Motif 11 (n=187)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NDB9 | PALM3 | S420 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| A6NFI3 | ZNF316 | S112 | ochoa | Zinc finger protein 316 | May be involved in transcriptional regulation. {ECO:0000250}. |
| O00178 | GTPBP1 | S69 | ochoa | GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) | Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). {ECO:0000250|UniProtKB:D2XV59}. |
| O00257 | CBX4 | S349 | ochoa | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250|UniProtKB:O55187, ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21282530}. |
| O00515 | LAD1 | S177 | ochoa | Ladinin-1 (Lad-1) (Linear IgA disease antigen) (LADA) | Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}. |
| O14976 | GAK | S834 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15014 | ZNF609 | S252 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15014 | ZNF609 | S758 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O15234 | CASC3 | S117 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| O15417 | TNRC18 | S1857 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43432 | EIF4G3 | S1409 | ochoa | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}. |
| O43491 | EPB41L2 | S798 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O43572 | AKAP10 | S52 | ochoa | A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10) | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}. |
| O43719 | HTATSF1 | S453 | ochoa | 17S U2 SnRNP complex component HTATSF1 (HIV Tat-specific factor 1) (Tat-SF1) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). {ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:30567737, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310, ECO:0000269|PubMed:35597237}.; FUNCTION: (Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
| O60268 | KIAA0513 | S279 | ochoa | Uncharacterized protein KIAA0513 | None |
| O75391 | SPAG7 | S158 | ochoa | Sperm-associated antigen 7 | None |
| O94782 | USP1 | S398 | ochoa | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment] | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604, ECO:0000269|PubMed:20147293, ECO:0000269|PubMed:26388029}. |
| O94819 | KBTBD11 | S107 | ochoa | Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B) | None |
| O94842 | TOX4 | S567 | ochoa | TOX high mobility group box family member 4 | Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). {ECO:0000250|UniProtKB:Q8BU11, ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240}. |
| O95197 | RTN3 | S575 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
| P07197 | NEFM | S511 | ochoa | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P08553}. |
| P07814 | EPRS1 | S547 | ochoa | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P0C7X2 | ZNF688 | S131 | ochoa | Zinc finger protein 688 | May be involved in transcriptional regulation. |
| P10072 | ZNF875 | S220 | ochoa | Zinc finger protein 875 (Krueppel-related zinc finger protein 1) (Protein HKR1) | May be involved in transcriptional regulation. |
| P10242 | MYB | S532 | ochoa|psp | Transcriptional activator Myb (Proto-oncogene c-Myb) | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| P11137 | MAP2 | S788 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11137 | MAP2 | S1347 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11137 | MAP2 | S1353 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11142 | HSPA8 | S541 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P12036 | NEFH | S503 | ochoa|psp | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S511 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S526 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S532 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S540 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S546 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S566 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S620 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S668 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S710 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P12036 | NEFH | S801 | ochoa | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
| P14635 | CCNB1 | S116 | psp | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P14635 | CCNB1 | S126 | psp | G2/mitotic-specific cyclin-B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811}. |
| P15408 | FOSL2 | S194 | ochoa | Fos-related antigen 2 (FRA-2) | Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniProtKB:P51145}. |
| P17677 | GAP43 | S151 | ochoa | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46) | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:21152083}. |
| P22670 | RFX1 | S949 | ochoa | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P23588 | EIF4B | S459 | ochoa | Eukaryotic translation initiation factor 4B (eIF-4B) | Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. |
| P33240 | CSTF2 | S113 | ochoa | Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) | One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269|PubMed:32816001, ECO:0000269|PubMed:9199325}. |
| P35251 | RFC1 | S360 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P42858 | HTT | S2651 | ochoa | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P46100 | ATRX | S1527 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46821 | MAP1B | S970 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48681 | NES | S842 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S905 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S229 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49321 | NASP | S451 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49643 | PRIM2 | S170 | ochoa | DNA primase large subunit (DNA primase 58 kDa subunit) (p58) | Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:17893144, PubMed:25550159, PubMed:26975377, PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144, PubMed:25550159). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch. {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P33610, ECO:0000269|PubMed:17893144, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:9705292}. |
| P52746 | ZNF142 | S962 | ochoa | Zinc finger protein 142 | May be involved in transcriptional regulation. {ECO:0000305}. |
| P53814 | SMTN | S576 | ochoa | Smoothelin | Structural protein of the cytoskeleton. |
| P55201 | BRPF1 | S238 | ochoa | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27939640}. |
| P55347 | PKNOX1 | S41 | ochoa | Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1) | Activates transcription in the presence of PBX1A and HOXA1. {ECO:0000250|UniProtKB:O70477}. |
| P56211 | ARPP19 | S23 | ochoa | cAMP-regulated phosphoprotein 19 (ARPP-19) | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:38123684}. |
| P78332 | RBM6 | S353 | ochoa | RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3) | Specifically binds poly(G) RNA homopolymers in vitro. |
| P78559 | MAP1A | S1600 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Q01484 | ANK2 | S2127 | ochoa | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}. |
| Q01804 | OTUD4 | S443 | ochoa | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066}. |
| Q02040 | AKAP17A | S537 | ochoa | A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A) | Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}. |
| Q02952 | AKAP12 | S283 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S286 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q02952 | AKAP12 | S1331 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03001 | DST | S3123 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03164 | KMT2A | S2098 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q07866 | KLC1 | S162 | ochoa | Kinesin light chain 1 (KLC 1) | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (PubMed:21385839). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:0000250|UniProtKB:P37285, ECO:0000269|PubMed:21385839}. |
| Q08050 | FOXM1 | S481 | ochoa | Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells) | Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036). {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}. |
| Q0VDD7 | BRME1 | S476 | ochoa | Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3) | Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. {ECO:0000250|UniProtKB:Q6DIA7}. |
| Q0ZGT2 | NEXN | S357 | ochoa | Nexilin (F-actin-binding protein) (Nelin) | Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Q12830 | BPTF | S572 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q13188 | STK3 | S385 | ochoa|psp | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| Q13342 | SP140 | S291 | ochoa | Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). {ECO:0000269|PubMed:24267382, ECO:0000269|PubMed:8910577, ECO:0000303|PubMed:8910577}. |
| Q13428 | TCOF1 | S777 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14151 | SAFB2 | S343 | ochoa | Scaffold attachment factor B2 (SAF-B2) | Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation. |
| Q14542 | SLC29A2 | S252 | ochoa | Equilibrative nucleoside transporter 2 (hENT2) (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2) | Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Functions as a Na(+)-independent, passive transporter (PubMed:9478986). Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine (PubMed:10722669, PubMed:12527552, PubMed:12590919, PubMed:16214850, PubMed:21795683, PubMed:9396714, PubMed:9478986). Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:16214850, PubMed:21795683). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites (PubMed:12527552). Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (PubMed:23639800). Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity). {ECO:0000250|UniProtKB:O54699, ECO:0000269|PubMed:10722669, ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:12590919, ECO:0000269|PubMed:16214850, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:23639800, ECO:0000269|PubMed:9396714, ECO:0000269|PubMed:9478986}.; FUNCTION: [Isoform 3]: Non functional nucleoside transporter protein for adenosine or thymidine transport. Does not express on cell membrane. {ECO:0000269|PubMed:12527552}. |
