Motif 1093 (n=221)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | T2675 | ochoa | Snf2 related CREBBP activator protein | None |
| A0A1B0GVI7 | None | T351 | ochoa | Aryl hydrocarbon receptor | None |
| A6NJG2 | SOWAHD | T19 | ochoa | Ankyrin repeat domain-containing protein SOWAHD (Ankyrin repeat domain-containing protein 58) (Protein sosondowah homolog D) | None |
| A7KAX9 | ARHGAP32 | T2060 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| F8WAN1 | SPECC1L-ADORA2A | T52 | ochoa | SPECC1L-ADORA2A readthrough (NMD candidate) | None |
| J3QR06 | None | T119 | ochoa | Protein EVI2A | None |
| K7EQG2 | None | T110 | ochoa | Uncharacterized protein | None |
| O00161 | SNAP23 | T43 | ochoa | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23) | Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. |
| O00192 | ARVCF | T322 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00506 | STK25 | T166 | ochoa | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:18782753}. |
| O14640 | DVL1 | T674 | ochoa | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| O14744 | PRMT5 | T132 | psp | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805}. |
| O14983 | ATP2A1 | T357 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15061 | SYNM | T622 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15061 | SYNM | T635 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15105 | SMAD7 | T96 | psp | Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7) | Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access (PubMed:21791611). Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:11163210, ECO:0000269|PubMed:12023024, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:9892009}. |
| O15355 | PPM1G | T196 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15446 | POLR1G | T171 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O60356 | NUPR1 | T54 | ochoa | Nuclear protein 1 (Candidate of metastasis 1) (Protein p8) | Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}. |
| O60361 | NME2P1 | T79 | ochoa | Putative nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). {ECO:0000250}. |
| O60503 | ADCY9 | T662 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O75369 | FLNB | T1609 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75533 | SF3B1 | T285 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O75533 | SF3B1 | T296 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O76021 | RSL1D1 | T340 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O76061 | STC2 | T254 | ochoa | Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP) | Has an anti-hypocalcemic action on calcium and phosphate homeostasis. |
| P02671 | FGA | T522 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P06127 | CD5 | T436 | psp | T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5) | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (PubMed:1384049, PubMed:1385158). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (PubMed:23376399). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (PubMed:27499044). {ECO:0000250|UniProtKB:P13379, ECO:0000269|PubMed:1384049, ECO:0000269|PubMed:1385158, ECO:0000269|PubMed:23376399, ECO:0000269|PubMed:27499044}. |
| P06239 | LCK | T268 | ochoa | Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) | Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501, ECO:0000269|PubMed:38614099}. |
| P07948 | LYN | T270 | ochoa | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (PubMed:36932076). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:36122175, ECO:0000269|PubMed:36932076, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. |
| P08590 | MYL3 | T88 | ochoa | Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb) | Regulatory light chain of myosin. Does not bind calcium. |
| P08621 | SNRNP70 | T216 | ochoa | U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158). {ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:2467746, ECO:0000269|PubMed:25555158}.; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}.; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. {ECO:0000269|PubMed:2467746}. |
| P09884 | POLA1 | T174 | ochoa | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}. |
| P0DMV8 | HSPA1A | T66 | psp | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250|UniProtKB:P0DMW0, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
| P11021 | HSPA5 | T62 | psp | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P11137 | MAP2 | T733 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11216 | PYGB | T219 | ochoa | Glycogen phosphorylase, brain form (EC 2.4.1.1) | Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228). {ECO:0000269|PubMed:27402852, ECO:0000303|PubMed:3346228}. |
| P14923 | JUP | T78 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P15531 | NME1 | T94 | ochoa | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| P15924 | DSP | T184 | ochoa | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). {ECO:0000250|UniProtKB:F1LMV6}. |
| P16150 | SPN | T343 | ochoa | Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}. |
| P16615 | ATP2A2 | T357 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P17066 | HSPA6 | T68 | ochoa | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P18825 | ADRA2C | T334 | ochoa | Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. |
| P21980 | TGM2 | T386 | ochoa | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P22392 | NME2 | T94 | ochoa | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {ECO:0000250|UniProtKB:P36010, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}. |
| P22794 | EVI2A | T195 | ochoa | Protein EVI2A (Ecotropic viral integration site 2A protein homolog) (EVI-2A) | May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor. |
| P25398 | RPS12 | T24 | ochoa | Small ribosomal subunit protein eS12 (40S ribosomal protein S12) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Subunit of the 40S ribosomal complex (By similarity). {ECO:0000250|UniProtKB:P80455, ECO:0000269|PubMed:34516797}. |
| P35869 | AHR | T361 | ochoa | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P36897 | TGFBR1 | T204 | psp | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P37198 | NUP62 | T269 | psp | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P37231 | PPARG | T166 | psp | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) | Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity). {ECO:0000250|UniProtKB:P37238, ECO:0000269|PubMed:16150867, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:9065481}.; FUNCTION: (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. {ECO:0000269|PubMed:25504154}. |
| P40938 | RFC3 | T75 | ochoa | Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. {ECO:0000269|PubMed:9488738}. |
| P41091 | EIF2S3 | T21 | ochoa | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P43003 | SLC1A3 | T26 | psp | Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515, PubMed:7521911, PubMed:8123008). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P56564, ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}. |
| P48634 | PRRC2A | T1607 | ochoa | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | May play a role in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:14667819}. |
| P48741 | HSPA7 | T68 | ochoa | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| P49757 | NUMB | T436 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P49790 | NUP153 | T281 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | T1026 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50990 | CCT8 | T517 | psp | T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P52756 | RBM5 | T438 | ochoa | RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) | Component of the spliceosome A complex. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. {ECO:0000269|PubMed:10949932, ECO:0000269|PubMed:12207175, ECO:0000269|PubMed:12581154, ECO:0000269|PubMed:15192330, ECO:0000269|PubMed:16585163, ECO:0000269|PubMed:18840686, ECO:0000269|PubMed:18851835, ECO:0000269|PubMed:21256132}. |
| P54132 | BLM | T526 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54792 | DVL1P1 | T649 | ochoa | Putative segment polarity protein dishevelled homolog DVL1P1 (DSH homolog 1-like) (Segment polarity protein dishevelled homolog DVL-1-like) (Dishevelled-1-like) | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| P55011 | SLC12A2 | T203 | psp | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P55011 | SLC12A2 | T207 | psp | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1) | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}. |
| P56192 | MARS1 | T833 | ochoa | Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:11714285, ECO:0000269|PubMed:33909043}. |
| P56817 | BACE1 | T252 | psp | Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity). {ECO:0000250|UniProtKB:P56818, ECO:0000269|PubMed:10656250, ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:20354142}. |
| P60201 | PLP1 | T116 | ochoa | Myelin proteolipid protein (PLP) (Lipophilin) | This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. |
| P68104 | EEF1A1 | T239 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| Q00688 | FKBP3 | T151 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q04721 | NOTCH2 | T2295 | ochoa | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q07812 | BAX | T174 | psp | Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) | Plays a role in the mitochondrial apoptotic process (PubMed:10772918, PubMed:11060313, PubMed:16113678, PubMed:16199525, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:36361894, PubMed:8358790, PubMed:8521816). Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis (PubMed:10772918, PubMed:11060313, PubMed:16113678, PubMed:16199525, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816). Promotes activation of CASP3, and thereby apoptosis (PubMed:10772918, PubMed:11060313, PubMed:16113678, PubMed:16199525, PubMed:18948948, PubMed:21199865, PubMed:21458670, PubMed:25609812, PubMed:8358790, PubMed:8521816). {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:11060313, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:16199525, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:21458670, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:36361894, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}. |
| Q08357 | SLC20A2 | T346 | ochoa | Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2) | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250|UniProtKB:Q80UP8, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:22327515, ECO:0000269|PubMed:28722801, ECO:0000269|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:8302848}. |
| Q08AM6 | VAC14 | T499 | ochoa | Protein VAC14 homolog (Tax1-binding protein 2) | Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:33098764}. |
| Q13043 | STK4 | T175 | ochoa | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13043 | STK4 | T353 | psp | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q13188 | STK3 | T172 | ochoa | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:21723128, ECO:0000269|PubMed:23972470, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}. |
| Q13224 | GRIN2B | T888 | ochoa | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:24272827, PubMed:24863970, PubMed:26875626, PubMed:26919761, PubMed:27839871, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:28095420, PubMed:28126851, PubMed:38538865, PubMed:8768735). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:24272827, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q13555 | CAMK2G | T37 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q13561 | DCTN2 | T206 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| Q13627 | DYRK1A | T543 | ochoa | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:20981014, PubMed:21127067, PubMed:23665168, PubMed:30773093, PubMed:8769099). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}. |
| Q14315 | FLNC | T1464 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14574 | DSC3 | T788 | ochoa | Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). {ECO:0000250|UniProtKB:P55850, ECO:0000269|PubMed:19717567}. |
| Q14687 | GSE1 | T433 | ochoa | Genetic suppressor element 1 | None |
| Q14687 | GSE1 | T1008 | ochoa | Genetic suppressor element 1 | None |
| Q15056 | EIF4H | T43 | ochoa | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) | Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. {ECO:0000269|PubMed:10585411, ECO:0000269|PubMed:11418588}. |
| Q15075 | EEA1 | T1392 | psp | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
| Q15233 | NONO | T440 | ochoa | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | DNA- and RNA binding protein, involved in several nuclear processes (PubMed:11525732, PubMed:12403470, PubMed:26571461). Binds the conventional octamer sequence in double-stranded DNA (PubMed:11525732, PubMed:12403470, PubMed:26571461). Also binds single-stranded DNA and RNA at a site independent of the duplex site (PubMed:11525732, PubMed:12403470, PubMed:26571461). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (PubMed:11525732, PubMed:12403470, PubMed:26571461). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (PubMed:12403470). Together with PSPC1, required for the formation of nuclear paraspeckles (PubMed:22416126). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (PubMed:11525732). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (PubMed:10858305). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (PubMed:15590677). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (PubMed:15590677). NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (PubMed:11897684). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728, PubMed:30270045). Promotes activation of the cGAS-STING pathway in response to HIV-2 infection: acts by interacting with HIV-2 Capsid protein p24, thereby promoting detection of viral DNA by CGAS, leading to CGAS-mediated inmmune activation (PubMed:30270045). In contrast, the weak interaction with HIV-1 Capsid protein p24 does not allow activation of the cGAS-STING pathway (PubMed:30270045). {ECO:0000250|UniProtKB:Q99K48, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:12403470, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:30270045}. |
| Q15392 | DHCR24 | T110 | psp | Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) | Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:22178193, PubMed:25637936). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:21671375, ECO:0000269|PubMed:22010141, ECO:0000269|PubMed:22178193, ECO:0000269|PubMed:25637936}. |
| Q15596 | NCOA2 | T457 | ochoa | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q16539 | MAPK14 | T123 | psp | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:9430721, PubMed:9858528). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}. |
| Q27J81 | INF2 | T561 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2VIR3 | EIF2S3B | T21 | ochoa | Eukaryotic translation initiation factor 2 subunit 3B (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198}. |
| Q4KMQ1 | TPRN | T200 | ochoa | Taperin | Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (PubMed:23213405). Recruited to sites of DNA damage and may play a role in DNA damage repair (PubMed:23213405). {ECO:0000250|UniProtKB:A2AI08, ECO:0000269|PubMed:23213405}. |
