Motif 1111 (n=80)

Position-wise Probabilities
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uniprot genes site source protein function
A5A3E0 POTEF Y940 ochoa POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) None
A6NKT7 RGPD3 S1482 ochoa RanBP2-like and GRIP domain-containing protein 3 None
O00267 SUPT5H T1036 ochoa Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed:10075709, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed:10075709, PubMed:10199401, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed:16214896). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed:16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed:16214896). Following phosphorylation by CDK9, DSIF can also positively regulate transcriptional elongation (PubMed:16427012). Required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed:10393184, PubMed:10454543, PubMed:11809800, PubMed:9514752). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed:11112772, PubMed:14701750). {ECO:0000269|PubMed:10075709, ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10421630, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10757782, ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11112772, ECO:0000269|PubMed:11553615, ECO:0000269|PubMed:11809800, ECO:0000269|PubMed:12653964, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:14701750, ECO:0000269|PubMed:15136722, ECO:0000269|PubMed:15380072, ECO:0000269|PubMed:16214896, ECO:0000269|PubMed:16427012, ECO:0000269|PubMed:9450929, ECO:0000269|PubMed:9514752, ECO:0000269|PubMed:9857195}.
O00303 EIF3F T255 ochoa Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03005, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. {ECO:0000269|PubMed:21124883}.
O14715 RGPD8 S1481 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O15198 SMAD9 T324 ochoa Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
O15234 CASC3 T155 ochoa Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}.
O75469 NR1I2 T133 psp Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
O75469 NR1I2 T248 psp Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
P00367 GLUD1 T228 ochoa Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250|UniProtKB:P10860, ECO:0000269|PubMed:11032875, ECO:0000269|PubMed:11254391, ECO:0000269|PubMed:11297618, ECO:0000269|PubMed:16023112, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:9571255}.
P0DJD0 RGPD1 S1466 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 S1474 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P0DPH7 TUBA3C T223 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D T223 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P11166 SLC2A1 T234 ochoa Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter) Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:10227690, PubMed:10954735, PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:32860739). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P17809, ECO:0000250|UniProtKB:P46896, ECO:0000269|PubMed:10227690, ECO:0000269|PubMed:10954735, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:27078104, ECO:0000269|PubMed:32860739}.
P11169 SLC2A3 T232 ochoa Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:26176916, PubMed:9477959). Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P32037, ECO:0000269|PubMed:26176916, ECO:0000269|PubMed:32860739, ECO:0000269|PubMed:8457197, ECO:0000269|PubMed:9477959}.
P22090 RPS4Y1 T33 ochoa Small ribosomal subunit protein eS4, Y isoform 1 (40S ribosomal protein S4) None
P30305 CDC25B T404 psp M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978). {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:1836978, ECO:0000269|PubMed:20360007}.
P33981 TTK T594 psp Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
P35609 ACTN2 T178 ochoa Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
P35609 ACTN2 T308 ochoa Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
P49792 RANBP2 S2457 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P51153 RAB13 T49 ochoa Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}.
P55011 SLC12A2 T266 ochoa Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}.
P60709 ACTB Y240 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P62701 RPS4X T33 ochoa Small ribosomal subunit protein eS4, X isoform (40S ribosomal protein S4) (SCR10) (Single copy abundant mRNA protein) Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.
P62736 ACTA2 Y242 ochoa Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P63241 EIF5A T76 ochoa Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (PubMed:16987817). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (PubMed:15371445). Also regulates TNF-alpha-mediated apoptosis (PubMed:15452064, PubMed:17187778). Mediates effects of polyamines on neuronal process extension and survival (PubMed:17360499). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (PubMed:29712776). {ECO:0000250|UniProtKB:P23301, ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499, ECO:0000269|PubMed:29712776, ECO:0000269|PubMed:33547280}.; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:8253832}.
P63261 ACTG1 Y240 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P63267 ACTG2 Y241 ochoa Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68032 ACTC1 Y242 ochoa Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68104 EEF1A1 T22 ochoa Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}.
P68133 ACTA1 Y242 ochoa Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68363 TUBA1B T223 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
P68366 TUBA4A T223 ochoa Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78527 PRKDC T516 ochoa DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
Q05639 EEF1A2 T22 ochoa Elongation factor 1-alpha 2 (EF-1-alpha-2) (EC 3.6.5.-) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity). {ECO:0000250|UniProtKB:P68104, ECO:0000250|UniProtKB:Q71V39}.
Q08043 ACTN3 T185 ochoa Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Q13057 COASY T173 ochoa Bifunctional coenzyme A synthase (CoA synthase) (NBP) (POV-2) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:24360804}.
Q13203 MYBPH T183 ochoa Myosin-binding protein H (MyBP-H) (H-protein) Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
Q14324 MYBPC2 T849 ochoa Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Q15797 SMAD1 T322 ochoa|psp Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) Transcriptional modulator that plays a role in various cellular processes, including embryonic development, cell differentiation, and tissue homeostasis (PubMed:9335504). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:33667543). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33667543). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Positively regulates BMP4-induced expression of odontogenic development regulator MSX1 following IPO7-mediated nuclear import (By similarity). {ECO:0000250|UniProtKB:P70340, ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:33667543, ECO:0000269|PubMed:9335504}.
Q29RF7 PDS5A T1160 ochoa Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.
Q562R1 ACTBL2 Y241 ochoa Beta-actin-like protein 2 (Kappa-actin) Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}.
Q5VTE0 EEF1A1P5 T22 ochoa Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}.
Q6IS14 EIF5AL1 T76 ochoa Eukaryotic translation initiation factor 5A-1-like (eIF-5A-1-like) (eIF-5A1-like) (Eukaryotic initiation factor 5A isoform 1-like) Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241}.
Q6PEY2 TUBA3E T223 ochoa Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6S8J3 POTEE Y940 ochoa POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) None
Q71U36 TUBA1A T223 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q7Z3D4 LYSMD3 T54 ochoa LysM and putative peptidoglycan-binding domain-containing protein 3 Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}.
Q7Z3J3 RGPD4 S1482 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q8TDB8 SLC2A14 T256 ochoa Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14) Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane. {ECO:0000269|PubMed:28971850}.
Q96BK5 PINX1 T170 ochoa PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}.
Q96I24 FUBP3 T43 ochoa Far upstream element-binding protein 3 (FUSE-binding protein 3) May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.
Q99501 GAS2L1 T220 ochoa GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}.
Q99666 RGPD5 S1481 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q99717 SMAD5 T322 ochoa Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}.
Q9BQE3 TUBA1C T223 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BY89 KIAA1671 T1231 ochoa Uncharacterized protein KIAA1671 None
Q9BYX7 POTEKP Y240 ochoa Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K) None
Q9GZV4 EIF5A2 T76 ochoa Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:14622290). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:14622290}.
Q9H329 EPB41L4B T424 ochoa Band 4.1-like protein 4B (Erythrocyte membrane protein band 4.1-like 4B) (FERM-containing protein CG1) (Protein EHM2) Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927). {ECO:0000250|UniProtKB:Q9JMC8, ECO:0000269|PubMed:14521927, ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:23664528}.
Q9NRP7 STK36 T152 ochoa Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:28543983}.
Q9NY65 TUBA8 T223 ochoa Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9UL51 HCN2 T576 psp Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity). {ECO:0000250|UniProtKB:Q9JKA9, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219, ECO:0000269|PubMed:22006928}.
Q9UQR1 ZNF148 T632 ochoa Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89) Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
Q9Y4B5 MTCL1 T1747 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
P07900 HSP90AA1 T88 Sugiyama Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}.
P08238 HSP90AB1 T83 Sugiyama Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
Q58FG1 HSP90AA4P T28 Sugiyama Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad) Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
P30281 CCND3 T128 Sugiyama G1/S-specific cyclin-D3 Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}.
P15313 ATP6V1B1 T323 Sugiyama V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1) Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:16769747). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). Essential for the proper assembly and activity of V-ATPase (PubMed:16769747). In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (PubMed:16769747). Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity). {ECO:0000250|UniProtKB:Q91YH6, ECO:0000269|PubMed:16769747, ECO:0000303|PubMed:32001091}.
P21281 ATP6V1B2 T329 Sugiyama V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2) Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity). {ECO:0000250|UniProtKB:P62814, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}.
Q06187 BTK T602 Sugiyama Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}.
