Motif 1109 (n=60)
Position-wise Probabilities
Download
uniprot | genes | site | source | protein | function |
---|---|---|---|---|---|
A6NKT7 | RGPD3 | T1017 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
K7N7A8 | None | T426 | ochoa | Ubiquitin carboxyl-terminal hydrolase MINDY (EC 3.4.19.12) | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo. {ECO:0000256|ARBA:ARBA00049627}.; FUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000256|RuleBase:RU367088}.; FUNCTION: Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. {ECO:0000256|ARBA:ARBA00037630}. |
O14544 | SOCS6 | T93 | ochoa | Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4) | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}. |
O14715 | RGPD8 | T1016 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
O75128 | COBL | T434 | ochoa | Protein cordon-bleu | Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}. |
O75179 | ANKRD17 | T1565 | ochoa | Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
O75563 | SKAP2 | T290 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
O94788 | ALDH1A2 | T284 | ochoa | Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) | Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:29240402, PubMed:33565183). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable) (PubMed:33565183). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity). {ECO:0000250|UniProtKB:Q63639, ECO:0000269|PubMed:29240402, ECO:0000269|PubMed:33565183, ECO:0000305|PubMed:22075477}. |
O94876 | TMCC1 | T451 | ochoa | Transmembrane and coiled-coil domains protein 1 | Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). {ECO:0000269|PubMed:30220460}. |
O94953 | KDM4B | T305 | psp | Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
O96017 | CHEK2 | T205 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
P00352 | ALDH1A1 | T267 | ochoa|psp | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) | Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:19296407, PubMed:25450233, PubMed:26373694). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:12941160, PubMed:15623782, PubMed:19296407). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:12941160, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:17175089, ECO:0000269|PubMed:19296407, ECO:0000269|PubMed:25450233, ECO:0000269|PubMed:26373694}. |
P05091 | ALDH2 | T283 | ochoa | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. {ECO:0000269|PubMed:33355142}. |
P08133 | ANXA6 | T309 | ochoa | Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) | May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. |
P0DJD0 | RGPD1 | T1001 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
P0DJD1 | RGPD2 | T1009 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
P12532 | CKMT1A | T142 | ochoa | Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
P17252 | PRKCA | T228 | ochoa|psp | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:21806543, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:36040231, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. |
P17540 | CKMT2 | T143 | ochoa | Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
P20290 | BTF3 | T82 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
P21333 | FLNA | T915 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P28066 | PSMA5 | T55 | ochoa | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
P29972 | AQP1 | T246 | ochoa | Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel) | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:16682607, ECO:0000269|PubMed:17012249, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:33028705, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:36949749, ECO:0000269|PubMed:8584435, ECO:0000269|PubMed:8703053}. |
P30837 | ALDH1B1 | T283 | ochoa | Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) | ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. |
P47895 | ALDH1A3 | T278 | ochoa | Retinaldehyde dehydrogenase 3 (RALDH-3) (RalDH3) (EC 1.2.1.36) (Aldehyde dehydrogenase 6) (Aldehyde dehydrogenase family 1 member A3) (ALDH1A3) | Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity). {ECO:0000250|UniProtKB:Q9JHW9, ECO:0000269|PubMed:27759097}. |
P49792 | RANBP2 | T1992 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P49792 | RANBP2 | T2610 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P51114 | FXR1 | T483 | ochoa | RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628). Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (PubMed:25225333). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (PubMed:25225333). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (PubMed:39106863). {ECO:0000250|UniProtKB:Q61584, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:30067974, ECO:0000269|PubMed:30770808, ECO:0000269|PubMed:32706158, ECO:0000269|PubMed:34731628, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36306353, ECO:0000269|PubMed:39106863}. |
Q12802 | AKAP13 | T655 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
Q17R91 | DIAPH2 | T882 | psp | Protein diaphanous homolog 2 (Diaphanous-related formin-2) | None |
Q4G163 | FBXO43 | T234 | psp | F-box only protein 43 (Endogenous meiotic inhibitor 2) | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q8CDI2, ECO:0000269|PubMed:34052850, ECO:0000269|PubMed:34595750}. |
Q4LE39 | ARID4B | T481 | ochoa | AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) | Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}. |
Q4V9L6 | TMEM119 | T180 | ochoa | Transmembrane protein 119 (Osteoblast induction factor) (OBIF) | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}. |
Q5SW79 | CEP170 | T484 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
Q5VV67 | PPRC1 | T169 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
Q641Q2 | WASHC2A | T531 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q641Q2 | WASHC2A | T533 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q6KC79 | NIPBL | T914 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
Q7Z333 | SETX | T952 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
Q7Z3J3 | RGPD4 | T1017 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q86XL3 | ANKLE2 | T629 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
Q8N5P1 | ZC3H8 | T20 | ochoa | Zinc finger CCCH domain-containing protein 8 | Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}. |
Q8NC24 | RELL2 | T48 | ochoa | RELT-like protein 2 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
Q8TAQ2 | SMARCC2 | T278 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Q92621 | NUP205 | T1944 | ochoa | Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). In association with TMEM209, may be involved in nuclear transport of various nuclear proteins in addition to MYC (PubMed:22719065). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22719065, ECO:0000269|PubMed:9348540}. |
