Motif 1084 (n=316)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RU67 | FAM234B | T26 | ochoa | Protein FAM234B | None |
| A6H8Y1 | BDP1 | T915 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| A6H8Y1 | BDP1 | T970 | ochoa | Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) | General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}. |
| O00116 | AGPS | T155 | ochoa | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis. {ECO:0000269|PubMed:8399344, ECO:0000269|PubMed:9553082}. |
| O00151 | PDLIM1 | T34 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00160 | MYO1F | T641 | ochoa | Unconventional myosin-If (Myosin-Ie) | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). {ECO:0000250}. |
| O00311 | CDC7 | T472 | psp | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:27401717}. |
| O00512 | BCL9 | T144 | ochoa | B-cell CLL/lymphoma 9 protein (B-cell lymphoma 9 protein) (Bcl-9) (Protein legless homolog) | Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11955446}. |
| O14607 | UTY | T758 | ochoa | Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY) | Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. {ECO:0000269|PubMed:24798337}. |
| O15117 | FYB1 | T443 | ochoa | FYN-binding protein 1 (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). {ECO:0000250|UniProtKB:D3ZIE4, ECO:0000250|UniProtKB:O35601, ECO:0000269|PubMed:10747096, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:16980616}. |
| O15520 | FGF10 | T114 | psp | Fibroblast growth factor 10 (FGF-10) (Keratinocyte growth factor 2) | Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. {ECO:0000269|PubMed:16597617}. |
| O43166 | SIPA1L1 | T239 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43255 | SIAH2 | T119 | psp | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11483518, PubMed:19224863, PubMed:9334332). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11483518, PubMed:19224863, PubMed:9334332). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (PubMed:22878263). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (PubMed:11483518, PubMed:19224863, PubMed:22878263, PubMed:9334332). Has some overlapping function with SIAH1 (PubMed:11483518, PubMed:19224863, PubMed:9334332). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (PubMed:12411493). Promotes monoubiquitination of SNCA (PubMed:19224863). Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation (PubMed:26392558). Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (PubMed:26392558). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1. {ECO:0000250|UniProtKB:Q06986, ECO:0000269|PubMed:11483518, ECO:0000269|PubMed:12411493, ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:26392558, ECO:0000269|PubMed:28546513, ECO:0000269|PubMed:9334332}. |
| O43318 | MAP3K7 | T184 | psp | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250|UniProtKB:Q62073, ECO:0000269|PubMed:10094049, ECO:0000269|PubMed:11460167, ECO:0000269|PubMed:12589052, ECO:0000269|PubMed:16845370, ECO:0000269|PubMed:16893890, ECO:0000269|PubMed:21512573, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9079627}. |
| O60684 | KPNA6 | T122 | ochoa | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. |
| O60701 | UGDH | T185 | ochoa | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) | Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21502315, PubMed:21961565, PubMed:22123821, PubMed:23106432, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development (PubMed:32001716). {ECO:0000250|UniProtKB:O70475, ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21961565, ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:25478983, ECO:0000269|PubMed:27966912, ECO:0000269|PubMed:30420606, ECO:0000269|PubMed:30457329, ECO:0000269|PubMed:32001716}. |
| O75150 | RNF40 | T574 | ochoa | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269|PubMed:37888983}. |
| O75363 | BCAS1 | T353 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75369 | FLNB | T709 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
| O75762 | TRPA1 | T673 | psp | Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor) | Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization (PubMed:19202543, PubMed:21195050). Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant (PubMed:20547126, PubMed:25389312, PubMed:27241698, PubMed:30878828). Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner (PubMed:17164327, PubMed:27241698, PubMed:31866091, PubMed:32641835). Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation (PubMed:33152265). Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity). {ECO:0000250|UniProtKB:Q8BLA8, ECO:0000269|PubMed:17164327, ECO:0000269|PubMed:17259981, ECO:0000269|PubMed:19202543, ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:21195050, ECO:0000269|PubMed:21873995, ECO:0000269|PubMed:23199233, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:27241698, ECO:0000269|PubMed:30878828, ECO:0000269|PubMed:31866091, ECO:0000269|PubMed:32641835, ECO:0000269|PubMed:33152265}. |
| O75874 | IDH1 | T77 | ochoa | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). {ECO:0000250|UniProtKB:Q9XSG3, ECO:0000269|PubMed:10521434, ECO:0000269|PubMed:19935646, ECO:0000303|PubMed:10521434}. |
| O75874 | IDH1 | T313 | ochoa | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). {ECO:0000250|UniProtKB:Q9XSG3, ECO:0000269|PubMed:10521434, ECO:0000269|PubMed:19935646, ECO:0000303|PubMed:10521434}. |
| O76021 | RSL1D1 | T358 | ochoa | Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1) | Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. |
| O76094 | SRP72 | T602 | ochoa | Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38688, ECO:0000269|PubMed:21073748, ECO:0000269|PubMed:27899666, ECO:0000269|PubMed:34020957}. |
| O94913 | PCF11 | T327 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94986 | CEP152 | T1241 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95359 | TACC2 | T1426 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95359 | TACC2 | T2373 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O95466 | FMNL1 | T1020 | ochoa | Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) | May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O95613 | PCNT | T2155 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| O95696 | BRD1 | T110 | ochoa | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
| O95831 | AIFM1 | T105 | ochoa | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:17094969, PubMed:20362274, PubMed:23217327, PubMed:33168626). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway (PubMed:20362274). Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA (PubMed:20362274). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228). {ECO:0000250|UniProtKB:Q9Z0X1, ECO:0000269|PubMed:17094969, ECO:0000269|PubMed:19418225, ECO:0000269|PubMed:20362274, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:26004228, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:33168626}.; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. {ECO:0000269|PubMed:16644725}.; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. {ECO:0000269|PubMed:16365034}. |
| O95997 | PTTG1 | T60 | psp | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:12355087}. |
| O95999 | BCL10 | T130 | ochoa | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:10187770, PubMed:10364242, PubMed:10400625, PubMed:24074955, PubMed:25365219). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:24074955). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (PubMed:24074955). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:18287044, PubMed:24074955, PubMed:27777308). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:26488816). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (PubMed:18264101, PubMed:18287044, PubMed:24074955, PubMed:27777308). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (PubMed:10187815). {ECO:0000269|PubMed:10187770, ECO:0000269|PubMed:10187815, ECO:0000269|PubMed:10364242, ECO:0000269|PubMed:10400625, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:18287044, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:25365219, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:27777308}. |
| P00533 | EGFR | T725 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P01833 | PIGR | T679 | ochoa | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] | [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}. |
| P02775 | PPBP | T87 | ochoa | Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))] | LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}. |
| P04075 | ALDOA | T123 | ochoa | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269|PubMed:14766013}. |
| P04083 | ANXA1 | T226 | ochoa | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P06400 | RB1 | T252 | ochoa|psp | Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110) | Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250|UniProtKB:P13405, ECO:0000250|UniProtKB:P33568, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269|PubMed:1316611, ECO:0000269|PubMed:17974914, ECO:0000269|PubMed:18701596, ECO:0000269|PubMed:2839300, ECO:0000269|PubMed:8892909}. |
| P06576 | ATP5F1B | T213 | ochoa | ATP synthase F(1) complex subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) | Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (PubMed:37244256). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:25168243, ECO:0000305|PubMed:36239646, ECO:0000305|PubMed:37244256}. |
| P07550 | ADRB2 | T360 | psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P07550 | ADRB2 | T384 | psp | Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. {ECO:0000269|PubMed:2831218, ECO:0000269|PubMed:7915137}. |
| P08908 | HTR1A | T314 | psp | 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A) | G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:38552625, PubMed:8138923, PubMed:8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:8138923, PubMed:8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:33762731, PubMed:35610220). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the response to anxiogenic stimuli (PubMed:18476671, PubMed:20363322, PubMed:20945968). {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:8138923, ECO:0000269|PubMed:8393041, ECO:0000303|PubMed:18476671, ECO:0000303|PubMed:20363322, ECO:0000303|PubMed:20945968}. |
| P0C7T5 | ATXN1L | T369 | ochoa | Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1) | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity). {ECO:0000250|UniProtKB:P0C7T6, ECO:0000269|PubMed:21475249}. |
| P0DKX0 | ZNF728 | T139 | ochoa | Zinc finger protein 728 | None |
| P10244 | MYBL2 | T494 | ochoa | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P10244 | MYBL2 | T505 | ochoa | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P10966 | CD8B | T140 | ochoa | T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b) | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. {ECO:0000250|UniProtKB:P10300, ECO:0000269|PubMed:10925291, ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:17145893}. |
| P11171 | EPB41 | T627 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P11532 | DMD | T3081 | psp | Dystrophin | Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}. |
| P13639 | EEF2 | T54 | ochoa | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P14598 | NCF1 | T138 | psp | Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269|PubMed:12732142, ECO:0000269|PubMed:19801500, ECO:0000269|PubMed:2547247, ECO:0000269|PubMed:2550933, ECO:0000269|PubMed:38355798}. |
| P14867 | GABRA1 | T376 | ochoa | Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) (GABAAR subunit alpha-1) | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725, PubMed:30602789). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725, PubMed:30602789). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:23909897, PubMed:29950725, PubMed:30602789). Alpha-1/GABRA1-containing GABAARs are largely synaptic (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, PubMed:25489750). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P62812, ECO:0000250|UniProtKB:P62813, ECO:0000269|PubMed:23909897, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789}. |
| P15822 | HIVEP1 | T1938 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16144 | ITGB4 | T805 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P18124 | RPL7 | T224 | ochoa | Large ribosomal subunit protein uL30 (60S ribosomal protein L7) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). Binds to G-rich structures in 28S rRNA and in mRNAs (PubMed:12962325). Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (PubMed:12962325). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P19429 | TNNI3 | T129 | psp | Troponin I, cardiac muscle (Cardiac troponin I) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P20929 | NEB | T1871 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P21359 | NF1 | T2564 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P21817 | RYR1 | T1360 | ochoa | Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor) | Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250|UniProtKB:E9PZQ0, ECO:0000269|PubMed:18268335, ECO:0000269|PubMed:18650434, ECO:0000269|PubMed:26115329, ECO:0000305|PubMed:11741831, ECO:0000305|PubMed:16163667}. |
| P25205 | MCM3 | T164 | ochoa | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P26038 | MSN | T526 | ochoa | Moesin (Membrane-organizing extension spike protein) | Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266). These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356). The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160). Modulates phagolysosomal biogenesis in macrophages (By similarity). Also participates in immunologic synapse formation (PubMed:27405666). {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:10212266, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:27405666, ECO:0000269|PubMed:9298994, ECO:0000269|PubMed:9616160}. |
| P26196 | DDX6 | T38 | ochoa | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) | Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:25995375, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:31422817}. |
| P26640 | VARS1 | T284 | ochoa | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | Catalyzes the attachment of valine to tRNA(Val). {ECO:0000269|PubMed:8428657}. |
| P27816 | MAP4 | T76 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P30044 | PRDX5 | T97 | ochoa | Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}. |
| P32004 | L1CAM | T1159 | ochoa | Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. {ECO:0000269|PubMed:20621658, ECO:0000305}. |
| P32241 | VIPR1 | T429 | psp | Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1 receptor) (VPAC1R) | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610). {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}. |
| P35251 | RFC1 | T138 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35348 | ADRA1A | T384 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P35579 | MYH9 | T1800 | ochoa|psp | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P38432 | COIL | T456 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P40818 | USP8 | T585 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P40818 | USP8 | T594 | ochoa | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062). {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:27302062, ECO:0000269|PubMed:9628861}. |
| P42166 | TMPO | T138 | ochoa | Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| P42766 | RPL35 | T64 | ochoa | Large ribosomal subunit protein uL29 (60S ribosomal protein L35) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P43490 | NAMPT | T435 | ochoa | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). {ECO:0000250|UniProtKB:Q99KQ4, ECO:0000269|PubMed:24130902}. |
| P46777 | RPL5 | T232 | ochoa | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| P46821 | MAP1B | T2304 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P48048 | KCNJ1 | T193 | psp | ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:7929082}. |
| P48059 | LIMS1 | T280 | ochoa | LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) | Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration. {ECO:0000269|PubMed:30367047}. |
| P48735 | IDH2 | T352 | ochoa | Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140). {ECO:0000269|PubMed:19228619, ECO:0000269|PubMed:22416140}. |
| P49321 | NASP | T683 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P51805 | PLXNA3 | T1590 | ochoa | Plexin-A3 (Plexin-4) (Semaphorin receptor SEX) | Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
| P53597 | SUCLG1 | T69 | ochoa | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) | Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. {ECO:0000255|HAMAP-Rule:MF_03222, ECO:0000269|PubMed:34492704}. |
| P54132 | BLM | T68 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54132 | BLM | T99 | psp | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54132 | BLM | T359 | ochoa | RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) | ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250|UniProtKB:O88700, ECO:0000269|PubMed:12019152, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639533, ECO:0000269|PubMed:21325134, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:24257077, ECO:0000269|PubMed:24816114, ECO:0000269|PubMed:25901030, ECO:0000269|PubMed:34606619, ECO:0000269|PubMed:9388193, ECO:0000269|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269|PubMed:32690953}. |
| P54198 | HIRA | T586 | ochoa | Protein HIRA (TUP1-like enhancer of split protein 1) | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}. |
| P54278 | PMS2 | T573 | ochoa | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042). {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753, ECO:0000269|PubMed:30653781, ECO:0000269|PubMed:35189042}. |
| P60709 | ACTB | T303 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P60842 | EIF4A1 | T158 | ochoa | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963). {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20156963}. |
| P61764 | STXBP1 | T574 | psp | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000250|UniProtKB:P61765}. |
| P62191 | PSMC1 | T53 | ochoa | 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| P62736 | ACTA2 | T305 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P62753 | RPS6 | T127 | ochoa | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P62826 | RAN | T24 | ochoa | GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein) | GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:11336674, PubMed:26272610, PubMed:29040603, PubMed:7819259, PubMed:8636225, PubMed:8692944, PubMed:8896452, PubMed:9351834, PubMed:9428644, PubMed:9822603). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:12194828, PubMed:29040603, PubMed:8421051). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640). {ECO:0000269|PubMed:10400640, ECO:0000269|PubMed:10408446, ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17209048, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:27306458, ECO:0000269|PubMed:29040603, ECO:0000269|PubMed:7819259, ECO:0000269|PubMed:8276887, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8636225, ECO:0000269|PubMed:8692944, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9428644, ECO:0000269|PubMed:9822603, ECO:0000305|PubMed:26272610}. |