| Q14566 | MCM6 | S689 | ochoa | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| Q15424 | SAFB | S344 | ochoa | Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) | Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}. |
| Q2TAZ0 | ATG2A | S775 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q3KQU3 | MAP7D1 | S753 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q3L8U1 | CHD9 | S2079 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q5JRX3 | PITRM1 | S530 | ochoa | Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1) | Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469, PubMed:26697887). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469, PubMed:29383861, PubMed:29764912). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469). It is also able to degrade amyloid-beta protein 42 (PubMed:29764912). {ECO:0000269|PubMed:10360838, ECO:0000269|PubMed:16849325, ECO:0000269|PubMed:19196155, ECO:0000269|PubMed:24931469, ECO:0000269|PubMed:26697887, ECO:0000269|PubMed:29383861, ECO:0000269|PubMed:29764912}. |
| Q5JSH3 | WDR44 | S27 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5T1V6 | DDX59 | S76 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q5VST9 | OBSCN | S7244 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VUA4 | ZNF318 | S1243 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VWG9 | TAF3 | S183 | ochoa | Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140) | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF3 forms the TFIID-A module together with TAF5 and TBP (PubMed:33795473). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:11438666). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:11438666). {ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:33795473}. |
| Q5VZK9 | CARMIL1 | S1151 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q63HK5 | TSHZ3 | S644 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q6IN85 | PPP4R3A | S698 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}. |
| Q6JBY9 | RCSD1 | S298 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6NWY9 | PRPF40B | S832 | ochoa | Pre-mRNA-processing factor 40 homolog B (Huntingtin yeast partner C) (Huntingtin-interacting protein C) | May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:9700202}. |
| Q6NZY4 | ZCCHC8 | S598 | ochoa | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:31488579, ECO:0000305|PubMed:16263084}. |
| Q6P0Q8 | MAST2 | S846 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6PJT7 | ZC3H14 | S274 | ochoa | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs (PubMed:39461343). Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome (PubMed:39461343). Required for spermatogenesis via involvement in circRNA biogenesis (PubMed:39461343). Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation (PubMed:27563065). Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells (PubMed:17630287, PubMed:24671764). {ECO:0000269|PubMed:17630287, ECO:0000269|PubMed:24671764, ECO:0000269|PubMed:27563065, ECO:0000269|PubMed:39461343}. |
| Q6ZSZ6 | TSHZ1 | S62 | ochoa | Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33) | Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). {ECO:0000305}. |
| Q71RC2 | LARP4 | S647 | ochoa | La-related protein 4 (La ribonucleoprotein domain family member 4) | RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744). {ECO:0000269|PubMed:21098120, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:27615744}. |
| Q7Z6I6 | ARHGAP30 | S822 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86U42 | PABPN1 | S150 | ochoa | Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). {ECO:0000250|UniProtKB:Q28165, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:27871484}. |
| Q86UB2 | BIVM | S24 | ochoa | Basic immunoglobulin-like variable motif-containing protein | None |
| Q86US8 | SMG6 | S831 | ochoa | Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a) | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629). {ECO:0000269|PubMed:12676087, ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:19179534}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PubMed:17053788, PubMed:18974281, PubMed:19060897, PubMed:20930030). {ECO:0000269|PubMed:17053788, ECO:0000269|PubMed:18974281, ECO:0000269|PubMed:19060897, ECO:0000269|PubMed:20930030}. |
| Q86UW6 | N4BP2 | S607 | ochoa | NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) | Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. {ECO:0000269|PubMed:12730195}. |
| Q8IVF2 | AHNAK2 | S5741 | ochoa | Protein AHNAK2 | None |
| Q8IWC1 | MAP7D3 | S441 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IX01 | SUGP2 | S887 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8IYI6 | EXOC8 | S372 | ochoa | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
| Q8IZD4 | DCP1B | S67 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8N302 | AGGF1 | S329 | ochoa | Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein) | Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}. |
| Q8N3F8 | MICALL1 | S447 | ochoa | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation (PubMed:19864458, PubMed:20801876, PubMed:23596323, PubMed:34100897). Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking (PubMed:21795389). Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane (PubMed:19864458). Also involved in cargo protein delivery to the plasma membrane (PubMed:34100897). Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (PubMed:31615969). May indirectly play a role in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q8BGT6, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:21795389, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:31615969, ECO:0000269|PubMed:34100897}. |
| Q8N3X1 | FNBP4 | S508 | ochoa | Formin-binding protein 4 (Formin-binding protein 30) | None |
| Q8NDI1 | EHBP1 | S295 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8TCN5 | ZNF507 | S388 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TDY2 | RB1CC1 | S243 | ochoa | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9ESK9, ECO:0000269|PubMed:10769033, ECO:0000269|PubMed:12095676, ECO:0000269|PubMed:12163359, ECO:0000269|PubMed:12221124, ECO:0000269|PubMed:14533007, ECO:0000269|PubMed:21775823, ECO:0000269|PubMed:23392225}. |
| Q8TEV9 | SMCR8 | S562 | psp | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8TF01 | PNISR | S311 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8TF01 | PNISR | S313 | ochoa | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | None |
| Q8WXH0 | SYNE2 | S4136 | ochoa | Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250|UniProtKB:Q6ZWQ0, ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:22945352, ECO:0000269|PubMed:34818527}. |
| Q92539 | LPIN2 | S106 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92598 | HSPH1 | S809 | ochoa | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| Q92766 | RREB1 | S1225 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92793 | CREBBP | S1076 | ochoa | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | Acetylates histones, giving a specific tag for transcriptional activation (PubMed:21131905, PubMed:24616510). Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) (PubMed:21131905). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:24207024, PubMed:28790157, PubMed:30540930, PubMed:35675826, PubMed:9707565). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation (PubMed:38128537). Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38128537). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:21131905, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:35675826, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9707565}. |
| Q92889 | ERCC4 | S521 | ochoa | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. {ECO:0000269|PubMed:10413517, ECO:0000269|PubMed:11790111, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:24027083, ECO:0000269|PubMed:32034146, ECO:0000269|PubMed:8797827}. |
| Q93074 | MED12 | S698 | ochoa | Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. {ECO:0000269|PubMed:16565090, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:17000779}. |
| Q969G3 | SMARCE1 | S136 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. {ECO:0000250|UniProtKB:O54941, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q969R5 | L3MBTL2 | S73 | ochoa | Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2) | Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}. |
| Q96BJ3 | AIDA | S144 | ochoa | Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist) | Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). {ECO:0000250}. |
| Q96CV9 | OPTN | S198 | ochoa | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431). Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment (PubMed:22854040). Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000269|PubMed:11834836, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:20085643, ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:27534431, ECO:0000269|PubMed:27538435}.; FUNCTION: (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response (PubMed:27538435, PubMed:9488477). During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1 (PubMed:20174559). {ECO:0000269|PubMed:20174559, ECO:0000269|PubMed:27538435, ECO:0000269|PubMed:9488477}. |
| Q96M96 | FGD4 | S186 | ochoa | FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6) | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15133042}. |
| Q96NY7 | CLIC6 | S112 | ochoa | Chloride intracellular channel protein 6 (Glutaredoxin-like oxidoreductase CLIC6) (EC 1.8.-.-) (Parchorin) | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:37838179}. |