Q92766 | RREB1 | T1199 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
Q92804 | TAF15 | T222 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
Q92995 | USP13 | T122 | ochoa | Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) | Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response (PubMed:21571647, PubMed:32772043, PubMed:33592542). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy (PubMed:32101753). Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB (PubMed:32772043). In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1 (PubMed:33592542). Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion (PubMed:36585612). Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1 (PubMed:23940278, PubMed:28534493). {ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647, ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243, ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28534493, ECO:0000269|PubMed:32101753, ECO:0000269|PubMed:32772043, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:36585612}. |
Q99666 | RGPD5 | T1016 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
Q9BVI0 | PHF20 | T336 | ochoa | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}. |
Q9BZQ8 | NIBAN1 | T717 | ochoa | Protein Niban 1 (Cell growth-inhibiting gene 39 protein) (Protein FAM129A) | Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). {ECO:0000250}. |
Q9H2M9 | RAB3GAP2 | T1242 | ochoa | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}. |
Q9P270 | SLAIN2 | T313 | ochoa | SLAIN motif-containing protein 2 | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}. |
Q9UJX6 | ANAPC2 | T466 | ochoa | Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) | Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11739784, PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BZQ7, ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}. |
Q9Y4F1 | FARP1 | T883 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
Q9Y6J8 | STYXL1 | T83 | ochoa | Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Inactive dual specificity protein phosphatase MK-STYX) (Map kinase phosphatase-like protein MK-STYX) | Catalytically inactive phosphatase (PubMed:20180778, PubMed:23163895). By binding to G3BP1, inhibits the formation of G3BP1-induced stress granules (PubMed:20180778, PubMed:23163895). Does not act by protecting the dephosphorylation of G3BP1 at 'Ser-149' (PubMed:23163895). Inhibits PTPMT1 phosphatase activity (PubMed:24709986). By inhibiting PTPMT1, positively regulates intrinsic apoptosis (PubMed:21262771). May play a role in the formation of neurites during neuronal development (PubMed:29250526). {ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:21262771, ECO:0000269|PubMed:23163895, ECO:0000269|PubMed:24709986, ECO:0000269|PubMed:29250526}. |
Q15648 | MED1 | T704 | EPSD|PSP | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
O76021 | RSL1D1 | T312 | Sugiyama | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
P22314 | UBA1 | Y845 | Sugiyama | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
P30419 | NMT1 | T134 | Sugiyama | Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-) | Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017). {ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:32111831, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 0.000222 | 3.654 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.000424 | 3.373 |
R-HSA-71384 | Ethanol oxidation | 0.000222 | 3.654 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 0.000523 | 3.281 |
R-HSA-162906 | HIV Infection | 0.000539 | 3.269 |
R-HSA-5365859 | RA biosynthesis pathway | 0.000670 | 3.174 |
R-HSA-162587 | HIV Life Cycle | 0.000781 | 3.107 |
R-HSA-69541 | Stabilization of p53 | 0.000932 | 3.030 |
R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.001184 | 2.927 |
R-HSA-8851680 | Butyrophilin (BTN) family interactions | 0.001154 | 2.938 |
R-HSA-68886 | M Phase | 0.001316 | 2.881 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.001718 | 2.765 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.001718 | 2.765 |
R-HSA-68882 | Mitotic Anaphase | 0.002880 | 2.541 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.002932 | 2.533 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 0.002489 | 2.604 |
R-HSA-1433559 | Regulation of KIT signaling | 0.002556 | 2.593 |
R-HSA-1640170 | Cell Cycle | 0.002853 | 2.545 |
R-HSA-5362517 | Signaling by Retinoic Acid | 0.002825 | 2.549 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.003188 | 2.496 |
R-HSA-3247509 | Chromatin modifying enzymes | 0.003931 | 2.405 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.004443 | 2.352 |
R-HSA-4839726 | Chromatin organization | 0.004998 | 2.301 |
R-HSA-71288 | Creatine metabolism | 0.004840 | 2.315 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 0.004863 | 2.313 |
R-HSA-69620 | Cell Cycle Checkpoints | 0.005729 | 2.242 |
R-HSA-9734767 | Developmental Cell Lineages | 0.006167 | 2.210 |
R-HSA-5633007 | Regulation of TP53 Activity | 0.006244 | 2.205 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.007124 | 2.147 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.009750 | 2.011 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.010272 | 1.988 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.010272 | 1.988 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.011353 | 1.945 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.011353 | 1.945 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.011912 | 1.924 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.013064 | 1.884 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.015508 | 1.809 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.016147 | 1.792 |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.016147 | 1.792 |
R-HSA-167161 | HIV Transcription Initiation | 0.017459 | 1.758 |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.017459 | 1.758 |
R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.018815 | 1.726 |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.017459 | 1.758 |
R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.012482 | 1.904 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.014263 | 1.846 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.013360 | 1.874 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.011912 | 1.924 |
R-HSA-180746 | Nuclear import of Rev protein | 0.012482 | 1.904 |