| P63261 | ACTG1 | T303 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | T304 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | T305 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P98170 | XIAP | T180 | ochoa|psp | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis (PubMed:11257230, PubMed:11257231, PubMed:11447297, PubMed:12121969, PubMed:12620238, PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:9230442). Acts as a direct caspase inhibitor (PubMed:11257230, PubMed:11257231, PubMed:12620238). Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry (PubMed:11257230, PubMed:11257231, PubMed:16352606, PubMed:16916640). Inactivates CASP9 by keeping it in a monomeric, inactive state (PubMed:12620238). Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin (PubMed:17560374, PubMed:17967870, PubMed:19473982, PubMed:20154138, PubMed:22103349, PubMed:22607974, PubMed:29452636, PubMed:30026309). Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:19667203, PubMed:22607974, PubMed:29452636, PubMed:30026309). 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 (PubMed:22607974, PubMed:29452636). Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation (PubMed:17560374). Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation (PubMed:20154138). Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation (PubMed:17967870, PubMed:22103349). Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation (PubMed:14685266). Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation (PubMed:21145488). Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis (PubMed:29020630). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner (PubMed:22095281). Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 (PubMed:22095281). Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES (PubMed:22304967). Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program (PubMed:22304967). {ECO:0000269|PubMed:11257230, ECO:0000269|PubMed:11257231, ECO:0000269|PubMed:11447297, ECO:0000269|PubMed:12121969, ECO:0000269|PubMed:12620238, ECO:0000269|PubMed:14685266, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:17560374, ECO:0000269|PubMed:17967870, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:19667203, ECO:0000269|PubMed:20154138, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:22103349, ECO:0000269|PubMed:22304967, ECO:0000269|PubMed:22607974, ECO:0000269|PubMed:29020630, ECO:0000269|PubMed:29452636, ECO:0000269|PubMed:30026309, ECO:0000269|PubMed:9230442, ECO:0000303|PubMed:22095281}. |
| Q00610 | CLTC | T394 | ochoa | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). {ECO:0000250|UniProtKB:P49951, ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. |
| Q02086 | SP2 | T192 | ochoa | Transcription factor Sp2 | Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. |
| Q02818 | NUCB1 | T148 | ochoa | Nucleobindin-1 (CALNUC) | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). {ECO:0000250|UniProtKB:Q0P569, ECO:0000250|UniProtKB:Q63083}. |
| Q04656 | ATP7A | T152 | ochoa|psp | Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein) | ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q64430, ECO:0000269|PubMed:10419525, ECO:0000269|PubMed:11092760, ECO:0000269|PubMed:19453293, ECO:0000269|PubMed:19917612, ECO:0000269|PubMed:28389643, ECO:0000269|PubMed:31283225}. |
| Q06413 | MEF2C | T80 | psp | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15340086, ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:9069290, ECO:0000269|PubMed:9384584}. |
| Q07157 | TJP1 | T772 | psp | Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}. |
| Q09666 | AHNAK | T146 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12846 | STX4 | T120 | ochoa | Syntaxin-4 (Renal carcinoma antigen NY-REN-31) | Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (PubMed:36355422). {ECO:0000250|UniProtKB:P70452, ECO:0000250|UniProtKB:Q08850, ECO:0000269|PubMed:36355422}. |
| Q12888 | TP53BP1 | T100 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | T922 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12913 | PTPRJ | T1315 | ochoa | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:30591527, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}. |
| Q12913 | PTPRJ | T1318 | ochoa|psp | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (PubMed:10821867, PubMed:12062403, PubMed:12370829, PubMed:12475979, PubMed:18348712, PubMed:19494114, PubMed:19922411, PubMed:21262971). Plays a role in cell adhesion, migration, proliferation and differentiation (PubMed:12370829, PubMed:14709717, PubMed:16682945, PubMed:19836242). Has a role in megakaryocytes and platelet formation (PubMed:30591527). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation (PubMed:16682945). Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR (PubMed:21091576). Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation (PubMed:18936167). Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation (PubMed:19836242). Enhances the barrier function of epithelial junctions during reassembly (PubMed:19332538). Negatively regulates T-cell receptor (TCR) signaling (PubMed:11259588, PubMed:9531590, PubMed:9780142). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (PubMed:11259588, PubMed:12913111). {ECO:0000250|UniProtKB:Q64455, ECO:0000269|PubMed:10821867, ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403, ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717, ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114, ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411, ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:30591527, ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}.; FUNCTION: [Isoform 2]: Activates angiogenesis and cell migration (PubMed:28052032). Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 (PubMed:28052032). {ECO:0000269|PubMed:28052032}. |
| Q13153 | PAK1 | T146 | ochoa | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q13155 | AIMP2 | T82 | ochoa | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) | Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:19131329}. |
| Q13428 | TCOF1 | T1358 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q13435 | SF3B2 | T780 | ochoa | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| Q13546 | RIPK1 | T608 | ochoa | Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) | Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). Kinase activity is essential to regulate necroptosis and apoptosis, two parallel forms of cell death: upon activation of its protein kinase activity, regulates assembly of two death-inducing complexes, namely complex IIa (RIPK1-FADD-CASP8), which drives apoptosis, and the complex IIb (RIPK1-RIPK3-MLKL), which drives necroptosis (By similarity). RIPK1 is required to limit CASP8-dependent TNFR1-induced apoptosis (By similarity). In normal conditions, RIPK1 acts as an inhibitor of RIPK3-dependent necroptosis, a process mediated by RIPK3 component of complex IIb, which catalyzes phosphorylation of MLKL upon induction by ZBP1 (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Inhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Required to inhibit apoptosis and necroptosis during embryonic development: acts by preventing the interaction of TRADD with FADD thereby limiting aberrant activation of CASP8 (By similarity). In addition to apoptosis and necroptosis, also involved in inflammatory response by promoting transcriptional production of pro-inflammatory cytokines, such as interleukin-6 (IL6) (PubMed:31827280, PubMed:31827281). Phosphorylates RIPK3: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:15310755, PubMed:17389591). Required for ZBP1-induced NF-kappa-B activation in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:Q60855, ECO:0000269|PubMed:11101870, ECO:0000269|PubMed:15310755, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:24144979, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281, ECO:0000269|PubMed:32657447, ECO:0000269|PubMed:35831301}. |
| Q13554 | CAMK2B | T381 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250|UniProtKB:P08413, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:31930741}. |
| Q14168 | MPP2 | T327 | ochoa | MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) | Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017). {ECO:0000250|UniProtKB:D3ZAA9, ECO:0000250|UniProtKB:Q9WV34, ECO:0000269|PubMed:19665017}. |
| Q14240 | EIF4A2 | T159 | ochoa | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
| Q14315 | FLNC | T2006 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14677 | CLINT1 | T272 | ochoa | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. |
| Q14683 | SMC1A | T946 | ochoa | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}. |
| Q14978 | NOLC1 | T597 | ochoa | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. |
| Q14997 | PSME4 | T1750 | ochoa | Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10) | Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:12093752, ECO:0000269|PubMed:18845680, ECO:0000269|PubMed:22550082, ECO:0000269|PubMed:23706739}. |
| Q15147 | PLCB4 | T886 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) | Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927). {ECO:0000250|UniProtKB:Q07722, ECO:0000269|PubMed:35284927}. |
| Q15303 | ERBB4 | T731 | ochoa | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q15651 | HMGN3 | T75 | ochoa | High mobility group nucleosome-binding domain-containing protein 3 (Thyroid receptor-interacting protein 7) (TR-interacting protein 7) (TRIP-7) | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}. |
| Q15788 | NCOA1 | T789 | psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q15833 | STXBP2 | T94 | ochoa | Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B) | Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. {ECO:0000269|PubMed:19804848, ECO:0000269|PubMed:19884660}. |
| Q15833 | STXBP2 | T572 | psp | Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B) | Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. {ECO:0000269|PubMed:19804848, ECO:0000269|PubMed:19884660}. |
| Q16667 | CDKN3 | T80 | ochoa | Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) | May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954). {ECO:0000269|PubMed:7569954, ECO:0000269|PubMed:8127873, ECO:0000269|PubMed:8242750}. |
| Q2KHR3 | QSER1 | T1256 | ochoa | Glutamine and serine-rich protein 1 | Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269|PubMed:33833093}. |
| Q4G163 | FBXO43 | T234 | psp | F-box only protein 43 (Endogenous meiotic inhibitor 2) | Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis. {ECO:0000250|UniProtKB:Q8CDI2, ECO:0000269|PubMed:34052850, ECO:0000269|PubMed:34595750}. |
| Q53EL6 | PDCD4 | T126 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q5JTV8 | TOR1AIP1 | T286 | ochoa | Torsin-1A-interacting protein 1 (Lamin-associated protein 1B) (LAP1B) | Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:23569223}. |
| Q5QJE6 | DNTTIP2 | T136 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5QJE6 | DNTTIP2 | T232 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5QJE6 | DNTTIP2 | T610 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5S007 | LRRK2 | T1348 | psp | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q5T4S7 | UBR4 | T3383 | ochoa | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (p600) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) | E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180, PubMed:38030679). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:38030679). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR5, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR4 probably synthesizes mixed chains containing multiple linkages, while UBR5 is likely branching multiple 'Lys-48'-linked chains of substrates initially modified (PubMed:29033132). Together with KCMF1, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). Mediates ubiquitination of ACLY, leading to its subsequent degradation (PubMed:23932781). Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization (PubMed:16214886). {ECO:0000269|PubMed:16214886, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:25582440, ECO:0000269|PubMed:29033132, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:37891180, ECO:0000269|PubMed:38030679, ECO:0000269|PubMed:38182926, ECO:0000269|PubMed:38297121}. |
| Q5TCZ1 | SH3PXD2A | T731 | ochoa | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}. |
| Q5U5Q3 | MEX3C | T268 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q5UIP0 | RIF1 | T1388 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VZK9 | CARMIL1 | T1044 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q63HK5 | TSHZ3 | T310 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q641Q2 | WASHC2A | T506 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6IE81 | JADE1 | T739 | ochoa | Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}. |
| Q6N022 | TENM4 | T2580 | ochoa | Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}. |
| Q6P0N0 | MIS18BP1 | T1089 | ochoa | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}. |
| Q6P995 | FAM171B | T406 | ochoa | Protein FAM171B | None |
| Q6PKG0 | LARP1 | T178 | ochoa | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6UB98 | ANKRD12 | T121 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6WCQ1 | MPRIP | T383 | ochoa | Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip) | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. {ECO:0000250|UniProtKB:P97434, ECO:0000269|PubMed:15545284, ECO:0000269|PubMed:16257966}. |
| Q6ZVD7 | STOX1 | T401 | ochoa | Storkhead-box protein 1 (Winged-helix domain-containing protein) | Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:24738702}.; FUNCTION: [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177). {ECO:0000269|PubMed:22253775, ECO:0000269|PubMed:22995177}. |
| Q71F56 | MED13L | T758 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q7L2J0 | MEPCE | T245 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7RTP6 | MICAL3 | T1545 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z2T5 | TRMT1L | T26 | ochoa | tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein) | Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}. |
| Q86SQ0 | PHLDB2 | T898 | ochoa | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) | Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}. |
| Q86UE8 | TLK2 | T78 | ochoa | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q86UP2 | KTN1 | T153 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86UP2 | KTN1 | T268 | ochoa | Kinectin (CG-1 antigen) (Kinesin receptor) | Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. |
| Q86VQ1 | GLCCI1 | T266 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86XN8 | MEX3D | T215 | ochoa | RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO) | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. {ECO:0000250}. |
| Q86YC2 | PALB2 | T757 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IW41 | MAPKAPK5 | T186 | ochoa | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q8IX01 | SUGP2 | T265 | ochoa | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | May play a role in mRNA splicing. {ECO:0000305}. |
| Q8N3R9 | PALS1 | T238 | ochoa | Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) | Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (PubMed:16678097, PubMed:25385611). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (PubMed:27466317). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B (PubMed:21479189). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q9JLB2, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:21479189, ECO:0000269|PubMed:25385611, ECO:0000269|PubMed:27466317}.; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. {ECO:0000269|PubMed:20861307, ECO:0000303|PubMed:32891874}. |
| Q8N4C9 | C17orf78 | T152 | ochoa | Uncharacterized protein C17orf78 | None |
| Q8N7Q3 | ZNF676 | T107 | ochoa | Zinc finger protein 676 | May be involved in transcriptional regulation. |
| Q8N884 | CGAS | T68 | ochoa | Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:21478870, PubMed:23258413, PubMed:23707061, PubMed:23707065, PubMed:23722159, PubMed:24077100, PubMed:24116191, PubMed:24462292, PubMed:25131990, PubMed:26300263, PubMed:29976794, PubMed:30799039, PubMed:31142647, PubMed:32814054, PubMed:33273464, PubMed:33542149, PubMed:37217469, PubMed:37802025). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28214358, PubMed:28363908). Acts as a key DNA sensor: directly binds double-stranded DNA (dsDNA), inducing the formation of liquid-like droplets in which CGAS is activated, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates STING1, thereby triggering type-I interferon production (PubMed:28314590, PubMed:28363908, PubMed:29976794, PubMed:32817552, PubMed:33230297, PubMed:33606975, PubMed:35322803, PubMed:35438208, PubMed:35460603, PubMed:35503863). Preferentially recognizes and binds curved long dsDNAs of a minimal length of 40 bp (PubMed:30007416). Acts as a key foreign DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908, PubMed:35613581). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-2, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945, PubMed:24269171, PubMed:30270045, PubMed:32852081). In contrast, HIV-1 is poorly sensed by CGAS, due to its capsid that cloaks viral DNA from CGAS detection (PubMed:24269171, PubMed:30270045, PubMed:32852081). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). 2',3'-cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote STING1 activation and convey immune response to connecting cells (PubMed:24077100). 2',3'-cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but STING1-dependent manner (PubMed:26229115). Also senses the presence of neutrophil extracellular traps (NETs) that are translocated to the cytosol following phagocytosis, leading to synthesis of 2',3'-cGAMP (PubMed:33688080). In addition to foreign DNA, can also be activated by endogenous nuclear or mitochondrial DNA (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297). When self-DNA leaks into the cytosol during cellular stress (such as mitochondrial stress, SARS-CoV-2 infection causing severe COVID-19 disease, DNA damage, mitotic arrest or senescence), or is present in form of cytosolic micronuclei, CGAS is activated leading to a state of sterile inflammation (PubMed:28738408, PubMed:28759889, PubMed:31299200, PubMed:33031745, PubMed:33230297, PubMed:35045565). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via STING1 and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to 2',3'-cGAMP synthesis and subsequent activation of STING1 and type-I interferon production (PubMed:28738408, PubMed:28759889). Activated in response to prolonged mitotic arrest, promoting mitotic cell death (PubMed:31299200). In a healthy cell, CGAS is however kept inactive even in cellular events that directly expose it to self-DNA, such as mitosis, when cGAS associates with chromatin directly after nuclear envelope breakdown or remains in the form of postmitotic persistent nuclear cGAS pools bound to chromatin (PubMed:31299200, PubMed:33542149). Nuclear CGAS is inactivated by chromatin via direct interaction with nucleosomes, which block CGAS from DNA binding and thus prevent CGAS-induced autoimmunity (PubMed:31299200, PubMed:32911482, PubMed:32912999, PubMed:33051594, PubMed:33542149). Also acts as a suppressor of DNA repair in response to DNA damage: inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214, PubMed:31544964). In addition to DNA, also sense translation stress: in response to translation stress, translocates to the cytosol and associates with collided ribosomes, promoting its activation and triggering type-I interferon production (PubMed:34111399). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less 2',3'-cGAMP, allowing a more fine-tuned response to pathogens (PubMed:30007416). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24269171, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30270045, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:31299200, ECO:0000269|PubMed:31544964, ECO:0000269|PubMed:32814054, ECO:0000269|PubMed:32817552, ECO:0000269|PubMed:32852081, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33031745, ECO:0000269|PubMed:33051594, ECO:0000269|PubMed:33230297, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33542149, ECO:0000269|PubMed:33606975, ECO:0000269|PubMed:33688080, ECO:0000269|PubMed:34111399, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:35438208, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:35503863, ECO:0000269|PubMed:35613581, ECO:0000269|PubMed:37217469, ECO:0000269|PubMed:37802025}. |
