Motif 1109 (n=60)

Position-wise Probabilities

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uniprot genes site source protein function
A6NKT7 RGPD3 T1017 ochoa RanBP2-like and GRIP domain-containing protein 3 None
K7N7A8 None T426 ochoa Ubiquitin carboxyl-terminal hydrolase MINDY (EC 3.4.19.12) Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo. {ECO:0000256|ARBA:ARBA00049627}.; FUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000256|RuleBase:RU367088}.; FUNCTION: Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000256|ARBA:ARBA00037630}.
O14544 SOCS6 T93 ochoa Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}.
O14715 RGPD8 T1016 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O75128 COBL T434 ochoa Protein cordon-bleu Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}.
O75179 ANKRD17 T1565 ochoa Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}.
O75563 SKAP2 T290 ochoa Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}.
O94788 ALDH1A2 T284 ochoa Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:29240402, PubMed:33565183). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable) (PubMed:33565183). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity). {ECO:0000250|UniProtKB:Q63639, ECO:0000269|PubMed:29240402, ECO:0000269|PubMed:33565183, ECO:0000305|PubMed:22075477}.
O94876 TMCC1 T451 ochoa Transmembrane and coiled-coil domains protein 1 Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}.
O94953 KDM4B T305 psp Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.
O96017 CHEK2 T205 psp Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}.
P00352 ALDH1A1 T267 ochoa|psp Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}.
P05091 ALDH2 T283 ochoa Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. {ECO:0000269|PubMed:33355142}.
P08133 ANXA6 T309 ochoa Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
P0DJD0 RGPD1 T1001 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 T1009 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P12532 CKMT1A T142 ochoa Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
P17252 PRKCA T228 ochoa|psp Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}.
P17540 CKMT2 T143 ochoa Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
P20290 BTF3 T82 ochoa Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}.
P21333 FLNA T915 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P28066 PSMA5 T55 ochoa Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
P29972 AQP1 T246 ochoa Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel) Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:16682607, ECO:0000269|PubMed:17012249, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:33028705, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:36949749, ECO:0000269|PubMed:8584435, ECO:0000269|PubMed:8703053}.
P30837 ALDH1B1 T283 ochoa Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
P47895 ALDH1A3 T278 ochoa Retinaldehyde dehydrogenase 3 (RALDH-3) (RalDH3) (EC 1.2.1.36) (Aldehyde dehydrogenase 6) (Aldehyde dehydrogenase family 1 member A3) (ALDH1A3) Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity). {ECO:0000250|UniProtKB:Q9JHW9, ECO:0000269|PubMed:27759097}.
P49792 RANBP2 T1992 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49792 RANBP2 T2610 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P51114 FXR1 T483 ochoa RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}.
Q12802 AKAP13 T655 ochoa A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Q17R91 DIAPH2 T882 psp Protein diaphanous homolog 2 (Diaphanous-related formin-2) None
Q4G163 FBXO43 T234 psp F-box only protein 43 (Endogenous meiotic inhibitor 2) Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q8CDI2, ECO:0000269|PubMed:34052850, ECO:0000269|PubMed:34595750}.
Q4LE39 ARID4B T481 ochoa AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}.
Q4V9L6 TMEM119 T180 ochoa Transmembrane protein 119 (Osteoblast induction factor) (OBIF) Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}.
Q5SW79 CEP170 T484 ochoa Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.
Q5VV67 PPRC1 T169 ochoa Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}.
Q641Q2 WASHC2A T531 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q641Q2 WASHC2A T533 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q6KC79 NIPBL T914 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q7Z333 SETX T952 ochoa Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}.
Q7Z3J3 RGPD4 T1017 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q86XL3 ANKLE2 T629 ochoa Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}.
Q8N5P1 ZC3H8 T20 ochoa Zinc finger CCCH domain-containing protein 8 Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}.
Q8NC24 RELL2 T48 ochoa RELT-like protein 2 Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}.
Q8TAQ2 SMARCC2 T278 ochoa SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
Q92621 NUP205 T1944 ochoa Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}.
Q92766 RREB1 T1199 ochoa Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}.
Q92804 TAF15 T222 ochoa TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}.
Q92995 USP13 T122 ochoa Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response (PubMed:21571647, PubMed:32772043, PubMed:33592542). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy (PubMed:32101753). Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB (PubMed:32772043). In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1 (PubMed:33592542). Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion (PubMed:36585612). Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1 (PubMed:23940278, PubMed:28534493). {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28534493, ECO:0000269|PubMed:32101753, ECO:0000269|PubMed:32772043, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:36585612}.
Q99666 RGPD5 T1016 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q9BVI0 PHF20 T336 ochoa PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}.
Q9BZQ8 NIBAN1 T717 ochoa Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}.
Q9H2M9 RAB3GAP2 T1242 ochoa Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}.
Q9P270 SLAIN2 T313 ochoa SLAIN motif-containing protein 2 Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.
Q9UJX6 ANAPC2 T466 ochoa Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11739784, PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZQ7, ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
Q9Y4F1 FARP1 T883 ochoa FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.
Q9Y6J8 STYXL1 T83 ochoa Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Inactive dual specificity protein phosphatase MK-STYX) (Map kinase phosphatase-like protein MK-STYX) Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526). {ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:21262771, ECO:0000269|PubMed:23163895, ECO:0000269|PubMed:24709986, ECO:0000269|PubMed:29250526}.
Q15648 MED1 T704 EPSD|PSP Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
O76021 RSL1D1 T312 Sugiyama Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}.
P22314 UBA1 Y845 Sugiyama Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}.
P30419 NMT1 T134 Sugiyama Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-) Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017). {ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:32111831, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}.
