Motif 1110 (n=54)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B2RTY4 | MYO9A | T41 | ochoa | Unconventional myosin-IXa (Unconventional myosin-9a) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity). {ECO:0000250|UniProtKB:Q8C170, ECO:0000250|UniProtKB:Q9Z1N3}. |
| C9JRZ8 | AKR1B15 | T244 | ochoa | Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) | [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:21276782, PubMed:26222439). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439). {ECO:0000269|PubMed:21276782, ECO:0000269|PubMed:25577493, ECO:0000269|PubMed:26222439}.; FUNCTION: [Isoform 2]: No oxidoreductase activity observed with the tested substrates. {ECO:0000269|PubMed:25577493}. |
| O15357 | INPPL1 | T301 | ochoa | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569). {ECO:0000250|UniProtKB:F1PNY0, ECO:0000250|UniProtKB:Q6P549, ECO:0000250|UniProtKB:Q9WVR3, ECO:0000269|PubMed:11016922, ECO:0000269|PubMed:11349134, ECO:0000269|PubMed:11739414, ECO:0000269|PubMed:12235291, ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:15668240, ECO:0000269|PubMed:15735664, ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:17135240, ECO:0000269|PubMed:21624956, ECO:0000269|PubMed:23273569, ECO:0000269|PubMed:9660833}. |
| O15446 | POLR1G | T421 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O60716 | CTNND1 | T643 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
| O95997 | PTTG1 | T60 | psp | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}. |
| P02545 | LMNA | T534 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| P12882 | MYH1 | T71 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T70 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P15121 | AKR1B1 | T244 | ochoa | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:1936586, ECO:0000269|PubMed:21329684, ECO:0000269|PubMed:8343525}. |
| P19429 | TNNI3 | T129 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P22314 | UBA1 | T274 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P30622 | CLIP1 | T286 | ochoa | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| P31645 | SLC6A4 | T603 | psp | Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) | Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). {ECO:0000250|UniProtKB:P31652, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:10407194, ECO:0000269|PubMed:12869649, ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18317590, ECO:0000269|PubMed:21730057, ECO:0000269|PubMed:27049939, ECO:0000269|PubMed:27756841, ECO:0000269|PubMed:34851672}. |
| P41236 | PPP1R2 | T21 | ochoa | Protein phosphatase inhibitor 2 (IPP-2) | Inhibitor of protein-phosphatase 1. |
| P50851 | LRBA | T1585 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P60709 | ACTB | T324 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62736 | ACTA2 | T326 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | T324 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | T325 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | T326 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68133 | ACTA1 | T326 | ochoa | Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P78371 | CCT2 | T246 | ochoa | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q00013 | MPP1 | T384 | ochoa | 55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}. |
| Q03164 | KMT2A | T2652 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05D60 | DEUP1 | T527 | ochoa | Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67) | Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). {ECO:0000250}. |
| Q07157 | TJP1 | T412 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q13123 | IK | T329 | ochoa | Protein Red (Cytokine IK) (IK factor) (Protein RER) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}. |
| Q13428 | TCOF1 | S120 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13642 | FHL1 | T79 | ochoa | Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1) | May have an involvement in muscle development or hypertrophy. |
| Q13813 | SPTAN1 | T1000 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14194 | CRMP1 | T101 | psp | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}. |
| Q15208 | STK38 | T282 | ochoa|psp | Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:32537488, ECO:0000269|PubMed:7761441}. |
| Q1W6H9 | FAM110C | T238 | ochoa | Protein FAM110C | May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. |
| Q3V6T2 | CCDC88A | T1534 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q6NXS1 | PPP1R2B | T21 | ochoa | Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) | Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}. |
| Q6ZV73 | FGD6 | T45 | ochoa | FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24) | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q7Z6Z7 | HUWE1 | T3321 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q8N3R9 | PALS1 | T253 | ochoa | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}. |