| Q8ND24 | RNF214 | T384 | ochoa | RING finger protein 214 | None |
| Q8NEB9 | PIK3C3 | T668 | psp | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435). As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). {ECO:0000250|UniProtKB:O88763, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:32690950, ECO:0000269|PubMed:33637724, ECO:0000269|PubMed:7628435}.; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| Q8NEF9 | SRFBP1 | T199 | ochoa | Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP) | May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}. |
| Q8NEZ4 | KMT2C | T2008 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NFC6 | BOD1L1 | T1351 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NHU6 | TDRD7 | T327 | ochoa | Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap) | Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. {ECO:0000269|PubMed:21436445}. |
| Q8NHV4 | NEDD1 | T303 | psp | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}. |
| Q8NI27 | THOC2 | T1285 | ochoa | THO complex subunit 2 (Tho2) (hTREX120) | Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269|PubMed:11979277, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:22893130, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q8TAA9 | VANGL1 | T322 | ochoa | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | None |
| Q8TF76 | HASPIN | T373 | psp | Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}. |
| Q8WVV4 | POF1B | T114 | ochoa | Protein POF1B (Premature ovarian failure protein 1B) | Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. {ECO:0000269|PubMed:16773570, ECO:0000269|PubMed:21940798}. |
| Q8WW12 | PCNP | T79 | ochoa | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) | May be involved in cell cycle regulation. |
| Q8WWI1 | LMO7 | T117 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q8WXE9 | STON2 | T766 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q8WY36 | BBX | T707 | ochoa | HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) | Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}. |
| Q8WYP5 | AHCTF1 | T1764 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92692 | NECTIN2 | T426 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q92833 | JARID2 | T824 | ochoa | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q92890 | UFD1 | T136 | ochoa | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}. |
| Q92918 | MAP4K1 | T355 | psp | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) | Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:8824585}. |
| Q96AG4 | LRRC59 | T62 | ochoa | Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] | Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}. |
| Q96BY6 | DOCK10 | T202 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96C57 | CUSTOS | T210 | ochoa | Protein CUSTOS | Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}. |
| Q96C57 | CUSTOS | T211 | ochoa | Protein CUSTOS | Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}. |
| Q96FJ0 | STAMBPL1 | T47 | ochoa | AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). {ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100}. |
| Q96G03 | PGM2 | T304 | ochoa | Phosphopentomutase (EC 5.4.2.7) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-2) (EC 5.4.2.2) | Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (PubMed:17804405). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate but with a lower catalytic efficiency (PubMed:17804405). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed:17804405). In vitro, also has a low glucose 1,6-bisphosphate synthase activity which is most probably not physiologically relevant (PubMed:17804405, PubMed:18927083). {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083}. |
| Q96HE9 | PRR11 | T287 | ochoa | Proline-rich protein 11 | Plays a critical role in cell cycle progression. {ECO:0000269|PubMed:23246489}. |
| Q96Q15 | SMG1 | T3573 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96T58 | SPEN | T1826 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99549 | MPHOSPH8 | T454 | ochoa | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
| Q99704 | DOK1 | T406 | ochoa | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}. |
| Q99741 | CDC6 | T37 | psp | Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) | Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. |
| Q99814 | EPAS1 | T406 | psp | Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) | Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P97481}. |
| Q99832 | CCT7 | T332 | psp | T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q9BQ39 | DDX50 | T118 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BTC0 | DIDO1 | T603 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
| Q9BX84 | TRPM6 | T1851 | psp | Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) [Cleaved into: TRPM6 kinase, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain (PubMed:14576148, PubMed:16636202, PubMed:18258429, PubMed:18365021). Crucial for Mg(2+) homeostasis. Has an important role in epithelial Mg(2+) transport and in the active Mg(2+) absorption in the gut and kidney (PubMed:14576148). However, whether TRPM6 forms functional homomeric channels by itself or functions primarily as a subunit of heteromeric TRPM6-TRPM7 channels, is still under debate (PubMed:14576148, PubMed:16636202, PubMed:24385424). {ECO:0000269|PubMed:14576148, ECO:0000269|PubMed:16636202, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:24385424}.; FUNCTION: [TRPM6 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and development. {ECO:0000269|PubMed:28784805}. |
| Q9BY89 | KIAA1671 | T1273 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYX2 | TBC1D2 | T115 | ochoa | TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1) | Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269|PubMed:20116244}. |
| Q9BZF1 | OSBPL8 | T54 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9BZF1 | OSBPL8 | T774 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C040 | TRIM2 | T371 | ochoa | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2) | UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738). {ECO:0000250|UniProtKB:Q9ESN6, ECO:0000269|PubMed:24068738}. |
| Q9C0C2 | TNKS1BP1 | T1282 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9C0K0 | BCL11B | T120 | ochoa | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}. |
| Q9H3P2 | NELFA | T297 | ochoa | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}. |
| Q9H6S3 | EPS8L2 | T303 | ochoa | Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. |
| Q9H8Y8 | GORASP2 | T415 | ochoa | Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) | Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}. |
| Q9HBA0 | TRPV4 | T813 | psp | Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) | Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:22526352, PubMed:23136043, PubMed:29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18695040, PubMed:18826956, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:20037586, PubMed:21964574, PubMed:25256292). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity). {ECO:0000250|UniProtKB:Q9EPK8, ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:18587396, ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956, ECO:0000269|PubMed:19759329, ECO:0000269|PubMed:20037586, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:23136043, ECO:0000269|PubMed:25256292, ECO:0000269|PubMed:26249260, ECO:0000269|PubMed:29899501}.; FUNCTION: [Isoform 1]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. {ECO:0000269|PubMed:29899501}. |
| Q9HBI1 | PARVB | T28 | ochoa | Beta-parvin (Affixin) | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}. |
| Q9NR12 | PDLIM7 | T34 | ochoa | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}. |
| Q9NR19 | ACSS2 | T644 | ochoa | Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17) | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429, PubMed:28552616). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (PubMed:28552616). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (PubMed:28552616). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (PubMed:28552616). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity). {ECO:0000250|UniProtKB:Q9QXG4, ECO:0000269|PubMed:10843999, ECO:0000269|PubMed:28003429, ECO:0000269|PubMed:28552616}. |
| Q9NRA8 | EIF4ENIF1 | T455 | ochoa | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NSC5 | HOMER3 | T36 | psp | Homer protein homolog 3 (Homer-3) | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269|PubMed:18218901}. |
| Q9NTI5 | PDS5B | T1121 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NTI5 | PDS5B | T1301 | ochoa | Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. {ECO:0000269|PubMed:10963680, ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Q9NVD7 | PARVA | T36 | ochoa | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}. |
| Q9NXF1 | TEX10 | T29 | ochoa | Testis-expressed protein 10 | Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). {ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q9NYF8 | BCLAF1 | T840 | ochoa|psp | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9NZM1 | MYOF | T1781 | ochoa | Myoferlin (Fer-1-like protein 3) | Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}. |
| Q9NZN5 | ARHGEF12 | T267 | ochoa | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}. |
| Q9UBU7 | DBF4 | T345 | ochoa | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}. |
| Q9UIS9 | MBD1 | T570 | ochoa | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:12697822, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9207790, ECO:0000269|PubMed:9774669}. |
| Q9UKK9 | NUDT5 | T45 | ochoa | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:17052728, PubMed:19699693, PubMed:21389046). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250|UniProtKB:Q9JKX6, ECO:0000269|PubMed:10567213, ECO:0000269|PubMed:10722730, ECO:0000269|PubMed:17052728, ECO:0000269|PubMed:19699693, ECO:0000269|PubMed:21389046, ECO:0000269|PubMed:27257257}. |
| Q9ULE6 | PALD1 | T89 | ochoa | Paladin | None |
| Q9ULV4 | CORO1C | T415 | ochoa | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
| Q9ULV4 | CORO1C | T430 | ochoa | Coronin-1C (Coronin-3) (hCRNN4) | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460, ECO:0000269|PubMed:34106209}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}. |
| Q9ULW0 | TPX2 | T147 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9ULW0 | TPX2 | T179 | ochoa | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100) | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764, ECO:0000269|PubMed:26165940}. |
| Q9ULX3 | NOB1 | T210 | ochoa | RNA-binding protein NOB1 (EC 3.1.-.-) (Phosphorylation regulatory protein HP-10) (Protein ART-4) | May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). {ECO:0000250|UniProtKB:Q9FLL1, ECO:0000305}. |
| Q9UMD9 | COL17A1 | T320 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UNZ2 | NSFL1C | T263 | ochoa | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}. |
| Q9UPN3 | MACF1 | T4391 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPN3 | MACF1 | T7213 | ochoa|psp | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9Y232 | CDYL | T207 | ochoa | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) | [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:22009739, ECO:0000269|PubMed:28402439, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:29177481}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672). {ECO:0000269|PubMed:19808672}.; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. {ECO:0000269|PubMed:19808672}. |
| Q9Y2W1 | THRAP3 | T874 | ochoa|psp | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q9Y4B5 | MTCL1 | T1438 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4D8 | HECTD4 | T3269 | ochoa | Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}. |
| Q9Y4E8 | USP15 | T149 | psp | Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4) | Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178, ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004, ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298, ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}. |
| Q9Y5B6 | PAXBP1 | T242 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y6X9 | MORC2 | T733 | ochoa|psp | ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1) | Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755, PubMed:32693025). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20110259, PubMed:20225202). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755, ECO:0000269|PubMed:32693025}. |
| P04040 | CAT | T28 | Sugiyama | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
| Q13561 | DCTN2 | T114 | Sugiyama | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
| O95218 | ZRANB2 | T55 | Sugiyama | Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing) | Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection. {ECO:0000269|PubMed:11448987, ECO:0000269|PubMed:21256132}. |
| P06703 | S100A6 | T43 | Sugiyama | Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6) | May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. {ECO:0000269|PubMed:22399290}. |
| P39019 | RPS19 | T55 | Sugiyama | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:16990592, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P40926 | MDH2 | T227 | Sugiyama | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P62081 | RPS7 | T172 | Sugiyama | Small ribosomal subunit protein eS7 (40S ribosomal protein S7) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| P62424 | RPL7A | T84 | Sugiyama | Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (PLA-X polypeptide) (Surfeit locus protein 3) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| Q9P2D1 | CHD7 | T1227 | EPSD|PSP | Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.-) (ATP-dependent helicase CHD7) | ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Probable transcription regulator. May be involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239, ECO:0000269|PubMed:28533432}. |
| O15146 | MUSK | T537 | Sugiyama | Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) | Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:25537362}. |
| P31939 | ATIC | T297 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P10636 | MAPT | T470 | EPSD | Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}. |
| P11142 | HSPA8 | T427 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| Q14697 | GANAB | T229 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| P11142 | HSPA8 | T37 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P34931 | HSPA1L | T39 | Sugiyama | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P54652 | HSPA2 | T38 | Sugiyama | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| Q99536 | VAT1 | T242 | Sugiyama | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2). {ECO:0000250, ECO:0000269|PubMed:12898150, ECO:0000269|PubMed:17105775, ECO:0000269|PubMed:19508442}. |
| P62857 | RPS28 | T28 | Sugiyama | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}. |
| Q02790 | FKBP4 | T278 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}. |
| Q9BX68 | HINT2 | T54 | Sugiyama | Adenosine 5'-monophosphoramidase HINT2 (EC 3.9.1.-) (HINT-3) (HIT-17kDa) (Histidine triad nucleotide-binding protein 2, mitochondrial) (HINT-2) (PKCI-1-related HIT protein) | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). {ECO:0000269|PubMed:16762638, ECO:0000269|PubMed:18653718, ECO:0000269|PubMed:31990367}. |
| P24752 | ACAT1 | T285 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
| P40925 | MDH1 | T226 | Sugiyama | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase) | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269|PubMed:2449162, ECO:0000269|PubMed:3052244, ECO:0000269|PubMed:31538237}. |
| P48643 | CCT5 | T47 | Sugiyama | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q9Y2X3 | NOP58 | T427 | Sugiyama | Nucleolar protein 58 (Nucleolar protein 5) | Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| P33176 | KIF5B | T80 | Sugiyama | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}. |
| P07814 | EPRS1 | T294 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
| P09769 | FGR | T211 | Sugiyama | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. |
| P12931 | SRC | T221 | Sugiyama | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| Q15181 | PPA1 | T100 | Sugiyama | Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) | None |
| P16234 | PDGFRA | T922 | Sugiyama | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}. |
| O60869 | EDF1 | T91 | SIGNOR|iPTMNet|EPSD | Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) | Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}. |
| P08684 | CYP3A4 | T103 | EPSD|PSP | Cytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:19965576, PubMed:20702771, PubMed:21490593, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:14559847, PubMed:15373842, PubMed:15764715, PubMed:21490593, PubMed:21576599, PubMed:2732228). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:12865317, PubMed:14559847). Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:15373842, PubMed:15764715, PubMed:22773874, PubMed:2732228). Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:15373842, PubMed:15764715, PubMed:2732228). Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599). Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160). Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771). Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812). Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686). Hydroxylates antimalarial drug quinine (PubMed:8968357). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850). Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:11159812, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15373842, ECO:0000269|PubMed:15764715, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20702771, ECO:0000269|PubMed:21490593, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:22773874, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:29461981, ECO:0000269|PubMed:8968357, ECO:0000269|PubMed:9435160}. |
| P41091 | EIF2S3 | T66 | EPSD|PSP | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}. |
| P29322 | EPHA8 | T615 | Sugiyama | Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| P07942 | LAMB1 | T1004 | Sugiyama | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269|PubMed:23472759}. |
| P05091 | ALDH2 | T356 | SIGNOR | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. {ECO:0000269|PubMed:33355142}. |
| Q96E11 | MRRF | T230 | Sugiyama | Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial) | Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). {ECO:0000269|PubMed:19716793, ECO:0000269|PubMed:33878294}. |
| P09972 | ALDOC | T123 | Sugiyama | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | None |
| P08708 | RPS17 | T22 | Sugiyama | Small ribosomal subunit protein eS17 (40S ribosomal protein S17) | Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q13043 | STK4 | T271 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| Q9H173 | SIL1 | T127 | Sugiyama | Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP) | Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269|PubMed:12356756}. |
| Q92973 | TNPO1 | T40 | Sugiyama | Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975}. |