| Q96PY6 | NEK1 | S837 | ochoa | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617). {ECO:0000250|UniProtKB:P51954, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:21211617}. |
| Q96SB4 | SRPK1 | S311 | ochoa | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q96ST3 | SIN3A | S1112 | ochoa | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Q96T58 | SPEN | S1983 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q96T88 | UHRF1 | S639 | ochoa|psp | E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) | Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF2 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation. Acts as a critical player of proper spindle architecture by catalyzing the 'Lys-63'-linked ubiquitination of KIF11, thereby controlling KIF11 localization on the spindle (PubMed:37728657). {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:15009091, ECO:0000269|PubMed:15361834, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:21777816, ECO:0000269|PubMed:22945642, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:37728657}. |
| Q99728 | BARD1 | S288 | psp | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
| Q9C073 | FAM117A | S306 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C073 | FAM117A | S355 | ochoa | Protein FAM117A (C/EBP-induced protein) | None |
| Q9C0C2 | TNKS1BP1 | S1503 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0C9 | UBE2O | S431 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0C9 | UBE2O | S896 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9H0B6 | KLC2 | S151 | ochoa | Kinesin light chain 2 (KLC 2) | Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends (PubMed:22172677). {ECO:0000269|PubMed:22172677, ECO:0000305|PubMed:22172677}. |
| Q9H1E3 | NUCKS1 | S223 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H3Q1 | CDC42EP4 | S142 | ochoa | Cdc42 effector protein 4 (Binder of Rho GTPases 4) | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. |
| Q9H4I2 | ZHX3 | S723 | ochoa | Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3) | Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Q9H7U1 | CCSER2 | S452 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H892 | TTC12 | S67 | ochoa | Tetratricopeptide repeat protein 12 (TPR repeat protein 12) | Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella. {ECO:0000269|PubMed:31978331}. |
| Q9H8Y5 | ANKZF1 | S398 | ochoa | tRNA endonuclease ANKZF1 (EC 3.1.-.-) (Ankyrin repeat and zinc finger domain-containing protein 1) (Zinc finger protein 744) | Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation (PubMed:29632312, PubMed:30244831, PubMed:31011209). The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts (PubMed:29632312, PubMed:30244831, PubMed:31011209). ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs (PubMed:31011209). ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1 (PubMed:31011209, PubMed:32075755). Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). {ECO:0000269|PubMed:28302725, ECO:0000269|PubMed:29632312, ECO:0000269|PubMed:30244831, ECO:0000269|PubMed:31011209, ECO:0000269|PubMed:32075755}. |
| Q9HAU0 | PLEKHA5 | S1037 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HCM7 | FBRSL1 | S141 | ochoa | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | None |
| Q9NQV5 | PRDM11 | S426 | ochoa | PR domain-containing protein 11 (EC 2.1.1.-) | May be involved in transcription regulation. {ECO:0000269|PubMed:25499759}. |
| Q9NS91 | RAD18 | S158 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NS91 | RAD18 | S471 | ochoa | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}. |
| Q9NUA8 | ZBTB40 | S160 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NUA8 | ZBTB40 | S621 | ochoa | Zinc finger and BTB domain-containing protein 40 | May be involved in transcriptional regulation. |
| Q9NV56 | MRGBP | S23 | ochoa | MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4) | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Q9NVM9 | INTS13 | S626 | ochoa | Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS13 is part of the integrator tail module and acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). At prophase, mediates recruitment of cytoplasmic dynein to the nuclear envelope, a step important for proper centrosome-nucleus coupling (PubMed:23097494, PubMed:23904267). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (PubMed:23097494, PubMed:23904267). {ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386, ECO:0000269|PubMed:38906142}. |
| Q9NVU0 | POLR3E | S522 | ochoa | DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide) | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:12391170, PubMed:20413673, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Assembles with POLR3D/RPC4 forming a subcomplex that binds the Pol III core. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity) (PubMed:12391170, PubMed:20413673, PubMed:35637192). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:P36121, ECO:0000269|PubMed:12391170, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:35637192}. |
| Q9NW68 | BSDC1 | S235 | ochoa | BSD domain-containing protein 1 | None |
| Q9NY27 | PPP4R2 | S226 | ochoa | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair. {ECO:0000269|PubMed:10769191, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:20154705}. |
| Q9NYD6 | HOXC10 | S189 | ochoa | Homeobox protein Hox-C10 (Homeobox protein Hox-3I) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Q9P0V3 | SH3BP4 | S877 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P2D1 | CHD7 | S1874 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2D1 | CHD7 | S2213 | ochoa | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| Q9P2N5 | RBM27 | S120 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269|PubMed:31950173}. |
| Q9UBW5 | BIN2 | S498 | ochoa | Bridging integrator 2 (Breast cancer-associated protein 1) | Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}. |
| Q9UK97 | FBXO9 | S33 | ochoa | F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability (PubMed:23263282, PubMed:34480022). Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (PubMed:23263282). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (PubMed:34480022). Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BK06, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:34480022}. |
| Q9UKT9 | IKZF3 | S378 | ochoa|psp | Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:34155405}. |
| Q9UKV3 | ACIN1 | S386 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9UKV5 | AMFR | S542 | ochoa | E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78) | E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation (PubMed:10456327, PubMed:11724934, PubMed:12670940, PubMed:19103148, PubMed:24424410, PubMed:28604676). Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) (PubMed:10456327, PubMed:11724934, PubMed:19103148, PubMed:24424410). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane (PubMed:16168377, PubMed:22143767). In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:16168377, PubMed:22143767, PubMed:23223569). In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low (PubMed:28604676). Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols (PubMed:17043353). Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation (PubMed:31953408). Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex (PubMed:21636303). Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation (PubMed:21636303). Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor (PubMed:10456327). In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation (PubMed:36593296). Required for proper lipid homeostasis (PubMed:37119330). {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:12670940, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:17043353, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:21636303, ECO:0000269|PubMed:22143767, ECO:0000269|PubMed:23223569, ECO:0000269|PubMed:24424410, ECO:0000269|PubMed:28604676, ECO:0000269|PubMed:31073040, ECO:0000269|PubMed:31953408, ECO:0000269|PubMed:36593296, ECO:0000269|PubMed:37119330}. |
| Q9ULD9 | ZNF608 | S1453 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9UPQ0 | LIMCH1 | S718 | ochoa | LIM and calponin homology domains-containing protein 1 | Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269|PubMed:28228547}. |
| Q9UPV0 | CEP164 | S566 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9Y2H9 | MAST1 | S708 | ochoa | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250|UniProtKB:Q9R1L5, ECO:0000269|PubMed:30449657}. |
| Q9Y2I6 | NINL | S185 | psp | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Q9Y3T9 | NOC2L | S49 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y4F1 | FARP1 | S863 | ochoa | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}. |
| Q9Y4J8 | DTNA | S662 | ochoa | Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3) | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Q9Y666 | SLC12A7 | S50 | ochoa | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| R4GMW8 | BIVM-ERCC5 | S24 | ochoa | DNA excision repair protein ERCC-5 | None |
| U3KPZ7 | LOC127814297 | S120 | ochoa | RNA-binding protein 27 (RNA-binding motif protein 27) | May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256|ARBA:ARBA00043866}. |
| Q13162 | PRDX4 | Y60 | Sugiyama | Peroxiredoxin-4 (EC 1.11.1.24) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) (Thioredoxin-dependent peroxiredoxin 4) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}. |
| P12036 | NEFH | S518 | SIGNOR|iPTMNet | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). {ECO:0000250|UniProtKB:P19246}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.011873 | 1.925 |
| R-HSA-69091 | Polymerase switching | 0.013414 | 1.872 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.013414 | 1.872 |