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reactome_id name p -log10_p
R-HSA-9938206 Developmental Lineage of Mammary Stem Cells 0.000222 3.654
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 0.000424 3.373
R-HSA-71384 Ethanol oxidation 0.000222 3.654
R-HSA-162599 Late Phase of HIV Life Cycle 0.000523 3.281
R-HSA-162906 HIV Infection 0.000539 3.269
R-HSA-5365859 RA biosynthesis pathway 0.000670 3.174
R-HSA-162587 HIV Life Cycle 0.000781 3.107
R-HSA-69541 Stabilization of p53 0.000932 3.030
R-HSA-9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 0.001184 2.927
R-HSA-8851680 Butyrophilin (BTN) family interactions 0.001154 2.938
R-HSA-68886 M Phase 0.001316 2.881
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.001718 2.765
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.001718 2.765
R-HSA-68882 Mitotic Anaphase 0.002880 2.541
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.002932 2.533
R-HSA-2980766 Nuclear Envelope Breakdown 0.002489 2.604
R-HSA-1433559 Regulation of KIT signaling 0.002556 2.593
R-HSA-1640170 Cell Cycle 0.002853 2.545
R-HSA-5362517 Signaling by Retinoic Acid 0.002825 2.549
R-HSA-69615 G1/S DNA Damage Checkpoints 0.003188 2.496
R-HSA-3247509 Chromatin modifying enzymes 0.003931 2.405
R-HSA-9924644 Developmental Lineages of the Mammary Gland 0.004443 2.352
R-HSA-4839726 Chromatin organization 0.004998 2.301
R-HSA-71288 Creatine metabolism 0.004840 2.315
R-HSA-9006931 Signaling by Nuclear Receptors 0.004863 2.313
R-HSA-69620 Cell Cycle Checkpoints 0.005729 2.242
R-HSA-9734767 Developmental Cell Lineages 0.006167 2.210
R-HSA-5633007 Regulation of TP53 Activity 0.006244 2.205
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.007124 2.147
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.009750 2.011
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.010272 1.988
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.010272 1.988
R-HSA-1855170 IPs transport between nucleus and cytosol 0.011353 1.945
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.011353 1.945
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.011912 1.924
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.013064 1.884
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.015508 1.809
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.016147 1.792
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.016147 1.792
R-HSA-167161 HIV Transcription Initiation 0.017459 1.758
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.017459 1.758
R-HSA-73776 RNA Polymerase II Promoter Escape 0.018815 1.726
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.017459 1.758
R-HSA-9927426 Developmental Lineage of Mammary Gland Alveolar Cells 0.012482 1.904
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.014263 1.846
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 0.013360 1.874
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.011912 1.924
R-HSA-180746 Nuclear import of Rev protein 0.012482 1.904
R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria 0.016263 1.789
R-HSA-177243 Interactions of Rev with host cellular proteins 0.016147 1.792
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.016147 1.792
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.016797 1.775
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.014880 1.827
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.015508 1.809
R-HSA-69278 Cell Cycle, Mitotic 0.010167 1.993
R-HSA-68875 Mitotic Prophase 0.017868 1.748
R-HSA-1433557 Signaling by SCF-KIT 0.018815 1.726
R-HSA-6804757 Regulation of TP53 Degradation 0.013658 1.865
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.015508 1.809
R-HSA-162909 Host Interactions of HIV factors 0.019294 1.715
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.020214 1.694
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.020214 1.694
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 0.020214 1.694
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 0.020214 1.694
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.020929 1.679
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.021655 1.664
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.020929 1.679
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.020929 1.679
R-HSA-2514856 The phototransduction cascade 0.024661 1.608
R-HSA-9018519 Estrogen-dependent gene expression 0.025187 1.599
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.025437 1.595
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 0.026224 1.581
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 0.026224 1.581
R-HSA-8948751 Regulation of PTEN stability and activity 0.026224 1.581
R-HSA-445355 Smooth Muscle Contraction 0.026224 1.581
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.027827 1.556
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.028643 1.543
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.027021 1.568
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.031147 1.507
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.033735 1.472
R-HSA-194441 Metabolism of non-coding RNA 0.031147 1.507
R-HSA-191859 snRNP Assembly 0.031147 1.507
R-HSA-168325 Viral Messenger RNA Synthesis 0.032863 1.483
R-HSA-6784531 tRNA processing in the nucleus 0.033735 1.472
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.033893 1.470
R-HSA-114516 Disinhibition of SNARE formation 0.040170 1.396
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.041977 1.377
R-HSA-453276 Regulation of mitotic cell cycle 0.041977 1.377