R-HSA-75108 | Activation, myristolyation of BID and translocation to mitochondria | 0.016263 | 1.789 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.016147 | 1.792 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.016147 | 1.792 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.016797 | 1.775 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.014880 | 1.827 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.015508 | 1.809 |
R-HSA-69278 | Cell Cycle, Mitotic | 0.010167 | 1.993 |
R-HSA-68875 | Mitotic Prophase | 0.017868 | 1.748 |
R-HSA-1433557 | Signaling by SCF-KIT | 0.018815 | 1.726 |
R-HSA-6804757 | Regulation of TP53 Degradation | 0.013658 | 1.865 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.015508 | 1.809 |
R-HSA-162909 | Host Interactions of HIV factors | 0.019294 | 1.715 |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.020214 | 1.694 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.020214 | 1.694 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.020214 | 1.694 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.020214 | 1.694 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.020929 | 1.679 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.021655 | 1.664 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.020929 | 1.679 |
R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 0.020929 | 1.679 |
R-HSA-2514856 | The phototransduction cascade | 0.024661 | 1.608 |
R-HSA-9018519 | Estrogen-dependent gene expression | 0.025187 | 1.599 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.025437 | 1.595 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.026224 | 1.581 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.026224 | 1.581 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 0.026224 | 1.581 |
R-HSA-445355 | Smooth Muscle Contraction | 0.026224 | 1.581 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.027827 | 1.556 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.028643 | 1.543 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.027021 | 1.568 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.031147 | 1.507 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.033735 | 1.472 |
R-HSA-194441 | Metabolism of non-coding RNA | 0.031147 | 1.507 |
R-HSA-191859 | snRNP Assembly | 0.031147 | 1.507 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 0.032863 | 1.483 |
R-HSA-6784531 | tRNA processing in the nucleus | 0.033735 | 1.472 |
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.033893 | 1.470 |
R-HSA-114516 | Disinhibition of SNARE formation | 0.040170 | 1.396 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.041977 | 1.377 |
R-HSA-453276 | Regulation of mitotic cell cycle | 0.041977 | 1.377 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.043901 | 1.358 |
R-HSA-2467813 | Separation of Sister Chromatids | 0.039026 | 1.409 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 0.040170 | 1.396 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.040085 | 1.397 |
R-HSA-9010642 | ROBO receptors bind AKAP5 | 0.044098 | 1.356 |
R-HSA-69052 | Switching of origins to a post-replicative state | 0.043901 | 1.358 |
R-HSA-5693606 | DNA Double Strand Break Response | 0.038227 | 1.418 |
R-HSA-167172 | Transcription of the HIV genome | 0.039152 | 1.407 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.042935 | 1.367 |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.044876 | 1.348 |
R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.048011 | 1.319 |
R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.040170 | 1.396 |
R-HSA-430116 | GP1b-IX-V activation signalling | 0.048011 | 1.319 |
R-HSA-4086400 | PCP/CE pathway | 0.048853 | 1.311 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.042935 | 1.367 |
R-HSA-1169408 | ISG15 antiviral mechanism | 0.045858 | 1.339 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.050888 | 1.293 |
R-HSA-380612 | Metabolism of serotonin | 0.051908 | 1.285 |
R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.051908 | 1.285 |
R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.051917 | 1.285 |
R-HSA-212165 | Epigenetic regulation of gene expression | 0.052431 | 1.280 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.052954 | 1.276 |
R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.067339 | 1.172 |
R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.071158 | 1.148 |
R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.074961 | 1.125 |
R-HSA-176412 | Phosphorylation of the APC/C | 0.078749 | 1.104 |
R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.078749 | 1.104 |
R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 0.082522 | 1.083 |
R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.093750 | 1.028 |
R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.097462 | 1.011 |
R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 0.101160 | 0.995 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.127188 | 0.896 |
R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.119424 | 0.923 |
R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.119424 | 0.923 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 0.076315 | 1.117 |
R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 0.086280 | 1.064 |
R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 0.090023 | 1.046 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.104842 | 0.979 |
R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 0.082522 | 1.083 |
R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.126627 | 0.897 |
R-HSA-399719 | Trafficking of AMPA receptors | 0.140860 | 0.851 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.140860 | 0.851 |
R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.156973 | 0.804 |
R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 0.082522 | 1.083 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.090023 | 1.046 |
R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.119424 | 0.923 |
R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.137323 | 0.862 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.144382 | 0.840 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.158330 | 0.800 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.158330 | 0.800 |
R-HSA-399997 | Acetylcholine regulates insulin secretion | 0.082522 | 1.083 |
R-HSA-4641258 | Degradation of DVL | 0.165219 | 0.782 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.124830 | 0.904 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 0.059654 | 1.224 |
R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.063504 | 1.197 |
R-HSA-432047 | Passive transport by Aquaporins | 0.082522 | 1.083 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.161781 | 0.791 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.161781 | 0.791 |