O15212 PFDN6 T75 Sugiyama Prefoldin subunit 6 (Protein Ke2) Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
Q13442 PDAP1 T92 Sugiyama 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. {ECO:0000250}.
Q5S007 LRRK2 T1849 EPSD|PSP Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}.
Q9Y5S2 CDC42BPB T858 Sugiyama Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250|UniProtKB:Q7TT50, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Q92630 DYRK2 T468 Sugiyama Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}.
Q96PY6 NEK1 T24 Sugiyama Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}.
Download
reactome_id name p -log10_p
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 2.486900e-14 13.604
R-HSA-190828 Gap junction trafficking 6.987744e-13 12.156
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.020184e-12 11.991
R-HSA-437239 Recycling pathway of L1 1.207590e-12 11.918
R-HSA-190872 Transport of connexons to the plasma membrane 1.449174e-12 11.839
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.929235e-12 11.715
R-HSA-157858 Gap junction trafficking and regulation 1.709966e-12 11.767
R-HSA-389977 Post-chaperonin tubulin folding pathway 2.797540e-12 11.553
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 1.175349e-11 10.930
R-HSA-9646399 Aggrephagy 1.073763e-11 10.969
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.256228e-11 10.901
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 1.547962e-11 10.810
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 2.780642e-11 10.556
R-HSA-9619483 Activation of AMPK downstream of NMDARs 3.140321e-11 10.503
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 9.195833e-11 10.036
R-HSA-190861 Gap junction assembly 1.359309e-10 9.867
R-HSA-390466 Chaperonin-mediated protein folding 2.620918e-10 9.582
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 4.707772e-10 9.327
R-HSA-391251 Protein folding 4.673690e-10 9.330
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 1.335861e-09 8.874
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 3.814851e-09 8.419
R-HSA-373760 L1CAM interactions 4.641846e-09 8.333
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 5.783399e-09 8.238
R-HSA-9612973 Autophagy 5.640399e-09 8.249
R-HSA-438064 Post NMDA receptor activation events 5.292913e-09 8.276
R-HSA-9663891 Selective autophagy 5.783399e-09 8.238
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 6.614864e-09 8.179
R-HSA-983189 Kinesins 6.866862e-09 8.163
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 2.121701e-08 7.673
R-HSA-5620920 Cargo trafficking to the periciliary membrane 2.165505e-08 7.664
R-HSA-69275 G2/M Transition 2.966303e-08 7.528
R-HSA-453274 Mitotic G2-G2/M phases 3.270193e-08 7.485
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 3.783694e-08 7.422
R-HSA-68877 Mitotic Prometaphase 4.154649e-08 7.381
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 4.923647e-08 7.308
R-HSA-9833482 PKR-mediated signaling 4.923647e-08 7.308
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 8.859315e-08 7.053
R-HSA-2467813 Separation of Sister Chromatids 1.054797e-07 6.977
R-HSA-422475 Axon guidance 1.344003e-07 6.872
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 2.154034e-07 6.667
R-HSA-6807878 COPI-mediated anterograde transport 2.154034e-07 6.667
R-HSA-9675108 Nervous system development 3.128371e-07 6.505
R-HSA-1632852 Macroautophagy 3.516827e-07 6.454
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 7.075548e-07 6.150
R-HSA-383280 Nuclear Receptor transcription pathway 7.299920e-07 6.137
R-HSA-5620924 Intraflagellar transport 9.763853e-07 6.010
R-HSA-68882 Mitotic Anaphase 1.103244e-06 5.957
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.145560e-06 5.941
R-HSA-2132295 MHC class II antigen presentation 1.353865e-06 5.868
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 1.887348e-06 5.724
R-HSA-8856688 Golgi-to-ER retrograde transport 2.386563e-06 5.622
R-HSA-9764561 Regulation of CDH1 Function 2.291546e-06 5.640
R-HSA-5617833 Cilium Assembly 3.441134e-06 5.463
R-HSA-390522 Striated Muscle Contraction 3.885419e-06 5.411
R-HSA-9609690 HCMV Early Events 4.317483e-06 5.365
R-HSA-199977 ER to Golgi Anterograde Transport 5.264442e-06 5.279
R-HSA-69278 Cell Cycle, Mitotic 6.309570e-06 5.200
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 7.913921e-06 5.102
R-HSA-3000171 Non-integrin membrane-ECM interactions 9.150629e-06 5.039
R-HSA-68886 M Phase 2.005665e-05 4.698
R-HSA-9609646 HCMV Infection 2.598009e-05 4.585
R-HSA-1852241 Organelle biogenesis and maintenance 2.620876e-05 4.582
R-HSA-156842 Eukaryotic Translation Elongation 2.890486e-05 4.539
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 3.948687e-05 4.404
R-HSA-948021 Transport to the Golgi and subsequent modification 4.207441e-05 4.376
R-HSA-5610787 Hedgehog 'off' state 4.607912e-05 4.336
R-HSA-1640170 Cell Cycle 6.796456e-05 4.168
R-HSA-2262752 Cellular responses to stress 7.667126e-05 4.115
R-HSA-1266738 Developmental Biology 8.202926e-05 4.086
R-HSA-9735869 SARS-CoV-1 modulates host translation machinery 9.820327e-05 4.008
R-HSA-112315 Transmission across Chemical Synapses 1.595252e-04 3.797
R-HSA-9824446 Viral Infection Pathways 2.532192e-04 3.597
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 2.792813e-04 3.554
R-HSA-5358351 Signaling by Hedgehog 2.796685e-04 3.553
R-HSA-8953897 Cellular responses to stimuli 3.036240e-04 3.518
R-HSA-9613829 Chaperone Mediated Autophagy 3.327265e-04 3.478
R-HSA-397014 Muscle contraction 3.877425e-04 3.411
R-HSA-72649 Translation initiation complex formation 4.687752e-04 3.329
R-HSA-112316 Neuronal System 4.964164e-04 3.304
R-HSA-913531 Interferon Signaling 5.244253e-04 3.280
R-HSA-72702 Ribosomal scanning and start codon recognition 5.276588e-04 3.278
R-HSA-189200 Cellular hexose transport 5.880709e-04 3.231
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 5.916238e-04 3.228
R-HSA-1500931 Cell-Cell communication 7.058286e-04 3.151
R-HSA-9764265 Regulation of CDH1 Expression and Function 8.541768e-04 3.068
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 8.541768e-04 3.068
R-HSA-201451 Signaling by BMP 9.431046e-04 3.025
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 1.517513e-03 2.819
R-HSA-199991 Membrane Trafficking 1.534730e-03 2.814
R-HSA-5336415 Uptake and function of diphtheria toxin 1.555385e-03 2.808
