Motif 1091 (n=261)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0U1RQJ8 | ATRIP | T336 | ochoa | ATR interacting protein | None |
| A0A1W2PNV4 | None | T647 | ochoa | Actin-related protein 2/3 complex subunit 1A | None |
| C9JH25 | PRRT4 | T717 | ochoa | Proline-rich transmembrane protein 4 | None |
| O00151 | PDLIM1 | T141 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00192 | ARVCF | T286 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O00192 | ARVCF | T322 | ochoa | Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome) | Contributes to the regulation of alternative splicing of pre-mRNAs. {ECO:0000269|PubMed:24644279}. |
| O15084 | ANKRD28 | T982 | ochoa | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) | Regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Involved in the PP6-mediated dephosphorylation of MOB1 and induced focal adhesion assembly during cell migration (PubMed:35512830). {ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651, ECO:0000269|PubMed:35512830}. |
| O15143 | ARPC1B | T315 | ochoa | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| O43182 | ARHGAP6 | T821 | ochoa | Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269|PubMed:10699171}. |
| O43312 | MTSS1 | T588 | ochoa | Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein) | May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton. |
| O60503 | ADCY9 | T662 | ochoa | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. |
| O60701 | UGDH | T93 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O75369 | FLNB | T1400 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75385 | ULK1 | T746 | ochoa | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PubMed:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PubMed:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PubMed:11146101). Also phosphorylates SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165, PubMed:37306101). Phosphorylates FLCN, promoting autophagy (PubMed:25126726). Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation (PubMed:20921139). Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B (PubMed:28821708). {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:20921139, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:23524951, ECO:0000269|PubMed:25040165, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:28821708, ECO:0000269|PubMed:29487085, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:37306101}. |
| O75427 | LRCH4 | T19 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein) | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}. |
| O75534 | CSDE1 | T761 | ochoa | Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) | RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:15314026, ECO:0000269|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269|PubMed:10049359}. |
| O75822 | EIF3J | T33 | ochoa | Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| O95049 | TJP3 | T587 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95359 | TACC2 | T2716 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95810 | CAVIN2 | T360 | ochoa | Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein) | Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}. |
| O95817 | BAG3 | T144 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O95817 | BAG3 | T145 | ochoa | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27884606, ECO:0000269|PubMed:30559338, ECO:0000269|PubMed:9873016}. |
| O95831 | AIFM1 | T526 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| O95865 | DDAH2 | T203 | psp | Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein) | Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}. |
| P00519 | ABL1 | T1008 | ochoa | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 also acts as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}. |
| P04083 | ANXA1 | T216 | psp | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P04792 | HSPB1 | T91 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P05455 | SSB | T362 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P10412 | H1-4 | T45 | ochoa | Histone H1.4 (Histone H1b) (Histone H1s-4) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P10636 | MAPT | T30 | psp | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11142 | HSPA8 | T158 | ochoa | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P11171 | EPB41 | T565 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12318 | FCGR2A | T283 | ochoa | Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32) | Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269|PubMed:19011614}. |
| P12883 | MYH7 | T215 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12931 | SRC | T74 | ochoa | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P13164 | IFITM1 | T73 | ochoa | Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Interferon-induced protein 17) (Interferon-inducible protein 9-27) (Leu-13 antigen) (CD antigen CD225) | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927). Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876). Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:33270927}. |
| P13929 | ENO3 | T19 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P13929 | ENO3 | T229 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P14923 | JUP | T551 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P15153 | RAC2 | T161 | ochoa | Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2) | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:1660188). {ECO:0000269|PubMed:1660188, ECO:0000269|PubMed:30723080}. |
| P15559 | NQO1 | T128 | psp | NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) | Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity) (PubMed:8999809, PubMed:9271353). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (PubMed:15102952, PubMed:8999809, PubMed:9271353). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (PubMed:8999809). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255, PubMed:28291250). {ECO:0000250|UniProtKB:P05982, ECO:0000269|PubMed:15102952, ECO:0000269|PubMed:15687255, ECO:0000269|PubMed:28291250, ECO:0000269|PubMed:8999809, ECO:0000269|PubMed:9271353}. |
| P16402 | H1-3 | T46 | ochoa | Histone H1.3 (Histone H1c) (Histone H1s-2) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P16403 | H1-2 | T45 | ochoa | Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1) | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
| P20073 | ANXA7 | T286 | psp | Annexin A7 (Annexin VII) (Annexin-7) (Synexin) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. |
| P20719 | HOXA5 | T145 | ochoa | Homeobox protein Hox-A5 (Homeobox protein Hox-1C) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'. |
| P21980 | TGM2 | T162 | psp | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:23941696, PubMed:31991788, PubMed:9252372). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:27270573, PubMed:28198360, PubMed:7935379, PubMed:9252372). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:18092889, PubMed:7592956, PubMed:7649299). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:20547769, PubMed:9623982). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {ECO:0000250|UniProtKB:P08587, ECO:0000250|UniProtKB:P21981, ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874, ECO:0000269|PubMed:18092889, ECO:0000269|PubMed:20547769, ECO:0000269|PubMed:23797785, ECO:0000269|PubMed:23941696, ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:26250429, ECO:0000269|PubMed:27131890, ECO:0000269|PubMed:28198360, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:30458214, ECO:0000269|PubMed:30867594, ECO:0000269|PubMed:31991788, ECO:0000269|PubMed:32273471, ECO:0000269|PubMed:7592956, ECO:0000269|PubMed:7649299, ECO:0000269|PubMed:7935379, ECO:0000269|PubMed:8943303, ECO:0000269|PubMed:9252372, ECO:0000269|PubMed:9623982, ECO:0000303|PubMed:27270573}.; FUNCTION: [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {ECO:0000269|PubMed:17116873}. |
| P22102 | GART | T498 | ochoa | Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] | Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}. |
| P22695 | UQCRC2 | T369 | ochoa | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). {ECO:0000250|UniProtKB:P07257, ECO:0000250|UniProtKB:P23004, ECO:0000305|PubMed:29243944}. |
| P22736 | NR4A1 | T55 | psp | Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) | Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (PubMed:18690216). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (PubMed:22983157). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (PubMed:15466594). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). {ECO:0000250|UniProtKB:P12813, ECO:0000250|UniProtKB:P22829, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:18690216, ECO:0000269|PubMed:22983157, ECO:0000269|PubMed:8121493, ECO:0000269|PubMed:9315652}.; FUNCTION: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7. {ECO:0000250|UniProtKB:P12813}. |
| P23246 | SFPQ | T440 | ochoa | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as a transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). {ECO:0000250|UniProtKB:Q8VIJ6, ECO:0000269|PubMed:10847580, ECO:0000269|PubMed:10858305, ECO:0000269|PubMed:10931916, ECO:0000269|PubMed:11259580, ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:11897684, ECO:0000269|PubMed:15590677, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:25765647, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:8045264, ECO:0000269|PubMed:8449401}. |
| P25100 | ADRA1D | T328 | psp | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) | This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. |
| P25398 | RPS12 | T24 | ochoa | Small ribosomal subunit protein eS12 (40S ribosomal protein S12) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Subunit of the 40S ribosomal complex (By similarity). {ECO:0000250|UniProtKB:P80455, ECO:0000269|PubMed:34516797}. |
| P27448 | MARK3 | T564 | ochoa|psp | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P27816 | MAP4 | T811 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P29353 | SHC1 | T515 | ochoa | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269|PubMed:14665640}. |
| P30405 | PPIF | T158 | ochoa | Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691). {ECO:0000250|UniProtKB:Q99KR7, ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}. |
| P31629 | HIVEP2 | T1627 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P32926 | DSG3 | T768 | ochoa | Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450). {ECO:0000250|UniProtKB:O35902, ECO:0000269|PubMed:22294297, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31835537, ECO:0000269|PubMed:9701552}. |
| P35221 | CTNNA1 | T223 | ochoa | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| P35222 | CTNNB1 | T112 | psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35222 | CTNNB1 | T653 | ochoa|psp | Catenin beta-1 (Beta-catenin) | Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22187462, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:29910125}. |
| P35346 | SSTR5 | T247 | psp | Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) (SST5) | Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. {ECO:0000269|PubMed:12072395, ECO:0000269|PubMed:7908405, ECO:0000269|PubMed:8078491, ECO:0000269|PubMed:8373420}. |
| P35579 | MYH9 | T386 | ochoa | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35637 | FUS | T19 | psp | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:21256132, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. |
| P38646 | HSPA9 | T205 | ochoa | Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250|UniProtKB:P0CS90, ECO:0000250|UniProtKB:P38647, ECO:0000269|PubMed:16091382, ECO:0000269|PubMed:18632665, ECO:0000269|PubMed:21123823, ECO:0000269|PubMed:24625977, ECO:0000269|PubMed:25615450, ECO:0000269|PubMed:26634371, ECO:0000269|PubMed:26702583, ECO:0000269|PubMed:28848044, ECO:0000269|PubMed:30933555, ECO:0000269|PubMed:31177526}. |
| P40926 | MDH2 | T248 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P41240 | CSK | T23 | ochoa | Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL) | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}. |
| P42684 | ABL2 | T858 | ochoa | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250|UniProtKB:Q4JIM5, ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}. |
| P43364 | MAGEA11 | T360 | psp | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
| P48730 | CSNK1D | T176 | psp | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| P49821 | NDUFV1 | T383 | psp | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (NDUFV1) (EC 7.1.1.2) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit) | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:28844695). Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone (PubMed:28844695). Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster (PubMed:28844695). {ECO:0000269|PubMed:28844695}. |
| P49916 | LIG3 | T203 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P50395 | GDI2 | T205 | ochoa | Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| P51116 | FXR2 | T558 | ochoa | RNA-binding protein FXR2 (FXR2P) (FMR1 autosomal homolog 2) | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity). {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}. |
| P51151 | RAB9A | T175 | ochoa | Ras-related protein Rab-9A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN) (PubMed:34793709). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (PubMed:34793709). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:P24408, ECO:0000250|UniProtKB:P62820, ECO:0000269|PubMed:34793709}. |
| P51610 | HCFC1 | T405 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P51788 | CLCN2 | T20 | ochoa | Chloride channel protein 2 (ClC-2) | Voltage-gated and osmosensitive chloride channel. Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Displays inward rectification currents activated upon membrane hyperpolarization and extracellular hypotonicity (PubMed:16155254, PubMed:17567819, PubMed:19191339, PubMed:23632988, PubMed:29403011, PubMed:29403012, PubMed:36964785, PubMed:38345841). Contributes to chloride conductance involved in neuron excitability. In hippocampal neurons, generates a significant part of resting membrane conductance and provides an additional chloride efflux pathway to prevent chloride accumulation in dendrites upon GABA receptor activation. In glia, associates with the auxiliary subunit HEPACAM/GlialCAM at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux buffering extracellular chloride and potassium concentrations (PubMed:19191339, PubMed:22405205, PubMed:23707145). Regulates aldosterone production in adrenal glands. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated calcium channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). Contributes to chloride conductance in retinal pigment epithelium involved in phagocytosis of shed photoreceptor outer segments and photoreceptor renewal (PubMed:36964785). Conducts chloride currents at the basolateral membrane of epithelial cells with a role in chloride reabsorption rather than secretion (By similarity) (PubMed:16155254). Permeable to small monovalent anions with chloride > thiocyanate > bromide > nitrate > iodide ion selectivity (By similarity) (PubMed:29403012). {ECO:0000250|UniProtKB:P35525, ECO:0000250|UniProtKB:Q9R0A1, ECO:0000269|PubMed:16155254, ECO:0000269|PubMed:17567819, ECO:0000269|PubMed:19191339, ECO:0000269|PubMed:22405205, ECO:0000269|PubMed:23632988, ECO:0000269|PubMed:23707145, ECO:0000269|PubMed:29403011, ECO:0000269|PubMed:29403012, ECO:0000269|PubMed:36964785, ECO:0000269|PubMed:38345841}. |
| P54198 | HIRA | T542 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P54274 | TERF1 | T122 | psp | Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269|PubMed:16166375}. |
| P56524 | HDAC4 | T355 | ochoa | Histone deacetylase 4 (HD4) (EC 3.5.1.98) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}. |
| P56746 | CLDN15 | T210 | ochoa | Claudin-15 | Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:12055082, PubMed:13129853, PubMed:31188544, PubMed:35650657, PubMed:36008380). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q9Z0S5, ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853, ECO:0000269|PubMed:31188544, ECO:0000269|PubMed:35650657, ECO:0000269|PubMed:36008380}. |
| P60763 | RAC3 | T161 | ochoa | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}. |
| P63000 | RAC1 | T161 | ochoa | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles (PubMed:1643658, PubMed:22843693, PubMed:23512198, PubMed:28886345). Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts (PubMed:1643658). In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX (PubMed:12695502). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity). Required for DSG3 translocation to cell-cell junctions, DSG3-mediated organization of cortical F-actin bundles and anchoring of actin at cell junctions; via interaction with DSG3 (PubMed:22796473). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:38355798). {ECO:0000250|UniProtKB:P63001, ECO:0000250|UniProtKB:Q6RUV5, ECO:0000269|PubMed:12695502, ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:22796473, ECO:0000269|PubMed:22843693, ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:28886345, ECO:0000269|PubMed:38355798, ECO:0000269|PubMed:9121475}.; FUNCTION: [Isoform B]: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins (PubMed:14625275). It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction (PubMed:14625275). {ECO:0000269|PubMed:14625275}. |