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.043901 1.358
R-HSA-2467813 Separation of Sister Chromatids 0.039026 1.409
R-HSA-2470946 Cohesin Loading onto Chromatin 0.040170 1.396
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 0.040085 1.397
R-HSA-9010642 ROBO receptors bind AKAP5 0.044098 1.356
R-HSA-69052 Switching of origins to a post-replicative state 0.043901 1.358
R-HSA-5693606 DNA Double Strand Break Response 0.038227 1.418
R-HSA-167172 Transcription of the HIV genome 0.039152 1.407
R-HSA-5578749 Transcriptional regulation by small RNAs 0.042935 1.367
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.044876 1.348
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.048011 1.319
R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.040170 1.396
R-HSA-430116 GP1b-IX-V activation signalling 0.048011 1.319
R-HSA-4086400 PCP/CE pathway 0.048853 1.311
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.042935 1.367
R-HSA-1169408 ISG15 antiviral mechanism 0.045858 1.339
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 0.050888 1.293
R-HSA-380612 Metabolism of serotonin 0.051908 1.285
R-HSA-2179392 EGFR Transactivation by Gastrin 0.051908 1.285
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.051917 1.285
R-HSA-212165 Epigenetic regulation of gene expression 0.052431 1.280
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.052954 1.276
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.067339 1.172
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.071158 1.148
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.074961 1.125
R-HSA-176412 Phosphorylation of the APC/C 0.078749 1.104
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 0.078749 1.104
R-HSA-9912633 Antigen processing: Ub, ATP-independent proteasomal degradation 0.082522 1.083
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.093750 1.028
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.097462 1.011
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.101160 0.995
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.127188 0.896
R-HSA-9932444 ATP-dependent chromatin remodelers 0.119424 0.923
R-HSA-9932451 SWI/SNF chromatin remodelers 0.119424 0.923
R-HSA-69618 Mitotic Spindle Checkpoint 0.076315 1.117
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.086280 1.064
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 0.090023 1.046
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 0.104842 0.979
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.082522 1.083
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.126627 0.897
R-HSA-399719 Trafficking of AMPA receptors 0.140860 0.851
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.140860 0.851
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.156973 0.804
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 0.082522 1.083
R-HSA-4419969 Depolymerization of the Nuclear Lamina 0.090023 1.046
R-HSA-5218921 VEGFR2 mediated cell proliferation 0.119424 0.923
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.137323 0.862
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.144382 0.840
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.158330 0.800
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.158330 0.800
R-HSA-399997 Acetylcholine regulates insulin secretion 0.082522 1.083
R-HSA-4641258 Degradation of DVL 0.165219 0.782
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.124830 0.904
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.059654 1.224
R-HSA-380615 Serotonin clearance from the synaptic cleft 0.063504 1.197
R-HSA-432047 Passive transport by Aquaporins 0.082522 1.083
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.161781 0.791
R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.161781 0.791
R-HSA-4641257 Degradation of AXIN 0.165219 0.782
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.165219 0.782
R-HSA-69481 G2/M Checkpoints 0.115405 0.938
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.093750 1.028
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 0.147890 0.830
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.067339 1.172
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.067339 1.172
R-HSA-391160 Signal regulatory protein family interactions 0.071158 1.148
R-HSA-70350 Fructose catabolism 0.078749 1.104
R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.078749 1.104
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 0.123033 0.910
R-HSA-9675126 Diseases of mitotic cell cycle 0.144382 0.840
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.147890 0.830
R-HSA-180534 Vpu mediated degradation of CD4 0.151384 0.820
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.154864 0.810
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.154864 0.810
R-HSA-169911 Regulation of Apoptosis 0.158330 0.800
R-HSA-9837999 Mitochondrial protein degradation 0.068207 1.166
R-HSA-1592230 Mitochondrial biogenesis 0.101001 0.996
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.063504 1.197
R-HSA-9706369 Negative regulation of FLT3 0.078749 1.104
R-HSA-1250196 SHC1 events in ERBB2 signaling 0.137323 0.862
R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.093750 1.028
R-HSA-5652084 Fructose metabolism 0.108510 0.965
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.158406 0.800
R-HSA-3214847 HATs acetylate histones 0.075139 1.124
R-HSA-1483249 Inositol phosphate metabolism 0.092124 1.036
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.093750 1.028
R-HSA-5693532 DNA Double-Strand Break Repair 0.155544 0.808