R-HSA-196025 Formation of annular gap junctions 1.875047e-03 2.727
R-HSA-3371511 HSF1 activation 2.002536e-03 2.698
R-HSA-392499 Metabolism of proteins 2.006961e-03 2.697
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 2.206031e-03 2.656
R-HSA-190873 Gap junction degradation 2.223202e-03 2.653
R-HSA-204626 Hypusine synthesis from eIF5A-lysine 2.223202e-03 2.653
R-HSA-9834752 Respiratory syncytial virus genome replication 2.223202e-03 2.653
R-HSA-156902 Peptide chain elongation 2.414164e-03 2.617
R-HSA-418990 Adherens junctions interactions 2.516483e-03 2.599
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 2.599522e-03 2.585
R-HSA-5653656 Vesicle-mediated transport 2.703722e-03 2.568
R-HSA-9856651 MITF-M-dependent gene expression 2.868138e-03 2.542
R-HSA-9705683 SARS-CoV-2-host interactions 3.079115e-03 2.512
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.248294e-03 2.488
R-HSA-72689 Formation of a pool of free 40S subunits 3.311775e-03 2.480
R-HSA-5663205 Infectious disease 3.433360e-03 2.464
R-HSA-9711097 Cellular response to starvation 3.493118e-03 2.457
R-HSA-446203 Asparagine N-linked glycosylation 3.935133e-03 2.405
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 5.121653e-03 2.291
R-HSA-927802 Nonsense-Mediated Decay (NMD) 5.739982e-03 2.241
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 5.739982e-03 2.241
R-HSA-399954 Sema3A PAK dependent Axon repulsion 5.430884e-03 2.265
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 5.121653e-03 2.291
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 5.137439e-03 2.289
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 5.553514e-03 2.255
R-HSA-168255 Influenza Infection 5.710614e-03 2.243
R-HSA-446353 Cell-extracellular matrix interactions 5.430884e-03 2.265
R-HSA-9692914 SARS-CoV-1-host interactions 4.829984e-03 2.316
R-HSA-421270 Cell-cell junction organization 4.725709e-03 2.326
R-HSA-109582 Hemostasis 6.238188e-03 2.205
R-HSA-72737 Cap-dependent Translation Initiation 6.757938e-03 2.170
R-HSA-72613 Eukaryotic Translation Initiation 6.757938e-03 2.170
R-HSA-446728 Cell junction organization 7.398533e-03 2.131
R-HSA-3371556 Cellular response to heat stress 7.692456e-03 2.114
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 8.039360e-03 2.095
R-HSA-380259 Loss of Nlp from mitotic centrosomes 8.039360e-03 2.095
R-HSA-8854518 AURKA Activation by TPX2 8.991543e-03 2.046
R-HSA-373753 Nephrin family interactions 9.196547e-03 2.036
R-HSA-196836 Vitamin C (ascorbate) metabolism 9.910392e-03 2.004
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 9.910392e-03 2.004
R-HSA-162582 Signal Transduction 1.041984e-02 1.982
R-HSA-9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 1.064809e-02 1.973
R-HSA-9730414 MITF-M-regulated melanocyte development 1.104239e-02 1.957
R-HSA-5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) 1.136211e-02 1.945
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 1.140935e-02 1.943
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.146109e-02 1.941
R-HSA-380287 Centrosome maturation 1.223138e-02 1.913
R-HSA-597592 Post-translational protein modification 1.387153e-02 1.858
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 1.468435e-02 1.833
R-HSA-72766 Translation 1.480021e-02 1.830
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 2.259651e-02 1.646
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 2.259651e-02 1.646
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 2.259651e-02 1.646
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 2.259651e-02 1.646
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 2.259651e-02 1.646
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 2.259651e-02 1.646
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 2.259651e-02 1.646
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 2.259651e-02 1.646
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 2.259651e-02 1.646
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 2.259651e-02 1.646
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 2.259651e-02 1.646
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 1.737424e-02 1.760
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 1.996703e-02 1.700
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2.048902e-02 1.688
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 1.945251e-02 1.711
R-HSA-445095 Interaction between L1 and Ankyrins 1.555919e-02 1.808
R-HSA-77387 Insulin receptor recycling 1.645591e-02 1.784
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 1.605994e-02 1.794
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 1.665584e-02 1.778
R-HSA-9679506 SARS-CoV Infections 1.745372e-02 1.758
R-HSA-9694516 SARS-CoV-2 Infection 1.939548e-02 1.712
R-HSA-1474244 Extracellular matrix organization 1.557291e-02 1.808
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 2.265189e-02 1.645
R-HSA-72764 Eukaryotic Translation Termination 2.321134e-02 1.634
R-HSA-917977 Transferrin endocytosis and recycling 2.438526e-02 1.613
R-HSA-9678108 SARS-CoV-1 Infection 2.550709e-02 1.593
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 2.656792e-02 1.576
R-HSA-2408557 Selenocysteine synthesis 2.672532e-02 1.573
R-HSA-192823 Viral mRNA Translation 2.795648e-02 1.554
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 2.858326e-02 1.544
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 2.882663e-02 1.540
R-HSA-3371568 Attenuation phase 2.998390e-02 1.523
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 3.116485e-02 1.506
R-HSA-74160 Gene expression (Transcription) 3.173674e-02 1.498
R-HSA-5674135 MAP2K and MAPK activation 3.235303e-02 1.490
R-HSA-9656223 Signaling by RAF1 mutants 3.235303e-02 1.490
R-HSA-1296061 HCN channels 3.370462e-02 1.472
R-HSA-9754119 Drug-mediated inhibition of CDK4/CDK6 activity 3.370462e-02 1.472
R-HSA-3928662 EPHB-mediated forward signaling 3.603964e-02 1.443
R-HSA-4420097 VEGFA-VEGFR2 Pathway 3.813658e-02 1.419
R-HSA-9649948 Signaling downstream of RAS mutants 3.858325e-02 1.414
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 3.858325e-02 1.414
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 3.858325e-02 1.414
R-HSA-6802949 Signaling by RAS mutants 3.858325e-02 1.414
R-HSA-376176 Signaling by ROBO receptors 3.885129e-02 1.411
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 3.988012e-02 1.399