| P78527 | PRKDC | T2647 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P78527 | PRKDC | T2649 | ochoa | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| P98172 | EFNB1 | T294 | ochoa | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7973638, PubMed:8070404). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:7973638, PubMed:8070404). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7973638, PubMed:8070404). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}. |
| Q00872 | MYBPC1 | T802 | ochoa | Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Q01628 | IFITM3 | T94 | ochoa | Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Interferon-inducible protein 1-8U) | IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33270927). Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). Exerts opposing activities on SARS-CoV-2, including amphipathicity-dependent restriction of virus at endosomes and amphipathicity-independent enhancement of infection at the plasma membrane (PubMed:33270927). {ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22046135, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:23601107, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927}. |
| Q01629 | IFITM2 | T93 | ochoa | Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D) | IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:26354436, PubMed:33563656). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927, PubMed:33563656). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927, ECO:0000269|PubMed:33563656}. |
| Q01650 | SLC7A5 | T45 | ochoa | Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter) | The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine (PubMed:10049700, PubMed:10574970, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:18262359, PubMed:25998567, PubMed:30867591, PubMed:9751058). The heterodimer with SLC3A2 mediates the uptake of L-DOPA (By similarity). Functions as an amino acid exchanger (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694). When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567). Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (PubMed:15769744). {ECO:0000250|UniProtKB:Q63016, ECO:0000250|UniProtKB:Q9Z127, ECO:0000269|PubMed:10049700, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:18262359, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:9751058, ECO:0000305|PubMed:18262359}.; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. {ECO:0000269|PubMed:30341327}. |
| Q02086 | SP2 | T27 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
| Q02447 | SP3 | T115 | ochoa | Transcription factor Sp3 (SPR-2) | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11812829, ECO:0000269|PubMed:12419227, ECO:0000269|PubMed:12837748, ECO:0000269|PubMed:15247228, ECO:0000269|PubMed:15494207, ECO:0000269|PubMed:15554904, ECO:0000269|PubMed:16781829, ECO:0000269|PubMed:17548428, ECO:0000269|PubMed:18187045, ECO:0000269|PubMed:18617891, ECO:0000269|PubMed:9278495}. |
| Q04206 | RELA | T435 | psp | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}. |
| Q04760 | GLO1 | T107 | psp | Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007). Required for normal osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CPU0, ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:20454679, ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294}. |
| Q07157 | TJP1 | T1167 | ochoa | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q12774 | ARHGEF5 | T971 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12906 | ILF3 | T315 | psp | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q12955 | ANK3 | T529 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13009 | TIAM1 | T340 | psp | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. {ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}. |
| Q13233 | MAP3K1 | T20 | ochoa | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27) | Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). {ECO:0000269|PubMed:17761173, ECO:0000269|PubMed:9808624}. |
| Q13263 | TRIM28 | T514 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13621 | SLC12A1 | T95 | psp | Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (BSC1) (Kidney-specific Na-K-Cl symporter) (Na-K-2Cl cotransporter 2) (NKCC2) | Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). Electrically silent transporter system (By similarity). {ECO:0000250|UniProtKB:P55014, ECO:0000250|UniProtKB:P55016, ECO:0000269|PubMed:21321328}. |
| Q13813 | SPTAN1 | T1184 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q13976 | PRKG1 | T515 | ochoa | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) | Serine/threonine protein kinase that acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways: phosphorylates IRAG1 and inhibits IP3-induced Ca(2+) release from intracellular stores, phosphorylation of KCNMA1 (BKCa) channels decreases intracellular Ca(2+) levels, which leads to increased opening of this channel. PRKG1 phosphorylates the canonical transient receptor potential channel (TRPC) family which inactivates the associated inward calcium current. Another mode of action of NO/cGMP/PKGI signaling involves PKGI-mediated inactivation of the Ras homolog gene family member A (RhoA). Phosphorylation of RHOA by PRKG1 blocks the action of this protein in myriad processes: regulation of RHOA translocation; decreasing contraction; controlling vesicle trafficking, reduction of myosin light chain phosphorylation resulting in vasorelaxation. Activation of PRKG1 by NO signaling also alters gene expression in a number of tissues. In smooth muscle cells, increased cGMP and PRKG1 activity influence expression of smooth muscle-specific contractile proteins, levels of proteins in the NO/cGMP signaling pathway, down-regulation of the matrix proteins osteopontin and thrombospondin-1 to limit smooth muscle cell migration and phenotype. Regulates vasodilator-stimulated phosphoprotein (VASP) functions in platelets and smooth muscle. {ECO:0000269|PubMed:10567269, ECO:0000269|PubMed:11162591, ECO:0000269|PubMed:11723116, ECO:0000269|PubMed:12082086, ECO:0000269|PubMed:14608379, ECO:0000269|PubMed:15194681, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:8182057}. |
| Q14135 | VGLL4 | T203 | ochoa | Transcription cofactor vestigial-like protein 4 (Vgl-4) | May act as a specific coactivator for the mammalian TEFs. {ECO:0000250}. |
| Q14194 | CRMP1 | T102 | psp | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). {ECO:0000269|PubMed:11562390, ECO:0000269|PubMed:19799413, ECO:0000269|PubMed:25358863}. |
| Q14247 | CTTN | T24 | ochoa | Src substrate cortactin (Amplaxin) (Oncogene EMS1) | Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. |
| Q14315 | FLNC | T2305 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14653 | IRF3 | T75 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14677 | CLINT1 | T284 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14677 | CLINT1 | T306 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q15149 | PLEC | T2886 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q15365 | PCBP1 | T88 | ochoa | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15629 | TRAM1 | T350 | ochoa | Translocating chain-associated membrane protein 1 (Protein TRAM1) | Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:12475939, PubMed:1315422, PubMed:32013668, PubMed:8616892, PubMed:9506517). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER (PubMed:9506517). May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport (PubMed:32013668). Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane (PubMed:8616892). Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane (PubMed:12475939). Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed:20430023). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:1315422, ECO:0000269|PubMed:20430023, ECO:0000269|PubMed:32013668, ECO:0000269|PubMed:8616892, ECO:0000269|PubMed:9506517, ECO:0000303|PubMed:32013668}.; FUNCTION: (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells. {ECO:0000269|PubMed:19121997}. |
| Q15811 | ITSN1 | T839 | psp | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250|UniProtKB:Q9WVE9, ECO:0000250|UniProtKB:Q9Z0R4, ECO:0000269|PubMed:11584276, ECO:0000269|PubMed:11744688, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250|UniProtKB:Q9Z0R4}. |
| Q15847 | ADIRF | T50 | ochoa | Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2) | Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin. {ECO:0000269|PubMed:19444912, ECO:0000269|PubMed:23239344}. |
| Q24JP5 | TMEM132A | T950 | ochoa | Transmembrane protein 132A (HSPA5-binding protein 1) | May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity). {ECO:0000250}. |
| Q27J81 | INF2 | T377 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q2NL68 | PROSER3 | T342 | ochoa | Proline and serine-rich protein 3 | None |
| Q2TAZ0 | ATG2A | T1641 | ochoa | Autophagy-related protein 2 homolog A | Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}. |
| Q32P44 | EML3 | T843 | ochoa | Echinoderm microtubule-associated protein-like 3 (EMAP-3) | Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269|PubMed:18445686, ECO:0000269|PubMed:30723163}. |
| Q5SW79 | CEP170 | T1134 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5SY16 | NOL9 | T492 | ochoa | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9) | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. |
| Q63HQ0 | AP1AR | T192 | ochoa | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269|PubMed:15775984, ECO:0000269|PubMed:19706427, ECO:0000269|PubMed:21525240, ECO:0000269|PubMed:22689987}. |
| Q69YQ0 | SPECC1L | T894 | ochoa | Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein) | Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269|PubMed:21703590}. |
| Q6BEB4 | SP5 | T20 | ochoa | Transcription factor Sp5 | Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity). {ECO:0000250}. |
| Q6DCA0 | AMMECR1L | T31 | ochoa | AMMECR1-like protein | None |
| Q6P1L5 | FAM117B | T111 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P2E9 | EDC4 | T594 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6ZMI0 | PPP1R21 | T648 | ochoa | Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (Ferry endosomal RAB5 effector complex subunit 2) (Fy-2) (KLRAQ motif-containing protein 1) | Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905, PubMed:37267906). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). In the complex, PPP1R21 serves as a binding hub connecting all five complex subunits and mediating the binding to mRNA and early endosomes via RAB5A (PubMed:37267906). Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (Probable) (PubMed:30520571). {ECO:0000269|PubMed:30520571, ECO:0000269|PubMed:37267905, ECO:0000269|PubMed:37267906, ECO:0000305|PubMed:19389623}. |
| Q6ZRV2 | FAM83H | T414 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZRV2 | FAM83H | T714 | ochoa | Protein FAM83H | May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269|PubMed:18252228, ECO:0000269|PubMed:23902688}. |
| Q6ZVM7 | TOM1L2 | T403 | ochoa | TOM1-like protein 2 (Target of Myb-like protein 2) | Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011). {ECO:0000269|PubMed:16412388, ECO:0000269|PubMed:16479011, ECO:0000269|PubMed:23023224}. |
| Q7Z3B3 | KANSL1 | T28 | ochoa | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:26243146, ECO:0000269|PubMed:27768893, ECO:0000269|PubMed:33657400}. |
| Q7Z4S6 | KIF21A | T862 | ochoa | Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) | Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. {ECO:0000250|UniProtKB:Q9QXL2, ECO:0000269|PubMed:24120883}. |
| Q7Z6Z7 | HUWE1 | T2540 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86U86 | PBRM1 | T377 | ochoa | Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. {ECO:0000269|PubMed:21248752, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q86UU1 | PHLDB1 | T643 | ochoa | Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) | None |
| Q86XN8 | MEX3D | T274 | ochoa | RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. |
| Q8IU81 | IRF2BP1 | T496 | ochoa | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:18671972}. |
| Q8IVT2 | MISP | T160 | ochoa | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}. |
| Q8N122 | RPTOR | T908 | psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N2K0 | ABHD12 | T43 | ochoa | Lysophosphatidylserine lipase ABHD12 (EC 3.1.-.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (hABHD12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-) | Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30643283, PubMed:30720278). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283). Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063). Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167). {ECO:0000250|UniProtKB:Q99LR1, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24027063, ECO:0000269|PubMed:25290914, ECO:0000269|PubMed:30237167, ECO:0000269|PubMed:30420694, ECO:0000269|PubMed:30643283, ECO:0000269|PubMed:30720278}. |
| Q8N4X5 | AFAP1L2 | T488 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8NDI1 | EHBP1 | T165 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8TAD7 | OCC1 | T30 | ochoa | Overexpressed in colon carcinoma 1 protein (OCC-1) (AGD3) | None |
| Q8TAE6 | PPP1R14C | T73 | psp | Protein phosphatase 1 regulatory subunit 14C (Kinase-enhanced PP1 inhibitor) (PKC-potentiated PP1 inhibitory protein) (Serologically defined breast cancer antigen NY-BR-81) | Inhibitor of the PP1 regulatory subunit PPP1CA. |
| Q8TDQ1 | CD300LF | T221 | psp | CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f) | Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity). {ECO:0000250|UniProtKB:Q6SJQ7, ECO:0000269|PubMed:15549731, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:24035150}. |
| Q8WUA7 | TBC1D22A | T173 | ochoa | TBC1 domain family member 22A | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000250}. |
| Q8WWH5 | TRUB1 | T24 | ochoa | Pseudouridylate synthase TRUB1 (EC 5.4.99.-) (TruB pseudouridine synthase homolog 1) (tRNA pseudouridine 55 synthase TRUB1) (Psi55 synthase TRUB1) (EC 5.4.99.25) | Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs (PubMed:28073919, PubMed:31477916, PubMed:32926445). Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure (PubMed:28073919, PubMed:31477916). Constitutes the major pseudouridine synthase acting on mRNAs (PubMed:28073919). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:32926445, PubMed:33023933). Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity (PubMed:32926445). Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation (PubMed:32926445). {ECO:0000269|PubMed:28073919, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:32926445, ECO:0000269|PubMed:33023933}. |
| Q8WXE1 | ATRIP | T56 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WXE1 | ATRIP | T523 | ochoa | ATR-interacting protein (ATM and Rad3-related-interacting protein) | Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}. |
| Q8WYL5 | SSH1 | T747 | ochoa | Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L) | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}. |
| Q8WYP5 | AHCTF1 | T1407 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92619 | ARHGAP45 | T600 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92692 | NECTIN2 | T390 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q92692 | NECTIN2 | T459 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q92800 | EZH1 | T392 | ochoa | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026781}. |
| Q92918 | MAP4K1 | T349 | psp | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q92945 | KHSRP | T94 | ochoa | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Q969E2 | SCAMP4 | T194 | ochoa | Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4) | Probably involved in membrane protein trafficking. {ECO:0000250}. |
| Q96DE5 | ANAPC16 | T19 | ochoa | Anaphase-promoting complex subunit 16 (APC16) (Cyclosome subunit 16) | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:20360068). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20360068). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:29033132}. |
| Q96I24 | FUBP3 | T544 | ochoa | Far upstream element-binding protein 3 (FUSE-binding protein 3) | May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. |
| Q96IQ7 | VSIG2 | T277 | ochoa | V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein) | None |
| Q96K21 | ZFYVE19 | T345 | ochoa | Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) | Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}. |