| Q53HL2 | CDCA8 | T230 | psp | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}. |
| Q5JSZ5 | PRRC2B | T1463 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5M775 | SPECC1 | T844 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5T0Z8 | C6orf132 | T68 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T5X7 | BEND3 | T123 | ochoa | BEN domain-containing protein 3 | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). {ECO:0000250|UniProtKB:Q6PAL0, ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:26100909, ECO:0000269|PubMed:28977671}. |
| Q5T5Y3 | CAMSAP1 | T466 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5VTE0 | EEF1A1P5 | T239 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q5VY43 | PEAR1 | T927 | ochoa | Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) | Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}. |
| Q641Q2 | WASHC2A | T1023 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q69YQ0 | SPECC1L | T52 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6DN90 | IQSEC1 | T88 | ochoa | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250|UniProtKB:A0A0G2JUG7, ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294, ECO:0000305|PubMed:31607425}. |
| Q6GQQ9 | OTUD7B | T547 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6P2E9 | EDC4 | T816 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6ZRS2 | SRCAP | T2852 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q7Z417 | NUFIP2 | T220 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z6J0 | SH3RF1 | T567 | ochoa | E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) | Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination (PubMed:15659549, PubMed:20696164). Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis (PubMed:19710010). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}.; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. {ECO:0000269|PubMed:15659549}. |
| Q86UU1 | PHLDB1 | T643 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86W42 | THOC6 | T252 | ochoa | THO complex subunit 6 (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15998806, PubMed:17190602). Plays a role in apoptosis negative control involved in brain development (PubMed:15833825, PubMed:23621916). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:23621916, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q86YS7 | C2CD5 | T339 | ochoa | C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa) | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}. |
| Q8IUW5 | RELL1 | T182 | ochoa | RELT-like protein 1 | Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). {ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764}. |
| Q8IWZ3 | ANKHD1 | T1599 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8N196 | SIX5 | T275 | ochoa | Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) | Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). {ECO:0000250}. |
| Q8N196 | SIX5 | T276 | ochoa | Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) | Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). {ECO:0000250}. |
| Q8NC51 | SERBP1 | T61 | ochoa | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). {ECO:0000250|UniProtKB:Q9CY58, ECO:0000269|PubMed:11001948, ECO:0000269|PubMed:28695742, ECO:0000269|PubMed:36691768}. |
| Q8NCN4 | RNF169 | T554 | ochoa | E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169) | Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833, ECO:0000269|PubMed:30104380, ECO:0000269|PubMed:30773093}. |
| Q8TAD7 | OCC1 | T30 | ochoa | Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3) | None |
| Q8WUA4 | GTF3C2 | T21 | ochoa | General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta) | Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. |
| Q92614 | MYO18A | T1008 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92625 | ANKS1A | T585 | ochoa | Ankyrin repeat and SAM domain-containing protein 1A (Odin) | Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}. |
| Q92804 | TAF15 | T222 | ochoa | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016, ECO:0000269|PubMed:21256132}. |
| Q92847 | GHSR | T261 | psp | Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) | Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). {ECO:0000269|PubMed:10604470, ECO:0000269|PubMed:11322507}. |
| Q93084 | ATP2A3 | T357 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Q969Z4 | RELT | T223 | ochoa | Tumor necrosis factor receptor superfamily member 19L (Receptor expressed in lymphoid tissues) | May play a role in apoptosis (PubMed:19969290, PubMed:28688764). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Involved in dental enamel formation (PubMed:30506946). {ECO:0000269|PubMed:16530727, ECO:0000269|PubMed:19969290, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:30506946}. |
| Q96A00 | PPP1R14A | T38 | psp | Protein phosphatase 1 regulatory subunit 14A (17 kDa PKC-potentiated inhibitory protein of PP1) (Protein kinase C-potentiated inhibitor protein of 17 kDa) (CPI-17) | Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. |
| Q96M27 | PRRC1 | T233 | ochoa | Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1) | May act as a regulator of the protein kinase A (PKA) activity during embryonic development. {ECO:0000250|UniProtKB:Q5XJA3}. |
| Q9C0B5 | ZDHHC5 | T659 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C2 | TNKS1BP1 | T421 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0G0 | ZNF407 | T940 | ochoa | Zinc finger protein 407 | May be involved in transcriptional regulation. |
| Q9H2C2 | ARV1 | T22 | ochoa | Protein ARV1 (hARV1) | Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892). {ECO:0000269|PubMed:11063737, ECO:0000269|PubMed:12145310, ECO:0000269|PubMed:20663892}. |
| Q9H3U1 | UNC45A | T53 | ochoa | Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1) | Acts as a co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). {ECO:0000250, ECO:0000269|PubMed:12119110, ECO:0000269|PubMed:16478993, ECO:0000305}. |
| Q9H7Z6 | KAT8 | T392 | psp | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (Males-absent on the first protein homolog) (hMOF) (Protein acetyltransferase KAT8) (EC 2.3.1.-) (Protein propionyltransferase KAT8) (EC 2.3.1.-) | Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:20018852, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:31794431, PubMed:33837287). Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:12397079, PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:33657400, PubMed:33837287). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism (PubMed:27768893). Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (PubMed:17189187, PubMed:19854137, PubMed:37369679). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters (By similarity). Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120' (PubMed:17189187, PubMed:19854137). Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (PubMed:27292636). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA (By similarity). Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (PubMed:29321206). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:12397079, ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:27292636, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:29321206, ECO:0000269|PubMed:31794431, ECO:0000269|PubMed:33657400, ECO:0000269|PubMed:33837287, ECO:0000269|PubMed:37369679}. |
| Q9HCK8 | CHD8 | T537 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NR33 | POLE4 | T31 | ochoa | DNA polymerase epsilon subunit 4 (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity). {ECO:0000250|UniProtKB:P27344, ECO:0000269|PubMed:10801849}. |
| Q9NWV8 | BABAM1 | T65 | ochoa | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}. |
| Q9NWZ3 | IRAK4 | T209 | psp | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q9NZP8 | C1RL | T138 | ochoa | Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa) | Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. {ECO:0000269|PubMed:15358180, ECO:0000269|PubMed:15385675, ECO:0000269|PubMed:15527420}. |
| Q9P244 | LRFN1 | T658 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P289 | STK26 | T170 | ochoa | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:27807006, ECO:0000269|PubMed:29232556}. |
| Q9UBC2 | EPS15L1 | T674 | ochoa | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. |
| Q9UBU6 | FAM8A1 | T195 | ochoa | Protein FAM8A1 (Autosomal highly conserved protein) | Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD). {ECO:0000269|PubMed:28827405}. |
| Q9UHL0 | DDX25 | T239 | psp | ATP-dependent RNA helicase DDX25 (EC 3.6.4.13) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase) | ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10608860}. |
| Q9UJF2 | RASAL2 | T617 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UMN6 | KMT2B | T948 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UPQ9 | TNRC6B | T1444 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPQ9 | TNRC6B | T1464 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPU5 | USP24 | T2025 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UQP3 | TNN | T938 | ochoa | Tenascin-N (TN-N) (Tenascin-W) (TN-W) | Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022). {ECO:0000250|UniProtKB:Q80YX1, ECO:0000250|UniProtKB:Q80Z71, ECO:0000269|PubMed:17909022, ECO:0000269|PubMed:19884327}. |
| Q9Y289 | SLC5A6 | T286 | psp | Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6) | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed:21570947, PubMed:22015582, PubMed:25809983, PubMed:25971966, PubMed:27904971, PubMed:28052864, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983). {ECO:0000250|UniProtKB:Q5U4D8, ECO:0000269|PubMed:10329687, ECO:0000269|PubMed:15561972, ECO:0000269|PubMed:19211916, ECO:0000269|PubMed:20980265, ECO:0000269|PubMed:21570947, ECO:0000269|PubMed:22015582, ECO:0000269|PubMed:25809983, ECO:0000269|PubMed:25971966, ECO:0000269|PubMed:27904971, ECO:0000269|PubMed:28052864, ECO:0000269|PubMed:31754459}. |
| Q9Y2L1 | DIS3 | T428 | ochoa | Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. {ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20531386}. |
| Q9Y6E0 | STK24 | T182 | ochoa | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}. |
| P27695 | APEX1 | T19 | Sugiyama | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] | Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (PubMed:11118054, PubMed:11452037, PubMed:15831793, PubMed:18439621, PubMed:18579163, PubMed:21762700, PubMed:24079850, PubMed:8355688, PubMed:9108029, PubMed:9560228). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (PubMed:15380100, PubMed:16617147, PubMed:18439621, PubMed:19123919, PubMed:19188445, PubMed:19934257, PubMed:20699270, PubMed:21762700, PubMed:24079850, PubMed:8932375, PubMed:8995436, PubMed:9804799). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (PubMed:11832948, PubMed:1719477). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (PubMed:15831793, PubMed:7516064). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (PubMed:19188445, PubMed:19401441, PubMed:21762700). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (PubMed:9207062). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (PubMed:10023679, PubMed:11118054, PubMed:11452037, PubMed:18579163, PubMed:8355688, PubMed:9108029). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (PubMed:11809897, PubMed:14633989, PubMed:8621488). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (PubMed:18809583). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (PubMed:18179823). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (PubMed:19188445, PubMed:19401441, PubMed:20699270). {ECO:0000250|UniProtKB:P28352, ECO:0000269|PubMed:10023679, ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:11452037, ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:11832948, ECO:0000269|PubMed:12524539, ECO:0000269|PubMed:14633989, ECO:0000269|PubMed:15380100, ECO:0000269|PubMed:15831793, ECO:0000269|PubMed:16617147, ECO:0000269|PubMed:1719477, ECO:0000269|PubMed:18179823, ECO:0000269|PubMed:18439621, ECO:0000269|PubMed:18579163, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19123919, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:19401441, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20699270, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21762700, ECO:0000269|PubMed:24079850, ECO:0000269|PubMed:7516064, ECO:0000269|PubMed:8355688, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:8932375, ECO:0000269|PubMed:8995436, ECO:0000269|PubMed:9108029, ECO:0000269|PubMed:9207062, ECO:0000269|PubMed:9560228, ECO:0000269|PubMed:9804799}. |
| Q15084 | PDIA6 | T166 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| P11142 | HSPA8 | T66 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P38646 | HSPA9 | T116 | Sugiyama | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P62917 | RPL8 | T135 | Sugiyama | Large ribosomal subunit protein uL2 (60S ribosomal protein L8) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q6UXH1 | CRELD2 | T300 | Sugiyama | Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2) | Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698). {ECO:0000250|UniProtKB:Q9CYA0, ECO:0000269|PubMed:16238698}. |
| Q96G46 | DUS3L | T99 | Sugiyama | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) | Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860). {ECO:0000269|PubMed:34556860}. |
| P06733 | ENO1 | T55 | Sugiyama | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P18621 | RPL17 | T79 | Sugiyama | Large ribosomal subunit protein uL22 (60S ribosomal protein L17) (60S ribosomal protein L23) (PD-1) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P23526 | AHCY | T185 | Sugiyama | Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) | Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity). {ECO:0000250|UniProtKB:P50247, ECO:0000269|PubMed:10933798}. |
| P30040 | ERP29 | T43 | Sugiyama | Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31) | Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER. |
| P62424 | RPL7A | T142 | Sugiyama | Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (PLA-X polypeptide) (Surfeit locus protein 3) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q01518 | CAP1 | T165 | Sugiyama | Adenylyl cyclase-associated protein 1 (CAP 1) | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. |
| Q9Y3Y2 | CHTOP | T212 | EPSD|PSP | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}. |
| O15111 | CHUK | T392 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:18626576, PubMed:35952808, PubMed:9244310, PubMed:9252186, PubMed:9346484). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:18626576, PubMed:9244310, PubMed:9252186, PubMed:9346484). Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937). In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Also participates in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128). Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342). Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973). {ECO:0000250|UniProtKB:Q60680, ECO:0000269|PubMed:12789342, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17434128, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20501937, ECO:0000269|PubMed:21765415, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35952808, ECO:0000269|PubMed:9244310, ECO:0000269|PubMed:9252186, ECO:0000269|PubMed:9346484, ECO:0000303|PubMed:18626576}. |