R-HSA-4641257 | Degradation of AXIN | 0.165219 | 0.782 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.165219 | 0.782 |
R-HSA-69481 | G2/M Checkpoints | 0.115405 | 0.938 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.093750 | 1.028 |
R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 0.147890 | 0.830 |
R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.067339 | 1.172 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.067339 | 1.172 |
R-HSA-391160 | Signal regulatory protein family interactions | 0.071158 | 1.148 |
R-HSA-70350 | Fructose catabolism | 0.078749 | 1.104 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.078749 | 1.104 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.123033 | 0.910 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 0.144382 | 0.840 |
R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.147890 | 0.830 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 0.151384 | 0.820 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.154864 | 0.810 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.154864 | 0.810 |
R-HSA-169911 | Regulation of Apoptosis | 0.158330 | 0.800 |
R-HSA-9837999 | Mitochondrial protein degradation | 0.068207 | 1.166 |
R-HSA-1592230 | Mitochondrial biogenesis | 0.101001 | 0.996 |
R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 0.063504 | 1.197 |
R-HSA-9706369 | Negative regulation of FLT3 | 0.078749 | 1.104 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.137323 | 0.862 |
R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 0.093750 | 1.028 |
R-HSA-5652084 | Fructose metabolism | 0.108510 | 0.965 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.158406 | 0.800 |
R-HSA-3214847 | HATs acetylate histones | 0.075139 | 1.124 |
R-HSA-1483249 | Inositol phosphate metabolism | 0.092124 | 1.036 |
R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 0.093750 | 1.028 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 0.155544 | 0.808 |
R-HSA-3214842 | HDMs demethylate histones | 0.119424 | 0.923 |
R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.137323 | 0.862 |
R-HSA-69239 | Synthesis of DNA | 0.085935 | 1.066 |
R-HSA-9610379 | HCMV Late Events | 0.161278 | 0.792 |
R-HSA-446353 | Cell-extracellular matrix interactions | 0.074961 | 1.125 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.154116 | 0.812 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.154864 | 0.810 |
R-HSA-69242 | S Phase | 0.148434 | 0.828 |
R-HSA-111933 | Calmodulin induced events | 0.161781 | 0.791 |
R-HSA-68867 | Assembly of the pre-replicative complex | 0.067074 | 1.173 |
R-HSA-70171 | Glycolysis | 0.076315 | 1.117 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.090023 | 1.046 |
R-HSA-111997 | CaM pathway | 0.161781 | 0.791 |
R-HSA-9909396 | Circadian clock | 0.123472 | 0.908 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.078686 | 1.104 |
R-HSA-69306 | DNA Replication | 0.155544 | 0.808 |
R-HSA-8983711 | OAS antiviral response | 0.063504 | 1.197 |
R-HSA-3000170 | Syndecan interactions | 0.112163 | 0.950 |
R-HSA-74160 | Gene expression (Transcription) | 0.109024 | 0.962 |
R-HSA-112311 | Neurotransmitter clearance | 0.137323 | 0.862 |
R-HSA-69002 | DNA Replication Pre-Initiation | 0.088395 | 1.054 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.130297 | 0.885 |
R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.154864 | 0.810 |
R-HSA-203615 | eNOS activation | 0.154864 | 0.810 |
R-HSA-70326 | Glucose metabolism | 0.101001 | 0.996 |
R-HSA-9824446 | Viral Infection Pathways | 0.096604 | 1.015 |
R-HSA-8939211 | ESR-mediated signaling | 0.088886 | 1.051 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.139998 | 0.854 |
R-HSA-8853659 | RET signaling | 0.161781 | 0.791 |
R-HSA-6807070 | PTEN Regulation | 0.134435 | 0.871 |
R-HSA-3371556 | Cellular response to heat stress | 0.106178 | 0.974 |
R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.158330 | 0.800 |
R-HSA-211945 | Phase I - Functionalization of compounds | 0.123569 | 0.908 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.138612 | 0.858 |
R-HSA-211000 | Gene Silencing by RNA | 0.085935 | 1.066 |
R-HSA-162582 | Signal Transduction | 0.062556 | 1.204 |
R-HSA-2187338 | Visual phototransduction | 0.147021 | 0.833 |
R-HSA-5619115 | Disorders of transmembrane transporters | 0.096915 | 1.014 |
R-HSA-1500931 | Cell-Cell communication | 0.159413 | 0.797 |
R-HSA-109581 | Apoptosis | 0.168501 | 0.773 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.168643 | 0.773 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.172053 | 0.764 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.172053 | 0.764 |
R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.172053 | 0.764 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.175449 | 0.756 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.175449 | 0.756 |
R-HSA-5619102 | SLC transporter disorders | 0.175780 | 0.755 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.178832 | 0.748 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.178832 | 0.748 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.178832 | 0.748 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.178832 | 0.748 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.178832 | 0.748 |
R-HSA-9607240 | FLT3 Signaling | 0.178832 | 0.748 |
R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.178832 | 0.748 |
R-HSA-72306 | tRNA processing | 0.181640 | 0.741 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 0.182201 | 0.739 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.182201 | 0.739 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.182201 | 0.739 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.182201 | 0.739 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.185556 | 0.732 |
R-HSA-73928 | Depyrimidination | 0.185556 | 0.732 |
R-HSA-111996 | Ca-dependent events | 0.185556 | 0.732 |
R-HSA-9006925 | Intracellular signaling by second messengers | 0.185585 | 0.731 |
R-HSA-5689880 | Ub-specific processing proteases | 0.186054 | 0.730 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.188898 | 0.724 |
R-HSA-9907900 | Proteasome assembly | 0.192226 | 0.716 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.192226 | 0.716 |
R-HSA-3214858 | RMTs methylate histone arginines | 0.192226 | 0.716 |
R-HSA-168255 | Influenza Infection | 0.194930 | 0.710 |
R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.195541 | 0.709 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.195541 | 0.709 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 0.195541 | 0.709 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.195541 | 0.709 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.195541 | 0.709 |