| Q96T51 | RUFY1 | T74 | ochoa | RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12) | Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}. |
| Q99714 | HSD17B10 | T66 | ochoa | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:10600649, PubMed:12917011, PubMed:18996107, PubMed:19706438, PubMed:20077426, PubMed:25925575, PubMed:26950678, PubMed:28888424, PubMed:9553139). Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA (PubMed:10600649, PubMed:12917011, PubMed:25925575, PubMed:26950678, PubMed:9553139). Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway (PubMed:18996107, PubMed:19706438, PubMed:20077426). Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids (PubMed:10600649, PubMed:12917011). Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel (PubMed:19706438, PubMed:28888424). Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis (PubMed:26338420). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). {ECO:0000269|PubMed:10600649, ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18996107, ECO:0000269|PubMed:19706438, ECO:0000269|PubMed:20077426, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26338420, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:9553139}.; FUNCTION: In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424). Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24549042, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:29040705}. |
| Q99728 | BARD1 | T714 | psp | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:20351172}. |
| Q99959 | PKP2 | T334 | ochoa | Plakophilin-2 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297). {ECO:0000250|UniProtKB:F1M7L9, ECO:0000250|UniProtKB:Q9CQ73, ECO:0000269|PubMed:18662195, ECO:0000269|PubMed:20613778, ECO:0000269|PubMed:22781308, ECO:0000269|PubMed:23884246, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:28169297, ECO:0000269|PubMed:34368962, ECO:0000269|PubMed:35959657}. |
| Q9BQ61 | TRIR | T112 | ochoa | Telomerase RNA component interacting RNase (EC 3.1.13.-) (Exoribonuclease TRIR) | Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to cleave all four unpaired RNA nucleotides from the 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335). {ECO:0000269|PubMed:28322335}. |
| Q9BRP8 | PYM1 | T19 | ochoa | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}. |
| Q9BT23 | LIMD2 | T23 | ochoa | LIM domain-containing protein 2 | Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809). {ECO:0000269|PubMed:24590809}. |
| Q9BXB5 | OSBPL10 | T217 | ochoa | Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10) | Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000305}. |
| Q9BY89 | KIAA1671 | T1031 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0B1 | FTO | T150 | psp | Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:28002401, PubMed:30197295). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:25452335, PubMed:26457839, PubMed:26458103, PubMed:30197295). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}. |
| Q9C0D5 | TANC1 | T1587 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9GZV5 | WWTR1 | T21 | ochoa | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151, PubMed:23911299). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018). {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321, ECO:0000269|PubMed:23911299}. |
| Q9H0E3 | SAP130 | T305 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H0K1 | SIK2 | T484 | ochoa|psp | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H3P2 | NELFA | T150 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H3S7 | PTPN23 | T1131 | ochoa | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}. |
| Q9H4A3 | WNK1 | T2245 | ochoa | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| Q9HAP2 | MLXIP | T632 | ochoa | MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) | Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Q9HCC9 | ZFYVE28 | T516 | ochoa | Lateral signaling target protein 2 homolog (hLst2) (Zinc finger FYVE domain-containing protein 28) | Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. {ECO:0000269|PubMed:19460345}. |
| Q9NNW5 | WDR6 | T555 | ochoa | tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6) | Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Required for the correct positioning of the substrate tRNA for methylation (PubMed:32558197). Required to suppress amino acid starvation-induced autophagy (PubMed:22354037). Enhances the STK11/LKB1-induced cell growth suppression activity (PubMed:17216128). {ECO:0000269|PubMed:17216128, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871}. |
| Q9NR12 | PDLIM7 | T62 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NR12 | PDLIM7 | T279 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NXG6 | P4HTM | T483 | ochoa | Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. {ECO:0000269|PubMed:17726031}. |
| Q9P0K7 | RAI14 | T672 | ochoa | Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) | Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250|UniProtKB:Q5U312}. |
| Q9UBM7 | DHCR7 | T19 | ochoa | 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Cholesterol-5,6-epoxide hydrolase subunit DHCR7) (EC 3.3.2.11) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2) | Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (PubMed:25637936, PubMed:38297129, PubMed:38297130, PubMed:9465114, PubMed:9634533). Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (By similarity). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation (PubMed:38297129, PubMed:38297130). {ECO:0000250|UniProtKB:O88455, ECO:0000269|PubMed:25637936, ECO:0000269|PubMed:38297129, ECO:0000269|PubMed:38297130, ECO:0000269|PubMed:9465114, ECO:0000269|PubMed:9634533}.; FUNCTION: Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between cholestenol Delta-isomerase/EBP and DHCR7 (PubMed:15175332, PubMed:20615952). This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT) (PubMed:20615952). The precise role of each component of this complex has not been described yet (PubMed:20615952). {ECO:0000269|PubMed:15175332, ECO:0000269|PubMed:20615952}. |
| Q9UGY1 | NOL12 | T145 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
| Q9UKD1 | GMEB2 | T377 | ochoa | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| Q9UMN6 | KMT2B | T2068 | ochoa | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17707229, PubMed:25561738). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (PubMed:24081332). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q9UMY4 | SNX12 | T20 | ochoa | Sorting nexin-12 | May be involved in several stages of intracellular trafficking. {ECO:0000250}. |
| Q9UNF0 | PACSIN2 | T321 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| Q9UPN9 | TRIM33 | T1085 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UQ35 | SRRM2 | T2252 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T2291 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQ35 | SRRM2 | T2347 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y261 | FOXA2 | T297 | ochoa | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Transcription factor 3B) (TCF-3B) | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}. |
| Q9Y2F5 | ICE1 | T1720 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y3B9 | RRP15 | T19 | ochoa | RRP15-like protein (Ribosomal RNA-processing protein 15) | None |
| Q9Y4A5 | TRRAP | T1622 | ochoa | Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) | Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity). {ECO:0000250|UniProtKB:A0A0R4ITC5, ECO:0000269|PubMed:11418595, ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246, ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511, ECO:0000269|PubMed:9708738}. |
| Q9Y4B5 | MTCL1 | T1757 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4H2 | IRS2 | T599 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
| Q9Y666 | SLC12A7 | T980 | ochoa|psp | Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}. |
| Q9Y6M4 | CSNK1G3 | T399 | ochoa | Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
| Q9Y6R0 | NUMBL | T268 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| V9GYY5 | None | T138 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}. |
| P50914 | RPL14 | T43 | Sugiyama | Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P60174 | TPI1 | T217 | Sugiyama | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}. |
| Q15029 | EFTUD2 | T811 | Sugiyama | 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) | Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:25092792, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:25092792, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000305|PubMed:33509932}. |
| P14618 | PKM | T459 | Sugiyama | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (PubMed:15996096, PubMed:1854723, PubMed:20847263). The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed:15996096, PubMed:1854723, PubMed:20847263). The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263). {ECO:0000269|PubMed:15996096, ECO:0000269|PubMed:1854723, ECO:0000269|PubMed:20847263}.; FUNCTION: [Isoform M2]: Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity (PubMed:18337823, PubMed:20847263). In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase (PubMed:18191611, PubMed:21620138, PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661). Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase (PubMed:22056988, PubMed:22306293, PubMed:22901803, PubMed:24120661, PubMed:26787900). Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription (PubMed:22306293, PubMed:22901803, PubMed:24120661). Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (PubMed:18337823, PubMed:22901803, PubMed:26787900). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages (By similarity). May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (PubMed:17308100). {ECO:0000250|UniProtKB:P52480, ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; FUNCTION: [Isoform M1]: Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823). In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263). {ECO:0000269|PubMed:18337823, ECO:0000269|PubMed:20847263}. |
| O94779 | CNTN5 | T494 | Sugiyama | Contactin-5 (Neural recognition molecule NB-2) (hNB-2) | Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity). {ECO:0000250}. |
| Q8NBJ7 | SUMF2 | T260 | Sugiyama | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}. |
| O95757 | HSPA4L | T35 | Sugiyama | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94) | Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase. {ECO:0000250}. |
| Q8NBJ7 | SUMF2 | T272 | Sugiyama | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. {ECO:0000269|PubMed:12757706, ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}. |
| O75676 | RPS6KA4 | T656 | Sugiyama | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:9792677}. |
| P00558 | PGK1 | T369 | Sugiyama | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| Q6FI81 | CIAPIN1 | T250 | Sugiyama | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}. |
| P02545 | LMNA | T519 | Sugiyama | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
| Q15084 | PDIA6 | T239 | Sugiyama | Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936, ECO:0000269|PubMed:24508390}. |
| Q13283 | G3BP1 | T71 | Sugiyama | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q02790 | FKBP4 | T106 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| P31948 | STIP1 | T64 | Sugiyama | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| O94919 | ENDOD1 | T132 | Sugiyama | Endonuclease domain-containing 1 protein (EC 3.1.30.-) | May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. {ECO:0000269|PubMed:32614325}. |
| O60941 | DTNB | T424 | EPSD|PSP | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| Q8TD08 | MAPK15 | T421 | Sugiyama | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936). {ECO:0000250|UniProtKB:Q80Y86, ECO:0000250|UniProtKB:Q9Z2A6, ECO:0000269|PubMed:11875070, ECO:0000269|PubMed:16484222, ECO:0000269|PubMed:19166846, ECO:0000269|PubMed:20638370, ECO:0000269|PubMed:20733054, ECO:0000269|PubMed:21190936, ECO:0000269|PubMed:21847093, ECO:0000269|PubMed:22948227, ECO:0000269|PubMed:24618899, ECO:0000269|PubMed:26595526, ECO:0000269|PubMed:28842414, ECO:0000269|PubMed:29021280}. |
| Q14195 | DPYSL3 | T508 | EPSD | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}. |
| Q07666 | KHDRBS1 | T72 | SIGNOR | KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68) | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (PubMed:26080397). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). {ECO:0000250|UniProtKB:Q60749, ECO:0000269|PubMed:15021911, ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20186123, ECO:0000269|PubMed:20610388, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:26080397, ECO:0000269|PubMed:26758068}.; FUNCTION: Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. {ECO:0000269|PubMed:9013542}. |
| Q99798 | ACO2 | T646 | Sugiyama | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| P62258 | YWHAE | T161 | Sugiyama | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
| P34932 | HSPA4 | T35 | Sugiyama | Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2) | None |
| Q9UNF1 | MAGED2 | T92 | Sugiyama | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}. |
| P35221 | CTNNA1 | T762 | Sugiyama | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. {ECO:0000250|UniProtKB:P26231, ECO:0000269|PubMed:25653389}. |
| Q9GZT8 | NIF3L1 | T149 | Sugiyama | NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein) | May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9EQ80}. |
| P46777 | RPL5 | T93 | Sugiyama | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| Q02779 | MAP3K10 | T138 | Sugiyama | Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) | Activates the JUN N-terminal pathway. {ECO:0000250}. |
| Q9H4A3 | WNK1 | T2247 | Sugiyama | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) | Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250|UniProtKB:P83741, ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:15883153, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:17190791, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:19739668, ECO:0000269|PubMed:21220314, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22989884, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:25477473, ECO:0000269|PubMed:27911840, ECO:0000269|PubMed:29196535, ECO:0000269|PubMed:31656913, ECO:0000269|PubMed:33964204, ECO:0000269|PubMed:34289367, ECO:0000269|PubMed:36318922, ECO:0000269|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250|UniProtKB:Q9JIH7, ECO:0000269|PubMed:14645531}. |
| P33316 | DUT | T124 | Sugiyama | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) | Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P70583, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:17880943, ECO:0000269|PubMed:8631816, ECO:0000269|PubMed:8805593}. |
| P49792 | RANBP2 | T1756 | Sugiyama | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P08865 | RPSA | T144 | Sugiyama | Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.; FUNCTION: (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; FUNCTION: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.; FUNCTION: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.; FUNCTION: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}. |
| Q9P2R3 | ANKFY1 | T455 | Sugiyama | Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif) | Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721}. |
| Q5S007 | LRRK2 | T1967 | SIGNOR|EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q6XUX3 | DSTYK | T618 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| Q14203 | DCTN1 | T509 | Sugiyama | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q96D15 | RCN3 | T124 | Sugiyama | Reticulocalbin-3 (EF-hand calcium-binding protein RLP49) | Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634). {ECO:0000250|UniProtKB:Q8BH97, ECO:0000269|PubMed:16433634, ECO:0000269|PubMed:28939891}. |
| O43175 | PHGDH | T353 | Sugiyama | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269|PubMed:11751922, ECO:0000269|PubMed:25406093}. |
| P05388 | RPLP0 | T128 | Sugiyama | Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. |
| P30084 | ECHS1 | T169 | Sugiyama | Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH) | Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:26251176). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA) (PubMed:26251176). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (PubMed:26251176). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:25125611, PubMed:26251176). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity). {ECO:0000250|UniProtKB:P14604, ECO:0000269|PubMed:25125611, ECO:0000269|PubMed:26251176}. |
| Q8NHW5 | RPLP0P6 | T128 | Sugiyama | Putative ribosomal protein uL10-like (60S acidic ribosomal protein P0-like) (Large ribosomal subunit protein uL10-like) | Ribosomal protein P0 is the functional equivalent of E.coli protein L10. {ECO:0000250}. |