| Q14204 | DYNC1H1 | T695 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| P40939 | HADHA | T395 | Sugiyama | Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] | Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:1550553, PubMed:29915090, PubMed:30850536, PubMed:8135828, PubMed:31604922). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536, PubMed:31604922). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed:29915090, PubMed:30850536, PubMed:8135828). Independently of subunit beta, HADHA also exhibits a cardiolipin acyltransferase activity that participates in cardiolipin remodeling; cardiolipin is a major mitochondrial membrane phospholipid (PubMed:23152787, PubMed:31604922). HADHA may act downstream of Tafazzin/TAZ, that remodels monolysocardiolipin (MLCL) to a cardiolipin intermediate, and then HADHA may continue to remodel this species into mature tetralinoleoyl-cardiolipin (PubMed:31604922). Has also been proposed to act directly on MLCL; capable of acylating MLCL using different acyl-CoA substrates, with highest activity for oleoyl-CoA (PubMed:23152787). {ECO:0000269|PubMed:1550553, ECO:0000269|PubMed:23152787, ECO:0000269|PubMed:29915090, ECO:0000269|PubMed:30850536, ECO:0000269|PubMed:31604922, ECO:0000269|PubMed:8135828, ECO:0000303|PubMed:29915090, ECO:0000303|PubMed:30850536}. |
| P62899 | RPL31 | T59 | Sugiyama | Large ribosomal subunit protein eL31 (60S ribosomal protein L31) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P30622 | CLIP1 | T36 | PSP | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. |
| Q6XUX3 | DSTYK | T62 | Sugiyama | Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) | Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}. |
| O43852 | CALU | T177 | Sugiyama | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| P46940 | IQGAP1 | T1451 | Sugiyama | Ras GTPase-activating-like protein IQGAP1 (p195) | Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000250|UniProtKB:Q9JKF1, ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| Q86UE8 | TLK2 | T300 | Sugiyama | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037). {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}. |
| Q9UKI8 | TLK1 | T304 | Sugiyama | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:9427565}. |
| P30084 | ECHS1 | T269 | Sugiyama | Enoyl-CoA hydratase, mitochondrial (mECH) (mECH1) (EC 4.2.1.17) (EC 5.3.3.8) (Enoyl-CoA hydratase 1) (ECHS1) (Short-chain enoyl-CoA hydratase) (SCEH) | Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:26251176). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA) (PubMed:26251176). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (PubMed:26251176). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:25125611, PubMed:26251176). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity). {ECO:0000250|UniProtKB:P14604, ECO:0000269|PubMed:25125611, ECO:0000269|PubMed:26251176}. |
| Q00796 | SORD | T75 | Sugiyama | Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) ((R,R)-butanediol dehydrogenase) (EC 1.1.1.4) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Ribitol dehydrogenase) (RDH) (EC 1.1.1.56) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively (PubMed:3365415). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:25105142, PubMed:29966615). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369). May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor (PubMed:3365415). {ECO:0000269|PubMed:16278369, ECO:0000269|PubMed:3365415, ECO:0000303|PubMed:25105142, ECO:0000303|PubMed:29966615, ECO:0000305|PubMed:12962626}. |
| P17275 | JUNB | T313 | Sugiyama | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P09450}. |
| Q13164 | MAPK7 | T553 | Sugiyama | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}. |
| Q9P2J5 | LARS1 | T728 | Sugiyama | Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) | Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269|PubMed:19426743, ECO:0000269|PubMed:25051973, ECO:0000269|PubMed:32232361}. |
| Q8N9I0 | SYT2 | T199 | SIGNOR | Synaptotagmin-2 (Synaptotagmin II) (SytII) | Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P46097, ECO:0000269|PubMed:23999003}. |
| Q9Y295 | DRG1 | T194 | Sugiyama | Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-) | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:23711155, PubMed:29915238, PubMed:37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). {ECO:0000269|PubMed:19819225, ECO:0000269|PubMed:23711155, ECO:0000269|PubMed:28855639, ECO:0000269|PubMed:29915238, ECO:0000269|PubMed:37179472}. |
| P07686 | HEXB | T474 | Sugiyama | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:8123671, PubMed:8672428, PubMed:9694901). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). {ECO:0000250|UniProtKB:P20060, ECO:0000269|PubMed:11707436, ECO:0000269|PubMed:8123671, ECO:0000269|PubMed:8672428, ECO:0000269|PubMed:9694901}. |
| P51816 | AFF2 | T625 | Sugiyama | AF4/FMR2 family member 2 (Protein FMR-2) (FMR2P) (Protein Ox19) | RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure. {ECO:0000269|PubMed:19136466}. |
| P04040 | CAT | T361 | Sugiyama | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-3371568 | Attenuation phase | 1.291554e-06 | 5.889 |
| R-HSA-3371571 | HSF1-dependent transactivation | 9.908906e-07 | 6.004 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.447045e-06 | 5.463 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.447045e-06 | 5.463 |
| R-HSA-422475 | Axon guidance | 3.671682e-06 | 5.435 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 4.818569e-06 | 5.317 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 8.037074e-06 | 5.095 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 8.037074e-06 | 5.095 |
| R-HSA-156902 | Peptide chain elongation | 1.278449e-05 | 4.893 |
| R-HSA-9675108 | Nervous system development | 1.262880e-05 | 4.899 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 1.646532e-05 | 4.783 |
| R-HSA-9700206 | Signaling by ALK in cancer | 1.646532e-05 | 4.783 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 2.018657e-05 | 4.695 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 2.121050e-05 | 4.673 |
| R-HSA-1500931 | Cell-Cell communication | 2.215441e-05 | 4.655 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.542196e-05 | 4.595 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 5.885089e-05 | 4.230 |
| R-HSA-72649 | Translation initiation complex formation | 8.086387e-05 | 4.092 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 7.939291e-05 | 4.100 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.132901e-04 | 3.946 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 1.004115e-04 | 3.998 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 8.853954e-05 | 4.053 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 9.595688e-05 | 4.018 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.311201e-04 | 3.882 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 1.237160e-04 | 3.908 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.134461e-04 | 3.945 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.134461e-04 | 3.945 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.187087e-04 | 3.926 |
| R-HSA-446728 | Cell junction organization | 1.292222e-04 | 3.889 |
| R-HSA-2262752 | Cellular responses to stress | 1.041345e-04 | 3.982 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.414383e-04 | 3.849 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.414383e-04 | 3.849 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.635109e-04 | 3.786 |
| R-HSA-1640170 | Cell Cycle | 1.756078e-04 | 3.755 |
| R-HSA-72766 | Translation | 1.840426e-04 | 3.735 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.962183e-04 | 3.707 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.188312e-04 | 3.660 |
| R-HSA-2408522 | Selenoamino acid metabolism | 2.332598e-04 | 3.632 |
| R-HSA-192823 | Viral mRNA Translation | 2.514562e-04 | 3.600 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.328670e-04 | 3.478 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.632939e-04 | 3.249 |
| R-HSA-8953897 | Cellular responses to stimuli | 5.941131e-04 | 3.226 |
| R-HSA-9620244 | Long-term potentiation | 6.659719e-04 | 3.177 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.527171e-04 | 3.185 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 7.205734e-04 | 3.142 |
| R-HSA-373760 | L1CAM interactions | 6.901375e-04 | 3.161 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 7.763857e-04 | 3.110 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 7.678742e-04 | 3.115 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 8.794088e-04 | 3.056 |
| R-HSA-1227986 | Signaling by ERBB2 | 8.470790e-04 | 3.072 |
| R-HSA-3371556 | Cellular response to heat stress | 9.155798e-04 | 3.038 |
| R-HSA-8848021 | Signaling by PTK6 | 1.084485e-03 | 2.965 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.084485e-03 | 2.965 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 1.268371e-03 | 2.897 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.344238e-03 | 2.872 |
| R-HSA-437239 | Recycling pathway of L1 | 1.473848e-03 | 2.832 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.428941e-03 | 2.845 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.515908e-03 | 2.819 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.612765e-03 | 2.792 |
| R-HSA-168255 | Influenza Infection | 1.624311e-03 | 2.789 |
| R-HSA-196025 | Formation of annular gap junctions | 1.923179e-03 | 2.716 |
| R-HSA-390696 | Adrenoceptors | 1.923179e-03 | 2.716 |
| R-HSA-2682334 | EPH-Ephrin signaling | 2.057993e-03 | 2.687 |
| R-HSA-9711097 | Cellular response to starvation | 1.980752e-03 | 2.703 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.259305e-03 | 2.646 |
| R-HSA-190873 | Gap junction degradation | 2.457038e-03 | 2.610 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.429492e-03 | 2.614 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.666009e-03 | 2.574 |
| R-HSA-3371511 | HSF1 activation | 2.767770e-03 | 2.558 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 3.074202e-03 | 2.512 |
| R-HSA-5683057 | MAPK family signaling cascades | 3.411263e-03 | 2.467 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 3.696675e-03 | 2.432 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.706435e-03 | 2.431 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.808854e-03 | 2.419 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 4.025253e-03 | 2.395 |
| R-HSA-72312 | rRNA processing | 4.176927e-03 | 2.379 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 4.534147e-03 | 2.344 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.787056e-03 | 2.320 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 4.796656e-03 | 2.319 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.203994e-03 | 2.284 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 5.338968e-03 | 2.273 |
| R-HSA-3295583 | TRP channels | 5.674480e-03 | 2.246 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 5.830811e-03 | 2.234 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.214563e-03 | 2.207 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 7.036707e-03 | 2.153 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 7.719955e-03 | 2.112 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 7.679985e-03 | 2.115 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 7.719955e-03 | 2.112 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 7.130086e-03 | 2.147 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 7.130086e-03 | 2.147 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 7.130086e-03 | 2.147 |
| R-HSA-6802949 | Signaling by RAS mutants | 7.130086e-03 | 2.147 |
| R-HSA-191650 | Regulation of gap junction activity | 7.865968e-03 | 2.104 |
| R-HSA-9705677 | SARS-CoV-2 targets PDZ proteins in cell-cell junction | 7.865968e-03 | 2.104 |
| R-HSA-68962 | Activation of the pre-replicative complex | 8.496427e-03 | 2.071 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 8.496427e-03 | 2.071 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 8.496427e-03 | 2.071 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 8.720288e-03 | 2.059 |
| R-HSA-157858 | Gap junction trafficking and regulation | 8.867000e-03 | 2.052 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 9.462961e-03 | 2.024 |
| R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 1.055421e-02 | 1.977 |
| R-HSA-6794361 | Neurexins and neuroligins | 1.087617e-02 | 1.964 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.112682e-02 | 1.954 |
| R-HSA-1538133 | G0 and Early G1 | 1.019872e-02 | 1.991 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.059947e-02 | 1.975 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.059947e-02 | 1.975 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.132511e-02 | 1.946 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 1.140547e-02 | 1.943 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.160960e-02 | 1.935 |
| R-HSA-390522 | Striated Muscle Contraction | 1.210765e-02 | 1.917 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 1.290707e-02 | 1.889 |
| R-HSA-3928664 | Ephrin signaling | 1.451628e-02 | 1.838 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 1.358942e-02 | 1.867 |
| R-HSA-397014 | Muscle contraction | 1.434829e-02 | 1.843 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 1.401008e-02 | 1.854 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 1.439545e-02 | 1.842 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.401008e-02 | 1.854 |
| R-HSA-8853659 | RET signaling | 1.537626e-02 | 1.813 |
| R-HSA-69275 | G2/M Transition | 1.600843e-02 | 1.796 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.695543e-02 | 1.771 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 1.657748e-02 | 1.780 |
| R-HSA-445144 | Signal transduction by L1 | 1.806096e-02 | 1.743 |
| R-HSA-68886 | M Phase | 1.724695e-02 | 1.763 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.750505e-02 | 1.757 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.699491e-02 | 1.770 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 1.695543e-02 | 1.771 |
| R-HSA-379724 | tRNA Aminoacylation | 1.770033e-02 | 1.752 |
| R-HSA-421270 | Cell-cell junction organization | 1.753143e-02 | 1.756 |
| R-HSA-418990 | Adherens junctions interactions | 1.697577e-02 | 1.770 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.613407e-02 | 1.792 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.997976e-02 | 1.699 |
| R-HSA-438064 | Post NMDA receptor activation events | 2.002656e-02 | 1.698 |
| R-HSA-9674415 | Drug resistance of PDGFR mutants | 2.162276e-02 | 1.665 |
| R-HSA-9674428 | PDGFR mutants bind TKIs | 2.162276e-02 | 1.665 |
| R-HSA-9674404 | Sorafenib-resistant PDGFR mutants | 2.162276e-02 | 1.665 |
| R-HSA-9674403 | Regorafenib-resistant PDGFR mutants | 2.162276e-02 | 1.665 |
| R-HSA-9674396 | Imatinib-resistant PDGFR mutants | 2.162276e-02 | 1.665 |
| R-HSA-9661070 | Defective translocation of RB1 mutants to the nucleus | 2.162276e-02 | 1.665 |
| R-HSA-9674401 | Sunitinib-resistant PDGFR mutants | 2.162276e-02 | 1.665 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 2.063658e-02 | 1.685 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.085452e-02 | 1.681 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.085452e-02 | 1.681 |
| R-HSA-373755 | Semaphorin interactions | 2.085452e-02 | 1.681 |
| R-HSA-8953854 | Metabolism of RNA | 2.323647e-02 | 1.634 |
| R-HSA-9022707 | MECP2 regulates transcription factors | 2.063658e-02 | 1.685 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 2.213173e-02 | 1.655 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 2.139463e-02 | 1.670 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.341358e-02 | 1.631 |
| R-HSA-5674135 | MAP2K and MAPK activation | 2.345512e-02 | 1.630 |
| R-HSA-446107 | Type I hemidesmosome assembly | 2.461777e-02 | 1.609 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 2.646726e-02 | 1.577 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.680764e-02 | 1.572 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.688597e-02 | 1.570 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 2.810648e-02 | 1.551 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 2.830006e-02 | 1.548 |
| R-HSA-375280 | Amine ligand-binding receptors | 2.830006e-02 | 1.548 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.830006e-02 | 1.548 |
| R-HSA-429947 | Deadenylation of mRNA | 2.884347e-02 | 1.540 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 3.342225e-02 | 1.476 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.662532e-02 | 1.436 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.662532e-02 | 1.436 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.662532e-02 | 1.436 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 3.392771e-02 | 1.469 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.392314e-02 | 1.470 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.243658e-02 | 1.489 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.243658e-02 | 1.489 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.260109e-02 | 1.487 |
| R-HSA-69206 | G1/S Transition | 3.595565e-02 | 1.444 |
| R-HSA-68882 | Mitotic Anaphase | 3.680224e-02 | 1.434 |
| R-HSA-380287 | Centrosome maturation | 3.703594e-02 | 1.431 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 3.703594e-02 | 1.431 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.724887e-02 | 1.429 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.768832e-02 | 1.424 |
| R-HSA-69481 | G2/M Checkpoints | 3.831439e-02 | 1.417 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 3.853660e-02 | 1.414 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.947683e-02 | 1.404 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.203923e-02 | 1.376 |
| R-HSA-3656248 | Defective HEXB causes GM2G2 (Hyaluronan metabolism) | 4.277928e-02 | 1.369 |
| R-HSA-5545483 | Defective Mismatch Repair Associated With MLH1 | 4.277928e-02 | 1.369 |
| R-HSA-5632987 | Defective Mismatch Repair Associated With PMS2 | 4.277928e-02 | 1.369 |
| R-HSA-9692912 | SARS-CoV-1 targets PDZ proteins in cell-cell junction | 4.277928e-02 | 1.369 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 4.325770e-02 | 1.364 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 4.325770e-02 | 1.364 |
| R-HSA-9659379 | Sensory processing of sound | 4.376197e-02 | 1.359 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 4.852932e-02 | 1.314 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 5.402031e-02 | 1.267 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.849556e-02 | 1.314 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.173324e-02 | 1.286 |
| R-HSA-68877 | Mitotic Prometaphase | 4.566160e-02 | 1.340 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 5.313606e-02 | 1.275 |
| R-HSA-202403 | TCR signaling | 5.341139e-02 | 1.272 |
| R-HSA-1266738 | Developmental Biology | 4.734768e-02 | 1.325 |
| R-HSA-9833482 | PKR-mediated signaling | 4.555054e-02 | 1.342 |
| R-HSA-9711123 | Cellular response to chemical stress | 5.439790e-02 | 1.264 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 5.514046e-02 | 1.259 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 5.514046e-02 | 1.259 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 5.971877e-02 | 1.224 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 5.971877e-02 | 1.224 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 5.971877e-02 | 1.224 |
| R-HSA-9856872 | Malate-aspartate shuttle | 5.971877e-02 | 1.224 |
| R-HSA-391160 | Signal regulatory protein family interactions | 5.971877e-02 | 1.224 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 6.088722e-02 | 1.215 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 6.200687e-02 | 1.208 |
| R-HSA-5689880 | Ub-specific processing proteases | 6.258665e-02 | 1.204 |