R-HSA-1489509 | DAG and IP3 signaling | 0.195541 | 0.709 |
R-HSA-9824272 | Somitogenesis | 0.195541 | 0.709 |
R-HSA-73894 | DNA Repair | 0.204339 | 0.690 |
R-HSA-9766229 | Degradation of CDH1 | 0.208666 | 0.681 |
R-HSA-5658442 | Regulation of RAS by GAPs | 0.211915 | 0.674 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.215150 | 0.667 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.215150 | 0.667 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 0.215150 | 0.667 |
R-HSA-68949 | Orc1 removal from chromatin | 0.218372 | 0.661 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.218372 | 0.661 |
R-HSA-9609690 | HCMV Early Events | 0.220348 | 0.657 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.224777 | 0.648 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.227960 | 0.642 |
R-HSA-3214815 | HDACs deacetylate histones | 0.227960 | 0.642 |
R-HSA-418597 | G alpha (z) signalling events | 0.227960 | 0.642 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.229999 | 0.638 |
R-HSA-913531 | Interferon Signaling | 0.229999 | 0.638 |
R-HSA-376176 | Signaling by ROBO receptors | 0.230903 | 0.637 |
R-HSA-193648 | NRAGE signals death through JNK | 0.231130 | 0.636 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.231130 | 0.636 |
R-HSA-9764561 | Regulation of CDH1 Function | 0.234288 | 0.630 |
R-HSA-5357801 | Programmed Cell Death | 0.235438 | 0.628 |
R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.243684 | 0.613 |
R-HSA-351202 | Metabolism of polyamines | 0.243684 | 0.613 |
R-HSA-1227986 | Signaling by ERBB2 | 0.243684 | 0.613 |
R-HSA-397014 | Muscle contraction | 0.246040 | 0.609 |
R-HSA-445717 | Aquaporin-mediated transport | 0.246791 | 0.608 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.246791 | 0.608 |
R-HSA-112043 | PLC beta mediated events | 0.246791 | 0.608 |
R-HSA-9793380 | Formation of paraxial mesoderm | 0.246791 | 0.608 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.249885 | 0.602 |
R-HSA-9707616 | Heme signaling | 0.249885 | 0.602 |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.252966 | 0.597 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.259092 | 0.587 |
R-HSA-1234174 | Cellular response to hypoxia | 0.259092 | 0.587 |
R-HSA-8951664 | Neddylation | 0.259700 | 0.586 |
R-HSA-112040 | G-protein mediated events | 0.265169 | 0.576 |
R-HSA-73857 | RNA Polymerase II Transcription | 0.267213 | 0.573 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.267296 | 0.573 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 0.270335 | 0.568 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.274191 | 0.562 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.274191 | 0.562 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.274191 | 0.562 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.277175 | 0.557 |
R-HSA-5632684 | Hedgehog 'on' state | 0.277175 | 0.557 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.280146 | 0.553 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.283105 | 0.548 |
R-HSA-4086398 | Ca2+ pathway | 0.283105 | 0.548 |
R-HSA-1266738 | Developmental Biology | 0.283561 | 0.547 |
R-HSA-69473 | G2/M DNA damage checkpoint | 0.286052 | 0.544 |
R-HSA-9013694 | Signaling by NOTCH4 | 0.286052 | 0.544 |
R-HSA-8852135 | Protein ubiquitination | 0.288987 | 0.539 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.288987 | 0.539 |
R-HSA-5689603 | UCH proteinases | 0.291910 | 0.535 |
R-HSA-383280 | Nuclear Receptor transcription pathway | 0.297722 | 0.526 |
R-HSA-416482 | G alpha (12/13) signalling events | 0.297722 | 0.526 |
R-HSA-5619084 | ABC transporter disorders | 0.297722 | 0.526 |
R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.300610 | 0.522 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.303486 | 0.518 |
R-HSA-9609646 | HCMV Infection | 0.303720 | 0.518 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.309204 | 0.510 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.309826 | 0.509 |
R-HSA-5688426 | Deubiquitination | 0.311281 | 0.507 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.312045 | 0.506 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 0.312045 | 0.506 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.314875 | 0.502 |
R-HSA-212436 | Generic Transcription Pathway | 0.315143 | 0.501 |
R-HSA-6802957 | Oncogenic MAPK signaling | 0.317693 | 0.498 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.317693 | 0.498 |
R-HSA-141424 | Amplification of signal from the kinetochores | 0.320500 | 0.494 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.320500 | 0.494 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.320500 | 0.494 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.320500 | 0.494 |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.323296 | 0.490 |
R-HSA-9711123 | Cellular response to chemical stress | 0.330862 | 0.480 |
R-HSA-1236974 | ER-Phagosome pathway | 0.331615 | 0.479 |
R-HSA-73884 | Base Excision Repair | 0.334366 | 0.476 |
R-HSA-202424 | Downstream TCR signaling | 0.334366 | 0.476 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 0.339853 | 0.469 |
R-HSA-446728 | Cell junction organization | 0.345828 | 0.461 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.347319 | 0.459 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.353311 | 0.452 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.355973 | 0.449 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.355973 | 0.449 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.358625 | 0.445 |
R-HSA-422356 | Regulation of insulin secretion | 0.361266 | 0.442 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.363897 | 0.439 |
R-HSA-5610787 | Hedgehog 'off' state | 0.366517 | 0.436 |
R-HSA-382556 | ABC-family proteins mediated transport | 0.366517 | 0.436 |
R-HSA-9020702 | Interleukin-1 signaling | 0.369126 | 0.433 |
R-HSA-1257604 | PIP3 activates AKT signaling | 0.371024 | 0.431 |
R-HSA-9842860 | Regulation of endogenous retroelements | 0.371724 | 0.430 |
R-HSA-195721 | Signaling by WNT | 0.375433 | 0.425 |
R-HSA-111885 | Opioid Signalling | 0.376890 | 0.424 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.377321 | 0.423 |
R-HSA-9833110 | RSV-host interactions | 0.379457 | 0.421 |
R-HSA-211859 | Biological oxidations | 0.386265 | 0.413 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.387096 | 0.412 |
R-HSA-9700206 | Signaling by ALK in cancer | 0.387096 | 0.412 |
R-HSA-1236975 | Antigen processing-Cross presentation | 0.389621 | 0.409 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.392137 | 0.407 |
R-HSA-202403 | TCR signaling | 0.394642 | 0.404 |