| P26639 | TARS1 | T56 | Sugiyama | Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1) | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250|UniProtKB:Q9D0R2, ECO:0000269|PubMed:25824639, ECO:0000269|PubMed:31374204}. |
| P08865 | RPSA | T97 | Sugiyama | Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.; FUNCTION: (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; FUNCTION: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.; FUNCTION: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.; FUNCTION: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}. |
| P10809 | HSPD1 | T455 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| P11142 | HSPA8 | T38 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P34931 | HSPA1L | T40 | Sugiyama | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P54652 | HSPA2 | T39 | Sugiyama | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| O95757 | HSPA4L | T35 | Sugiyama | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) | Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}. |
| P17066 | HSPA6 | T40 | Sugiyama | Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303|PubMed:26865365}. |
| P48741 | HSPA7 | T40 | Sugiyama | Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7) | None |
| O00468 | AGRN | T654 | Sugiyama | Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] | [Isoform 1]: Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.; FUNCTION: [Isoform 2]: Transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.; FUNCTION: Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.; FUNCTION: Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.; FUNCTION: [Agrin N-terminal 110 kDa subunit]: Is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:19631309, ECO:0000269|PubMed:21969364}.; FUNCTION: [Agrin C-terminal 22 kDa fragment]: This released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia. |
| P38646 | HSPA9 | T111 | Sugiyama | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| O75676 | RPS6KA4 | T656 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| Q9ULX6 | AKAP8L | T267 | Sugiyama | A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95) | Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:12538639, ECO:0000269|PubMed:16980585, ECO:0000305|PubMed:10761695}.; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. {ECO:0000269|PubMed:11884601}.; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. {ECO:0000269|PubMed:11402034}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. {ECO:0000269|PubMed:25034436}. |
| Q92598 | HSPH1 | T63 | Sugiyama | Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250|UniProtKB:Q60446, ECO:0000250|UniProtKB:Q61699, ECO:0000269|PubMed:24318877}. |
| P10809 | HSPD1 | T478 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| Q13283 | G3BP1 | T71 | Sugiyama | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q96C19 | EFHD2 | T84 | Sugiyama | EF-hand domain-containing protein D2 (Swiprosin-1) | May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
| O60701 | UGDH | T461 | EPSD|PSP | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| Q9BX68 | HINT2 | T47 | Sugiyama | Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718, ECO:0000269|PubMed:31990367}. |
| Q86VB7 | CD163 | T1072 | EPSD | Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] | Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.; FUNCTION: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. |
| Q9UHD1 | CHORDC1 | T25 | Sugiyama | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) | Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269|PubMed:20230755, ECO:0000269|PubMed:32053105}. |
| P24752 | ACAT1 | T185 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
| Q68BL8 | OLFML2B | T506 | Sugiyama | Olfactomedin-like protein 2B (Photomedin-2) | None |
| P34932 | HSPA4 | T35 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| P51813 | BMX | T331 | Sugiyama | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269|PubMed:10688651, ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:12370298, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:15788485, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:9520419}. |
| P09661 | SNRPA1 | T213 | Sugiyama | U2 small nuclear ribonucleoprotein A' (U2 snRNP A') | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:27035939, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:9716128}. |
| P11413 | G6PD | T236 | SIGNOR | Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}. |
| Q06187 | BTK | T316 | Sugiyama | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:19290921). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (PubMed:19290921). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (PubMed:11606584). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (PubMed:11606584). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (PubMed:16517732, PubMed:17932028). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:16517732). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (PubMed:16517732). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (PubMed:16517732, PubMed:17932028). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (PubMed:16415872). BTK also plays a critical role in transcription regulation (PubMed:19290921). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:19290921). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (PubMed:19290921). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:9012831). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:9012831). ARID3A and NFAT are other transcriptional target of BTK (PubMed:16738337). BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:16738337). There is however no evidence that BTK itself binds directly to DNA (PubMed:16738337). BTK has a dual role in the regulation of apoptosis (PubMed:9751072). Plays a role in STING1-mediated induction of type I interferon (IFN) response by phosphorylating DDX41 (PubMed:25704810). {ECO:0000269|PubMed:11606584, ECO:0000269|PubMed:16415872, ECO:0000269|PubMed:16517732, ECO:0000269|PubMed:16738337, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:9012831, ECO:0000303|PubMed:19290921, ECO:0000303|PubMed:9751072}. |
| Q04721 | NOTCH2 | T132 | Sugiyama | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737). {ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985, ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737, ECO:0000269|PubMed:29149593}. |
| Q08881 | ITK | T274 | Sugiyama | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). {ECO:0000250|UniProtKB:Q03526, ECO:0000269|PubMed:12186560, ECO:0000269|PubMed:12682224, ECO:0000269|PubMed:21725281}. |
| O15212 | PFDN6 | T75 | Sugiyama | Prefoldin subunit 6 (Protein Ke2) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q13043 | STK4 | T122 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| P34897 | SHMT2 | T432 | Sugiyama | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:25619277, PubMed:29364879, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29364879, PubMed:29452640). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985). {ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:21876188, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25619277, ECO:0000269|PubMed:29364879, ECO:0000269|PubMed:29452640, ECO:0000269|PubMed:33015733}. |
| P10809 | HSPD1 | T320 | Sugiyama | 60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) | Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000305|PubMed:25918392}. |
| Q13976 | PRKG1 | T269 | Sugiyama | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| P30405 | PPIF | T74 | Sugiyama | Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:Q99KR7, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}. |
| O75369 | FLNB | T1444 | Sugiyama | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| Q86UE8 | TLK2 | T313 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86UE8 | TLK2 | T483 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q8N568 | DCLK2 | T254 | Sugiyama | Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}. |
| Q92974 | ARHGEF2 | T802 | Sugiyama | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40) | Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity). {ECO:0000250|UniProtKB:Q60875, ECO:0000250|UniProtKB:Q865S3, ECO:0000269|PubMed:19043560, ECO:0000269|PubMed:21887730, ECO:0000269|PubMed:28453519, ECO:0000269|PubMed:9857026}. |
| Q9BQ69 | MACROD1 | T196 | Sugiyama | ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-) | Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104). {ECO:0000269|PubMed:17893710, ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}. |
| Q96QR8 | PURB | T31 | Sugiyama | Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) | Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (By similarity). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (PubMed:1448097). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250|UniProtKB:O35295, ECO:0000250|UniProtKB:Q68A21, ECO:0000269|PubMed:1448097}. |
| P41091 | EIF2S3 | T120 | Sugiyama | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| Q96CP2 | FLYWCH2 | T83 | Sugiyama | FLYWCH family member 2 | None |
| Q99759 | MAP3K3 | T462 | Sugiyama | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:33729480, ECO:0000269|PubMed:33891857, ECO:0000269|PubMed:9006902}. |
| Q9BZL6 | PRKD2 | T502 | Sugiyama | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250|UniProtKB:Q8BZ03, ECO:0000269|PubMed:14743217, ECO:0000269|PubMed:15604256, ECO:0000269|PubMed:16928771, ECO:0000269|PubMed:17077180, ECO:0000269|PubMed:17951978, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:18262756, ECO:0000269|PubMed:19001381, ECO:0000269|PubMed:19192391, ECO:0000269|PubMed:23503467, ECO:0000269|PubMed:28428613}. |
| Q9NYY3 | PLK2 | T103 | Sugiyama | Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase) | Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CPAP, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CPAP and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:20531387}. |
| P62937 | PPIA | T32 | Sugiyama | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:22347431, PubMed:30328013). {ECO:0000250|UniProtKB:P17742, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:15130913, ECO:0000269|PubMed:19207730, ECO:0000269|PubMed:2001362, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:21245143, ECO:0000269|PubMed:21593166, ECO:0000269|PubMed:22347431, ECO:0000269|PubMed:23180369, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:30328013, ECO:0000269|PubMed:31063815}.; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (PubMed:15688292). {ECO:0000269|PubMed:15688292}.; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. {ECO:0000269|PubMed:21593166}. |
| Q96PV0 | SYNGAP1 | T1077 | SIGNOR|iPTMNet | Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). {ECO:0000250}. |
| Q8N3A8 | PARP8 | T355 | Sugiyama | Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.110223e-16 | 15.955 |
| R-HSA-3371556 | Cellular response to heat stress | 1.110223e-16 | 15.955 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.443290e-15 | 14.841 |
| R-HSA-3371568 | Attenuation phase | 1.110223e-15 | 14.955 |
| R-HSA-2262752 | Cellular responses to stress | 1.849743e-12 | 11.733 |
| R-HSA-3371511 | HSF1 activation | 3.918199e-12 | 11.407 |
| R-HSA-8953897 | Cellular responses to stimuli | 8.616774e-12 | 11.065 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 6.331602e-05 | 4.198 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.621511e-04 | 3.790 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.483975e-04 | 3.829 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.836691e-04 | 3.547 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 4.157655e-04 | 3.381 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 4.872890e-04 | 3.312 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.750034e-04 | 3.323 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.750034e-04 | 3.323 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 7.953125e-04 | 3.099 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 7.953125e-04 | 3.099 |
| R-HSA-156902 | Peptide chain elongation | 6.750487e-04 | 3.171 |
| R-HSA-168255 | Influenza Infection | 8.333472e-04 | 3.079 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 8.407580e-04 | 3.075 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.032287e-03 | 2.986 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.227809e-03 | 2.911 |
| R-HSA-69109 | Leading Strand Synthesis | 1.828483e-03 | 2.738 |
| R-HSA-69091 | Polymerase switching | 1.828483e-03 | 2.738 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 1.404955e-03 | 2.852 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.780265e-03 | 2.750 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.523025e-03 | 2.817 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.707979e-03 | 2.768 |
| R-HSA-9833482 | PKR-mediated signaling | 2.151199e-03 | 2.667 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.608485e-03 | 2.584 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 2.822338e-03 | 2.549 |
| R-HSA-913531 | Interferon Signaling | 3.050611e-03 | 2.516 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.128907e-03 | 2.505 |
| R-HSA-447115 | Interleukin-12 family signaling | 3.291824e-03 | 2.483 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 4.007344e-03 | 2.397 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.007344e-03 | 2.397 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 4.202914e-03 | 2.376 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 5.056328e-03 | 2.296 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 5.288198e-03 | 2.277 |
| R-HSA-72764 | Eukaryotic Translation Termination | 5.288198e-03 | 2.277 |
| R-HSA-5260271 | Diseases of Immune System | 5.509324e-03 | 2.259 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 5.509324e-03 | 2.259 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.925632e-03 | 2.227 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 6.362376e-03 | 2.196 |
| R-HSA-2408522 | Selenoamino acid metabolism | 6.150417e-03 | 2.211 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 7.804107e-03 | 2.108 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 7.804107e-03 | 2.108 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.490566e-03 | 2.125 |
| R-HSA-192823 | Viral mRNA Translation | 7.432603e-03 | 2.129 |
| R-HSA-69186 | Lagging Strand Synthesis | 7.043953e-03 | 2.152 |
| R-HSA-2408557 | Selenocysteine synthesis | 6.846221e-03 | 2.165 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.071993e-03 | 2.093 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 8.610830e-03 | 2.065 |
| R-HSA-8953854 | Metabolism of RNA | 8.778470e-03 | 2.057 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 8.866958e-03 | 2.052 |
