Motif 1112 (n=50)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A0A0B4J1V8	PPAN-P2RY11	T233	ochoa	HCG2039996 (PPAN-P2RY11 readthrough)	None
M0QZ24	None	T35	ochoa	Glycosyl hydrolases family 38 C-terminal beta sandwich domain-containing protein	None
O00754	MAN2B1	T848	ochoa	Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide]	Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages.
O75381	PEX14	T48	ochoa	Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)	Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:24235149, PubMed:28765278, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278). Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035). {ECO:0000250\|UniProtKB:P53112, ECO:0000269\|PubMed:21525035, ECO:0000269\|PubMed:24235149, ECO:0000269\|PubMed:28765278, ECO:0000269\|PubMed:9653144}.
P04626	ERBB2	T1236	ochoa	Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.
P0DPH7	TUBA3C	T271	ochoa	Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8	TUBA3D	T271	ochoa	Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P12882	MYH1	T682	ochoa	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250\|UniProtKB:Q5SX40}.
P12883	MYH7	T678	ochoa	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305\|PubMed:26150528, ECO:0000305\|PubMed:26246073}.
P13535	MYH8	T681	ochoa	Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)	Muscle contraction.
P46013	MKI67	T1176	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T1298	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T1540	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T1784	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T2268	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T2389	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P49959	MRE11	T329	psp	Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)	Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250\|UniProtKB:Q61216, ECO:0000269\|PubMed:10888888, ECO:0000269\|PubMed:11741547, ECO:0000269\|PubMed:14657032, ECO:0000269\|PubMed:15064416, ECO:0000269\|PubMed:15790808, ECO:0000269\|PubMed:16622404, ECO:0000269\|PubMed:22078559, ECO:0000269\|PubMed:23080121, ECO:0000269\|PubMed:24316220, ECO:0000269\|PubMed:26240375, ECO:0000269\|PubMed:27814491, ECO:0000269\|PubMed:27889449, ECO:0000269\|PubMed:28867292, ECO:0000269\|PubMed:29670289, ECO:0000269\|PubMed:30464262, ECO:0000269\|PubMed:30612738, ECO:0000269\|PubMed:30787182, ECO:0000269\|PubMed:31353207, ECO:0000269\|PubMed:31537797, ECO:0000269\|PubMed:36050397, ECO:0000269\|PubMed:36563124, ECO:0000269\|PubMed:37696958, ECO:0000269\|PubMed:38128537, ECO:0000269\|PubMed:9590181, ECO:0000269\|PubMed:9651580, ECO:0000269\|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}.
P60709	ACTB	T106	ochoa	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250\|UniProtKB:Q6QAQ1, ECO:0000269\|PubMed:25255767, ECO:0000269\|PubMed:29581253, ECO:0000269\|PubMed:29925947, ECO:0000269\|PubMed:38609661, ECO:0000269\|PubMed:39321809}.
P63261	ACTG1	T106	ochoa	Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250\|UniProtKB:P63260, ECO:0000305\|PubMed:29581253}.
P68363	TUBA1B	T271	ochoa	Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]	Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269\|PubMed:34996871, ECO:0000269\|PubMed:38305685, ECO:0000269\|PubMed:38609661}.
P68366	TUBA4A	T271	ochoa	Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain)	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q02952	AKAP12	T401	ochoa	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q13164	MAPK7	T28	psp	Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)	Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250\|UniProtKB:P0C865, ECO:0000269\|PubMed:11254654, ECO:0000269\|PubMed:11278431, ECO:0000269\|PubMed:22869143, ECO:0000269\|PubMed:9384584, ECO:0000269\|PubMed:9790194}.
Q13976	PRKG1	T59	ochoa\|psp	cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)	Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269\|PubMed:10567269, ECO:0000269\|PubMed:11162591, ECO:0000269\|PubMed:11723116, ECO:0000269\|PubMed:12082086, ECO:0000269\|PubMed:14608379, ECO:0000269\|PubMed:15194681, ECO:0000269\|PubMed:16990611, ECO:0000269\|PubMed:8182057}.
Q6PEY2	TUBA3E	T271	ochoa	Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q71U36	TUBA1A	T271	ochoa	Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q8IYK8	REM2	T31	ochoa	GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2)	Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250\|UniProtKB:Q9WTY2}.
Q8N5A5	ZGPAT	T271	ochoa	Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)	Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269\|PubMed:19644445}.; FUNCTION: [Isoform 4]: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269\|PubMed:19644445}.
Q8TEH3	DENND1A	T532	ochoa	DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A)	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250\|UniProtKB:Q8K382, ECO:0000269\|PubMed:20154091, ECO:0000269\|PubMed:20937701}.
Q92766	RREB1	T1318	ochoa	Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1)	Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250\|UniProtKB:Q3UH06, ECO:0000269\|PubMed:10390538, ECO:0000269\|PubMed:12482979, ECO:0000269\|PubMed:15067362, ECO:0000269\|PubMed:17550981, ECO:0000269\|PubMed:8816445, ECO:0000269\|PubMed:9305772}.
Q9BQE3	TUBA1C	T271	ochoa	Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BY77	POLDIP3	T138	ochoa	Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)	Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269\|PubMed:18423201, ECO:0000269\|PubMed:22928037}.
Q9BYI3	HYCC1	T445	ochoa	Hyccin (Down-regulated by CTNNB1 protein A)	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable). {ECO:0000269\|PubMed:16951682, ECO:0000269\|PubMed:26571211, ECO:0000305\|PubMed:10910037}.
Q9NQ55	PPAN	T233	ochoa	Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog)	May have a role in cell growth.
Q9P227	ARHGAP23	T538	ochoa	Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Q9UKX2	MYH2	T684	ochoa	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250\|UniProtKB:P12883}.
Q9ULV3	CIZ1	T293	ochoa	Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)	May regulate the subcellular localization of CIP/WAF1.
Q9Y2J2	EPB41L3	T848	ochoa	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]	Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269\|PubMed:15334060, ECO:0000269\|PubMed:15737618, ECO:0000269\|PubMed:16420693, ECO:0000269\|PubMed:9892180}.
Q9Y2W2	WBP11	T593	ochoa	WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)	Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269\|PubMed:10593949, ECO:0000269\|PubMed:11375989, ECO:0000269\|PubMed:14640981}.
Q9Y520	PRRC2C	T887	ochoa	Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)	Required for efficient formation of stress granules. {ECO:0000269\|PubMed:29395067}.
Q9Y623	MYH4	T682	ochoa	Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)	Muscle contraction.
V9GY48	None	T177	ochoa	Zinc finger CCCH-type with G patch domain-containing protein	None
P33992	MCM5	T633	EPSD\|PSP	DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)	Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269\|PubMed:16899510, ECO:0000269\|PubMed:32453425, ECO:0000269\|PubMed:34694004, ECO:0000269\|PubMed:34700328, ECO:0000269\|PubMed:35585232}.