R-HSA-5663205 | Infectious disease | 0.403782 | 0.394 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 0.407380 | 0.390 |
R-HSA-112315 | Transmission across Chemical Synapses | 0.411679 | 0.385 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.411895 | 0.385 |
R-HSA-9007101 | Rab regulation of trafficking | 0.416735 | 0.380 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.421536 | 0.375 |
R-HSA-9679506 | SARS-CoV Infections | 0.421735 | 0.375 |
R-HSA-2262752 | Cellular responses to stress | 0.423152 | 0.374 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.426298 | 0.370 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.426298 | 0.370 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.431021 | 0.366 |
R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.438035 | 0.358 |
R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.438035 | 0.358 |
R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.438035 | 0.358 |
R-HSA-194138 | Signaling by VEGF | 0.438035 | 0.358 |
R-HSA-69206 | G1/S Transition | 0.438035 | 0.358 |
R-HSA-114608 | Platelet degranulation | 0.442663 | 0.354 |
R-HSA-1280218 | Adaptive Immune System | 0.446106 | 0.351 |
R-HSA-9694516 | SARS-CoV-2 Infection | 0.448290 | 0.348 |
R-HSA-9843745 | Adipogenesis | 0.454069 | 0.343 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.456323 | 0.341 |
R-HSA-163685 | Integration of energy metabolism | 0.467454 | 0.330 |
R-HSA-8953854 | Metabolism of RNA | 0.468165 | 0.330 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 0.468863 | 0.329 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.469653 | 0.328 |
R-HSA-9948299 | Ribosome-associated quality control | 0.471843 | 0.326 |
R-HSA-5358351 | Signaling by Hedgehog | 0.471843 | 0.326 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 0.486927 | 0.313 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 0.489464 | 0.310 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.491159 | 0.309 |
R-HSA-9758941 | Gastrulation | 0.497441 | 0.303 |
R-HSA-9856651 | MITF-M-dependent gene expression | 0.499518 | 0.301 |
R-HSA-9679191 | Potential therapeutics for SARS | 0.499518 | 0.301 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.501587 | 0.300 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.503647 | 0.298 |
R-HSA-446652 | Interleukin-1 family signaling | 0.503647 | 0.298 |
R-HSA-73887 | Death Receptor Signaling | 0.507743 | 0.294 |
R-HSA-1989781 | PPARA activates gene expression | 0.509778 | 0.293 |
R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.513823 | 0.289 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.515834 | 0.287 |
R-HSA-8953897 | Cellular responses to stimuli | 0.525268 | 0.280 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.543135 | 0.265 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.545026 | 0.264 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.546909 | 0.262 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.546909 | 0.262 |
R-HSA-2559583 | Cellular Senescence | 0.559879 | 0.252 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 0.565325 | 0.248 |
R-HSA-69275 | G2/M Transition | 0.570705 | 0.244 |
R-HSA-453274 | Mitotic G2-G2/M phases | 0.574255 | 0.241 |
R-HSA-68877 | Mitotic Prometaphase | 0.583003 | 0.234 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.588167 | 0.230 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.594955 | 0.226 |
R-HSA-389948 | Co-inhibition by PD-1 | 0.594955 | 0.226 |
R-HSA-112316 | Neuronal System | 0.599318 | 0.222 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.599973 | 0.222 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.616262 | 0.210 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.617854 | 0.209 |
R-HSA-418990 | Adherens junctions interactions | 0.625720 | 0.204 |
R-HSA-157118 | Signaling by NOTCH | 0.658476 | 0.181 |
R-HSA-421270 | Cell-cell junction organization | 0.673778 | 0.171 |
R-HSA-422475 | Axon guidance | 0.679066 | 0.168 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.680508 | 0.167 |
R-HSA-416476 | G alpha (q) signalling events | 0.690994 | 0.161 |
R-HSA-597592 | Post-translational protein modification | 0.698200 | 0.156 |
R-HSA-9675108 | Nervous system development | 0.712643 | 0.147 |
R-HSA-5673001 | RAF/MAP kinase cascade | 0.721624 | 0.142 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.729650 | 0.137 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.738513 | 0.132 |
R-HSA-1643685 | Disease | 0.755001 | 0.122 |
R-HSA-8957322 | Metabolism of steroids | 0.759540 | 0.119 |
R-HSA-1474244 | Extracellular matrix organization | 0.766489 | 0.115 |
R-HSA-5683057 | MAPK family signaling cascades | 0.781637 | 0.107 |
R-HSA-392499 | Metabolism of proteins | 0.798038 | 0.098 |
R-HSA-168256 | Immune System | 0.830587 | 0.081 |
R-HSA-418594 | G alpha (i) signalling events | 0.831014 | 0.080 |
R-HSA-388396 | GPCR downstream signalling | 0.843347 | 0.074 |
R-HSA-72766 | Translation | 0.845975 | 0.073 |
R-HSA-109582 | Hemostasis | 0.848421 | 0.071 |
R-HSA-6798695 | Neutrophil degranulation | 0.863141 | 0.064 |
R-HSA-372790 | Signaling by GPCR | 0.881224 | 0.055 |
R-HSA-382551 | Transport of small molecules | 0.922508 | 0.035 |
R-HSA-1430728 | Metabolism | 0.928834 | 0.032 |
R-HSA-449147 | Signaling by Interleukins | 0.932947 | 0.030 |
R-HSA-199991 | Membrane Trafficking | 0.939224 | 0.027 |
R-HSA-9709957 | Sensory Perception | 0.969272 | 0.014 |
R-HSA-5653656 | Vesicle-mediated transport | 0.969448 | 0.013 |
R-HSA-168249 | Innate Immune System | 0.996908 | 0.001 |
R-HSA-556833 | Metabolism of lipids | 0.998488 | 0.001 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
GAK |
0.765 | 0.017 | 1 | 0.647 |
GCK |
0.759 | 0.083 | 1 | 0.678 |
DAPK2 |
0.759 | 0.170 | -3 | 0.667 |
DAPK3 |
0.758 | 0.175 | -3 | 0.674 |
TAK1 |
0.758 | -0.043 | 1 | 0.682 |
KHS1 |
0.756 | 0.081 | 1 | 0.654 |
KHS2 |
0.755 | 0.092 | 1 | 0.674 |
HPK1 |
0.754 | 0.084 | 1 | 0.678 |
BRAF |
0.754 | 0.023 | -4 | 0.794 |
DMPK1 |
0.754 | 0.160 | -3 | 0.694 |
TNIK |
0.753 | 0.005 | 3 | 0.552 |
NIK |
0.751 | 0.125 | -3 | 0.683 |
MINK |
0.751 | -0.035 | 1 | 0.656 |
PKR |
0.750 | -0.044 | 1 | 0.646 |
CAMLCK |
0.750 | 0.102 | -2 | 0.853 |
MEK1 |
0.750 | -0.038 | 2 | 0.644 |
SMMLCK |
0.749 | 0.102 | -3 | 0.650 |
LKB1 |
0.748 | -0.031 | -3 | 0.573 |
NEK1 |
0.748 | -0.088 | 1 | 0.620 |
TAO2 |
0.748 | 0.005 | 2 | 0.653 |
CAMK1B |
0.747 | 0.156 | -3 | 0.687 |
VRK2 |
0.747 | -0.233 | 1 | 0.673 |
DAPK1 |
0.747 | 0.149 | -3 | 0.648 |
LRRK2 |
0.746 | -0.093 | 2 | 0.640 |
ASK1 |
0.746 | -0.111 | 1 | 0.607 |
SKMLCK |
0.746 | 0.228 | -2 | 0.869 |
LATS1 |
0.745 | 0.122 | -3 | 0.637 |
HGK |
0.745 | -0.052 | 3 | 0.547 |
MST3 |
0.745 | 0.035 | 2 | 0.670 |
TAO3 |
0.744 | 0.059 | 1 | 0.650 |
ALK4 |
0.744 | 0.006 | -2 | 0.762 |