| Q99798 | ACO2 | T415 | Sugiyama | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}. |
| P06733 | ENO1 | T229 | Sugiyama | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P12109 | COL6A1 | T205 | Sugiyama | Collagen alpha-1(VI) chain | Collagen VI acts as a cell-binding protein. |
| P49327 | FASN | T1150 | Sugiyama | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q9Y490 | TLN1 | T2204 | Sugiyama | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4G6 | TLN2 | T2205 | Sugiyama | Talin-2 | As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity). {ECO:0000250}. |
| P07339 | CTSD | T35 | Sugiyama | Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}. |
| Q9NWZ3 | IRAK4 | T119 | Sugiyama | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q99575 | POP1 | T106 | Sugiyama | Ribonucleases P/MRP protein subunit POP1 (hPOP1) | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648, ECO:0000269|PubMed:8918471}. |
| Q9Y6I9 | TEX264 | T257 | Sugiyama | Testis-expressed protein 264 (Putative secreted protein Zsig11) | Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538, ECO:0000269|PubMed:32152270}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-75153 | Apoptotic execution phase | 7.364128e-08 | 7.133 |
| R-HSA-422475 | Axon guidance | 1.467802e-05 | 4.833 |
| R-HSA-9675108 | Nervous system development | 1.562918e-05 | 4.806 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 7.083704e-06 | 5.150 |
| R-HSA-2262752 | Cellular responses to stress | 1.187058e-05 | 4.926 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.409892e-05 | 4.851 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.101003e-05 | 4.958 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.849659e-05 | 4.733 |
| R-HSA-3371556 | Cellular response to heat stress | 4.159637e-05 | 4.381 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 1.468918e-04 | 3.833 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.434284e-04 | 3.614 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 2.782587e-04 | 3.556 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 3.621851e-04 | 3.441 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 4.389823e-04 | 3.358 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.001357e-04 | 3.398 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 4.389823e-04 | 3.358 |
| R-HSA-109581 | Apoptosis | 4.873710e-04 | 3.312 |
| R-HSA-354192 | Integrin signaling | 7.654679e-04 | 3.116 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.096833e-03 | 2.960 |
| R-HSA-1500931 | Cell-Cell communication | 1.283082e-03 | 2.892 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 1.393934e-03 | 2.856 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 1.405329e-03 | 2.852 |
| R-HSA-9762292 | Regulation of CDH11 function | 1.763361e-03 | 2.754 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 1.763361e-03 | 2.754 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 1.824345e-03 | 2.739 |
| R-HSA-909733 | Interferon alpha/beta signaling | 2.563457e-03 | 2.591 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.707250e-03 | 2.567 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.899108e-03 | 2.538 |
| R-HSA-5357801 | Programmed Cell Death | 2.817915e-03 | 2.550 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 3.160329e-03 | 2.500 |
| R-HSA-9842663 | Signaling by LTK | 3.160329e-03 | 2.500 |
| R-HSA-446728 | Cell junction organization | 3.216303e-03 | 2.493 |
| R-HSA-9796292 | Formation of axial mesoderm | 3.741247e-03 | 2.427 |
| R-HSA-9634597 | GPER1 signaling | 3.656786e-03 | 2.437 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.889261e-03 | 2.410 |
| R-HSA-70171 | Glycolysis | 4.277217e-03 | 2.369 |
| R-HSA-3371571 | HSF1-dependent transactivation | 4.546942e-03 | 2.342 |
| R-HSA-191650 | Regulation of gap junction activity | 5.381735e-03 | 2.269 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.672575e-03 | 2.246 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 7.239429e-03 | 2.140 |
| R-HSA-8849468 | PTK6 Regulates Proteins Involved in RNA Processing | 7.239429e-03 | 2.140 |
| R-HSA-8853659 | RET signaling | 7.932009e-03 | 2.101 |
| R-HSA-2028269 | Signaling by Hippo | 7.594535e-03 | 2.119 |
| R-HSA-8941326 | RUNX2 regulates bone development | 7.932009e-03 | 2.101 |
| R-HSA-3928664 | Ephrin signaling | 8.565346e-03 | 2.067 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 8.576826e-03 | 2.067 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.868069e-03 | 2.052 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 9.345106e-03 | 2.029 |
| R-HSA-373755 | Semaphorin interactions | 9.665268e-03 | 2.015 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.079332e-02 | 1.967 |
| R-HSA-3371568 | Attenuation phase | 1.071396e-02 | 1.970 |
| R-HSA-9823730 | Formation of definitive endoderm | 1.071652e-02 | 1.970 |
| R-HSA-421270 | Cell-cell junction organization | 1.071057e-02 | 1.970 |
| R-HSA-70326 | Glucose metabolism | 1.012769e-02 | 1.994 |
| R-HSA-166520 | Signaling by NTRKs | 1.102767e-02 | 1.958 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 1.149597e-02 | 1.939 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.231376e-02 | 1.910 |
| R-HSA-5674135 | MAP2K and MAPK activation | 1.231376e-02 | 1.910 |
| R-HSA-9837999 | Mitochondrial protein degradation | 1.191796e-02 | 1.924 |
| R-HSA-418990 | Adherens junctions interactions | 1.174370e-02 | 1.930 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.297735e-02 | 1.887 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.315280e-02 | 1.881 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 1.426327e-02 | 1.846 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 1.426327e-02 | 1.846 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.426327e-02 | 1.846 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.529096e-02 | 1.816 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 1.695782e-02 | 1.771 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 1.695782e-02 | 1.771 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 1.695782e-02 | 1.771 |
| R-HSA-6802949 | Signaling by RAS mutants | 1.695782e-02 | 1.771 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.673534e-02 | 1.776 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.620179e-02 | 1.790 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 1.705781e-02 | 1.768 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.800095e-02 | 1.745 |
| R-HSA-8939211 | ESR-mediated signaling | 1.894216e-02 | 1.723 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.842554e-02 | 1.735 |
| R-HSA-70263 | Gluconeogenesis | 1.908316e-02 | 1.719 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.008757e-02 | 1.697 |
| R-HSA-9766229 | Degradation of CDH1 | 2.020484e-02 | 1.695 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 2.151023e-02 | 1.667 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 2.229266e-02 | 1.652 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 2.229266e-02 | 1.652 |
| R-HSA-525793 | Myogenesis | 2.052122e-02 | 1.688 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.206619e-02 | 1.656 |
| R-HSA-74749 | Signal attenuation | 2.327475e-02 | 1.633 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 2.327475e-02 | 1.633 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.393322e-02 | 1.621 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.393322e-02 | 1.621 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 2.398602e-02 | 1.620 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.401368e-02 | 1.620 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.668064e-02 | 1.574 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 2.668064e-02 | 1.574 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 2.668064e-02 | 1.574 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.727868e-02 | 1.564 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 3.027417e-02 | 1.519 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 2.774717e-02 | 1.557 |
| R-HSA-9764561 | Regulation of CDH1 Function | 3.063491e-02 | 1.514 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.020856e-02 | 1.520 |
| R-HSA-193648 | NRAGE signals death through JNK | 2.918723e-02 | 1.535 |
| R-HSA-2559583 | Cellular Senescence | 2.871555e-02 | 1.542 |
| R-HSA-177929 | Signaling by EGFR | 2.918723e-02 | 1.535 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 3.118812e-02 | 1.506 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 3.118812e-02 | 1.506 |
| R-HSA-373760 | L1CAM interactions | 3.118812e-02 | 1.506 |
| R-HSA-9699150 | Defective DNA double strand break response due to BARD1 loss of function | 3.525954e-02 | 1.453 |
| R-HSA-9663199 | Defective DNA double strand break response due to BRCA1 loss of function | 3.525954e-02 | 1.453 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.394145e-02 | 1.469 |
| R-HSA-156902 | Peptide chain elongation | 3.182684e-02 | 1.497 |
| R-HSA-199991 | Membrane Trafficking | 3.438241e-02 | 1.464 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.494611e-02 | 1.457 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.505476e-02 | 1.455 |
| R-HSA-1227986 | Signaling by ERBB2 | 3.522851e-02 | 1.453 |
| R-HSA-913531 | Interferon Signaling | 3.234406e-02 | 1.490 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 3.553154e-02 | 1.449 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 3.682311e-02 | 1.434 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 3.814323e-02 | 1.419 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.615231e-02 | 1.442 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 4.079053e-02 | 1.389 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.862687e-02 | 1.413 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 3.799353e-02 | 1.420 |
| R-HSA-1266738 | Developmental Biology | 3.734190e-02 | 1.428 |
| R-HSA-72312 | rRNA processing | 4.002785e-02 | 1.398 |
| R-HSA-8848021 | Signaling by PTK6 | 4.019992e-02 | 1.396 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.019992e-02 | 1.396 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 4.019992e-02 | 1.396 |
| R-HSA-73887 | Death Receptor Signaling | 3.722441e-02 | 1.429 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.194123e-02 | 1.377 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 4.210459e-02 | 1.376 |
| R-HSA-194138 | Signaling by VEGF | 4.213274e-02 | 1.375 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.227582e-02 | 1.374 |
| R-HSA-3371511 | HSF1 activation | 4.321683e-02 | 1.364 |
| R-HSA-9027284 | Erythropoietin activates RAS | 4.637374e-02 | 1.334 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 4.637374e-02 | 1.334 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 5.079408e-02 | 1.294 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 4.932711e-02 | 1.307 |
| R-HSA-418885 | DCC mediated attractive signaling | 4.637374e-02 | 1.334 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 5.079408e-02 | 1.294 |
| R-HSA-72764 | Eukaryotic Translation Termination | 4.371105e-02 | 1.359 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.372465e-02 | 1.359 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.555013e-02 | 1.342 |
| R-HSA-3214847 | HATs acetylate histones | 4.974215e-02 | 1.303 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.840874e-02 | 1.315 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.577794e-02 | 1.339 |
| R-HSA-9706369 | Negative regulation of FLT3 | 5.079408e-02 | 1.294 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.372465e-02 | 1.359 |
| R-HSA-201556 | Signaling by ALK | 5.091697e-02 | 1.293 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 5.127846e-02 | 1.290 |
| R-HSA-9916720 | Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 | 5.242190e-02 | 1.280 |
| R-HSA-352238 | Breakdown of the nuclear lamina | 5.242190e-02 | 1.280 |
| R-HSA-2408557 | Selenocysteine synthesis | 5.293238e-02 | 1.276 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.293238e-02 | 1.276 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.327156e-02 | 1.274 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 6.006180e-02 | 1.221 |
| R-HSA-192823 | Viral mRNA Translation | 5.623924e-02 | 1.250 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 6.489636e-02 | 1.188 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 6.165887e-02 | 1.210 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 6.489636e-02 | 1.188 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 5.639429e-02 | 1.249 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.793640e-02 | 1.237 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.793640e-02 | 1.237 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 6.501604e-02 | 1.187 |
| R-HSA-9700206 | Signaling by ALK in cancer | 6.501604e-02 | 1.187 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.511003e-02 | 1.186 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 6.320256e-02 | 1.199 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 6.511003e-02 | 1.186 |
| R-HSA-180292 | GAB1 signalosome | 6.489636e-02 | 1.188 |
| R-HSA-9020591 | Interleukin-12 signaling | 6.609901e-02 | 1.180 |
| R-HSA-5619104 | Defective SLC12A1 causes Bartter syndrome 1 (BS1) | 6.927999e-02 | 1.159 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 8.583918e-02 | 1.066 |
| R-HSA-74713 | IRS activation | 1.180819e-01 | 0.928 |
| R-HSA-5603029 | IkBA variant leads to EDA-ID | 1.337757e-01 | 0.874 |
| R-HSA-9027283 | Erythropoietin activates STAT5 | 1.491912e-01 | 0.826 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 1.643333e-01 | 0.784 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 1.643333e-01 | 0.784 |
| R-HSA-112412 | SOS-mediated signalling | 1.643333e-01 | 0.784 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.792068e-01 | 0.747 |
| R-HSA-9613354 | Lipophagy | 1.938165e-01 | 0.713 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 8.012973e-02 | 1.096 |
| R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 2.081670e-01 | 0.682 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 8.543145e-02 | 1.068 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 1.019319e-01 | 0.992 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 1.019319e-01 | 0.992 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 2.361088e-01 | 0.627 |
| R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 2.497091e-01 | 0.603 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.497091e-01 | 0.603 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.497091e-01 | 0.603 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.497091e-01 | 0.603 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.497091e-01 | 0.603 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.497091e-01 | 0.603 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.192188e-01 | 0.924 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.192188e-01 | 0.924 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.192188e-01 | 0.924 |
| R-HSA-171306 | Packaging Of Telomere Ends | 1.192188e-01 | 0.924 |
| R-HSA-170660 | Adenylate cyclase activating pathway | 2.630679e-01 | 0.580 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.311170e-01 | 0.882 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.311170e-01 | 0.882 |
| R-HSA-1663150 | The activation of arylsulfatases | 2.761898e-01 | 0.559 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 8.090811e-02 | 1.092 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 1.494377e-01 | 0.826 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 2.890788e-01 | 0.539 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.890788e-01 | 0.539 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.890788e-01 | 0.539 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 3.017391e-01 | 0.520 |
| R-HSA-176412 | Phosphorylation of the APC/C | 3.017391e-01 | 0.520 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.017391e-01 | 0.520 |
| R-HSA-72649 | Translation initiation complex formation | 1.018081e-01 | 0.992 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 3.141746e-01 | 0.503 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.092078e-01 | 0.962 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 1.168089e-01 | 0.933 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 3.263895e-01 | 0.486 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.366308e-01 | 0.864 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.366308e-01 | 0.864 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.490385e-01 | 0.827 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.792836e-01 | 0.746 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.528694e-01 | 0.597 |
| R-HSA-380287 | Centrosome maturation | 1.882156e-01 | 0.725 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.533894e-01 | 0.596 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.866376e-01 | 0.729 |
| R-HSA-72172 | mRNA Splicing | 2.169378e-01 | 0.664 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 9.068654e-02 | 1.042 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.206820e-01 | 0.918 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.629762e-01 | 0.580 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 7.451652e-02 | 1.128 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 2.921431e-01 | 0.534 |