P62899	RPL31	T107	Sugiyama	Large ribosomal subunit protein eL31 (60S ribosomal protein L31)	Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547}.
Q562R1	ACTBL2	T107	Sugiyama	Beta-actin-like protein 2 (Kappa-actin)	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}.
Q13228	SELENBP1	T38	Sugiyama	Methanethiol oxidase (MTO) (EC 1.8.3.4) (56 kDa selenium-binding protein) (SBP56) (SP56) (Selenium-binding protein 1)	Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250\|UniProtKB:Q8VIF7, ECO:0000269\|PubMed:29255262}.
Q99759	MAP3K3	T307	Sugiyama	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)	Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269\|PubMed:12912994, ECO:0000269\|PubMed:14661019, ECO:0000269\|PubMed:14743216, ECO:0000269\|PubMed:33729480, ECO:0000269\|PubMed:33891857, ECO:0000269\|PubMed:9006902}.
Q02952	AKAP12	T951	Sugiyama	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
P61163	ACTR1A	T111	Sugiyama	Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)	Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250\|UniProtKB:F2Z5G5}.
P22314	UBA1	T633	Sugiyama	Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269\|PubMed:1447181, ECO:0000269\|PubMed:1606621, ECO:0000269\|PubMed:22456334, ECO:0000269\|PubMed:33108101}.

Download

reactome_id	name	p	-log10_p
R-HSA-190828	Gap junction trafficking	5.717649e-14	13.243
R-HSA-437239	Recycling pathway of L1	9.403589e-14	13.027
R-HSA-157858	Gap junction trafficking and regulation	1.292300e-13	12.889
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	2.701173e-13	12.568
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	6.228351e-13	12.206
R-HSA-190872	Transport of connexons to the plasma membrane	8.483214e-13	12.071
R-HSA-389977	Post-chaperonin tubulin folding pathway	1.513900e-12	11.820
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	2.897238e-12	11.538
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	5.364376e-12	11.270
R-HSA-9619483	Activation of AMPK downstream of NMDARs	1.276868e-11	10.894
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	1.801970e-11	10.744
R-HSA-9668328	Sealing of the nuclear envelope (NE) by ESCRT-III	3.299172e-11	10.482
R-HSA-190861	Gap junction assembly	4.661260e-11	10.331
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	7.853107e-11	10.105
R-HSA-9646399	Aggrephagy	1.196442e-10	9.922
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	1.594564e-10	9.797
R-HSA-373760	L1CAM interactions	1.838881e-10	9.735
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	3.531809e-10	9.452
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	3.923609e-10	9.406
R-HSA-390466	Chaperonin-mediated protein folding	4.869435e-10	9.313
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	5.278628e-10	9.277
R-HSA-391251	Protein folding	7.804422e-10	9.108
R-HSA-6807878	COPI-mediated anterograde transport	1.131882e-09	8.946
R-HSA-983189	Kinesins	1.515053e-09	8.820
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	1.847626e-09	8.733
R-HSA-5620920	Cargo trafficking to the periciliary membrane	4.222768e-09	8.374
R-HSA-2132295	MHC class II antigen presentation	7.649464e-09	8.116
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	8.807741e-09	8.055
R-HSA-9833482	PKR-mediated signaling	8.807741e-09	8.055
R-HSA-8856688	Golgi-to-ER retrograde transport	1.384748e-08	7.859
R-HSA-438064	Post NMDA receptor activation events	1.590855e-08	7.798
R-HSA-9663891	Selective autophagy	1.706730e-08	7.768
R-HSA-5620924	Intraflagellar transport	1.915152e-08	7.718
R-HSA-199977	ER to Golgi Anterograde Transport	3.182564e-08	7.497
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	3.317073e-08	7.479
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	4.795131e-08	7.319
R-HSA-422475	Axon guidance	7.589201e-08	7.120
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	7.603116e-08	7.119
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	1.089871e-07	6.963
R-HSA-9675108	Nervous system development	1.500281e-07	6.824
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	1.585815e-07	6.800
R-HSA-69275	G2/M Transition	1.653434e-07	6.782
R-HSA-5617833	Cilium Assembly	1.912798e-07	6.718
R-HSA-453274	Mitotic G2-G2/M phases	1.779059e-07	6.750
R-HSA-68877	Mitotic Prometaphase	2.129574e-07	6.672
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	2.718988e-07	6.566
R-HSA-948021	Transport to the Golgi and subsequent modification	2.911142e-07	6.536
R-HSA-1632852	Macroautophagy	4.531083e-07	6.344
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	7.956373e-07	6.099
R-HSA-9612973	Autophagy	8.588544e-07	6.066
R-HSA-5610787	Hedgehog 'off' state	1.027031e-06	5.988
R-HSA-2467813	Separation of Sister Chromatids	1.155604e-06	5.937
R-HSA-199991	Membrane Trafficking	3.445009e-06	5.463
R-HSA-9609690	HCMV Early Events	3.446165e-06	5.463
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	5.651573e-06	5.248
R-HSA-68882	Mitotic Anaphase	6.313227e-06	5.200
R-HSA-2555396	Mitotic Metaphase and Anaphase	6.488349e-06	5.188
R-HSA-5358351	Signaling by Hedgehog	6.900526e-06	5.161
R-HSA-1852241	Organelle biogenesis and maintenance	7.011284e-06	5.154