| Q8NEY1 | NAV1 | T98 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q96CV9 | OPTN | T202 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q9NPC2 | KCNK9 | T341 | psp | Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2) (Two pore K(+) channel KT3.2) | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:11042359, PubMed:11431495, PubMed:26919430, PubMed:38630723). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (PubMed:22948150, PubMed:38630723). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity) (PubMed:23169818, PubMed:38630723). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In granule neurons, hyperpolarizes the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, supports high-frequency action potential firing and increased neuronal excitability. Homomeric and/or heteromeric KCNK3:KCNK9 channels operate in cerebellar granule cells, whereas heteromeric KCNK1:KCNK9 enables currents in hippocampal dentate gyrus granule neurons (By similarity). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex (By similarity). In retinal ganglion cells, mediates outward currents that regulate action potentials in response to acidification of the synaptic cleft. Involved in transmission of image-forming and nonimage-forming visual information in the retina (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity). {ECO:0000250|UniProtKB:Q3LS21, ECO:0000250|UniProtKB:Q9ES08, ECO:0000269|PubMed:11042359, ECO:0000269|PubMed:11431495, ECO:0000269|PubMed:22948150, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:38630723}. |
| Q9UDT6 | CLIP2 | T293 | ochoa | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein) | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). {ECO:0000250}. |
| Q9UEW8 | STK39 | T354 | ochoa | STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) | Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:21321328). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:12740379, PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities (By similarity). Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:12740379, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:34289367}. |
| Q9UKX2 | MYH2 | T71 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9Y2H1 | STK38L | T283 | ochoa | Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) | Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250, ECO:0000269|PubMed:15037617, ECO:0000269|PubMed:15067004}. |
| Q9Y623 | MYH4 | T71 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| A5YKK6 | CNOT1 | Y851 | Sugiyama | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Plays a role in rapid sperm motility via mediating timely mRNA turnover (By similarity). {ECO:0000250|UniProtKB:Q6ZQ08, ECO:0000269|PubMed:10637334, ECO:0000269|PubMed:16778766, ECO:0000269|PubMed:21278420, ECO:0000269|PubMed:21976065, ECO:0000269|PubMed:21984185, ECO:0000269|PubMed:22367759, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:27558897, ECO:0000269|PubMed:32354837}. |
| O43390 | HNRNPR | T134 | Sugiyama | Heterogeneous nuclear ribonucleoprotein R (hnRNP R) | Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. |
| O60506 | SYNCRIP | T131 | Sugiyama | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}. |
| Q03167 | TGFBR3 | T323 | Sugiyama | Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) | Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed:12958365, PubMed:19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed:18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed:19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed:22562249). By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed:19416857, PubMed:19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed:19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity). {ECO:0000250|UniProtKB:P26342, ECO:0000269|PubMed:18184661, ECO:0000269|PubMed:19325136, ECO:0000269|PubMed:19416857, ECO:0000269|PubMed:19726563, ECO:0000269|PubMed:22562249, ECO:0000269|PubMed:34910520}.; FUNCTION: (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL. {ECO:0000269|PubMed:33626330}. |
| P30040 | ERP29 | T45 | Sugiyama | Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31) | Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. |
| Q9BWD1 | ACAT2 | T209 | Sugiyama | Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase) | Involved in the biosynthetic pathway of cholesterol. {ECO:0000303|PubMed:15733928}. |
| P31327 | CPS1 | T206 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9764561 | Regulation of CDH1 Function | 1.103965e-08 | 7.957 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 1.188034e-08 | 7.925 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 1.307186e-06 | 5.884 |
| R-HSA-421270 | Cell-cell junction organization | 1.549500e-05 | 4.810 |
| R-HSA-1500931 | Cell-Cell communication | 9.476982e-06 | 5.023 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.441483e-05 | 4.841 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.441483e-05 | 4.841 |
| R-HSA-446728 | Cell junction organization | 3.037384e-05 | 4.518 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.956275e-05 | 4.529 |
| R-HSA-418990 | Adherens junctions interactions | 5.593614e-05 | 4.252 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.477280e-04 | 3.831 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 2.931014e-04 | 3.533 |
| R-HSA-9839394 | TGFBR3 expression | 2.981516e-04 | 3.526 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.575670e-04 | 3.447 |
| R-HSA-397014 | Muscle contraction | 3.878657e-04 | 3.411 |
| R-HSA-9659379 | Sensory processing of sound | 4.701550e-04 | 3.328 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 5.183206e-04 | 3.285 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.380572e-04 | 3.269 |
| R-HSA-390522 | Striated Muscle Contraction | 6.239127e-04 | 3.205 |
| R-HSA-196025 | Formation of annular gap junctions | 9.722124e-04 | 3.012 |
| R-HSA-190873 | Gap junction degradation | 1.153962e-03 | 2.938 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.350731e-03 | 2.869 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.473704e-03 | 2.832 |
| R-HSA-75153 | Apoptotic execution phase | 1.473704e-03 | 2.832 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.718156e-03 | 2.765 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.839990e-03 | 2.547 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 3.445232e-03 | 2.463 |