| R-HSA-157579 | Telomere Maintenance | 3.065638e-01 | 0.513 |
| R-HSA-180786 | Extension of Telomeres | 3.384091e-01 | 0.471 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.643333e-01 | 0.784 |
| R-HSA-198203 | PI3K/AKT activation | 2.081670e-01 | 0.682 |
| R-HSA-171319 | Telomere Extension By Telomerase | 1.251335e-01 | 0.903 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 7.451652e-02 | 1.128 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.485841e-01 | 0.828 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.682300e-01 | 0.774 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 1.682300e-01 | 0.774 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.497091e-01 | 0.603 |
| R-HSA-418457 | cGMP effects | 2.761898e-01 | 0.559 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 2.890788e-01 | 0.539 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 3.141746e-01 | 0.503 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 2.068416e-01 | 0.684 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.532531e-01 | 0.815 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 6.985649e-02 | 1.156 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.211804e-01 | 0.493 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 2.156494e-01 | 0.666 |
| R-HSA-167044 | Signalling to RAS | 8.012973e-02 | 1.096 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 2.968336e-01 | 0.527 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 8.993824e-02 | 1.046 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 1.180819e-01 | 0.928 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 1.180819e-01 | 0.928 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.491912e-01 | 0.826 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.792068e-01 | 0.747 |
| R-HSA-1221632 | Meiotic synapsis | 9.818664e-02 | 1.008 |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | 3.263895e-01 | 0.486 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 3.383875e-01 | 0.471 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.570027e-01 | 0.804 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.764418e-01 | 0.558 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 9.183239e-02 | 1.037 |
| R-HSA-2424491 | DAP12 signaling | 1.371650e-01 | 0.863 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.922507e-01 | 0.716 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.141746e-01 | 0.503 |
| R-HSA-9865881 | Complex III assembly | 1.019319e-01 | 0.992 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 3.141746e-01 | 0.503 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.105615e-01 | 0.677 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 1.364258e-01 | 0.865 |
| R-HSA-5673000 | RAF activation | 1.682300e-01 | 0.774 |
| R-HSA-5693538 | Homology Directed Repair | 9.119556e-02 | 1.040 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 3.016967e-01 | 0.520 |
| R-HSA-74752 | Signaling by Insulin receptor | 2.774379e-01 | 0.557 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 1.938165e-01 | 0.713 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 2.761898e-01 | 0.559 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.278936e-01 | 0.484 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.330693e-01 | 0.633 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 1.021047e-01 | 0.991 |
| R-HSA-9032759 | NTRK2 activates RAC1 | 1.180819e-01 | 0.928 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.019319e-01 | 0.992 |
| R-HSA-209560 | NF-kB is activated and signals survival | 2.361088e-01 | 0.627 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.497091e-01 | 0.603 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.890788e-01 | 0.539 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 2.890788e-01 | 0.539 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 1.682300e-01 | 0.774 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 3.141746e-01 | 0.503 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.809709e-01 | 0.742 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 3.383875e-01 | 0.471 |
| R-HSA-164378 | PKA activation in glucagon signalling | 3.383875e-01 | 0.471 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.190064e-01 | 0.924 |
| R-HSA-1500620 | Meiosis | 2.343818e-01 | 0.630 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.016967e-01 | 0.520 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.541748e-01 | 0.812 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.541748e-01 | 0.812 |
| R-HSA-9664407 | Parasite infection | 1.541748e-01 | 0.812 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3.383875e-01 | 0.471 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.203030e-01 | 0.657 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 3.017391e-01 | 0.520 |
| R-HSA-9664420 | Killing mechanisms | 3.017391e-01 | 0.520 |
| R-HSA-8851805 | MET activates RAS signaling | 2.497091e-01 | 0.603 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.890788e-01 | 0.539 |
| R-HSA-171007 | p38MAPK events | 2.890788e-01 | 0.539 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 1.938499e-01 | 0.713 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 8.543145e-02 | 1.068 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 1.129838e-01 | 0.947 |
| R-HSA-68875 | Mitotic Prophase | 2.217777e-01 | 0.654 |
| R-HSA-1433559 | Regulation of KIT signaling | 2.761898e-01 | 0.559 |
| R-HSA-8983432 | Interleukin-15 signaling | 2.497091e-01 | 0.603 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.430822e-01 | 0.844 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 1.325775e-01 | 0.878 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.919753e-01 | 0.535 |
| R-HSA-205025 | NADE modulates death signalling | 1.021047e-01 | 0.991 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 1.491912e-01 | 0.826 |
| R-HSA-426048 | Arachidonate production from DAG | 2.081670e-01 | 0.682 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 2.222630e-01 | 0.653 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 2.630679e-01 | 0.580 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 7.440392e-02 | 1.128 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.682300e-01 | 0.774 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 3.141746e-01 | 0.503 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.141746e-01 | 0.503 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.168089e-01 | 0.933 |
| R-HSA-8875878 | MET promotes cell motility | 1.938499e-01 | 0.713 |
| R-HSA-2172127 | DAP12 interactions | 2.396612e-01 | 0.620 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 2.296703e-01 | 0.639 |
| R-HSA-68886 | M Phase | 3.003818e-01 | 0.522 |
| R-HSA-68877 | Mitotic Prometaphase | 3.328257e-01 | 0.478 |
| R-HSA-445355 | Smooth Muscle Contraction | 2.991190e-01 | 0.524 |
| R-HSA-69481 | G2/M Checkpoints | 2.523993e-01 | 0.598 |
| R-HSA-9818749 | Regulation of NFE2L2 gene expression | 1.491912e-01 | 0.826 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.938165e-01 | 0.713 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 1.745815e-01 | 0.758 |
| R-HSA-5260271 | Diseases of Immune System | 2.068416e-01 | 0.684 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.068416e-01 | 0.684 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 9.374807e-02 | 1.028 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.991190e-01 | 0.524 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.748626e-01 | 0.757 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 2.361088e-01 | 0.627 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.141746e-01 | 0.503 |
| R-HSA-416482 | G alpha (12/13) signalling events | 7.070121e-02 | 1.151 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.383875e-01 | 0.471 |
| R-HSA-373752 | Netrin-1 signaling | 2.396612e-01 | 0.620 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 6.985649e-02 | 1.156 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.662902e-01 | 0.779 |
| R-HSA-1640170 | Cell Cycle | 3.311777e-01 | 0.480 |
| R-HSA-9658195 | Leishmania infection | 1.767658e-01 | 0.753 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.767658e-01 | 0.753 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 1.180819e-01 | 0.928 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 1.337757e-01 | 0.874 |
| R-HSA-418886 | Netrin mediated repulsion signals | 1.643333e-01 | 0.784 |
| R-HSA-390696 | Adrenoceptors | 1.792068e-01 | 0.747 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.938165e-01 | 0.713 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 1.938165e-01 | 0.713 |
| R-HSA-6807047 | Cholesterol biosynthesis via desmosterol | 2.222630e-01 | 0.653 |
| R-HSA-428540 | Activation of RAC1 | 2.361088e-01 | 0.627 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 2.497091e-01 | 0.603 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.630679e-01 | 0.580 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 2.761898e-01 | 0.559 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 2.761898e-01 | 0.559 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 2.761898e-01 | 0.559 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 2.890788e-01 | 0.539 |
| R-HSA-163615 | PKA activation | 3.383875e-01 | 0.471 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 1.882156e-01 | 0.725 |
| R-HSA-9711097 | Cellular response to starvation | 9.962349e-02 | 1.002 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 2.925264e-01 | 0.534 |
| R-HSA-418555 | G alpha (s) signalling events | 2.570077e-01 | 0.590 |
| R-HSA-8953854 | Metabolism of RNA | 9.312397e-02 | 1.031 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.312876e-01 | 0.882 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 1.566858e-01 | 0.805 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.074904e-01 | 0.969 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 2.110172e-01 | 0.676 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.938165e-01 | 0.713 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 3.141746e-01 | 0.503 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 3.141746e-01 | 0.503 |
| R-HSA-110331 | Cleavage of the damaged purine | 1.873947e-01 | 0.727 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.263895e-01 | 0.486 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.263895e-01 | 0.486 |
| R-HSA-187687 | Signalling to ERKs | 1.745815e-01 | 0.758 |
| R-HSA-1632852 | Macroautophagy | 3.158140e-01 | 0.501 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.097585e-01 | 0.960 |
| R-HSA-73927 | Depurination | 1.938499e-01 | 0.713 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 2.110172e-01 | 0.676 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.186227e-01 | 0.926 |
| R-HSA-9675135 | Diseases of DNA repair | 2.528694e-01 | 0.597 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.773773e-01 | 0.751 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 1.180819e-01 | 0.928 |
| R-HSA-164944 | Nef and signal transduction | 1.491912e-01 | 0.826 |
| R-HSA-447041 | CHL1 interactions | 1.643333e-01 | 0.784 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.792068e-01 | 0.747 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 1.938165e-01 | 0.713 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.938165e-01 | 0.713 |
| R-HSA-448706 | Interleukin-1 processing | 1.938165e-01 | 0.713 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 2.081670e-01 | 0.682 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.630679e-01 | 0.580 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 2.761898e-01 | 0.559 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.494377e-01 | 0.826 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.890788e-01 | 0.539 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 3.141746e-01 | 0.503 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.792836e-01 | 0.746 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.983313e-02 | 1.047 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.384091e-01 | 0.471 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 2.297099e-01 | 0.639 |
| R-HSA-162582 | Signal Transduction | 1.223794e-01 | 0.912 |
| R-HSA-69620 | Cell Cycle Checkpoints | 2.349539e-01 | 0.629 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 3.114340e-01 | 0.507 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 3.114340e-01 | 0.507 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 3.114340e-01 | 0.507 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 2.133722e-01 | 0.671 |
| R-HSA-114608 | Platelet degranulation | 2.523993e-01 | 0.598 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 1.311170e-01 | 0.882 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 1.371650e-01 | 0.863 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 1.745815e-01 | 0.758 |
| R-HSA-4839726 | Chromatin organization | 1.142285e-01 | 0.942 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 3.232785e-01 | 0.490 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 1.938165e-01 | 0.713 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 2.361088e-01 | 0.627 |
| R-HSA-5578768 | Physiological factors | 2.761898e-01 | 0.559 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.761898e-01 | 0.559 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 1.745815e-01 | 0.758 |
| R-HSA-157858 | Gap junction trafficking and regulation | 2.727078e-01 | 0.564 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.057017e-01 | 0.515 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 7.851727e-02 | 1.105 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.660944e-01 | 0.575 |
| R-HSA-6806834 | Signaling by MET | 2.110172e-01 | 0.676 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.188307e-01 | 0.496 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.076133e-01 | 0.968 |
| R-HSA-193639 | p75NTR signals via NF-kB | 2.890788e-01 | 0.539 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.343818e-01 | 0.630 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.611826e-01 | 0.793 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.494377e-01 | 0.826 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.081670e-01 | 0.682 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 8.543145e-02 | 1.068 |
| R-HSA-210990 | PECAM1 interactions | 2.222630e-01 | 0.653 |
| R-HSA-9635465 | Suppression of apoptosis | 2.222630e-01 | 0.653 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 2.761898e-01 | 0.559 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.761898e-01 | 0.559 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.890788e-01 | 0.539 |
| R-HSA-437239 | Recycling pathway of L1 | 2.594809e-01 | 0.586 |
| R-HSA-9663891 | Selective autophagy | 2.533894e-01 | 0.596 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.798702e-01 | 0.553 |
| R-HSA-168256 | Immune System | 2.958586e-01 | 0.529 |
| R-HSA-73884 | Base Excision Repair | 2.629762e-01 | 0.580 |
| R-HSA-5205647 | Mitophagy | 1.682300e-01 | 0.774 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 1.745815e-01 | 0.758 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.183239e-02 | 1.037 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 1.180819e-01 | 0.928 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 1.661161e-01 | 0.780 |
| R-HSA-9833482 | PKR-mediated signaling | 2.110172e-01 | 0.676 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 3.188307e-01 | 0.496 |
| R-HSA-114604 | GPVI-mediated activation cascade | 1.809709e-01 | 0.742 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 2.859257e-01 | 0.544 |
| R-HSA-190236 | Signaling by FGFR | 3.114340e-01 | 0.507 |
| R-HSA-168255 | Influenza Infection | 1.483238e-01 | 0.829 |
| R-HSA-5654741 | Signaling by FGFR3 | 7.124330e-02 | 1.147 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.222630e-01 | 0.653 |
| R-HSA-8876725 | Protein methylation | 2.890788e-01 | 0.539 |
| R-HSA-5654738 | Signaling by FGFR2 | 2.110172e-01 | 0.676 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 1.704730e-01 | 0.768 |
| R-HSA-2586552 | Signaling by Leptin | 2.081670e-01 | 0.682 |
| R-HSA-9020558 | Interleukin-2 signaling | 2.222630e-01 | 0.653 |
| R-HSA-5654736 | Signaling by FGFR1 | 1.092078e-01 | 0.962 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.486153e-01 | 0.604 |
| R-HSA-391160 | Signal regulatory protein family interactions | 2.761898e-01 | 0.559 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.890788e-01 | 0.539 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.925264e-01 | 0.534 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.925111e-01 | 0.716 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.430822e-01 | 0.844 |
| R-HSA-70268 | Pyruvate metabolism | 2.486153e-01 | 0.604 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.192188e-01 | 0.924 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.938499e-01 | 0.713 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 9.119556e-02 | 1.040 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 3.057017e-01 | 0.515 |