| R-HSA-75153 | Apoptotic execution phase | 8.866958e-03 | 2.052 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 9.056144e-03 | 2.043 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 9.869618e-03 | 2.006 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 1.036628e-02 | 1.984 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.091895e-02 | 1.962 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.091895e-02 | 1.962 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.141604e-02 | 1.942 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 1.131603e-02 | 1.946 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.193395e-02 | 1.923 |
| R-HSA-6798695 | Neutrophil degranulation | 1.245118e-02 | 1.905 |
| R-HSA-72649 | Translation initiation complex formation | 1.407614e-02 | 1.852 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.439256e-02 | 1.842 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 1.485144e-02 | 1.828 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.418217e-02 | 1.848 |
| R-HSA-68952 | DNA replication initiation | 1.620435e-02 | 1.790 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.560437e-02 | 1.807 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.562579e-02 | 1.806 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 1.560437e-02 | 1.807 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.560437e-02 | 1.807 |
| R-HSA-5578775 | Ion homeostasis | 1.562579e-02 | 1.806 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.643925e-02 | 1.784 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.680029e-02 | 1.775 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.804618e-02 | 1.744 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.804618e-02 | 1.744 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.727880e-02 | 1.762 |
| R-HSA-9711097 | Cellular response to starvation | 1.661819e-02 | 1.779 |
| R-HSA-5633007 | Regulation of TP53 Activity | 1.755521e-02 | 1.756 |
| R-HSA-194441 | Metabolism of non-coding RNA | 1.814467e-02 | 1.741 |
| R-HSA-191859 | snRNP Assembly | 1.814467e-02 | 1.741 |
| R-HSA-180786 | Extension of Telomeres | 1.814467e-02 | 1.741 |
| R-HSA-210990 | PECAM1 interactions | 1.861341e-02 | 1.730 |
| R-HSA-69190 | DNA strand elongation | 1.934217e-02 | 1.713 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.068837e-02 | 1.684 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.068837e-02 | 1.684 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.068837e-02 | 1.684 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.208482e-02 | 1.656 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.502855e-02 | 1.602 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.353155e-02 | 1.628 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.353155e-02 | 1.628 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.604273e-02 | 1.584 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.353155e-02 | 1.628 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.353155e-02 | 1.628 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.208482e-02 | 1.656 |
| R-HSA-381042 | PERK regulates gene expression | 2.502855e-02 | 1.602 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.353155e-02 | 1.628 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.502855e-02 | 1.602 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.338232e-02 | 1.631 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.502855e-02 | 1.602 |
| R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 2.116326e-02 | 1.674 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 2.116326e-02 | 1.674 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.287596e-02 | 1.641 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 2.666698e-02 | 1.574 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.817307e-02 | 1.550 |
| R-HSA-114294 | Activation, translocation and oligomerization of BAX | 2.912888e-02 | 1.536 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 3.151756e-02 | 1.501 |
| R-HSA-110312 | Translesion synthesis by REV1 | 3.267982e-02 | 1.486 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.879292e-02 | 1.541 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.982039e-02 | 1.525 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.961192e-02 | 1.529 |
| R-HSA-8876725 | Protein methylation | 3.267982e-02 | 1.486 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.187934e-02 | 1.496 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.982039e-02 | 1.525 |
| R-HSA-418346 | Platelet homeostasis | 3.193907e-02 | 1.496 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 3.151756e-02 | 1.501 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.957314e-02 | 1.529 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 3.283256e-02 | 1.484 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 3.326440e-02 | 1.478 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.326440e-02 | 1.478 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.326440e-02 | 1.478 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 3.326440e-02 | 1.478 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 3.326440e-02 | 1.478 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.441178e-02 | 1.463 |
| R-HSA-73930 | Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | 4.337489e-02 | 1.363 |
| R-HSA-5619111 | Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) | 4.337489e-02 | 1.363 |
| R-HSA-5603027 | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (E... | 4.337489e-02 | 1.363 |
| R-HSA-9915355 | Beta-ketothiolase deficiency | 4.337489e-02 | 1.363 |
| R-HSA-5602636 | IKBKB deficiency causes SCID | 4.337489e-02 | 1.363 |
| R-HSA-5656121 | Translesion synthesis by POLI | 3.586646e-02 | 1.445 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.916773e-02 | 1.407 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.686185e-02 | 1.329 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 3.506069e-02 | 1.455 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 4.609816e-02 | 1.336 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 4.609816e-02 | 1.336 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.042725e-02 | 1.393 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.417310e-02 | 1.355 |
| R-HSA-5693538 | Homology Directed Repair | 4.761196e-02 | 1.322 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 4.337489e-02 | 1.363 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 4.477472e-02 | 1.349 |
| R-HSA-72766 | Translation | 3.689197e-02 | 1.433 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.887836e-02 | 1.311 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.887836e-02 | 1.311 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.586646e-02 | 1.445 |
| R-HSA-2028269 | Signaling by Hippo | 4.257960e-02 | 1.371 |
| R-HSA-162587 | HIV Life Cycle | 4.709219e-02 | 1.327 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 4.257960e-02 | 1.371 |
| R-HSA-157118 | Signaling by NOTCH | 4.097130e-02 | 1.388 |
| R-HSA-9603505 | NTRK3 as a dependence receptor | 4.337489e-02 | 1.363 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 3.506069e-02 | 1.455 |
| R-HSA-9675135 | Diseases of DNA repair | 4.686185e-02 | 1.329 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.558104e-02 | 1.449 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.572066e-02 | 1.447 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.197496e-02 | 1.377 |
| R-HSA-422475 | Axon guidance | 4.326844e-02 | 1.364 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.849978e-02 | 1.314 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.935490e-02 | 1.307 |
| R-HSA-110320 | Translesion Synthesis by POLH | 4.971957e-02 | 1.303 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.279618e-02 | 1.277 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.279618e-02 | 1.277 |
| R-HSA-73893 | DNA Damage Bypass | 5.340523e-02 | 1.272 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 5.344007e-02 | 1.272 |
| R-HSA-5578997 | Defective AHCY causes HMAHCHD | 5.741272e-02 | 1.241 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 5.741272e-02 | 1.241 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 5.741272e-02 | 1.241 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 5.725602e-02 | 1.242 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 6.116383e-02 | 1.214 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 6.116383e-02 | 1.214 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.924116e-02 | 1.160 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 6.516001e-02 | 1.186 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 6.516001e-02 | 1.186 |
| R-HSA-9843745 | Adipogenesis | 6.868363e-02 | 1.163 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 5.741272e-02 | 1.241 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 6.116383e-02 | 1.214 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.232743e-02 | 1.205 |
| R-HSA-6809371 | Formation of the cornified envelope | 5.550701e-02 | 1.256 |
| R-HSA-9669938 | Signaling by KIT in disease | 6.516001e-02 | 1.186 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 6.728483e-02 | 1.172 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 6.728483e-02 | 1.172 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 5.741272e-02 | 1.241 |
| R-HSA-210991 | Basigin interactions | 5.725602e-02 | 1.242 |
| R-HSA-73884 | Base Excision Repair | 6.053637e-02 | 1.218 |
| R-HSA-1236974 | ER-Phagosome pathway | 5.877319e-02 | 1.231 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.550701e-02 | 1.256 |
| R-HSA-74160 | Gene expression (Transcription) | 5.933939e-02 | 1.227 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 6.036259e-02 | 1.219 |
| R-HSA-9755088 | Ribavirin ADME | 6.116383e-02 | 1.214 |
| R-HSA-9675108 | Nervous system development | 6.575795e-02 | 1.182 |
| R-HSA-9837999 | Mitochondrial protein degradation | 6.976797e-02 | 1.156 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.026089e-02 | 1.153 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 7.058094e-02 | 1.151 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 7.124542e-02 | 1.147 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 7.124542e-02 | 1.147 |
| R-HSA-392023 | Adrenaline signalling through Alpha-2 adrenergic receptor | 7.124542e-02 | 1.147 |
| R-HSA-5083630 | Defective LFNG causes SCDO3 | 8.487595e-02 | 1.071 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 8.487595e-02 | 1.071 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 9.830727e-02 | 1.007 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 9.830727e-02 | 1.007 |
| R-HSA-5619062 | Defective SLC1A3 causes episodic ataxia 6 (EA6) | 9.830727e-02 | 1.007 |
| R-HSA-164525 | Plus-strand DNA synthesis | 1.115423e-01 | 0.953 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.115423e-01 | 0.953 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.245838e-01 | 0.905 |
| R-HSA-162585 | Uncoating of the HIV Virion | 1.245838e-01 | 0.905 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.374347e-01 | 0.862 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.374347e-01 | 0.862 |
| R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum | 1.374347e-01 | 0.862 |
| R-HSA-162589 | Reverse Transcription of HIV RNA | 1.500978e-01 | 0.824 |
| R-HSA-164516 | Minus-strand DNA synthesis | 1.500978e-01 | 0.824 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.500978e-01 | 0.824 |
| R-HSA-9613354 | Lipophagy | 1.625757e-01 | 0.789 |
| R-HSA-201688 | WNT mediated activation of DVL | 1.625757e-01 | 0.789 |
| R-HSA-173107 | Binding and entry of HIV virion | 1.748711e-01 | 0.757 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.748711e-01 | 0.757 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.748711e-01 | 0.757 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.869868e-01 | 0.728 |
| R-HSA-2197563 | NOTCH2 intracellular domain regulates transcription | 2.106893e-01 | 0.676 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.106893e-01 | 0.676 |
| R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS | 2.106893e-01 | 0.676 |
| R-HSA-3656237 | Defective EXT2 causes exostoses 2 | 2.106893e-01 | 0.676 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.106893e-01 | 0.676 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 2.222812e-01 | 0.653 |
| R-HSA-69166 | Removal of the Flap Intermediate | 2.337036e-01 | 0.631 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.045657e-01 | 0.981 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 2.449589e-01 | 0.611 |
| R-HSA-9027284 | Erythropoietin activates RAS | 2.449589e-01 | 0.611 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.449589e-01 | 0.611 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.449589e-01 | 0.611 |
| R-HSA-8964315 | G beta:gamma signalling through BTK | 2.449589e-01 | 0.611 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.560495e-01 | 0.592 |
| R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type | 2.669780e-01 | 0.574 |
| R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 | 2.669780e-01 | 0.574 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.777465e-01 | 0.556 |
| R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD | 2.777465e-01 | 0.556 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 1.537933e-01 | 0.813 |
| R-HSA-167161 | HIV Transcription Initiation | 1.641158e-01 | 0.785 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 1.641158e-01 | 0.785 |
| R-HSA-72187 | mRNA 3'-end processing | 2.226104e-01 | 0.652 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.280237e-01 | 0.642 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 1.548099e-01 | 0.810 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 1.548099e-01 | 0.810 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.191450e-01 | 0.659 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.092047e-01 | 0.679 |
| R-HSA-72172 | mRNA Splicing | 2.384713e-01 | 0.623 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 1.548099e-01 | 0.810 |
| R-HSA-69183 | Processive synthesis on the lagging strand | 2.449589e-01 | 0.611 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.222812e-01 | 0.653 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 1.851010e-01 | 0.733 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.115423e-01 | 0.953 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.114969e-01 | 0.675 |
| R-HSA-2424491 | DAP12 signaling | 9.991826e-02 | 1.000 |
| R-HSA-418457 | cGMP effects | 2.337036e-01 | 0.631 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.449589e-01 | 0.611 |
| R-HSA-9620244 | Long-term potentiation | 7.764511e-02 | 1.110 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.641158e-01 | 0.785 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 1.745569e-01 | 0.758 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.904071e-01 | 0.720 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.904071e-01 | 0.720 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.904071e-01 | 0.720 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.365217e-02 | 1.133 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 9.830727e-02 | 1.007 |
| R-HSA-180689 | APOBEC3G mediated resistance to HIV-1 infection | 1.989254e-01 | 0.701 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.337036e-01 | 0.631 |