R-HSA-3214842 HDMs demethylate histones 0.119424 0.923
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.137323 0.862
R-HSA-69239 Synthesis of DNA 0.085935 1.066
R-HSA-9610379 HCMV Late Events 0.161278 0.792
R-HSA-446353 Cell-extracellular matrix interactions 0.074961 1.125
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 0.154116 0.812
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 0.154864 0.810
R-HSA-69242 S Phase 0.148434 0.828
R-HSA-111933 Calmodulin induced events 0.161781 0.791
R-HSA-68867 Assembly of the pre-replicative complex 0.067074 1.173
R-HSA-70171 Glycolysis 0.076315 1.117
R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.090023 1.046
R-HSA-111997 CaM pathway 0.161781 0.791
R-HSA-9909396 Circadian clock 0.123472 0.908
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.078686 1.104
R-HSA-69306 DNA Replication 0.155544 0.808
R-HSA-8983711 OAS antiviral response 0.063504 1.197
R-HSA-3000170 Syndecan interactions 0.112163 0.950
R-HSA-74160 Gene expression (Transcription) 0.109024 0.962
R-HSA-112311 Neurotransmitter clearance 0.137323 0.862
R-HSA-69002 DNA Replication Pre-Initiation 0.088395 1.054
R-HSA-3858494 Beta-catenin independent WNT signaling 0.130297 0.885
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 0.154864 0.810
R-HSA-203615 eNOS activation 0.154864 0.810
R-HSA-70326 Glucose metabolism 0.101001 0.996
R-HSA-9824446 Viral Infection Pathways 0.096604 1.015
R-HSA-8939211 ESR-mediated signaling 0.088886 1.051
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.139998 0.854
R-HSA-8853659 RET signaling 0.161781 0.791
R-HSA-6807070 PTEN Regulation 0.134435 0.871
R-HSA-3371556 Cellular response to heat stress 0.106178 0.974
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 0.158330 0.800
R-HSA-211945 Phase I - Functionalization of compounds 0.123569 0.908
R-HSA-3700989 Transcriptional Regulation by TP53 0.138612 0.858
R-HSA-211000 Gene Silencing by RNA 0.085935 1.066
R-HSA-162582 Signal Transduction 0.062556 1.204
R-HSA-2187338 Visual phototransduction 0.147021 0.833
R-HSA-5619115 Disorders of transmembrane transporters 0.096915 1.014
R-HSA-1500931 Cell-Cell communication 0.159413 0.797
R-HSA-109581 Apoptosis 0.168501 0.773
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 0.168643 0.773
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.172053 0.764
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 0.172053 0.764
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.172053 0.764
R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.175449 0.756
R-HSA-8941858 Regulation of RUNX3 expression and activity 0.175449 0.756
R-HSA-5619102 SLC transporter disorders 0.175780 0.755
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.178832 0.748
R-HSA-5362768 Hh mutants are degraded by ERAD 0.178832 0.748
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 0.178832 0.748
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.178832 0.748
R-HSA-8853884 Transcriptional Regulation by VENTX 0.178832 0.748
R-HSA-9607240 FLT3 Signaling 0.178832 0.748
R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.178832 0.748
R-HSA-72306 tRNA processing 0.181640 0.741
R-HSA-9932298 Degradation of CRY and PER proteins 0.182201 0.739
R-HSA-5610780 Degradation of GLI1 by the proteasome 0.182201 0.739
R-HSA-5610783 Degradation of GLI2 by the proteasome 0.182201 0.739
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.182201 0.739
R-HSA-110329 Cleavage of the damaged pyrimidine 0.185556 0.732
R-HSA-73928 Depyrimidination 0.185556 0.732
R-HSA-111996 Ca-dependent events 0.185556 0.732
R-HSA-9006925 Intracellular signaling by second messengers 0.185585 0.731
R-HSA-5689880 Ub-specific processing proteases 0.186054 0.730
R-HSA-5387390 Hh mutants abrogate ligand secretion 0.188898 0.724
R-HSA-9907900 Proteasome assembly 0.192226 0.716
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.192226 0.716
R-HSA-3214858 RMTs methylate histone arginines 0.192226 0.716
R-HSA-168255 Influenza Infection 0.194930 0.710
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.195541 0.709
R-HSA-4608870 Asymmetric localization of PCP proteins 0.195541 0.709
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.195541 0.709
R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.195541 0.709
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.195541 0.709
R-HSA-1489509 DAG and IP3 signaling 0.195541 0.709
R-HSA-9824272 Somitogenesis 0.195541 0.709
R-HSA-73894 DNA Repair 0.204339 0.690
R-HSA-9766229 Degradation of CDH1 0.208666 0.681
R-HSA-5658442 Regulation of RAS by GAPs 0.211915 0.674
R-HSA-1169091 Activation of NF-kappaB in B cells 0.215150 0.667
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.215150 0.667
R-HSA-5358346 Hedgehog ligand biogenesis 0.215150 0.667
R-HSA-68949 Orc1 removal from chromatin 0.218372 0.661
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 0.218372 0.661
R-HSA-9609690 HCMV Early Events 0.220348 0.657
R-HSA-73929 Base-Excision Repair, AP Site Formation 0.224777 0.648
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.227960 0.642
R-HSA-3214815 HDACs deacetylate histones 0.227960 0.642
R-HSA-418597 G alpha (z) signalling events 0.227960 0.642
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.229999 0.638
R-HSA-913531 Interferon Signaling 0.229999 0.638
R-HSA-376176 Signaling by ROBO receptors 0.230903 0.637
R-HSA-193648 NRAGE signals death through JNK 0.231130 0.636
R-HSA-109606 Intrinsic Pathway for Apoptosis 0.231130 0.636
R-HSA-9764561 Regulation of CDH1 Function 0.234288 0.630
R-HSA-5357801 Programmed Cell Death 0.235438 0.628
