PINK1_TYR |
0.355 | 0.091 | 1 | 0.344 |
MAP2K4_TYR |
0.354 | 0.110 | -1 | 0.137 |
PDHK3_TYR |
0.352 | 0.016 | 4 | 0.308 |
TYRO3 |
0.352 | 0.059 | 3 | 0.331 |
FGR |
0.350 | 0.111 | 1 | 0.465 |
TNK2 |
0.350 | 0.085 | 3 | 0.185 |
LCK |
0.350 | 0.080 | -1 | 0.113 |
MAP2K6_TYR |
0.349 | 0.059 | -1 | 0.156 |
CK1G3 |
0.348 | -0.087 | -3 | 0.070 |
EPHA6 |
0.347 | -0.004 | -1 | 0.106 |
ABL2 |
0.346 | 0.030 | -1 | 0.191 |
AXL |
0.346 | 0.041 | 3 | 0.192 |
BTK |
0.345 | 0.020 | -1 | 0.174 |
MAP2K7_TYR |
0.345 | -0.034 | 2 | 0.437 |
NEK10_TYR |
0.345 | 0.034 | 1 | 0.211 |
ABL1 |
0.344 | 0.016 | -1 | 0.197 |
HCK |
0.344 | 0.016 | -1 | 0.118 |
DDR1 |
0.343 | -0.006 | 4 | 0.247 |
YES1 |
0.343 | 0.031 | -1 | 0.132 |
ROS1 |
0.342 | -0.027 | 3 | 0.293 |
BLK |
0.342 | 0.045 | -1 | 0.099 |
PDGFRB |
0.342 | 0.044 | 3 | 0.299 |
RET |
0.341 | 0.005 | 1 | 0.275 |
FLT3 |
0.341 | 0.004 | 3 | 0.350 |
PDHK4_TYR |
0.341 | -0.044 | 2 | 0.456 |
MST1R |
0.340 | -0.049 | 3 | 0.277 |
ITK |
0.340 | -0.010 | -1 | 0.137 |
PDGFRA |
0.340 | 0.005 | 3 | 0.326 |
TEK |
0.340 | -0.019 | 3 | 0.241 |
BMPR2_TYR |
0.339 | -0.058 | -1 | 0.112 |
TYK2 |
0.339 | -0.071 | 1 | 0.285 |
PDHK1_TYR |
0.337 | -0.057 | -1 | 0.140 |
LYN |
0.336 | -0.006 | 3 | 0.250 |
FER |
0.336 | -0.035 | 1 | 0.391 |
CSF1R |
0.336 | -0.030 | 3 | 0.281 |
TXK |
0.334 | -0.018 | 1 | 0.394 |
EPHB4 |
0.334 | -0.073 | -1 | 0.097 |
MUSK |
0.333 | -0.016 | 1 | 0.238 |
PTK6 |
0.333 | -0.023 | -1 | 0.185 |
EPHA1 |
0.333 | -0.050 | 3 | 0.227 |
EPHB3 |
0.332 | -0.054 | -1 | 0.103 |
LTK |
0.332 | -0.051 | 3 | 0.192 |
SRMS |
0.331 | -0.057 | 1 | 0.343 |
EPHA4 |
0.331 | -0.062 | 2 | 0.444 |
INSRR |
0.330 | -0.053 | 3 | 0.220 |
MERTK |
0.330 | -0.045 | 3 | 0.190 |
MATK |
0.330 | -0.017 | -1 | 0.174 |
JAK3 |
0.330 | -0.080 | 1 | 0.265 |
JAK2 |
0.330 | -0.129 | 1 | 0.271 |
BMX |
0.330 | -0.053 | -1 | 0.084 |
FGFR2 |
0.330 | -0.027 | 3 | 0.196 |
CK1A |
0.329 | -0.088 | -3 | 0.093 |
TEC |
0.329 | -0.074 | -1 | 0.096 |
EPHA3 |
0.327 | -0.074 | 2 | 0.413 |
FYN |
0.327 | -0.005 | -1 | 0.078 |
FGFR1 |
0.327 | -0.067 | 3 | 0.193 |
CK1G2 |
0.327 | -0.097 | -3 | 0.120 |
PTK2B |
0.327 | -0.061 | -1 | 0.120 |
ALK |
0.327 | -0.085 | 3 | 0.212 |
NTRK2 |
0.326 | -0.067 | 3 | 0.222 |
DDR2 |
0.326 | -0.016 | 3 | 0.180 |
KDR |
0.326 | -0.053 | 3 | 0.231 |
EPHB2 |
0.326 | -0.095 | -1 | 0.084 |
JAK1 |
0.325 | -0.105 | 1 | 0.233 |
KIT |
0.325 | -0.082 | 3 | 0.271 |
EPHB1 |
0.324 | -0.118 | 1 | 0.315 |
INSR |
0.324 | -0.073 | 3 | 0.225 |
SRC |
0.323 | -0.015 | -1 | 0.095 |
EPHA7 |
0.322 | -0.080 | 2 | 0.433 |
NTRK1 |
0.322 | -0.073 | -1 | 0.176 |
CSK |
0.322 | -0.061 | 2 | 0.418 |
EPHA5 |
0.321 | -0.064 | 2 | 0.458 |
NTRK3 |
0.321 | -0.050 | -1 | 0.169 |
FLT4 |
0.321 | -0.073 | 3 | 0.203 |
FRK |
0.319 | -0.095 | -1 | 0.118 |
MET |
0.317 | -0.097 | 3 | 0.229 |
FGFR3 |
0.317 | -0.066 | 3 | 0.180 |
ERBB2 |
0.317 | -0.100 | 1 | 0.264 |
FLT1 |
0.316 | -0.071 | -1 | 0.150 |
EPHA8 |
0.315 | -0.079 | -1 | 0.096 |
EPHA2 |
0.312 | -0.080 | -1 | 0.100 |
PTK2 |
0.309 | -0.076 | -1 | 0.075 |
IGF1R |
0.307 | -0.106 | 3 | 0.174 |
EGFR |
0.307 | -0.082 | 1 | 0.213 |
FGFR4 |
0.306 | -0.077 | -1 | 0.125 |
ERBB4 |
0.300 | -0.080 | 1 | 0.239 |
FES |
0.298 | -0.123 | -1 | 0.094 |
SYK |
0.294 | -0.118 | -1 | 0.083 |
ZAP70 |
0.288 | -0.069 | -1 | 0.082 |