| R-HSA-8863678 | Neurodegenerative Diseases | 1.019319e-01 | 0.992 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 1.019319e-01 | 0.992 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.890788e-01 | 0.539 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 1.192188e-01 | 0.924 |
| R-HSA-449147 | Signaling by Interleukins | 2.734410e-01 | 0.563 |
| R-HSA-9645723 | Diseases of programmed cell death | 2.533894e-01 | 0.596 |
| R-HSA-73943 | Reversal of alkylation damage by DNA dioxygenases | 2.497091e-01 | 0.603 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 7.306245e-02 | 1.136 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 3.384091e-01 | 0.471 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.180211e-01 | 0.662 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.371650e-01 | 0.863 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.619198e-01 | 0.791 |
| R-HSA-210993 | Tie2 Signaling | 3.383875e-01 | 0.471 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.081032e-01 | 0.682 |
| R-HSA-73942 | DNA Damage Reversal | 2.890788e-01 | 0.539 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.305400e-01 | 0.637 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.060035e-01 | 0.686 |
| R-HSA-69236 | G1 Phase | 2.396612e-01 | 0.620 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.396612e-01 | 0.620 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.309294e-01 | 0.480 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 2.264887e-01 | 0.645 |
| R-HSA-73928 | Depyrimidination | 2.264887e-01 | 0.645 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 1.682300e-01 | 0.774 |
| R-HSA-9607240 | FLT3 Signaling | 2.133722e-01 | 0.671 |
| R-HSA-4086400 | PCP/CE pathway | 2.018213e-01 | 0.695 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 2.705106e-01 | 0.568 |
| R-HSA-447115 | Interleukin-12 family signaling | 9.606404e-02 | 1.017 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 3.448985e-01 | 0.462 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 3.455443e-01 | 0.461 |
| R-HSA-195721 | Signaling by WNT | 3.462974e-01 | 0.461 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.480811e-01 | 0.458 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 3.501726e-01 | 0.456 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 3.501726e-01 | 0.456 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 3.501726e-01 | 0.456 |
| R-HSA-9834899 | Specification of the neural plate border | 3.501726e-01 | 0.456 |
| R-HSA-392517 | Rap1 signalling | 3.501726e-01 | 0.456 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 3.501726e-01 | 0.456 |
| R-HSA-844456 | The NLRP3 inflammasome | 3.501726e-01 | 0.456 |
| R-HSA-1442490 | Collagen degradation | 3.513672e-01 | 0.454 |
| R-HSA-9758941 | Gastrulation | 3.521227e-01 | 0.453 |
| R-HSA-6798695 | Neutrophil degranulation | 3.564183e-01 | 0.448 |
| R-HSA-389948 | Co-inhibition by PD-1 | 3.574690e-01 | 0.447 |
| R-HSA-1268020 | Mitochondrial protein import | 3.578140e-01 | 0.446 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.578140e-01 | 0.446 |
| R-HSA-186797 | Signaling by PDGF | 3.578140e-01 | 0.446 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 3.617485e-01 | 0.442 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.617485e-01 | 0.442 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 3.617485e-01 | 0.442 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 3.617485e-01 | 0.442 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.617485e-01 | 0.442 |
| R-HSA-445144 | Signal transduction by L1 | 3.617485e-01 | 0.442 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 3.617485e-01 | 0.442 |
| R-HSA-373753 | Nephrin family interactions | 3.617485e-01 | 0.442 |
| R-HSA-6799198 | Complex I biogenesis | 3.642375e-01 | 0.439 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 3.642478e-01 | 0.439 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.642478e-01 | 0.439 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.645267e-01 | 0.438 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.649834e-01 | 0.438 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.698300e-01 | 0.432 |
| R-HSA-74751 | Insulin receptor signalling cascade | 3.706365e-01 | 0.431 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 3.731188e-01 | 0.428 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.731188e-01 | 0.428 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.731188e-01 | 0.428 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 3.731188e-01 | 0.428 |
| R-HSA-210991 | Basigin interactions | 3.731188e-01 | 0.428 |
| R-HSA-73894 | DNA Repair | 3.741350e-01 | 0.427 |
| R-HSA-9612973 | Autophagy | 3.803990e-01 | 0.420 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 3.842873e-01 | 0.415 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 3.842873e-01 | 0.415 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 3.842873e-01 | 0.415 |
| R-HSA-977347 | Serine metabolism | 3.842873e-01 | 0.415 |
| R-HSA-2022377 | Metabolism of Angiotensinogen to Angiotensins | 3.842873e-01 | 0.415 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 3.843276e-01 | 0.415 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.891439e-01 | 0.410 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 3.896754e-01 | 0.409 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 3.952575e-01 | 0.403 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.952575e-01 | 0.403 |
| R-HSA-9669938 | Signaling by KIT in disease | 3.952575e-01 | 0.403 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.952575e-01 | 0.403 |
| R-HSA-6807062 | Cholesterol biosynthesis via lathosterol | 3.952575e-01 | 0.403 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.952575e-01 | 0.403 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 3.959654e-01 | 0.402 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 3.959654e-01 | 0.402 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.035356e-01 | 0.394 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 4.060328e-01 | 0.391 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 4.060328e-01 | 0.391 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 4.060328e-01 | 0.391 |
| R-HSA-982772 | Growth hormone receptor signaling | 4.060328e-01 | 0.391 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 4.084551e-01 | 0.389 |
| R-HSA-204005 | COPII-mediated vesicle transport | 4.084551e-01 | 0.389 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.146530e-01 | 0.382 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 4.166169e-01 | 0.380 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 4.166169e-01 | 0.380 |
| R-HSA-429947 | Deadenylation of mRNA | 4.166169e-01 | 0.380 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 4.166169e-01 | 0.380 |
| R-HSA-68882 | Mitotic Anaphase | 4.174010e-01 | 0.379 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.208184e-01 | 0.376 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.208184e-01 | 0.376 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.209091e-01 | 0.376 |
| R-HSA-4086398 | Ca2+ pathway | 4.269505e-01 | 0.370 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 4.270130e-01 | 0.370 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.270130e-01 | 0.370 |
| R-HSA-420029 | Tight junction interactions | 4.270130e-01 | 0.370 |
| R-HSA-9620244 | Long-term potentiation | 4.270130e-01 | 0.370 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.270130e-01 | 0.370 |
| R-HSA-9830364 | Formation of the nephric duct | 4.270130e-01 | 0.370 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.270130e-01 | 0.370 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.270130e-01 | 0.370 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 4.270130e-01 | 0.370 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 4.270130e-01 | 0.370 |
| R-HSA-1266695 | Interleukin-7 signaling | 4.270130e-01 | 0.370 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.272968e-01 | 0.369 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.272968e-01 | 0.369 |
| R-HSA-1236394 | Signaling by ERBB4 | 4.330486e-01 | 0.363 |
| R-HSA-73886 | Chromosome Maintenance | 4.367100e-01 | 0.360 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.367100e-01 | 0.360 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.367100e-01 | 0.360 |
| R-HSA-8874081 | MET activates PTK2 signaling | 4.372244e-01 | 0.359 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.372244e-01 | 0.359 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 4.372244e-01 | 0.359 |
| R-HSA-5689901 | Metalloprotease DUBs | 4.372244e-01 | 0.359 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.372244e-01 | 0.359 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 4.372244e-01 | 0.359 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 4.391119e-01 | 0.357 |
| R-HSA-8852135 | Protein ubiquitination | 4.391119e-01 | 0.357 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 4.413951e-01 | 0.355 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 4.413951e-01 | 0.355 |
| R-HSA-5689603 | UCH proteinases | 4.451398e-01 | 0.352 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 4.460652e-01 | 0.351 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 4.472545e-01 | 0.349 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 4.472545e-01 | 0.349 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 4.472545e-01 | 0.349 |
| R-HSA-8949613 | Cristae formation | 4.472545e-01 | 0.349 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 4.472545e-01 | 0.349 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 4.472545e-01 | 0.349 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 4.472545e-01 | 0.349 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.482812e-01 | 0.348 |
| R-HSA-6809371 | Formation of the cornified envelope | 4.507198e-01 | 0.346 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 4.511315e-01 | 0.346 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 4.522121e-01 | 0.345 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 4.522121e-01 | 0.345 |
| R-HSA-167287 | HIV elongation arrest and recovery | 4.571064e-01 | 0.340 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 4.571064e-01 | 0.340 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 4.571064e-01 | 0.340 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 4.571064e-01 | 0.340 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 4.571064e-01 | 0.340 |
| R-HSA-77387 | Insulin receptor recycling | 4.571064e-01 | 0.340 |
| R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 4.571064e-01 | 0.340 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 4.571064e-01 | 0.340 |
| R-HSA-622312 | Inflammasomes | 4.571064e-01 | 0.340 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 4.599809e-01 | 0.337 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 4.599809e-01 | 0.337 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 4.599809e-01 | 0.337 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 4.630041e-01 | 0.334 |
| R-HSA-9659379 | Sensory processing of sound | 4.630041e-01 | 0.334 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 4.645866e-01 | 0.333 |
| R-HSA-5334118 | DNA methylation | 4.667833e-01 | 0.331 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.667833e-01 | 0.331 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 4.667833e-01 | 0.331 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.667833e-01 | 0.331 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.667833e-01 | 0.331 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 4.667833e-01 | 0.331 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.667833e-01 | 0.331 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.688838e-01 | 0.329 |
| R-HSA-611105 | Respiratory electron transport | 4.717263e-01 | 0.326 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 4.737460e-01 | 0.324 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.762884e-01 | 0.322 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.762884e-01 | 0.322 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 4.762884e-01 | 0.322 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 4.762884e-01 | 0.322 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.762884e-01 | 0.322 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 4.762884e-01 | 0.322 |
| R-HSA-114452 | Activation of BH3-only proteins | 4.762884e-01 | 0.322 |
| R-HSA-109582 | Hemostasis | 4.780622e-01 | 0.321 |
| R-HSA-69278 | Cell Cycle, Mitotic | 4.847911e-01 | 0.314 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.856245e-01 | 0.314 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.856245e-01 | 0.314 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 4.856245e-01 | 0.314 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.856245e-01 | 0.314 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.856245e-01 | 0.314 |
| R-HSA-186763 | Downstream signal transduction | 4.856245e-01 | 0.314 |
| R-HSA-1474165 | Reproduction | 4.873496e-01 | 0.312 |
| R-HSA-9843745 | Adipogenesis | 4.918465e-01 | 0.308 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 4.920137e-01 | 0.308 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.937838e-01 | 0.306 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.947948e-01 | 0.306 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.947948e-01 | 0.306 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 4.947948e-01 | 0.306 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 5.033389e-01 | 0.298 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 5.033389e-01 | 0.298 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 5.038022e-01 | 0.298 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 5.038022e-01 | 0.298 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 5.038022e-01 | 0.298 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 5.038022e-01 | 0.298 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 5.038022e-01 | 0.298 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 5.038022e-01 | 0.298 |
| R-HSA-9733709 | Cardiogenesis | 5.038022e-01 | 0.298 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 5.038022e-01 | 0.298 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 5.089403e-01 | 0.293 |
| R-HSA-390522 | Striated Muscle Contraction | 5.126495e-01 | 0.290 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 5.126495e-01 | 0.290 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 5.126495e-01 | 0.290 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 5.126495e-01 | 0.290 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 5.126495e-01 | 0.290 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 5.126495e-01 | 0.290 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.126495e-01 | 0.290 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 5.126495e-01 | 0.290 |
| R-HSA-163685 | Integration of energy metabolism | 5.184100e-01 | 0.285 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.211636e-01 | 0.283 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 5.213396e-01 | 0.283 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.213396e-01 | 0.283 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 5.213396e-01 | 0.283 |
| R-HSA-392518 | Signal amplification | 5.213396e-01 | 0.283 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.248778e-01 | 0.280 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 5.298753e-01 | 0.276 |
| R-HSA-381042 | PERK regulates gene expression | 5.298753e-01 | 0.276 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 5.382593e-01 | 0.269 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 5.382593e-01 | 0.269 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 5.382593e-01 | 0.269 |
| R-HSA-111933 | Calmodulin induced events | 5.382593e-01 | 0.269 |
| R-HSA-111997 | CaM pathway | 5.382593e-01 | 0.269 |
| R-HSA-74158 | RNA Polymerase III Transcription | 5.382593e-01 | 0.269 |
| R-HSA-9609690 | HCMV Early Events | 5.395947e-01 | 0.268 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 5.464943e-01 | 0.262 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 5.464943e-01 | 0.262 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 5.464943e-01 | 0.262 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 5.464943e-01 | 0.262 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 5.464943e-01 | 0.262 |
| R-HSA-419037 | NCAM1 interactions | 5.464943e-01 | 0.262 |
| R-HSA-8948216 | Collagen chain trimerization | 5.464943e-01 | 0.262 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 5.484329e-01 | 0.261 |
| R-HSA-2029481 | FCGR activation | 5.522410e-01 | 0.258 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.522410e-01 | 0.258 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 5.545829e-01 | 0.256 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 5.545829e-01 | 0.256 |