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.243684 0.613
R-HSA-351202 Metabolism of polyamines 0.243684 0.613
R-HSA-1227986 Signaling by ERBB2 0.243684 0.613
R-HSA-397014 Muscle contraction 0.246040 0.609
R-HSA-445717 Aquaporin-mediated transport 0.246791 0.608
R-HSA-8939902 Regulation of RUNX2 expression and activity 0.246791 0.608
R-HSA-112043 PLC beta mediated events 0.246791 0.608
R-HSA-9793380 Formation of paraxial mesoderm 0.246791 0.608
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.249885 0.602
R-HSA-9707616 Heme signaling 0.249885 0.602
R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.252966 0.597
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.259092 0.587
R-HSA-1234174 Cellular response to hypoxia 0.259092 0.587
R-HSA-8951664 Neddylation 0.259700 0.586
R-HSA-112040 G-protein mediated events 0.265169 0.576
R-HSA-73857 RNA Polymerase II Transcription 0.267213 0.573
R-HSA-8878171 Transcriptional regulation by RUNX1 0.267296 0.573
R-HSA-9705683 SARS-CoV-2-host interactions 0.270335 0.568
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.274191 0.562
R-HSA-69202 Cyclin E associated events during G1/S transition 0.274191 0.562
R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.274191 0.562
R-HSA-427413 NoRC negatively regulates rRNA expression 0.277175 0.557
R-HSA-5632684 Hedgehog 'on' state 0.277175 0.557
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.280146 0.553
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.283105 0.548
R-HSA-4086398 Ca2+ pathway 0.283105 0.548
R-HSA-1266738 Developmental Biology 0.283561 0.547
R-HSA-69473 G2/M DNA damage checkpoint 0.286052 0.544
R-HSA-9013694 Signaling by NOTCH4 0.286052 0.544
R-HSA-8852135 Protein ubiquitination 0.288987 0.539
R-HSA-3000171 Non-integrin membrane-ECM interactions 0.288987 0.539
R-HSA-5689603 UCH proteinases 0.291910 0.535
R-HSA-383280 Nuclear Receptor transcription pathway 0.297722 0.526
R-HSA-416482 G alpha (12/13) signalling events 0.297722 0.526
R-HSA-5619084 ABC transporter disorders 0.297722 0.526
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.300610 0.522
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.303486 0.518
R-HSA-9609646 HCMV Infection 0.303720 0.518
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.309204 0.510
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.309826 0.509
R-HSA-5688426 Deubiquitination 0.311281 0.507
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.312045 0.506
R-HSA-9707564 Cytoprotection by HMOX1 0.312045 0.506
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.314875 0.502
R-HSA-212436 Generic Transcription Pathway 0.315143 0.501
R-HSA-6802957 Oncogenic MAPK signaling 0.317693 0.498
R-HSA-5687128 MAPK6/MAPK4 signaling 0.317693 0.498
R-HSA-141424 Amplification of signal from the kinetochores 0.320500 0.494
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.320500 0.494
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 0.320500 0.494
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.320500 0.494
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.323296 0.490
R-HSA-9711123 Cellular response to chemical stress 0.330862 0.480
R-HSA-1236974 ER-Phagosome pathway 0.331615 0.479
R-HSA-73884 Base Excision Repair 0.334366 0.476
R-HSA-202424 Downstream TCR signaling 0.334366 0.476
R-HSA-76002 Platelet activation, signaling and aggregation 0.339853 0.469
R-HSA-446728 Cell junction organization 0.345828 0.461
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.347319 0.459
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 0.353311 0.452
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.355973 0.449
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.355973 0.449
R-HSA-8878159 Transcriptional regulation by RUNX3 0.358625 0.445
R-HSA-422356 Regulation of insulin secretion 0.361266 0.442
R-HSA-193704 p75 NTR receptor-mediated signalling 0.363897 0.439
R-HSA-5610787 Hedgehog 'off' state 0.366517 0.436
R-HSA-382556 ABC-family proteins mediated transport 0.366517 0.436
R-HSA-9020702 Interleukin-1 signaling 0.369126 0.433
R-HSA-1257604 PIP3 activates AKT signaling 0.371024 0.431
R-HSA-9842860 Regulation of endogenous retroelements 0.371724 0.430
R-HSA-195721 Signaling by WNT 0.375433 0.425
R-HSA-111885 Opioid Signalling 0.376890 0.424
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.377321 0.423
R-HSA-9833110 RSV-host interactions 0.379457 0.421
R-HSA-211859 Biological oxidations 0.386265 0.413
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.387096 0.412
R-HSA-9700206 Signaling by ALK in cancer 0.387096 0.412
R-HSA-1236975 Antigen processing-Cross presentation 0.389621 0.409
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.392137 0.407
R-HSA-202403 TCR signaling 0.394642 0.404
R-HSA-5663205 Infectious disease 0.403782 0.394
R-HSA-1852241 Organelle biogenesis and maintenance 0.407380 0.390
R-HSA-112315 Transmission across Chemical Synapses 0.411679 0.385
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.411895 0.385
R-HSA-9007101 Rab regulation of trafficking 0.416735 0.380
R-HSA-8878166 Transcriptional regulation by RUNX2 0.421536 0.375
R-HSA-9679506 SARS-CoV Infections 0.421735 0.375
R-HSA-2262752 Cellular responses to stress 0.423152 0.374
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.426298 0.370
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.426298 0.370
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.431021 0.366
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.438035 0.358