| R-HSA-6798695 | Neutrophil degranulation | 6.319360e-02 | 1.199 |
| R-HSA-9915355 | Beta-ketothiolase deficiency | 6.347958e-02 | 1.197 |
| R-HSA-9916720 | Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 | 6.347958e-02 | 1.197 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 6.358998e-02 | 1.197 |
| R-HSA-9663891 | Selective autophagy | 6.358998e-02 | 1.197 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.476945e-02 | 1.189 |
| R-HSA-8876725 | Protein methylation | 6.561323e-02 | 1.183 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 6.561323e-02 | 1.183 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 6.607801e-02 | 1.180 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.807301e-02 | 1.167 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 6.934902e-02 | 1.159 |
| R-HSA-1592230 | Mitochondrial biogenesis | 6.999318e-02 | 1.155 |
| R-HSA-198765 | Signalling to ERK5 | 8.373347e-02 | 1.077 |
| R-HSA-1296067 | Potassium transport channels | 8.373347e-02 | 1.077 |
| R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions | 8.373347e-02 | 1.077 |
| R-HSA-69306 | DNA Replication | 8.410118e-02 | 1.075 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 7.794618e-02 | 1.108 |
| R-HSA-69242 | S Phase | 7.462730e-02 | 1.127 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.252527e-02 | 1.083 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 7.316092e-02 | 1.136 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 7.169260e-02 | 1.145 |
| R-HSA-2028269 | Signaling by Hippo | 8.436365e-02 | 1.074 |
| R-HSA-5688426 | Deubiquitination | 8.292229e-02 | 1.081 |
| R-HSA-9837999 | Mitochondrial protein degradation | 8.002614e-02 | 1.097 |
| R-HSA-112316 | Neuronal System | 7.381701e-02 | 1.132 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.749794e-02 | 1.058 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 7.794618e-02 | 1.108 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 7.778719e-02 | 1.109 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 7.200007e-02 | 1.143 |
| R-HSA-8941237 | Invadopodia formation | 1.035506e-01 | 0.985 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 1.229402e-01 | 0.910 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 1.229402e-01 | 0.910 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 1.229402e-01 | 0.910 |
| R-HSA-2978092 | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate | 1.229402e-01 | 0.910 |
| R-HSA-111463 | SMAC (DIABLO) binds to IAPs | 1.419117e-01 | 0.848 |
| R-HSA-111464 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes | 1.419117e-01 | 0.848 |
| R-HSA-111469 | SMAC, XIAP-regulated apoptotic response | 1.604739e-01 | 0.795 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 1.604739e-01 | 0.795 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 1.604739e-01 | 0.795 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.604739e-01 | 0.795 |
| R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage | 1.604739e-01 | 0.795 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 1.604739e-01 | 0.795 |
| R-HSA-9842640 | Signaling by LTK in cancer | 1.786357e-01 | 0.748 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 1.786357e-01 | 0.748 |
| R-HSA-8849473 | PTK6 Expression | 1.964057e-01 | 0.707 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 1.964057e-01 | 0.707 |
| R-HSA-72731 | Recycling of eIF2:GDP | 1.964057e-01 | 0.707 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 1.964057e-01 | 0.707 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 2.137923e-01 | 0.670 |
| R-HSA-190370 | FGFR1b ligand binding and activation | 2.137923e-01 | 0.670 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 9.765072e-02 | 1.010 |
| R-HSA-9613354 | Lipophagy | 2.308038e-01 | 0.637 |
| R-HSA-5218900 | CASP8 activity is inhibited | 2.308038e-01 | 0.637 |
| R-HSA-9700645 | ALK mutants bind TKIs | 2.308038e-01 | 0.637 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.045014e-01 | 0.981 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 1.045014e-01 | 0.981 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.045014e-01 | 0.981 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 1.045014e-01 | 0.981 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 1.045014e-01 | 0.981 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.114783e-01 | 0.953 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 2.637334e-01 | 0.579 |
| R-HSA-190377 | FGFR2b ligand binding and activation | 2.637334e-01 | 0.579 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.404788e-01 | 0.852 |
| R-HSA-1234158 | Regulation of gene expression by Hypoxia-inducible Factor | 2.796673e-01 | 0.553 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 2.796673e-01 | 0.553 |
| R-HSA-202670 | ERKs are inactivated | 2.796673e-01 | 0.553 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 1.479630e-01 | 0.830 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 3.105107e-01 | 0.508 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 3.105107e-01 | 0.508 |
| R-HSA-9615710 | Late endosomal microautophagy | 1.786210e-01 | 0.748 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 3.254349e-01 | 0.488 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 3.254349e-01 | 0.488 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 3.400370e-01 | 0.468 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 3.400370e-01 | 0.468 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 3.400370e-01 | 0.468 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 3.400370e-01 | 0.468 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 3.400370e-01 | 0.468 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.180971e-01 | 0.661 |
| R-HSA-1221632 | Meiotic synapsis | 1.503538e-01 | 0.823 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 1.503538e-01 | 0.823 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.929706e-01 | 0.715 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.381387e-01 | 0.623 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 3.303875e-01 | 0.481 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 2.172231e-01 | 0.663 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 3.383144e-01 | 0.471 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.381879e-01 | 0.471 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.381879e-01 | 0.471 |
| R-HSA-186763 | Downstream signal transduction | 1.942927e-01 | 0.712 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 2.260900e-01 | 0.646 |
| R-HSA-2467813 | Separation of Sister Chromatids | 1.072481e-01 | 0.970 |
| R-HSA-9646399 | Aggrephagy | 2.743292e-01 | 0.562 |
| R-HSA-177929 | Signaling by EGFR | 1.659694e-01 | 0.780 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 2.823771e-01 | 0.549 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.500400e-01 | 0.456 |
| R-HSA-180292 | GAB1 signalosome | 9.093503e-02 | 1.041 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 1.964057e-01 | 0.707 |
| R-HSA-156711 | Polo-like kinase mediated events | 9.093503e-02 | 1.041 |
| R-HSA-3000157 | Laminin interactions | 1.479630e-01 | 0.830 |
| R-HSA-8874081 | MET activates PTK2 signaling | 1.555261e-01 | 0.808 |
| R-HSA-110312 | Translesion synthesis by REV1 | 3.400370e-01 | 0.468 |
| R-HSA-354192 | Integrin signaling | 2.101299e-01 | 0.678 |
| R-HSA-110320 | Translesion Synthesis by POLH | 9.765072e-02 | 1.010 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 2.952572e-01 | 0.530 |
| R-HSA-69091 | Polymerase switching | 2.952572e-01 | 0.530 |
| R-HSA-69109 | Leading Strand Synthesis | 2.952572e-01 | 0.530 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 2.952572e-01 | 0.530 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.421336e-01 | 0.616 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.260900e-01 | 0.646 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 2.582244e-01 | 0.588 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.224344e-01 | 0.492 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.404788e-01 | 0.852 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 2.613649e-01 | 0.583 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 2.180971e-01 | 0.661 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 2.137923e-01 | 0.670 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 2.137923e-01 | 0.670 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 2.796673e-01 | 0.553 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 2.952572e-01 | 0.530 |
| R-HSA-418885 | DCC mediated attractive signaling | 3.400370e-01 | 0.468 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 2.101299e-01 | 0.678 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 9.093503e-02 | 1.041 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 2.101299e-01 | 0.678 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.758400e-01 | 0.755 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 3.303875e-01 | 0.481 |
| R-HSA-9692913 | SARS-CoV-1-mediated effects on programmed cell death | 1.229402e-01 | 0.910 |
| R-HSA-5250958 | Toxicity of botulinum toxin type B (botB) | 2.137923e-01 | 0.670 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 2.976906e-01 | 0.526 |
| R-HSA-75893 | TNF signaling | 1.659694e-01 | 0.780 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.266635e-01 | 0.645 |
| R-HSA-198753 | ERK/MAPK targets | 1.114783e-01 | 0.953 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 8.930500e-02 | 1.049 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 1.503538e-01 | 0.823 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.260900e-01 | 0.646 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 1.903859e-01 | 0.720 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 3.224344e-01 | 0.492 |
| R-HSA-5693538 | Homology Directed Repair | 3.270107e-01 | 0.485 |
| R-HSA-389542 | NADPH regeneration | 1.786357e-01 | 0.748 |
| R-HSA-114516 | Disinhibition of SNARE formation | 1.964057e-01 | 0.707 |
| R-HSA-3371378 | Regulation by c-FLIP | 2.137923e-01 | 0.670 |
| R-HSA-5652227 | Fructose biosynthesis | 2.137923e-01 | 0.670 |
| R-HSA-176974 | Unwinding of DNA | 2.308038e-01 | 0.637 |
| R-HSA-9693928 | Defective RIPK1-mediated regulated necrosis | 2.474482e-01 | 0.607 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 2.474482e-01 | 0.607 |
| R-HSA-390666 | Serotonin receptors | 2.474482e-01 | 0.607 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 2.474482e-01 | 0.607 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 2.474482e-01 | 0.607 |
| R-HSA-380612 | Metabolism of serotonin | 2.474482e-01 | 0.607 |
| R-HSA-6803544 | Ion influx/efflux at host-pathogen interface | 2.474482e-01 | 0.607 |
| R-HSA-177135 | Conjugation of benzoate with glycine | 2.637334e-01 | 0.579 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 2.637334e-01 | 0.579 |
| R-HSA-75896 | Plasmalogen biosynthesis | 2.796673e-01 | 0.553 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.952572e-01 | 0.530 |
| R-HSA-177128 | Conjugation of salicylate with glycine | 2.952572e-01 | 0.530 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 3.105107e-01 | 0.508 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 3.400370e-01 | 0.468 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 3.400370e-01 | 0.468 |
| R-HSA-68949 | Orc1 removal from chromatin | 1.452588e-01 | 0.838 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.260900e-01 | 0.646 |
| R-HSA-1500620 | Meiosis | 1.483491e-01 | 0.829 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.099569e-01 | 0.959 |
| R-HSA-9686347 | Microbial modulation of RIPK1-mediated regulated necrosis | 1.964057e-01 | 0.707 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 9.765072e-02 | 1.010 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.743292e-01 | 0.562 |
| R-HSA-69239 | Synthesis of DNA | 2.639478e-01 | 0.578 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 1.045014e-01 | 0.981 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.288511e-01 | 0.890 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 2.308038e-01 | 0.637 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 2.637334e-01 | 0.579 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 3.254349e-01 | 0.488 |
| R-HSA-171007 | p38MAPK events | 3.400370e-01 | 0.468 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.402224e-01 | 0.853 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.582244e-01 | 0.588 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.907683e-01 | 0.536 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.952572e-01 | 0.530 |
| R-HSA-1433559 | Regulation of KIT signaling | 3.254349e-01 | 0.488 |
| R-HSA-5689603 | UCH proteinases | 2.789695e-01 | 0.554 |
| R-HSA-9734767 | Developmental Cell Lineages | 9.545760e-02 | 1.020 |
| R-HSA-9612973 | Autophagy | 1.839983e-01 | 0.735 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.198422e-01 | 0.495 |
| R-HSA-194138 | Signaling by VEGF | 8.923001e-02 | 1.049 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 1.035506e-01 | 0.985 |
| R-HSA-71737 | Pyrophosphate hydrolysis | 1.419117e-01 | 0.848 |
| R-HSA-69416 | Dimerization of procaspase-8 | 2.137923e-01 | 0.670 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 2.474482e-01 | 0.607 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 2.474482e-01 | 0.607 |
| R-HSA-210747 | Regulation of gene expression in early pancreatic precursor cells | 2.637334e-01 | 0.579 |
| R-HSA-77108 | Utilization of Ketone Bodies | 2.637334e-01 | 0.579 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 2.796673e-01 | 0.553 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 3.105107e-01 | 0.508 |
| R-HSA-69190 | DNA strand elongation | 2.021934e-01 | 0.694 |
| R-HSA-8875878 | MET promotes cell motility | 2.582244e-01 | 0.588 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 2.081615e-01 | 0.682 |
| R-HSA-9033241 | Peroxisomal protein import | 1.820364e-01 | 0.740 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 3.462126e-01 | 0.461 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.479630e-01 | 0.830 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.479630e-01 | 0.830 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 2.497107e-01 | 0.603 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 2.497107e-01 | 0.603 |
| R-HSA-9733709 | Cardiogenesis | 2.101299e-01 | 0.678 |
| R-HSA-9664407 | Parasite infection | 2.612409e-01 | 0.583 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.612409e-01 | 0.583 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.612409e-01 | 0.583 |
| R-HSA-373752 | Netrin-1 signaling | 3.144580e-01 | 0.502 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.907683e-01 | 0.536 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 1.708616e-01 | 0.767 |
| R-HSA-1632852 | Macroautophagy | 1.353469e-01 | 0.869 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 2.260900e-01 | 0.646 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 2.289889e-01 | 0.640 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 2.555284e-01 | 0.593 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 2.101299e-01 | 0.678 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.823771e-01 | 0.549 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.439135e-01 | 0.613 |
| R-HSA-3214847 | HATs acetylate histones | 2.217938e-01 | 0.654 |
| R-HSA-199991 | Membrane Trafficking | 1.502996e-01 | 0.823 |
| R-HSA-8948747 | Regulation of PTEN localization | 1.964057e-01 | 0.707 |
| R-HSA-418886 | Netrin mediated repulsion signals | 1.964057e-01 | 0.707 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 2.137923e-01 | 0.670 |
| R-HSA-9683686 | Maturation of spike protein | 2.474482e-01 | 0.607 |
| R-HSA-71384 | Ethanol oxidation | 1.257761e-01 | 0.900 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 2.796673e-01 | 0.553 |
| R-HSA-428540 | Activation of RAC1 | 2.796673e-01 | 0.553 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.952572e-01 | 0.530 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.786210e-01 | 0.748 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 3.400370e-01 | 0.468 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 2.662770e-01 | 0.575 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 2.040638e-01 | 0.690 |
| R-HSA-8939211 | ESR-mediated signaling | 3.320758e-01 | 0.479 |
| R-HSA-9609507 | Protein localization | 3.198422e-01 | 0.495 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.515791e-01 | 0.454 |
| R-HSA-162582 | Signal Transduction | 9.174533e-02 | 1.037 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.491633e-01 | 0.604 |
| R-HSA-69236 | G1 Phase | 3.144580e-01 | 0.502 |
| R-HSA-69231 | Cyclin D associated events in G1 | 3.144580e-01 | 0.502 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 2.474482e-01 | 0.607 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.479630e-01 | 0.830 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 2.449733e-01 | 0.611 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.783295e-01 | 0.555 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 2.308038e-01 | 0.637 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 2.904174e-01 | 0.537 |
| R-HSA-5617833 | Cilium Assembly | 1.766065e-01 | 0.753 |
| R-HSA-8941326 | RUNX2 regulates bone development | 2.421336e-01 | 0.616 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.783295e-01 | 0.555 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.544404e-01 | 0.594 |
| R-HSA-9675135 | Diseases of DNA repair | 1.159957e-01 | 0.936 |
| R-HSA-112315 | Transmission across Chemical Synapses | 2.214702e-01 | 0.655 |
| R-HSA-447041 | CHL1 interactions | 1.964057e-01 | 0.707 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.964057e-01 | 0.707 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 2.308038e-01 | 0.637 |
| R-HSA-9629569 | Protein hydroxylation | 1.045014e-01 | 0.981 |
| R-HSA-8964038 | LDL clearance | 1.257761e-01 | 0.900 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 2.637334e-01 | 0.579 |
| R-HSA-190828 | Gap junction trafficking | 1.067905e-01 | 0.971 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 1.864334e-01 | 0.729 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 3.254349e-01 | 0.488 |
| R-HSA-173599 | Formation of the active cofactor, UDP-glucuronate | 3.254349e-01 | 0.488 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.035426e-01 | 0.985 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 2.662770e-01 | 0.575 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 2.743292e-01 | 0.562 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.473175e-01 | 0.607 |
| R-HSA-450294 | MAP kinase activation | 1.929706e-01 | 0.715 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 1.555261e-01 | 0.808 |
| R-HSA-5578775 | Ion homeostasis | 1.659694e-01 | 0.780 |
| R-HSA-202433 | Generation of second messenger molecules | 2.743292e-01 | 0.562 |
| R-HSA-936837 | Ion transport by P-type ATPases | 2.096651e-01 | 0.678 |
| R-HSA-448424 | Interleukin-17 signaling | 2.439135e-01 | 0.613 |
| R-HSA-392499 | Metabolism of proteins | 1.364793e-01 | 0.865 |
| R-HSA-9840373 | Cellular response to mitochondrial stress | 2.308038e-01 | 0.637 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.045014e-01 | 0.981 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 1.045014e-01 | 0.981 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 2.474482e-01 | 0.607 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 3.105107e-01 | 0.508 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 3.254349e-01 | 0.488 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 2.662770e-01 | 0.575 |
| R-HSA-1280218 | Adaptive Immune System | 3.119186e-01 | 0.506 |
| R-HSA-983712 | Ion channel transport | 8.913654e-02 | 1.050 |
| R-HSA-2672351 | Stimuli-sensing channels | 1.251267e-01 | 0.903 |