R-HSA-9609646	HCMV Infection	1.500972e-05	4.824
R-HSA-68886	M Phase	2.373638e-05	4.625
R-HSA-5653656	Vesicle-mediated transport	2.574628e-05	4.589
R-HSA-69278	Cell Cycle, Mitotic	5.237550e-05	4.281
R-HSA-1640170	Cell Cycle	4.845108e-05	4.315
R-HSA-446203	Asparagine N-linked glycosylation	4.628434e-05	4.335
R-HSA-112315	Transmission across Chemical Synapses	6.805969e-05	4.167
R-HSA-112316	Neuronal System	9.205519e-05	4.036
R-HSA-913531	Interferon Signaling	1.866918e-04	3.729
R-HSA-2262752	Cellular responses to stress	1.949669e-04	3.710
R-HSA-1266738	Developmental Biology	4.158282e-04	3.381
R-HSA-196025	Formation of annular gap junctions	5.154573e-04	3.288
R-HSA-9825895	Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ...	5.154573e-04	3.288
R-HSA-8953897	Cellular responses to stimuli	5.242423e-04	3.280
R-HSA-109582	Hemostasis	5.529916e-04	3.257
R-HSA-190873	Gap junction degradation	6.122722e-04	3.213
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	9.499093e-04	3.022
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	1.278162e-03	2.893
R-HSA-380259	Loss of Nlp from mitotic centrosomes	1.278162e-03	2.893
R-HSA-1280218	Adaptive Immune System	1.034082e-03	2.985
R-HSA-8854518	AURKA Activation by TPX2	1.438115e-03	2.842
R-HSA-446353	Cell-extracellular matrix interactions	1.514667e-03	2.820
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	1.551428e-03	2.809
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptor...	1.843320e-03	2.734
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	1.858781e-03	2.731
R-HSA-380287	Centrosome maturation	1.991595e-03	2.701
R-HSA-168256	Immune System	2.060842e-03	2.686
R-HSA-9659379	Sensory processing of sound	2.274640e-03	2.643
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	2.661986e-03	2.575
R-HSA-9938206	Developmental Lineage of Mammary Stem Cells	3.233821e-03	2.490
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	3.269142e-03	2.486
R-HSA-445095	Interaction between L1 and Ankyrins	4.449558e-03	2.352
R-HSA-1280215	Cytokine Signaling in Immune system	4.603494e-03	2.337
R-HSA-9927432	Developmental Lineage of Mammary Gland Myoepithelial Cells	4.986340e-03	2.302
R-HSA-9913351	Formation of the dystrophin-glycoprotein complex (DGC)	5.551452e-03	2.256
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	7.747553e-03	2.111
R-HSA-5674135	MAP2K and MAPK activation	9.518170e-03	2.021
R-HSA-9656223	Signaling by RAF1 mutants	9.518170e-03	2.021
R-HSA-597592	Post-translational protein modification	9.287451e-03	2.032
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	9.891956e-03	2.005
R-HSA-5663205	Infectious disease	1.063843e-02	1.973
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	1.065887e-02	1.972
R-HSA-3928662	EPHB-mediated forward signaling	1.065887e-02	1.972
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	1.145130e-02	1.941
R-HSA-9649948	Signaling downstream of RAS mutants	1.145130e-02	1.941
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	1.145130e-02	1.941
R-HSA-6802949	Signaling by RAS mutants	1.145130e-02	1.941
R-HSA-9664407	Parasite infection	1.156338e-02	1.937
R-HSA-9664422	FCGR3A-mediated phagocytosis	1.156338e-02	1.937
R-HSA-9664417	Leishmania phagocytosis	1.156338e-02	1.937
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	1.176145e-02	1.930
R-HSA-9665230	Drug resistance in ERBB2 KD mutants	1.185391e-02	1.926
R-HSA-9652282	Drug-mediated inhibition of ERBB2 signaling	1.185391e-02	1.926
R-HSA-198765	Signalling to ERK5	1.185391e-02	1.926
R-HSA-9665249	Resistance of ERBB2 KD mutants to afatinib	1.185391e-02	1.926
R-HSA-9665245	Resistance of ERBB2 KD mutants to tesevatinib	1.185391e-02	1.926
R-HSA-9665251	Resistance of ERBB2 KD mutants to lapatinib	1.185391e-02	1.926
R-HSA-9665233	Resistance of ERBB2 KD mutants to trastuzumab	1.185391e-02	1.926
R-HSA-9665250	Resistance of ERBB2 KD mutants to AEE788	1.185391e-02	1.926
R-HSA-9665246	Resistance of ERBB2 KD mutants to neratinib	1.185391e-02	1.926
R-HSA-9665247	Resistance of ERBB2 KD mutants to osimertinib	1.185391e-02	1.926
R-HSA-9665244	Resistance of ERBB2 KD mutants to sapitinib	1.185391e-02	1.926
R-HSA-9665737	Drug resistance in ERBB2 TMD/JMD mutants	1.185391e-02	1.926
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	1.185699e-02	1.926
R-HSA-9856651	MITF-M-dependent gene expression	1.385033e-02	1.859
R-HSA-9764561	Regulation of CDH1 Function	1.625183e-02	1.789
R-HSA-1251932	PLCG1 events in ERBB2 signaling	1.772915e-02	1.751
R-HSA-1306955	GRB7 events in ERBB2 signaling	1.772915e-02	1.751
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	2.019269e-02	1.695
R-HSA-9924644	Developmental Lineages of the Mammary Gland	2.393460e-02	1.621
R-HSA-8852135	Protein ubiquitination	2.561893e-02	1.591
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	1.994593e-02	1.700
R-HSA-3000171	Non-integrin membrane-ECM interactions	2.561893e-02	1.591
R-HSA-162582	Signal Transduction	2.821319e-02	1.550
R-HSA-9824446	Viral Infection Pathways	1.932084e-02	1.714
R-HSA-6802957	Oncogenic MAPK signaling	3.156776e-02	1.501