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.438035 0.358
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.438035 0.358
R-HSA-194138 Signaling by VEGF 0.438035 0.358
R-HSA-69206 G1/S Transition 0.438035 0.358
R-HSA-114608 Platelet degranulation 0.442663 0.354
R-HSA-1280218 Adaptive Immune System 0.446106 0.351
R-HSA-9694516 SARS-CoV-2 Infection 0.448290 0.348
R-HSA-9843745 Adipogenesis 0.454069 0.343
R-HSA-8856688 Golgi-to-ER retrograde transport 0.456323 0.341
R-HSA-163685 Integration of energy metabolism 0.467454 0.330
R-HSA-8953854 Metabolism of RNA 0.468165 0.330
R-HSA-1280215 Cytokine Signaling in Immune system 0.468863 0.329
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 0.469653 0.328
R-HSA-9948299 Ribosome-associated quality control 0.471843 0.326
R-HSA-5358351 Signaling by Hedgehog 0.471843 0.326
R-HSA-2871837 FCERI mediated NF-kB activation 0.486927 0.313
R-HSA-71291 Metabolism of amino acids and derivatives 0.489464 0.310
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.491159 0.309
R-HSA-9758941 Gastrulation 0.497441 0.303
R-HSA-9856651 MITF-M-dependent gene expression 0.499518 0.301
R-HSA-9679191 Potential therapeutics for SARS 0.499518 0.301
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.501587 0.300
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.503647 0.298
R-HSA-446652 Interleukin-1 family signaling 0.503647 0.298
R-HSA-73887 Death Receptor Signaling 0.507743 0.294
R-HSA-1989781 PPARA activates gene expression 0.509778 0.293
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.513823 0.289
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.515834 0.287
R-HSA-8953897 Cellular responses to stimuli 0.525268 0.280
R-HSA-5621481 C-type lectin receptors (CLRs) 0.543135 0.265
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.545026 0.264
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.546909 0.262
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.546909 0.262
R-HSA-2559583 Cellular Senescence 0.559879 0.252
R-HSA-201681 TCF dependent signaling in response to WNT 0.565325 0.248
R-HSA-69275 G2/M Transition 0.570705 0.244
R-HSA-453274 Mitotic G2-G2/M phases 0.574255 0.241
R-HSA-68877 Mitotic Prometaphase 0.583003 0.234
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.588167 0.230
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.594955 0.226
R-HSA-389948 Co-inhibition by PD-1 0.594955 0.226
R-HSA-112316 Neuronal System 0.599318 0.222
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.599973 0.222
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 0.616262 0.210
R-HSA-9730414 MITF-M-regulated melanocyte development 0.617854 0.209
R-HSA-418990 Adherens junctions interactions 0.625720 0.204
R-HSA-157118 Signaling by NOTCH 0.658476 0.181
R-HSA-421270 Cell-cell junction organization 0.673778 0.171
R-HSA-422475 Axon guidance 0.679066 0.168
R-HSA-388841 Regulation of T cell activation by CD28 family 0.680508 0.167
R-HSA-416476 G alpha (q) signalling events 0.690994 0.161
R-HSA-597592 Post-translational protein modification 0.698200 0.156
R-HSA-9675108 Nervous system development 0.712643 0.147
R-HSA-5673001 RAF/MAP kinase cascade 0.721624 0.142
R-HSA-5684996 MAPK1/MAPK3 signaling 0.729650 0.137
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.738513 0.132
R-HSA-1643685 Disease 0.755001 0.122
R-HSA-8957322 Metabolism of steroids 0.759540 0.119
R-HSA-1474244 Extracellular matrix organization 0.766489 0.115
R-HSA-5683057 MAPK family signaling cascades 0.781637 0.107
R-HSA-392499 Metabolism of proteins 0.798038 0.098
R-HSA-168256 Immune System 0.830587 0.081
R-HSA-418594 G alpha (i) signalling events 0.831014 0.080
R-HSA-388396 GPCR downstream signalling 0.843347 0.074
R-HSA-72766 Translation 0.845975 0.073
R-HSA-109582 Hemostasis 0.848421 0.071
R-HSA-6798695 Neutrophil degranulation 0.863141 0.064
R-HSA-372790 Signaling by GPCR 0.881224 0.055
R-HSA-382551 Transport of small molecules 0.922508 0.035
R-HSA-1430728 Metabolism 0.928834 0.032
R-HSA-449147 Signaling by Interleukins 0.932947 0.030
R-HSA-199991 Membrane Trafficking 0.939224 0.027
R-HSA-9709957 Sensory Perception 0.969272 0.014
R-HSA-5653656 Vesicle-mediated transport 0.969448 0.013
R-HSA-168249 Innate Immune System 0.996908 0.001
R-HSA-556833 Metabolism of lipids 0.998488 0.001
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GAKGAK 0.765 0.017 1 0.647
GCKGCK 0.759 0.083 1 0.678
DAPK2DAPK2 0.759 0.170 -3 0.667
DAPK3DAPK3 0.758 0.175 -3 0.674
TAK1TAK1 0.758 -0.043 1 0.682
KHS1KHS1 0.756 0.081 1 0.654
KHS2KHS2 0.755 0.092 1 0.674
HPK1HPK1 0.754 0.084 1 0.678
BRAFBRAF 0.754 0.023 -4 0.794
DMPK1DMPK1 0.754 0.160 -3 0.694
TNIKTNIK 0.753 0.005 3 0.552
NIKNIK 0.751 0.125 -3 0.683
MINKMINK 0.751 -0.035 1 0.656
PKRPKR 0.750 -0.044 1 0.646
CAMLCKCAMLCK 0.750 0.102 -2 0.853
MEK1MEK1 0.750 -0.038 2 0.644
SMMLCKSMMLCK 0.749 0.102 -3 0.650
LKB1LKB1 0.748 -0.031 -3 0.573
NEK1NEK1 0.748 -0.088 1 0.620
TAO2TAO2 0.748 0.005 2 0.653
CAMK1BCAMK1B 0.747 0.156 -3 0.687
VRK2VRK2 0.747 -0.233 1 0.673
DAPK1DAPK1 0.747 0.149 -3 0.648
LRRK2LRRK2 0.746 -0.093 2 0.640
ASK1ASK1 0.746 -0.111 1 0.607
SKMLCKSKMLCK 0.746 0.228 -2 0.869
LATS1LATS1 0.745 0.122 -3 0.637
HGKHGK 0.745 -0.052 3 0.547
MST3MST3 0.745 0.035 2 0.670
TAO3TAO3 0.744 0.059 1 0.650
ALK4ALK4 0.744 0.006 -2 0.762
MST1MST1 0.744 -0.070 1 0.649
ROCK2ROCK2 0.744 0.128 -3 0.661
PDK1PDK1 0.743 -0.053 1 0.651
PASKPASK 0.743 0.078 -3 0.617
MST2MST2 0.743 -0.084 1 0.663
BMPR2BMPR2 0.743 -0.137 -2 0.809
BMPR1BBMPR1B 0.742 0.128 1 0.715
VRK1VRK1 0.742 -0.193 2 0.625
NEK5NEK5 0.742 -0.097 1 0.640
TTKTTK 0.742 -0.085 -2 0.755