| R-HSA-1474244 | Extracellular matrix organization | 3.188141e-03 | 2.496 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.853994e-03 | 2.414 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 4.118037e-03 | 2.385 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 5.220997e-03 | 2.282 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 5.615551e-03 | 2.251 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.444333e-03 | 2.191 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 6.722583e-03 | 2.172 |
| R-HSA-9692912 | SARS-CoV-1 targets PDZ proteins in cell-cell junction | 8.164230e-03 | 2.088 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 9.240118e-03 | 2.034 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.027229e-02 | 1.988 |
| R-HSA-9839397 | TGFBR3 regulates FGF2 signaling | 1.222169e-02 | 1.913 |
| R-HSA-1299316 | TWIK-releated acid-sensitive K+ channel (TASK) | 1.222169e-02 | 1.913 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 1.222169e-02 | 1.913 |
| R-HSA-9839406 | TGFBR3 regulates activin signaling | 1.626281e-02 | 1.789 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.426293e-02 | 1.846 |
| R-HSA-68882 | Mitotic Anaphase | 1.619157e-02 | 1.791 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.641819e-02 | 1.785 |
| R-HSA-373760 | L1CAM interactions | 1.650388e-02 | 1.782 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.617236e-02 | 1.791 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.745901e-02 | 1.758 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.745901e-02 | 1.758 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.092896e-02 | 1.679 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.092896e-02 | 1.679 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.092896e-02 | 1.679 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.092896e-02 | 1.679 |
| R-HSA-437239 | Recycling pathway of L1 | 2.165475e-02 | 1.664 |
| R-HSA-190828 | Gap junction trafficking | 1.950890e-02 | 1.710 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.165475e-02 | 1.664 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.950890e-02 | 1.710 |
| R-HSA-194138 | Signaling by VEGF | 2.002941e-02 | 1.698 |
| R-HSA-191650 | Regulation of gap junction activity | 2.429625e-02 | 1.614 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.622406e-02 | 1.581 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.622406e-02 | 1.581 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.690485e-02 | 1.570 |
| R-HSA-9664407 | Parasite infection | 2.690485e-02 | 1.570 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.690485e-02 | 1.570 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.734391e-02 | 1.563 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 3.226508e-02 | 1.491 |
| R-HSA-9842640 | Signaling by LTK in cancer | 3.622542e-02 | 1.441 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.946788e-02 | 1.531 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 3.226508e-02 | 1.491 |
| R-HSA-9006936 | Signaling by TGFB family members | 3.692756e-02 | 1.433 |
| R-HSA-196071 | Metabolism of steroid hormones | 3.822731e-02 | 1.418 |
| R-HSA-109581 | Apoptosis | 3.796935e-02 | 1.421 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 4.016980e-02 | 1.396 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.197655e-02 | 1.377 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 4.293473e-02 | 1.367 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 4.390109e-02 | 1.358 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 4.409828e-02 | 1.356 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 5.965446e-02 | 1.224 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 5.932506e-02 | 1.227 |
| R-HSA-9762292 | Regulation of CDH11 function | 5.190779e-02 | 1.285 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 5.578895e-02 | 1.253 |
| R-HSA-391251 | Protein folding | 6.594692e-02 | 1.181 |
| R-HSA-5652227 | Fructose biosynthesis | 4.409828e-02 | 1.356 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 4.409828e-02 | 1.356 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 6.350439e-02 | 1.197 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 4.409828e-02 | 1.356 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 5.190779e-02 | 1.285 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 5.965446e-02 | 1.224 |
| R-HSA-1296346 | Tandem pore domain potassium channels | 5.190779e-02 | 1.285 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 4.510478e-02 | 1.346 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 5.965446e-02 | 1.224 |
| R-HSA-193144 | Estrogen biosynthesis | 6.350439e-02 | 1.197 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 4.409828e-02 | 1.356 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 4.801092e-02 | 1.319 |
| R-HSA-9013694 | Signaling by NOTCH4 | 4.487556e-02 | 1.348 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.088811e-02 | 1.293 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.594692e-02 | 1.181 |
| R-HSA-162582 | Signal Transduction | 6.255607e-02 | 1.204 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 5.824533e-02 | 1.235 |
| R-HSA-381070 | IRE1alpha activates chaperones | 6.482656e-02 | 1.188 |
| R-HSA-5357801 | Programmed Cell Death | 6.527095e-02 | 1.185 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 6.733879e-02 | 1.172 |
| R-HSA-190373 | FGFR1c ligand binding and activation | 6.733879e-02 | 1.172 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 9.746247e-02 | 1.011 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.158010e-01 | 0.936 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.230332e-01 | 0.910 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 8.252238e-02 | 1.083 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.266275e-01 | 0.897 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.271882e-01 | 0.896 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 7.115773e-02 | 1.148 |