R-HSA-9730414	MITF-M-regulated melanocyte development	3.233104e-02	1.490
R-HSA-176974	Unwinding of DNA	3.515042e-02	1.454
R-HSA-8853383	Lysosomal oligosaccharide catabolism	3.515042e-02	1.454
R-HSA-2682334	EPH-Ephrin signaling	3.734035e-02	1.428
R-HSA-390450	Folding of actin by CCT/TriC	3.802440e-02	1.420
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN...	3.802440e-02	1.420
R-HSA-202670	ERKs are inactivated	4.374724e-02	1.359
R-HSA-5693548	Sensing of DNA Double Strand Breaks	4.374724e-02	1.359
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	4.659614e-02	1.332
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	4.943673e-02	1.306
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	5.226903e-02	1.282
R-HSA-6785631	ERBB2 Regulates Cell Motility	5.509307e-02	1.259
R-HSA-1963640	GRB2 events in ERBB2 signaling	6.071646e-02	1.217
R-HSA-1963642	PI3K events in ERBB2 signaling	6.351585e-02	1.197
R-HSA-9665348	Signaling by ERBB2 ECD mutants	6.630707e-02	1.178
R-HSA-9709603	Impaired BRCA2 binding to PALB2	6.909014e-02	1.161
R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	7.186509e-02	1.143
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	7.186509e-02	1.143
R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	7.186509e-02	1.143
R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	7.186509e-02	1.143
R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	7.186509e-02	1.143
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	8.561881e-02	1.067
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD...	8.834550e-02	1.054
R-HSA-418457	cGMP effects	5.226903e-02	1.282
R-HSA-198753	ERK/MAPK targets	7.463194e-02	1.127
R-HSA-9933947	Formation of the non-canonical BAF (ncBAF) complex	4.943673e-02	1.306
R-HSA-9603798	Class I peroxisomal membrane protein import	5.790887e-02	1.237
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	7.186509e-02	1.143
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	4.997840e-02	1.301
R-HSA-8856828	Clathrin-mediated endocytosis	8.339120e-02	1.079
R-HSA-9932451	SWI/SNF chromatin remodelers	8.834550e-02	1.054
R-HSA-9932444	ATP-dependent chromatin remodelers	8.834550e-02	1.054
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	4.659614e-02	1.332
R-HSA-400685	Sema4D in semaphorin signaling	8.834550e-02	1.054
R-HSA-69481	G2/M Checkpoints	6.718602e-02	1.173
R-HSA-9933937	Formation of the canonical BAF (cBAF) complex	5.226903e-02	1.282
R-HSA-3270619	IRF3-mediated induction of type I IFN	5.509307e-02	1.259
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	5.509307e-02	1.259
R-HSA-9933939	Formation of the polybromo-BAF (pBAF) complex	5.226903e-02	1.282
R-HSA-392517	Rap1 signalling	6.909014e-02	1.161
R-HSA-5673001	RAF/MAP kinase cascade	6.459332e-02	1.190
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	6.909014e-02	1.161
R-HSA-5684996	MAPK1/MAPK3 signaling	6.811011e-02	1.167
R-HSA-392499	Metabolism of proteins	4.968704e-02	1.304
R-HSA-9824443	Parasitic Infection Pathways	6.068206e-02	1.217
R-HSA-9658195	Leishmania infection	6.068206e-02	1.217
R-HSA-1834941	STING mediated induction of host immune responses	6.909014e-02	1.161
R-HSA-1643685	Disease	7.086449e-02	1.150
R-HSA-4420097	VEGFA-VEGFR2 Pathway	5.679904e-02	1.246
R-HSA-194138	Signaling by VEGF	6.554891e-02	1.183
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	9.377503e-02	1.028
R-HSA-5683057	MAPK family signaling cascades	9.625443e-02	1.017
R-HSA-9664565	Signaling by ERBB2 KD Mutants	9.917289e-02	1.004
R-HSA-9709570	Impaired BRCA2 binding to RAD51	9.917289e-02	1.004
R-HSA-392154	Nitric oxide stimulates guanylate cyclase	9.917289e-02	1.004
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	9.917289e-02	1.004
R-HSA-1227990	Signaling by ERBB2 in Cancer	1.018600e-01	0.992
R-HSA-68962	Activation of the pre-replicative complex	1.018600e-01	0.992
R-HSA-1250196	SHC1 events in ERBB2 signaling	1.018600e-01	0.992
R-HSA-8863795	Downregulation of ERBB2 signaling	1.018600e-01	0.992
R-HSA-69190	DNA strand elongation	1.072107e-01	0.970
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	1.098743e-01	0.959
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	1.098743e-01	0.959
R-HSA-176187	Activation of ATR in response to replication stress	1.098743e-01	0.959
R-HSA-9764265	Regulation of CDH1 Expression and Function	1.120348e-01	0.951
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	1.120348e-01	0.951
R-HSA-390522	Striated Muscle Contraction	1.125302e-01	0.949
R-HSA-5693537	Resolution of D-Loop Structures	1.125302e-01	0.949
R-HSA-5696394	DNA Damage Recognition in GG-NER	1.125302e-01	0.949
R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	1.151783e-01	0.939
R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	1.151783e-01	0.939
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	1.178186e-01	0.929
R-HSA-2559583	Cellular Senescence	1.188226e-01	0.925
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	1.197182e-01	0.922
R-HSA-8853659	RET signaling	1.204513e-01	0.919
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	1.256935e-01	0.901
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	1.347100e-01	0.871