| R-HSA-1474290 | Collagen formation | 5.574615e-01 | 0.254 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.625277e-01 | 0.250 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 5.625277e-01 | 0.250 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.625277e-01 | 0.250 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 5.625277e-01 | 0.250 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 5.625277e-01 | 0.250 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 5.647829e-01 | 0.248 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.703313e-01 | 0.244 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 5.703313e-01 | 0.244 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 5.703313e-01 | 0.244 |
| R-HSA-167169 | HIV Transcription Elongation | 5.703313e-01 | 0.244 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 5.703313e-01 | 0.244 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 5.703313e-01 | 0.244 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.703313e-01 | 0.244 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.703313e-01 | 0.244 |
| R-HSA-451927 | Interleukin-2 family signaling | 5.703313e-01 | 0.244 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 5.703313e-01 | 0.244 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 5.703313e-01 | 0.244 |
| R-HSA-71240 | Tryptophan catabolism | 5.703313e-01 | 0.244 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 5.703313e-01 | 0.244 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 5.728627e-01 | 0.242 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.779094e-01 | 0.238 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 5.779962e-01 | 0.238 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 5.779962e-01 | 0.238 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.779962e-01 | 0.238 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.779962e-01 | 0.238 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 5.779962e-01 | 0.238 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 5.779962e-01 | 0.238 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 5.829125e-01 | 0.234 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 5.853785e-01 | 0.233 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 5.855248e-01 | 0.232 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 5.855248e-01 | 0.232 |
| R-HSA-991365 | Activation of GABAB receptors | 5.929195e-01 | 0.227 |
| R-HSA-977444 | GABA B receptor activation | 5.929195e-01 | 0.227 |
| R-HSA-165159 | MTOR signalling | 5.929195e-01 | 0.227 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.929195e-01 | 0.227 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 5.929195e-01 | 0.227 |
| R-HSA-111996 | Ca-dependent events | 5.929195e-01 | 0.227 |
| R-HSA-69306 | DNA Replication | 5.933237e-01 | 0.227 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.976596e-01 | 0.224 |
| R-HSA-397014 | Muscle contraction | 5.994203e-01 | 0.222 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.994203e-01 | 0.222 |
| R-HSA-9710421 | Defective pyroptosis | 6.001828e-01 | 0.222 |
| R-HSA-8854214 | TBC/RABGAPs | 6.001828e-01 | 0.222 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 6.024878e-01 | 0.220 |
| R-HSA-1483255 | PI Metabolism | 6.024878e-01 | 0.220 |
| R-HSA-3214858 | RMTs methylate histone arginines | 6.073169e-01 | 0.217 |
| R-HSA-375280 | Amine ligand-binding receptors | 6.073169e-01 | 0.217 |
| R-HSA-5683826 | Surfactant metabolism | 6.073169e-01 | 0.217 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 6.143241e-01 | 0.212 |
| R-HSA-774815 | Nucleosome assembly | 6.143241e-01 | 0.212 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.143241e-01 | 0.212 |
| R-HSA-9824272 | Somitogenesis | 6.143241e-01 | 0.212 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 6.143241e-01 | 0.212 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 6.143241e-01 | 0.212 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 6.143241e-01 | 0.212 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 6.143241e-01 | 0.212 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 6.143241e-01 | 0.212 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.143241e-01 | 0.212 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.143241e-01 | 0.212 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.167101e-01 | 0.210 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.167101e-01 | 0.210 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.212068e-01 | 0.207 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 6.212068e-01 | 0.207 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.212068e-01 | 0.207 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 6.212068e-01 | 0.207 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 6.212068e-01 | 0.207 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 6.212068e-01 | 0.207 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 6.212068e-01 | 0.207 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 6.213636e-01 | 0.207 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 6.279670e-01 | 0.202 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 6.279670e-01 | 0.202 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 6.279670e-01 | 0.202 |
| R-HSA-211000 | Gene Silencing by RNA | 6.305399e-01 | 0.200 |
| R-HSA-2672351 | Stimuli-sensing channels | 6.350629e-01 | 0.197 |
| R-HSA-2467813 | Separation of Sister Chromatids | 6.352352e-01 | 0.197 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 6.395426e-01 | 0.194 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 6.395426e-01 | 0.194 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 6.411289e-01 | 0.193 |
| R-HSA-202403 | TCR signaling | 6.439791e-01 | 0.191 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 6.439791e-01 | 0.191 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 6.439791e-01 | 0.191 |
| R-HSA-109704 | PI3K Cascade | 6.475347e-01 | 0.189 |
| R-HSA-9748787 | Azathioprine ADME | 6.475347e-01 | 0.189 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 6.538266e-01 | 0.185 |
| R-HSA-912446 | Meiotic recombination | 6.538266e-01 | 0.185 |
| R-HSA-5663205 | Infectious disease | 6.568029e-01 | 0.183 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 6.600066e-01 | 0.180 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 6.600066e-01 | 0.180 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 6.600066e-01 | 0.180 |
| R-HSA-6794361 | Neurexins and neuroligins | 6.600066e-01 | 0.180 |
| R-HSA-72306 | tRNA processing | 6.603002e-01 | 0.180 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 6.655176e-01 | 0.177 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 6.660766e-01 | 0.176 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 6.660766e-01 | 0.176 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 6.660766e-01 | 0.176 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 6.660766e-01 | 0.176 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 6.660766e-01 | 0.176 |
| R-HSA-8956320 | Nucleotide biosynthesis | 6.660766e-01 | 0.176 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 6.696975e-01 | 0.174 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 6.720387e-01 | 0.173 |
| R-HSA-156588 | Glucuronidation | 6.720387e-01 | 0.173 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 6.774306e-01 | 0.169 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 6.778946e-01 | 0.169 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.778946e-01 | 0.169 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.778946e-01 | 0.169 |
| R-HSA-418597 | G alpha (z) signalling events | 6.778946e-01 | 0.169 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.819846e-01 | 0.166 |
| R-HSA-2980736 | Peptide hormone metabolism | 6.819846e-01 | 0.166 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 6.836463e-01 | 0.165 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 6.836463e-01 | 0.165 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 6.836463e-01 | 0.165 |
| R-HSA-75893 | TNF signaling | 6.836463e-01 | 0.165 |
| R-HSA-112399 | IRS-mediated signalling | 6.892957e-01 | 0.162 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 6.892957e-01 | 0.162 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 6.977849e-01 | 0.156 |
| R-HSA-72766 | Translation | 6.993643e-01 | 0.155 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.002946e-01 | 0.155 |
| R-HSA-191859 | snRNP Assembly | 7.002946e-01 | 0.155 |
| R-HSA-186712 | Regulation of beta-cell development | 7.002946e-01 | 0.155 |
| R-HSA-352230 | Amino acid transport across the plasma membrane | 7.002946e-01 | 0.155 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 7.035007e-01 | 0.153 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.054390e-01 | 0.152 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.056476e-01 | 0.151 |
| R-HSA-977443 | GABA receptor activation | 7.056476e-01 | 0.151 |
| R-HSA-8873719 | RAB geranylgeranylation | 7.056476e-01 | 0.151 |
| R-HSA-983189 | Kinesins | 7.056476e-01 | 0.151 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 7.056476e-01 | 0.151 |
| R-HSA-351202 | Metabolism of polyamines | 7.056476e-01 | 0.151 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 7.056476e-01 | 0.151 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 7.056476e-01 | 0.151 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 7.056476e-01 | 0.151 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 7.056476e-01 | 0.151 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 7.056476e-01 | 0.151 |
| R-HSA-9679506 | SARS-CoV Infections | 7.083371e-01 | 0.150 |
| R-HSA-162909 | Host Interactions of HIV factors | 7.092053e-01 | 0.149 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 7.109054e-01 | 0.148 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 7.109054e-01 | 0.148 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.109054e-01 | 0.148 |
| R-HSA-445717 | Aquaporin-mediated transport | 7.109054e-01 | 0.148 |
| R-HSA-112043 | PLC beta mediated events | 7.109054e-01 | 0.148 |
| R-HSA-168249 | Innate Immune System | 7.119755e-01 | 0.148 |
| R-HSA-69275 | G2/M Transition | 7.128548e-01 | 0.147 |
| R-HSA-1643685 | Disease | 7.128790e-01 | 0.147 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 7.130131e-01 | 0.147 |
| R-HSA-9609646 | HCMV Infection | 7.149661e-01 | 0.146 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.160696e-01 | 0.145 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 7.160696e-01 | 0.145 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 7.160696e-01 | 0.145 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 7.189640e-01 | 0.143 |
| R-HSA-5617833 | Cilium Assembly | 7.249723e-01 | 0.140 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.261238e-01 | 0.139 |
| R-HSA-5688426 | Deubiquitination | 7.281903e-01 | 0.138 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 7.312597e-01 | 0.136 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.382019e-01 | 0.132 |
| R-HSA-112040 | G-protein mediated events | 7.405437e-01 | 0.130 |
| R-HSA-9830369 | Kidney development | 7.405437e-01 | 0.130 |
| R-HSA-9958863 | SLC-mediated transport of amino acids | 7.405437e-01 | 0.130 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.446972e-01 | 0.128 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 7.446972e-01 | 0.128 |
| R-HSA-167172 | Transcription of the HIV genome | 7.451801e-01 | 0.128 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 7.451801e-01 | 0.128 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.483916e-01 | 0.126 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.523638e-01 | 0.124 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.535205e-01 | 0.123 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 7.542068e-01 | 0.123 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 7.542068e-01 | 0.123 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 7.542068e-01 | 0.123 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 7.542068e-01 | 0.123 |
| R-HSA-9824446 | Viral Infection Pathways | 7.558618e-01 | 0.122 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 7.585999e-01 | 0.120 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 7.585999e-01 | 0.120 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 7.585999e-01 | 0.120 |
| R-HSA-3000178 | ECM proteoglycans | 7.585999e-01 | 0.120 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 7.629148e-01 | 0.118 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 7.641668e-01 | 0.117 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 7.671528e-01 | 0.115 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 7.671528e-01 | 0.115 |
| R-HSA-388396 | GPCR downstream signalling | 7.684810e-01 | 0.114 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 7.713153e-01 | 0.113 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 7.713153e-01 | 0.113 |
| R-HSA-6805567 | Keratinization | 7.720569e-01 | 0.112 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 7.754036e-01 | 0.110 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 7.754036e-01 | 0.110 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 7.794191e-01 | 0.108 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.794191e-01 | 0.108 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 7.823384e-01 | 0.107 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 7.872368e-01 | 0.104 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 7.872368e-01 | 0.104 |
| R-HSA-73864 | RNA Polymerase I Transcription | 7.872368e-01 | 0.104 |
| R-HSA-191273 | Cholesterol biosynthesis | 7.872368e-01 | 0.104 |
| R-HSA-216083 | Integrin cell surface interactions | 7.872368e-01 | 0.104 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.894419e-01 | 0.103 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 7.937619e-01 | 0.100 |
| R-HSA-392499 | Metabolism of proteins | 7.979739e-01 | 0.098 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 7.984485e-01 | 0.098 |
| R-HSA-977225 | Amyloid fiber formation | 7.984485e-01 | 0.098 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 8.020533e-01 | 0.096 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 8.090714e-01 | 0.092 |
| R-HSA-9609507 | Protein localization | 8.124855e-01 | 0.090 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 8.124868e-01 | 0.090 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.191362e-01 | 0.087 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 8.191362e-01 | 0.087 |
| R-HSA-162906 | HIV Infection | 8.209222e-01 | 0.086 |
| R-HSA-162587 | HIV Life Cycle | 8.224923e-01 | 0.085 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.250771e-01 | 0.084 |
| R-HSA-877300 | Interferon gamma signaling | 8.273143e-01 | 0.082 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.296810e-01 | 0.081 |
| R-HSA-5633007 | Regulation of TP53 Activity | 8.296810e-01 | 0.081 |
| R-HSA-202424 | Downstream TCR signaling | 8.317381e-01 | 0.080 |
| R-HSA-112310 | Neurotransmitter release cycle | 8.317381e-01 | 0.080 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 8.347494e-01 | 0.078 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 8.408846e-01 | 0.075 |
| R-HSA-5619102 | SLC transporter disorders | 8.454468e-01 | 0.073 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 8.490191e-01 | 0.071 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 8.543769e-01 | 0.068 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.543769e-01 | 0.068 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.558863e-01 | 0.068 |
| R-HSA-5689880 | Ub-specific processing proteases | 8.598794e-01 | 0.066 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.619994e-01 | 0.064 |
| R-HSA-5610787 | Hedgehog 'off' state | 8.645308e-01 | 0.063 |
| R-HSA-1280218 | Adaptive Immune System | 8.663959e-01 | 0.062 |
| R-HSA-8957322 | Metabolism of steroids | 8.664270e-01 | 0.062 |
| R-HSA-372790 | Signaling by GPCR | 8.675759e-01 | 0.062 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 8.693399e-01 | 0.061 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 8.702545e-01 | 0.060 |
| R-HSA-112316 | Neuronal System | 8.738918e-01 | 0.059 |
| R-HSA-111885 | Opioid Signalling | 8.739789e-01 | 0.058 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 8.739789e-01 | 0.058 |
| R-HSA-9833110 | RSV-host interactions | 8.762365e-01 | 0.057 |
| R-HSA-1474244 | Extracellular matrix organization | 8.763471e-01 | 0.057 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.784538e-01 | 0.056 |
| R-HSA-418346 | Platelet homeostasis | 8.806314e-01 | 0.055 |
| R-HSA-69239 | Synthesis of DNA | 8.827702e-01 | 0.054 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.834632e-01 | 0.054 |
| R-HSA-416476 | G alpha (q) signalling events | 8.854560e-01 | 0.053 |
| R-HSA-983712 | Ion channel transport | 8.883590e-01 | 0.051 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.910201e-01 | 0.050 |
| R-HSA-1483249 | Inositol phosphate metabolism | 8.929047e-01 | 0.049 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 8.948243e-01 | 0.048 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.007047e-01 | 0.045 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 9.021659e-01 | 0.045 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 9.021659e-01 | 0.045 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 9.153520e-01 | 0.038 |