ALK2ALK2 0.742 0.046 -2 0.737
MEKK6MEKK6 0.741 -0.084 1 0.632
MAP3K15MAP3K15 0.741 -0.092 1 0.614
MOSMOS 0.741 0.075 1 0.732
TGFBR1TGFBR1 0.740 0.058 -2 0.731
NEK4NEK4 0.739 -0.090 1 0.627
JNK2JNK2 0.739 0.052 1 0.509
CAMKK2CAMKK2 0.739 -0.092 -2 0.706
EEF2KEEF2K 0.739 -0.096 3 0.527
MEK2MEK2 0.738 -0.145 2 0.598
NEK11NEK11 0.738 -0.081 1 0.657
PBKPBK 0.737 -0.030 1 0.562
MEK5MEK5 0.737 -0.186 2 0.622
PRPKPRPK 0.737 -0.058 -1 0.838
MEKK2MEKK2 0.736 -0.143 2 0.597
YSK1YSK1 0.736 -0.064 2 0.622
MYO3BMYO3B 0.736 -0.092 2 0.630
CAMKK1CAMKK1 0.736 -0.139 -2 0.712
MYO3AMYO3A 0.736 -0.084 1 0.612
BIKEBIKE 0.736 -0.066 1 0.514
ANKRD3ANKRD3 0.735 -0.099 1 0.680
DLKDLK 0.735 -0.069 1 0.681
LOKLOK 0.735 0.017 -2 0.732
ALPHAK3ALPHAK3 0.734 -0.075 -1 0.729
NEK8NEK8 0.734 -0.130 2 0.609
BMPR1ABMPR1A 0.733 0.101 1 0.691
YSK4YSK4 0.733 -0.064 1 0.642
RAF1RAF1 0.733 0.079 1 0.700
ATRATR 0.733 -0.005 1 0.672
JNK3JNK3 0.733 0.025 1 0.535
CDKL1CDKL1 0.732 -0.005 -3 0.595
ROCK1ROCK1 0.732 0.110 -3 0.657
PIM1PIM1 0.732 0.129 -3 0.636
MRCKAMRCKA 0.731 0.127 -3 0.660
ICKICK 0.731 0.011 -3 0.618
CHK1CHK1 0.731 0.160 -3 0.670
TSSK2TSSK2 0.731 0.141 -5 0.774
ACVR2BACVR2B 0.731 0.023 -2 0.737
MEKK3MEKK3 0.730 -0.109 1 0.646
AMPKA1AMPKA1 0.729 0.180 -3 0.695
DCAMKL1DCAMKL1 0.729 0.153 -3 0.697
NLKNLK 0.729 -0.032 1 0.670
CAMK2GCAMK2G 0.729 0.045 2 0.697
MPSK1MPSK1 0.728 -0.083 1 0.565
P38AP38A 0.728 0.002 1 0.567
TSSK1TSSK1 0.728 0.206 -3 0.707
MYLK4MYLK4 0.728 0.146 -2 0.825
MEKK1MEKK1 0.728 -0.188 1 0.625
GRK6GRK6 0.728 0.097 1 0.705
STLK3STLK3 0.727 -0.174 1 0.598
CDC7CDC7 0.727 0.170 1 0.743
DNAPKDNAPK 0.727 0.056 1 0.597
ACVR2AACVR2A 0.727 0.009 -2 0.715
CLK3CLK3 0.727 0.160 1 0.680
MRCKBMRCKB 0.726 0.111 -3 0.655
NUAK2NUAK2 0.726 0.171 -3 0.700
ZAKZAK 0.726 -0.150 1 0.625
OSR1OSR1 0.726 -0.147 2 0.602
CRIKCRIK 0.725 0.071 -3 0.589
PIM2PIM2 0.725 0.081 -3 0.634
PDHK4PDHK4 0.725 -0.018 1 0.704
P38BP38B 0.725 0.006 1 0.526
CAMK1DCAMK1D 0.725 0.145 -3 0.642
AAK1AAK1 0.725 -0.049 1 0.423
CAMK2DCAMK2D 0.725 0.133 -3 0.652
MST4MST4 0.725 0.135 2 0.738
PKN3PKN3 0.724 0.050 -3 0.631
WNK1WNK1 0.724 0.115 -2 0.847
P70S6KBP70S6KB 0.724 0.105 -3 0.662
PIM3PIM3 0.724 0.118 -3 0.634
AKT2AKT2 0.724 0.107 -3 0.604
CLK4CLK4 0.723 0.126 -3 0.653
TAO1TAO1 0.723 -0.038 1 0.579
MLK2MLK2 0.723 -0.122 2 0.622
PDHK1PDHK1 0.723 0.033 1 0.689
DCAMKL2DCAMKL2 0.723 0.113 -3 0.731
CAMK2BCAMK2B 0.723 0.185 2 0.719
SLKSLK 0.722 0.005 -2 0.657
AMPKA2AMPKA2 0.722 0.179 -3 0.690
PLK1PLK1 0.722 -0.015 -2 0.747
ERK5ERK5 0.722 -0.000 1 0.668
DRAK1DRAK1 0.721 0.056 1 0.703
CAMK2ACAMK2A 0.721 0.188 2 0.719
WNK4WNK4 0.720 -0.031 -2 0.829
MARK4MARK4 0.720 0.131 4 0.750
HIPK1HIPK1 0.720 0.037 1 0.544
PRP4PRP4 0.719 -0.074 -3 0.479
HUNKHUNK 0.719 0.088 2 0.600
SGK3SGK3 0.719 0.105 -3 0.625
NEK2NEK2 0.719 -0.065 2 0.598
PKN2PKN2 0.718 0.091 -3 0.675
PKCDPKCD 0.718 0.064 2 0.599
GRK5GRK5 0.717 -0.026 -3 0.581
GRK7GRK7 0.717 0.049 1 0.642
SGK1SGK1 0.717 0.080 -3 0.519
MASTLMASTL 0.717 -0.154 -2 0.765
RIPK3RIPK3 0.717 -0.015 3 0.533
NEK9NEK9 0.717 -0.134 2 0.635
CHK2CHK2 0.716 0.071 -3 0.589
MARK1MARK1 0.716 0.199 4 0.717
RSK2RSK2 0.716 0.127 -3 0.631
PERKPERK 0.716 -0.181 -2 0.766
DSTYKDSTYK 0.716 -0.047 2 0.736
COTCOT 0.716 0.015 2 0.710
CAMK4CAMK4 0.716 0.141 -3 0.699
MELKMELK 0.715 0.128 -3 0.688
MSK1MSK1 0.715 0.123 -3 0.573
HRIHRI 0.715 -0.182 -2 0.784
TLK2TLK2 0.715 -0.077 1 0.618
RIPK1RIPK1 0.715 -0.103 1 0.627
ATMATM 0.715 0.017 1 0.621
SBKSBK 0.715 0.083 -3 0.532
PLK3PLK3 0.714 -0.009 2 0.626
DYRK1ADYRK1A 0.714 0.024 1 0.584
CLK1CLK1 0.714 0.133 -3 0.672
MARK2MARK2 0.713 0.145 4 0.660
DYRK2DYRK2 0.713 0.024 1 0.532
ERK2ERK2 0.713 -0.031 1 0.550
TLK1TLK1 0.713 -0.109 -2 0.765
AKT1AKT1 0.712 0.110 -3 0.622
MAKMAK 0.712 0.019 -2 0.684
PAK1PAK1 0.712 0.116 -2 0.823
PRKD3PRKD3 0.712 0.101 -3 0.643
IRAK4IRAK4 0.711 -0.109 1 0.601
MLK1MLK1 0.711 -0.150 2 0.638
BUB1BUB1 0.711 -0.020 -5 0.723
NEK3NEK3 0.711 -0.165 1 0.589
JNK1JNK1 0.710 0.002 1 0.504
PAK2PAK2 0.710 0.065 -2 0.809
CDKL5CDKL5 0.710 -0.009 -3 0.589
PRKD1PRKD1 0.710 0.141 -3 0.614
P90RSKP90RSK 0.710 0.070 -3 0.606
QSKQSK 0.710 0.149 4 0.725
P38DP38D 0.710 0.004 1 0.448
AURBAURB 0.710 0.128 -2 0.707
MTORMTOR 0.710 -0.026 1 0.646
HIPK3HIPK3 0.709 0.004 1 0.545
HASPINHASPIN 0.709 -0.029 -1 0.646
GRK2GRK2 0.709 0.003 -2 0.654
P38GP38G 0.709 -0.003 1 0.443
SSTKSSTK 0.709 0.127 4 0.755
WNK3WNK3 0.709 -0.020 1 0.647
QIKQIK 0.708 0.102 -3 0.674
MARK3MARK3 0.708 0.166 4 0.697
MAPKAPK3MAPKAPK3 0.708 0.110 -3 0.631
CAMK1ACAMK1A 0.708 0.103 -3 0.600
MOKMOK 0.708 0.004 1 0.554
PRKD2PRKD2 0.707 0.166 -3 0.663
PAK3PAK3 0.707 0.095 -2 0.826
SIKSIK 0.706 0.164 -3 0.660
SMG1SMG1 0.706 -0.031 1 0.625
CLK2CLK2 0.705 0.140 -3 0.637
CAMK1GCAMK1G 0.705 0.054 -3 0.643
PKACBPKACB 0.705 0.172 -2 0.728
AURAAURA 0.705 0.125 -2 0.683
CDK14CDK14 0.705 0.001 1 0.513
NUAK1NUAK1 0.705 0.130 -3 0.688
DYRK4DYRK4 0.704 0.050 1 0.483
ERK1ERK1 0.704 -0.019 1 0.512
ERK7ERK7 0.704 -0.044 2 0.392
DYRK1BDYRK1B 0.704 0.027 1 0.497
TGFBR2TGFBR2 0.704 -0.059 -2 0.729
DYRK3DYRK3 0.703 0.034 1 0.534
TBK1TBK1 0.703 -0.033 1 0.621
HIPK4HIPK4 0.703 0.019 1 0.609
RSK4RSK4 0.703 0.108 -3 0.603
GSK3BGSK3B 0.703 -0.010 4 0.431
MLK3MLK3 0.703 -0.086 2 0.573
PINK1PINK1 0.703 -0.186 1 0.627
MSK2MSK2 0.703 0.064 -3 0.554
NDR1NDR1 0.703 0.085 -3 0.664
CDK5CDK5 0.703 -0.025 1 0.547
BCKDKBCKDK 0.702 0.142 -1 0.850
SRPK1SRPK1 0.702 0.026 -3 0.576
CHAK2CHAK2 0.702 -0.123 -1 0.809
IRAK1IRAK1 0.702 -0.159 -1 0.768
PKCHPKCH 0.701 0.010 2 0.525
PLK2PLK2 0.701 -0.015 -3 0.532
PKCAPKCA 0.701 0.009 2 0.543