MST1 |
0.744 | -0.070 | 1 | 0.649 |
ROCK2 |
0.744 | 0.128 | -3 | 0.661 |
PDK1 |
0.743 | -0.053 | 1 | 0.651 |
PASK |
0.743 | 0.078 | -3 | 0.617 |
MST2 |
0.743 | -0.084 | 1 | 0.663 |
BMPR2 |
0.743 | -0.137 | -2 | 0.809 |
BMPR1B |
0.742 | 0.128 | 1 | 0.715 |
VRK1 |
0.742 | -0.193 | 2 | 0.625 |
NEK5 |
0.742 | -0.097 | 1 | 0.640 |
TTK |
0.742 | -0.085 | -2 | 0.755 |
ALK2 |
0.742 | 0.046 | -2 | 0.737 |
MEKK6 |
0.741 | -0.084 | 1 | 0.632 |
MAP3K15 |
0.741 | -0.092 | 1 | 0.614 |
MOS |
0.741 | 0.075 | 1 | 0.732 |
TGFBR1 |
0.740 | 0.058 | -2 | 0.731 |
NEK4 |
0.739 | -0.090 | 1 | 0.627 |
JNK2 |
0.739 | 0.052 | 1 | 0.509 |
CAMKK2 |
0.739 | -0.092 | -2 | 0.706 |
EEF2K |
0.739 | -0.096 | 3 | 0.527 |
MEK2 |
0.738 | -0.145 | 2 | 0.598 |
NEK11 |
0.738 | -0.081 | 1 | 0.657 |
PBK |
0.737 | -0.030 | 1 | 0.562 |
MEK5 |
0.737 | -0.186 | 2 | 0.622 |
PRPK |
0.737 | -0.058 | -1 | 0.838 |
MEKK2 |
0.736 | -0.143 | 2 | 0.597 |
YSK1 |
0.736 | -0.064 | 2 | 0.622 |
MYO3B |
0.736 | -0.092 | 2 | 0.630 |
CAMKK1 |
0.736 | -0.139 | -2 | 0.712 |
MYO3A |
0.736 | -0.084 | 1 | 0.612 |
BIKE |
0.736 | -0.066 | 1 | 0.514 |
ANKRD3 |
0.735 | -0.099 | 1 | 0.680 |
DLK |
0.735 | -0.069 | 1 | 0.681 |
LOK |
0.735 | 0.017 | -2 | 0.732 |
ALPHAK3 |
0.734 | -0.075 | -1 | 0.729 |
NEK8 |
0.734 | -0.130 | 2 | 0.609 |
BMPR1A |
0.733 | 0.101 | 1 | 0.691 |
YSK4 |
0.733 | -0.064 | 1 | 0.642 |
RAF1 |
0.733 | 0.079 | 1 | 0.700 |
ATR |
0.733 | -0.005 | 1 | 0.672 |
JNK3 |
0.733 | 0.025 | 1 | 0.535 |
CDKL1 |
0.732 | -0.005 | -3 | 0.595 |
ROCK1 |
0.732 | 0.110 | -3 | 0.657 |
PIM1 |
0.732 | 0.129 | -3 | 0.636 |
MRCKA |
0.731 | 0.127 | -3 | 0.660 |
ICK |
0.731 | 0.011 | -3 | 0.618 |
CHK1 |
0.731 | 0.160 | -3 | 0.670 |
TSSK2 |
0.731 | 0.141 | -5 | 0.774 |
ACVR2B |
0.731 | 0.023 | -2 | 0.737 |
MEKK3 |
0.730 | -0.109 | 1 | 0.646 |
AMPKA1 |
0.729 | 0.180 | -3 | 0.695 |
DCAMKL1 |
0.729 | 0.153 | -3 | 0.697 |
NLK |
0.729 | -0.032 | 1 | 0.670 |
CAMK2G |
0.729 | 0.045 | 2 | 0.697 |
MPSK1 |
0.728 | -0.083 | 1 | 0.565 |
P38A |
0.728 | 0.002 | 1 | 0.567 |
TSSK1 |
0.728 | 0.206 | -3 | 0.707 |
MYLK4 |
0.728 | 0.146 | -2 | 0.825 |
MEKK1 |
0.728 | -0.188 | 1 | 0.625 |
GRK6 |
0.728 | 0.097 | 1 | 0.705 |
STLK3 |
0.727 | -0.174 | 1 | 0.598 |
CDC7 |
0.727 | 0.170 | 1 | 0.743 |
DNAPK |
0.727 | 0.056 | 1 | 0.597 |
ACVR2A |
0.727 | 0.009 | -2 | 0.715 |
CLK3 |
0.727 | 0.160 | 1 | 0.680 |
MRCKB |
0.726 | 0.111 | -3 | 0.655 |
NUAK2 |
0.726 | 0.171 | -3 | 0.700 |
ZAK |
0.726 | -0.150 | 1 | 0.625 |
OSR1 |
0.726 | -0.147 | 2 | 0.602 |
CRIK |
0.725 | 0.071 | -3 | 0.589 |
PIM2 |
0.725 | 0.081 | -3 | 0.634 |
PDHK4 |
0.725 | -0.018 | 1 | 0.704 |
P38B |
0.725 | 0.006 | 1 | 0.526 |
CAMK1D |
0.725 | 0.145 | -3 | 0.642 |
AAK1 |
0.725 | -0.049 | 1 | 0.423 |
CAMK2D |
0.725 | 0.133 | -3 | 0.652 |
MST4 |
0.725 | 0.135 | 2 | 0.738 |
PKN3 |
0.724 | 0.050 | -3 | 0.631 |
WNK1 |
0.724 | 0.115 | -2 | 0.847 |
P70S6KB |
0.724 | 0.105 | -3 | 0.662 |
PIM3 |
0.724 | 0.118 | -3 | 0.634 |
AKT2 |
0.724 | 0.107 | -3 | 0.604 |
CLK4 |
0.723 | 0.126 | -3 | 0.653 |
TAO1 |
0.723 | -0.038 | 1 | 0.579 |
MLK2 |
0.723 | -0.122 | 2 | 0.622 |
PDHK1 |
0.723 | 0.033 | 1 | 0.689 |
DCAMKL2 |
0.723 | 0.113 | -3 | 0.731 |
CAMK2B |
0.723 | 0.185 | 2 | 0.719 |
SLK |
0.722 | 0.005 | -2 | 0.657 |
AMPKA2 |
0.722 | 0.179 | -3 | 0.690 |
PLK1 |
0.722 | -0.015 | -2 | 0.747 |
ERK5 |
0.722 | -0.000 | 1 | 0.668 |
DRAK1 |
0.721 | 0.056 | 1 | 0.703 |
CAMK2A |
0.721 | 0.188 | 2 | 0.719 |
WNK4 |
0.720 | -0.031 | -2 | 0.829 |
MARK4 |
0.720 | 0.131 | 4 | 0.750 |
HIPK1 |
0.720 | 0.037 | 1 | 0.544 |
PRP4 |
0.719 | -0.074 | -3 | 0.479 |
HUNK |
0.719 | 0.088 | 2 | 0.600 |
SGK3 |
0.719 | 0.105 | -3 | 0.625 |
NEK2 |
0.719 | -0.065 | 2 | 0.598 |
PKN2 |
0.718 | 0.091 | -3 | 0.675 |
PKCD |
0.718 | 0.064 | 2 | 0.599 |
GRK5 |
0.717 | -0.026 | -3 | 0.581 |
GRK7 |
0.717 | 0.049 | 1 | 0.642 |
SGK1 |
0.717 | 0.080 | -3 | 0.519 |
MASTL |
0.717 | -0.154 | -2 | 0.765 |
RIPK3 |
0.717 | -0.015 | 3 | 0.533 |
NEK9 |
0.717 | -0.134 | 2 | 0.635 |
CHK2 |
0.716 | 0.071 | -3 | 0.589 |
MARK1 |
0.716 | 0.199 | 4 | 0.717 |
RSK2 |
0.716 | 0.127 | -3 | 0.631 |
PERK |
0.716 | -0.181 | -2 | 0.766 |
DSTYK |
0.716 | -0.047 | 2 | 0.736 |
COT |
0.716 | 0.015 | 2 | 0.710 |
CAMK4 |
0.716 | 0.141 | -3 | 0.699 |
MELK |
0.715 | 0.128 | -3 | 0.688 |
MSK1 |
0.715 | 0.123 | -3 | 0.573 |
HRI |
0.715 | -0.182 | -2 | 0.784 |
TLK2 |
0.715 | -0.077 | 1 | 0.618 |
RIPK1 |
0.715 | -0.103 | 1 | 0.627 |
ATM |
0.715 | 0.017 | 1 | 0.621 |
SBK |
0.715 | 0.083 | -3 | 0.532 |
PLK3 |
0.714 | -0.009 | 2 | 0.626 |
DYRK1A |
0.714 | 0.024 | 1 | 0.584 |
CLK1 |
0.714 | 0.133 | -3 | 0.672 |
MARK2 |
0.713 | 0.145 | 4 | 0.660 |
DYRK2 |
0.713 | 0.024 | 1 | 0.532 |
ERK2 |
0.713 | -0.031 | 1 | 0.550 |
TLK1 |
0.713 | -0.109 | -2 | 0.765 |
AKT1 |
0.712 | 0.110 | -3 | 0.622 |
MAK |
0.712 | 0.019 | -2 | 0.684 |
PAK1 |
0.712 | 0.116 | -2 | 0.823 |
PRKD3 |
0.712 | 0.101 | -3 | 0.643 |
IRAK4 |
0.711 | -0.109 | 1 | 0.601 |
MLK1 |
0.711 | -0.150 | 2 | 0.638 |
BUB1 |
0.711 | -0.020 | -5 | 0.723 |
NEK3 |
0.711 | -0.165 | 1 | 0.589 |
JNK1 |
0.710 | 0.002 | 1 | 0.504 |
PAK2 |
0.710 | 0.065 | -2 | 0.809 |
CDKL5 |
0.710 | -0.009 | -3 | 0.589 |
PRKD1 |
0.710 | 0.141 | -3 | 0.614 |
P90RSK |
0.710 | 0.070 | -3 | 0.606 |
QSK |
0.710 | 0.149 | 4 | 0.725 |
P38D |
0.710 | 0.004 | 1 | 0.448 |
AURB |
0.710 | 0.128 | -2 | 0.707 |
MTOR |
0.710 | -0.026 | 1 | 0.646 |
HIPK3 |
0.709 | 0.004 | 1 | 0.545 |
HASPIN |
0.709 | -0.029 | -1 | 0.646 |
GRK2 |
0.709 | 0.003 | -2 | 0.654 |
P38G |
0.709 | -0.003 | 1 | 0.443 |
SSTK |
0.709 | 0.127 | 4 | 0.755 |
WNK3 |
0.709 | -0.020 | 1 | 0.647 |
QIK |
0.708 | 0.102 | -3 | 0.674 |
MARK3 |
0.708 | 0.166 | 4 | 0.697 |
MAPKAPK3 |
0.708 | 0.110 | -3 | 0.631 |
CAMK1A |
0.708 | 0.103 | -3 | 0.600 |
MOK |
0.708 | 0.004 | 1 | 0.554 |
PRKD2 |
0.707 | 0.166 | -3 | 0.663 |
PAK3 |
0.707 | 0.095 | -2 | 0.826 |
SIK |
0.706 | 0.164 | -3 | 0.660 |
SMG1 |
0.706 | -0.031 | 1 | 0.625 |
CLK2 |
0.705 | 0.140 | -3 | 0.637 |
CAMK1G |
0.705 | 0.054 | -3 | 0.643 |
PKACB |
0.705 | 0.172 | -2 | 0.728 |
AURA |
0.705 | 0.125 | -2 | 0.683 |
CDK14 |
0.705 | 0.001 | 1 | 0.513 |
NUAK1 |
0.705 | 0.130 | -3 | 0.688 |
DYRK4 |
0.704 | 0.050 | 1 | 0.483 |
ERK1 |
0.704 | -0.019 | 1 | 0.512 |
ERK7 |
0.704 | -0.044 | 2 | 0.392 |
DYRK1B |
0.704 | 0.027 | 1 | 0.497 |
TGFBR2 |
0.704 | -0.059 | -2 | 0.729 |
DYRK3 |
0.703 | 0.034 | 1 | 0.534 |
TBK1 |
0.703 | -0.033 | 1 | 0.621 |
HIPK4 |
0.703 | 0.019 | 1 | 0.609 |
RSK4 |
0.703 | 0.108 | -3 | 0.603 |
GSK3B |
0.703 | -0.010 | 4 | 0.431 |
MLK3 |
0.703 | -0.086 | 2 | 0.573 |
PINK1 |
0.703 | -0.186 | 1 | 0.627 |
MSK2 |
0.703 | 0.064 | -3 | 0.554 |
NDR1 |
0.703 | 0.085 | -3 | 0.664 |
CDK5 |
0.703 | -0.025 | 1 | 0.547 |
BCKDK |
0.702 | 0.142 | -1 | 0.850 |
SRPK1 |
0.702 | 0.026 | -3 | 0.576 |