R-HSA-8937144 Aryl hydrocarbon receptor signalling 4.468784e-02 1.350
R-HSA-3371571 HSF1-dependent transactivation 4.522948e-02 1.345
R-HSA-5339562 Uptake and actions of bacterial toxins 4.660618e-02 1.332
R-HSA-194138 Signaling by VEGF 4.664614e-02 1.331
R-HSA-1280215 Cytokine Signaling in Immune system 4.780490e-02 1.321
R-HSA-9639288 Amino acids regulate mTORC1 4.799819e-02 1.319
R-HSA-445355 Smooth Muscle Contraction 4.799819e-02 1.319
R-HSA-114608 Platelet degranulation 4.828618e-02 1.316
R-HSA-8857538 PTK6 promotes HIF1A stabilization 5.013306e-02 1.300
R-HSA-5653890 Lactose synthesis 5.013306e-02 1.300
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 5.226391e-02 1.282
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 5.424675e-02 1.266
R-HSA-2470946 Cohesin Loading onto Chromatin 5.554757e-02 1.255
R-HSA-426117 Cation-coupled Chloride cotransporters 5.554757e-02 1.255
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 7.160860e-02 1.145
R-HSA-390450 Folding of actin by CCT/TriC 7.160860e-02 1.145
R-HSA-3000484 Scavenging by Class F Receptors 8.739943e-02 1.058
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 9.260377e-02 1.033
R-HSA-8964315 G beta:gamma signalling through BTK 1.029245e-01 0.987
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 7.873548e-02 1.104
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 9.411674e-02 1.026
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 6.581988e-02 1.182
R-HSA-6802957 Oncogenic MAPK signaling 9.942331e-02 1.003
R-HSA-192905 vRNP Assembly 7.690201e-02 1.114
R-HSA-68884 Mitotic Telophase/Cytokinesis 8.216556e-02 1.085
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 8.739943e-02 1.058
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 9.260377e-02 1.033
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 9.260377e-02 1.033
R-HSA-9948299 Ribosome-associated quality control 5.962400e-02 1.225
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 7.160860e-02 1.145
R-HSA-196783 Coenzyme A biosynthesis 1.131292e-01 0.946
R-HSA-9664417 Leishmania phagocytosis 6.147039e-02 1.211
R-HSA-9664407 Parasite infection 6.147039e-02 1.211
R-HSA-9664422 FCGR3A-mediated phagocytosis 6.147039e-02 1.211
R-HSA-9924644 Developmental Lineages of the Mammary Gland 7.708001e-02 1.113
R-HSA-8876725 Protein methylation 1.029245e-01 0.987
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 9.777875e-02 1.010
R-HSA-3270619 IRF3-mediated induction of type I IFN 1.029245e-01 0.987
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.029245e-01 0.987
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 9.777875e-02 1.010
R-HSA-9659379 Sensory processing of sound 8.889690e-02 1.051
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 7.057347e-02 1.151
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 9.446785e-02 1.025
R-HSA-9658195 Leishmania infection 9.431102e-02 1.025
R-HSA-9824443 Parasitic Infection Pathways 9.431102e-02 1.025
R-HSA-1643685 Disease 8.167776e-02 1.088
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 6.428983e-02 1.192
R-HSA-9006936 Signaling by TGFB family members 8.241940e-02 1.084
R-HSA-917937 Iron uptake and transport 8.207979e-02 1.086
R-HSA-2408522 Selenoamino acid metabolism 8.671900e-02 1.062
R-HSA-163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 1.030070e-01 0.987
R-HSA-9679191 Potential therapeutics for SARS 7.209521e-02 1.142
R-HSA-9013694 Signaling by NOTCH4 8.040214e-02 1.095
R-HSA-373755 Semaphorin interactions 6.271380e-02 1.203
R-HSA-73857 RNA Polymerase II Transcription 6.220294e-02 1.206
R-HSA-168256 Immune System 1.079548e-01 0.967
R-HSA-8986944 Transcriptional Regulation by MECP2 1.121182e-01 0.950
R-HSA-1222556 ROS and RNS production in phagocytes 8.040214e-02 1.095
R-HSA-212436 Generic Transcription Pathway 6.299040e-02 1.201
R-HSA-8868773 rRNA processing in the nucleus and cytosol 1.156288e-01 0.937
R-HSA-74752 Signaling by Insulin receptor 1.158202e-01 0.936
R-HSA-2682334 EPH-Ephrin signaling 1.158202e-01 0.936
R-HSA-8953854 Metabolism of RNA 1.163878e-01 0.934
R-HSA-5637812 Signaling by EGFRvIII in Cancer 1.181884e-01 0.927
R-HSA-5637810 Constitutive Signaling by EGFRvIII 1.181884e-01 0.927
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 1.214310e-01 0.916
R-HSA-9665348 Signaling by ERBB2 ECD mutants 1.232190e-01 0.909
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 1.282212e-01 0.892
R-HSA-844456 The NLRP3 inflammasome 1.282212e-01 0.892
R-HSA-1834941 STING mediated induction of host immune responses 1.282212e-01 0.892
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 1.331952e-01 0.876
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1.381412e-01 0.860
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 1.381412e-01 0.860
R-HSA-5602498 MyD88 deficiency (TLR2/4) 1.381412e-01 0.860
R-HSA-6798695 Neutrophil degranulation 1.388111e-01 0.858
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 1.430592e-01 0.844
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 1.430592e-01 0.844
R-HSA-5603041 IRAK4 deficiency (TLR2/4) 1.430592e-01 0.844
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 1.430592e-01 0.844
R-HSA-168249 Innate Immune System 1.473230e-01 0.832
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 1.479495e-01 0.830
R-HSA-211000 Gene Silencing by RNA 1.484277e-01 0.828
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 1.504013e-01 0.823
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 1.528121e-01 0.816
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 1.528121e-01 0.816
R-HSA-1280218 Adaptive Immune System 1.557675e-01 0.808
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 1.576473e-01 0.802
R-HSA-429947 Deadenylation of mRNA 1.576473e-01 0.802
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 1.576473e-01 0.802
R-HSA-8863678 Neurodegenerative Diseases 1.576473e-01 0.802
R-HSA-5683057 MAPK family signaling cascades 1.587579e-01 0.799
R-HSA-9620244 Long-term potentiation 1.624552e-01 0.789
R-HSA-9932451 SWI/SNF chromatin remodelers 1.624552e-01 0.789
R-HSA-9932444 ATP-dependent chromatin remodelers 1.624552e-01 0.789
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 1.624552e-01 0.789
R-HSA-1643713 Signaling by EGFR in Cancer 1.672360e-01 0.777
R-HSA-8934593 Regulation of RUNX1 Expression and Activity 1.672360e-01 0.777