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	1.463581e-01	0.835
R-HSA-9675135	Diseases of DNA repair	1.489074e-01	0.827
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	1.539834e-01	0.813
R-HSA-418990	Adherens junctions interactions	1.583236e-01	0.800
R-HSA-912446	Meiotic recombination	1.615420e-01	0.792
R-HSA-72187	mRNA 3'-end processing	1.640468e-01	0.785
R-HSA-68949	Orc1 removal from chromatin	1.640468e-01	0.785
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	1.640468e-01	0.785
R-HSA-6794361	Neurexins and neuroligins	1.640468e-01	0.785
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	1.665443e-01	0.778
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	1.813765e-01	0.741
R-HSA-9033241	Peroxisomal protein import	1.813765e-01	0.741
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	1.838232e-01	0.736
R-HSA-1227986	Signaling by ERBB2	1.838232e-01	0.736
R-HSA-73856	RNA Polymerase II Transcription Termination	1.862628e-01	0.730
R-HSA-450294	MAP kinase activation	1.862628e-01	0.730
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	1.886953e-01	0.724
R-HSA-373755	Semaphorin interactions	1.911207e-01	0.719
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	1.911207e-01	0.719
R-HSA-8848021	Signaling by PTK6	1.911207e-01	0.719
R-HSA-421270	Cell-cell junction organization	1.934136e-01	0.714
R-HSA-5693606	DNA Double Strand Break Response	2.007513e-01	0.697
R-HSA-5685942	HDR through Homologous Recombination (HRR)	2.007513e-01	0.697
R-HSA-69620	Cell Cycle Checkpoints	2.009936e-01	0.697
R-HSA-9734767	Developmental Cell Lineages	2.064307e-01	0.685
R-HSA-448424	Interleukin-17 signaling	2.079004e-01	0.682
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	2.079004e-01	0.682
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	2.102696e-01	0.677
R-HSA-168249	Innate Immune System	2.116793e-01	0.674
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	2.126317e-01	0.672
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	2.142468e-01	0.669
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	2.149870e-01	0.668
R-HSA-69052	Switching of origins to a post-replicative state	2.149870e-01	0.668
R-HSA-4086398	Ca2+ pathway	2.149870e-01	0.668
R-HSA-69473	G2/M DNA damage checkpoint	2.173353e-01	0.663
R-HSA-5689603	UCH proteinases	2.220114e-01	0.654
R-HSA-446728	Cell junction organization	2.228376e-01	0.652
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	2.239358e-01	0.650
R-HSA-5693607	Processing of DNA double-strand break ends	2.335823e-01	0.632
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	2.358762e-01	0.627
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	2.358762e-01	0.627
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	2.404438e-01	0.619
R-HSA-1500620	Meiosis	2.427176e-01	0.615
R-HSA-6794362	Protein-protein interactions at synapses	2.427176e-01	0.615
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	2.449847e-01	0.611
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	2.472451e-01	0.607
R-HSA-8953854	Metabolism of RNA	2.507608e-01	0.601
R-HSA-156902	Peptide chain elongation	2.517462e-01	0.599
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	2.584484e-01	0.588
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	2.606694e-01	0.584
R-HSA-156842	Eukaryotic Translation Elongation	2.628838e-01	0.580
R-HSA-1500931	Cell-Cell communication	2.648047e-01	0.577
R-HSA-68867	Assembly of the pre-replicative complex	2.650918e-01	0.577
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	2.672933e-01	0.573
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri...	2.694883e-01	0.569
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	2.716769e-01	0.566
R-HSA-72764	Eukaryotic Translation Termination	2.716769e-01	0.566
R-HSA-72689	Formation of a pool of free 40S subunits	2.716769e-01	0.566
R-HSA-975871	MyD88 cascade initiated on plasma membrane	2.782042e-01	0.556
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	2.782042e-01	0.556
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	2.782042e-01	0.556
R-HSA-3214847	HATs acetylate histones	2.803672e-01	0.552
R-HSA-1474244	Extracellular matrix organization	2.814292e-01	0.551
R-HSA-2408557	Selenocysteine synthesis	2.846743e-01	0.546
R-HSA-9020702	Interleukin-1 signaling	2.846743e-01	0.546
R-HSA-9842860	Regulation of endogenous retroelements	2.868183e-01	0.542
R-HSA-192823	Viral mRNA Translation	2.889560e-01	0.539
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	2.910875e-01	0.536
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	2.953317e-01	0.530
R-HSA-5696398	Nucleotide Excision Repair	2.953317e-01	0.530
R-HSA-418346	Platelet homeostasis	2.974444e-01	0.527
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	2.995510e-01	0.524
R-HSA-69239	Synthesis of DNA	2.995510e-01	0.524
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	3.016513e-01	0.520
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.016513e-01	0.520
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	3.016513e-01	0.520
R-HSA-69002	DNA Replication Pre-Initiation	3.037455e-01	0.517