| R-HSA-69109 | Leading Strand Synthesis | 0.013414 | 1.872 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.004472 | 2.349 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.002130 | 2.672 |
| R-HSA-69190 | DNA strand elongation | 0.008534 | 2.069 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 0.007762 | 2.110 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.003526 | 2.453 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.012693 | 1.896 |
| R-HSA-9930044 | Nuclear RNA decay | 0.009154 | 2.038 |
| R-HSA-69275 | G2/M Transition | 0.007523 | 2.124 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.007910 | 2.102 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.004097 | 2.388 |
| R-HSA-1640170 | Cell Cycle | 0.006250 | 2.204 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.005822 | 2.235 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.003338 | 2.476 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.005640 | 2.249 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.021502 | 1.668 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.021502 | 1.668 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.021502 | 1.668 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 0.021502 | 1.668 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.021502 | 1.668 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 0.021502 | 1.668 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.021502 | 1.668 |
| R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 0.063136 | 1.200 |
| R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 0.073267 | 1.135 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.073267 | 1.135 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 0.093202 | 1.031 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 0.093202 | 1.031 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 0.122308 | 0.913 |
| R-HSA-9613354 | Lipophagy | 0.122308 | 0.913 |
| R-HSA-68952 | DNA replication initiation | 0.131802 | 0.880 |
| R-HSA-429947 | Deadenylation of mRNA | 0.042744 | 1.369 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.159675 | 0.797 |
| R-HSA-69166 | Removal of the Flap Intermediate | 0.177762 | 0.750 |
| R-HSA-73780 | RNA Polymerase III Chain Elongation | 0.186659 | 0.729 |
| R-HSA-72187 | mRNA 3'-end processing | 0.028290 | 1.548 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.195461 | 0.709 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.073969 | 1.131 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.204168 | 0.690 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.221302 | 0.655 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.221302 | 0.655 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.043052 | 1.366 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.043052 | 1.366 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 0.229731 | 0.639 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.229731 | 0.639 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.047629 | 1.322 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.238069 | 0.623 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.238069 | 0.623 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.238069 | 0.623 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.238069 | 0.623 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.238069 | 0.623 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.059193 | 1.228 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.254477 | 0.594 |
| R-HSA-380287 | Centrosome maturation | 0.062718 | 1.203 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.286247 | 0.543 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.089972 | 1.046 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.301623 | 0.521 |
| R-HSA-9615710 | Late endosomal microautophagy | 0.316670 | 0.499 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.316670 | 0.499 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.202727 | 0.693 |
| R-HSA-1989781 | PPARA activates gene expression | 0.290728 | 0.537 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.124578 | 0.905 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 0.168768 | 0.773 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.033016 | 1.481 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.047960 | 1.319 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.059036 | 1.229 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.094212 | 1.026 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.316670 | 0.499 |
| R-HSA-73893 | DNA Damage Bypass | 0.024827 | 1.605 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 0.186659 | 0.729 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.177762 | 0.750 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.022307 | 1.652 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.177762 | 0.750 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.186659 | 0.729 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.186659 | 0.729 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.073860 | 1.132 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.022307 | 1.652 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.186659 | 0.729 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.229731 | 0.639 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.286247 | 0.543 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.286247 | 0.543 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 0.159675 | 0.797 |
| R-HSA-72172 | mRNA Splicing | 0.227640 | 0.643 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.026385 | 1.579 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.067860 | 1.168 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.050808 | 1.294 |
| R-HSA-3371568 | Attenuation phase | 0.015047 | 1.823 |
| R-HSA-69239 | Synthesis of DNA | 0.140729 | 0.852 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 0.150484 | 0.823 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.096615 | 1.015 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.142804 | 0.845 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.161621 | 0.792 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.165438 | 0.781 |
| R-HSA-5693538 | Homology Directed Repair | 0.015218 | 1.818 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.109187 | 0.962 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.196477 | 0.707 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.287784 | 0.541 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.111961 | 0.951 |
| R-HSA-168315 | Inhibition of Host mRNA Processing and RNA Silencing | 0.032080 | 1.494 |
| R-HSA-9022538 | Loss of MECP2 binding ability to 5mC-DNA | 0.052896 | 1.277 |
| R-HSA-176417 | Phosphorylation of Emi1 | 0.083288 | 1.079 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.112710 | 0.948 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 0.028529 | 1.545 |
| R-HSA-176974 | Unwinding of DNA | 0.122308 | 0.913 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 0.150484 | 0.823 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.045324 | 1.344 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 0.159675 | 0.797 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.027109 | 1.567 |
| R-HSA-176412 | Phosphorylation of the APC/C | 0.195461 | 0.709 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.037313 | 1.428 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.040130 | 1.397 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 0.254477 | 0.594 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.262549 | 0.581 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.262549 | 0.581 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.126045 | 0.899 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.039892 | 1.399 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.221302 | 0.655 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.157821 | 0.802 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.196477 | 0.707 |
| R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 0.159675 | 0.797 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.112710 | 0.948 |
| R-HSA-5334118 | DNA methylation | 0.316670 | 0.499 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.212258 | 0.673 |
| R-HSA-69306 | DNA Replication | 0.284842 | 0.545 |
| R-HSA-3371556 | Cellular response to heat stress | 0.060799 | 1.216 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.042744 | 1.369 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.067860 | 1.168 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 0.262549 | 0.581 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.079739 | 1.098 |
| R-HSA-68877 | Mitotic Prometaphase | 0.200505 | 0.698 |
| R-HSA-68875 | Mitotic Prophase | 0.179689 | 0.745 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.034870 | 1.458 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.186659 | 0.729 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.228158 | 0.642 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.264171 | 0.578 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.067860 | 1.168 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.112710 | 0.948 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.150484 | 0.823 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 0.150484 | 0.823 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.204168 | 0.690 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.099995 | 1.000 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.246318 | 0.609 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.060944 | 1.215 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 0.278433 | 0.555 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.293977 | 0.532 |
| R-HSA-73894 | DNA Repair | 0.122130 | 0.913 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.309188 | 0.510 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.124509 | 0.905 |