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 1.719898e-01 0.764
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 1.719898e-01 0.764
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 1.719898e-01 0.764
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 1.722789e-01 0.764
R-HSA-72312 rRNA processing 1.750874e-01 0.757
R-HSA-167287 HIV elongation arrest and recovery 1.767167e-01 0.753
R-HSA-167290 Pausing and recovery of HIV elongation 1.767167e-01 0.753
R-HSA-113418 Formation of the Early Elongation Complex 1.767167e-01 0.753
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 1.767167e-01 0.753
R-HSA-622312 Inflammasomes 1.767167e-01 0.753
R-HSA-196854 Metabolism of vitamins and cofactors 1.775137e-01 0.751
R-HSA-72086 mRNA Capping 1.814169e-01 0.741
R-HSA-9664565 Signaling by ERBB2 KD Mutants 1.814169e-01 0.741
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 1.860906e-01 0.730
R-HSA-1227990 Signaling by ERBB2 in Cancer 1.860906e-01 0.730
R-HSA-2424491 DAP12 signaling 1.860906e-01 0.730
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 1.860906e-01 0.730
R-HSA-8863795 Downregulation of ERBB2 signaling 1.860906e-01 0.730
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 1.860906e-01 0.730
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 1.907379e-01 0.720
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 1.907379e-01 0.720
R-HSA-9675126 Diseases of mitotic cell cycle 1.953589e-01 0.709
R-HSA-1855170 IPs transport between nucleus and cytosol 1.999539e-01 0.699
R-HSA-159227 Transport of the SLBP independent Mature mRNA 1.999539e-01 0.699
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 1.999539e-01 0.699
R-HSA-397795 G-protein beta:gamma signalling 1.999539e-01 0.699
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 1.999539e-01 0.699
R-HSA-5675482 Regulation of necroptotic cell death 1.999539e-01 0.699
R-HSA-9733709 Cardiogenesis 1.999539e-01 0.699
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.045228e-01 0.689
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.045228e-01 0.689
R-HSA-5696394 DNA Damage Recognition in GG-NER 2.045228e-01 0.689
R-HSA-8964539 Glutamate and glutamine metabolism 2.045228e-01 0.689
R-HSA-199220 Vitamin B5 (pantothenate) metabolism 2.045228e-01 0.689
R-HSA-9843745 Adipogenesis 2.053259e-01 0.688
R-HSA-203615 eNOS activation 2.090660e-01 0.680
R-HSA-180746 Nuclear import of Rev protein 2.090660e-01 0.680
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 2.135835e-01 0.670
R-HSA-425407 SLC-mediated transmembrane transport 2.170969e-01 0.663
R-HSA-9018519 Estrogen-dependent gene expression 2.178409e-01 0.662
R-HSA-8941326 RUNX2 regulates bone development 2.180755e-01 0.661
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 2.199338e-01 0.658
R-HSA-180910 Vpr-mediated nuclear import of PICs 2.225421e-01 0.653
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 2.269835e-01 0.644
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 2.269835e-01 0.644
R-HSA-5213460 RIPK1-mediated regulated necrosis 2.269835e-01 0.644
R-HSA-9958790 SLC-mediated transport of inorganic anions 2.269835e-01 0.644
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 2.313997e-01 0.636
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 2.313997e-01 0.636
R-HSA-168276 NS1 Mediated Effects on Host Pathways 2.313997e-01 0.636
R-HSA-162599 Late Phase of HIV Life Cycle 2.325256e-01 0.634
R-HSA-8856828 Clathrin-mediated endocytosis 2.346292e-01 0.630
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 2.357910e-01 0.627
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 2.357910e-01 0.627
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 2.357910e-01 0.627
R-HSA-167169 HIV Transcription Elongation 2.357910e-01 0.627
R-HSA-177243 Interactions of Rev with host cellular proteins 2.357910e-01 0.627
R-HSA-176033 Interactions of Vpr with host cellular proteins 2.357910e-01 0.627
R-HSA-5260271 Diseases of Immune System 2.357910e-01 0.627
R-HSA-5602358 Diseases associated with the TLR signaling cascade 2.357910e-01 0.627
R-HSA-9843743 Transcriptional regulation of brown and beige adipocyte differentiation 2.357910e-01 0.627
R-HSA-9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 2.357910e-01 0.627
R-HSA-76002 Platelet activation, signaling and aggregation 2.366359e-01 0.626
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 2.401575e-01 0.620
R-HSA-5218920 VEGFR2 mediated vascular permeability 2.401575e-01 0.620
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 2.401575e-01 0.620
R-HSA-69242 S Phase 2.451633e-01 0.611
R-HSA-69236 G1 Phase 2.573781e-01 0.589
R-HSA-69231 Cyclin D associated events in G1 2.573781e-01 0.589
R-HSA-2172127 DAP12 interactions 2.573781e-01 0.589
R-HSA-5673001 RAF/MAP kinase cascade 2.595101e-01 0.586
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 2.616225e-01 0.582
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 2.616225e-01 0.582
R-HSA-162587 HIV Life Cycle 2.641685e-01 0.578
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 2.658430e-01 0.575
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 2.658430e-01 0.575
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 2.658430e-01 0.575
R-HSA-9861718 Regulation of pyruvate metabolism 2.658430e-01 0.575
R-HSA-5684996 MAPK1/MAPK3 signaling 2.702904e-01 0.568
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 2.742125e-01 0.562
R-HSA-5619102 SLC transporter disorders 2.852967e-01 0.545
R-HSA-72187 mRNA 3'-end processing 2.906693e-01 0.537
R-HSA-112382 Formation of RNA Pol II elongation complex 2.906693e-01 0.537
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 2.906693e-01 0.537
R-HSA-75955 RNA Polymerase II Transcription Elongation 2.947255e-01 0.531
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 2.947255e-01 0.531
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 2.963108e-01 0.528
R-HSA-2980766 Nuclear Envelope Breakdown 3.107222e-01 0.508
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 3.107222e-01 0.508
R-HSA-194441 Metabolism of non-coding RNA 3.185854e-01 0.497
R-HSA-191859 snRNP Assembly 3.185854e-01 0.497
R-HSA-429914 Deadenylation-dependent mRNA decay 3.185854e-01 0.497
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 3.224837e-01 0.491
R-HSA-8873719 RAB geranylgeranylation 3.224837e-01 0.491
R-HSA-1227986 Signaling by ERBB2 3.224837e-01 0.491