| R-HSA-5576886 | Phase 4 - resting membrane potential | 7.874946e-02 | 1.104 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 1.266275e-01 | 0.897 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.011599e-01 | 0.995 |
| R-HSA-420029 | Tight junction interactions | 1.194244e-01 | 0.923 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.302072e-01 | 0.885 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.048424e-01 | 0.979 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.194244e-01 | 0.923 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.194244e-01 | 0.923 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 9.002262e-02 | 1.046 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 1.337725e-01 | 0.874 |
| R-HSA-429947 | Deadenylation of mRNA | 1.158010e-01 | 0.936 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 7.115773e-02 | 1.148 |
| R-HSA-1502540 | Signaling by Activin | 7.496126e-02 | 1.125 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 7.496126e-02 | 1.125 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 9.746247e-02 | 1.011 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 1.266275e-01 | 0.897 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 7.115773e-02 | 1.148 |
| R-HSA-70370 | Galactose catabolism | 8.252238e-02 | 1.083 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 1.121629e-01 | 0.950 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.716235e-02 | 1.060 |
| R-HSA-68886 | M Phase | 8.362839e-02 | 1.078 |
| R-HSA-5652084 | Fructose metabolism | 1.085100e-01 | 0.965 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.040201e-02 | 1.095 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 8.252238e-02 | 1.083 |
| R-HSA-196108 | Pregnenolone biosynthesis | 9.746247e-02 | 1.011 |
| R-HSA-70635 | Urea cycle | 1.230332e-01 | 0.910 |
| R-HSA-112311 | Neurotransmitter clearance | 1.373233e-01 | 0.862 |
| R-HSA-199991 | Membrane Trafficking | 1.392921e-01 | 0.856 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.336141e-01 | 0.874 |
| R-HSA-68875 | Mitotic Prophase | 1.048768e-01 | 0.979 |
| R-HSA-373753 | Nephrin family interactions | 9.746247e-02 | 1.011 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.085100e-01 | 0.965 |
| R-HSA-9658195 | Leishmania infection | 1.262797e-01 | 0.899 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.262797e-01 | 0.899 |
| R-HSA-5576891 | Cardiac conduction | 1.221178e-01 | 0.913 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.285278e-02 | 1.032 |
| R-HSA-201451 | Signaling by BMP | 1.266275e-01 | 0.897 |
| R-HSA-8964038 | LDL clearance | 1.085100e-01 | 0.965 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.158010e-01 | 0.936 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.158010e-01 | 0.936 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.266275e-01 | 0.897 |
| R-HSA-2028269 | Signaling by Hippo | 8.628008e-02 | 1.064 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.344348e-01 | 0.871 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.401527e-01 | 0.853 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 1.413961e-01 | 0.850 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.478902e-01 | 0.830 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 1.478902e-01 | 0.830 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.513841e-01 | 0.820 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 1.513841e-01 | 0.820 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.548638e-01 | 0.810 |
| R-HSA-5205647 | Mitophagy | 1.548638e-01 | 0.810 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.548638e-01 | 0.810 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.583295e-01 | 0.800 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 1.663413e-01 | 0.779 |
| R-HSA-8957322 | Metabolism of steroids | 1.673385e-01 | 0.776 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.714065e-01 | 0.766 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 1.720530e-01 | 0.764 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.754492e-01 | 0.756 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 1.773155e-01 | 0.751 |
| R-HSA-1640170 | Cell Cycle | 1.787075e-01 | 0.748 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 1.788318e-01 | 0.748 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.788318e-01 | 0.748 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.788318e-01 | 0.748 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 1.822007e-01 | 0.739 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.855560e-01 | 0.732 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.855560e-01 | 0.732 |
| R-HSA-8854214 | TBC/RABGAPs | 1.888977e-01 | 0.724 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.888977e-01 | 0.724 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.907468e-01 | 0.720 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.955407e-01 | 0.709 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.988420e-01 | 0.701 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.021301e-01 | 0.694 |
| R-HSA-422475 | Axon guidance | 2.021567e-01 | 0.694 |
| R-HSA-9766229 | Degradation of CDH1 | 2.086663e-01 | 0.681 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.173406e-01 | 0.663 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 2.183719e-01 | 0.661 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 2.215809e-01 | 0.654 |