| R-HSA-9909396 | Circadian clock | 0.218342 | 0.661 |
| R-HSA-9843745 | Adipogenesis | 0.215523 | 0.667 |
| R-HSA-157579 | Telomere Maintenance | 0.114265 | 0.942 |
| R-HSA-69481 | G2/M Checkpoints | 0.070334 | 1.153 |
| R-HSA-69242 | S Phase | 0.270178 | 0.568 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 0.093202 | 1.031 |
| R-HSA-9612973 | Autophagy | 0.293674 | 0.532 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.204168 | 0.690 |
| R-HSA-68886 | M Phase | 0.275313 | 0.560 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.027514 | 1.560 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.216224 | 0.665 |
| R-HSA-73886 | Chromosome Maintenance | 0.182386 | 0.739 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 0.093202 | 1.031 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.103009 | 0.987 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 0.103009 | 0.987 |
| R-HSA-8866907 | Activation of the TFAP2 (AP-2) family of transcription factors | 0.122308 | 0.913 |
| R-HSA-9022702 | MECP2 regulates transcription of neuronal ligands | 0.131802 | 0.880 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 0.150484 | 0.823 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 0.195461 | 0.709 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.286247 | 0.543 |
| R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma ... | 0.301623 | 0.521 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.248141 | 0.605 |
| R-HSA-1632852 | Macroautophagy | 0.246917 | 0.607 |
| R-HSA-4839726 | Chromatin organization | 0.170536 | 0.768 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.192554 | 0.715 |
| R-HSA-983189 | Kinesins | 0.038708 | 1.412 |
| R-HSA-180786 | Extension of Telomeres | 0.165438 | 0.781 |
| R-HSA-8953854 | Metabolism of RNA | 0.141403 | 0.850 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 0.073267 | 1.135 |
| R-HSA-447041 | CHL1 interactions | 0.103009 | 0.987 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.159675 | 0.797 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.159675 | 0.797 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.159675 | 0.797 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.168768 | 0.773 |
| R-HSA-2028269 | Signaling by Hippo | 0.212781 | 0.672 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.221302 | 0.655 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.238069 | 0.623 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 0.113830 | 0.944 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.301623 | 0.521 |
| R-HSA-3214847 | HATs acetylate histones | 0.118925 | 0.925 |
| R-HSA-5617833 | Cilium Assembly | 0.193881 | 0.712 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.085815 | 1.066 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.278433 | 0.555 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.111961 | 0.951 |
| R-HSA-9663891 | Selective autophagy | 0.284212 | 0.546 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.186855 | 0.728 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 0.168768 | 0.773 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.204168 | 0.690 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.293977 | 0.532 |
| R-HSA-69206 | G1/S Transition | 0.196027 | 0.708 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.293977 | 0.532 |
| R-HSA-74160 | Gene expression (Transcription) | 0.185008 | 0.733 |
| R-HSA-9833110 | RSV-host interactions | 0.133316 | 0.875 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 0.177762 | 0.750 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.067860 | 1.168 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.254477 | 0.594 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.154039 | 0.812 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.301623 | 0.521 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.212258 | 0.673 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.150484 | 0.823 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.204168 | 0.690 |
| R-HSA-9834899 | Specification of the neural plate border | 0.229731 | 0.639 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.246318 | 0.609 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.167193 | 0.777 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.221302 | 0.655 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.262549 | 0.581 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.246318 | 0.609 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.170812 | 0.767 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.059036 | 1.229 |
| R-HSA-8876725 | Protein methylation | 0.186659 | 0.729 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.246318 | 0.609 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 0.301623 | 0.521 |
| R-HSA-1483213 | Synthesis of PE | 0.301623 | 0.521 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.176980 | 0.752 |
| R-HSA-373760 | L1CAM interactions | 0.169018 | 0.772 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.218342 | 0.661 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.144686 | 0.840 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.296216 | 0.528 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.089958 | 1.046 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.042965 | 1.367 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.264336 | 0.578 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.130204 | 0.885 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.204168 | 0.690 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.268181 | 0.572 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.232548 | 0.633 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.111871 | 0.951 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.254477 | 0.594 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.301623 | 0.521 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.229731 | 0.639 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.262549 | 0.581 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.180855 | 0.743 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.240137 | 0.620 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.041797 | 1.379 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 0.023727 | 1.625 |
| R-HSA-264876 | Insulin processing | 0.301623 | 0.521 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.220196 | 0.657 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.244138 | 0.612 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.041797 | 1.379 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.073969 | 1.131 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.284212 | 0.546 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.064872 | 1.188 |
| R-HSA-75153 | Apoptotic execution phase | 0.117362 | 0.930 |
| R-HSA-73887 | Death Receptor Signaling | 0.287784 | 0.541 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.278333 | 0.555 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.088344 | 1.054 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.157821 | 0.802 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.278433 | 0.555 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.278433 | 0.555 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.077757 | 1.109 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.301623 | 0.521 |
| R-HSA-9707616 | Heme signaling | 0.176980 | 0.752 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.208300 | 0.681 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.187811 | 0.726 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.252147 | 0.598 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.324072 | 0.489 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.324072 | 0.489 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.324072 | 0.489 |
| R-HSA-112311 | Neurotransmitter clearance | 0.324072 | 0.489 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.331395 | 0.480 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.331395 | 0.480 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.335962 | 0.474 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.335962 | 0.474 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.338638 | 0.470 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.345804 | 0.461 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.345804 | 0.461 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.345804 | 0.461 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.347768 | 0.459 |
| R-HSA-212436 | Generic Transcription Pathway | 0.349225 | 0.457 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.352892 | 0.452 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 0.352892 | 0.452 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.352892 | 0.452 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.359505 | 0.444 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.359505 | 0.444 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.359904 | 0.444 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.359904 | 0.444 |
| R-HSA-5205647 | Mitophagy | 0.359904 | 0.444 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.359904 | 0.444 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 0.359904 | 0.444 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.359904 | 0.444 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.363400 | 0.440 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.365118 | 0.438 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.366841 | 0.436 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.366841 | 0.436 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.366841 | 0.436 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.366841 | 0.436 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.373702 | 0.427 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.373702 | 0.427 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.373702 | 0.427 |