R-HSA-975155	MyD88 dependent cascade initiated on endosome	3.037455e-01	0.517
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	3.058336e-01	0.515
R-HSA-166166	MyD88-independent TLR4 cascade	3.058336e-01	0.515
R-HSA-927802	Nonsense-Mediated Decay (NMD)	3.099913e-01	0.509
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	3.099913e-01	0.509
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	3.120610e-01	0.506
R-HSA-73894	DNA Repair	3.134938e-01	0.504
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	3.141246e-01	0.503
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	3.182337e-01	0.497
R-HSA-72613	Eukaryotic Translation Initiation	3.223186e-01	0.492
R-HSA-72737	Cap-dependent Translation Initiation	3.223186e-01	0.492
R-HSA-9007101	Rab regulation of trafficking	3.243521e-01	0.489
R-HSA-5693538	Homology Directed Repair	3.263796e-01	0.486
R-HSA-2219528	PI3K/AKT Signaling in Cancer	3.263796e-01	0.486
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	3.284012e-01	0.484
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	3.284012e-01	0.484
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	3.344303e-01	0.476
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	3.344303e-01	0.476
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	3.364282e-01	0.473
R-HSA-69206	G1/S Transition	3.423867e-01	0.465
R-HSA-114608	Platelet degranulation	3.463299e-01	0.461
R-HSA-187037	Signaling by NTRK1 (TRKA)	3.482928e-01	0.458
R-HSA-199418	Negative regulation of the PI3K/AKT network	3.522013e-01	0.453
R-HSA-1474165	Reproduction	3.541470e-01	0.451
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	3.599496e-01	0.444
R-HSA-3858494	Beta-catenin independent WNT signaling	3.676072e-01	0.435
R-HSA-9948299	Ribosome-associated quality control	3.714022e-01	0.430
R-HSA-453279	Mitotic G1 phase and G1/S transition	3.882058e-01	0.411
R-HSA-69242	S Phase	3.918798e-01	0.407
R-HSA-166520	Signaling by NTRKs	3.918798e-01	0.407
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	3.918798e-01	0.407
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	3.991630e-01	0.399
R-HSA-446652	Interleukin-1 family signaling	3.991630e-01	0.399
R-HSA-5693532	DNA Double-Strand Break Repair	4.009705e-01	0.397
R-HSA-9609507	Protein localization	4.009705e-01	0.397
R-HSA-69306	DNA Replication	4.009705e-01	0.397
R-HSA-168273	Influenza Viral RNA Transcription and Replication	4.045694e-01	0.393
R-HSA-9711097	Cellular response to starvation	4.099280e-01	0.387
R-HSA-5633007	Regulation of TP53 Activity	4.134742e-01	0.384
R-HSA-2408522	Selenoamino acid metabolism	4.205041e-01	0.376
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	4.326084e-01	0.364
R-HSA-168255	Influenza Infection	4.478078e-01	0.349
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.626083e-01	0.335
R-HSA-168898	Toll-like Receptor Cascades	4.674550e-01	0.330
R-HSA-72163	mRNA Splicing - Major Pathway	4.722588e-01	0.326
R-HSA-376176	Signaling by ROBO receptors	4.864171e-01	0.313
R-HSA-72172	mRNA Splicing	4.895125e-01	0.310
R-HSA-397014	Muscle contraction	5.017126e-01	0.300
R-HSA-72312	rRNA processing	5.309773e-01	0.275
R-HSA-3247509	Chromatin modifying enzymes	5.338094e-01	0.273
R-HSA-4839726	Chromatin organization	5.545236e-01	0.256
R-HSA-5688426	Deubiquitination	5.625545e-01	0.250
R-HSA-416476	G alpha (q) signalling events	5.743357e-01	0.241
R-HSA-449147	Signaling by Interleukins	5.788036e-01	0.237
R-HSA-76002	Platelet activation, signaling and aggregation	5.870617e-01	0.231
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	5.969736e-01	0.224
R-HSA-1257604	PIP3 activates AKT signaling	6.125858e-01	0.213
R-HSA-195721	Signaling by WNT	6.161036e-01	0.210
R-HSA-212165	Epigenetic regulation of gene expression	6.442277e-01	0.191
R-HSA-9006925	Intracellular signaling by second messengers	6.642429e-01	0.178
R-HSA-983169	Class I MHC mediated antigen processing & presentation	7.046551e-01	0.152
R-HSA-74160	Gene expression (Transcription)	7.231640e-01	0.141
R-HSA-9709957	Sensory Perception	7.346331e-01	0.134
R-HSA-72766	Translation	7.434583e-01	0.129
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	7.631337e-01	0.117
R-HSA-6798695	Neutrophil degranulation	7.645844e-01	0.117
R-HSA-73857	RNA Polymerase II Transcription	7.662112e-01	0.116
R-HSA-3700989	Transcriptional Regulation by TP53	7.703009e-01	0.113
R-HSA-71291	Metabolism of amino acids and derivatives	8.568068e-01	0.067
R-HSA-212436	Generic Transcription Pathway	8.602360e-01	0.065
R-HSA-388396	GPCR downstream signalling	9.119844e-01	0.040
R-HSA-372790	Signaling by GPCR	9.322008e-01	0.030
R-HSA-1430728	Metabolism	9.999559e-01	0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
BUB1	0.642	0.324	-5	0.655
CAMKK2	0.641	0.219	-2	0.697
P38B	0.640	0.177	1	0.633
NEK1	0.636	0.118	1	0.542
CAMKK1	0.634	0.148	-2	0.706
P38D	0.633	0.182	1	0.556
LKB1	0.632	0.147	-3	0.421
P38A	0.631	0.151	1	0.644
MPSK1	0.631	0.161	1	0.559
ERK5	0.628	0.249	1	0.699
JNK2	0.628	0.127	1	0.567
VRK2	0.627	-0.017	1	0.648
AAK1	0.626	0.057	1	0.457
GAK	0.626	-0.056	1	0.601
VRK1	0.625	-0.071	2	0.512
BIKE	0.624	0.018	1	0.520
LRRK2	0.624	-0.052	2	0.493