| R-HSA-1221632 | Meiotic synapsis | 2.215809e-01 | 0.654 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 2.279602e-01 | 0.642 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.299988e-01 | 0.638 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 2.311305e-01 | 0.636 |
| R-HSA-75893 | TNF signaling | 2.311305e-01 | 0.636 |
| R-HSA-5578775 | Ion homeostasis | 2.311305e-01 | 0.636 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.311305e-01 | 0.636 |
| R-HSA-72172 | mRNA Splicing | 2.339256e-01 | 0.631 |
| R-HSA-9675108 | Nervous system development | 2.341475e-01 | 0.631 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.342880e-01 | 0.630 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.405647e-01 | 0.619 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 2.436840e-01 | 0.613 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 2.498848e-01 | 0.602 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 2.498848e-01 | 0.602 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 2.498848e-01 | 0.602 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.523559e-01 | 0.598 |
| R-HSA-373755 | Semaphorin interactions | 2.529664e-01 | 0.597 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.618715e-01 | 0.582 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.621366e-01 | 0.581 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.681884e-01 | 0.572 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.703348e-01 | 0.568 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.771745e-01 | 0.557 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.771745e-01 | 0.557 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 2.771745e-01 | 0.557 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.771745e-01 | 0.557 |
| R-HSA-3247509 | Chromatin modifying enzymes | 2.794508e-01 | 0.554 |
| R-HSA-157118 | Signaling by NOTCH | 2.885612e-01 | 0.540 |
| R-HSA-8852135 | Protein ubiquitination | 2.889872e-01 | 0.539 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 2.919105e-01 | 0.535 |
| R-HSA-5689603 | UCH proteinases | 2.919105e-01 | 0.535 |
| R-HSA-73864 | RNA Polymerase I Transcription | 2.977217e-01 | 0.526 |
| R-HSA-191273 | Cholesterol biosynthesis | 2.977217e-01 | 0.526 |
| R-HSA-4839726 | Chromatin organization | 3.022056e-01 | 0.520 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 3.034859e-01 | 0.518 |
| R-HSA-6798695 | Neutrophil degranulation | 3.120763e-01 | 0.506 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.148749e-01 | 0.502 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.148749e-01 | 0.502 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 3.148749e-01 | 0.502 |
| R-HSA-168249 | Innate Immune System | 3.157762e-01 | 0.501 |
| R-HSA-1500620 | Meiosis | 3.176934e-01 | 0.498 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.205005e-01 | 0.494 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.205005e-01 | 0.494 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.233459e-01 | 0.490 |
| R-HSA-9663891 | Selective autophagy | 3.288536e-01 | 0.483 |
| R-HSA-9645723 | Diseases of programmed cell death | 3.288536e-01 | 0.483 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 3.425512e-01 | 0.465 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 3.473189e-01 | 0.459 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.559735e-01 | 0.449 |
| R-HSA-1296071 | Potassium Channels | 3.559735e-01 | 0.449 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 3.586253e-01 | 0.445 |
| R-HSA-190236 | Signaling by FGFR | 3.612665e-01 | 0.442 |
| R-HSA-3214847 | HATs acetylate histones | 3.638969e-01 | 0.439 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.665166e-01 | 0.436 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.717243e-01 | 0.430 |
| R-HSA-1483255 | PI Metabolism | 3.717243e-01 | 0.430 |
| R-HSA-5696398 | Nucleotide Excision Repair | 3.820134e-01 | 0.418 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 3.820134e-01 | 0.418 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 3.845597e-01 | 0.415 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.921366e-01 | 0.407 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.946417e-01 | 0.404 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.946417e-01 | 0.404 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.996216e-01 | 0.398 |
| R-HSA-9007101 | Rab regulation of trafficking | 4.167355e-01 | 0.380 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.262982e-01 | 0.370 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.310214e-01 | 0.366 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.482904e-01 | 0.348 |
| R-HSA-1474165 | Reproduction | 4.518066e-01 | 0.345 |
| R-HSA-9909396 | Circadian clock | 4.563229e-01 | 0.341 |
| R-HSA-8953854 | Metabolism of RNA | 4.681652e-01 | 0.330 |
| R-HSA-1632852 | Macroautophagy | 4.783608e-01 | 0.320 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 4.932614e-01 | 0.307 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.953556e-01 | 0.305 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.995184e-01 | 0.301 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.077427e-01 | 0.294 |
| R-HSA-73887 | Death Receptor Signaling | 5.077427e-01 | 0.294 |
| R-HSA-9612973 | Autophagy | 5.118048e-01 | 0.291 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 5.450261e-01 | 0.264 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.506530e-01 | 0.259 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.506530e-01 | 0.259 |
| R-HSA-1266738 | Developmental Biology | 5.659303e-01 | 0.247 |
| R-HSA-69275 | G2/M Transition | 5.707047e-01 | 0.244 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 5.742545e-01 | 0.241 |
| R-HSA-5617833 | Cilium Assembly | 5.777755e-01 | 0.238 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.795252e-01 | 0.237 |