| R-HSA-9907900 | Proteasome assembly | 3.144580e-01 | 0.502 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 1.604739e-01 | 0.795 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 2.137923e-01 | 0.670 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 2.474482e-01 | 0.607 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 2.474482e-01 | 0.607 |
| R-HSA-210990 | PECAM1 interactions | 2.637334e-01 | 0.579 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 3.254349e-01 | 0.488 |
| R-HSA-1474244 | Extracellular matrix organization | 1.506627e-01 | 0.822 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.074340e-01 | 0.512 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.056294e-01 | 0.687 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 1.419117e-01 | 0.848 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 2.555284e-01 | 0.593 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.730871e-01 | 0.564 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 3.441162e-01 | 0.463 |
| R-HSA-449836 | Other interleukin signaling | 9.765072e-02 | 1.010 |
| R-HSA-6806834 | Signaling by MET | 1.288511e-01 | 0.890 |
| R-HSA-9909396 | Circadian clock | 2.250416e-01 | 0.648 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.441162e-01 | 0.463 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 2.582244e-01 | 0.588 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.114783e-01 | 0.953 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 2.637334e-01 | 0.579 |
| R-HSA-166520 | Signaling by NTRKs | 1.588542e-01 | 0.799 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 1.257761e-01 | 0.900 |
| R-HSA-389356 | Co-stimulation by CD28 | 3.462126e-01 | 0.461 |
| R-HSA-9824446 | Viral Infection Pathways | 1.792087e-01 | 0.747 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 2.137923e-01 | 0.670 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 2.137923e-01 | 0.670 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 2.308038e-01 | 0.637 |
| R-HSA-111458 | Formation of apoptosome | 2.474482e-01 | 0.607 |
| R-HSA-9842663 | Signaling by LTK | 2.952572e-01 | 0.530 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.341037e-01 | 0.631 |
| R-HSA-9013694 | Signaling by NOTCH4 | 2.672184e-01 | 0.573 |
| R-HSA-168256 | Immune System | 1.182991e-01 | 0.927 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 3.400370e-01 | 0.468 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.101299e-01 | 0.678 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 3.254349e-01 | 0.488 |
| R-HSA-5673000 | RAF activation | 2.260900e-01 | 0.646 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 2.501752e-01 | 0.602 |
| R-HSA-9664873 | Pexophagy | 2.474482e-01 | 0.607 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.113506e-01 | 0.507 |
| R-HSA-913531 | Interferon Signaling | 2.724458e-01 | 0.565 |
| R-HSA-9008059 | Interleukin-37 signaling | 1.864334e-01 | 0.729 |
| R-HSA-69205 | G1/S-Specific Transcription | 2.421336e-01 | 0.616 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 3.025578e-01 | 0.519 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.711192e-01 | 0.567 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 3.159194e-01 | 0.500 |
| R-HSA-9679506 | SARS-CoV Infections | 2.813020e-01 | 0.551 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 2.662770e-01 | 0.575 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 2.904174e-01 | 0.537 |
| R-HSA-70263 | Gluconeogenesis | 3.462126e-01 | 0.461 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 2.260900e-01 | 0.646 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.547082e-01 | 0.594 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 1.212417e-01 | 0.916 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.021934e-01 | 0.694 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 1.631611e-01 | 0.787 |
| R-HSA-9682706 | Replication of the SARS-CoV-1 genome | 3.105107e-01 | 0.508 |
| R-HSA-449147 | Signaling by Interleukins | 1.772005e-01 | 0.752 |
| R-HSA-9679514 | SARS-CoV-1 Genome Replication and Transcription | 3.254349e-01 | 0.488 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.140893e-01 | 0.943 |
| R-HSA-75153 | Apoptotic execution phase | 3.303875e-01 | 0.481 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 2.497107e-01 | 0.603 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 3.253899e-01 | 0.488 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.605615e-01 | 0.794 |
| R-HSA-73893 | DNA Damage Bypass | 3.540797e-01 | 0.451 |
| R-HSA-9766229 | Degradation of CDH1 | 3.540797e-01 | 0.451 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.540797e-01 | 0.451 |
| R-HSA-5656121 | Translesion synthesis by POLI | 3.543239e-01 | 0.451 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 3.543239e-01 | 0.451 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 3.543239e-01 | 0.451 |
| R-HSA-168275 | Entry of Influenza Virion into Host Cell via Endocytosis | 3.543239e-01 | 0.451 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 3.543239e-01 | 0.451 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 3.543239e-01 | 0.451 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 3.543239e-01 | 0.451 |
| R-HSA-9754706 | Atorvastatin ADME | 3.543239e-01 | 0.451 |
| R-HSA-9706369 | Negative regulation of FLT3 | 3.543239e-01 | 0.451 |
| R-HSA-109581 | Apoptosis | 3.583282e-01 | 0.446 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.619133e-01 | 0.441 |
| R-HSA-109704 | PI3K Cascade | 3.619133e-01 | 0.441 |
| R-HSA-202424 | Downstream TCR signaling | 3.677721e-01 | 0.434 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 3.683024e-01 | 0.434 |
| R-HSA-5655862 | Translesion synthesis by POLK | 3.683024e-01 | 0.434 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 3.683024e-01 | 0.434 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 3.683024e-01 | 0.434 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 3.683024e-01 | 0.434 |
| R-HSA-5661270 | Formation of xylulose-5-phosphate | 3.683024e-01 | 0.434 |
| R-HSA-9027307 | Biosynthesis of maresin-like SPMs | 3.683024e-01 | 0.434 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.697112e-01 | 0.432 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 3.697112e-01 | 0.432 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 3.736655e-01 | 0.428 |
| R-HSA-4839726 | Chromatin organization | 3.742872e-01 | 0.427 |
| R-HSA-114608 | Platelet degranulation | 3.761605e-01 | 0.425 |
| R-HSA-72187 | mRNA 3'-end processing | 3.774712e-01 | 0.423 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.774712e-01 | 0.423 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 3.774712e-01 | 0.423 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 3.774712e-01 | 0.423 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 3.819791e-01 | 0.418 |
| R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 | 3.819791e-01 | 0.418 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.819791e-01 | 0.418 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.819791e-01 | 0.418 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 3.819791e-01 | 0.418 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 3.819791e-01 | 0.418 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 3.819791e-01 | 0.418 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 3.819791e-01 | 0.418 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 3.819791e-01 | 0.418 |
| R-HSA-9694686 | Replication of the SARS-CoV-2 genome | 3.819791e-01 | 0.418 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.851913e-01 | 0.414 |
| R-HSA-391251 | Protein folding | 3.854192e-01 | 0.414 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.928697e-01 | 0.406 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 3.953605e-01 | 0.403 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 3.953605e-01 | 0.403 |
| R-HSA-2033519 | Activated point mutants of FGFR2 | 3.953605e-01 | 0.403 |
| R-HSA-5358508 | Mismatch Repair | 3.953605e-01 | 0.403 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 3.953605e-01 | 0.403 |
| R-HSA-111471 | Apoptotic factor-mediated response | 3.953605e-01 | 0.403 |
| R-HSA-432142 | Platelet sensitization by LDL | 3.953605e-01 | 0.403 |
| R-HSA-190242 | FGFR1 ligand binding and activation | 3.953605e-01 | 0.403 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 3.953605e-01 | 0.403 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 3.953605e-01 | 0.403 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.953605e-01 | 0.403 |
| R-HSA-1474165 | Reproduction | 3.957707e-01 | 0.403 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 4.005046e-01 | 0.397 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 4.005046e-01 | 0.397 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.012524e-01 | 0.397 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.055416e-01 | 0.392 |
| R-HSA-5654736 | Signaling by FGFR1 | 4.080942e-01 | 0.389 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.080942e-01 | 0.389 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.080942e-01 | 0.389 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 4.084530e-01 | 0.389 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 4.084530e-01 | 0.389 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 4.084530e-01 | 0.389 |
| R-HSA-159424 | Conjugation of carboxylic acids | 4.084530e-01 | 0.389 |
| R-HSA-156587 | Amino Acid conjugation | 4.084530e-01 | 0.389 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 4.084530e-01 | 0.389 |
| R-HSA-9694682 | SARS-CoV-2 Genome Replication and Transcription | 4.084530e-01 | 0.389 |
| R-HSA-168249 | Innate Immune System | 4.144743e-01 | 0.383 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.145587e-01 | 0.382 |
| R-HSA-112399 | IRS-mediated signalling | 4.156369e-01 | 0.381 |
| R-HSA-5663205 | Infectious disease | 4.175879e-01 | 0.379 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 4.183596e-01 | 0.378 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.203364e-01 | 0.376 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 4.212627e-01 | 0.375 |
| R-HSA-5654221 | Phospholipase C-mediated cascade; FGFR2 | 4.212627e-01 | 0.375 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 4.212627e-01 | 0.375 |
| R-HSA-2022857 | Keratan sulfate degradation | 4.212627e-01 | 0.375 |
| R-HSA-8848584 | Wax and plasmalogen biosynthesis | 4.212627e-01 | 0.375 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 4.212627e-01 | 0.375 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 4.212627e-01 | 0.375 |
| R-HSA-373753 | Nephrin family interactions | 4.212627e-01 | 0.375 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 4.231312e-01 | 0.374 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 4.231312e-01 | 0.374 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 4.260950e-01 | 0.370 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 4.260950e-01 | 0.370 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 4.260950e-01 | 0.370 |
| R-HSA-74160 | Gene expression (Transcription) | 4.279048e-01 | 0.369 |
| R-HSA-180786 | Extension of Telomeres | 4.305756e-01 | 0.366 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 4.305756e-01 | 0.366 |
| R-HSA-1643685 | Disease | 4.324837e-01 | 0.364 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 4.337959e-01 | 0.363 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 4.337959e-01 | 0.363 |
| R-HSA-190241 | FGFR2 ligand binding and activation | 4.337959e-01 | 0.363 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 4.337959e-01 | 0.363 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 4.337959e-01 | 0.363 |
| R-HSA-69186 | Lagging Strand Synthesis | 4.337959e-01 | 0.363 |
| R-HSA-167044 | Signalling to RAS | 4.337959e-01 | 0.363 |
| R-HSA-210991 | Basigin interactions | 4.337959e-01 | 0.363 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.346533e-01 | 0.362 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.375514e-01 | 0.359 |
| R-HSA-983189 | Kinesins | 4.379689e-01 | 0.359 |
| R-HSA-2559583 | Cellular Senescence | 4.396258e-01 | 0.357 |
| R-HSA-112043 | PLC beta mediated events | 4.453097e-01 | 0.351 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 4.453097e-01 | 0.351 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 4.460584e-01 | 0.351 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 4.460584e-01 | 0.351 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 4.460584e-01 | 0.351 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 4.460584e-01 | 0.351 |
| R-HSA-76066 | RNA Polymerase III Transcription Initiation From Type 2 Promoter | 4.460584e-01 | 0.351 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 4.460584e-01 | 0.351 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 4.460584e-01 | 0.351 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 4.460584e-01 | 0.351 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 4.460584e-01 | 0.351 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 4.460584e-01 | 0.351 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 4.489210e-01 | 0.348 |
| R-HSA-5653656 | Vesicle-mediated transport | 4.493933e-01 | 0.347 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 4.523017e-01 | 0.345 |
| R-HSA-186797 | Signaling by PDGF | 4.525969e-01 | 0.344 |
| R-HSA-1268020 | Mitochondrial protein import | 4.525969e-01 | 0.344 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.525969e-01 | 0.344 |
| R-HSA-9707616 | Heme signaling | 4.525969e-01 | 0.344 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 4.538440e-01 | 0.343 |
| R-HSA-9938206 | Developmental Lineage of Mammary Stem Cells | 4.580560e-01 | 0.339 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 4.580560e-01 | 0.339 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 4.580560e-01 | 0.339 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 4.580560e-01 | 0.339 |
| R-HSA-76061 | RNA Polymerase III Transcription Initiation From Type 1 Promoter | 4.580560e-01 | 0.339 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 4.580560e-01 | 0.339 |
| R-HSA-9669938 | Signaling by KIT in disease | 4.580560e-01 | 0.339 |
| R-HSA-5652084 | Fructose metabolism | 4.580560e-01 | 0.339 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 4.580560e-01 | 0.339 |
| R-HSA-166208 | mTORC1-mediated signalling | 4.580560e-01 | 0.339 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 4.580560e-01 | 0.339 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 4.580560e-01 | 0.339 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 4.580560e-01 | 0.339 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 4.580560e-01 | 0.339 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 4.625113e-01 | 0.335 |
| R-HSA-2428924 | IGF1R signaling cascade | 4.670058e-01 | 0.331 |
| R-HSA-74751 | Insulin receptor signalling cascade | 4.670058e-01 | 0.331 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 4.697945e-01 | 0.328 |
| R-HSA-74182 | Ketone body metabolism | 4.697945e-01 | 0.328 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 4.697945e-01 | 0.328 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 4.697945e-01 | 0.328 |
| R-HSA-9018682 | Biosynthesis of maresins | 4.697945e-01 | 0.328 |
| R-HSA-3000170 | Syndecan interactions | 4.697945e-01 | 0.328 |
| R-HSA-1234174 | Cellular response to hypoxia | 4.741256e-01 | 0.324 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 4.741256e-01 | 0.324 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.758132e-01 | 0.323 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.807646e-01 | 0.318 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 4.811878e-01 | 0.318 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 4.812795e-01 | 0.318 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 4.812795e-01 | 0.318 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 4.812795e-01 | 0.318 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 4.812795e-01 | 0.318 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 4.812795e-01 | 0.318 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 4.812795e-01 | 0.318 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.857012e-01 | 0.314 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.879392e-01 | 0.312 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.879392e-01 | 0.312 |
| R-HSA-112040 | G-protein mediated events | 4.881914e-01 | 0.311 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 4.915430e-01 | 0.308 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 4.925164e-01 | 0.308 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 4.925164e-01 | 0.308 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 4.925164e-01 | 0.308 |
| R-HSA-420029 | Tight junction interactions | 4.925164e-01 | 0.308 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 4.925164e-01 | 0.308 |
| R-HSA-2160916 | Hyaluronan degradation | 4.925164e-01 | 0.308 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 4.925164e-01 | 0.308 |
| R-HSA-3214842 | HDMs demethylate histones | 4.925164e-01 | 0.308 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 4.925164e-01 | 0.308 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 4.925164e-01 | 0.308 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.934053e-01 | 0.307 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.934053e-01 | 0.307 |
| R-HSA-5218859 | Regulated Necrosis | 4.951357e-01 | 0.305 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.956653e-01 | 0.305 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 5.035105e-01 | 0.298 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 5.035105e-01 | 0.298 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 5.035105e-01 | 0.298 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 5.035105e-01 | 0.298 |
| R-HSA-5689901 | Metalloprotease DUBs | 5.035105e-01 | 0.298 |
| R-HSA-525793 | Myogenesis | 5.035105e-01 | 0.298 |
| R-HSA-9638630 | Attachment of bacteria to epithelial cells | 5.035105e-01 | 0.298 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 5.035105e-01 | 0.298 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 5.035105e-01 | 0.298 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 5.088436e-01 | 0.293 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 5.088436e-01 | 0.293 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.088436e-01 | 0.293 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.099882e-01 | 0.292 |
| R-HSA-446652 | Interleukin-1 family signaling | 5.099882e-01 | 0.292 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 5.142671e-01 | 0.289 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 5.142671e-01 | 0.289 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 5.142671e-01 | 0.289 |
| R-HSA-8949613 | Cristae formation | 5.142671e-01 | 0.289 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 5.142671e-01 | 0.289 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 5.142671e-01 | 0.289 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 5.142671e-01 | 0.289 |
| R-HSA-264876 | Insulin processing | 5.142671e-01 | 0.289 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 5.142671e-01 | 0.289 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 5.149744e-01 | 0.288 |
| R-HSA-3000178 | ECM proteoglycans | 5.156059e-01 | 0.288 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.190973e-01 | 0.285 |
| R-HSA-73887 | Death Receptor Signaling | 5.190973e-01 | 0.285 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 5.223065e-01 | 0.282 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.233181e-01 | 0.281 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 5.247913e-01 | 0.280 |
| R-HSA-167287 | HIV elongation arrest and recovery | 5.247913e-01 | 0.280 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 5.247913e-01 | 0.280 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 5.247913e-01 | 0.280 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 5.247913e-01 | 0.280 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 5.247913e-01 | 0.280 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 5.247913e-01 | 0.280 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 5.247913e-01 | 0.280 |