| R-HSA-9664420 | Killing mechanisms | 2.560495e-01 | 0.592 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.560495e-01 | 0.592 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 1.641158e-01 | 0.785 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 2.669780e-01 | 0.574 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 1.851010e-01 | 0.733 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 1.245838e-01 | 0.905 |
| R-HSA-1268020 | Mitochondrial protein import | 2.769907e-01 | 0.558 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.641158e-01 | 0.785 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.904071e-01 | 0.720 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 2.560495e-01 | 0.592 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.745569e-01 | 0.758 |
| R-HSA-111457 | Release of apoptotic factors from the mitochondria | 1.115423e-01 | 0.953 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 1.115423e-01 | 0.953 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.115423e-01 | 0.953 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.748711e-01 | 0.757 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 1.748711e-01 | 0.757 |
| R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 7.764511e-02 | 1.110 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.449589e-01 | 0.611 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.335707e-01 | 0.874 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.883575e-01 | 0.540 |
| R-HSA-1433557 | Signaling by SCF-KIT | 1.745569e-01 | 0.758 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 1.693225e-01 | 0.771 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.010783e-01 | 0.697 |
| R-HSA-69239 | Synthesis of DNA | 1.014603e-01 | 0.994 |
| R-HSA-9020702 | Interleukin-1 signaling | 2.307210e-01 | 0.637 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 1.188436e-01 | 0.925 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 2.777465e-01 | 0.556 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.883575e-01 | 0.540 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 8.634998e-02 | 1.064 |
| R-HSA-171007 | p38MAPK events | 2.449589e-01 | 0.611 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 2.118170e-01 | 0.674 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.660493e-01 | 0.575 |
| R-HSA-2172127 | DAP12 interactions | 1.798170e-01 | 0.745 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.191450e-01 | 0.659 |
| R-HSA-418597 | G alpha (z) signalling events | 2.388762e-01 | 0.622 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.231480e-01 | 0.910 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.191450e-01 | 0.659 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.191450e-01 | 0.659 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.153137e-01 | 0.667 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.819628e-01 | 0.550 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 9.830727e-02 | 1.007 |
| R-HSA-112313 | Neurotransmitter uptake and metabolism In glial cells | 1.500978e-01 | 0.824 |
| R-HSA-210455 | Astrocytic Glutamate-Glutamine Uptake And Metabolism | 1.500978e-01 | 0.824 |
| R-HSA-2025928 | Calcineurin activates NFAT | 1.625757e-01 | 0.789 |
| R-HSA-77108 | Utilization of Ketone Bodies | 1.869868e-01 | 0.728 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.989254e-01 | 0.701 |
| R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus | 1.989254e-01 | 0.701 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.449589e-01 | 0.611 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 2.449589e-01 | 0.611 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.669780e-01 | 0.574 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 8.358567e-02 | 1.078 |
| R-HSA-202403 | TCR signaling | 2.700182e-01 | 0.569 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 9.533128e-02 | 1.021 |
| R-HSA-162906 | HIV Infection | 7.597439e-02 | 1.119 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 2.620877e-01 | 0.582 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.016482e-01 | 0.993 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.748711e-01 | 0.757 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.702658e-01 | 0.568 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.140310e-01 | 0.943 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 7.813274e-02 | 1.107 |
| R-HSA-6805567 | Keratinization | 2.439121e-01 | 0.613 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.114362e-01 | 0.953 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.500978e-01 | 0.824 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.140310e-01 | 0.943 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.140310e-01 | 0.943 |
| R-HSA-6782135 | Dual incision in TC-NER | 7.546722e-02 | 1.122 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.388762e-01 | 0.622 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.926541e-01 | 0.715 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.339606e-02 | 1.030 |
| R-HSA-114608 | Platelet degranulation | 1.603619e-01 | 0.795 |
| R-HSA-3214847 | HATs acetylate histones | 2.229904e-01 | 0.652 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 2.637907e-01 | 0.579 |
| R-HSA-9706374 | FLT3 signaling through SRC family kinases | 8.487595e-02 | 1.071 |
| R-HSA-427652 | Sodium-coupled phosphate cotransporters | 1.115423e-01 | 0.953 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.374347e-01 | 0.862 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.374347e-01 | 0.862 |
| R-HSA-6807047 | Cholesterol biosynthesis via desmosterol | 1.869868e-01 | 0.728 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.106893e-01 | 0.676 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.106893e-01 | 0.676 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 2.106893e-01 | 0.676 |
| R-HSA-75892 | Platelet Adhesion to exposed collagen | 2.222812e-01 | 0.653 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 2.337036e-01 | 0.631 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 2.449589e-01 | 0.611 |
| R-HSA-163615 | PKA activation | 2.883575e-01 | 0.540 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.715434e-01 | 0.566 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.335707e-01 | 0.874 |
| R-HSA-379724 | tRNA Aminoacylation | 2.660950e-01 | 0.575 |
| R-HSA-202433 | Generation of second messenger molecules | 1.537933e-01 | 0.813 |
| R-HSA-157579 | Telomere Maintenance | 7.764407e-02 | 1.110 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.259180e-01 | 0.900 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.255165e-02 | 1.139 |
| R-HSA-68962 | Activation of the pre-replicative complex | 9.991826e-02 | 1.000 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.140310e-01 | 0.943 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.883575e-01 | 0.540 |
| R-HSA-450294 | MAP kinase activation | 2.715434e-01 | 0.566 |
| R-HSA-69242 | S Phase | 2.319192e-01 | 0.635 |
| R-HSA-111933 | Calmodulin induced events | 1.335707e-01 | 0.874 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.904071e-01 | 0.720 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.502518e-01 | 0.602 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.803469e-01 | 0.744 |
| R-HSA-8982491 | Glycogen metabolism | 1.537933e-01 | 0.813 |
| R-HSA-73886 | Chromosome Maintenance | 1.412619e-01 | 0.850 |
| R-HSA-111997 | CaM pathway | 1.335707e-01 | 0.874 |
| R-HSA-69481 | G2/M Checkpoints | 1.603619e-01 | 0.795 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.115423e-01 | 0.953 |
| R-HSA-164944 | Nef and signal transduction | 1.245838e-01 | 0.905 |
| R-HSA-447041 | CHL1 interactions | 1.374347e-01 | 0.862 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 1.374347e-01 | 0.862 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.500978e-01 | 0.824 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 1.625757e-01 | 0.789 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.869868e-01 | 0.728 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.337036e-01 | 0.631 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.162789e-01 | 0.934 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.564237e-01 | 0.806 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 1.798170e-01 | 0.745 |
| R-HSA-69306 | DNA Replication | 2.477410e-01 | 0.606 |
| R-HSA-111996 | Ca-dependent events | 1.693225e-01 | 0.771 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.777465e-01 | 0.556 |
| R-HSA-3928664 | Ephrin signaling | 2.883575e-01 | 0.540 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.883575e-01 | 0.540 |
| R-HSA-9824443 | Parasitic Infection Pathways | 8.049735e-02 | 1.094 |
| R-HSA-9658195 | Leishmania infection | 8.049735e-02 | 1.094 |
| R-HSA-1489509 | DAG and IP3 signaling | 1.851010e-01 | 0.733 |
| R-HSA-9860276 | SLC15A4:TASL-dependent IRF5 activation | 1.115423e-01 | 0.953 |
| R-HSA-390696 | Adrenoceptors | 1.500978e-01 | 0.824 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 1.625757e-01 | 0.789 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 2.449589e-01 | 0.611 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.883575e-01 | 0.540 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.334461e-01 | 0.632 |
| R-HSA-211976 | Endogenous sterols | 2.715434e-01 | 0.566 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.205018e-01 | 0.919 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.443126e-01 | 0.612 |
| R-HSA-112043 | PLC beta mediated events | 2.715434e-01 | 0.566 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.284308e-02 | 1.138 |
| R-HSA-168249 | Innate Immune System | 2.687285e-01 | 0.571 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.092708e-01 | 0.961 |
| R-HSA-162592 | Integration of provirus | 1.989254e-01 | 0.701 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.337036e-01 | 0.631 |
| R-HSA-6784531 | tRNA processing in the nucleus | 8.637189e-02 | 1.064 |
| R-HSA-437239 | Recycling pathway of L1 | 1.957334e-01 | 0.708 |
| R-HSA-1640170 | Cell Cycle | 7.628897e-02 | 1.118 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.589387e-01 | 0.799 |
| R-HSA-70171 | Glycolysis | 8.383091e-02 | 1.077 |
| R-HSA-168256 | Immune System | 2.863500e-01 | 0.543 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 9.050173e-02 | 1.043 |
| R-HSA-1483249 | Inositol phosphate metabolism | 2.779754e-01 | 0.556 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 1.374347e-01 | 0.862 |
| R-HSA-75893 | TNF signaling | 2.443126e-01 | 0.612 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.628169e-01 | 0.788 |
| R-HSA-397014 | Muscle contraction | 2.604267e-01 | 0.584 |
| R-HSA-9824446 | Viral Infection Pathways | 1.283784e-01 | 0.892 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 2.106893e-01 | 0.676 |
| R-HSA-9683610 | Maturation of nucleoprotein | 2.222812e-01 | 0.653 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.237060e-01 | 0.908 |
| R-HSA-9748787 | Azathioprine ADME | 2.118170e-01 | 0.674 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 7.723110e-02 | 1.112 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.500978e-01 | 0.824 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.989254e-01 | 0.701 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.449589e-01 | 0.611 |
| R-HSA-70326 | Glucose metabolism | 1.307841e-01 | 0.883 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.904071e-01 | 0.720 |
| R-HSA-5663205 | Infectious disease | 1.869250e-01 | 0.728 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.436058e-01 | 0.843 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 2.669780e-01 | 0.574 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 1.162789e-01 | 0.934 |
| R-HSA-72312 | rRNA processing | 8.237936e-02 | 1.084 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 8.634998e-02 | 1.064 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 1.037759e-01 | 0.984 |
| R-HSA-109581 | Apoptosis | 1.301492e-01 | 0.886 |
| R-HSA-449147 | Signaling by Interleukins | 1.003959e-01 | 0.998 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 8.196149e-02 | 1.086 |
| R-HSA-196780 | Biotin transport and metabolism | 2.449589e-01 | 0.611 |
| R-HSA-211000 | Gene Silencing by RNA | 1.014603e-01 | 0.994 |
| R-HSA-69205 | G1/S-Specific Transcription | 1.335707e-01 | 0.874 |
| R-HSA-111471 | Apoptotic factor-mediated response | 2.883575e-01 | 0.540 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.785913e-02 | 1.009 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 2.777465e-01 | 0.556 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 9.916907e-02 | 1.004 |
| R-HSA-5576891 | Cardiac conduction | 1.745527e-01 | 0.758 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 1.237060e-01 | 0.908 |
| R-HSA-5357801 | Programmed Cell Death | 2.411875e-01 | 0.618 |
| R-HSA-9020558 | Interleukin-2 signaling | 1.869868e-01 | 0.728 |
| R-HSA-9679506 | SARS-CoV Infections | 8.786034e-02 | 1.056 |
| R-HSA-5619102 | SLC transporter disorders | 1.411240e-01 | 0.850 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.798170e-01 | 0.745 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.878770e-01 | 0.541 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.889380e-01 | 0.724 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.618483e-01 | 0.791 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.894656e-01 | 0.538 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.899526e-01 | 0.538 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 2.933139e-01 | 0.533 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 2.979589e-01 | 0.526 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.979589e-01 | 0.526 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.988133e-01 | 0.525 |
| R-HSA-912631 | Regulation of signaling by CBL | 2.988133e-01 | 0.525 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.988133e-01 | 0.525 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 2.988133e-01 | 0.525 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.988133e-01 | 0.525 |
| R-HSA-392517 | Rap1 signalling | 2.988133e-01 | 0.525 |
| R-HSA-9694631 | Maturation of nucleoprotein | 2.988133e-01 | 0.525 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.010502e-01 | 0.521 |
| R-HSA-373760 | L1CAM interactions | 3.019671e-01 | 0.520 |
| R-HSA-112040 | G-protein mediated events | 3.041700e-01 | 0.517 |
| R-HSA-109582 | Hemostasis | 3.047033e-01 | 0.516 |
| R-HSA-1592230 | Mitochondrial biogenesis | 3.059780e-01 | 0.514 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 3.091161e-01 | 0.510 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.091161e-01 | 0.510 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.091161e-01 | 0.510 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.091161e-01 | 0.510 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.091161e-01 | 0.510 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 3.091161e-01 | 0.510 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 3.091161e-01 | 0.510 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 3.091161e-01 | 0.510 |
| R-HSA-9629569 | Protein hydroxylation | 3.091161e-01 | 0.510 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.095872e-01 | 0.509 |