| R-HSA-68877 | Mitotic Prometaphase | 5.830032e-01 | 0.234 |
| R-HSA-389948 | Co-inhibition by PD-1 | 5.949547e-01 | 0.226 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 5.983069e-01 | 0.223 |
| R-HSA-112316 | Neuronal System | 5.993181e-01 | 0.222 |
| R-HSA-168256 | Immune System | 6.082772e-01 | 0.216 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.178544e-01 | 0.209 |
| R-HSA-1280218 | Adaptive Immune System | 6.441582e-01 | 0.191 |
| R-HSA-5688426 | Deubiquitination | 6.791734e-01 | 0.168 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 6.805084e-01 | 0.167 |
| R-HSA-69620 | Cell Cycle Checkpoints | 6.831621e-01 | 0.165 |
| R-HSA-9679506 | SARS-CoV Infections | 6.884374e-01 | 0.162 |
| R-HSA-5663205 | Infectious disease | 7.158745e-01 | 0.145 |
| R-HSA-1483257 | Phospholipid metabolism | 7.285178e-01 | 0.138 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.554783e-01 | 0.122 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.585308e-01 | 0.120 |
| R-HSA-9709957 | Sensory Perception | 7.676936e-01 | 0.115 |
| R-HSA-73894 | DNA Repair | 7.932293e-01 | 0.101 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.184821e-01 | 0.087 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.237496e-01 | 0.084 |
| R-HSA-74160 | Gene expression (Transcription) | 8.403246e-01 | 0.076 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.413618e-01 | 0.075 |
| R-HSA-1643685 | Disease | 8.496333e-01 | 0.071 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.619800e-01 | 0.065 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.676896e-01 | 0.062 |
| R-HSA-556833 | Metabolism of lipids | 8.769790e-01 | 0.057 |
| R-HSA-212436 | Generic Transcription Pathway | 8.966375e-01 | 0.047 |
| R-HSA-382551 | Transport of small molecules | 9.225083e-01 | 0.035 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.308543e-01 | 0.031 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.309135e-01 | 0.031 |
| R-HSA-2262752 | Cellular responses to stress | 9.319739e-01 | 0.031 |
| R-HSA-449147 | Signaling by Interleukins | 9.329474e-01 | 0.030 |
| R-HSA-9824446 | Viral Infection Pathways | 9.539758e-01 | 0.020 |
| R-HSA-8953897 | Cellular responses to stimuli | 9.568924e-01 | 0.019 |
| R-HSA-109582 | Hemostasis | 9.661125e-01 | 0.015 |
| R-HSA-597592 | Post-translational protein modification | 9.737455e-01 | 0.012 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 9.904180e-01 | 0.004 |
| R-HSA-392499 | Metabolism of proteins | 9.930937e-01 | 0.003 |
| R-HSA-1430728 | Metabolism | 9.998186e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
TNIK |
0.698 | 0.115 | 3 | 0.607 |
MST1 |
0.697 | 0.128 | 1 | 0.740 |
MYO3A |
0.697 | 0.149 | 1 | 0.759 |
GAK |
0.696 | 0.009 | 1 | 0.725 |
MINK |
0.695 | 0.081 | 1 | 0.751 |
TAK1 |
0.695 | 0.080 | 1 | 0.730 |
MST3 |
0.695 | 0.187 | 2 | 0.710 |
NEK1 |
0.695 | 0.071 | 1 | 0.755 |
VRK1 |
0.694 | 0.017 | 2 | 0.614 |
GCK |
0.693 | 0.077 | 1 | 0.750 |
PKR |
0.693 | 0.050 | 1 | 0.766 |
KHS1 |
0.692 | 0.095 | 1 | 0.742 |
HGK |
0.692 | 0.084 | 3 | 0.620 |
MST2 |
0.691 | 0.091 | 1 | 0.740 |
ASK1 |
0.690 | 0.024 | 1 | 0.684 |
MAP3K15 |
0.690 | 0.078 | 1 | 0.709 |
MYO3B |
0.690 | 0.084 | 2 | 0.663 |
EEF2K |
0.689 | 0.079 | 3 | 0.634 |
VRK2 |
0.689 | -0.058 | 1 | 0.764 |
TAO2 |
0.689 | 0.081 | 2 | 0.689 |
KHS2 |
0.688 | 0.077 | 1 | 0.746 |
NEK5 |
0.687 | 0.040 | 1 | 0.778 |
MPSK1 |
0.687 | 0.105 | 1 | 0.701 |
NEK4 |
0.687 | 0.064 | 1 | 0.753 |
HPK1 |
0.686 | 0.068 | 1 | 0.742 |
YSK1 |
0.686 | 0.086 | 2 | 0.650 |
TTK |
0.685 | 0.032 | -2 | 0.601 |
LRRK2 |
0.685 | -0.052 | 2 | 0.621 |
NEK11 |
0.685 | 0.094 | 1 | 0.754 |
MEKK2 |
0.685 | 0.030 | 2 | 0.609 |
ANKRD3 |
0.683 | 0.099 | 1 | 0.795 |
PDK1 |
0.683 | -0.016 | 1 | 0.783 |
TAO3 |
0.683 | 0.050 | 1 | 0.714 |
MLK3 |
0.682 | 0.269 | 2 | 0.685 |
MEKK6 |
0.681 | 0.037 | 1 | 0.723 |
MLK2 |
0.679 | 0.135 | 2 | 0.640 |
CAMKK2 |
0.679 | -0.066 | -2 | 0.490 |
MEK5 |
0.679 | -0.048 | 2 | 0.611 |
BMPR2 |
0.678 | -0.077 | -2 | 0.619 |
OSR1 |
0.678 | -0.015 | 2 | 0.601 |
MEK1 |
0.678 | -0.103 | 2 | 0.621 |
MEKK1 |
0.678 | 0.009 | 1 | 0.755 |
MOS |
0.677 | 0.134 | 1 | 0.691 |
NIK |
0.677 | -0.010 | -3 | 0.647 |
BIKE |
0.677 | -0.002 | 1 | 0.626 |
CAMKK1 |
0.676 | -0.094 | -2 | 0.491 |
NEK8 |
0.676 | 0.001 | 2 | 0.624 |
BRAF |
0.676 | -0.090 | -4 | 0.624 |
HASPIN |
0.675 | 0.076 | -1 | 0.500 |
P38A |
0.675 | 0.081 | 1 | 0.560 |
MLK1 |
0.675 | 0.192 | 2 | 0.672 |
YSK4 |
0.674 | 0.050 | 1 | 0.702 |
LOK |
0.673 | 0.024 | -2 | 0.524 |
PRPK |
0.673 | -0.025 | -1 | 0.596 |
LKB1 |
0.673 | -0.119 | -3 | 0.673 |
ZAK |
0.673 | 0.029 | 1 | 0.718 |
TAO1 |
0.672 | 0.050 | 1 | 0.696 |
ALK4 |
0.672 | -0.040 | -2 | 0.578 |
CDKL1 |
0.671 | 0.063 | -3 | 0.552 |
MEK2 |
0.671 | -0.118 | 2 | 0.574 |
MEKK3 |
0.670 | -0.017 | 1 | 0.741 |
NLK |
0.670 | 0.056 | 1 | 0.695 |
DAPK2 |
0.670 | -0.071 | -3 | 0.639 |
STLK3 |
0.669 | -0.106 | 1 | 0.682 |
CAMLCK |
0.668 | -0.066 | -2 | 0.543 |
TGFBR1 |
0.668 | -0.007 | -2 | 0.571 |
AAK1 |
0.668 | 0.015 | 1 | 0.537 |
DLK |
0.667 | -0.072 | 1 | 0.734 |
P38B |
0.667 | 0.058 | 1 | 0.480 |
ICK |
0.667 | 0.057 | -3 | 0.602 |
MLK4 |
0.666 | 0.121 | 2 | 0.588 |
COT |
0.666 | 0.132 | 2 | 0.679 |
PBK |
0.666 | -0.042 | 1 | 0.675 |
ALK2 |
0.666 | -0.039 | -2 | 0.576 |
ALPHAK3 |
0.666 | -0.058 | -1 | 0.566 |
PKCD |
0.665 | 0.128 | 2 | 0.685 |
PLK1 |
0.665 | 0.006 | -2 | 0.592 |
BMPR1B |
0.665 | 0.026 | 1 | 0.635 |
DMPK1 |
0.665 | -0.034 | -3 | 0.523 |
HRI |
0.665 | -0.015 | -2 | 0.567 |
IRAK4 |
0.665 | 0.045 | 1 | 0.764 |
PASK |
0.665 | -0.056 | -3 | 0.608 |
MST4 |
0.665 | 0.169 | 2 | 0.752 |
NEK9 |
0.664 | 0.023 | 2 | 0.634 |
CAMK1B |
0.664 | -0.069 | -3 | 0.621 |
CAMK2G |
0.664 | 0.010 | 2 | 0.641 |
NEK2 |