| R-HSA-3371511 | HSF1 activation | 0.373702 | 0.427 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.373702 | 0.427 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.378891 | 0.421 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.380490 | 0.420 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.380490 | 0.420 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.387204 | 0.412 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.387204 | 0.412 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.390406 | 0.408 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.390406 | 0.408 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.393847 | 0.405 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.393847 | 0.405 |
| R-HSA-201556 | Signaling by ALK | 0.393847 | 0.405 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.393847 | 0.405 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 0.400417 | 0.397 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.400417 | 0.397 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.400417 | 0.397 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.406917 | 0.390 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 0.406917 | 0.390 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.406917 | 0.390 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.406917 | 0.390 |
| R-HSA-167161 | HIV Transcription Initiation | 0.413347 | 0.384 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 0.413347 | 0.384 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 0.413347 | 0.384 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.413347 | 0.384 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.413347 | 0.384 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.416896 | 0.380 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.419707 | 0.377 |
| R-HSA-165159 | MTOR signalling | 0.419707 | 0.377 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.425736 | 0.371 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 0.425999 | 0.371 |
| R-HSA-9710421 | Defective pyroptosis | 0.425999 | 0.371 |
| R-HSA-8854214 | TBC/RABGAPs | 0.425999 | 0.371 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.431774 | 0.365 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.432223 | 0.364 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.432223 | 0.364 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 0.438380 | 0.358 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.438380 | 0.358 |
| R-HSA-199991 | Membrane Trafficking | 0.442343 | 0.354 |
| R-HSA-9675135 | Diseases of DNA repair | 0.444470 | 0.352 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.444470 | 0.352 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 0.444470 | 0.352 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.444470 | 0.352 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.450086 | 0.347 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.450086 | 0.347 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.450086 | 0.347 |
| R-HSA-1483191 | Synthesis of PC | 0.450495 | 0.346 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.462351 | 0.335 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.462351 | 0.335 |
| R-HSA-9748787 | Azathioprine ADME | 0.468183 | 0.330 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.479659 | 0.319 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.479659 | 0.319 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.479659 | 0.319 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.479659 | 0.319 |
| R-HSA-1221632 | Meiotic synapsis | 0.485304 | 0.314 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.485304 | 0.314 |
| R-HSA-72649 | Translation initiation complex formation | 0.490888 | 0.309 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.496413 | 0.304 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.496413 | 0.304 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.501877 | 0.299 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.501877 | 0.299 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.501877 | 0.299 |
| R-HSA-75893 | TNF signaling | 0.501877 | 0.299 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.512630 | 0.290 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.512630 | 0.290 |
| R-HSA-8979227 | Triglyceride metabolism | 0.517920 | 0.286 |
| R-HSA-186712 | Regulation of beta-cell development | 0.517920 | 0.286 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.517920 | 0.286 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.523152 | 0.281 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.523152 | 0.281 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.523152 | 0.281 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.523152 | 0.281 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.523152 | 0.281 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.523152 | 0.281 |
| R-HSA-379724 | tRNA Aminoacylation | 0.523152 | 0.281 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.523152 | 0.281 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.523168 | 0.281 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.528328 | 0.277 |
| R-HSA-8939211 | ESR-mediated signaling | 0.530390 | 0.275 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.533448 | 0.273 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.533448 | 0.273 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.533448 | 0.273 |
| R-HSA-1268020 | Mitochondrial protein import | 0.533448 | 0.273 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.533448 | 0.273 |
| R-HSA-9758941 | Gastrulation | 0.542831 | 0.265 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.548479 | 0.261 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.548479 | 0.261 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.549081 | 0.260 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 0.553382 | 0.257 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.558785 | 0.253 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.563029 | 0.249 |
| R-HSA-167172 | Transcription of the HIV genome | 0.563029 | 0.249 |
| R-HSA-1266738 | Developmental Biology | 0.570051 | 0.244 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.577112 | 0.239 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.577112 | 0.239 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.577112 | 0.239 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.581706 | 0.235 |
| R-HSA-109581 | Apoptosis | 0.583484 | 0.234 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.586249 | 0.232 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.586249 | 0.232 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.586249 | 0.232 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.590744 | 0.229 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 0.590744 | 0.229 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.590744 | 0.229 |
| R-HSA-8852135 | Protein ubiquitination | 0.595190 | 0.225 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.595190 | 0.225 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.595190 | 0.225 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.595190 | 0.225 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.599589 | 0.222 |
| R-HSA-5689603 | UCH proteinases | 0.599589 | 0.222 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.603939 | 0.219 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.607449 | 0.216 |
| R-HSA-72306 | tRNA processing | 0.610042 | 0.215 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.615768 | 0.211 |
| R-HSA-9833482 | PKR-mediated signaling | 0.616711 | 0.210 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.616711 | 0.210 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.624997 | 0.204 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.637094 | 0.196 |
| R-HSA-1500620 | Meiosis | 0.637094 | 0.196 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.639400 | 0.194 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.641039 | 0.193 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.641039 | 0.193 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.644942 | 0.190 |
| R-HSA-70268 | Pyruvate metabolism | 0.648802 | 0.188 |
| R-HSA-109582 | Hemostasis | 0.651379 | 0.186 |
| R-HSA-73884 | Base Excision Repair | 0.660135 | 0.180 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.660135 | 0.180 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.663831 | 0.178 |
| R-HSA-1483257 | Phospholipid metabolism | 0.667414 | 0.176 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.669513 | 0.174 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.671104 | 0.173 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.674682 | 0.171 |
| R-HSA-1474290 | Collagen formation | 0.678221 | 0.169 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.681721 | 0.166 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.685184 | 0.164 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.688609 | 0.162 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.689257 | 0.162 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.691998 | 0.160 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.696408 | 0.157 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.696408 | 0.157 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.701944 | 0.154 |
| R-HSA-5357801 | Programmed Cell Death | 0.703424 | 0.153 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.708397 | 0.150 |
| R-HSA-1483255 | PI Metabolism | 0.708397 | 0.150 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.720888 | 0.142 |
| R-HSA-68882 | Mitotic Anaphase | 0.728008 | 0.138 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.729907 | 0.137 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.729907 | 0.137 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.730156 | 0.137 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.732848 | 0.135 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.735757 | 0.133 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.735757 | 0.133 |