| R-HSA-167172 | Transcription of the HIV genome | 3.095872e-01 | 0.509 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.095872e-01 | 0.509 |
| R-HSA-68875 | Mitotic Prophase | 3.180221e-01 | 0.498 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.192681e-01 | 0.496 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 3.192681e-01 | 0.496 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 3.192681e-01 | 0.496 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 3.192681e-01 | 0.496 |
| R-HSA-167044 | Signalling to RAS | 3.192681e-01 | 0.496 |
| R-HSA-198753 | ERK/MAPK targets | 3.192681e-01 | 0.496 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.192681e-01 | 0.496 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 3.192681e-01 | 0.496 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 3.203954e-01 | 0.494 |
| R-HSA-448424 | Interleukin-17 signaling | 3.203954e-01 | 0.494 |
| R-HSA-3247509 | Chromatin modifying enzymes | 3.228589e-01 | 0.491 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.257844e-01 | 0.487 |
| R-HSA-3000178 | ECM proteoglycans | 3.257844e-01 | 0.487 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 3.292716e-01 | 0.482 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 3.292716e-01 | 0.482 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 3.292716e-01 | 0.482 |
| R-HSA-9694614 | Attachment and Entry | 3.292716e-01 | 0.482 |
| R-HSA-175474 | Assembly Of The HIV Virion | 3.292716e-01 | 0.482 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 3.292716e-01 | 0.482 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.311624e-01 | 0.480 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 3.365283e-01 | 0.473 |
| R-HSA-4086398 | Ca2+ pathway | 3.365283e-01 | 0.473 |
| R-HSA-162582 | Signal Transduction | 3.382341e-01 | 0.471 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 3.391287e-01 | 0.470 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.391287e-01 | 0.470 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 3.391287e-01 | 0.470 |
| R-HSA-8964038 | LDL clearance | 3.391287e-01 | 0.470 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 3.418815e-01 | 0.466 |
| R-HSA-69206 | G1/S Transition | 3.421213e-01 | 0.466 |
| R-HSA-194138 | Signaling by VEGF | 3.421213e-01 | 0.466 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 3.472212e-01 | 0.459 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 3.488415e-01 | 0.457 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.488415e-01 | 0.457 |
| R-HSA-74182 | Ketone body metabolism | 3.488415e-01 | 0.457 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.488415e-01 | 0.457 |
| R-HSA-982772 | Growth hormone receptor signaling | 3.488415e-01 | 0.457 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.488415e-01 | 0.457 |
| R-HSA-5689603 | UCH proteinases | 3.525465e-01 | 0.453 |
| R-HSA-9694635 | Translation of Structural Proteins | 3.578568e-01 | 0.446 |
| R-HSA-202430 | Translocation of ZAP-70 to Immunological synapse | 3.584122e-01 | 0.446 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.584122e-01 | 0.446 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.584122e-01 | 0.446 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 3.584122e-01 | 0.446 |
| R-HSA-429947 | Deadenylation of mRNA | 3.584122e-01 | 0.446 |
| R-HSA-9865881 | Complex III assembly | 3.584122e-01 | 0.446 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 3.584122e-01 | 0.446 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.605650e-01 | 0.443 |
| R-HSA-416482 | G alpha (12/13) signalling events | 3.631513e-01 | 0.440 |
| R-HSA-191273 | Cholesterol biosynthesis | 3.631513e-01 | 0.440 |
| R-HSA-216083 | Integrin cell surface interactions | 3.631513e-01 | 0.440 |
| R-HSA-4839726 | Chromatin organization | 3.663869e-01 | 0.436 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.678427e-01 | 0.434 |
| R-HSA-9839394 | TGFBR3 expression | 3.678427e-01 | 0.434 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 3.678427e-01 | 0.434 |
| R-HSA-9659379 | Sensory processing of sound | 3.684295e-01 | 0.434 |
| R-HSA-983712 | Ion channel transport | 3.694944e-01 | 0.432 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.771353e-01 | 0.424 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 3.771353e-01 | 0.424 |
| R-HSA-525793 | Myogenesis | 3.771353e-01 | 0.424 |
| R-HSA-5689901 | Metalloprotease DUBs | 3.771353e-01 | 0.424 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 3.771353e-01 | 0.424 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 3.771353e-01 | 0.424 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.771353e-01 | 0.424 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.771353e-01 | 0.424 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.771353e-01 | 0.424 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 3.771353e-01 | 0.424 |
| R-HSA-977225 | Amyloid fiber formation | 3.789339e-01 | 0.421 |
| R-HSA-392499 | Metabolism of proteins | 3.797139e-01 | 0.421 |
| R-HSA-212436 | Generic Transcription Pathway | 3.820237e-01 | 0.418 |
| R-HSA-5688426 | Deubiquitination | 3.838584e-01 | 0.416 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.862918e-01 | 0.413 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 3.862918e-01 | 0.413 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 3.862918e-01 | 0.413 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.862918e-01 | 0.413 |
| R-HSA-8949613 | Cristae formation | 3.862918e-01 | 0.413 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.862918e-01 | 0.413 |
| R-HSA-201451 | Signaling by BMP | 3.862918e-01 | 0.413 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.862918e-01 | 0.413 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 3.862918e-01 | 0.413 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.862918e-01 | 0.413 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.940096e-01 | 0.404 |
| R-HSA-73857 | RNA Polymerase II Transcription | 3.943385e-01 | 0.404 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.953142e-01 | 0.403 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.953142e-01 | 0.403 |
| R-HSA-5620971 | Pyroptosis | 3.953142e-01 | 0.403 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 3.997182e-01 | 0.398 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 3.997182e-01 | 0.398 |
| R-HSA-1500620 | Meiosis | 3.997182e-01 | 0.398 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 3.997182e-01 | 0.398 |
| R-HSA-9006335 | Signaling by Erythropoietin | 4.042046e-01 | 0.393 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.042046e-01 | 0.393 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.042046e-01 | 0.393 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 4.042046e-01 | 0.393 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 4.042046e-01 | 0.393 |
| R-HSA-1643685 | Disease | 4.047609e-01 | 0.393 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.048642e-01 | 0.393 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.048642e-01 | 0.393 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.066007e-01 | 0.391 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 4.099892e-01 | 0.387 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 4.129648e-01 | 0.384 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.129648e-01 | 0.384 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.129648e-01 | 0.384 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.150926e-01 | 0.382 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.150926e-01 | 0.382 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.159192e-01 | 0.381 |
| R-HSA-162588 | Budding and maturation of HIV virion | 4.215967e-01 | 0.375 |
| R-HSA-182971 | EGFR downregulation | 4.215967e-01 | 0.375 |
| R-HSA-399719 | Trafficking of AMPA receptors | 4.215967e-01 | 0.375 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 4.215967e-01 | 0.375 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.215967e-01 | 0.375 |
| R-HSA-2024096 | HS-GAG degradation | 4.301022e-01 | 0.366 |
| R-HSA-1538133 | G0 and Early G1 | 4.301022e-01 | 0.366 |
| R-HSA-202424 | Downstream TCR signaling | 4.302687e-01 | 0.366 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.302687e-01 | 0.366 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.384831e-01 | 0.358 |
| R-HSA-354192 | Integrin signaling | 4.384831e-01 | 0.358 |
| R-HSA-9930044 | Nuclear RNA decay | 4.384831e-01 | 0.358 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.384831e-01 | 0.358 |
| R-HSA-397795 | G-protein beta:gamma signalling | 4.384831e-01 | 0.358 |
| R-HSA-159418 | Recycling of bile acids and salts | 4.384831e-01 | 0.358 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 4.384831e-01 | 0.358 |
| R-HSA-166520 | Signaling by NTRKs | 4.448008e-01 | 0.352 |
| R-HSA-391251 | Protein folding | 4.452350e-01 | 0.351 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 4.452350e-01 | 0.351 |
| R-HSA-390522 | Striated Muscle Contraction | 4.467414e-01 | 0.350 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.467414e-01 | 0.350 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.467414e-01 | 0.350 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 4.467414e-01 | 0.350 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 4.467414e-01 | 0.350 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 4.501752e-01 | 0.347 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.548786e-01 | 0.342 |
| R-HSA-1971475 | Glycosaminoglycan-protein linkage region biosynthesis | 4.548786e-01 | 0.342 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 4.548786e-01 | 0.342 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.548786e-01 | 0.342 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.548786e-01 | 0.342 |
| R-HSA-392518 | Signal amplification | 4.548786e-01 | 0.342 |
| R-HSA-5673000 | RAF activation | 4.548786e-01 | 0.342 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 4.548786e-01 | 0.342 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 4.548786e-01 | 0.342 |
| R-HSA-446652 | Interleukin-1 family signaling | 4.601041e-01 | 0.337 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.628967e-01 | 0.335 |
| R-HSA-2408508 | Metabolism of ingested SeMet, Sec, MeSec into H2Se | 4.628967e-01 | 0.335 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.628967e-01 | 0.335 |
| R-HSA-187687 | Signalling to ERKs | 4.628967e-01 | 0.335 |
| R-HSA-73887 | Death Receptor Signaling | 4.676887e-01 | 0.330 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 4.696846e-01 | 0.328 |
| R-HSA-2022928 | HS-GAG biosynthesis | 4.707973e-01 | 0.327 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.707973e-01 | 0.327 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.707973e-01 | 0.327 |
| R-HSA-9682385 | FLT3 signaling in disease | 4.707973e-01 | 0.327 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.707973e-01 | 0.327 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 4.707973e-01 | 0.327 |
| R-HSA-1989781 | PPARA activates gene expression | 4.714633e-01 | 0.327 |
| R-HSA-4641258 | Degradation of DVL | 4.785822e-01 | 0.320 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 4.785822e-01 | 0.320 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.785822e-01 | 0.320 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.785822e-01 | 0.320 |
| R-HSA-419037 | NCAM1 interactions | 4.785822e-01 | 0.320 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 4.785822e-01 | 0.320 |
| R-HSA-196757 | Metabolism of folate and pterines | 4.785822e-01 | 0.320 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.789764e-01 | 0.320 |
| R-HSA-9610379 | HCMV Late Events | 4.789764e-01 | 0.320 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 4.815935e-01 | 0.317 |
| R-HSA-877300 | Interferon gamma signaling | 4.864396e-01 | 0.313 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.887767e-01 | 0.311 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.887767e-01 | 0.311 |
| R-HSA-73894 | DNA Repair | 4.921568e-01 | 0.308 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.938115e-01 | 0.306 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 4.938115e-01 | 0.306 |
| R-HSA-71336 | Pentose phosphate pathway | 4.938115e-01 | 0.306 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.938115e-01 | 0.306 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.938115e-01 | 0.306 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.981609e-01 | 0.303 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.981609e-01 | 0.303 |
| R-HSA-1483255 | PI Metabolism | 4.981609e-01 | 0.303 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 4.983692e-01 | 0.302 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 5.011458e-01 | 0.300 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 5.012593e-01 | 0.300 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.012593e-01 | 0.300 |
| R-HSA-111885 | Opioid Signalling | 5.074349e-01 | 0.295 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.074349e-01 | 0.295 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.085979e-01 | 0.294 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 5.085979e-01 | 0.294 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.085979e-01 | 0.294 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.085979e-01 | 0.294 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.085979e-01 | 0.294 |
| R-HSA-9694548 | Maturation of spike protein | 5.085979e-01 | 0.294 |
| R-HSA-9607240 | FLT3 Signaling | 5.085979e-01 | 0.294 |
| R-HSA-5674135 | MAP2K and MAPK activation | 5.158289e-01 | 0.287 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 5.158289e-01 | 0.287 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.158289e-01 | 0.287 |
| R-HSA-9683701 | Translation of Structural Proteins | 5.158289e-01 | 0.287 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 5.165971e-01 | 0.287 |
| R-HSA-991365 | Activation of GABAB receptors | 5.229540e-01 | 0.282 |
| R-HSA-977444 | GABA B receptor activation | 5.229540e-01 | 0.282 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 5.229540e-01 | 0.282 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.229540e-01 | 0.282 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 5.275074e-01 | 0.278 |
| R-HSA-9710421 | Defective pyroptosis | 5.299747e-01 | 0.276 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 5.299747e-01 | 0.276 |
| R-HSA-72306 | tRNA processing | 5.300886e-01 | 0.276 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.345808e-01 | 0.272 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.345808e-01 | 0.272 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.368925e-01 | 0.270 |
| R-HSA-156581 | Methylation | 5.368925e-01 | 0.270 |
| R-HSA-69231 | Cyclin D associated events in G1 | 5.368925e-01 | 0.270 |
| R-HSA-69236 | G1 Phase | 5.368925e-01 | 0.270 |
| R-HSA-375280 | Amine ligand-binding receptors | 5.368925e-01 | 0.270 |