NEK4	0.621	0.039	1	0.512
JNK3	0.620	0.101	1	0.616
TNIK	0.620	0.000	3	0.509
NEK5	0.620	0.031	1	0.565
PBK	0.620	0.041	1	0.542
PKR	0.620	-0.014	1	0.611
MYO3B	0.618	-0.005	2	0.518
TAK1	0.618	-0.092	1	0.507
ASK1	0.617	-0.052	1	0.478
EEF2K	0.617	-0.043	3	0.422
MAK	0.615	0.106	-2	0.507
NLK	0.613	0.114	1	0.665
PRP4	0.613	0.065	-3	0.328
HGK	0.612	-0.036	3	0.497
MST2	0.612	-0.057	1	0.512
MAP3K15	0.612	-0.018	1	0.477
PDK1	0.612	-0.069	1	0.552
KHS1	0.612	-0.026	1	0.495
ERK1	0.611	0.140	1	0.602
DYRK2	0.611	0.147	1	0.656
HIPK1	0.611	0.118	1	0.658
PASK	0.611	0.035	-3	0.439
HIPK4	0.610	0.230	1	0.671
P38G	0.610	0.117	1	0.542
NIK	0.610	-0.070	-3	0.402
LATS1	0.609	0.106	-3	0.463
MST1	0.609	-0.069	1	0.503
ERK7	0.609	0.046	2	0.366
MEK1	0.609	-0.130	2	0.473
MINK	0.609	-0.089	1	0.485
MEKK6	0.608	-0.052	1	0.510
CAMLCK	0.608	-0.040	-2	0.563
MOK	0.608	0.074	1	0.686
GCK	0.608	-0.054	1	0.482
MYO3A	0.608	-0.073	1	0.521
BRAF	0.607	-0.104	-4	0.638
MLK2	0.607	0.050	2	0.511
TAO2	0.607	-0.092	2	0.535
JNK1	0.607	0.092	1	0.592
HPK1	0.607	-0.063	1	0.473
DAPK2	0.606	-0.061	-3	0.406
MOS	0.606	0.057	1	0.676
ERK2	0.606	0.103	1	0.633
KHS2	0.606	-0.042	1	0.490
LOK	0.606	-0.007	-2	0.564
ALPHAK3	0.606	-0.065	-1	0.582
BMPR2	0.605	-0.117	-2	0.554
MEK2	0.605	-0.113	2	0.440
MST3	0.604	-0.058	2	0.584
YSK1	0.604	-0.068	2	0.513
CDK18	0.604	0.169	1	0.587
HIPK3	0.604	0.110	1	0.632
CDK16	0.603	0.140	1	0.582
CAMK1B	0.603	-0.052	-3	0.385
PRPK	0.603	-0.049	-1	0.651
MEKK1	0.602	-0.069	1	0.519
ALK4	0.602	-0.028	-2	0.467
ICK	0.602	0.014	-3	0.405
CDK14	0.602	0.105	1	0.602
CDKL1	0.602	-0.016	-3	0.356
MEK5	0.602	-0.179	2	0.473
NEK11	0.601	-0.113	1	0.490
DYRK4	0.601	0.136	1	0.605
MEKK2	0.601	-0.153	2	0.478
ATR	0.600	-0.013	1	0.597
CDK5	0.600	0.109	1	0.625
ALK2	0.600	-0.012	-2	0.469
ROCK2	0.600	-0.027	-3	0.346
DMPK1	0.599	-0.055	-3	0.313
OSR1	0.599	-0.075	2	0.454
CHAK2	0.599	0.054	-1	0.638
NEK2	0.599	0.005	2	0.500
NEK8	0.598	-0.112	2	0.500
TAO3	0.598	-0.076	1	0.521
TGFBR1	0.598	-0.006	-2	0.440
CDK17	0.598	0.134	1	0.559
NEK9	0.597	0.005	2	0.510
YSK4	0.596	-0.072	1	0.478
CDKL5	0.596	0.035	-3	0.364
CDK4	0.595	0.078	1	0.587
SKMLCK	0.595	-0.020	-2	0.551
DLK	0.595	-0.127	1	0.553
NEK3	0.594	-0.040	1	0.487
TTK	0.594	-0.141	-2	0.457
DYRK1A	0.594	0.061	1	0.651
HASPIN	0.594	0.002	-1	0.541
HIPK2	0.594	0.147	1	0.595
ANKRD3	0.593	-0.160	1	0.563
TSSK2	0.593	-0.012	-5	0.696
CDK6	0.592	0.067	1	0.582
CLK3	0.592	0.122	1	0.754
CHK1	0.592	0.026	-3	0.398
PERK	0.592	-0.050	-2	0.509
SMMLCK	0.591	-0.107	-3	0.355
STLK3	0.591	-0.166	1	0.453
DAPK3	0.591	-0.077	-3	0.340
BMPR1B	0.591	0.004	1	0.577
GRK6	0.590	-0.016	1	0.636
GRK5	0.590	-0.036	-3	0.403
CDK1	0.590	0.087	1	0.600
GRK7	0.590	0.039	1	0.665
IRAK4	0.590	-0.062	1	0.570
CDK3	0.589	0.094	1	0.571
DYRK1B	0.589	0.090	1	0.620
ZAK	0.589	-0.124	1	0.482
CDK9	0.588	0.096	1	0.609
CDK7	0.588	0.130	1	0.604
PINK1	0.588	-0.055	1	0.639
TAO1	0.588	-0.075	1	0.445
SLK	0.587	-0.043	-2	0.501
CDK13	0.587	0.100	1	0.603
CRIK	0.587	-0.032	-3	0.321
DNAPK	0.586	-0.018	1	0.477
CDK8	0.586	0.122	1	0.584
CDK2	0.586	0.039	1	0.665
PDHK1	0.585	-0.067	1	0.586
PDHK4	0.585	-0.127	1	0.606
DYRK3	0.585	0.042	1	0.652
RAF1	0.585	-0.120	1	0.560
CDC7	0.585	0.087	1	0.637
WNK4	0.584	-0.107	-2	0.584
SMG1	0.584	-0.012	1	0.560
ROCK1	0.584	-0.062	-3	0.297
MASTL	0.584	-0.146	-2	0.559
AMPKA1	0.584	-0.029	-3	0.407
MLK3	0.583	-0.007	2	0.522
ACVR2B	0.583	-0.058	-2	0.437
WNK1	0.583	-0.061	-2	0.582
GSK3B	0.582	-0.005	4	0.356
TSSK1	0.582	-0.009	-3	0.433
HRI	0.582	-0.142	-2	0.500
TLK2	0.582	-0.057	1	0.525
DSTYK	0.582	-0.028	2	0.581
CAMK2G	0.582	-0.115	2	0.413
CDK19	0.581	0.146	1	0.562
NUAK2	0.581	-0.032	-3	0.385
CDK12	0.581	0.081	1	0.584
MLK1	0.581	-0.105	2	0.534
GSK3A	0.581	0.014	4	0.364
HUNK	0.581	-0.058	2	0.508
PIM1	0.580	-0.047	-3	0.331
MEKK3	0.580	-0.246	1	0.505
CLK4	0.579	0.020	-3	0.308
MARK4	0.579	-0.025	4	0.671
PIM2	0.579	-0.051	-3	0.311
MRCKB	0.579	-0.058	-3	0.296
PRKD1	0.579	0.111	-3	0.436
PKN3	0.579	-0.064	-3	0.367
CDK10	0.579	0.073	1	0.590
MAPKAPK3	0.579	0.038	-3	0.358
GRK1	0.578	0.065	-2	0.511
ACVR2A	0.578	-0.076	-2	0.410
PIM3	0.578	-0.016	-3	0.391
CHAK1	0.578	-0.068	2	0.465
RIPK1	0.578	-0.162	1	0.550
NEK6	0.578	0.051	-2	0.541
SRPK1	0.578	0.030	-3	0.324
DAPK1	0.577	-0.098	-3	0.323
PKCD	0.577	-0.042	2	0.506
DCAMKL1	0.577	-0.073	-3	0.346
SBK	0.577	-0.016	-3	0.205
AMPKA2	0.576	-0.020	-3	0.385
TLK1	0.576	-0.112	-2	0.460
BMPR1A	0.576	-0.036	1	0.569
P70S6KB	0.576	-0.048	-3	0.336
COT	0.576	-0.050	2	0.539
SGK3	0.576	-0.046	-3	0.337
RIPK3	0.575	-0.108	3	0.413
PKN2	0.575	-0.079	-3	0.375
MTOR	0.574	-0.061	1	0.605
CAMK2D	0.574	-0.058	-3	0.398
PRKD3	0.574	0.005	-3	0.325
PRKD2	0.574	0.076	-3	0.372
MRCKA	0.573	-0.077	-3	0.302
NEK7	0.573	-0.063	-3	0.465
DCAMKL2	0.572	-0.096	-3	0.358
PKCZ	0.572	-0.043	2	0.497
PAK6	0.572	0.108	-2	0.503
MELK	0.572	-0.062	-3	0.364
MYLK4	0.571	-0.083	-2	0.505
PKCA	0.571	-0.015	2	0.502
CLK1	0.571	0.021	-3	0.305
RSK2	0.570	-0.008	-3	0.348
AKT2	0.570	-0.042	-3	0.274
PLK1	0.570	-0.169	-2	0.504
PKCB	0.569	-0.015	2	0.528
IRE1	0.569	-0.069	1	0.577
ULK2	0.569	-0.108	2	0.427
SSTK	0.569	-0.045	4	0.633
MST4	0.569	-0.082	2	0.542
CHK2	0.568	-0.068	-3	0.233
SRPK3	0.568	-0.022	-3	0.281