0.664 | 0.031 | 2 | 0.608 |
PRP4 |
0.663 | -0.002 | -3 | 0.614 |
ATR |
0.663 | -0.038 | 1 | 0.691 |
RIPK3 |
0.663 | 0.110 | 3 | 0.583 |
SMMLCK |
0.662 | -0.048 | -3 | 0.581 |
MAK |
0.662 | 0.113 | -2 | 0.689 |
WNK1 |
0.662 | 0.041 | -2 | 0.602 |
SLK |
0.662 | -0.020 | -2 | 0.528 |
TLK1 |
0.661 | -0.066 | -2 | 0.603 |
CHAK2 |
0.660 | 0.018 | -1 | 0.581 |
LATS1 |
0.659 | -0.070 | -3 | 0.630 |
SKMLCK |
0.659 | -0.029 | -2 | 0.575 |
TLK2 |
0.659 | -0.092 | 1 | 0.736 |
NEK3 |
0.659 | -0.030 | 1 | 0.742 |
JNK2 |
0.659 | -0.008 | 1 | 0.473 |
PKN2 |
0.659 | 0.087 | -3 | 0.606 |
PERK |
0.659 | -0.089 | -2 | 0.575 |
ROCK2 |
0.658 | -0.047 | -3 | 0.562 |
RAF1 |
0.658 | -0.060 | 1 | 0.741 |
WNK4 |
0.657 | -0.051 | -2 | 0.600 |
BUB1 |
0.657 | 0.039 | -5 | 0.526 |
PLK3 |
0.657 | -0.016 | 2 | 0.578 |
CDKL5 |
0.657 | 0.099 | -3 | 0.557 |
PKN3 |
0.657 | 0.032 | -3 | 0.587 |
DSTYK |
0.657 | 0.055 | 2 | 0.700 |
ACVR2B |
0.657 | -0.024 | -2 | 0.549 |
PKCA |
0.656 | 0.136 | 2 | 0.653 |
ERK5 |
0.656 | 0.020 | 1 | 0.644 |
JNK3 |
0.656 | -0.027 | 1 | 0.509 |
CDK5 |
0.655 | 0.063 | 1 | 0.538 |
ACVR2A |
0.655 | -0.040 | -2 | 0.533 |
MASTL |
0.655 | -0.114 | -2 | 0.598 |
GRK7 |
0.654 | -0.002 | 1 | 0.621 |
NEK7 |
0.653 | 0.016 | -3 | 0.664 |
NUAK2 |
0.652 | 0.006 | -3 | 0.605 |
HUNK |
0.652 | -0.031 | 2 | 0.575 |
RIPK1 |
0.652 | -0.085 | 1 | 0.783 |
PKCB |
0.652 | 0.146 | 2 | 0.667 |
PDHK4 |
0.652 | -0.155 | 1 | 0.750 |
TSSK2 |
0.651 | -0.062 | -5 | 0.632 |
PKCG |
0.651 | 0.154 | 2 | 0.682 |
PKCH |
0.651 | 0.105 | 2 | 0.614 |
IRE1 |
0.651 | 0.053 | 1 | 0.745 |
NEK6 |
0.651 | 0.047 | -2 | 0.613 |
DAPK3 |
0.651 | -0.088 | -3 | 0.555 |
MOK |
0.650 | 0.053 | 1 | 0.621 |
AMPKA1 |
0.650 | -0.051 | -3 | 0.630 |
ERK1 |
0.650 | 0.051 | 1 | 0.483 |
CDK1 |
0.649 | 0.033 | 1 | 0.484 |
CHAK1 |
0.649 | -0.016 | 2 | 0.569 |
BMPR1A |
0.649 | -0.025 | 1 | 0.612 |
DRAK1 |
0.649 | -0.004 | 1 | 0.716 |
ERK2 |
0.648 | 0.005 | 1 | 0.536 |
DNAPK |
0.648 | -0.041 | 1 | 0.625 |
CDK16 |
0.648 | 0.097 | 1 | 0.423 |
ULK2 |
0.648 | -0.006 | 2 | 0.564 |
IRE2 |
0.648 | 0.057 | 2 | 0.562 |
PDHK1 |
0.648 | -0.141 | 1 | 0.736 |
MARK4 |
0.648 | -0.031 | 4 | 0.739 |
TGFBR2 |
0.648 | -0.007 | -2 | 0.555 |
GRK5 |
0.647 | -0.117 | -3 | 0.596 |
PKCE |
0.647 | 0.112 | 2 | 0.668 |
PKCZ |
0.647 | 0.043 | 2 | 0.608 |
DCAMKL2 |
0.647 | -0.044 | -3 | 0.597 |
ERK7 |
0.646 | -0.014 | 2 | 0.386 |
PLK2 |
0.646 | -0.005 | -3 | 0.565 |
IRAK1 |
0.646 | -0.077 | -1 | 0.504 |
GRK1 |
0.645 | 0.077 | -2 | 0.632 |
GRK6 |
0.645 | -0.083 | 1 | 0.701 |
P38G |
0.645 | -0.002 | 1 | 0.408 |
TSSK1 |
0.645 | -0.064 | -3 | 0.659 |
TBK1 |
0.644 | -0.018 | 1 | 0.714 |
MTOR |
0.644 | -0.022 | 1 | 0.687 |
DCAMKL1 |
0.644 | -0.086 | -3 | 0.569 |
ROCK1 |
0.644 | -0.058 | -3 | 0.521 |
CLK3 |
0.644 | 0.025 | 1 | 0.659 |
TTBK2 |
0.644 | -0.028 | 2 | 0.559 |
PIM3 |
0.644 | -0.036 | -3 | 0.585 |
STK33 |
0.643 | -0.036 | 2 | 0.497 |
HIPK1 |
0.643 | -0.006 | 1 | 0.597 |
P38D |
0.642 | 0.001 | 1 | 0.427 |
WNK3 |
0.642 | -0.091 | 1 | 0.755 |
PLK4 |
0.642 | -0.010 | 2 | 0.401 |
GRK2 |
0.642 | -0.043 | -2 | 0.551 |
IKKE |
0.641 | -0.007 | 1 | 0.712 |
CDK14 |
0.641 | 0.026 | 1 | 0.514 |
PINK1 |
0.640 | -0.150 | 1 | 0.716 |
SGK3 |
0.640 | -0.036 | -3 | 0.553 |
CDK2 |
0.640 | 0.004 | 1 | 0.562 |
SMG1 |
0.640 | -0.062 | 1 | 0.653 |
PIM1 |
0.640 | -0.052 | -3 | 0.521 |
MRCKB |
0.639 | -0.054 | -3 | 0.509 |
CAMK2D |
0.639 | -0.072 | -3 | 0.635 |
CDK3 |
0.639 | 0.043 | 1 | 0.424 |
CHK1 |
0.639 | -0.130 | -3 | 0.632 |
PKCI |
0.639 | 0.038 | 2 | 0.608 |
HIPK4 |
0.638 | 0.023 | 1 | 0.670 |
CDK6 |
0.638 | -0.000 | 1 | 0.498 |
PKCT |
0.638 | 0.070 | 2 | 0.619 |
CDC7 |
0.638 | -0.065 | 1 | 0.664 |
GSK3A |
0.637 | -0.009 | 4 | 0.260 |
DAPK1 |
0.637 | -0.096 | -3 | 0.530 |
HIPK3 |
0.637 | -0.015 | 1 | 0.607 |
SSTK |
0.637 | -0.013 | 4 | 0.742 |
CDK18 |
0.637 | 0.055 | 1 | 0.463 |
PIM2 |
0.636 | -0.064 | -3 | 0.517 |
JNK1 |
0.636 | -0.042 | 1 | 0.456 |
GSK3B |
0.636 | -0.028 | 4 | 0.257 |
ATM |
0.635 | -0.059 | 1 | 0.632 |
CDK17 |
0.635 | 0.031 | 1 | 0.412 |
AMPKA2 |
0.635 | -0.067 | -3 | 0.598 |
RIPK2 |
0.634 | -0.077 | 1 | 0.698 |
QIK |
0.634 | -0.057 | -3 | 0.622 |
MARK2 |
0.633 | -0.053 | 4 | 0.697 |
MRCKA |
0.633 | -0.092 | -3 | 0.521 |
MYLK4 |
0.632 | -0.063 | -2 | 0.455 |
CDK8 |
0.632 | 0.022 | 1 | 0.536 |
PAK1 |
0.632 | -0.057 | -2 | 0.490 |
P70S6KB |
0.631 | -0.092 | -3 | 0.557 |
DYRK1A |
0.630 | -0.019 | 1 | 0.599 |
TTBK1 |
0.630 | -0.016 | 2 | 0.514 |
MARK3 |
0.630 | -0.036 | 4 | 0.719 |
CAMK1G |
0.630 | -0.046 | -3 | 0.514 |
DYRK2 |
0.630 | -0.040 | 1 | 0.580 |
MELK |
0.629 | -0.086 | -3 | 0.596 |
IKKB |
0.629 | -0.067 | -2 | 0.521 |
CDK4 |
0.629 | -0.021 | 1 | 0.467 |
AKT2 |
0.629 | -0.046 | -3 | 0.460 |
MARK1 |
0.628 | -0.071 | 4 | 0.724 |
NIM1 |
0.628 | -0.072 | 3 | 0.581 |
CAMK2B |
0.627 | -0.073 | 2 | 0.620 |
GRK4 |
0.627 | -0.116 | -2 | 0.627 |
ULK1 |
0.627 | -0.070 | -3 | 0.627 |
CDK7 |
0.627 | 0.004 | 1 | 0.520 |
IKKA |
0.627 | -0.051 | -2 | 0.549 |
SRPK1 |
0.627 | -0.023 | -3 | 0.511 |
PAK2 |
0.627 | -0.111 | -2 | 0.474 |
PAK3 |
0.627 | -0.076 | -2 | 0.469 |
QSK |
0.627 | -0.056 | 4 | 0.747 |
PKG2 |
0.626 | -0.028 | -2 | 0.400 |
PHKG1 |
0.626 | 0.040 | -3 | 0.594 |
CRIK |
0.626 | -0.104 | -3 | 0.489 |
NUAK1 |
0.626 | -0.016 | -3 | 0.560 |
CAMK2A |
0.626 | -0.061 | 2 | 0.650 |
NDR1 |
0.625 | -0.079 | -3 | 0.598 |
MAPKAPK3 |
0.624 | -0.068 | -3 | 0.579 |
GCN2 |
0.624 | -0.089 | 2 | 0.570 |
AURB |
0.624 | -0.060 | -2 | 0.380 |
AKT1 |
0.624 | -0.044 | -3 | 0.490 |
CDK10 |
0.624 | 0.031 | 1 | 0.504 |
MNK2 |
0.623 | -0.030 | -2 | 0.492 |
RSK2 |
0.623 | -0.063 | -3 | 0.546 |
PDHK3_TYR |
0.622 | 0.094 | 4 | 0.705 |
EPHA6 |
0.622 | 0.198 | -1 | 0.650 |
HIPK2 |
0.621 | 0.004 | 1 | 0.497 |
BCKDK |
0.621 | -0.092 | -1 | 0.488 |