| R-HSA-5683826 | Surfactant metabolism | 5.368925e-01 | 0.270 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.383028e-01 | 0.269 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 5.390049e-01 | 0.268 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 5.390049e-01 | 0.268 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.406768e-01 | 0.267 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.406768e-01 | 0.267 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.406768e-01 | 0.267 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.437089e-01 | 0.265 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 5.437089e-01 | 0.265 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 5.437089e-01 | 0.265 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.437089e-01 | 0.265 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 5.437089e-01 | 0.265 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 5.437089e-01 | 0.265 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.437089e-01 | 0.265 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.504253e-01 | 0.259 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.516547e-01 | 0.258 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.564105e-01 | 0.255 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 5.570434e-01 | 0.254 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 5.570434e-01 | 0.254 |
| R-HSA-9634597 | GPER1 signaling | 5.635644e-01 | 0.249 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.635644e-01 | 0.249 |
| R-HSA-70263 | Gluconeogenesis | 5.635644e-01 | 0.249 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.649376e-01 | 0.248 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 5.658204e-01 | 0.247 |
| R-HSA-9766229 | Degradation of CDH1 | 5.699898e-01 | 0.244 |
| R-HSA-112315 | Transmission across Chemical Synapses | 5.736080e-01 | 0.241 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 5.816377e-01 | 0.235 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.825593e-01 | 0.235 |
| R-HSA-912446 | Meiotic recombination | 5.825593e-01 | 0.235 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 5.825593e-01 | 0.235 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.857388e-01 | 0.232 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.887062e-01 | 0.230 |
| R-HSA-6794361 | Neurexins and neuroligins | 5.887062e-01 | 0.230 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.887062e-01 | 0.230 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 5.938519e-01 | 0.226 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.938519e-01 | 0.226 |
| R-HSA-1221632 | Meiotic synapsis | 5.947630e-01 | 0.226 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 5.947630e-01 | 0.226 |
| R-HSA-156588 | Glucuronidation | 6.007309e-01 | 0.221 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.018462e-01 | 0.221 |
| R-HSA-2132295 | MHC class II antigen presentation | 6.018462e-01 | 0.221 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.049350e-01 | 0.218 |
| R-HSA-68877 | Mitotic Prometaphase | 6.076154e-01 | 0.216 |
| R-HSA-193648 | NRAGE signals death through JNK | 6.124054e-01 | 0.213 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.124054e-01 | 0.213 |
| R-HSA-177929 | Signaling by EGFR | 6.124054e-01 | 0.213 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.124054e-01 | 0.213 |
| R-HSA-1266738 | Developmental Biology | 6.145472e-01 | 0.211 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.170823e-01 | 0.210 |
| R-HSA-9609690 | HCMV Early Events | 6.170823e-01 | 0.210 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 6.174788e-01 | 0.209 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.181146e-01 | 0.209 |
| R-HSA-5621480 | Dectin-2 family | 6.181146e-01 | 0.209 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 6.237400e-01 | 0.205 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.237400e-01 | 0.205 |
| R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | 6.292829e-01 | 0.201 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.292829e-01 | 0.201 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.326377e-01 | 0.199 |
| R-HSA-977443 | GABA receptor activation | 6.347445e-01 | 0.197 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.347445e-01 | 0.197 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.347445e-01 | 0.197 |
| R-HSA-1474165 | Reproduction | 6.363537e-01 | 0.196 |
| R-HSA-445717 | Aquaporin-mediated transport | 6.401259e-01 | 0.194 |
| R-HSA-446728 | Cell junction organization | 6.436024e-01 | 0.191 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.436976e-01 | 0.191 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 6.454284e-01 | 0.190 |
| R-HSA-9707616 | Heme signaling | 6.454284e-01 | 0.190 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 6.454284e-01 | 0.190 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.506531e-01 | 0.187 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.506531e-01 | 0.187 |
| R-HSA-6799198 | Complex I biogenesis | 6.506531e-01 | 0.187 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 6.506531e-01 | 0.187 |
| R-HSA-373755 | Semaphorin interactions | 6.506531e-01 | 0.187 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.506531e-01 | 0.187 |
| R-HSA-5690714 | CD22 mediated BCR regulation | 6.558011e-01 | 0.183 |
| R-HSA-211981 | Xenobiotics | 6.558011e-01 | 0.183 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 6.615465e-01 | 0.179 |
| R-HSA-163685 | Integration of energy metabolism | 6.615465e-01 | 0.179 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.650293e-01 | 0.177 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.658716e-01 | 0.177 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.677828e-01 | 0.175 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.684833e-01 | 0.175 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.706079e-01 | 0.174 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.707963e-01 | 0.173 |
| R-HSA-196807 | Nicotinate metabolism | 6.707963e-01 | 0.173 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 6.707963e-01 | 0.173 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 6.707963e-01 | 0.173 |
| R-HSA-6807070 | PTEN Regulation | 6.719085e-01 | 0.173 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.753052e-01 | 0.170 |
| R-HSA-9664407 | Parasite infection | 6.753052e-01 | 0.170 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.753052e-01 | 0.170 |
| R-HSA-5218859 | Regulated Necrosis | 6.756487e-01 | 0.170 |
| R-HSA-68882 | Mitotic Anaphase | 6.789780e-01 | 0.168 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.817330e-01 | 0.166 |
| R-HSA-418990 | Adherens junctions interactions | 6.844705e-01 | 0.165 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.851408e-01 | 0.164 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 6.886077e-01 | 0.162 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.897826e-01 | 0.161 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 6.897826e-01 | 0.161 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.897826e-01 | 0.161 |
| R-HSA-975634 | Retinoid metabolism and transport | 6.897826e-01 | 0.161 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.897826e-01 | 0.161 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 6.897826e-01 | 0.161 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.918629e-01 | 0.160 |
| R-HSA-195721 | Signaling by WNT | 6.929838e-01 | 0.159 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 6.943563e-01 | 0.158 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.988628e-01 | 0.156 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.988628e-01 | 0.156 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.014609e-01 | 0.154 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.033031e-01 | 0.153 |
| R-HSA-9013694 | Signaling by NOTCH4 | 7.033031e-01 | 0.153 |
| R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules | 7.033031e-01 | 0.153 |
| R-HSA-380287 | Centrosome maturation | 7.076783e-01 | 0.150 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.076783e-01 | 0.150 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 7.076783e-01 | 0.150 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 7.108103e-01 | 0.148 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 7.108103e-01 | 0.148 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.119892e-01 | 0.148 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.119892e-01 | 0.148 |
| R-HSA-68886 | M Phase | 7.124160e-01 | 0.147 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 7.138722e-01 | 0.146 |
| R-HSA-1280218 | Adaptive Immune System | 7.144703e-01 | 0.146 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.159616e-01 | 0.145 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 7.162368e-01 | 0.145 |
| R-HSA-9609507 | Protein localization | 7.199146e-01 | 0.143 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.204220e-01 | 0.142 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.204220e-01 | 0.142 |
| R-HSA-4086400 | PCP/CE pathway | 7.204220e-01 | 0.142 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.227803e-01 | 0.141 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.245457e-01 | 0.140 |
| R-HSA-5579029 | Metabolic disorders of biological oxidation enzymes | 7.245457e-01 | 0.140 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.286088e-01 | 0.138 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.286088e-01 | 0.138 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 7.286088e-01 | 0.138 |
| R-HSA-9612973 | Autophagy | 7.287774e-01 | 0.137 |
| R-HSA-15869 | Metabolism of nucleotides | 7.307755e-01 | 0.136 |
| R-HSA-112316 | Neuronal System | 7.314808e-01 | 0.136 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 7.326123e-01 | 0.135 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.326123e-01 | 0.135 |
| R-HSA-1500931 | Cell-Cell communication | 7.331208e-01 | 0.135 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.404436e-01 | 0.131 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 7.404436e-01 | 0.131 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 7.442732e-01 | 0.128 |
| R-HSA-2467813 | Separation of Sister Chromatids | 7.512589e-01 | 0.124 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 7.554277e-01 | 0.122 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 7.554277e-01 | 0.122 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 7.592687e-01 | 0.120 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.625935e-01 | 0.118 |
| R-HSA-9663891 | Selective autophagy | 7.625935e-01 | 0.118 |
| R-HSA-9645723 | Diseases of programmed cell death | 7.625935e-01 | 0.118 |
| R-HSA-9609646 | HCMV Infection | 7.629845e-01 | 0.117 |
| R-HSA-421270 | Cell-cell junction organization | 7.651615e-01 | 0.116 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 7.695501e-01 | 0.114 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.721244e-01 | 0.112 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.758049e-01 | 0.110 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 7.795483e-01 | 0.108 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.796063e-01 | 0.108 |
| R-HSA-2029481 | FCGR activation | 7.828603e-01 | 0.106 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.860665e-01 | 0.105 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.892255e-01 | 0.103 |
| R-HSA-2168880 | Scavenging of heme from plasma | 7.923380e-01 | 0.101 |
| R-HSA-2559583 | Cellular Senescence | 7.937649e-01 | 0.100 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 7.954048e-01 | 0.099 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.954048e-01 | 0.099 |
| R-HSA-9711123 | Cellular response to chemical stress | 7.997453e-01 | 0.097 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 8.005662e-01 | 0.097 |
| R-HSA-422356 | Regulation of insulin secretion | 8.014037e-01 | 0.096 |
| R-HSA-3781865 | Diseases of glycosylation | 8.027888e-01 | 0.095 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 8.043372e-01 | 0.095 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 8.043372e-01 | 0.095 |
| R-HSA-382556 | ABC-family proteins mediated transport | 8.072275e-01 | 0.093 |
| R-HSA-5617833 | Cilium Assembly | 8.156701e-01 | 0.088 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.183696e-01 | 0.087 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.197944e-01 | 0.086 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.207652e-01 | 0.086 |
| R-HSA-9833110 | RSV-host interactions | 8.210535e-01 | 0.086 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.288703e-01 | 0.082 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.288703e-01 | 0.082 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.313996e-01 | 0.080 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.354789e-01 | 0.078 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.354789e-01 | 0.078 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 8.363471e-01 | 0.078 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.392032e-01 | 0.076 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 8.411500e-01 | 0.075 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.651633e-01 | 0.063 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.673724e-01 | 0.062 |
| R-HSA-9748784 | Drug ADME | 8.679090e-01 | 0.062 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.691237e-01 | 0.061 |
| R-HSA-597592 | Post-translational protein modification | 8.728970e-01 | 0.059 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.797269e-01 | 0.056 |
| R-HSA-382551 | Transport of small molecules | 8.798685e-01 | 0.056 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.803231e-01 | 0.055 |
| R-HSA-8957322 | Metabolism of steroids | 8.849175e-01 | 0.053 |
| R-HSA-9909396 | Circadian clock | 8.889231e-01 | 0.051 |
| R-HSA-1474244 | Extracellular matrix organization | 8.929162e-01 | 0.049 |
| R-HSA-8939211 | ESR-mediated signaling | 8.943914e-01 | 0.048 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.968731e-01 | 0.047 |
| R-HSA-5668914 | Diseases of metabolism | 8.994966e-01 | 0.046 |
| R-HSA-1632852 | Macroautophagy | 9.043203e-01 | 0.044 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 9.043203e-01 | 0.044 |
| R-HSA-2187338 | Visual phototransduction | 9.138147e-01 | 0.039 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.175909e-01 | 0.037 |
| R-HSA-416476 | G alpha (q) signalling events | 9.236453e-01 | 0.034 |
| R-HSA-5653656 | Vesicle-mediated transport | 9.263029e-01 | 0.033 |
| R-HSA-199991 | Membrane Trafficking | 9.326210e-01 | 0.030 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 9.356358e-01 | 0.029 |
| R-HSA-418555 | G alpha (s) signalling events | 9.406837e-01 | 0.027 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.415643e-01 | 0.026 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 9.441287e-01 | 0.025 |
| R-HSA-611105 | Respiratory electron transport | 9.465810e-01 | 0.024 |
| R-HSA-1483257 | Phospholipid metabolism | 9.478091e-01 | 0.023 |
| R-HSA-69275 | G2/M Transition | 9.526089e-01 | 0.021 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.526089e-01 | 0.021 |
| R-HSA-418594 | G alpha (i) signalling events | 9.531396e-01 | 0.021 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.540069e-01 | 0.020 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.573248e-01 | 0.019 |
| R-HSA-211859 | Biological oxidations | 9.611250e-01 | 0.017 |
| R-HSA-428157 | Sphingolipid metabolism | 9.621447e-01 | 0.017 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.707227e-01 | 0.013 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 9.779043e-01 | 0.010 |