| R-HSA-8951664 | Neddylation | 0.738604 | 0.132 |
| R-HSA-422475 | Axon guidance | 0.739539 | 0.131 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.744298 | 0.128 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.757926 | 0.120 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.757926 | 0.120 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.760564 | 0.119 |
| R-HSA-2980736 | Peptide hormone metabolism | 0.760564 | 0.119 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.765754 | 0.116 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.770833 | 0.113 |
| R-HSA-112316 | Neuronal System | 0.780728 | 0.107 |
| R-HSA-9675108 | Nervous system development | 0.787531 | 0.104 |
| R-HSA-114608 | Platelet degranulation | 0.787759 | 0.104 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.788223 | 0.103 |
| R-HSA-1474165 | Reproduction | 0.796868 | 0.099 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.803343 | 0.095 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.803443 | 0.095 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.815965 | 0.088 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.817338 | 0.088 |
| R-HSA-6807070 | PTEN Regulation | 0.817973 | 0.087 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.825792 | 0.083 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.825792 | 0.083 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.834816 | 0.078 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.835096 | 0.078 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.836897 | 0.077 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.840440 | 0.075 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.842183 | 0.075 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.843907 | 0.074 |
| R-HSA-9609507 | Protein localization | 0.845612 | 0.073 |
| R-HSA-162587 | HIV Life Cycle | 0.852249 | 0.069 |
| R-HSA-9711097 | Cellular response to starvation | 0.853864 | 0.069 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.863189 | 0.064 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.863189 | 0.064 |
| R-HSA-72766 | Translation | 0.869464 | 0.061 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.874708 | 0.058 |
| R-HSA-2262752 | Cellular responses to stress | 0.882820 | 0.054 |
| R-HSA-168255 | Influenza Infection | 0.885263 | 0.053 |
| R-HSA-2559583 | Cellular Senescence | 0.886518 | 0.052 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.888910 | 0.051 |
| R-HSA-8957322 | Metabolism of steroids | 0.889877 | 0.051 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.890204 | 0.051 |
| R-HSA-6798695 | Neutrophil degranulation | 0.894384 | 0.048 |
| R-HSA-1474244 | Extracellular matrix organization | 0.896435 | 0.047 |
| R-HSA-1280218 | Adaptive Immune System | 0.899249 | 0.046 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.899460 | 0.046 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.910932 | 0.041 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.911674 | 0.040 |
| R-HSA-9748784 | Drug ADME | 0.926154 | 0.033 |
| R-HSA-162906 | HIV Infection | 0.933135 | 0.030 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.933869 | 0.030 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.935313 | 0.029 |
| R-HSA-913531 | Interferon Signaling | 0.935502 | 0.029 |
| R-HSA-157118 | Signaling by NOTCH | 0.942076 | 0.026 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.942733 | 0.026 |
| R-HSA-5688426 | Deubiquitination | 0.950924 | 0.022 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.954874 | 0.020 |
| R-HSA-597592 | Post-translational protein modification | 0.959473 | 0.018 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.960228 | 0.018 |
| R-HSA-446728 | Cell junction organization | 0.961951 | 0.017 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.968482 | 0.014 |
| R-HSA-195721 | Signaling by WNT | 0.969513 | 0.013 |
| R-HSA-9824446 | Viral Infection Pathways | 0.969516 | 0.013 |
| R-HSA-1500931 | Cell-Cell communication | 0.975031 | 0.011 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.981085 | 0.008 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.981295 | 0.008 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.985356 | 0.006 |
| R-HSA-9679506 | SARS-CoV Infections | 0.987229 | 0.006 |
| R-HSA-392499 | Metabolism of proteins | 0.992615 | 0.003 |
| R-HSA-449147 | Signaling by Interleukins | 0.993573 | 0.003 |
| R-HSA-162582 | Signal Transduction | 0.997293 | 0.001 |
| R-HSA-168249 | Innate Immune System | 0.997398 | 0.001 |
| R-HSA-1643685 | Disease | 0.997777 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 0.997824 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 0.998568 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 0.998957 | 0.000 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.999114 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999163 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999392 | 0.000 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.999579 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999588 | 0.000 |
| R-HSA-168256 | Immune System | 0.999701 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK3 |
0.830 | 0.761 | 1 | 0.848 |
KIS |
0.827 | 0.729 | 1 | 0.745 |
CDK1 |
0.824 | 0.802 | 1 | 0.800 |
P38G |
0.822 | 0.823 | 1 | 0.865 |
JNK2 |
0.818 | 0.830 | 1 | 0.821 |
CDK18 |
0.816 | 0.773 | 1 | 0.823 |
HIPK2 |
0.816 | 0.718 | 1 | 0.803 |
CDK17 |
0.816 | 0.793 | 1 | 0.855 |
CDK19 |
0.815 | 0.758 | 1 | 0.810 |
CDK8 |
0.813 | 0.766 | 1 | 0.772 |
P38D |
0.813 | 0.797 | 1 | 0.866 |
CLK3 |
0.810 | 0.535 | 1 | 0.458 |
JNK3 |
0.809 | 0.820 | 1 | 0.791 |
CDK5 |
0.808 | 0.752 | 1 | 0.744 |
CDK16 |
0.807 | 0.758 | 1 | 0.841 |
ERK1 |
0.805 | 0.767 | 1 | 0.803 |
P38B |
0.804 | 0.768 | 1 | 0.786 |
CDK13 |
0.803 | 0.755 | 1 | 0.797 |
DYRK4 |
0.803 | 0.719 | 1 | 0.814 |
DYRK2 |
0.801 | 0.697 | 1 | 0.712 |
CDK7 |
0.801 | 0.734 | 1 | 0.774 |
CDK12 |
0.799 | 0.751 | 1 | 0.818 |
P38A |
0.793 | 0.739 | 1 | 0.712 |
CDK9 |
0.793 | 0.738 | 1 | 0.790 |
CDK2 |
0.792 | 0.652 | 1 | 0.669 |
JNK1 |
0.792 | 0.737 | 1 | 0.822 |
DYRK1B |
0.792 | 0.681 | 1 | 0.767 |
CDK10 |
0.791 | 0.693 | 1 | 0.797 |
HIPK1 |
0.791 | 0.639 | 1 | 0.692 |
CDK14 |
0.789 | 0.728 | 1 | 0.780 |
CLK2 |
0.789 | 0.413 | -3 | 0.726 |
SRPK1 |
0.788 | 0.329 | -3 | 0.715 |
ERK2 |
0.787 | 0.755 | 1 | 0.746 |
CDK6 |
0.786 | 0.725 | 1 | 0.801 |
HIPK4 |
0.785 | 0.436 | 1 | 0.486 |
CDK4 |
0.783 | 0.736 | 1 | 0.827 |
CLK1 |
0.782 | 0.419 | -3 | 0.724 |
NLK |
0.781 | 0.646 | 1 | 0.494 |
DYRK1A |
0.777 | 0.555 | 1 | 0.671 |
SRPK2 |
0.777 | 0.263 | -3 | 0.647 |
HIPK3 |
0.776 | 0.610 | 1 | 0.663 |
CLK4 |
0.775 | 0.373 | -3 | 0.743 |
ERK5 |
0.772 | 0.350 | 1 | 0.408 |
COT |
0.771 | 0.010 | 2 | 0.814 |
MTOR |
0.770 | 0.219 | 1 | 0.285 |
DYRK3 |
0.767 | 0.490 | 1 | 0.654 |
SRPK3 |
0.761 | 0.217 | -3 | 0.691 |
PRP4 |
0.759 | 0.426 | -3 | 0.711 |
ICK |
0.759 | 0.306 | -3 | 0.794 |
MAK |
0.758 | 0.441 | -2 | 0.716 |
MOS |
0.757 | 0.003 | 1 | 0.155 |
CDKL1 |
0.757 | 0.122 | -3 | 0.766 |
CDKL5 |
0.756 | 0.130 | -3 | 0.757 |
DSTYK |
0.754 | -0.056 | 2 | 0.840 |
CDC7 |
0.754 | -0.100 | 1 | 0.115 |
FAM20C |
0.754 | 0.138 | 2 | 0.762 |
PRPK |
0.753 | -0.049 | -1 | 0.838 |
IKKB |
0.752 | -0.109 | -2 | 0.729 |
TBK1 |
0.752 | -0.136 | 1 | 0.084 |
GRK7 |
0.751 | 0.071 | 1 | 0.130 |
GRK1 |
0.751 | 0.018 | -2 | 0.772 |
MST4 |
0.750 | -0.014 | 2 | 0.788 |
PIM3 |
0.750 | -0.031 | -3 | 0.797 |
ERK7 |
0.749 | 0.255 | 2 | 0.521 |
BMPR1B |
0.749 | 0.025 | 1 | 0.090 |
IKKE |
0.748 | -0.143 | 1 | 0.084 |
CAMK2G |
0.748 | -0.035 | 2 | 0.760 |
GCN2 |
0.748 | -0.156 | 2 | 0.711 |
CHAK2 |
0.748 | -0.010 | -1 | 0.877 |
IKKA |
0.748 | -0.017 | -2 | 0.722 |
ATR |
0.747 | -0.054 | 1 | 0.148 |
NDR2 |
0.747 | -0.038 | -3 | 0.798 |
PRKD1 |
0.746 | -0.019 | -3 | 0.776 |
BMPR2 |
0.746 | -0.101 | -2 | 0.869 |
PIM1 |
0.746 | 0.031 | -3 | 0.751 |
CAMK1B |
0.745 | -0.042 | -3 | 0.830 |
RAF1 |
0.745 | -0.176 | 1 | 0.099 |
NEK6 |
0.745 | -0.071 | -2 | 0.850 |
PKN3 |
0.745 | -0.042 | -3 | 0.792 |
MOK |
0.744 | 0.399 | 1 | 0.574 |
PDHK4 |
0.744 | -0.160 | 1 | 0.163 |
PRKD2 |
0.743 | -0.004 | -3 | 0.734 |
WNK1 |
0.743 | -0.072 | -2 | 0.872 |
RSK2 |
0.743 | -0.017 | -3 | 0.743 |
ULK2 |
0.742 | -0.177 | 2 | 0.705 |
SKMLCK |
0.741 | -0.040 | -2 | 0.850 |
NUAK2 |
0.740 | -0.014 | -3 | 0.810 |
ATM |
0.740 | -0.034 | 1 | 0.119 |
NIK |
0.740 | -0.071 | -3 | 0.841 |
TGFBR1 |
0.740 | 0.009 | -2 | 0.812 |
PKCD |
0.740 | -0.024 | 2 | 0.717 |
GRK5 |
0.739 | -0.121 | -3 | 0.822 |
NDR1 |
0.738 | -0.069 | -3 | 0.796 |
TGFBR2 |
0.738 | -0.089 | -2 | 0.796 |
MLK1 |
0.738 | -0.123 | 2 | 0.747 |
GRK6 |
0.738 | -0.069 | 1 | 0.096 |
NEK7 |
0.737 | -0.160 | -3 | 0.782 |
CAMLCK |
0.737 | -0.042 | -2 | 0.824 |
PDHK1 |
0.737 | -0.205 | 1 | 0.144 |
DNAPK |
0.737 | -0.016 | 1 | 0.146 |
MLK3 |
0.737 | -0.037 | 2 | 0.680 |
RSK3 |
0.736 | -0.042 | -3 | 0.744 |
MAPKAPK2 |
0.736 | -0.029 | -3 | 0.695 |
PKN2 |
0.735 | -0.083 | -3 | 0.796 |
ALK4 |
0.735 | -0.020 | -2 | 0.836 |
P90RSK |
0.735 | -0.035 | -3 | 0.743 |
ULK1 |
0.735 | -0.153 | -3 | 0.770 |
P70S6KB |
0.734 | -0.031 | -3 | 0.765 |
AURC |
0.734 | -0.013 | -2 | 0.630 |
LATS1 |
0.733 | 0.018 | -3 | 0.811 |
GSK3A |
0.733 | 0.185 | 4 | 0.423 |
HUNK |
0.733 | -0.151 | 2 | 0.734 |
CAMK2D |
0.732 | -0.094 | -3 | 0.792 |
MARK4 |
0.732 | -0.088 | 4 | 0.776 |
CAMK2B |
0.732 | -0.022 | 2 | 0.761 |
ALK2 |
0.732 | -0.001 | -2 | 0.811 |
MAPKAPK3 |
0.731 | -0.080 | -3 | 0.736 |
BCKDK |
0.731 | -0.158 | -1 | 0.768 |
PKR |
0.731 | -0.051 | 1 | 0.112 |
LATS2 |
0.731 | -0.065 | -5 | 0.643 |
BMPR1A |
0.731 | 0.011 | 1 | 0.083 |
GRK4 |
0.731 | -0.109 | -2 | 0.809 |
PKACG |
0.731 | -0.050 | -2 | 0.723 |
DAPK2 |
0.731 | -0.088 | -3 | 0.828 |
CAMK2A |
0.730 | -0.019 | 2 | 0.747 |
PINK1 |
0.729 | 0.160 | 1 | 0.310 |
RIPK3 |
0.729 | -0.189 | 3 | 0.626 |
ACVR2B |