R-HSA-168325 Viral Messenger RNA Synthesis 3.263599e-01 0.486
R-HSA-73856 RNA Polymerase II Transcription Termination 3.263599e-01 0.486
R-HSA-6784531 tRNA processing in the nucleus 3.302142e-01 0.481
R-HSA-983712 Ion channel transport 3.335984e-01 0.477
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 3.340466e-01 0.476
R-HSA-8848021 Signaling by PTK6 3.340466e-01 0.476
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 3.378574e-01 0.471
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 3.398424e-01 0.469
R-HSA-167172 Transcription of the HIV genome 3.528859e-01 0.452
R-HSA-5218859 Regulated Necrosis 3.528859e-01 0.452
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 3.602732e-01 0.443
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 3.639355e-01 0.439
R-HSA-8978934 Metabolism of cofactors 3.639355e-01 0.439
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 3.669370e-01 0.435
R-HSA-5578749 Transcriptional regulation by small RNAs 3.675770e-01 0.435
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 3.675770e-01 0.435
R-HSA-674695 RNA Polymerase II Pre-transcription Events 3.747983e-01 0.426
R-HSA-8852135 Protein ubiquitination 3.783784e-01 0.422
R-HSA-1169408 ISG15 antiviral mechanism 3.783784e-01 0.422
R-HSA-5689603 UCH proteinases 3.819381e-01 0.418
R-HSA-416482 G alpha (12/13) signalling events 3.889972e-01 0.410
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 3.889972e-01 0.410
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 3.994366e-01 0.399
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 4.096995e-01 0.388
R-HSA-5687128 MAPK6/MAPK4 signaling 4.130818e-01 0.384
R-HSA-162906 HIV Infection 4.131079e-01 0.384
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 4.164449e-01 0.380
R-HSA-141424 Amplification of signal from the kinetochores 4.164449e-01 0.380
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 4.164449e-01 0.380
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 4.197889e-01 0.377
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 4.197889e-01 0.377
R-HSA-70268 Pyruvate metabolism 4.231140e-01 0.374
R-HSA-9645723 Diseases of programmed cell death 4.264203e-01 0.370
R-HSA-1236974 ER-Phagosome pathway 4.297077e-01 0.367
R-HSA-8939211 ESR-mediated signaling 4.327814e-01 0.364
R-HSA-157118 Signaling by NOTCH 4.386165e-01 0.358
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 4.458677e-01 0.351
R-HSA-9837999 Mitochondrial protein degradation 4.490449e-01 0.348
R-HSA-5619115 Disorders of transmembrane transporters 4.521063e-01 0.345
R-HSA-1296071 Potassium Channels 4.584689e-01 0.339
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 4.584689e-01 0.339
R-HSA-422356 Regulation of insulin secretion 4.646627e-01 0.333
R-HSA-5688426 Deubiquitination 4.673003e-01 0.330
R-HSA-3214847 HATs acetylate histones 4.677333e-01 0.330
R-HSA-69618 Mitotic Spindle Checkpoint 4.707865e-01 0.327
R-HSA-70171 Glycolysis 4.707865e-01 0.327
R-HSA-9009391 Extra-nuclear estrogen signaling 4.738224e-01 0.324
R-HSA-9842860 Regulation of endogenous retroelements 4.768410e-01 0.322
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 4.768410e-01 0.322
R-HSA-9734767 Developmental Cell Lineages 4.822473e-01 0.317
R-HSA-5696398 Nucleotide Excision Repair 4.887451e-01 0.311
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 4.945964e-01 0.306
R-HSA-9700206 Signaling by ALK in cancer 4.945964e-01 0.306
R-HSA-1236975 Antigen processing-Cross presentation 4.974971e-01 0.303
R-HSA-71291 Metabolism of amino acids and derivatives 4.982943e-01 0.303
R-HSA-1483249 Inositol phosphate metabolism 5.089362e-01 0.293
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 5.113677e-01 0.291
R-HSA-382551 Transport of small molecules 5.130417e-01 0.290
R-HSA-2871809 FCERI mediated Ca+2 mobilization 5.228734e-01 0.282
R-HSA-3700989 Transcriptional Regulation by TP53 5.278130e-01 0.278
R-HSA-1592230 Mitochondrial biogenesis 5.283381e-01 0.277
R-HSA-70326 Glucose metabolism 5.283381e-01 0.277
R-HSA-9007101 Rab regulation of trafficking 5.283381e-01 0.277
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 5.337409e-01 0.273
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 5.337409e-01 0.273
R-HSA-8878166 Transcriptional regulation by RUNX2 5.337409e-01 0.273
R-HSA-68875 Mitotic Prophase 5.364193e-01 0.270
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 5.417305e-01 0.266
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 5.417305e-01 0.266
R-HSA-9816359 Maternal to zygotic transition (MZT) 5.443635e-01 0.264
R-HSA-162909 Host Interactions of HIV factors 5.469815e-01 0.262
R-HSA-163685 Integration of energy metabolism 5.845122e-01 0.233
R-HSA-453279 Mitotic G1 phase and G1/S transition 6.100638e-01 0.215
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 6.145396e-01 0.211
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 6.189646e-01 0.208
R-HSA-5693532 DNA Double-Strand Break Repair 6.255081e-01 0.204
R-HSA-9610379 HCMV Late Events 6.340601e-01 0.198
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 6.361677e-01 0.196
R-HSA-5633007 Regulation of TP53 Activity 6.403471e-01 0.194
R-HSA-73894 DNA Repair 6.417715e-01 0.193
R-HSA-9006931 Signaling by Nuclear Receptors 6.460420e-01 0.190
R-HSA-72306 tRNA processing 6.624986e-01 0.179
R-HSA-5689880 Ub-specific processing proteases 6.683020e-01 0.175
R-HSA-9824439 Bacterial Infection Pathways 6.840004e-01 0.165
R-HSA-168898 Toll-like Receptor Cascades 7.011066e-01 0.154
R-HSA-72163 mRNA Splicing - Major Pathway 7.062529e-01 0.151
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 7.211717e-01 0.142
R-HSA-72172 mRNA Splicing 7.243838e-01 0.140
R-HSA-5357801 Programmed Cell Death 7.259761e-01 0.139
R-HSA-8878171 Transcriptional regulation by RUNX1 7.573896e-01 0.121
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 7.594634e-01 0.119
R-HSA-3247509 Chromatin modifying enzymes 7.683957e-01 0.114
R-HSA-4839726 Chromatin organization 7.877176e-01 0.104
R-HSA-69620 Cell Cycle Checkpoints 7.985361e-01 0.098
R-HSA-416476 G alpha (q) signalling events 8.054436e-01 0.094
R-HSA-211945 Phase I - Functionalization of compounds 8.206633e-01 0.086
R-HSA-212165 Epigenetic regulation of gene expression 8.620421e-01 0.064
R-HSA-1428517 Aerobic respiration and respiratory electron transport 8.758100e-01 0.058
R-HSA-449147 Signaling by Interleukins 8.879564e-01 0.052