| R-HSA-388396 | GPCR downstream signalling | 9.786493e-01 | 0.009 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.852997e-01 | 0.006 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.854002e-01 | 0.006 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.889564e-01 | 0.005 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.898853e-01 | 0.004 |
| R-HSA-372790 | Signaling by GPCR | 9.905988e-01 | 0.004 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.978737e-01 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 9.989426e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.996608e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.997073e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999991e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
VRK2 |
0.889 | 0.018 | 1 | 0.908 |
VRK1 |
0.888 | -0.002 | 2 | 0.856 |
GAK |
0.888 | -0.059 | 1 | 0.818 |
PKR |
0.886 | 0.064 | 1 | 0.858 |
TNIK |
0.883 | 0.065 | 3 | 0.897 |
LRRK2 |
0.881 | -0.090 | 2 | 0.877 |
NEK1 |
0.881 | -0.013 | 1 | 0.801 |
TAK1 |
0.881 | -0.099 | 1 | 0.832 |
EEF2K |
0.880 | 0.061 | 3 | 0.894 |
MINK |
0.878 | -0.024 | 1 | 0.785 |
HGK |
0.877 | 0.031 | 3 | 0.892 |
GCK |
0.877 | -0.032 | 1 | 0.789 |
ASK1 |
0.877 | -0.117 | 1 | 0.775 |
TAO2 |
0.877 | -0.022 | 2 | 0.878 |
LKB1 |
0.876 | -0.000 | -3 | 0.819 |
NEK5 |
0.876 | -0.002 | 1 | 0.831 |
KHS1 |
0.876 | 0.031 | 1 | 0.768 |
BMPR2 |
0.876 | -0.068 | -2 | 0.905 |
PRP4 |
0.875 | 0.292 | -3 | 0.798 |
MYO3B |
0.875 | 0.040 | 2 | 0.854 |
NIK |
0.875 | -0.021 | -3 | 0.822 |
OSR1 |
0.875 | 0.007 | 2 | 0.827 |
MST1 |
0.874 | -0.081 | 1 | 0.789 |
MAP3K15 |
0.874 | -0.046 | 1 | 0.786 |
TTK |
0.873 | -0.031 | -2 | 0.841 |
DAPK2 |
0.873 | 0.014 | -3 | 0.796 |
MEKK6 |
0.873 | -0.030 | 1 | 0.813 |
NLK |
0.873 | 0.288 | 1 | 0.913 |
JNK2 |
0.872 | 0.311 | 1 | 0.754 |
MST2 |
0.872 | -0.091 | 1 | 0.802 |
MEK1 |
0.872 | -0.187 | 2 | 0.869 |
CAMKK2 |
0.871 | -0.095 | -2 | 0.780 |
CAMLCK |
0.871 | 0.034 | -2 | 0.895 |
JNK3 |
0.871 | 0.283 | 1 | 0.791 |
MYO3A |
0.871 | -0.030 | 1 | 0.792 |
BRAF |
0.871 | -0.129 | -4 | 0.879 |
KHS2 |
0.871 | 0.037 | 1 | 0.778 |
MEKK2 |
0.871 | -0.102 | 2 | 0.831 |
PDK1 |
0.871 | -0.115 | 1 | 0.794 |
CAMKK1 |
0.870 | -0.108 | -2 | 0.785 |
MST3 |
0.870 | 0.035 | 2 | 0.872 |
TAO3 |
0.870 | -0.020 | 1 | 0.813 |
MEK5 |
0.870 | -0.242 | 2 | 0.853 |
PRPK |
0.868 | -0.046 | -1 | 0.892 |
YSK1 |
0.868 | -0.023 | 2 | 0.838 |
BIKE |
0.868 | -0.048 | 1 | 0.676 |
NEK4 |
0.867 | -0.089 | 1 | 0.788 |
STLK3 |
0.867 | -0.138 | 1 | 0.775 |
P38A |
0.867 | 0.263 | 1 | 0.817 |
HPK1 |
0.867 | -0.047 | 1 | 0.763 |
ALK4 |
0.866 | -0.035 | -2 | 0.832 |
NEK8 |
0.865 | -0.137 | 2 | 0.851 |
MPSK1 |
0.865 | 0.022 | 1 | 0.799 |
DLK |
0.865 | -0.161 | 1 | 0.854 |
MEKK1 |
0.865 | -0.125 | 1 | 0.830 |
MOS |
0.864 | 0.023 | 1 | 0.880 |
P38B |
0.864 | 0.278 | 1 | 0.760 |
CAMK1B |
0.863 | -0.032 | -3 | 0.785 |
MEK2 |
0.862 | -0.214 | 2 | 0.833 |
ANKRD3 |
0.862 | -0.160 | 1 | 0.852 |
ALPHAK3 |
0.862 | -0.123 | -1 | 0.815 |
MLK2 |
0.862 | 0.029 | 2 | 0.846 |
ATR |
0.862 | 0.018 | 1 | 0.856 |
LATS1 |
0.861 | 0.010 | -3 | 0.803 |
YSK4 |
0.861 | -0.078 | 1 | 0.775 |
LOK |
0.860 | -0.016 | -2 | 0.803 |
NEK11 |
0.860 | -0.195 | 1 | 0.790 |
ICK |
0.860 | 0.082 | -3 | 0.761 |
CDKL1 |
0.860 | 0.016 | -3 | 0.722 |
DMPK1 |
0.860 | 0.041 | -3 | 0.676 |
ROCK2 |
0.859 | 0.049 | -3 | 0.717 |
ALK2 |
0.859 | -0.014 | -2 | 0.809 |
PBK |
0.859 | -0.080 | 1 | 0.732 |
ZAK |
0.859 | -0.105 | 1 | 0.807 |
DAPK3 |
0.859 | 0.009 | -3 | 0.718 |
AAK1 |
0.857 | -0.001 | 1 | 0.567 |
SKMLCK |
0.857 | 0.095 | -2 | 0.900 |
SMMLCK |
0.857 | -0.040 | -3 | 0.737 |
TGFBR1 |
0.856 | 0.007 | -2 | 0.801 |
P38G |
0.856 | 0.282 | 1 | 0.694 |
ERK5 |
0.856 | 0.158 | 1 | 0.850 |
PASK |
0.855 | -0.089 | -3 | 0.777 |
NEK9 |
0.855 | -0.006 | 2 | 0.865 |
CDK5 |
0.854 | 0.294 | 1 | 0.822 |
CHAK2 |
0.854 | 0.095 | -1 | 0.877 |
BMPR1B |
0.854 | 0.066 | 1 | 0.782 |
MEKK3 |
0.853 | -0.236 | 1 | 0.813 |
TLK2 |
0.852 | -0.033 | 1 | 0.834 |
HRI |
0.851 | -0.141 | -2 | 0.870 |
CLK3 |
0.851 | 0.295 | 1 | 0.930 |
ERK2 |
0.851 | 0.213 | 1 | 0.797 |
NEK2 |
0.851 | 0.008 | 2 | 0.845 |
TSSK2 |
0.851 | 0.054 | -5 | 0.832 |
TAO1 |
0.851 | -0.069 | 1 | 0.744 |
PERK |
0.851 | -0.149 | -2 | 0.840 |
RAF1 |
0.850 | -0.144 | 1 | 0.831 |
P38D |
0.850 | 0.286 | 1 | 0.709 |
ACVR2B |
0.850 | -0.029 | -2 | 0.809 |
IRAK4 |
0.850 | -0.009 | 1 | 0.811 |
MLK1 |
0.850 | -0.048 | 2 | 0.850 |
HIPK1 |
0.849 | 0.211 | 1 | 0.845 |
COT |
0.849 | 0.114 | 2 | 0.894 |
PLK1 |
0.847 | -0.069 | -2 | 0.840 |
JNK1 |
0.847 | 0.236 | 1 | 0.744 |
ACVR2A |
0.847 | -0.057 | -2 | 0.797 |
PINK1 |
0.846 | -0.036 | 1 | 0.887 |
PKCD |
0.846 | 0.088 | 2 | 0.824 |
CDK1 |
0.845 | 0.263 | 1 | 0.771 |
WNK1 |
0.845 | 0.018 | -2 | 0.899 |
WNK4 |
0.845 | -0.117 | -2 | 0.887 |
ERK1 |
0.845 | 0.250 | 1 | 0.749 |
BUB1 |
0.845 | 0.069 | -5 | 0.752 |
ERK7 |
0.845 | 0.132 | 2 | 0.573 |
ROCK1 |
0.845 | 0.024 | -3 | 0.679 |
CAMK2G |
0.845 | -0.097 | 2 | 0.830 |
DAPK1 |
0.844 | -0.018 | -3 | 0.690 |
SLK |
0.844 | -0.095 | -2 | 0.738 |
TLK1 |
0.844 | -0.133 | -2 | 0.849 |
NEK3 |
0.843 | -0.100 | 1 | 0.780 |
MLK3 |
0.843 | 0.028 | 2 | 0.786 |
PIM3 |
0.843 | 0.042 | -3 | 0.766 |
DYRK2 |
0.843 | 0.226 | 1 | 0.834 |
PDHK4 |
0.843 | -0.291 | 1 | 0.867 |
CHAK1 |
0.843 | -0.010 | 2 | 0.813 |
PIM1 |
0.842 | 0.037 | -3 | 0.704 |
AMPKA1 |
0.842 | -0.011 | -3 | 0.795 |
PKN3 |
0.842 | -0.034 | -3 | 0.761 |
MLK4 |
0.842 | -0.024 | 2 | 0.757 |
CDK6 |
0.842 | 0.248 | 1 | 0.755 |
PDHK1 |
0.841 | -0.214 | 1 | 0.851 |
MAK |
0.841 | 0.172 | -2 | 0.762 |
CDK4 |
0.841 | 0.249 | 1 | 0.752 |
MASTL |
0.841 | -0.293 | -2 | 0.847 |
DSTYK |
0.841 | -0.002 | 2 | 0.905 |
RIPK3 |
0.841 | -0.037 | 3 | 0.747 |
TSSK1 |
0.841 | 0.059 | -3 | 0.817 |
CDKL5 |
0.841 | 0.056 | -3 | 0.717 |
HASPIN |
0.841 | -0.003 | -1 | 0.696 |
SMG1 |
0.840 | 0.088 | 1 | 0.808 |
DCAMKL1 |
0.840 | -0.047 | -3 | 0.717 |
BMPR1A |
0.840 | 0.015 | 1 | 0.770 |
GRK5 |
0.840 | -0.196 | -3 | 0.789 |
RIPK1 |
0.840 | -0.192 | 1 | 0.816 |
MRCKB |
0.840 | 0.037 | -3 | 0.661 |
GRK6 |
0.840 | -0.116 | 1 | 0.836 |
MST4 |
0.839 | 0.061 | 2 | 0.879 |
HIPK3 |
0.839 | 0.176 | 1 | 0.830 |
CDK2 |
0.839 | 0.187 | 1 | 0.831 |
PKN2 |
0.839 | 0.012 | -3 | 0.771 |
NUAK2 |
0.839 | 0.002 | -3 | 0.761 |
DYRK1A |
0.839 | 0.153 | 1 | 0.865 |
PIM2 |
0.838 | 0.009 | -3 | 0.665 |
ULK2 |
0.838 | -0.017 | 2 | 0.818 |
MOK |
0.838 | 0.128 | 1 | 0.827 |
MRCKA |
0.838 | 0.016 | -3 | 0.681 |
CLK4 |
0.838 | 0.154 | -3 | 0.672 |
CHK1 |
0.838 | -0.071 | -3 | 0.801 |
HUNK |
0.838 | -0.086 | 2 | 0.851 |
CDK14 |
0.837 | 0.220 | 1 | 0.774 |
P70S6KB |
0.837 | -0.009 | -3 | 0.723 |
HIPK4 |
0.837 | 0.181 | 1 | 0.898 |
MARK4 |
0.836 | -0.001 | 4 | 0.853 |
NEK7 |
0.836 | -0.067 | -3 | 0.809 |
CDC7 |
0.836 | -0.012 | 1 | 0.842 |
GRK7 |
0.836 | -0.027 | 1 | 0.777 |
CDK3 |
0.836 | 0.277 | 1 | 0.713 |
MTOR |
0.836 | -0.047 | 1 | 0.831 |
IRE1 |
0.834 | -0.004 | 1 | 0.814 |
TGFBR2 |
0.834 | -0.019 | -2 | 0.802 |
DNAPK |
0.834 | -0.008 | 1 | 0.708 |
NEK6 |
0.834 | 0.030 | -2 | 0.886 |
WNK3 |
0.833 | -0.156 | 1 | 0.824 |
CDK8 |
0.833 | 0.249 | 1 | 0.820 |
SGK3 |
0.833 | 0.026 | -3 | 0.691 |
CDK13 |
0.833 | 0.237 | 1 | 0.783 |
SRPK1 |
0.833 | 0.159 | -3 | 0.662 |
IRE2 |
0.833 | 0.003 | 2 | 0.781 |
DRAK1 |
0.833 | -0.101 | 1 | 0.735 |
CDK17 |
0.833 | 0.250 | 1 | 0.699 |
CDK18 |
0.833 | 0.277 | 1 | 0.743 |
CDK16 |
0.832 | 0.263 | 1 | 0.714 |
PLK3 |
0.832 | -0.098 | 2 | 0.797 |
CDK7 |
0.832 | 0.242 | 1 | 0.810 |
DCAMKL2 |
0.832 | -0.091 | -3 | 0.738 |
CRIK |
0.832 | -0.031 | -3 | 0.630 |
PKCZ |
0.832 | 0.031 | 2 | 0.813 |
ATM |
0.831 | -0.011 | 1 | 0.791 |
PKCA |
0.831 | 0.064 | 2 | 0.771 |
PAK1 |
0.830 | 0.044 | -2 | 0.834 |
CDK12 |
0.830 | 0.238 | 1 | 0.761 |
TBK1 |
0.830 | -0.097 | 1 | 0.722 |
DYRK3 |
0.830 | 0.164 | 1 | 0.847 |
MYLK4 |
0.830 | 0.006 | -2 | 0.824 |
CLK1 |
0.830 | 0.182 | -3 | 0.655 |
DYRK1B |
0.830 | 0.185 | 1 | 0.790 |
AMPKA2 |
0.830 | -0.022 | -3 | 0.763 |
SRPK3 |
0.829 | 0.083 | -3 | 0.626 |
PKCB |
0.829 | 0.077 | 2 | 0.776 |
PKCH |
0.829 | 0.009 | 2 | 0.766 |
PAK2 |
0.828 | -0.024 | -2 | 0.818 |
GSK3A |
0.828 | 0.050 | 4 | 0.416 |
CAMK2D |
0.828 | -0.068 | -3 | 0.784 |
CDK9 |
0.828 | 0.215 | 1 | 0.786 |
IRAK1 |
0.828 | -0.235 | -1 | 0.801 |
PAK3 |
0.827 | 0.031 | -2 | 0.835 |
SSTK |
0.827 | 0.040 | 4 | 0.836 |
MELK |
0.827 | -0.042 | -3 | 0.746 |
AKT2 |
0.827 | 0.013 | -3 | 0.596 |
GSK3B |
0.826 | -0.035 | 4 | 0.408 |
HIPK2 |
0.826 | 0.241 | 1 | 0.758 |
RSK2 |
0.826 | 0.034 | -3 | 0.693 |
MAPKAPK3 |
0.825 | -0.010 | -3 | 0.722 |
IKKE |
0.824 | -0.105 | 1 | 0.717 |
DYRK4 |
0.824 | 0.224 | 1 | 0.772 |
P90RSK |
0.824 | -0.010 | -3 | 0.697 |
TTBK2 |
0.824 | -0.163 | 2 | 0.746 |
GRK2 |
0.823 | -0.142 | -2 | 0.733 |
PRKD1 |
0.823 | 0.097 | -3 | 0.770 |
PKCG |
0.822 | 0.031 | 2 | 0.785 |
CDK10 |
0.822 | 0.239 | 1 | 0.761 |
PRKD3 |
0.821 | -0.008 | -3 | 0.657 |
CAMK4 |
0.821 | -0.132 | -3 | 0.748 |
AURB |
0.821 | 0.068 | -2 | 0.707 |
STK33 |
0.820 | -0.118 | 2 | 0.666 |
NDR1 |
0.820 | -0.035 | -3 | 0.776 |
SGK1 |
0.820 | -0.006 | -3 | 0.520 |
PKG2 |
0.820 | 0.082 | -2 | 0.717 |
MARK2 |
0.820 | -0.038 | 4 | 0.763 |
CHK2 |
0.819 | -0.071 | -3 | 0.542 |
AKT1 |
0.819 | 0.023 | -3 | 0.624 |
CAMK2B |
0.819 | -0.023 | 2 | 0.790 |
QIK |
0.819 | -0.118 | -3 | 0.762 |
ULK1 |
0.819 | -0.124 | -3 | 0.800 |
RIPK2 |
0.819 | -0.266 | 1 | 0.753 |
CDK19 |
0.819 | 0.244 | 1 | 0.782 |
RSK3 |
0.818 | 0.020 | -3 | 0.688 |
CAMK1D |
0.818 | -0.077 | -3 | 0.604 |
MNK2 |
0.818 | 0.084 | -2 | 0.840 |
PKCE |
0.818 | 0.034 | 2 | 0.772 |
GRK1 |
0.818 | -0.017 | -2 | 0.790 |
NIM1 |
0.817 | -0.092 | 3 | 0.797 |
PKCT |
0.817 | 0.012 | 2 | 0.768 |
PLK4 |
0.817 | -0.077 | 2 | 0.666 |
PRKD2 |
0.816 | 0.077 | -3 | 0.719 |
IKKB |
0.816 | -0.123 | -2 | 0.782 |
CAMK2A |
0.816 | -0.028 | 2 | 0.816 |
PDHK3_TYR |
0.816 | 0.196 | 4 | 0.890 |
PKCI |
0.816 | -0.006 | 2 | 0.784 |
QSK |
0.816 | -0.025 | 4 | 0.828 |
MNK1 |
0.815 | 0.040 | -2 | 0.846 |
CLK2 |
0.815 | 0.210 | -3 | 0.660 |
PKACG |
0.814 | 0.009 | -2 | 0.784 |
CAMK1G |
0.814 | -0.094 | -3 | 0.675 |
GCN2 |
0.814 | -0.153 | 2 | 0.831 |
MARK3 |
0.814 | -0.024 | 4 | 0.786 |
PLK2 |
0.814 | -0.081 | -3 | 0.740 |
SRPK2 |
0.813 | 0.115 | -3 | 0.583 |
GRK4 |
0.813 | -0.202 | -2 | 0.841 |
IKKA |
0.813 | -0.021 | -2 | 0.772 |
MARK1 |
0.813 | -0.090 | 4 | 0.805 |
MSK1 |
0.812 | 0.002 | -3 | 0.671 |
AURA |
0.811 | 0.051 | -2 | 0.688 |
RSK4 |
0.811 | 0.017 | -3 | 0.665 |
LATS2 |
0.809 | -0.043 | -5 | 0.748 |
AURC |
0.809 | 0.112 | -2 | 0.705 |
MSK2 |
0.809 | -0.055 | -3 | 0.656 |
BCKDK |
0.809 | -0.154 | -1 | 0.815 |
NUAK1 |
0.809 | -0.057 | -3 | 0.724 |
LIMK2_TYR |
0.808 | 0.142 | -3 | 0.865 |
NDR2 |
0.807 | -0.016 | -3 | 0.789 |
TESK1_TYR |
0.806 | -0.035 | 3 | 0.901 |
MAPKAPK2 |
0.806 | -0.004 | -3 | 0.675 |
PKACB |
0.806 | 0.063 | -2 | 0.725 |
SBK |
0.806 | -0.045 | -3 | 0.485 |
PHKG1 |
0.806 | -0.057 | -3 | 0.762 |
CAMK1A |
0.805 | -0.065 | -3 | 0.574 |
P70S6K |
0.805 | -0.074 | -3 | 0.628 |
PDHK4_TYR |
0.804 | -0.026 | 2 | 0.894 |
SIK |
0.803 | -0.066 | -3 | 0.687 |
PKMYT1_TYR |
0.803 | -0.037 | 3 | 0.862 |
MAP2K4_TYR |
0.803 | -0.117 | -1 | 0.894 |
MAP2K7_TYR |
0.802 | -0.185 | 2 | 0.883 |
MAP2K6_TYR |
0.802 | -0.094 | -1 | 0.891 |
EPHA6 |
0.801 | 0.073 | -1 | 0.883 |
PAK6 |
0.801 | 0.090 | -2 | 0.763 |
BMPR2_TYR |
0.800 | -0.066 | -1 | 0.861 |
SNRK |
0.799 | -0.187 | 2 | 0.710 |
TTBK1 |
0.798 | -0.175 | 2 | 0.670 |
PDHK1_TYR |
0.798 | -0.133 | -1 | 0.903 |
EPHB4 |
0.798 | 0.055 | -1 | 0.893 |
PKN1 |
0.798 | -0.051 | -3 | 0.640 |
LIMK1_TYR |
0.798 | -0.082 | 2 | 0.879 |
RET |
0.798 | -0.052 | 1 | 0.825 |
PINK1_TYR |
0.797 | -0.221 | 1 | 0.861 |
AKT3 |
0.797 | 0.010 | -3 | 0.537 |
TYRO3 |
0.795 | -0.007 | 3 | 0.808 |
PKACA |
0.795 | 0.030 | -2 | 0.672 |
DDR1 |
0.795 | -0.053 | 4 | 0.843 |
ROS1 |
0.795 | -0.007 | 3 | 0.782 |
MAPKAPK5 |
0.795 | -0.145 | -3 | 0.642 |
BRSK2 |
0.794 | -0.112 | -3 | 0.754 |
MST1R |
0.794 | -0.077 | 3 | 0.815 |
BRSK1 |
0.793 | -0.077 | -3 | 0.721 |
TXK |
0.793 | 0.104 | 1 | 0.823 |
TYK2 |
0.793 | -0.121 | 1 | 0.816 |
CSF1R |
0.792 | -0.036 | 3 | 0.794 |
GRK3 |
0.792 | -0.142 | -2 | 0.683 |
FAM20C |
0.792 | 0.054 | 2 | 0.622 |
KIS |
0.792 | 0.206 | 1 | 0.825 |
CK2A2 |
0.792 | 0.009 | 1 | 0.698 |
CK1D |
0.792 | -0.126 | -3 | 0.372 |
TNNI3K_TYR |
0.791 | 0.107 | 1 | 0.865 |
YES1 |
0.791 | -0.018 | -1 | 0.889 |
JAK2 |
0.791 | -0.097 | 1 | 0.821 |
ITK |
0.790 | 0.048 | -1 | 0.857 |
PHKG2 |
0.790 | -0.067 | -3 | 0.721 |
ABL2 |
0.790 | -0.006 | -1 | 0.868 |
TNK2 |
0.789 | 0.023 | 3 | 0.754 |
FER |
0.787 | -0.111 | 1 | 0.858 |
ABL1 |
0.787 | -0.021 | -1 | 0.863 |
JAK3 |
0.786 | -0.111 | 1 | 0.814 |
EPHB1 |
0.786 | -0.028 | 1 | 0.842 |
HCK |
0.786 | -0.041 | -1 | 0.865 |
CK1A2 |
0.786 | -0.126 | -3 | 0.365 |
SRMS |
0.785 | -0.049 | 1 | 0.839 |
PAK5 |
0.785 | 0.026 | -2 | 0.698 |
EPHB2 |
0.785 | -0.005 | -1 | 0.876 |
EPHB3 |
0.784 | -0.027 | -1 | 0.881 |
BMX |
0.784 | 0.041 | -1 | 0.810 |
FGR |
0.784 | -0.144 | 1 | 0.829 |
CK1E |
0.784 | -0.116 | -3 | 0.421 |
LCK |
0.784 | -0.000 | -1 | 0.858 |
PDGFRB |
0.784 | -0.113 | 3 | 0.815 |
EPHA4 |
0.783 | -0.069 | 2 | 0.799 |
TNK1 |
0.783 | -0.042 | 3 | 0.785 |
BLK |
0.783 | 0.019 | -1 | 0.861 |
YANK3 |
0.783 | -0.122 | 2 | 0.439 |
FGFR2 |
0.783 | -0.128 | 3 | 0.804 |
MERTK |
0.783 | 0.003 | 3 | 0.775 |
KDR |
0.782 | -0.086 | 3 | 0.766 |
AXL |
0.782 | -0.043 | 3 | 0.770 |
JAK1 |
0.782 | -0.017 | 1 | 0.757 |
TEK |
0.782 | -0.069 | 3 | 0.743 |
TEC |
0.782 | 0.009 | -1 | 0.832 |
INSRR |
0.782 | -0.135 | 3 | 0.760 |
CK2A1 |
0.782 | -0.015 | 1 | 0.675 |
KIT |
0.782 | -0.121 | 3 | 0.798 |
BTK |
0.781 | -0.055 | -1 | 0.845 |
NEK10_TYR |
0.781 | -0.097 | 1 | 0.689 |
FLT3 |
0.781 | -0.124 | 3 | 0.809 |
FGFR1 |
0.780 | -0.117 | 3 | 0.772 |
WEE1_TYR |
0.780 | -0.045 | -1 | 0.819 |
PRKX |
0.780 | 0.043 | -3 | 0.601 |
MET |
0.779 | -0.097 | 3 | 0.781 |
DDR2 |
0.778 | 0.029 | 3 | 0.746 |
ALK |
0.777 | -0.088 | 3 | 0.732 |
EPHA7 |
0.777 | -0.040 | 2 | 0.804 |
LTK |
0.776 | -0.084 | 3 | 0.753 |
PDGFRA |
0.776 | -0.183 | 3 | 0.810 |
PAK4 |
0.776 | 0.037 | -2 | 0.709 |
EPHA1 |
0.776 | -0.033 | 3 | 0.766 |
PTK6 |
0.774 | -0.164 | -1 | 0.804 |
FRK |
0.774 | -0.058 | -1 | 0.884 |
PTK2B |
0.773 | -0.018 | -1 | 0.854 |
EPHA3 |
0.772 | -0.127 | 2 | 0.772 |
YANK2 |
0.772 | -0.154 | 2 | 0.458 |
PKG1 |
0.771 | -0.003 | -2 | 0.626 |
FGFR3 |
0.771 | -0.160 | 3 | 0.776 |
FYN |
0.770 | -0.068 | -1 | 0.825 |
NTRK1 |
0.769 | -0.225 | -1 | 0.864 |
INSR |
0.769 | -0.159 | 3 | 0.732 |
NTRK2 |
0.769 | -0.194 | 3 | 0.752 |
FLT1 |
0.769 | -0.188 | -1 | 0.835 |
LYN |
0.768 | -0.103 | 3 | 0.717 |
ERBB2 |
0.768 | -0.207 | 1 | 0.780 |
MATK |
0.768 | -0.117 | -1 | 0.804 |
FLT4 |
0.767 | -0.211 | 3 | 0.760 |
NTRK3 |
0.766 | -0.137 | -1 | 0.827 |
EPHA5 |
0.766 | -0.090 | 2 | 0.779 |
EPHA8 |
0.764 | -0.109 | -1 | 0.845 |
SRC |
0.763 | -0.116 | -1 | 0.838 |
EGFR |
0.762 | -0.108 | 1 | 0.700 |
CSK |
0.761 | -0.161 | 2 | 0.808 |
MUSK |
0.759 | -0.113 | 1 | 0.673 |
FGFR4 |
0.757 | -0.139 | -1 | 0.825 |
CK1G1 |
0.755 | -0.132 | -3 | 0.416 |
EPHA2 |
0.755 | -0.110 | -1 | 0.813 |
PTK2 |
0.753 | -0.095 | -1 | 0.758 |
SYK |
0.750 | -0.125 | -1 | 0.774 |
IGF1R |
0.748 | -0.205 | 3 | 0.669 |
ERBB4 |
0.745 | -0.129 | 1 | 0.706 |
CK1G3 |
0.743 | -0.148 | -3 | 0.232 |
FES |
0.743 | -0.134 | -1 | 0.788 |
ZAP70 |
0.730 | -0.111 | -1 | 0.719 |
CK1A |
0.717 | -0.151 | -3 | 0.280 |
CK1G2 |
0.715 | -0.162 | -3 | 0.331 |