0.729 | -0.042 | -2 | 0.806 |
PKCB |
0.729 | -0.035 | 2 | 0.672 |
AMPKA1 |
0.729 | -0.102 | -3 | 0.816 |
RSK4 |
0.729 | -0.009 | -3 | 0.712 |
ACVR2A |
0.729 | -0.043 | -2 | 0.793 |
IRE1 |
0.729 | -0.119 | 1 | 0.091 |
PRKX |
0.728 | 0.029 | -3 | 0.659 |
PAK1 |
0.727 | -0.064 | -2 | 0.752 |
NEK9 |
0.727 | -0.193 | 2 | 0.760 |
PRKD3 |
0.727 | -0.032 | -3 | 0.717 |
WNK3 |
0.727 | -0.222 | 1 | 0.096 |
PKCA |
0.727 | -0.043 | 2 | 0.666 |
CK2A2 |
0.727 | 0.017 | 1 | 0.077 |
PKACB |
0.727 | -0.003 | -2 | 0.651 |
PLK3 |
0.727 | -0.036 | 2 | 0.702 |
DLK |
0.726 | -0.200 | 1 | 0.108 |
MLK2 |
0.726 | -0.160 | 2 | 0.747 |
MNK2 |
0.726 | -0.053 | -2 | 0.770 |
TTBK2 |
0.726 | -0.175 | 2 | 0.630 |
PAK6 |
0.726 | -0.033 | -2 | 0.666 |
YSK4 |
0.726 | -0.141 | 1 | 0.087 |
TSSK2 |
0.726 | -0.101 | -5 | 0.719 |
NIM1 |
0.725 | -0.110 | 3 | 0.666 |
PKCG |
0.724 | -0.060 | 2 | 0.671 |
MLK4 |
0.724 | -0.074 | 2 | 0.655 |
TSSK1 |
0.724 | -0.082 | -3 | 0.835 |
ANKRD3 |
0.723 | -0.200 | 1 | 0.111 |
CHAK1 |
0.723 | -0.118 | 2 | 0.704 |
SMG1 |
0.723 | -0.082 | 1 | 0.135 |
AMPKA2 |
0.723 | -0.090 | -3 | 0.785 |
PLK1 |
0.723 | -0.120 | -2 | 0.781 |
MNK1 |
0.722 | -0.039 | -2 | 0.783 |
MASTL |
0.722 | -0.234 | -2 | 0.804 |
SGK3 |
0.722 | -0.030 | -3 | 0.731 |
AKT2 |
0.722 | 0.002 | -3 | 0.667 |
PAK3 |
0.722 | -0.104 | -2 | 0.754 |
IRE2 |
0.722 | -0.111 | 2 | 0.674 |
VRK2 |
0.722 | -0.051 | 1 | 0.199 |
PHKG1 |
0.722 | -0.100 | -3 | 0.783 |
TLK2 |
0.721 | -0.100 | 1 | 0.086 |
PKCZ |
0.721 | -0.068 | 2 | 0.710 |
PIM2 |
0.721 | -0.003 | -3 | 0.720 |
MPSK1 |
0.721 | 0.001 | 1 | 0.168 |
PKCH |
0.720 | -0.072 | 2 | 0.654 |
MSK2 |
0.720 | -0.067 | -3 | 0.705 |
NEK2 |
0.720 | -0.147 | 2 | 0.736 |
MEK1 |
0.720 | -0.146 | 2 | 0.751 |
TAO3 |
0.719 | -0.016 | 1 | 0.129 |
NUAK1 |
0.719 | -0.071 | -3 | 0.764 |
GRK2 |
0.719 | -0.068 | -2 | 0.692 |
RIPK1 |
0.719 | -0.245 | 1 | 0.082 |
PKG2 |
0.718 | -0.041 | -2 | 0.658 |
MST3 |
0.717 | -0.056 | 2 | 0.766 |
QSK |
0.717 | -0.081 | 4 | 0.749 |
MELK |
0.717 | -0.116 | -3 | 0.768 |
MSK1 |
0.716 | -0.050 | -3 | 0.713 |
SIK |
0.716 | -0.074 | -3 | 0.731 |
CAMK4 |
0.716 | -0.157 | -3 | 0.788 |
CK2A1 |
0.715 | -0.005 | 1 | 0.070 |
AURB |
0.715 | -0.055 | -2 | 0.621 |
BRSK1 |
0.715 | -0.087 | -3 | 0.759 |
DCAMKL1 |
0.715 | -0.056 | -3 | 0.758 |
DRAK1 |
0.714 | -0.141 | 1 | 0.070 |
CK1E |
0.714 | -0.031 | -3 | 0.528 |
BRAF |
0.714 | -0.104 | -4 | 0.754 |
PASK |
0.713 | -0.031 | -3 | 0.808 |
MARK3 |
0.713 | -0.074 | 4 | 0.700 |
QIK |
0.713 | -0.149 | -3 | 0.793 |
MEKK2 |
0.713 | -0.104 | 2 | 0.723 |
CHK1 |
0.713 | -0.085 | -3 | 0.809 |
MYLK4 |
0.713 | -0.073 | -2 | 0.747 |
GAK |
0.712 | -0.011 | 1 | 0.157 |
PERK |
0.712 | -0.152 | -2 | 0.832 |
ZAK |
0.712 | -0.155 | 1 | 0.093 |
PLK4 |
0.712 | -0.147 | 2 | 0.539 |
HRI |
0.711 | -0.169 | -2 | 0.846 |
PAK2 |
0.711 | -0.118 | -2 | 0.733 |
AURA |
0.711 | -0.057 | -2 | 0.579 |
MEKK3 |
0.711 | -0.162 | 1 | 0.102 |
MEKK1 |
0.711 | -0.161 | 1 | 0.108 |
MAPKAPK5 |
0.711 | -0.106 | -3 | 0.679 |
GSK3B |
0.710 | 0.025 | 4 | 0.411 |
TLK1 |
0.710 | -0.134 | -2 | 0.829 |
MARK2 |
0.710 | -0.087 | 4 | 0.665 |
TNIK |
0.710 | -0.011 | 3 | 0.811 |
AKT1 |
0.710 | -0.026 | -3 | 0.679 |
PLK2 |
0.709 | 0.037 | -3 | 0.878 |
DCAMKL2 |
0.709 | -0.066 | -3 | 0.782 |
WNK4 |
0.709 | -0.147 | -2 | 0.867 |
PKACA |
0.708 | -0.022 | -2 | 0.606 |
BRSK2 |
0.708 | -0.134 | -3 | 0.777 |
MEK5 |
0.708 | -0.196 | 2 | 0.738 |
PKCT |
0.708 | -0.082 | 2 | 0.660 |
PHKG2 |
0.708 | -0.100 | -3 | 0.771 |
TAO2 |
0.707 | -0.061 | 2 | 0.778 |
NEK5 |
0.707 | -0.167 | 1 | 0.090 |
IRAK4 |
0.707 | -0.155 | 1 | 0.075 |
CAMK1G |
0.707 | -0.093 | -3 | 0.728 |
PKCE |
0.706 | -0.020 | 2 | 0.661 |
GCK |
0.706 | -0.071 | 1 | 0.109 |
CK1D |
0.705 | -0.017 | -3 | 0.469 |
GRK3 |
0.705 | -0.070 | -2 | 0.650 |
PKCI |
0.705 | -0.060 | 2 | 0.678 |
MARK1 |
0.704 | -0.114 | 4 | 0.727 |
SGK1 |
0.703 | 0.016 | -3 | 0.589 |
HGK |
0.703 | -0.076 | 3 | 0.788 |
PAK5 |
0.702 | -0.073 | -2 | 0.603 |
PDK1 |
0.702 | -0.092 | 1 | 0.135 |
SMMLCK |
0.701 | -0.082 | -3 | 0.780 |
CK1G1 |
0.701 | -0.078 | -3 | 0.516 |
SSTK |
0.701 | -0.095 | 4 | 0.747 |
NEK11 |
0.700 | -0.173 | 1 | 0.121 |
MINK |
0.700 | -0.106 | 1 | 0.085 |
P70S6K |
0.700 | -0.073 | -3 | 0.680 |
LKB1 |
0.700 | -0.099 | -3 | 0.774 |
EEF2K |
0.700 | -0.071 | 3 | 0.775 |
SNRK |
0.700 | -0.209 | 2 | 0.592 |
LOK |
0.700 | -0.074 | -2 | 0.763 |
AKT3 |
0.700 | -0.011 | -3 | 0.600 |
NEK8 |
0.699 | -0.173 | 2 | 0.742 |
SLK |
0.699 | -0.046 | -2 | 0.710 |
MST2 |
0.699 | -0.119 | 1 | 0.095 |
SBK |
0.699 | 0.079 | -3 | 0.553 |
HPK1 |
0.699 | -0.092 | 1 | 0.110 |
KHS1 |
0.698 | -0.060 | 1 | 0.104 |
CK1A2 |
0.698 | -0.045 | -3 | 0.472 |
KHS2 |
0.698 | -0.034 | 1 | 0.114 |
CAMKK1 |
0.698 | -0.188 | -2 | 0.730 |
PAK4 |
0.697 | -0.068 | -2 | 0.602 |
BUB1 |
0.697 | -0.022 | -5 | 0.663 |
LRRK2 |
0.697 | -0.058 | 2 | 0.770 |
PKN1 |
0.697 | -0.070 | -3 | 0.696 |
TTBK1 |
0.697 | -0.183 | 2 | 0.556 |
MAP3K15 |
0.696 | -0.139 | 1 | 0.107 |
CAMK1D |
0.696 | -0.067 | -3 | 0.665 |
HASPIN |
0.696 | 0.002 | -1 | 0.698 |
PBK |
0.695 | -0.057 | 1 | 0.144 |
MEKK6 |
0.694 | -0.155 | 1 | 0.107 |
TAK1 |
0.694 | -0.167 | 1 | 0.086 |
MRCKB |
0.694 | -0.033 | -3 | 0.709 |
ROCK2 |
0.693 | -0.034 | -3 | 0.754 |
DAPK3 |
0.693 | -0.073 | -3 | 0.765 |
MST1 |
0.692 | -0.132 | 1 | 0.084 |
NEK4 |
0.692 | -0.207 | 1 | 0.081 |
CAMKK2 |
0.692 | -0.182 | -2 | 0.731 |
MRCKA |
0.691 | -0.039 | -3 | 0.724 |
PDHK3_TYR |
0.691 | 0.124 | 4 | 0.880 |
YSK1 |
0.689 | -0.126 | 2 | 0.736 |
CHK2 |
0.688 | -0.056 | -3 | 0.617 |
OSR1 |
0.688 | -0.055 | 2 | 0.713 |
BIKE |
0.688 | -0.034 | 1 | 0.158 |
NEK1 |
0.687 | -0.205 | 1 | 0.075 |
IRAK1 |
0.686 | -0.250 | -1 | 0.738 |
VRK1 |
0.686 | -0.208 | 2 | 0.769 |
DAPK1 |
0.686 | -0.079 | -3 | 0.748 |
AAK1 |
0.685 | -0.001 | 1 | 0.172 |
STK33 |
0.685 | -0.141 | 2 | 0.540 |
DMPK1 |
0.684 | -0.011 | -3 | 0.731 |
ALPHAK3 |
0.684 | -0.028 | -1 | 0.759 |
TESK1_TYR |
0.684 | 0.017 | 3 | 0.792 |
CAMK1A |
0.681 | -0.073 | -3 | 0.628 |
PKMYT1_TYR |
0.681 | 0.062 | 3 | 0.742 |
MAP2K6_TYR |
0.680 | 0.042 | -1 | 0.851 |
TAO1 |
0.680 | -0.085 | 1 | 0.102 |
PDHK4_TYR |
0.680 | 0.028 | 2 | 0.800 |
MAP2K4_TYR |
0.680 | -0.006 | -1 | 0.848 |
TTK |
0.679 | -0.076 | -2 | 0.803 |
MEK2 |
0.679 | -0.225 | 2 | 0.718 |
LIMK2_TYR |
0.679 | 0.056 | -3 | 0.836 |
BMPR2_TYR |
0.678 | 0.026 | -1 | 0.845 |
CRIK |
0.678 | -0.028 | -3 | 0.673 |
ROCK1 |
0.678 | -0.051 | -3 | 0.723 |
NEK3 |
0.678 | -0.174 | 1 | 0.108 |
MYO3A |
0.677 | -0.083 | 1 | 0.100 |
ASK1 |
0.677 | -0.138 | 1 | 0.108 |
PDHK1_TYR |
0.677 | -0.008 | -1 | 0.877 |
MYO3B |
0.677 | -0.091 | 2 | 0.749 |
PINK1_TYR |
0.676 | -0.081 | 1 | 0.151 |
RIPK2 |
0.676 | -0.257 | 1 | 0.079 |
MAP2K7_TYR |
0.676 | -0.103 | 2 | 0.783 |
PKG1 |
0.674 | -0.075 | -2 | 0.588 |
EPHA6 |
0.673 | -0.057 | -1 | 0.853 |
RET |
0.672 | -0.117 | 1 | 0.122 |
CSF1R |
0.669 | -0.062 | 3 | 0.673 |
LIMK1_TYR |
0.669 | -0.050 | 2 | 0.782 |
TXK |
0.668 | -0.045 | 1 | 0.084 |
ABL2 |
0.668 | -0.057 | -1 | 0.799 |
JAK2 |
0.668 | -0.130 | 1 | 0.134 |
YES1 |
0.667 | -0.045 | -1 | 0.837 |
YANK3 |
0.667 | -0.073 | 2 | 0.354 |
EPHB4 |
0.667 | -0.100 | -1 | 0.820 |
NEK10_TYR |
0.666 | -0.107 | 1 | 0.108 |
MST1R |
0.666 | -0.134 | 3 | 0.685 |
TYK2 |
0.665 | -0.205 | 1 | 0.111 |
FGFR2 |
0.663 | -0.025 | 3 | 0.664 |
ABL1 |
0.663 | -0.079 | -1 | 0.793 |
CK1A |
0.663 | -0.065 | -3 | 0.382 |
BLK |
0.662 | -0.038 | -1 | 0.831 |
JAK3 |
0.662 | -0.120 | 1 | 0.115 |
TYRO3 |
0.662 | -0.158 | 3 | 0.682 |
ROS1 |
0.662 | -0.155 | 3 | 0.644 |
LCK |
0.662 | -0.061 | -1 | 0.823 |
FGR |
0.660 | -0.144 | 1 | 0.087 |
STLK3 |
0.660 | -0.186 | 1 | 0.078 |
EPHA4 |
0.660 | -0.066 | 2 | 0.713 |
DDR1 |
0.660 | -0.136 | 4 | 0.793 |
JAK1 |
0.659 | -0.121 | 1 | 0.107 |
HCK |
0.659 | -0.110 | -1 | 0.816 |
TNNI3K_TYR |
0.659 | -0.075 | 1 | 0.138 |
FYN |
0.659 | -0.023 | -1 | 0.800 |
KIT |
0.659 | -0.097 | 3 | 0.672 |
FER |
0.658 | -0.140 | 1 | 0.101 |
INSRR |
0.658 | -0.104 | 3 | 0.615 |
FLT3 |
0.658 | -0.128 | 3 | 0.674 |
FGFR1 |
0.657 | -0.059 | 3 | 0.628 |
KDR |
0.656 | -0.096 | 3 | 0.637 |
SRMS |
0.655 | -0.135 | 1 | 0.077 |
EPHB2 |
0.655 | -0.115 | -1 | 0.800 |
EGFR |
0.654 | -0.055 | 1 | 0.078 |
TNK1 |
0.654 | -0.112 | 3 | 0.660 |
ITK |
0.654 | -0.135 | -1 | 0.776 |
FGFR3 |
0.653 | -0.038 | 3 | 0.639 |
TEK |
0.653 | -0.052 | 3 | 0.610 |
EPHB1 |
0.653 | -0.163 | 1 | 0.083 |
PDGFRB |
0.652 | -0.193 | 3 | 0.678 |
MET |
0.652 | -0.099 | 3 | 0.660 |
TNK2 |
0.652 | -0.156 | 3 | 0.625 |
EPHB3 |
0.652 | -0.149 | -1 | 0.808 |
WEE1_TYR |
0.651 | -0.086 | -1 | 0.731 |
MERTK |
0.651 | -0.133 | 3 | 0.651 |
ERBB2 |
0.649 | -0.131 | 1 | 0.097 |
FLT1 |
0.649 | -0.115 | -1 | 0.814 |
BMX |
0.649 | -0.110 | -1 | 0.702 |
TEC |
0.648 | -0.123 | -1 | 0.726 |
AXL |
0.648 | -0.173 | 3 | 0.647 |
EPHA7 |
0.647 | -0.119 | 2 | 0.710 |
FGFR4 |
0.647 | -0.049 | -1 | 0.752 |
FRK |
0.647 | -0.116 | -1 | 0.835 |
SRC |
0.646 | -0.073 | -1 | 0.803 |
BTK |
0.646 | -0.177 | -1 | 0.746 |
LYN |
0.645 | -0.100 | 3 | 0.583 |
MATK |
0.645 | -0.069 | -1 | 0.734 |
SYK |
0.644 | -0.041 | -1 | 0.760 |
DDR2 |
0.644 | -0.068 | 3 | 0.593 |
PDGFRA |
0.644 | -0.230 | 3 | 0.679 |
EPHA8 |
0.644 | -0.081 | -1 | 0.799 |
PTK2 |
0.643 | -0.037 | -1 | 0.766 |
CSK |
0.643 | -0.086 | 2 | 0.707 |
CK1G3 |
0.643 | -0.069 | -3 | 0.332 |
INSR |
0.642 | -0.145 | 3 | 0.593 |
ALK |
0.642 | -0.170 | 3 | 0.568 |
LTK |
0.642 | -0.165 | 3 | 0.596 |
NTRK3 |
0.642 | -0.134 | -1 | 0.741 |
NTRK1 |
0.642 | -0.190 | -1 | 0.784 |
FLT4 |
0.641 | -0.150 | 3 | 0.626 |
PTK2B |
0.641 | -0.108 | -1 | 0.769 |
EPHA3 |
0.641 | -0.144 | 2 | 0.681 |
EPHA5 |
0.640 | -0.109 | 2 | 0.700 |
PTK6 |
0.640 | -0.188 | -1 | 0.712 |
ERBB4 |
0.640 | -0.058 | 1 | 0.079 |
EPHA1 |
0.640 | -0.168 | 3 | 0.632 |
NTRK2 |
0.639 | -0.198 | 3 | 0.623 |
YANK2 |
0.635 | -0.087 | 2 | 0.375 |
MUSK |
0.633 | -0.146 | 1 | 0.062 |
EPHA2 |
0.631 | -0.111 | -1 | 0.757 |
IGF1R |
0.630 | -0.117 | 3 | 0.532 |
ZAP70 |
0.629 | -0.045 | -1 | 0.675 |
CK1G2 |
0.625 | -0.069 | -3 | 0.430 |
FES |
0.611 | -0.152 | -1 | 0.687 |