| R-HSA-9757110 | Prednisone ADME | 5.247913e-01 | 0.280 |
| R-HSA-9749641 | Aspirin ADME | 5.289447e-01 | 0.277 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 5.350882e-01 | 0.272 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 5.350882e-01 | 0.272 |
| R-HSA-420092 | Glucagon-type ligand receptors | 5.350882e-01 | 0.272 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 5.350882e-01 | 0.272 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 5.355201e-01 | 0.271 |
| R-HSA-8852135 | Protein ubiquitination | 5.420324e-01 | 0.266 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 5.420324e-01 | 0.266 |
| R-HSA-195721 | Signaling by WNT | 5.444250e-01 | 0.264 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 5.451625e-01 | 0.263 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 5.451625e-01 | 0.263 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 5.451625e-01 | 0.263 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 5.451625e-01 | 0.263 |
| R-HSA-112311 | Neurotransmitter clearance | 5.451625e-01 | 0.263 |
| R-HSA-5633007 | Regulation of TP53 Activity | 5.459340e-01 | 0.263 |
| R-HSA-5357801 | Programmed Cell Death | 5.462151e-01 | 0.263 |
| R-HSA-212436 | Generic Transcription Pathway | 5.537476e-01 | 0.257 |
| R-HSA-182971 | EGFR downregulation | 5.550191e-01 | 0.256 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 5.550191e-01 | 0.256 |
| R-HSA-399719 | Trafficking of AMPA receptors | 5.550191e-01 | 0.256 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 5.550191e-01 | 0.256 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.565890e-01 | 0.254 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.565890e-01 | 0.254 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.565890e-01 | 0.254 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.590735e-01 | 0.253 |
| R-HSA-4086400 | PCP/CE pathway | 5.611872e-01 | 0.251 |
| R-HSA-68875 | Mitotic Prophase | 5.616395e-01 | 0.251 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.646628e-01 | 0.248 |
| R-HSA-9937080 | Developmental Lineage of Multipotent Pancreatic Progenitor Cells | 5.646628e-01 | 0.248 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 5.646628e-01 | 0.248 |
| R-HSA-1296065 | Inwardly rectifying K+ channels | 5.646628e-01 | 0.248 |
| R-HSA-73886 | Chromosome Maintenance | 5.666550e-01 | 0.247 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 5.666550e-01 | 0.247 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.674438e-01 | 0.246 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 5.716354e-01 | 0.243 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 5.716354e-01 | 0.243 |
| R-HSA-5654738 | Signaling by FGFR2 | 5.736360e-01 | 0.241 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 5.740980e-01 | 0.241 |
| R-HSA-397795 | G-protein beta:gamma signalling | 5.740980e-01 | 0.241 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 5.740980e-01 | 0.241 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 5.740980e-01 | 0.241 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 5.740980e-01 | 0.241 |
| R-HSA-159418 | Recycling of bile acids and salts | 5.740980e-01 | 0.241 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.740980e-01 | 0.241 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 5.740980e-01 | 0.241 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.740980e-01 | 0.241 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 5.797635e-01 | 0.237 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.814893e-01 | 0.235 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.833293e-01 | 0.234 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 5.833293e-01 | 0.234 |
| R-HSA-2024101 | CS/DS degradation | 5.833293e-01 | 0.234 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 5.833293e-01 | 0.234 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 5.833293e-01 | 0.234 |
| R-HSA-416476 | G alpha (q) signalling events | 5.887955e-01 | 0.230 |
| R-HSA-73894 | DNA Repair | 5.910363e-01 | 0.228 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.911992e-01 | 0.228 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.911992e-01 | 0.228 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.911992e-01 | 0.228 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 5.923610e-01 | 0.227 |
| R-HSA-5696400 | Dual Incision in GG-NER | 5.923610e-01 | 0.227 |
| R-HSA-180746 | Nuclear import of Rev protein | 5.923610e-01 | 0.227 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 5.923610e-01 | 0.227 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 5.923610e-01 | 0.227 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 5.923610e-01 | 0.227 |
| R-HSA-2142845 | Hyaluronan metabolism | 5.923610e-01 | 0.227 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 5.923610e-01 | 0.227 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 5.923610e-01 | 0.227 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 5.923610e-01 | 0.227 |
| R-HSA-392518 | Signal amplification | 5.923610e-01 | 0.227 |
| R-HSA-5205647 | Mitophagy | 5.923610e-01 | 0.227 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 5.977575e-01 | 0.223 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 6.011976e-01 | 0.221 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 6.011976e-01 | 0.221 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 6.011976e-01 | 0.221 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 6.011976e-01 | 0.221 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 6.011976e-01 | 0.221 |
| R-HSA-169911 | Regulation of Apoptosis | 6.011976e-01 | 0.221 |
| R-HSA-381042 | PERK regulates gene expression | 6.011976e-01 | 0.221 |
| R-HSA-187687 | Signalling to ERKs | 6.011976e-01 | 0.221 |
| R-HSA-2559585 | Oncogene Induced Senescence | 6.011976e-01 | 0.221 |
| R-HSA-8951664 | Neddylation | 6.068066e-01 | 0.217 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 6.098431e-01 | 0.215 |
| R-HSA-74158 | RNA Polymerase III Transcription | 6.098431e-01 | 0.215 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 6.098431e-01 | 0.215 |
| R-HSA-1839126 | FGFR2 mutant receptor activation | 6.098431e-01 | 0.215 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 6.098431e-01 | 0.215 |
| R-HSA-111933 | Calmodulin induced events | 6.098431e-01 | 0.215 |
| R-HSA-111997 | CaM pathway | 6.098431e-01 | 0.215 |
| R-HSA-4641258 | Degradation of DVL | 6.183017e-01 | 0.209 |
| R-HSA-4641257 | Degradation of AXIN | 6.183017e-01 | 0.209 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 6.183017e-01 | 0.209 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 6.183017e-01 | 0.209 |
| R-HSA-8948216 | Collagen chain trimerization | 6.183017e-01 | 0.209 |
| R-HSA-196757 | Metabolism of folate and pterines | 6.183017e-01 | 0.209 |
| R-HSA-9843745 | Adipogenesis | 6.240235e-01 | 0.205 |
| R-HSA-5576891 | Cardiac conduction | 6.240235e-01 | 0.205 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.247673e-01 | 0.204 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 6.265774e-01 | 0.203 |
| R-HSA-9931953 | Biofilm formation | 6.265774e-01 | 0.203 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.319964e-01 | 0.199 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 6.346743e-01 | 0.197 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 6.346743e-01 | 0.197 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 6.346743e-01 | 0.197 |
| R-HSA-71336 | Pentose phosphate pathway | 6.346743e-01 | 0.197 |
| R-HSA-69541 | Stabilization of p53 | 6.346743e-01 | 0.197 |
| R-HSA-201556 | Signaling by ALK | 6.346743e-01 | 0.197 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 6.346743e-01 | 0.197 |
| R-HSA-112310 | Neurotransmitter release cycle | 6.374771e-01 | 0.196 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 6.425960e-01 | 0.192 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 6.425960e-01 | 0.192 |
| R-HSA-167169 | HIV Transcription Elongation | 6.425960e-01 | 0.192 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 6.425960e-01 | 0.192 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 6.425960e-01 | 0.192 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 6.425960e-01 | 0.192 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 6.425960e-01 | 0.192 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.476940e-01 | 0.189 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 6.503464e-01 | 0.187 |
| R-HSA-5423646 | Aflatoxin activation and detoxification | 6.503464e-01 | 0.187 |
| R-HSA-9694548 | Maturation of spike protein | 6.503464e-01 | 0.187 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 6.503464e-01 | 0.187 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 6.503464e-01 | 0.187 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 6.503464e-01 | 0.187 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 6.503464e-01 | 0.187 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 6.503464e-01 | 0.187 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 6.503464e-01 | 0.187 |
| R-HSA-9607240 | FLT3 Signaling | 6.503464e-01 | 0.187 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.506924e-01 | 0.187 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 6.535353e-01 | 0.185 |
| R-HSA-74752 | Signaling by Insulin receptor | 6.535353e-01 | 0.185 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 6.579293e-01 | 0.182 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 6.579293e-01 | 0.182 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 6.579293e-01 | 0.182 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 6.579293e-01 | 0.182 |
| R-HSA-9683701 | Translation of Structural Proteins | 6.579293e-01 | 0.182 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 6.579293e-01 | 0.182 |
| R-HSA-2029481 | FCGR activation | 6.587608e-01 | 0.181 |
| R-HSA-1474290 | Collagen formation | 6.639231e-01 | 0.178 |
| R-HSA-111996 | Ca-dependent events | 6.653481e-01 | 0.177 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 6.653481e-01 | 0.177 |
| R-HSA-165159 | MTOR signalling | 6.653481e-01 | 0.177 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 6.690225e-01 | 0.175 |
| R-HSA-1433557 | Signaling by SCF-KIT | 6.726065e-01 | 0.172 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 6.726065e-01 | 0.172 |
| R-HSA-8854214 | TBC/RABGAPs | 6.726065e-01 | 0.172 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 6.726065e-01 | 0.172 |
| R-HSA-5654743 | Signaling by FGFR4 | 6.726065e-01 | 0.172 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 6.758496e-01 | 0.170 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 6.790338e-01 | 0.168 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.790338e-01 | 0.168 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 6.797079e-01 | 0.168 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.800716e-01 | 0.167 |
| R-HSA-157579 | Telomere Maintenance | 6.839463e-01 | 0.165 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 6.839463e-01 | 0.165 |
| R-HSA-774815 | Nucleosome assembly | 6.866557e-01 | 0.163 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 6.866557e-01 | 0.163 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 6.866557e-01 | 0.163 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 6.866557e-01 | 0.163 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 6.866557e-01 | 0.163 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 6.866557e-01 | 0.163 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 6.866557e-01 | 0.163 |
| R-HSA-1489509 | DAG and IP3 signaling | 6.866557e-01 | 0.163 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 6.866557e-01 | 0.163 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 6.866557e-01 | 0.163 |
| R-HSA-9824272 | Somitogenesis | 6.866557e-01 | 0.163 |
| R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism | 6.866557e-01 | 0.163 |
| R-HSA-5654741 | Signaling by FGFR3 | 6.866557e-01 | 0.163 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 6.881220e-01 | 0.162 |
| R-HSA-190236 | Signaling by FGFR | 6.887972e-01 | 0.162 |
| R-HSA-422356 | Regulation of insulin secretion | 6.887972e-01 | 0.162 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 6.934532e-01 | 0.159 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 6.934532e-01 | 0.159 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 6.934532e-01 | 0.159 |
| R-HSA-9614085 | FOXO-mediated transcription | 6.935869e-01 | 0.159 |
| R-HSA-382556 | ABC-family proteins mediated transport | 6.983156e-01 | 0.156 |
| R-HSA-70171 | Glycolysis | 6.983156e-01 | 0.156 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 7.001036e-01 | 0.155 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.029839e-01 | 0.153 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.029839e-01 | 0.153 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 7.056860e-01 | 0.151 |
| R-HSA-5620924 | Intraflagellar transport | 7.066102e-01 | 0.151 |
| R-HSA-9634597 | GPER1 signaling | 7.066102e-01 | 0.151 |
| R-HSA-9031628 | NGF-stimulated transcription | 7.066102e-01 | 0.151 |
| R-HSA-597592 | Post-translational protein modification | 7.074996e-01 | 0.150 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.075921e-01 | 0.150 |
| R-HSA-1638074 | Keratan sulfate/keratin metabolism | 7.129760e-01 | 0.147 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 7.129760e-01 | 0.147 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 7.129760e-01 | 0.147 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 7.129760e-01 | 0.147 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.156060e-01 | 0.145 |
| R-HSA-111885 | Opioid Signalling | 7.166297e-01 | 0.145 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 7.192041e-01 | 0.143 |
| R-HSA-9833110 | RSV-host interactions | 7.210601e-01 | 0.142 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.216840e-01 | 0.142 |
| R-HSA-912446 | Meiotic recombination | 7.252973e-01 | 0.139 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 7.252973e-01 | 0.139 |
| R-HSA-5696398 | Nucleotide Excision Repair | 7.254320e-01 | 0.139 |
| R-HSA-1989781 | PPARA activates gene expression | 7.296944e-01 | 0.137 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 7.312588e-01 | 0.136 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 7.312588e-01 | 0.136 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 7.312588e-01 | 0.136 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.330925e-01 | 0.135 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 7.367676e-01 | 0.133 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 7.370912e-01 | 0.132 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 7.370912e-01 | 0.132 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 7.370912e-01 | 0.132 |
| R-HSA-8956320 | Nucleotide biosynthesis | 7.370912e-01 | 0.132 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 7.402491e-01 | 0.131 |
| R-HSA-156588 | Glucuronidation | 7.427974e-01 | 0.129 |
| R-HSA-877300 | Interferon gamma signaling | 7.436941e-01 | 0.129 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.471027e-01 | 0.127 |
| R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | 7.483801e-01 | 0.126 |
| R-HSA-9012852 | Signaling by NOTCH3 | 7.483801e-01 | 0.126 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.498760e-01 | 0.125 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 7.538419e-01 | 0.123 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 7.538419e-01 | 0.123 |
| R-HSA-193648 | NRAGE signals death through JNK | 7.538419e-01 | 0.123 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 7.591856e-01 | 0.120 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.591856e-01 | 0.120 |
| R-HSA-6782135 | Dual incision in TC-NER | 7.644135e-01 | 0.117 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 7.644135e-01 | 0.117 |
| R-HSA-191859 | snRNP Assembly | 7.695283e-01 | 0.114 |
| R-HSA-194441 | Metabolism of non-coding RNA | 7.695283e-01 | 0.114 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 7.695283e-01 | 0.114 |
| R-HSA-186712 | Regulation of beta-cell development | 7.695283e-01 | 0.114 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.745323e-01 | 0.111 |
| R-HSA-977443 | GABA receptor activation | 7.745323e-01 | 0.111 |
| R-HSA-351202 | Metabolism of polyamines | 7.745323e-01 | 0.111 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 7.745323e-01 | 0.111 |
| R-HSA-211976 | Endogenous sterols | 7.794280e-01 | 0.108 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 7.794280e-01 | 0.108 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.794280e-01 | 0.108 |
| R-HSA-1442490 | Collagen degradation | 7.794280e-01 | 0.108 |
| R-HSA-70326 | Glucose metabolism | 7.807683e-01 | 0.107 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 7.829351e-01 | 0.106 |
| R-HSA-6784531 | tRNA processing in the nucleus | 7.842177e-01 | 0.106 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.842177e-01 | 0.106 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 7.842177e-01 | 0.106 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 7.842177e-01 | 0.106 |
| R-HSA-418555 | G alpha (s) signalling events | 7.852341e-01 | 0.105 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.877331e-01 | 0.104 |
| R-HSA-9658195 | Leishmania infection | 7.877331e-01 | 0.104 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.881866e-01 | 0.103 |
| R-HSA-162906 | HIV Infection | 7.888147e-01 | 0.103 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 7.889036e-01 | 0.103 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 7.889036e-01 | 0.103 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.911055e-01 | 0.102 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.911055e-01 | 0.102 |
| R-HSA-211981 | Xenobiotics | 7.934881e-01 | 0.100 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 7.934881e-01 | 0.100 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 8.023614e-01 | 0.096 |
| R-HSA-5693606 | DNA Double Strand Break Response | 8.066544e-01 | 0.093 |
| R-HSA-196807 | Nicotinate metabolism | 8.066544e-01 | 0.093 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 8.066544e-01 | 0.093 |
| R-HSA-167172 | Transcription of the HIV genome | 8.108544e-01 | 0.091 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 8.108544e-01 | 0.091 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 8.108544e-01 | 0.091 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 8.140837e-01 | 0.089 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 8.189834e-01 | 0.087 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 8.189834e-01 | 0.087 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 8.189834e-01 | 0.087 |
| R-HSA-157118 | Signaling by NOTCH | 8.205003e-01 | 0.086 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 8.229164e-01 | 0.085 |
| R-HSA-8978934 | Metabolism of cofactors | 8.229164e-01 | 0.085 |
| R-HSA-5632684 | Hedgehog 'on' state | 8.229164e-01 | 0.085 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 8.229164e-01 | 0.085 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 8.267641e-01 | 0.083 |
| R-HSA-74259 | Purine catabolism | 8.267641e-01 | 0.083 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 8.305284e-01 | 0.081 |
| R-HSA-4086398 | Ca2+ pathway | 8.305284e-01 | 0.081 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 8.305284e-01 | 0.081 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 8.342112e-01 | 0.079 |
| R-HSA-1226099 | Signaling by FGFR in disease | 8.342112e-01 | 0.079 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 8.342112e-01 | 0.079 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.346428e-01 | 0.078 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 8.378141e-01 | 0.077 |