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.034398e-01 0.044
R-HSA-211859 Biological oxidations 9.576465e-01 0.019
R-HSA-388396 GPCR downstream signalling 9.905142e-01 0.004
R-HSA-372790 Signaling by GPCR 9.942476e-01 0.003
R-HSA-9709957 Sensory Perception 9.950540e-01 0.002
R-HSA-1430728 Metabolism 9.981563e-01 0.001
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
DMPK1DMPK1 0.748 0.230 -3 0.643
GAKGAK 0.744 0.066 1 0.773
DAPK2DAPK2 0.743 0.199 -3 0.714
CAMLCKCAMLCK 0.741 0.218 -2 0.817
DAPK3DAPK3 0.740 0.217 -3 0.662
LATS1LATS1 0.739 0.131 -3 0.677
CLK3CLK3 0.738 0.269 1 0.771
SMMLCKSMMLCK 0.737 0.193 -3 0.690
NIKNIK 0.735 0.042 -3 0.716
DAPK1DAPK1 0.734 0.231 -3 0.659
MOSMOS 0.734 0.195 1 0.842
PASKPASK 0.734 0.121 -3 0.701
PKRPKR 0.734 -0.040 1 0.709
VRK2VRK2 0.733 -0.139 1 0.764
GCKGCK 0.733 0.004 1 0.720
ROCK2ROCK2 0.733 0.159 -3 0.643
CAMK1BCAMK1B 0.732 0.138 -3 0.724
TAK1TAK1 0.732 -0.039 1 0.741
ALK2ALK2 0.732 0.114 -2 0.607
ALK4ALK4 0.731 0.062 -2 0.625
BMPR2BMPR2 0.731 -0.052 -2 0.671
MEK1MEK1 0.730 -0.069 2 0.637
TNIKTNIK 0.730 -0.009 3 0.849
KHS2KHS2 0.729 0.040 1 0.692
TAO2TAO2 0.729 -0.051 2 0.636
KHS1KHS1 0.729 0.004 1 0.675
HPK1HPK1 0.729 0.023 1 0.696
EEF2KEEF2K 0.729 0.016 3 0.822
ICKICK 0.729 0.087 -3 0.709
MRCKAMRCKA 0.728 0.182 -3 0.626
CDKL1CDKL1 0.728 0.070 -3 0.702
LRRK2LRRK2 0.727 -0.111 2 0.630
MINKMINK 0.727 -0.053 1 0.688
HGKHGK 0.726 -0.042 3 0.854
ROCK1ROCK1 0.726 0.173 -3 0.629
CLK4CLK4 0.726 0.217 -3 0.660
ACVR2BACVR2B 0.726 0.139 -2 0.592
SKMLCKSKMLCK 0.725 0.173 -2 0.781
PRPKPRPK 0.725 -0.054 -1 0.627
BRAFBRAF 0.725 -0.091 -4 0.675
TGFBR1TGFBR1 0.725 0.094 -2 0.591
ALPHAK3ALPHAK3 0.725 0.027 -1 0.573
NLKNLK 0.725 0.016 1 0.736
PIM2PIM2 0.725 0.122 -3 0.640
MST1MST1 0.724 -0.071 1 0.707
TAO3TAO3 0.724 -0.043 1 0.726
PBKPBK 0.724 -0.003 1 0.678
DLKDLK 0.724 -0.040 1 0.785
ASK1ASK1 0.724 -0.108 1 0.704
MRCKBMRCKB 0.724 0.181 -3 0.619
BMPR1BBMPR1B 0.724 0.136 1 0.837
MST3MST3 0.723 -0.013 2 0.629
AURBAURB 0.723 0.285 -2 0.840
MEK5MEK5 0.722 -0.157 2 0.617
ACVR2AACVR2A 0.722 0.091 -2 0.587
LOKLOK 0.722 -0.007 -2 0.714
BIKEBIKE 0.722 -0.000 1 0.655
MAP3K15MAP3K15 0.722 -0.114 1 0.697
PDK1PDK1 0.721 -0.067 1 0.674
CLK2CLK2 0.721 0.273 -3 0.643
PIM1PIM1 0.721 0.115 -3 0.665
MST2MST2 0.721 -0.079 1 0.734
VRK1VRK1 0.720 -0.152 2 0.603
NEK1NEK1 0.720 -0.142 1 0.673
BMPR1ABMPR1A 0.719 0.142 1 0.839
PIM3PIM3 0.719 0.120 -3 0.691
MYLK4MYLK4 0.719 0.229 -2 0.824
P70S6KBP70S6KB 0.719 0.139 -3 0.671
PKCDPKCD 0.718 0.101 2 0.594
MYO3BMYO3B 0.718 -0.046 2 0.613
YSK4YSK4 0.717 -0.088 1 0.715
TTKTTK 0.717 -0.061 -2 0.627
CAMKK1CAMKK1 0.717 -0.145 -2 0.599
RAF1RAF1 0.717 -0.006 1 0.778
ATRATR 0.717 -0.019 1 0.715
CRIKCRIK 0.717 0.118 -3 0.604
MEKK6MEKK6 0.717 -0.123 1 0.698
MYO3AMYO3A 0.716 -0.060 1 0.655
MEK2MEK2 0.716 -0.173 2 0.593
AKT2AKT2 0.716 0.176 -3 0.602
LKB1LKB1 0.716 -0.128 -3 0.638
AURCAURC 0.716 0.301 -2 0.842
HASPINHASPIN 0.716 0.051 -1 0.604
CAMKK2CAMKK2 0.716 -0.146 -2 0.627
GRK6GRK6 0.715 0.071 1 0.861
HIPK1HIPK1 0.715 0.080 1 0.596
MEKK2MEKK2 0.715 -0.152 2 0.577
SLKSLK 0.715 -0.010 -2 0.634
YSK1YSK1 0.715 -0.095 2 0.582
MSK1MSK1 0.715 0.239 -3 0.635
NEK11NEK11 0.715 -0.126 1 0.710
MPSK1MPSK1 0.714 -0.059 1 0.660
ANKRD3ANKRD3 0.714 -0.130 1 0.744
MEKK1MEKK1 0.714 -0.156 1 0.718
RSK2RSK2 0.714 0.170 -3 0.671
OSR1OSR1 0.714 -0.055 2 0.584
PKACBPKACB 0.714 0.276 -2 0.845
AURAAURA 0.713 0.286 -2 0.813
CHAK2CHAK2 0.713 0.005 -1 0.617
CLK1CLK1 0.713 0.174 -3 0.644
NEK8NEK8 0.713 -0.120 2 0.604
PKN3PKN3 0.712 0.055 -3 0.681
PRP4PRP4 0.712 -0.011 -3 0.641
SGK3SGK3 0.712 0.146 -3 0.629
MEKK3MEKK3 0.712 -0.081 1 0.717
MAKMAK 0.712 0.090 -2 0.698
CAMK2GCAMK2G 0.711 -0.001 2 0.652
SGK1SGK1 0.711 0.155 -3 0.548
AAK1AAK1 0.710 0.014 1 0.552
AKT1AKT1 0.710 0.187 -3 0.598
MST4MST4 0.710 0.049 2 0.655
NEK4NEK4 0.710 -0.171 1 0.660
CDC7CDC7 0.710 0.076 1 0.847
GRK7GRK7 0.710 0.061 1 0.828
ZAKZAK 0.710 -0.149 1 0.727
COTCOT 0.709 0.090 2 0.657
DYRK3DYRK3 0.709 0.150 1 0.582
TSSK2TSSK2 0.709 0.013 -5 0.676
PKACGPKACG 0.709 0.216 -2 0.849
RSK4RSK4 0.709 0.185 -3 0.639
NEK5NEK5 0.709 -0.213 1 0.689
SRPK1SRPK1 0.709 0.134 -3 0.661
P90RSKP90RSK 0.708 0.114 -3 0.672
PLK1PLK1 0.708 -0.019 -2 0.641
JNK2JNK2 0.707 -0.002 1 0.547
PKN2PKN2 0.707 0.080 -3 0.680
PAK2PAK2 0.707 0.163 -2 0.814
GRK5GRK5 0.707 -0.054 -3 0.691
PKG2PKG2 0.707 0.234 -2 0.851
P38AP38A 0.707 -0.014 1 0.593
BUB1BUB1 0.707 0.041 -5 0.598
CDKL5CDKL5 0.707 0.039 -3 0.693
TAO1TAO1 0.707 -0.084 1 0.634
GRK1GRK1 0.707 0.155 -2 0.571
CDK14CDK14 0.707 0.043 1 0.582
NDR1NDR1 0.706 0.116 -3 0.683
SRPK3SRPK3 0.706 0.109 -3 0.648
PAK1PAK1 0.706 0.175 -2 0.817
DYRK2DYRK2 0.706 0.063 1 0.575
MNK1MNK1 0.705 0.166 -2 0.835
AMPKA1AMPKA1 0.705 0.001 -3 0.684
DRAK1DRAK1 0.705 0.041 1 0.735
PERKPERK 0.705 -0.153 -2 0.628
WNK1WNK1 0.705 -0.007 -2 0.704
MSK2MSK2 0.705 0.171 -3 0.643
MLK2MLK2 0.705 -0.177 2 0.603
DYRK1ADYRK1A 0.704 0.060 1 0.630
JNK3JNK3 0.704 -0.018 1 0.583
CAMK4CAMK4 0.704 0.093 -3 0.663
HIPK3HIPK3 0.703 0.055 1 0.578
HRIHRI 0.703 -0.162 -2 0.646
MASTLMASTL 0.703 -0.195 -2 0.639
PKACAPKACA 0.703 0.252 -2 0.833
DCAMKL1DCAMKL1 0.702 -0.013 -3 0.642
P38BP38B 0.702 -0.011 1 0.549
PRKXPRKX 0.702 0.279 -3 0.563
PDHK4PDHK4 0.702 -0.217 1 0.772
NUAK2NUAK2 0.702 -0.001 -3 0.685
MLK1MLK1 0.702 -0.094 2 0.601
TSSK1TSSK1 0.702 0.009 -3 0.696
WNK4WNK4 0.702 -0.113 -2 0.685
PLK3PLK3 0.701 0.013 2 0.614
ERK5ERK5 0.701 -0.081 1 0.671
CDK5CDK5 0.701 0.013 1 0.617
CHK1CHK1 0.701 -0.063 -3 0.669
RIPK3RIPK3 0.700 -0.010 3 0.659
DCAMKL2DCAMKL2 0.700 -0.020 -3 0.664
NEK2NEK2 0.700 -0.104 2 0.584
STLK3STLK3 0.700 -0.175 1 0.690
CDK10CDK10 0.700 0.077 1 0.558
MOKMOK 0.700 0.037 1 0.564
RIPK1RIPK1 0.700 -0.101 1 0.670
MTORMTOR 0.699 -0.051 1 0.718
PKCAPKCA 0.699 0.045 2 0.539
PINK1PINK1 0.699 -0.099 1 0.701
TGFBR2TGFBR2 0.699 -0.034 -2 0.625
PKCEPKCE 0.699 0.106 2 0.522
CDK4CDK4 0.698 0.013 1 0.539
GRK2GRK2 0.698 0.005 -2 0.514
MARK4MARK4 0.698 -0.028 4 0.677
CAMK1DCAMK1D 0.698 0.069 -3 0.571
RSK3RSK3 0.698 0.125 -3 0.668
CDK1CDK1 0.697 0.029 1 0.580
MLK3MLK3 0.697 -0.047 2 0.551
PAK3PAK3 0.697 0.131 -2 0.811
IRAK4IRAK4 0.697 -0.134 1 0.635
DYRK1BDYRK1B 0.697 0.052 1 0.554
IRE2IRE2 0.697 -0.029 2 0.552
PDHK1PDHK1 0.697 -0.219 1 0.766
PKCHPKCH 0.696 0.035 2 0.519
AMPKA2AMPKA2 0.696 0.004 -3 0.665
DSTYKDSTYK 0.696 -0.072 2 0.677
AKT3AKT3 0.696 0.175 -3 0.559
MLK4MLK4 0.696 -0.067 2 0.539