SRPK3 |
0.621 | -0.063 | -3 | 0.457 |
CAMK4 |
0.621 | -0.124 | -3 | 0.582 |
CDK13 |
0.620 | -0.036 | 1 | 0.501 |
BMPR2_TYR |
0.619 | 0.136 | -1 | 0.677 |
CDK19 |
0.619 | 0.029 | 1 | 0.503 |
PKN1 |
0.619 | 0.007 | -3 | 0.516 |
MNK1 |
0.619 | -0.040 | -2 | 0.497 |
CDK12 |
0.619 | -0.032 | 1 | 0.483 |
SGK1 |
0.619 | -0.075 | -3 | 0.388 |
PKACG |
0.619 | -0.077 | -2 | 0.479 |
PRKD3 |
0.618 | -0.067 | -3 | 0.541 |
GRK3 |
0.618 | -0.047 | -2 | 0.534 |
CAMK1D |
0.618 | -0.114 | -3 | 0.479 |
CHK2 |
0.618 | -0.090 | -3 | 0.425 |
CLK4 |
0.618 | -0.078 | -3 | 0.517 |
DYRK1B |
0.617 | -0.060 | 1 | 0.552 |
P90RSK |
0.617 | -0.089 | -3 | 0.545 |
YANK3 |
0.617 | -0.022 | 2 | 0.382 |
PRKD1 |
0.617 | -0.068 | -3 | 0.640 |
YANK2 |
0.617 | -0.026 | 2 | 0.401 |
NDR2 |
0.616 | -0.062 | -3 | 0.604 |
PKMYT1_TYR |
0.615 | 0.070 | 3 | 0.656 |
CK2A2 |
0.615 | 0.014 | 1 | 0.542 |
RSK3 |
0.615 | -0.069 | -3 | 0.545 |
AURC |
0.615 | -0.037 | -2 | 0.382 |
CLK1 |
0.614 | -0.049 | -3 | 0.522 |
CK1D |
0.614 | -0.037 | -3 | 0.229 |
DYRK3 |
0.614 | -0.071 | 1 | 0.617 |
LATS2 |
0.614 | -0.091 | -5 | 0.561 |
FAM20C |
0.613 | -0.009 | 2 | 0.465 |
PHKG2 |
0.612 | 0.035 | -3 | 0.577 |
AURA |
0.612 | -0.080 | -2 | 0.366 |
LIMK2_TYR |
0.612 | 0.046 | -3 | 0.702 |
TESK1_TYR |
0.612 | 0.004 | 3 | 0.664 |
DYRK4 |
0.612 | -0.047 | 1 | 0.495 |
PRKD2 |
0.612 | -0.057 | -3 | 0.573 |
MAP2K7_TYR |
0.612 | -0.046 | 2 | 0.634 |
CDK9 |
0.611 | -0.061 | 1 | 0.514 |
CAMK1A |
0.611 | -0.083 | -3 | 0.437 |
PDHK1_TYR |
0.611 | 0.023 | -1 | 0.643 |
SIK |
0.611 | -0.079 | -3 | 0.524 |
RSK4 |
0.610 | -0.074 | -3 | 0.500 |
CK1A2 |
0.609 | -0.030 | -3 | 0.221 |
CK1E |
0.609 | -0.005 | -3 | 0.273 |
LCK |
0.609 | 0.161 | -1 | 0.641 |
PDHK4_TYR |
0.608 | -0.033 | 2 | 0.649 |
CK2A1 |
0.608 | 0.010 | 1 | 0.529 |
MAP2K6_TYR |
0.608 | -0.050 | -1 | 0.614 |
BRSK2 |
0.608 | -0.091 | -3 | 0.607 |
JAK2 |
0.608 | 0.092 | 1 | 0.716 |
MST1R |
0.608 | 0.071 | 3 | 0.622 |
AKT3 |
0.607 | -0.040 | -3 | 0.411 |
PAK6 |
0.607 | -0.031 | -2 | 0.374 |
TYK2 |
0.607 | 0.059 | 1 | 0.724 |
SNRK |
0.607 | -0.123 | 2 | 0.422 |
MSK1 |
0.607 | -0.103 | -3 | 0.516 |
HCK |
0.607 | 0.121 | -1 | 0.619 |
JAK1 |
0.606 | 0.142 | 1 | 0.710 |
MAP2K4_TYR |
0.606 | -0.128 | -1 | 0.603 |
BRSK1 |
0.606 | -0.088 | -3 | 0.569 |
PKACB |
0.606 | -0.069 | -2 | 0.397 |
PINK1_TYR |
0.605 | -0.016 | 1 | 0.716 |
EPHB4 |
0.605 | 0.049 | -1 | 0.590 |
BLK |
0.605 | 0.124 | -1 | 0.639 |
MSK2 |
0.604 | -0.112 | -3 | 0.502 |
SRPK2 |
0.604 | -0.036 | -3 | 0.426 |
LIMK1_TYR |
0.603 | -0.035 | 2 | 0.636 |
TNK2 |
0.603 | 0.056 | 3 | 0.629 |
EPHA4 |
0.603 | 0.041 | 2 | 0.593 |
JAK3 |
0.603 | 0.065 | 1 | 0.709 |
ROS1 |
0.603 | 0.049 | 3 | 0.570 |
MAPKAPK2 |
0.602 | -0.077 | -3 | 0.511 |
RET |
0.602 | -0.034 | 1 | 0.719 |
CSF1R |
0.602 | 0.041 | 3 | 0.607 |
DDR1 |
0.602 | -0.045 | 4 | 0.665 |
TXK |
0.602 | 0.057 | 1 | 0.673 |
PTK2 |
0.601 | 0.157 | -1 | 0.693 |
KDR |
0.601 | 0.061 | 3 | 0.582 |
TNNI3K_TYR |
0.600 | 0.047 | 1 | 0.739 |
TYRO3 |
0.600 | -0.023 | 3 | 0.598 |
WEE1_TYR |
0.599 | 0.039 | -1 | 0.516 |
ITK |
0.599 | 0.034 | -1 | 0.570 |
FYN |
0.599 | 0.109 | -1 | 0.657 |
YES1 |
0.598 | -0.015 | -1 | 0.583 |
P70S6K |
0.598 | -0.122 | -3 | 0.483 |
EPHA7 |
0.598 | 0.080 | 2 | 0.575 |
ABL2 |
0.598 | -0.010 | -1 | 0.551 |
FGR |
0.597 | -0.023 | 1 | 0.718 |
EPHB1 |
0.597 | 0.033 | 1 | 0.695 |
PKACA |
0.597 | -0.080 | -2 | 0.343 |
INSRR |
0.597 | 0.006 | 3 | 0.588 |
KIT |
0.597 | 0.012 | 3 | 0.631 |
MET |
0.596 | 0.050 | 3 | 0.609 |
LYN |
0.595 | 0.075 | 3 | 0.571 |
EPHB2 |
0.595 | 0.020 | -1 | 0.585 |
FLT1 |
0.594 | 0.046 | -1 | 0.621 |
SRMS |
0.594 | -0.017 | 1 | 0.683 |
SBK |
0.594 | -0.116 | -3 | 0.368 |
PDGFRB |
0.594 | -0.018 | 3 | 0.625 |
MAPKAPK5 |
0.593 | -0.135 | -3 | 0.498 |
CLK2 |
0.593 | -0.075 | -3 | 0.503 |
TNK1 |
0.593 | -0.020 | 3 | 0.566 |
EPHB3 |
0.593 | 0.010 | -1 | 0.571 |
BMX |
0.592 | 0.015 | -1 | 0.543 |
ABL1 |
0.592 | -0.043 | -1 | 0.541 |
NEK10_TYR |
0.592 | -0.054 | 1 | 0.622 |
EPHA3 |
0.592 | 0.018 | 2 | 0.563 |
BTK |
0.592 | -0.031 | -1 | 0.512 |
FER |
0.591 | -0.074 | 1 | 0.688 |
FGFR2 |
0.591 | -0.061 | 3 | 0.637 |
FRK |
0.591 | 0.055 | -1 | 0.616 |
TEC |
0.591 | -0.018 | -1 | 0.502 |
DDR2 |
0.590 | 0.031 | 3 | 0.643 |
ALK |
0.590 | 0.019 | 3 | 0.601 |
ERBB2 |
0.590 | -0.015 | 1 | 0.661 |
FLT3 |
0.590 | -0.037 | 3 | 0.585 |
PDGFRA |
0.589 | -0.026 | 3 | 0.614 |
PAK5 |
0.588 | -0.087 | -2 | 0.360 |
EPHA8 |
0.588 | 0.068 | -1 | 0.607 |
EPHA1 |
0.588 | 0.038 | 3 | 0.587 |
FGFR1 |
0.588 | -0.052 | 3 | 0.618 |
MERTK |
0.587 | -0.046 | 3 | 0.573 |
INSR |
0.587 | -0.014 | 3 | 0.564 |
LTK |
0.587 | -0.020 | 3 | 0.616 |
SRC |
0.586 | 0.024 | -1 | 0.607 |
TEK |
0.586 | -0.070 | 3 | 0.574 |
KIS |
0.586 | -0.025 | 1 | 0.534 |
AXL |
0.585 | -0.062 | 3 | 0.605 |
PAK4 |
0.585 | -0.066 | -2 | 0.373 |
FGFR3 |
0.584 | -0.045 | 3 | 0.623 |
PRKX |
0.584 | -0.069 | -3 | 0.455 |
PTK2B |
0.584 | -0.008 | -1 | 0.524 |
EGFR |
0.583 | -0.011 | 1 | 0.571 |
FLT4 |
0.582 | -0.045 | 3 | 0.585 |
EPHA2 |
0.582 | 0.071 | -1 | 0.594 |
EPHA5 |
0.582 | 0.001 | 2 | 0.557 |
SYK |
0.582 | 0.075 | -1 | 0.655 |
PKG1 |
0.582 | -0.079 | -2 | 0.320 |
NTRK2 |
0.581 | -0.055 | 3 | 0.580 |
MATK |
0.580 | -0.054 | -1 | 0.506 |
NTRK3 |
0.580 | -0.040 | -1 | 0.506 |
CSK |
0.580 | -0.035 | 2 | 0.586 |
PTK6 |
0.579 | -0.127 | -1 | 0.475 |
NTRK1 |
0.578 | -0.106 | -1 | 0.539 |
FGFR4 |
0.578 | -0.039 | -1 | 0.538 |
ERBB4 |
0.574 | 0.027 | 1 | 0.572 |
MUSK |
0.574 | -0.011 | 1 | 0.583 |
CK1G1 |
0.571 | -0.079 | -3 | 0.253 |
IGF1R |
0.571 | -0.040 | 3 | 0.526 |
FES |
0.567 | -0.020 | -1 | 0.508 |
CK1G3 |
0.564 | -0.093 | -3 | 0.102 |
ZAP70 |
0.562 | 0.006 | -1 | 0.593 |
CK1G2 |
0.561 | -0.037 | -3 | 0.180 |
CK1A |
0.546 | -0.062 | -3 | 0.146 |