CHAK2 |
0.702 | -0.123 | -1 | 0.809 |
IRAK1 |
0.702 | -0.159 | -1 | 0.768 |
PKCH |
0.701 | 0.010 | 2 | 0.525 |
PLK2 |
0.701 | -0.015 | -3 | 0.532 |
PKCA |
0.701 | 0.009 | 2 | 0.543 |
MNK2 |
0.700 | 0.147 | -2 | 0.814 |
PKCB |
0.700 | 0.032 | 2 | 0.559 |
MAPKAPK2 |
0.700 | 0.143 | -3 | 0.598 |
PKACG |
0.700 | 0.110 | -2 | 0.765 |
RIPK2 |
0.700 | -0.153 | 1 | 0.593 |
PKCZ |
0.700 | -0.007 | 2 | 0.566 |
CDK1 |
0.700 | -0.013 | 1 | 0.520 |
LATS2 |
0.700 | 0.117 | -5 | 0.661 |
RSK3 |
0.700 | 0.075 | -3 | 0.613 |
NEK7 |
0.700 | -0.147 | -3 | 0.551 |
MLK4 |
0.699 | -0.146 | 2 | 0.541 |
NIM1 |
0.699 | -0.003 | 3 | 0.569 |
GSK3A |
0.699 | 0.003 | 4 | 0.439 |
PKG2 |
0.699 | 0.116 | -2 | 0.715 |
MNK1 |
0.699 | 0.146 | -2 | 0.824 |
CK2A2 |
0.698 | 0.131 | 1 | 0.703 |
AURC |
0.698 | 0.157 | -2 | 0.706 |
NDR2 |
0.698 | 0.145 | -3 | 0.650 |
SRPK3 |
0.698 | -0.020 | -3 | 0.543 |
HIPK2 |
0.698 | 0.047 | 1 | 0.462 |
PAK6 |
0.698 | 0.213 | -2 | 0.759 |
GRK1 |
0.697 | 0.046 | -2 | 0.734 |
IKKE |
0.696 | -0.052 | 1 | 0.626 |
ULK2 |
0.696 | -0.167 | 2 | 0.565 |
P70S6K |
0.696 | 0.039 | -3 | 0.584 |
NEK6 |
0.696 | -0.092 | -2 | 0.782 |
PKACA |
0.696 | 0.147 | -2 | 0.680 |
IKKB |
0.696 | 0.007 | -2 | 0.713 |
CDK16 |
0.695 | 0.004 | 1 | 0.455 |
CDK2 |
0.695 | -0.057 | 1 | 0.581 |
PKCE |
0.695 | 0.036 | 2 | 0.538 |
CHAK1 |
0.695 | -0.156 | 2 | 0.534 |
BRSK1 |
0.695 | 0.175 | -3 | 0.664 |
CDK4 |
0.695 | -0.029 | 1 | 0.487 |
CDK17 |
0.695 | -0.008 | 1 | 0.443 |
IKKA |
0.694 | 0.046 | -2 | 0.684 |
CDK7 |
0.694 | -0.004 | 1 | 0.542 |
AKT3 |
0.694 | 0.074 | -3 | 0.531 |
FAM20C |
0.693 | 0.147 | 2 | 0.642 |
PDHK3_TYR |
0.693 | 0.147 | 4 | 0.795 |
PKCG |
0.693 | 0.019 | 2 | 0.555 |
IRE2 |
0.693 | -0.125 | 2 | 0.533 |
PKCI |
0.693 | -0.002 | 2 | 0.545 |
GRK4 |
0.693 | -0.066 | -2 | 0.769 |
CDK18 |
0.692 | -0.001 | 1 | 0.481 |
PKCT |
0.692 | 0.003 | 2 | 0.531 |
CDK6 |
0.691 | -0.049 | 1 | 0.491 |
CK2A1 |
0.691 | 0.110 | 1 | 0.699 |
IRE1 |
0.691 | -0.126 | 1 | 0.586 |
PKN1 |
0.689 | 0.034 | -3 | 0.623 |
CDK3 |
0.689 | -0.014 | 1 | 0.461 |
CDK10 |
0.689 | 0.010 | 1 | 0.500 |
PRKX |
0.688 | 0.198 | -3 | 0.636 |
CDK9 |
0.688 | -0.030 | 1 | 0.523 |
CDK13 |
0.688 | -0.045 | 1 | 0.519 |
TTBK2 |
0.688 | -0.163 | 2 | 0.494 |
PHKG1 |
0.687 | 0.036 | -3 | 0.678 |
CDK8 |
0.687 | -0.030 | 1 | 0.525 |
PLK4 |
0.687 | -0.094 | 2 | 0.417 |
PDHK4_TYR |
0.686 | 0.088 | 2 | 0.726 |
BRSK2 |
0.686 | 0.095 | -3 | 0.694 |
SRPK2 |
0.686 | 0.022 | -3 | 0.531 |
CDK12 |
0.685 | -0.042 | 1 | 0.499 |
TESK1_TYR |
0.685 | 0.008 | 3 | 0.601 |
MAP2K6_TYR |
0.684 | 0.028 | -1 | 0.850 |
ULK1 |
0.684 | -0.160 | -3 | 0.540 |
DDR1 |
0.682 | 0.078 | 4 | 0.785 |
GRK3 |
0.682 | -0.006 | -2 | 0.615 |
MAP2K4_TYR |
0.682 | -0.025 | -1 | 0.847 |
SNRK |
0.681 | -0.035 | 2 | 0.459 |
PHKG2 |
0.680 | 0.111 | -3 | 0.736 |
CK1D |
0.679 | -0.056 | -3 | 0.304 |
PDHK1_TYR |
0.678 | -0.016 | -1 | 0.847 |
BMPR2_TYR |
0.678 | -0.014 | -1 | 0.802 |
GCN2 |
0.678 | -0.193 | 2 | 0.610 |
MAP2K7_TYR |
0.678 | -0.109 | 2 | 0.675 |
STK33 |
0.678 | -0.163 | 2 | 0.424 |
PAK5 |
0.677 | 0.135 | -2 | 0.693 |
EPHA6 |
0.677 | -0.014 | -1 | 0.812 |
LIMK2_TYR |
0.677 | 0.008 | -3 | 0.662 |
MAPKAPK5 |
0.675 | -0.052 | -3 | 0.529 |
RET |
0.675 | -0.067 | 1 | 0.638 |
PKMYT1_TYR |
0.675 | -0.140 | 3 | 0.588 |
EPHB4 |
0.674 | -0.049 | -1 | 0.838 |
PINK1_TYR |
0.674 | -0.130 | 1 | 0.678 |
CDK19 |
0.672 | -0.030 | 1 | 0.491 |
CK1A2 |
0.672 | -0.063 | -3 | 0.315 |
INSRR |
0.671 | -0.046 | 3 | 0.543 |
MST1R |
0.671 | -0.112 | 3 | 0.582 |
TTBK1 |
0.671 | -0.142 | 2 | 0.425 |
TYRO3 |
0.671 | -0.116 | 3 | 0.551 |
SRMS |
0.670 | -0.036 | 1 | 0.709 |
TYK2 |
0.670 | -0.139 | 1 | 0.632 |
ROS1 |
0.669 | -0.114 | 3 | 0.530 |
CK1E |
0.668 | -0.057 | -3 | 0.344 |
EPHA4 |
0.668 | -0.043 | 2 | 0.640 |
CSF1R |
0.668 | -0.117 | 3 | 0.567 |
DDR2 |
0.668 | 0.055 | 3 | 0.543 |
LIMK1_TYR |
0.667 | -0.153 | 2 | 0.645 |
EPHB1 |
0.667 | -0.058 | 1 | 0.695 |
YES1 |
0.667 | -0.081 | -1 | 0.821 |
PAK4 |
0.667 | 0.121 | -2 | 0.693 |
JAK2 |
0.666 | -0.162 | 1 | 0.638 |
NEK10_TYR |
0.665 | -0.031 | 1 | 0.595 |
YANK3 |
0.665 | -0.093 | 2 | 0.301 |
TXK |
0.665 | -0.011 | 1 | 0.732 |
PKG1 |
0.665 | 0.079 | -2 | 0.652 |
ABL2 |
0.665 | -0.089 | -1 | 0.784 |
FER |
0.665 | -0.122 | 1 | 0.715 |
EPHB3 |
0.664 | -0.069 | -1 | 0.830 |
EPHB2 |
0.664 | -0.064 | -1 | 0.822 |
AXL |
0.664 | -0.064 | 3 | 0.584 |
TNK2 |
0.664 | -0.073 | 3 | 0.568 |
JAK3 |
0.664 | -0.125 | 1 | 0.632 |
FGFR2 |
0.664 | -0.096 | 3 | 0.592 |
FGR |
0.663 | -0.123 | 1 | 0.681 |
FGFR1 |
0.662 | -0.110 | 3 | 0.573 |
ABL1 |
0.660 | -0.107 | -1 | 0.781 |
MERTK |
0.660 | -0.075 | 3 | 0.574 |
KIT |
0.660 | -0.126 | 3 | 0.570 |
PTK2B |
0.659 | -0.017 | -1 | 0.781 |
HCK |
0.659 | -0.140 | -1 | 0.776 |
EPHA3 |
0.659 | -0.070 | 2 | 0.599 |
BLK |
0.659 | -0.077 | -1 | 0.777 |
TEK |
0.659 | -0.147 | 3 | 0.521 |
TNK1 |
0.658 | -0.077 | 3 | 0.532 |
EPHA7 |
0.658 | -0.059 | 2 | 0.612 |
KDR |
0.658 | -0.104 | 3 | 0.553 |
LCK |
0.658 | -0.107 | -1 | 0.769 |
TNNI3K_TYR |
0.658 | -0.084 | 1 | 0.610 |
JAK1 |
0.658 | -0.104 | 1 | 0.591 |
FLT3 |
0.657 | -0.154 | 3 | 0.546 |
TEC |
0.657 | -0.080 | -1 | 0.717 |
LTK |
0.657 | -0.083 | 3 | 0.528 |
PDGFRB |
0.657 | -0.154 | 3 | 0.564 |
EPHA5 |
0.657 | -0.037 | 2 | 0.620 |
FGFR3 |
0.657 | -0.091 | 3 | 0.581 |
ALK |
0.657 | -0.099 | 3 | 0.509 |
EPHA1 |
0.655 | -0.094 | 3 | 0.559 |
ITK |
0.655 | -0.117 | -1 | 0.771 |
MET |
0.655 | -0.116 | 3 | 0.569 |
NTRK2 |
0.655 | -0.124 | 3 | 0.573 |
BMX |
0.655 | -0.073 | -1 | 0.686 |
INSR |
0.654 | -0.105 | 3 | 0.518 |
NTRK1 |
0.654 | -0.130 | -1 | 0.816 |
YANK2 |
0.653 | -0.114 | 2 | 0.312 |
KIS |
0.653 | -0.030 | 1 | 0.551 |
FYN |
0.650 | -0.086 | -1 | 0.728 |
PDGFRA |
0.650 | -0.195 | 3 | 0.559 |
ERBB2 |
0.649 | -0.151 | 1 | 0.613 |
BTK |
0.648 | -0.186 | -1 | 0.747 |
NTRK3 |
0.648 | -0.112 | -1 | 0.777 |
EPHA8 |
0.647 | -0.093 | -1 | 0.773 |
LYN |
0.647 | -0.143 | 3 | 0.496 |
FLT4 |
0.647 | -0.152 | 3 | 0.544 |
WEE1_TYR |
0.647 | -0.126 | -1 | 0.745 |
PTK6 |
0.646 | -0.167 | -1 | 0.726 |
FRK |
0.646 | -0.142 | -1 | 0.783 |
CK1G3 |
0.645 | -0.045 | -3 | 0.207 |
PTK2 |
0.645 | -0.023 | -1 | 0.680 |
FLT1 |
0.645 | -0.144 | -1 | 0.767 |
FGFR4 |
0.642 | -0.096 | -1 | 0.755 |
EGFR |
0.642 | -0.088 | 1 | 0.538 |
CSK |
0.642 | -0.124 | 2 | 0.611 |
SRC |
0.642 | -0.124 | -1 | 0.750 |
EPHA2 |
0.642 | -0.082 | -1 | 0.730 |
CK1G1 |
0.640 | -0.079 | -3 | 0.338 |
MATK |
0.639 | -0.138 | -1 | 0.730 |
IGF1R |
0.637 | -0.120 | 3 | 0.478 |
SYK |
0.636 | -0.067 | -1 | 0.684 |
ERBB4 |
0.634 | -0.084 | 1 | 0.567 |
MUSK |
0.629 | -0.145 | 1 | 0.517 |
FES |
0.625 | -0.119 | -1 | 0.679 |
CK1A |
0.611 | -0.063 | -3 | 0.239 |
ZAP70 |
0.610 | -0.105 | -1 | 0.630 |
CK1G2 |
0.603 | -0.102 | -3 | 0.278 |