PLK2PLK2 0.696 0.108 -3 0.803
CHAK1CHAK1 0.696 -0.087 2 0.542
CHK2CHK2 0.696 0.050 -3 0.563
CDK6CDK6 0.695 0.012 1 0.548
DYRK4DYRK4 0.695 0.086 1 0.527
ERK2ERK2 0.695 -0.041 1 0.566
HIPK4HIPK4 0.695 0.045 1 0.643
SSTKSSTK 0.695 0.032 4 0.621
P70S6KP70S6K 0.695 0.082 -3 0.613
MNK2MNK2 0.694 0.146 -2 0.830
NDR2NDR2 0.694 0.108 -3 0.674
PKCGPKCG 0.694 0.052 2 0.541
GSK3BGSK3B 0.694 -0.017 4 0.377
CAMK2DCAMK2D 0.694 -0.063 -3 0.676
PRKD3PRKD3 0.693 0.053 -3 0.635
NEK9NEK9 0.693 -0.247 2 0.594
WNK3WNK3 0.693 -0.128 1 0.709
PKCIPKCI 0.693 0.059 2 0.533
CAMK2BCAMK2B 0.693 0.018 2 0.636
SRPK2SRPK2 0.693 0.117 -3 0.611
PKCZPKCZ 0.693 -0.006 2 0.559
LATS2LATS2 0.692 0.047 -5 0.724
P38GP38G 0.692 -0.012 1 0.496
DNAPKDNAPK 0.692 -0.055 1 0.572
HUNKHUNK 0.692 -0.080 2 0.588
CDK13CDK13 0.692 0.006 1 0.571
PRKD2PRKD2 0.692 0.090 -3 0.642
HIPK2HIPK2 0.691 0.073 1 0.496
CAMK1GCAMK1G 0.691 0.057 -3 0.646
CAMK2ACAMK2A 0.691 0.028 2 0.658
MELKMELK 0.691 -0.030 -3 0.653
TLK2TLK2 0.691 -0.153 1 0.679
TBK1TBK1 0.691 -0.100 1 0.674
CDK12CDK12 0.690 0.011 1 0.542
PDHK3_TYRPDHK3_TYR 0.690 0.135 4 0.722
PKCBPKCB 0.690 0.012 2 0.542
CDK2CDK2 0.690 -0.011 1 0.690
MAPKAPK3MAPKAPK3 0.690 0.006 -3 0.630
SBKSBK 0.690 0.056 -3 0.521
ERK7ERK7 0.690 -0.039 2 0.393
QSKQSK 0.689 0.025 4 0.656
IRE1IRE1 0.689 -0.080 1 0.633
PKCTPKCT 0.689 0.050 2 0.529
GSK3AGSK3A 0.689 -0.009 4 0.391
CDK16CDK16 0.689 0.003 1 0.528
ULK2ULK2 0.688 -0.183 2 0.570
ERK1ERK1 0.688 -0.020 1 0.524
IKKEIKKE 0.688 -0.081 1 0.676
CAMK1ACAMK1A 0.688 0.079 -3 0.576
NEK3NEK3 0.687 -0.216 1 0.632
QIKQIK 0.687 -0.058 -3 0.663
PRKD1PRKD1 0.687 0.018 -3 0.680
NIM1NIM1 0.687 -0.065 3 0.710
IRAK1IRAK1 0.686 -0.184 -1 0.541
RIPK2RIPK2 0.686 -0.127 1 0.665
MARK3MARK3 0.686 0.011 4 0.645
TLK1TLK1 0.686 -0.169 -2 0.585
TESK1_TYRTESK1_TYR 0.686 0.056 3 0.810
EPHA6EPHA6 0.685 0.194 -1 0.619
ATMATM 0.685 -0.051 1 0.660
P38DP38D 0.685 -0.009 1 0.477
IKKBIKKB 0.685 -0.049 -2 0.556
BMPR2_TYRBMPR2_TYR 0.685 0.212 -1 0.676
PDHK4_TYRPDHK4_TYR 0.684 0.123 2 0.722
MARK1MARK1 0.684 -0.024 4 0.652
CDK3CDK3 0.684 0.024 1 0.526
CDK17CDK17 0.684 -0.014 1 0.510
MARK2MARK2 0.684 -0.032 4 0.605
MAP2K6_TYRMAP2K6_TYR 0.683 0.106 -1 0.636
MAPKAPK2MAPKAPK2 0.683 0.061 -3 0.617
NEK6NEK6 0.683 -0.113 -2 0.641
NEK7NEK7 0.682 -0.199 -3 0.670
CDK9CDK9 0.682 -0.033 1 0.571
PINK1_TYRPINK1_TYR 0.681 0.051 1 0.770
JNK1JNK1 0.681 -0.033 1 0.570
CDK7CDK7 0.681 -0.033 1 0.599
PAK6PAK6 0.681 0.164 -2 0.813
MAP2K4_TYRMAP2K4_TYR 0.680 0.009 -1 0.624
MAP2K7_TYRMAP2K7_TYR 0.680 -0.016 2 0.671
CDK18CDK18 0.679 -0.014 1 0.539
GCN2GCN2 0.679 -0.098 2 0.594
PKMYT1_TYRPKMYT1_TYR 0.679 -0.048 3 0.778
CDK8CDK8 0.678 -0.029 1 0.593
STK33STK33 0.678 -0.112 2 0.445
NUAK1NUAK1 0.678 -0.028 -3 0.649
LIMK2_TYRLIMK2_TYR 0.677 -0.014 -3 0.707
SMG1SMG1 0.677 -0.138 1 0.645
PDHK1_TYRPDHK1_TYR 0.677 0.060 -1 0.647
SNRKSNRK 0.676 -0.043 2 0.540
TXKTXK 0.676 0.145 1 0.835
GRK4GRK4 0.676 -0.112 -2 0.583
EPHA4EPHA4 0.675 0.106 2 0.640
SIKSIK 0.675 -0.012 -3 0.628
PKN1PKN1 0.674 0.032 -3 0.615
ULK1ULK1 0.674 -0.169 -3 0.649
IKKAIKKA 0.673 -0.042 -2 0.515
PHKG2PHKG2 0.673 0.013 -3 0.655
GRK3GRK3 0.673 -0.006 -2 0.469
EPHB4EPHB4 0.673 0.075 -1 0.558
PHKG1PHKG1 0.672 -0.063 -3 0.667
FERFER 0.672 0.039 1 0.852
INSRRINSRR 0.672 0.054 3 0.700
YANK3YANK3 0.672 -0.029 2 0.309
RETRET 0.672 -0.010 1 0.726
PLK4PLK4 0.672 -0.147 2 0.473
TTBK2TTBK2 0.671 -0.207 2 0.472
LIMK1_TYRLIMK1_TYR 0.671 -0.108 2 0.640
LCKLCK 0.670 0.135 -1 0.627
YES1YES1 0.670 0.048 -1 0.594
PKG1PKG1 0.670 0.190 -2 0.824
SRMSSRMS 0.670 0.071 1 0.850
TYK2TYK2 0.670 -0.087 1 0.723
TYRO3TYRO3 0.670 -0.064 3 0.778
MST1RMST1R 0.669 -0.039 3 0.768
CSF1RCSF1R 0.669 -0.008 3 0.761
CDK19CDK19 0.669 -0.016 1 0.553
FYNFYN 0.669 0.191 -1 0.651
ROS1ROS1 0.668 -0.066 3 0.741
PTK2PTK2 0.668 0.206 -1 0.652
HCKHCK 0.668 0.074 -1 0.608
PAK5PAK5 0.667 0.155 -2 0.788
JAK3JAK3 0.667 0.023 1 0.714
CK1DCK1D 0.667 -0.021 -3 0.410
KITKIT 0.667 0.019 3 0.759
CK2A2CK2A2 0.667 0.046 1 0.768
FGFR2FGFR2 0.666 0.004 3 0.703
EPHB1EPHB1 0.666 0.054 1 0.825
EPHB2EPHB2 0.666 0.083 -1 0.537
BRSK1BRSK1 0.666 -0.023 -3 0.646
FLT3FLT3 0.666 -0.014 3 0.779
BCKDKBCKDK 0.666 -0.192 -1 0.527
BMXBMX 0.666 0.063 -1 0.539
JAK2JAK2 0.665 -0.091 1 0.718
ITKITK 0.665 0.050 -1 0.571
DDR1DDR1 0.665 -0.084 4 0.629
MAPKAPK5MAPKAPK5 0.665 -0.046 -3 0.613
TEKTEK 0.665 -0.019 3 0.697
CK1A2CK1A2 0.664 -0.002 -3 0.418
EPHB3EPHB3 0.664 0.032 -1 0.536
BLKBLK 0.664 0.116 -1 0.621
TECTEC 0.663 0.003 -1 0.501
EPHA7EPHA7 0.663 0.070 2 0.626
TNK1TNK1 0.663 -0.054 3 0.755
BRSK2BRSK2 0.663 -0.081 -3 0.649
PDGFRBPDGFRB 0.662 -0.083 3 0.776
ABL2ABL2 0.662 -0.011 -1 0.563
SYKSYK 0.661 0.194 -1 0.623
KDRKDR 0.661 -0.002 3 0.701
NEK10_TYRNEK10_TYR 0.661 -0.070 1 0.609
CK1ECK1E 0.661 -0.014 -3 0.468
CK2A1CK2A1 0.661 0.040 1 0.751
FRKFRK 0.661 0.080 -1 0.590
EPHA8EPHA8 0.660 0.115 -1 0.578
EPHA5EPHA5 0.660 0.080 2 0.638
FGRFGR 0.660 -0.054 1 0.790
FLT1FLT1 0.659 0.047 -1 0.606
BTKBTK 0.659 -0.049 -1 0.526
MERTKMERTK 0.659 -0.026 3 0.705
ALKALK 0.659 -0.044 3 0.699
FGFR3FGFR3 0.659 0.013 3 0.681
WEE1_TYRWEE1_TYR 0.659 -0.024 -1 0.548
FAM20CFAM20C 0.659 0.009 2 0.506
PDGFRAPDGFRA 0.658 -0.107 3 0.783
PTK2BPTK2B 0.658 0.012 -1 0.520
AXLAXL 0.658 -0.088 3 0.707
EPHA1EPHA1 0.658 -0.000 3 0.730
LTKLTK 0.658 -0.051 3 0.694
ERBB2ERBB2 0.658 0.013 1 0.795
PAK4PAK4 0.658 0.159 -2 0.803
NTRK1NTRK1 0.658 -0.055 -1 0.558
METMET 0.657 0.019 3 0.746
EPHA3EPHA3 0.657 -0.002 2 0.617
KISKIS 0.657 0.038 1 0.605
EPHA2EPHA2 0.657 0.117 -1 0.552
FGFR1FGFR1 0.656 -0.090 3 0.700
LYNLYN 0.656 0.045 3 0.679
TNK2TNK2 0.655 -0.111 3 0.700
JAK1JAK1 0.655 -0.080 1 0.660
ABL1ABL1 0.655 -0.054 -1 0.552
TTBK1TTBK1 0.654 -0.172 2 0.414
FLT4FLT4 0.654 -0.048 3 0.672
EGFREGFR 0.653 0.054 1 0.755
DDR2DDR2 0.653 -0.001 3 0.670
MATKMATK 0.653 -0.022 -1 0.522
SRCSRC 0.652 0.061 -1 0.606
PTK6PTK6 0.651 -0.121 -1 0.505
MUSKMUSK 0.650 0.016 1 0.728
YANK2YANK2 0.649 -0.082 2 0.312
INSRINSR 0.649 -0.078 3 0.685
TNNI3K_TYRTNNI3K_TYR 0.649 -0.122 1 0.676
NTRK2NTRK2 0.648 -0.125 3 0.698
CSKCSK 0.647 -0.027 2 0.620
NTRK3NTRK3 0.647 -0.078 -1 0.527
ERBB4ERBB4 0.645 0.103 1 0.789
IGF1RIGF1R 0.644 -0.020 3 0.619
FGFR4FGFR4 0.643 -0.024 -1 0.527
ZAP70ZAP70 0.643 0.113 -1 0.585
FESFES 0.638 -0.010 -1 0.510
CK1G1CK1G1 0.617 -0.104 -3 0.451
CK1G3CK1G3 0.610 -0.081 -3 0.297
CK1G2CK1G2 0.606 -0.030 -3 0.377
CK1ACK1A 0.598 -0.057 -3 0.341