NIM1	0.568	-0.045	3	0.454
PAK1	0.568	-0.054	-2	0.504
IRAK1	0.567	-0.164	-1	0.581
CAMK1D	0.567	-0.074	-3	0.259
CLK2	0.566	0.048	-3	0.293
P90RSK	0.566	-0.034	-3	0.340
MAPKAPK2	0.566	0.038	-3	0.323
ATM	0.566	-0.078	1	0.553
MNK2	0.566	0.004	-2	0.528
MLK4	0.565	-0.130	2	0.464
IKKE	0.565	-0.022	1	0.444
TTBK2	0.565	-0.092	2	0.432
KIS	0.565	0.201	1	0.634
DRAK1	0.565	-0.140	1	0.456
CAMK2A	0.565	-0.046	2	0.427
TBK1	0.564	-0.059	1	0.454
PKCH	0.564	-0.076	2	0.488
PAK3	0.564	-0.066	-2	0.523
SGK1	0.563	-0.063	-3	0.224
MARK2	0.563	-0.054	4	0.623
PKCI	0.563	-0.064	2	0.481
QIK	0.563	-0.096	-3	0.390
PLK3	0.563	-0.143	2	0.395
CAMK1A	0.563	-0.060	-3	0.251
IRE2	0.563	-0.100	2	0.433
PAK2	0.562	-0.098	-2	0.502
STK33	0.562	-0.111	2	0.324
PKCE	0.562	-0.047	2	0.523
CAMK2B	0.562	-0.068	2	0.387
QSK	0.562	-0.038	4	0.641
PKG2	0.562	-0.012	-2	0.453
NDR1	0.561	-0.008	-3	0.390
IKKB	0.561	-0.052	-2	0.570
WNK3	0.561	-0.197	1	0.547
PLK2	0.561	-0.091	-3	0.298
AURC	0.560	0.029	-2	0.417
MARK3	0.560	-0.038	4	0.629
AKT1	0.560	-0.054	-3	0.296
RSK3	0.560	-0.020	-3	0.322
GRK2	0.559	-0.112	-2	0.418
LATS2	0.559	0.075	-5	0.729
PKCG	0.559	-0.048	2	0.522
IKKA	0.559	0.021	-2	0.555
SRPK2	0.559	0.014	-3	0.254
NDR2	0.558	0.096	-3	0.437
CAMK4	0.558	-0.126	-3	0.356
GRK4	0.558	-0.092	-2	0.480
CAMK1G	0.557	-0.101	-3	0.301
PDHK3_TYR	0.557	0.184	4	0.669
MARK1	0.557	-0.085	4	0.629
AURB	0.557	-0.043	-2	0.415
MNK1	0.556	-0.041	-2	0.535
P70S6K	0.556	-0.058	-3	0.279
PKACG	0.555	-0.041	-2	0.499
PKACB	0.554	-0.012	-2	0.438
RIPK2	0.554	-0.210	1	0.431
PKCT	0.554	-0.079	2	0.480
ULK1	0.554	-0.116	-3	0.412
CK1D	0.554	-0.060	-3	0.218
PLK4	0.554	-0.088	2	0.280
MSK1	0.554	-0.063	-3	0.313
TGFBR2	0.553	-0.098	-2	0.424
RSK4	0.552	-0.036	-3	0.341
NUAK1	0.552	-0.060	-3	0.336
BCKDK	0.551	-0.101	-1	0.614
MSK2	0.550	-0.076	-3	0.315
SIK	0.549	-0.068	-3	0.314
ABL2	0.549	0.163	-1	0.640
TTBK1	0.549	-0.094	2	0.366
LIMK2_TYR	0.548	0.106	-3	0.461
YANK3	0.548	-0.075	2	0.200
PKN1	0.548	-0.076	-3	0.297
MAPKAPK5	0.547	-0.055	-3	0.274
FAM20C	0.547	-0.028	2	0.315
ABL1	0.547	0.158	-1	0.637
PKACA	0.546	-0.029	-2	0.401
GCN2	0.546	-0.079	2	0.430
CK1A2	0.546	-0.072	-3	0.209
PKMYT1_TYR	0.545	0.019	3	0.538
AKT3	0.544	-0.050	-3	0.251
PHKG1	0.544	-0.064	-3	0.369
EPHA6	0.544	0.042	-1	0.646
MAP2K4_TYR	0.543	-0.010	-1	0.672
TESK1_TYR	0.542	0.011	3	0.551
CK2A2	0.542	-0.051	1	0.482
CK1E	0.541	-0.068	-3	0.239
PDHK4_TYR	0.541	0.010	2	0.471
EPHB4	0.540	0.049	-1	0.620
JAK2	0.540	0.047	1	0.566
PAK5	0.539	-0.002	-2	0.435
YANK2	0.539	-0.088	2	0.213
SNRK	0.538	-0.176	2	0.315
MAP2K6_TYR	0.538	-0.092	-1	0.674
MAP2K7_TYR	0.537	-0.145	2	0.476
AURA	0.537	-0.061	-2	0.366
TNK2	0.537	0.018	3	0.478
GRK3	0.537	-0.104	-2	0.368
EPHA4	0.536	0.027	2	0.419
TYK2	0.535	-0.042	1	0.579
LIMK1_TYR	0.535	-0.050	2	0.484
PAK4	0.534	0.019	-2	0.420
BMPR2_TYR	0.534	-0.081	-1	0.646
CK2A1	0.533	-0.064	1	0.451
TNNI3K_TYR	0.533	0.025	1	0.585
RET	0.533	-0.054	1	0.580
MST1R	0.532	-0.034	3	0.517
PINK1_TYR	0.532	-0.149	1	0.622
EPHB3	0.531	0.018	-1	0.606
PRKX	0.531	-0.025	-3	0.290
EPHB1	0.531	-0.007	1	0.614
PDHK1_TYR	0.531	-0.142	-1	0.677
CSF1R	0.530	-0.023	3	0.498
TNK1	0.530	-0.009	3	0.483
PHKG2	0.530	-0.100	-3	0.336
BRSK2	0.530	-0.121	-3	0.360
DDR1	0.530	-0.099	4	0.613
TYRO3	0.530	-0.050	3	0.474
FER	0.529	-0.041	1	0.673
EPHB2	0.528	0.003	-1	0.606
JAK1	0.528	0.010	1	0.488
SRMS	0.527	-0.033	1	0.639
ROS1	0.527	-0.077	3	0.431
BRSK1	0.527	-0.119	-3	0.335
MERTK	0.526	-0.008	3	0.502
FGR	0.524	-0.061	1	0.611
AXL	0.523	-0.045	3	0.482
HCK	0.523	-0.056	-1	0.616
PTK2B	0.523	0.038	-1	0.589
TEK	0.522	-0.078	3	0.412
EPHA3	0.522	-0.031	2	0.387
FRK	0.522	-0.006	-1	0.645
EPHA7	0.521	-0.030	2	0.412
KIT	0.520	-0.076	3	0.499
FGFR1	0.520	-0.100	3	0.453
KDR	0.520	-0.094	3	0.453
FGFR2	0.520	-0.118	3	0.470
YES1	0.520	-0.096	-1	0.625
LCK	0.519	-0.048	-1	0.617
ITK	0.519	-0.042	-1	0.593
JAK3	0.518	-0.113	1	0.542
BLK	0.518	-0.052	-1	0.623
NEK10_TYR	0.518	-0.067	1	0.425
PDGFRA	0.517	-0.092	3	0.482
EPHA5	0.517	-0.015	2	0.395
FLT3	0.517	-0.121	3	0.475
TXK	0.517	-0.051	1	0.559
MET	0.516	-0.041	3	0.518
LTK	0.516	-0.084	3	0.446
MUSK	0.516	0.028	1	0.579
PKG1	0.516	-0.072	-2	0.379
PDGFRB	0.515	-0.124	3	0.484
EPHA1	0.515	-0.047	3	0.495
BTK	0.514	-0.101	-1	0.573
ALK	0.513	-0.094	3	0.406
NTRK1	0.513	-0.120	-1	0.613
ERBB2	0.512	-0.089	1	0.616
FYN	0.512	-0.065	-1	0.569
EPHA8	0.512	-0.038	-1	0.578
CK1G3	0.511	-0.097	-3	0.138
DDR2	0.511	-0.083	3	0.399
CSK	0.510	-0.078	2	0.417
BMX	0.510	-0.078	-1	0.515
EGFR	0.510	-0.024	1	0.582
MATK	0.510	-0.068	-1	0.574
SYK	0.510	-0.000	-1	0.565
FGFR3	0.510	-0.128	3	0.446
TEC	0.510	-0.084	-1	0.539
LYN	0.510	-0.074	3	0.423
WEE1_TYR	0.509	-0.111	-1	0.542
CK1G1	0.509	-0.087	-3	0.212
EPHA2	0.509	-0.022	-1	0.568
PTK6	0.509	-0.125	-1	0.548
NTRK3	0.508	-0.084	-1	0.572
INSRR	0.508	-0.189	3	0.411
PTK2	0.508	-0.043	-1	0.564
FLT4	0.507	-0.148	3	0.441
FLT1	0.505	-0.131	-1	0.640
NTRK2	0.504	-0.140	3	0.447
SRC	0.504	-0.089	-1	0.578
ZAP70	0.503	0.045	-1	0.496
ERBB4	0.503	-0.019	1	0.618
FGFR4	0.500	-0.099	-1	0.587
INSR	0.500	-0.151	3	0.404
CK1G2	0.495	-0.095	-3	0.173
FES	0.488	-0.102	-1	0.493
IGF1R	0.485	-0.157	3	0.363
CK1A	0.484	-0.089	-3	0.165