MNK2MNK2 0.700 0.147 -2 0.814
PKCBPKCB 0.700 0.032 2 0.559
MAPKAPK2MAPKAPK2 0.700 0.143 -3 0.598
PKACGPKACG 0.700 0.110 -2 0.765
RIPK2RIPK2 0.700 -0.153 1 0.593
PKCZPKCZ 0.700 -0.007 2 0.566
CDK1CDK1 0.700 -0.013 1 0.520
LATS2LATS2 0.700 0.117 -5 0.661
RSK3RSK3 0.700 0.075 -3 0.613
NEK7NEK7 0.700 -0.147 -3 0.551
MLK4MLK4 0.699 -0.146 2 0.541
NIM1NIM1 0.699 -0.003 3 0.569
GSK3AGSK3A 0.699 0.003 4 0.439
PKG2PKG2 0.699 0.116 -2 0.715
MNK1MNK1 0.699 0.146 -2 0.824
CK2A2CK2A2 0.698 0.131 1 0.703
AURCAURC 0.698 0.157 -2 0.706
NDR2NDR2 0.698 0.145 -3 0.650
SRPK3SRPK3 0.698 -0.020 -3 0.543
HIPK2HIPK2 0.698 0.047 1 0.462
PAK6PAK6 0.698 0.213 -2 0.759
GRK1GRK1 0.697 0.046 -2 0.734
IKKEIKKE 0.696 -0.052 1 0.626
ULK2ULK2 0.696 -0.167 2 0.565
P70S6KP70S6K 0.696 0.039 -3 0.584
NEK6NEK6 0.696 -0.092 -2 0.782
PKACAPKACA 0.696 0.147 -2 0.680
IKKBIKKB 0.696 0.007 -2 0.713
CDK16CDK16 0.695 0.004 1 0.455
CDK2CDK2 0.695 -0.057 1 0.581
PKCEPKCE 0.695 0.036 2 0.538
CHAK1CHAK1 0.695 -0.156 2 0.534
BRSK1BRSK1 0.695 0.175 -3 0.664
CDK4CDK4 0.695 -0.029 1 0.487
CDK17CDK17 0.695 -0.008 1 0.443
IKKAIKKA 0.694 0.046 -2 0.684
CDK7CDK7 0.694 -0.004 1 0.542
AKT3AKT3 0.694 0.074 -3 0.531
FAM20CFAM20C 0.693 0.147 2 0.642
PDHK3_TYRPDHK3_TYR 0.693 0.147 4 0.795
PKCGPKCG 0.693 0.019 2 0.555
IRE2IRE2 0.693 -0.125 2 0.533
PKCIPKCI 0.693 -0.002 2 0.545
GRK4GRK4 0.693 -0.066 -2 0.769
CDK18CDK18 0.692 -0.001 1 0.481
PKCTPKCT 0.692 0.003 2 0.531
CDK6CDK6 0.691 -0.049 1 0.491
CK2A1CK2A1 0.691 0.110 1 0.699
IRE1IRE1 0.691 -0.126 1 0.586
PKN1PKN1 0.689 0.034 -3 0.623
CDK3CDK3 0.689 -0.014 1 0.461
CDK10CDK10 0.689 0.010 1 0.500
PRKXPRKX 0.688 0.198 -3 0.636
CDK9CDK9 0.688 -0.030 1 0.523
CDK13CDK13 0.688 -0.045 1 0.519
TTBK2TTBK2 0.688 -0.163 2 0.494
PHKG1PHKG1 0.687 0.036 -3 0.678
CDK8CDK8 0.687 -0.030 1 0.525
PLK4PLK4 0.687 -0.094 2 0.417
PDHK4_TYRPDHK4_TYR 0.686 0.088 2 0.726
BRSK2BRSK2 0.686 0.095 -3 0.694
SRPK2SRPK2 0.686 0.022 -3 0.531
CDK12CDK12 0.685 -0.042 1 0.499
TESK1_TYRTESK1_TYR 0.685 0.008 3 0.601
MAP2K6_TYRMAP2K6_TYR 0.684 0.028 -1 0.850
ULK1ULK1 0.684 -0.160 -3 0.540
DDR1DDR1 0.682 0.078 4 0.785
GRK3GRK3 0.682 -0.006 -2 0.615
MAP2K4_TYRMAP2K4_TYR 0.682 -0.025 -1 0.847
SNRKSNRK 0.681 -0.035 2 0.459
PHKG2PHKG2 0.680 0.111 -3 0.736
CK1DCK1D 0.679 -0.056 -3 0.304
PDHK1_TYRPDHK1_TYR 0.678 -0.016 -1 0.847
BMPR2_TYRBMPR2_TYR 0.678 -0.014 -1 0.802
GCN2GCN2 0.678 -0.193 2 0.610
MAP2K7_TYRMAP2K7_TYR 0.678 -0.109 2 0.675
STK33STK33 0.678 -0.163 2 0.424
PAK5PAK5 0.677 0.135 -2 0.693
EPHA6EPHA6 0.677 -0.014 -1 0.812
LIMK2_TYRLIMK2_TYR 0.677 0.008 -3 0.662
MAPKAPK5MAPKAPK5 0.675 -0.052 -3 0.529
RETRET 0.675 -0.067 1 0.638
PKMYT1_TYRPKMYT1_TYR 0.675 -0.140 3 0.588
EPHB4EPHB4 0.674 -0.049 -1 0.838
PINK1_TYRPINK1_TYR 0.674 -0.130 1 0.678
CDK19CDK19 0.672 -0.030 1 0.491
CK1A2CK1A2 0.672 -0.063 -3 0.315
INSRRINSRR 0.671 -0.046 3 0.543
MST1RMST1R 0.671 -0.112 3 0.582
TTBK1TTBK1 0.671 -0.142 2 0.425
TYRO3TYRO3 0.671 -0.116 3 0.551
SRMSSRMS 0.670 -0.036 1 0.709
TYK2TYK2 0.670 -0.139 1 0.632
ROS1ROS1 0.669 -0.114 3 0.530
CK1ECK1E 0.668 -0.057 -3 0.344
EPHA4EPHA4 0.668 -0.043 2 0.640
CSF1RCSF1R 0.668 -0.117 3 0.567
DDR2DDR2 0.668 0.055 3 0.543
LIMK1_TYRLIMK1_TYR 0.667 -0.153 2 0.645
EPHB1EPHB1 0.667 -0.058 1 0.695
YES1YES1 0.667 -0.081 -1 0.821
PAK4PAK4 0.667 0.121 -2 0.693
JAK2JAK2 0.666 -0.162 1 0.638
NEK10_TYRNEK10_TYR 0.665 -0.031 1 0.595
YANK3YANK3 0.665 -0.093 2 0.301
TXKTXK 0.665 -0.011 1 0.732
PKG1PKG1 0.665 0.079 -2 0.652
ABL2ABL2 0.665 -0.089 -1 0.784
FERFER 0.665 -0.122 1 0.715
EPHB3EPHB3 0.664 -0.069 -1 0.830
EPHB2EPHB2 0.664 -0.064 -1 0.822
AXLAXL 0.664 -0.064 3 0.584
TNK2TNK2 0.664 -0.073 3 0.568
JAK3JAK3 0.664 -0.125 1 0.632
FGFR2FGFR2 0.664 -0.096 3 0.592
FGRFGR 0.663 -0.123 1 0.681
FGFR1FGFR1 0.662 -0.110 3 0.573
ABL1ABL1 0.660 -0.107 -1 0.781
MERTKMERTK 0.660 -0.075 3 0.574
KITKIT 0.660 -0.126 3 0.570
PTK2BPTK2B 0.659 -0.017 -1 0.781
HCKHCK 0.659 -0.140 -1 0.776
EPHA3EPHA3 0.659 -0.070 2 0.599
BLKBLK 0.659 -0.077 -1 0.777
TEKTEK 0.659 -0.147 3 0.521
TNK1TNK1 0.658 -0.077 3 0.532
EPHA7EPHA7 0.658 -0.059 2 0.612
KDRKDR 0.658 -0.104 3 0.553
LCKLCK 0.658 -0.107 -1 0.769
TNNI3K_TYRTNNI3K_TYR 0.658 -0.084 1 0.610
JAK1JAK1 0.658 -0.104 1 0.591
FLT3FLT3 0.657 -0.154 3 0.546
TECTEC 0.657 -0.080 -1 0.717
LTKLTK 0.657 -0.083 3 0.528
PDGFRBPDGFRB 0.657 -0.154 3 0.564
EPHA5EPHA5 0.657 -0.037 2 0.620
FGFR3FGFR3 0.657 -0.091 3 0.581
ALKALK 0.657 -0.099 3 0.509
EPHA1EPHA1 0.655 -0.094 3 0.559
ITKITK 0.655 -0.117 -1 0.771
METMET 0.655 -0.116 3 0.569
NTRK2NTRK2 0.655 -0.124 3 0.573
BMXBMX 0.655 -0.073 -1 0.686
INSRINSR 0.654 -0.105 3 0.518
NTRK1NTRK1 0.654 -0.130 -1 0.816
YANK2YANK2 0.653 -0.114 2 0.312
KISKIS 0.653 -0.030 1 0.551
FYNFYN 0.650 -0.086 -1 0.728
PDGFRAPDGFRA 0.650 -0.195 3 0.559
ERBB2ERBB2 0.649 -0.151 1 0.613
BTKBTK 0.648 -0.186 -1 0.747
NTRK3NTRK3 0.648 -0.112 -1 0.777
EPHA8EPHA8 0.647 -0.093 -1 0.773
LYNLYN 0.647 -0.143 3 0.496
FLT4FLT4 0.647 -0.152 3 0.544
WEE1_TYRWEE1_TYR 0.647 -0.126 -1 0.745
PTK6PTK6 0.646 -0.167 -1 0.726
FRKFRK 0.646 -0.142 -1 0.783
CK1G3CK1G3 0.645 -0.045 -3 0.207
PTK2PTK2 0.645 -0.023 -1 0.680
FLT1FLT1 0.645 -0.144 -1 0.767
FGFR4FGFR4 0.642 -0.096 -1 0.755
EGFREGFR 0.642 -0.088 1 0.538
CSKCSK 0.642 -0.124 2 0.611
SRCSRC 0.642 -0.124 -1 0.750
EPHA2EPHA2 0.642 -0.082 -1 0.730
CK1G1CK1G1 0.640 -0.079 -3 0.338
MATKMATK 0.639 -0.138 -1 0.730
IGF1RIGF1R 0.637 -0.120 3 0.478
SYKSYK 0.636 -0.067 -1 0.684
ERBB4ERBB4 0.634 -0.084 1 0.567
MUSKMUSK 0.629 -0.145 1 0.517
FESFES 0.625 -0.119 -1 0.679
CK1ACK1A 0.611 -0.063 -3 0.239
ZAP70ZAP70 0.610 -0.105 -1 0.630
CK1G2CK1G2 0.603 -0.102 -3 0.278