| R-HSA-1483257 | Phospholipid metabolism | 9.226546e-01 | 0.035 |
| R-HSA-5576891 | Cardiac conduction | 9.293714e-01 | 0.032 |
| R-HSA-9909396 | Circadian clock | 9.306391e-01 | 0.031 |
| R-HSA-74160 | Gene expression (Transcription) | 9.329843e-01 | 0.030 |
| R-HSA-597592 | Post-translational protein modification | 9.341308e-01 | 0.030 |
| R-HSA-5358351 | Signaling by Hedgehog | 9.389007e-01 | 0.027 |
| R-HSA-6807070 | PTEN Regulation | 9.399979e-01 | 0.027 |
| R-HSA-212436 | Generic Transcription Pathway | 9.422899e-01 | 0.026 |
| R-HSA-15869 | Metabolism of nucleotides | 9.447775e-01 | 0.025 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 9.461812e-01 | 0.024 |
| R-HSA-157118 | Signaling by NOTCH | 9.479915e-01 | 0.023 |
| R-HSA-418594 | G alpha (i) signalling events | 9.496996e-01 | 0.022 |
| R-HSA-69242 | S Phase | 9.499463e-01 | 0.022 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.517292e-01 | 0.021 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.517292e-01 | 0.021 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.531923e-01 | 0.021 |
| R-HSA-1989781 | PPARA activates gene expression | 9.559145e-01 | 0.020 |
| R-HSA-9610379 | HCMV Late Events | 9.574855e-01 | 0.019 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 9.574855e-01 | 0.019 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.582499e-01 | 0.019 |
| R-HSA-73857 | RNA Polymerase II Transcription | 9.666039e-01 | 0.015 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.725676e-01 | 0.012 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.800437e-01 | 0.009 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.808714e-01 | 0.008 |
| R-HSA-428157 | Sphingolipid metabolism | 9.812311e-01 | 0.008 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.819018e-01 | 0.008 |
| R-HSA-9748784 | Drug ADME | 9.864756e-01 | 0.006 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.891320e-01 | 0.005 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.907770e-01 | 0.004 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.945407e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.963028e-01 | 0.002 |
| R-HSA-500792 | GPCR ligand binding | 9.989061e-01 | 0.000 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.990652e-01 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 9.997125e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.997602e-01 | 0.000 |
| R-HSA-211859 | Biological oxidations | 9.999514e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999707e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999979e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.888 | 0.001 | 1 | 0.871 |
VRK2 |
0.885 | -0.017 | 1 | 0.926 |
PKR |
0.885 | 0.093 | 1 | 0.896 |
VRK1 |
0.884 | -0.022 | 2 | 0.857 |
TNIK |
0.882 | 0.081 | 3 | 0.882 |
NEK1 |
0.881 | 0.030 | 1 | 0.867 |
MINK |
0.879 | 0.012 | 1 | 0.845 |
TAK1 |
0.878 | -0.100 | 1 | 0.861 |
LKB1 |
0.876 | 0.073 | -3 | 0.818 |
MEKK2 |
0.876 | 0.012 | 2 | 0.837 |
LRRK2 |
0.876 | -0.116 | 2 | 0.869 |
HGK |
0.875 | 0.035 | 3 | 0.878 |
KHS1 |
0.875 | 0.062 | 1 | 0.833 |
TTK |
0.875 | 0.017 | -2 | 0.837 |
EEF2K |
0.875 | 0.029 | 3 | 0.840 |
GCK |
0.875 | -0.006 | 1 | 0.840 |
NEK5 |
0.874 | 0.028 | 1 | 0.890 |
PDK1 |
0.874 | -0.032 | 1 | 0.839 |
ASK1 |
0.873 | -0.126 | 1 | 0.809 |
MAP3K15 |
0.873 | -0.031 | 1 | 0.823 |
MEKK6 |
0.873 | 0.004 | 1 | 0.863 |
BMPR2 |
0.873 | -0.043 | -2 | 0.900 |
MYO3B |
0.873 | 0.041 | 2 | 0.854 |
KHS2 |
0.873 | 0.077 | 1 | 0.837 |
TAO2 |
0.872 | -0.057 | 2 | 0.874 |
BRAF |
0.872 | -0.082 | -4 | 0.844 |
MEK1 |
0.871 | -0.155 | 2 | 0.863 |
NIK |
0.871 | -0.037 | -3 | 0.844 |
DAPK2 |
0.870 | 0.015 | -3 | 0.837 |
MST2 |
0.870 | -0.065 | 1 | 0.859 |
MPSK1 |
0.870 | 0.102 | 1 | 0.823 |
MST3 |
0.869 | 0.047 | 2 | 0.871 |
OSR1 |
0.869 | -0.018 | 2 | 0.834 |
MEK5 |
0.869 | -0.194 | 2 | 0.848 |
TAO3 |
0.869 | 0.015 | 1 | 0.852 |
NEK4 |
0.869 | -0.031 | 1 | 0.856 |
CAMLCK |
0.868 | 0.025 | -2 | 0.880 |
CAMKK2 |
0.868 | -0.071 | -2 | 0.784 |
HPK1 |
0.868 | -0.005 | 1 | 0.827 |
PRP4 |
0.868 | 0.229 | -3 | 0.851 |
YSK1 |
0.867 | -0.016 | 2 | 0.847 |
CAMKK1 |
0.867 | -0.093 | -2 | 0.790 |
BIKE |
0.866 | -0.005 | 1 | 0.738 |
MEKK1 |
0.866 | -0.071 | 1 | 0.870 |
MYO3A |
0.866 | -0.056 | 1 | 0.841 |
PRPK |
0.866 | -0.019 | -1 | 0.875 |
MOS |
0.865 | 0.103 | 1 | 0.905 |
MST1 |
0.865 | -0.146 | 1 | 0.847 |
ALK4 |
0.865 | -0.022 | -2 | 0.833 |
MEK2 |
0.864 | -0.174 | 2 | 0.838 |
PBK |
0.863 | 0.013 | 1 | 0.800 |
NEK8 |
0.863 | -0.121 | 2 | 0.841 |
NLK |
0.862 | 0.071 | 1 | 0.872 |
ATR |
0.862 | 0.081 | 1 | 0.895 |
ANKRD3 |
0.862 | -0.122 | 1 | 0.902 |
CAMK1B |
0.860 | -0.008 | -3 | 0.831 |
CDKL1 |
0.860 | 0.060 | -3 | 0.782 |
STLK3 |
0.860 | -0.180 | 1 | 0.811 |
ALPHAK3 |
0.859 | -0.120 | -1 | 0.774 |
JNK2 |
0.859 | 0.105 | 1 | 0.644 |
DMPK1 |
0.859 | 0.055 | -3 | 0.720 |
NEK11 |
0.859 | -0.173 | 1 | 0.839 |
ROCK2 |
0.859 | 0.075 | -3 | 0.748 |
ICK |
0.858 | 0.067 | -3 | 0.815 |
DLK |
0.858 | -0.202 | 1 | 0.880 |
MLK2 |
0.858 | 0.022 | 2 | 0.852 |
P38A |
0.858 | 0.089 | 1 | 0.750 |
YSK4 |
0.857 | -0.081 | 1 | 0.826 |
JNK3 |
0.857 | 0.082 | 1 | 0.684 |
MEKK3 |
0.857 | -0.120 | 1 | 0.858 |
ZAK |
0.856 | -0.112 | 1 | 0.835 |
DAPK3 |
0.856 | 0.017 | -3 | 0.760 |
AAK1 |
0.856 | 0.044 | 1 | 0.627 |
ERK5 |
0.856 | 0.187 | 1 | 0.885 |
LOK |
0.856 | -0.036 | -2 | 0.793 |
SKMLCK |
0.855 | 0.109 | -2 | 0.891 |
ALK2 |
0.855 | -0.023 | -2 | 0.814 |
P38B |
0.855 | 0.106 | 1 | 0.681 |
LATS1 |
0.855 | -0.002 | -3 | 0.815 |
PERK |
0.855 | -0.057 | -2 | 0.849 |
TGFBR1 |
0.855 | 0.021 | -2 | 0.802 |
SMMLCK |
0.854 | -0.039 | -3 | 0.785 |
BMPR1B |
0.854 | 0.094 | 1 | 0.800 |
PASK |
0.853 | -0.054 | -3 | 0.818 |
BUB1 |
0.851 | 0.127 | -5 | 0.777 |
NEK9 |
0.851 | -0.026 | 2 | 0.872 |
TLK2 |
0.850 | 0.016 | 1 | 0.850 |
RAF1 |
0.850 | -0.098 | 1 | 0.885 |
TAO1 |
0.849 | -0.075 | 1 | 0.789 |
ACVR2B |
0.849 | -0.001 | -2 | 0.811 |
ACVR2A |
0.849 | -0.005 | -2 | 0.799 |
WNK4 |
0.848 | -0.065 | -2 | 0.895 |
HRI |
0.847 | -0.158 | -2 | 0.867 |
MLK1 |
0.847 | -0.039 | 2 | 0.842 |
CHAK2 |
0.847 | 0.039 | -1 | 0.814 |
HIPK1 |
0.847 | 0.116 | 1 | 0.753 |
NEK2 |
0.847 | -0.010 | 2 | 0.849 |
NEK3 |
0.846 | -0.061 | 1 | 0.828 |
COT |
0.846 | 0.136 | 2 | 0.889 |
IRAK4 |
0.845 | -0.050 | 1 | 0.865 |
WNK1 |
0.845 | 0.029 | -2 | 0.906 |
TSSK2 |
0.844 | 0.021 | -5 | 0.837 |
CDKL5 |
0.844 | 0.124 | -3 | 0.778 |
PKCD |
0.844 | 0.081 | 2 | 0.820 |
MAK |
0.843 | 0.138 | -2 | 0.750 |
PDHK1 |
0.842 | -0.137 | 1 | 0.896 |
ROCK1 |
0.842 | 0.029 | -3 | 0.712 |
PDHK4 |
0.841 | -0.236 | 1 | 0.905 |
PLK1 |
0.841 | -0.091 | -2 | 0.827 |
AMPKA1 |
0.841 | 0.028 | -3 | 0.815 |
GRK7 |
0.841 | 0.055 | 1 | 0.807 |
P38D |
0.841 | 0.110 | 1 | 0.587 |
DAPK1 |
0.841 | -0.018 | -3 | 0.746 |
HASPIN |
0.841 | -0.014 | -1 | 0.672 |
RIPK1 |
0.840 | -0.160 | 1 | 0.869 |
P38G |
0.840 | 0.079 | 1 | 0.564 |
MASTL |
0.840 | -0.258 | -2 | 0.832 |
PKN3 |
0.840 | -0.007 | -3 | 0.794 |
RIPK3 |
0.840 | -0.027 | 3 | 0.773 |
CLK3 |
0.840 | 0.189 | 1 | 0.874 |
GRK5 |
0.839 | -0.138 | -3 | 0.820 |
DSTYK |
0.839 | 0.011 | 2 | 0.908 |
DYRK2 |
0.839 | 0.118 | 1 | 0.736 |
SLK |
0.839 | -0.102 | -2 | 0.727 |
CAMK2G |
0.839 | -0.108 | 2 | 0.829 |
TLK1 |
0.839 | -0.141 | -2 | 0.842 |
BMPR1A |
0.839 | 0.026 | 1 | 0.774 |
HIPK3 |
0.839 | 0.088 | 1 | 0.762 |
PIM3 |
0.838 | 0.070 | -3 | 0.801 |
GRK6 |
0.838 | -0.084 | 1 | 0.868 |
PIM1 |
0.838 | 0.062 | -3 | 0.747 |
ERK7 |
0.838 | 0.082 | 2 | 0.584 |
MOK |
0.838 | 0.101 | 1 | 0.786 |
TSSK1 |
0.838 | 0.057 | -3 | 0.838 |
MST4 |
0.838 | 0.054 | 2 | 0.879 |
CDC7 |
0.837 | 0.044 | 1 | 0.867 |
MLK3 |
0.837 | -0.000 | 2 | 0.778 |
ERK2 |
0.836 | -0.004 | 1 | 0.715 |
CDK5 |
0.836 | 0.087 | 1 | 0.718 |
MRCKB |
0.836 | 0.037 | -3 | 0.699 |
DCAMKL1 |
0.836 | -0.020 | -3 | 0.746 |
ERK1 |
0.836 | 0.069 | 1 | 0.663 |
NUAK2 |
0.835 | 0.007 | -3 | 0.801 |
PIM2 |
0.835 | 0.035 | -3 | 0.716 |
HIPK4 |
0.835 | 0.164 | 1 | 0.833 |
MLK4 |
0.835 | -0.050 | 2 | 0.753 |
CRIK |
0.835 | 0.024 | -3 | 0.677 |
PKN2 |
0.834 | 0.004 | -3 | 0.796 |
DNAPK |
0.834 | 0.048 | 1 | 0.767 |
P70S6KB |
0.834 | 0.013 | -3 | 0.761 |
SGK3 |
0.834 | 0.069 | -3 | 0.727 |
TGFBR2 |
0.833 | -0.010 | -2 | 0.805 |
ULK2 |
0.833 | -0.049 | 2 | 0.808 |
MARK4 |
0.833 | 0.022 | 4 | 0.853 |
PINK1 |
0.833 | -0.149 | 1 | 0.861 |
NEK6 |
0.833 | 0.069 | -2 | 0.883 |
NEK7 |
0.833 | -0.064 | -3 | 0.813 |
SMG1 |
0.832 | 0.015 | 1 | 0.851 |
IRE1 |
0.832 | 0.001 | 1 | 0.855 |
MTOR |
0.832 | -0.052 | 1 | 0.845 |
MRCKA |
0.831 | -0.005 | -3 | 0.711 |
CHAK1 |
0.831 | -0.112 | 2 | 0.802 |
DYRK1A |
0.831 | 0.055 | 1 | 0.779 |
JNK1 |
0.831 | 0.035 | 1 | 0.625 |
CHK1 |
0.831 | -0.083 | -3 | 0.784 |
TBK1 |
0.831 | -0.041 | 1 | 0.791 |
HUNK |
0.831 | -0.116 | 2 | 0.827 |
AMPKA2 |
0.829 | 0.025 | -3 | 0.780 |
IRE2 |
0.829 | -0.020 | 2 | 0.771 |
PKCA |
0.829 | 0.070 | 2 | 0.766 |
AKT2 |
0.829 | 0.064 | -3 | 0.661 |
SRPK1 |
0.829 | 0.142 | -3 | 0.735 |
SRPK3 |
0.827 | 0.091 | -3 | 0.699 |
CAMK2D |
0.827 | -0.017 | -3 | 0.807 |
PKCZ |
0.827 | 0.020 | 2 | 0.816 |
WNK3 |
0.827 | -0.220 | 1 | 0.873 |
ATM |
0.826 | -0.001 | 1 | 0.830 |
CDK1 |
0.826 | 0.056 | 1 | 0.651 |
CDK14 |
0.826 | 0.039 | 1 | 0.672 |
RSK2 |
0.825 | 0.078 | -3 | 0.749 |
MYLK4 |
0.825 | -0.020 | -2 | 0.809 |
CLK4 |
0.825 | 0.052 | -3 | 0.736 |
DCAMKL2 |
0.824 | -0.106 | -3 | 0.770 |
PKCB |
0.824 | 0.065 | 2 | 0.777 |
DYRK3 |
0.824 | 0.075 | 1 | 0.758 |
DRAK1 |
0.824 | -0.145 | 1 | 0.776 |
PAK1 |
0.824 | 0.001 | -2 | 0.811 |
PKCH |
0.824 | -0.015 | 2 | 0.758 |
MELK |
0.823 | -0.035 | -3 | 0.766 |
PLK3 |
0.823 | -0.133 | 2 | 0.775 |
IKKE |
0.823 | -0.064 | 1 | 0.782 |
PAK2 |
0.823 | -0.064 | -2 | 0.794 |
TTBK2 |
0.823 | -0.138 | 2 | 0.734 |
P90RSK |
0.823 | 0.035 | -3 | 0.756 |
CDK6 |
0.822 | 0.031 | 1 | 0.650 |
HIPK2 |
0.822 | 0.129 | 1 | 0.638 |
SGK1 |
0.822 | 0.049 | -3 | 0.583 |
GRK2 |
0.822 | -0.117 | -2 | 0.725 |
CDK4 |
0.821 | 0.027 | 1 | 0.633 |
PRKD1 |
0.821 | 0.119 | -3 | 0.802 |
GRK1 |
0.821 | 0.056 | -2 | 0.796 |
IRAK1 |
0.821 | -0.278 | -1 | 0.750 |
SSTK |
0.821 | 0.007 | 4 | 0.824 |
CDK13 |
0.820 | 0.050 | 1 | 0.674 |
CDK18 |
0.820 | 0.099 | 1 | 0.627 |
GSK3B |
0.820 | -0.054 | 4 | 0.409 |
PRKD3 |
0.820 | 0.031 | -3 | 0.713 |
AURB |
0.820 | 0.046 | -2 | 0.695 |
PAK3 |
0.820 | -0.025 | -2 | 0.810 |
NDR1 |
0.819 | 0.002 | -3 | 0.794 |
MAPKAPK3 |
0.819 | -0.000 | -3 | 0.740 |
AKT1 |
0.819 | 0.049 | -3 | 0.674 |
CHK2 |
0.819 | -0.025 | -3 | 0.606 |
DYRK1B |
0.819 | 0.040 | 1 | 0.681 |
IKKB |
0.819 | -0.035 | -2 | 0.771 |
NIM1 |
0.819 | -0.029 | 3 | 0.799 |
GSK3A |
0.818 | 0.000 | 4 | 0.416 |
CDK12 |
0.818 | 0.052 | 1 | 0.647 |
QIK |
0.818 | -0.086 | -3 | 0.791 |
PKG2 |
0.817 | 0.079 | -2 | 0.728 |
CDK17 |
0.817 | 0.048 | 1 | 0.569 |
PKCG |
0.817 | 0.011 | 2 | 0.770 |
CAMK4 |
0.816 | -0.136 | -3 | 0.771 |
CDK8 |
0.816 | 0.038 | 1 | 0.691 |
QSK |
0.816 | 0.016 | 4 | 0.832 |
MARK2 |
0.816 | -0.025 | 4 | 0.756 |
CDK7 |
0.816 | 0.028 | 1 | 0.700 |
PKCE |
0.815 | 0.030 | 2 | 0.757 |
CDK2 |
0.815 | -0.038 | 1 | 0.739 |
PKCT |
0.815 | 0.005 | 2 | 0.767 |
CDK3 |
0.815 | 0.070 | 1 | 0.588 |
PKACG |
0.814 | 0.041 | -2 | 0.786 |
GRK4 |
0.814 | -0.139 | -2 | 0.840 |
MNK2 |
0.814 | 0.064 | -2 | 0.826 |
DYRK4 |
0.814 | 0.080 | 1 | 0.651 |
RSK3 |
0.814 | 0.045 | -3 | 0.742 |
GCN2 |
0.814 | -0.088 | 2 | 0.836 |
PKCI |
0.814 | -0.017 | 2 | 0.782 |
CAMK2B |
0.814 | -0.020 | 2 | 0.797 |
CDK16 |
0.814 | 0.059 | 1 | 0.590 |
CLK1 |
0.814 | 0.057 | -3 | 0.715 |
RIPK2 |
0.814 | -0.303 | 1 | 0.796 |
PLK4 |
0.813 | -0.085 | 2 | 0.630 |
CAMK1D |
0.813 | -0.048 | -3 | 0.645 |
CDK9 |
0.813 | 0.015 | 1 | 0.682 |
MNK1 |
0.812 | 0.027 | -2 | 0.836 |
ULK1 |
0.812 | -0.160 | -3 | 0.796 |
AURC |
0.812 | 0.113 | -2 | 0.700 |
PRKD2 |
0.812 | 0.091 | -3 | 0.744 |
PLK2 |
0.811 | -0.062 | -3 | 0.778 |
PDHK3_TYR |
0.811 | 0.142 | 4 | 0.897 |
IKKA |
0.810 | -0.000 | -2 | 0.754 |
BCKDK |
0.809 | -0.124 | -1 | 0.785 |
RSK4 |
0.809 | 0.050 | -3 | 0.712 |
MSK1 |
0.809 | 0.015 | -3 | 0.716 |
CAMK2A |
0.809 | -0.018 | 2 | 0.822 |
MARK1 |
0.808 | -0.077 | 4 | 0.805 |
AURA |
0.808 | 0.023 | -2 | 0.658 |
MARK3 |
0.808 | -0.017 | 4 | 0.785 |
STK33 |
0.808 | -0.191 | 2 | 0.623 |
PKACB |
0.808 | 0.091 | -2 | 0.722 |
CDK10 |
0.807 | 0.052 | 1 | 0.654 |
NDR2 |
0.807 | 0.050 | -3 | 0.800 |
CAMK1G |
0.806 | -0.092 | -3 | 0.722 |
MSK2 |
0.805 | -0.030 | -3 | 0.715 |
SRPK2 |
0.805 | 0.104 | -3 | 0.653 |
LATS2 |
0.804 | -0.024 | -5 | 0.731 |
SIK |
0.804 | -0.008 | -3 | 0.716 |
P70S6K |
0.804 | -0.031 | -3 | 0.674 |
SBK |
0.804 | -0.003 | -3 | 0.547 |
NUAK1 |
0.803 | -0.057 | -3 | 0.746 |
CLK2 |
0.803 | 0.135 | -3 | 0.719 |
PKMYT1_TYR |
0.803 | 0.011 | 3 | 0.871 |
MAP2K4_TYR |
0.803 | -0.012 | -1 | 0.880 |
PHKG1 |
0.802 | -0.058 | -3 | 0.784 |
TESK1_TYR |
0.802 | -0.061 | 3 | 0.890 |
CDK19 |
0.802 | 0.042 | 1 | 0.649 |
LIMK2_TYR |
0.801 | 0.082 | -3 | 0.864 |
MAPKAPK2 |
0.801 | 0.022 | -3 | 0.696 |
AKT3 |
0.800 | 0.059 | -3 | 0.603 |
CAMK1A |
0.800 | -0.037 | -3 | 0.620 |
PDHK4_TYR |
0.800 | -0.020 | 2 | 0.888 |
PAK6 |
0.800 | 0.085 | -2 | 0.737 |
MAP2K7_TYR |
0.799 | -0.164 | 2 | 0.870 |
CK1D |
0.799 | -0.043 | -3 | 0.459 |
MAP2K6_TYR |
0.799 | -0.061 | -1 | 0.865 |
ABL2 |
0.798 | 0.134 | -1 | 0.831 |
PKACA |
0.797 | 0.063 | -2 | 0.675 |
EPHA6 |
0.796 | 0.035 | -1 | 0.842 |
PDHK1_TYR |
0.796 | -0.091 | -1 | 0.874 |
BMPR2_TYR |
0.796 | -0.068 | -1 | 0.848 |
GRK3 |
0.796 | -0.097 | -2 | 0.677 |
PKN1 |
0.796 | -0.027 | -3 | 0.692 |
RET |
0.795 | -0.049 | 1 | 0.871 |
TTBK1 |
0.795 | -0.189 | 2 | 0.638 |
PINK1_TYR |
0.795 | -0.201 | 1 | 0.894 |
EPHB4 |
0.794 | 0.027 | -1 | 0.825 |
MST1R |
0.794 | -0.057 | 3 | 0.849 |
ABL1 |
0.794 | 0.109 | -1 | 0.833 |
TYK2 |
0.794 | -0.072 | 1 | 0.869 |
JAK2 |
0.794 | -0.024 | 1 | 0.865 |
TYRO3 |
0.793 | -0.026 | 3 | 0.832 |
ROS1 |
0.793 | -0.024 | 3 | 0.806 |
TXK |
0.793 | 0.113 | 1 | 0.866 |
BRSK2 |
0.793 | -0.084 | -3 | 0.773 |
CSF1R |
0.792 | -0.010 | 3 | 0.831 |
SNRK |
0.792 | -0.226 | 2 | 0.685 |
KIS |
0.792 | 0.120 | 1 | 0.735 |
CK1A2 |
0.791 | -0.059 | -3 | 0.458 |
LCK |
0.791 | 0.095 | -1 | 0.845 |
YES1 |
0.791 | 0.015 | -1 | 0.867 |
LIMK1_TYR |
0.790 | -0.156 | 2 | 0.868 |
MAPKAPK5 |
0.790 | -0.119 | -3 | 0.685 |
TNK2 |
0.790 | 0.054 | 3 | 0.795 |
BLK |
0.790 | 0.124 | -1 | 0.846 |
BRSK1 |
0.790 | -0.055 | -3 | 0.750 |
FGR |
0.789 | -0.017 | 1 | 0.908 |
HCK |
0.788 | 0.008 | -1 | 0.846 |
CK1E |
0.788 | -0.048 | -3 | 0.512 |
TNNI3K_TYR |
0.788 | 0.091 | 1 | 0.896 |
JAK1 |
0.787 | 0.040 | 1 | 0.808 |
SRMS |
0.786 | -0.009 | 1 | 0.891 |
ITK |
0.785 | 0.005 | -1 | 0.813 |
DDR1 |
0.785 | -0.158 | 4 | 0.825 |
FER |
0.785 | -0.096 | 1 | 0.911 |
PHKG2 |
0.785 | -0.080 | -3 | 0.756 |
FAM20C |
0.785 | 0.009 | 2 | 0.573 |
CK2A2 |
0.785 | 0.004 | 1 | 0.717 |
JAK3 |
0.784 | -0.114 | 1 | 0.847 |
EPHB1 |
0.784 | -0.042 | 1 | 0.895 |
PRKX |
0.783 | 0.097 | -3 | 0.639 |
TNK1 |
0.783 | -0.030 | 3 | 0.816 |
TEC |
0.782 | -0.003 | -1 | 0.787 |
YANK3 |
0.782 | -0.125 | 2 | 0.395 |
KIT |
0.782 | -0.093 | 3 | 0.828 |
EPHB3 |
0.781 | -0.051 | -1 | 0.811 |
BMX |
0.781 | -0.003 | -1 | 0.750 |
PAK5 |
0.781 | 0.000 | -2 | 0.661 |
MERTK |
0.781 | -0.018 | 3 | 0.815 |
AXL |
0.780 | -0.060 | 3 | 0.813 |
EPHB2 |
0.780 | -0.044 | -1 | 0.806 |
INSRR |
0.780 | -0.136 | 3 | 0.775 |
PDGFRB |
0.780 | -0.148 | 3 | 0.836 |
KDR |
0.780 | -0.091 | 3 | 0.796 |
EPHA4 |
0.780 | -0.088 | 2 | 0.768 |
FLT3 |
0.779 | -0.140 | 3 | 0.832 |
MET |
0.779 | -0.063 | 3 | 0.821 |
FYN |
0.779 | 0.031 | -1 | 0.826 |
NEK10_TYR |
0.777 | -0.101 | 1 | 0.734 |
FGFR2 |
0.777 | -0.184 | 3 | 0.819 |
LTK |
0.776 | -0.075 | 3 | 0.775 |
CK2A1 |
0.776 | -0.015 | 1 | 0.694 |
FGFR1 |
0.776 | -0.159 | 3 | 0.801 |
BTK |
0.776 | -0.136 | -1 | 0.793 |
ALK |
0.775 | -0.107 | 3 | 0.750 |
LYN |
0.775 | -0.034 | 3 | 0.759 |
TEK |
0.773 | -0.192 | 3 | 0.765 |
FRK |
0.773 | -0.065 | -1 | 0.852 |
PTK6 |
0.773 | -0.151 | -1 | 0.756 |
WEE1_TYR |
0.773 | -0.102 | -1 | 0.770 |
EPHA1 |
0.773 | -0.073 | 3 | 0.810 |
PDGFRA |
0.773 | -0.214 | 3 | 0.837 |
PKG1 |
0.772 | 0.019 | -2 | 0.648 |
EPHA7 |
0.772 | -0.076 | 2 | 0.771 |
PTK2B |
0.771 | -0.011 | -1 | 0.826 |
YANK2 |
0.770 | -0.154 | 2 | 0.413 |
PAK4 |
0.770 | 0.008 | -2 | 0.665 |
NTRK1 |
0.769 | -0.202 | -1 | 0.812 |
EPHA3 |
0.769 | -0.149 | 2 | 0.742 |
SRC |
0.768 | -0.033 | -1 | 0.834 |
DDR2 |
0.768 | -0.045 | 3 | 0.761 |
NTRK2 |
0.767 | -0.195 | 3 | 0.788 |
FLT1 |
0.767 | -0.160 | -1 | 0.793 |
ERBB2 |
0.767 | -0.194 | 1 | 0.812 |
INSR |
0.766 | -0.175 | 3 | 0.760 |
NTRK3 |
0.765 | -0.134 | -1 | 0.768 |
FGFR3 |
0.764 | -0.203 | 3 | 0.791 |
MATK |
0.764 | -0.127 | -1 | 0.752 |
CK1G1 |
0.764 | -0.049 | -3 | 0.502 |
EPHA5 |
0.763 | -0.111 | 2 | 0.750 |
FLT4 |
0.763 | -0.237 | 3 | 0.786 |
CSK |
0.761 | -0.143 | 2 | 0.773 |
EPHA8 |
0.761 | -0.112 | -1 | 0.785 |
EGFR |
0.759 | -0.111 | 1 | 0.725 |
FGFR4 |
0.757 | -0.127 | -1 | 0.770 |
PTK2 |
0.755 | -0.059 | -1 | 0.740 |
SYK |
0.753 | -0.067 | -1 | 0.743 |
MUSK |
0.752 | -0.156 | 1 | 0.720 |
CK1G3 |
0.752 | -0.068 | -3 | 0.318 |
EPHA2 |
0.752 | -0.118 | -1 | 0.745 |
IGF1R |
0.749 | -0.191 | 3 | 0.695 |
ERBB4 |
0.745 | -0.110 | 1 | 0.731 |
FES |
0.739 | -0.166 | -1 | 0.739 |
ZAP70 |
0.738 | -0.041 | -1 | 0.681 |
CK1A |
0.724 | -0.073 | -3 | 0.368 |
CK1G2 |
0.722 | -0.103 | -3 | 0.414 |