| R-HSA-109582 | Hemostasis | 8.423509e-01 | 0.075 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 8.447875e-01 | 0.073 |
| R-HSA-9694635 | Translation of Structural Proteins | 8.447875e-01 | 0.073 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.450428e-01 | 0.073 |
| R-HSA-163685 | Integration of energy metabolism | 8.480492e-01 | 0.072 |
| R-HSA-5619084 | ABC transporter disorders | 8.481612e-01 | 0.072 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 8.546909e-01 | 0.068 |
| R-HSA-6807070 | PTEN Regulation | 8.556121e-01 | 0.068 |
| R-HSA-977225 | Amyloid fiber formation | 8.578500e-01 | 0.067 |
| R-HSA-9018677 | Biosynthesis of DHA-derived SPMs | 8.578500e-01 | 0.067 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.580581e-01 | 0.066 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 8.609405e-01 | 0.065 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 8.609405e-01 | 0.065 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 8.639641e-01 | 0.064 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 8.639641e-01 | 0.064 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 8.651624e-01 | 0.063 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 8.669221e-01 | 0.062 |
| R-HSA-72172 | mRNA Splicing | 8.681648e-01 | 0.061 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 8.726471e-01 | 0.059 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 8.754168e-01 | 0.058 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.762863e-01 | 0.057 |
| R-HSA-9645723 | Diseases of programmed cell death | 8.807773e-01 | 0.055 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.825490e-01 | 0.054 |
| R-HSA-73884 | Base Excision Repair | 8.859078e-01 | 0.053 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 8.859078e-01 | 0.053 |
| R-HSA-388396 | GPCR downstream signalling | 8.890277e-01 | 0.051 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 8.913438e-01 | 0.050 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.916933e-01 | 0.050 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 8.931937e-01 | 0.049 |
| R-HSA-162587 | HIV Life Cycle | 8.960403e-01 | 0.048 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 9.000155e-01 | 0.046 |
| R-HSA-1296071 | Potassium Channels | 9.043202e-01 | 0.044 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.097428e-01 | 0.041 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 9.104333e-01 | 0.041 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 9.104333e-01 | 0.041 |
| R-HSA-5610787 | Hedgehog 'off' state | 9.123831e-01 | 0.040 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 9.128312e-01 | 0.040 |
| R-HSA-372790 | Signaling by GPCR | 9.147382e-01 | 0.039 |
| R-HSA-1483255 | PI Metabolism | 9.161567e-01 | 0.038 |
| R-HSA-72306 | tRNA processing | 9.188085e-01 | 0.037 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 9.197683e-01 | 0.036 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 9.215155e-01 | 0.035 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 9.215155e-01 | 0.035 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 9.215155e-01 | 0.035 |
| R-HSA-418346 | Platelet homeostasis | 9.248968e-01 | 0.034 |
| R-HSA-211000 | Gene Silencing by RNA | 9.265326e-01 | 0.033 |
| R-HSA-611105 | Respiratory electron transport | 9.296269e-01 | 0.032 |
| R-HSA-5419276 | Mitochondrial translation termination | 9.296984e-01 | 0.032 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 9.312299e-01 | 0.031 |
| R-HSA-6803157 | Antimicrobial peptides | 9.327281e-01 | 0.030 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 9.341938e-01 | 0.030 |
| R-HSA-1483249 | Inositol phosphate metabolism | 9.341938e-01 | 0.030 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 9.370303e-01 | 0.028 |
| R-HSA-375276 | Peptide ligand-binding receptors | 9.390754e-01 | 0.027 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 9.397449e-01 | 0.027 |
| R-HSA-9007101 | Rab regulation of trafficking | 9.435995e-01 | 0.025 |
| R-HSA-2980736 | Peptide hormone metabolism | 9.435995e-01 | 0.025 |
| R-HSA-9609690 | HCMV Early Events | 9.492013e-01 | 0.023 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 9.505866e-01 | 0.022 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.544855e-01 | 0.020 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.553135e-01 | 0.020 |
| R-HSA-8956319 | Nucleotide catabolism | 9.576546e-01 | 0.019 |
| R-HSA-418594 | G alpha (i) signalling events | 9.578771e-01 | 0.019 |
| R-HSA-9748784 | Drug ADME | 9.667560e-01 | 0.015 |
| R-HSA-5368287 | Mitochondrial translation | 9.667799e-01 | 0.015 |
| R-HSA-5358351 | Signaling by Hedgehog | 9.667799e-01 | 0.015 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 9.675051e-01 | 0.014 |
| R-HSA-1483257 | Phospholipid metabolism | 9.688565e-01 | 0.014 |
| R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) | 9.709011e-01 | 0.013 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.734325e-01 | 0.012 |
| R-HSA-9758941 | Gastrulation | 9.745123e-01 | 0.011 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 9.750692e-01 | 0.011 |
| R-HSA-15869 | Metabolism of nucleotides | 9.762664e-01 | 0.010 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.767094e-01 | 0.010 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 9.775716e-01 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.789295e-01 | 0.009 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.796827e-01 | 0.009 |
| R-HSA-211859 | Biological oxidations | 9.797942e-01 | 0.009 |
| R-HSA-500792 | GPCR ligand binding | 9.804777e-01 | 0.009 |
| R-HSA-9609646 | HCMV Infection | 9.817895e-01 | 0.008 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 9.878415e-01 | 0.005 |
| R-HSA-3781865 | Diseases of glycosylation | 9.885027e-01 | 0.005 |
| R-HSA-5668914 | Diseases of metabolism | 9.887930e-01 | 0.005 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.905047e-01 | 0.004 |
| R-HSA-1630316 | Glycosaminoglycan metabolism | 9.905802e-01 | 0.004 |
| R-HSA-428157 | Sphingolipid metabolism | 9.921103e-01 | 0.003 |
| R-HSA-9640148 | Infection with Enterobacteria | 9.924524e-01 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 9.933574e-01 | 0.003 |
| R-HSA-8957322 | Metabolism of steroids | 9.956589e-01 | 0.002 |
| R-HSA-8978868 | Fatty acid metabolism | 9.956828e-01 | 0.002 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.972201e-01 | 0.001 |
| R-HSA-556833 | Metabolism of lipids | 9.999874e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999934e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
JNK2 |
0.898 | 0.678 | 1 | 0.911 |
TNIK |
0.895 | 0.121 | 3 | 0.901 |
GAK |
0.894 | -0.039 | 1 | 0.726 |
JNK3 |
0.894 | 0.651 | 1 | 0.922 |
MINK |
0.893 | 0.046 | 1 | 0.695 |
VRK2 |
0.893 | 0.003 | 1 | 0.808 |
PKR |
0.893 | 0.049 | 1 | 0.738 |
P38A |
0.891 | 0.622 | 1 | 0.922 |
KHS1 |
0.890 | 0.096 | 1 | 0.692 |
HGK |
0.890 | 0.083 | 3 | 0.906 |
P38B |
0.890 | 0.639 | 1 | 0.899 |
LRRK2 |
0.890 | -0.010 | 2 | 0.889 |
VRK1 |
0.889 | -0.105 | 2 | 0.860 |
GCK |
0.888 | 0.021 | 1 | 0.712 |
KHS2 |
0.888 | 0.128 | 1 | 0.708 |
EEF2K |
0.888 | 0.072 | 3 | 0.900 |
TAO2 |
0.888 | 0.051 | 2 | 0.900 |
NLK |
0.888 | 0.600 | 1 | 0.927 |
TAK1 |
0.887 | -0.133 | 1 | 0.723 |
ASK1 |
0.887 | -0.096 | 1 | 0.689 |
NEK1 |
0.886 | -0.051 | 1 | 0.700 |
MAP3K15 |
0.885 | -0.018 | 1 | 0.702 |
MST3 |
0.885 | 0.120 | 2 | 0.879 |
P38G |
0.885 | 0.674 | 1 | 0.870 |
MYO3A |
0.884 | 0.037 | 1 | 0.695 |
MEKK2 |
0.884 | -0.032 | 2 | 0.852 |
CDK5 |
0.884 | 0.678 | 1 | 0.926 |
MYO3B |
0.884 | 0.056 | 2 | 0.882 |
PRP4 |
0.883 | 0.394 | -3 | 0.818 |
TAO3 |
0.883 | 0.070 | 1 | 0.729 |
MST1 |
0.882 | -0.072 | 1 | 0.696 |
HPK1 |
0.882 | 0.028 | 1 | 0.700 |
YSK1 |
0.882 | 0.031 | 2 | 0.870 |
MEKK6 |
0.881 | -0.022 | 1 | 0.714 |
TTK |
0.881 | -0.027 | -2 | 0.854 |
NEK5 |
0.880 | -0.061 | 1 | 0.722 |
NIK |
0.880 | -0.008 | -3 | 0.898 |
MST2 |
0.880 | -0.089 | 1 | 0.710 |
BMPR2 |
0.879 | -0.130 | -2 | 0.931 |
PDK1 |
0.879 | -0.087 | 1 | 0.722 |
MEK5 |
0.879 | -0.174 | 2 | 0.859 |
ERK2 |
0.879 | 0.612 | 1 | 0.916 |
OSR1 |
0.878 | -0.023 | 2 | 0.850 |
MEK1 |
0.878 | -0.177 | 2 | 0.861 |
BRAF |
0.878 | -0.131 | -4 | 0.855 |
LKB1 |
0.878 | -0.059 | -3 | 0.871 |
CDK1 |
0.877 | 0.668 | 1 | 0.907 |
NEK4 |
0.877 | -0.070 | 1 | 0.695 |
P38D |
0.877 | 0.645 | 1 | 0.878 |
BIKE |
0.876 | -0.034 | 1 | 0.611 |
MPSK1 |
0.876 | 0.057 | 1 | 0.700 |
ERK1 |
0.876 | 0.635 | 1 | 0.899 |
CDK6 |
0.875 | 0.640 | 1 | 0.899 |
MEKK1 |
0.875 | -0.104 | 1 | 0.729 |
NEK11 |
0.873 | -0.099 | 1 | 0.719 |
DAPK2 |
0.872 | -0.088 | -3 | 0.874 |
PRPK |
0.872 | -0.067 | -1 | 0.898 |
ICK |
0.872 | 0.250 | -3 | 0.825 |
CDK4 |
0.872 | 0.633 | 1 | 0.902 |
ZAK |
0.871 | -0.066 | 1 | 0.708 |
ANKRD3 |
0.871 | -0.138 | 1 | 0.758 |
ALK4 |
0.871 | -0.046 | -2 | 0.870 |
NEK8 |
0.870 | -0.139 | 2 | 0.864 |
CDK16 |
0.870 | 0.676 | 1 | 0.872 |
CDK14 |
0.870 | 0.627 | 1 | 0.907 |
CAMKK1 |
0.870 | -0.200 | -2 | 0.801 |
HIPK1 |
0.870 | 0.500 | 1 | 0.932 |
STLK3 |
0.870 | -0.206 | 1 | 0.682 |
CDKL1 |
0.869 | 0.109 | -3 | 0.786 |
CAMKK2 |
0.869 | -0.186 | -2 | 0.793 |
CDK3 |
0.869 | 0.632 | 1 | 0.875 |
LOK |
0.869 | -0.002 | -2 | 0.817 |
JNK1 |
0.869 | 0.566 | 1 | 0.896 |
CAMLCK |
0.869 | -0.079 | -2 | 0.870 |
MEK2 |
0.869 | -0.232 | 2 | 0.840 |
PBK |
0.868 | -0.057 | 1 | 0.651 |
YSK4 |
0.868 | -0.100 | 1 | 0.685 |
MOS |
0.867 | -0.022 | 1 | 0.757 |
DLK |
0.867 | -0.227 | 1 | 0.748 |
AAK1 |
0.867 | 0.009 | 1 | 0.529 |
CDK17 |
0.867 | 0.662 | 1 | 0.866 |
ERK5 |
0.867 | 0.302 | 1 | 0.842 |
CDK2 |
0.866 | 0.524 | 1 | 0.919 |
ATR |
0.866 | -0.010 | 1 | 0.766 |
TAO1 |
0.866 | -0.003 | 1 | 0.665 |
MLK2 |
0.865 | -0.045 | 2 | 0.870 |
CDK18 |
0.865 | 0.669 | 1 | 0.892 |
ALPHAK3 |
0.865 | -0.143 | -1 | 0.800 |
MEKK3 |
0.865 | -0.164 | 1 | 0.724 |
ERK7 |
0.865 | 0.278 | 2 | 0.615 |
CAMK1B |
0.864 | -0.069 | -3 | 0.868 |
CDK13 |
0.863 | 0.642 | 1 | 0.916 |
MAK |
0.862 | 0.383 | -2 | 0.760 |
CDK12 |
0.861 | 0.639 | 1 | 0.908 |
HIPK3 |
0.861 | 0.467 | 1 | 0.925 |
DMPK1 |
0.861 | 0.002 | -3 | 0.756 |
MOK |
0.859 | 0.340 | 1 | 0.881 |
ALK2 |
0.859 | -0.071 | -2 | 0.843 |
LATS1 |
0.859 | -0.033 | -3 | 0.852 |
HRI |
0.858 | -0.132 | -2 | 0.889 |
IRAK4 |
0.858 | -0.018 | 1 | 0.692 |
TGFBR1 |
0.858 | -0.025 | -2 | 0.839 |
NEK9 |
0.858 | -0.089 | 2 | 0.886 |
DYRK2 |
0.858 | 0.517 | 1 | 0.931 |
PERK |
0.858 | -0.148 | -2 | 0.871 |
CDK7 |
0.857 | 0.612 | 1 | 0.929 |
MLK1 |
0.857 | -0.044 | 2 | 0.859 |
HASPIN |
0.857 | 0.045 | -1 | 0.730 |
SMMLCK |
0.857 | -0.105 | -3 | 0.815 |
NEK3 |
0.856 | -0.064 | 1 | 0.692 |
ROCK2 |
0.856 | -0.022 | -3 | 0.788 |
CDK8 |
0.856 | 0.611 | 1 | 0.927 |
CDK9 |
0.856 | 0.609 | 1 | 0.918 |
WNK4 |
0.856 | -0.071 | -2 | 0.928 |
PASK |
0.856 | -0.107 | -3 | 0.843 |
CLK3 |
0.855 | 0.437 | 1 | 0.885 |
CDK10 |
0.855 | 0.621 | 1 | 0.902 |
WNK1 |
0.855 | 0.052 | -2 | 0.926 |
NEK2 |
0.855 | -0.044 | 2 | 0.869 |
CHAK2 |
0.855 | 0.021 | -1 | 0.879 |
BMPR1B |
0.855 | 0.020 | 1 | 0.669 |
DYRK1A |
0.854 | 0.408 | 1 | 0.942 |
RAF1 |
0.854 | -0.187 | 1 | 0.730 |
MST4 |
0.854 | 0.138 | 2 | 0.908 |
PKCD |
0.852 | 0.088 | 2 | 0.853 |
MLK3 |
0.852 | 0.068 | 2 | 0.808 |
DAPK3 |
0.852 | -0.097 | -3 | 0.797 |
SLK |
0.852 | -0.062 | -2 | 0.765 |
COT |
0.852 | 0.060 | 2 | 0.892 |
CDKL5 |
0.852 | 0.141 | -3 | 0.775 |
SKMLCK |
0.852 | -0.051 | -2 | 0.882 |
TLK2 |
0.852 | -0.120 | 1 | 0.712 |
PDHK4 |
0.851 | -0.204 | 1 | 0.774 |
PINK1 |
0.851 | 0.050 | 1 | 0.814 |
MTOR |
0.851 | 0.194 | 1 | 0.792 |
CAMK2G |
0.851 | -0.073 | 2 | 0.850 |
ACVR2A |
0.850 | -0.082 | -2 | 0.819 |
HIPK2 |
0.850 | 0.562 | 1 | 0.901 |
ACVR2B |
0.850 | -0.089 | -2 | 0.833 |
PKN3 |
0.849 | -0.009 | -3 | 0.824 |
PLK1 |
0.849 | -0.133 | -2 | 0.853 |
MASTL |
0.849 | -0.256 | -2 | 0.883 |
DYRK1B |
0.849 | 0.495 | 1 | 0.907 |
PDHK1 |
0.848 | -0.188 | 1 | 0.756 |
MLK4 |
0.848 | -0.027 | 2 | 0.777 |
DNAPK |
0.847 | 0.033 | 1 | 0.675 |
RIPK1 |
0.847 | -0.208 | 1 | 0.717 |
GRK5 |
0.847 | -0.169 | -3 | 0.884 |
DSTYK |
0.846 | -0.050 | 2 | 0.915 |
TSSK2 |
0.846 | -0.066 | -5 | 0.877 |
PKN2 |
0.846 | 0.028 | -3 | 0.849 |
TLK1 |
0.846 | -0.177 | -2 | 0.863 |
CHAK1 |
0.845 | -0.051 | 2 | 0.824 |
AMPKA1 |
0.845 | -0.037 | -3 | 0.862 |
HIPK4 |
0.845 | 0.328 | 1 | 0.899 |
NUAK2 |
0.845 | 0.039 | -3 | 0.841 |
SRPK1 |
0.845 | 0.302 | -3 | 0.728 |
CLK4 |
0.845 | 0.257 | -3 | 0.759 |
CDK19 |
0.844 | 0.609 | 1 | 0.910 |
RIPK3 |
0.844 | -0.104 | 3 | 0.790 |
IRE1 |
0.844 | 0.025 | 1 | 0.692 |
BUB1 |
0.844 | 0.011 | -5 | 0.801 |
SMG1 |
0.844 | 0.000 | 1 | 0.724 |
GRK7 |
0.843 | -0.002 | 1 | 0.690 |
DCAMKL1 |
0.843 | -0.035 | -3 | 0.787 |
PIM1 |
0.842 | 0.019 | -3 | 0.772 |
GRK6 |
0.842 | -0.151 | 1 | 0.724 |
IRE2 |
0.842 | 0.015 | 2 | 0.804 |
PKCA |
0.842 | 0.097 | 2 | 0.800 |
ROCK1 |
0.841 | -0.049 | -3 | 0.753 |
DYRK3 |
0.841 | 0.347 | 1 | 0.922 |
ULK2 |
0.841 | -0.101 | 2 | 0.830 |
SRPK3 |
0.840 | 0.196 | -3 | 0.698 |
CDC7 |
0.840 | -0.074 | 1 | 0.718 |
BMPR1A |
0.840 | -0.035 | 1 | 0.650 |
GSK3A |
0.840 | 0.160 | 4 | 0.450 |
NEK7 |
0.839 | -0.120 | -3 | 0.867 |
PIM3 |
0.839 | -0.030 | -3 | 0.829 |
TGFBR2 |
0.839 | -0.042 | -2 | 0.820 |
CLK1 |
0.839 | 0.317 | -3 | 0.738 |
PIM2 |
0.838 | -0.011 | -3 | 0.735 |
TSSK1 |
0.838 | -0.020 | -3 | 0.880 |
PKCZ |
0.838 | 0.032 | 2 | 0.839 |
NEK6 |
0.838 | 0.007 | -2 | 0.909 |
MARK4 |
0.838 | -0.041 | 4 | 0.846 |
DYRK4 |
0.838 | 0.514 | 1 | 0.913 |
DCAMKL2 |
0.838 | -0.060 | -3 | 0.815 |
DAPK1 |
0.838 | -0.121 | -3 | 0.775 |
WNK3 |
0.837 | -0.198 | 1 | 0.722 |
PKCH |
0.837 | 0.026 | 2 | 0.785 |
CHK1 |
0.836 | -0.104 | -3 | 0.833 |
DRAK1 |
0.836 | -0.129 | 1 | 0.676 |
GSK3B |
0.836 | 0.029 | 4 | 0.443 |
TBK1 |
0.835 | -0.151 | 1 | 0.648 |
MRCKB |
0.835 | -0.036 | -3 | 0.735 |
PKCB |
0.835 | 0.089 | 2 | 0.803 |
IRAK1 |
0.834 | -0.246 | -1 | 0.808 |
ATM |
0.834 | -0.042 | 1 | 0.707 |
P70S6KB |
0.834 | -0.063 | -3 | 0.794 |
HUNK |
0.834 | -0.201 | 2 | 0.806 |
SGK3 |
0.834 | -0.021 | -3 | 0.758 |
CAMK2D |
0.834 | -0.070 | -3 | 0.847 |
MRCKA |
0.833 | -0.062 | -3 | 0.753 |
AMPKA2 |
0.833 | -0.036 | -3 | 0.825 |
PLK3 |
0.832 | -0.150 | 2 | 0.779 |
PKCG |
0.830 | 0.061 | 2 | 0.799 |
CRIK |
0.830 | -0.065 | -3 | 0.681 |
GRK2 |
0.830 | -0.114 | -2 | 0.751 |
PKCE |
0.829 | 0.074 | 2 | 0.787 |
MELK |
0.828 | -0.074 | -3 | 0.812 |
AKT2 |
0.828 | -0.007 | -3 | 0.669 |
TTBK2 |
0.828 | -0.206 | 2 | 0.746 |
PKCI |
0.827 | 0.026 | 2 | 0.811 |
IKKE |
0.827 | -0.179 | 1 | 0.645 |
QIK |
0.827 | -0.090 | -3 | 0.846 |
NIM1 |
0.826 | -0.054 | 3 | 0.800 |
PKCT |
0.825 | 0.014 | 2 | 0.798 |
STK33 |
0.825 | -0.131 | 2 | 0.647 |
RIPK2 |
0.824 | -0.280 | 1 | 0.670 |
MYLK4 |
0.824 | -0.107 | -2 | 0.773 |
PAK1 |
0.823 | -0.089 | -2 | 0.791 |
RSK2 |
0.823 | -0.021 | -3 | 0.756 |
P90RSK |
0.823 | -0.046 | -3 | 0.757 |
PAK2 |
0.822 | -0.164 | -2 | 0.778 |
SSTK |
0.822 | -0.049 | 4 | 0.826 |
NDR1 |
0.822 | -0.056 | -3 | 0.837 |
PLK4 |
0.822 | -0.112 | 2 | 0.639 |
MARK2 |
0.821 | -0.071 | 4 | 0.745 |
CHK2 |
0.821 | -0.075 | -3 | 0.615 |
CAMK4 |
0.821 | -0.178 | -3 | 0.830 |
ULK1 |
0.820 | -0.183 | -3 | 0.846 |
AKT1 |
0.820 | -0.018 | -3 | 0.693 |
KIS |
0.820 | 0.560 | 1 | 0.934 |
PAK3 |
0.820 | -0.119 | -2 | 0.794 |
SRPK2 |
0.820 | 0.223 | -3 | 0.645 |
SGK1 |
0.820 | -0.028 | -3 | 0.579 |
MAPKAPK3 |
0.820 | -0.084 | -3 | 0.772 |
CAMK2B |
0.820 | -0.046 | 2 | 0.817 |
PRKD3 |
0.819 | -0.045 | -3 | 0.734 |
MNK2 |
0.819 | 0.008 | -2 | 0.809 |
CLK2 |
0.819 | 0.316 | -3 | 0.736 |
MNK1 |
0.819 | 0.011 | -2 | 0.819 |
GCN2 |
0.819 | -0.184 | 2 | 0.843 |
GRK1 |
0.818 | -0.061 | -2 | 0.827 |
QSK |
0.818 | -0.046 | 4 | 0.825 |
IKKB |
0.818 | -0.203 | -2 | 0.808 |
PDHK3_TYR |
0.818 | 0.140 | 4 | 0.894 |
PHKG1 |
0.816 | -0.020 | -3 | 0.832 |
PRKD1 |
0.816 | -0.023 | -3 | 0.816 |
GRK4 |
0.816 | -0.227 | -2 | 0.868 |
AURB |
0.816 | -0.054 | -2 | 0.642 |
BCKDK |
0.815 | -0.178 | -1 | 0.824 |
CAMK2A |
0.815 | -0.038 | 2 | 0.831 |
CAMK1D |
0.815 | -0.104 | -3 | 0.678 |
PKG2 |
0.814 | -0.025 | -2 | 0.675 |
MARK1 |
0.814 | -0.115 | 4 | 0.801 |
PKACG |
0.814 | -0.058 | -2 | 0.757 |
CAMK1G |
0.814 | -0.112 | -3 | 0.752 |
NUAK1 |
0.814 | -0.032 | -3 | 0.791 |
MARK3 |
0.814 | -0.055 | 4 | 0.780 |
PLK2 |
0.814 | -0.109 | -3 | 0.812 |
RSK3 |
0.813 | -0.052 | -3 | 0.750 |
PKMYT1_TYR |
0.812 | 0.102 | 3 | 0.873 |
TESK1_TYR |
0.812 | 0.028 | 3 | 0.901 |
IKKA |
0.812 | -0.115 | -2 | 0.801 |
LIMK2_TYR |
0.811 | 0.146 | -3 | 0.916 |
LATS2 |
0.810 | -0.044 | -5 | 0.797 |
PRKD2 |
0.809 | 0.001 | -3 | 0.763 |
SBK |
0.809 | 0.004 | -3 | 0.538 |
NDR2 |
0.808 | -0.018 | -3 | 0.842 |
PKN1 |
0.808 | -0.024 | -3 | 0.714 |
MAP2K4_TYR |
0.808 | -0.071 | -1 | 0.908 |
MAP2K7_TYR |
0.808 | -0.141 | 2 | 0.885 |
SIK |
0.807 | -0.063 | -3 | 0.762 |
PDHK4_TYR |
0.807 | -0.009 | 2 | 0.898 |
BMPR2_TYR |
0.805 | -0.031 | -1 | 0.874 |
RSK4 |
0.805 | -0.048 | -3 | 0.719 |
MAP2K6_TYR |
0.805 | -0.074 | -1 | 0.897 |
AURC |
0.805 | 0.001 | -2 | 0.641 |
PINK1_TYR |
0.805 | -0.149 | 1 | 0.761 |
CK1D |
0.804 | -0.024 | -3 | 0.513 |
MSK2 |
0.804 | -0.129 | -3 | 0.720 |
TTBK1 |
0.804 | -0.198 | 2 | 0.659 |
MSK1 |
0.804 | -0.102 | -3 | 0.731 |
LIMK1_TYR |
0.803 | -0.031 | 2 | 0.895 |
AURA |
0.802 | -0.091 | -2 | 0.603 |
PDHK1_TYR |
0.802 | -0.127 | -1 | 0.901 |
P70S6K |
0.802 | -0.115 | -3 | 0.692 |
CAMK1A |
0.802 | -0.095 | -3 | 0.637 |
TYK2 |
0.801 | -0.128 | 1 | 0.721 |
SNRK |
0.801 | -0.232 | 2 | 0.706 |
PHKG2 |
0.801 | -0.024 | -3 | 0.810 |
PKACB |
0.800 | -0.020 | -2 | 0.668 |
ROS1 |
0.800 | -0.072 | 3 | 0.806 |
BRSK2 |
0.799 | -0.117 | -3 | 0.827 |
MAPKAPK2 |
0.799 | -0.058 | -3 | 0.715 |
RET |
0.799 | -0.145 | 1 | 0.735 |
JAK2 |
0.799 | -0.110 | 1 | 0.736 |
MST1R |
0.799 | -0.119 | 3 | 0.825 |
GRK3 |
0.798 | -0.122 | -2 | 0.701 |
PAK6 |
0.798 | -0.016 | -2 | 0.703 |
AKT3 |
0.798 | -0.022 | -3 | 0.595 |
TYRO3 |
0.798 | -0.114 | 3 | 0.825 |
TNNI3K_TYR |
0.797 | 0.064 | 1 | 0.744 |
CSF1R |
0.797 | -0.091 | 3 | 0.813 |
EPHA6 |
0.795 | -0.091 | -1 | 0.863 |
CK1A2 |
0.795 | -0.051 | -3 | 0.508 |
BRSK1 |
0.794 | -0.111 | -3 | 0.792 |
CK1E |
0.793 | -0.040 | -3 | 0.562 |
TXK |
0.793 | -0.015 | 1 | 0.713 |
JAK1 |
0.792 | -0.028 | 1 | 0.682 |
DDR1 |
0.792 | -0.185 | 4 | 0.835 |
CK2A2 |
0.792 | -0.031 | 1 | 0.590 |
MAPKAPK5 |
0.792 | -0.190 | -3 | 0.699 |
YANK3 |
0.792 | -0.097 | 2 | 0.420 |
NEK10_TYR |
0.791 | -0.071 | 1 | 0.628 |
FAM20C |
0.791 | 0.025 | 2 | 0.631 |
YES1 |
0.791 | -0.094 | -1 | 0.881 |
EPHB4 |
0.791 | -0.148 | -1 | 0.856 |
JAK3 |
0.790 | -0.150 | 1 | 0.719 |
ABL2 |
0.790 | -0.105 | -1 | 0.851 |
FGR |
0.790 | -0.164 | 1 | 0.718 |
PDGFRB |
0.789 | -0.175 | 3 | 0.831 |
TNK1 |
0.789 | -0.062 | 3 | 0.798 |
PKACA |
0.789 | -0.051 | -2 | 0.609 |
TNK2 |
0.788 | -0.099 | 3 | 0.765 |
HCK |
0.788 | -0.121 | -1 | 0.856 |
ITK |
0.788 | -0.093 | -1 | 0.843 |
WEE1_TYR |
0.788 | -0.018 | -1 | 0.807 |
ABL1 |
0.787 | -0.112 | -1 | 0.851 |
LCK |
0.787 | -0.052 | -1 | 0.851 |
FER |
0.786 | -0.227 | 1 | 0.733 |
KDR |
0.786 | -0.103 | 3 | 0.783 |
FGFR2 |
0.786 | -0.145 | 3 | 0.815 |
YANK2 |
0.786 | -0.109 | 2 | 0.441 |
KIT |
0.785 | -0.161 | 3 | 0.818 |
FGFR1 |
0.785 | -0.120 | 3 | 0.786 |
INSRR |
0.785 | -0.186 | 3 | 0.778 |
FLT3 |
0.785 | -0.174 | 3 | 0.823 |
CK2A1 |
0.784 | -0.044 | 1 | 0.575 |
BLK |
0.784 | -0.053 | -1 | 0.849 |
TEK |
0.783 | -0.122 | 3 | 0.765 |
AXL |
0.783 | -0.156 | 3 | 0.792 |
SRMS |
0.783 | -0.192 | 1 | 0.717 |
PDGFRA |
0.782 | -0.225 | 3 | 0.826 |
TEC |
0.781 | -0.105 | -1 | 0.803 |
EPHB1 |
0.781 | -0.205 | 1 | 0.721 |
EPHA4 |
0.780 | -0.165 | 2 | 0.772 |
PAK5 |
0.780 | -0.094 | -2 | 0.634 |
BMX |
0.779 | -0.104 | -1 | 0.765 |
BTK |
0.779 | -0.197 | -1 | 0.826 |
MERTK |
0.779 | -0.159 | 3 | 0.780 |
PRKX |
0.778 | 0.012 | -3 | 0.669 |
EPHB3 |
0.778 | -0.205 | -1 | 0.840 |
MET |
0.778 | -0.172 | 3 | 0.788 |
ALK |
0.778 | -0.184 | 3 | 0.742 |
PTK6 |
0.777 | -0.224 | -1 | 0.797 |
EPHB2 |
0.776 | -0.193 | -1 | 0.834 |
LTK |
0.775 | -0.192 | 3 | 0.761 |
FLT1 |
0.774 | -0.186 | -1 | 0.829 |
ERBB2 |
0.774 | -0.222 | 1 | 0.683 |
FRK |
0.773 | -0.154 | -1 | 0.862 |
DDR2 |
0.773 | -0.081 | 3 | 0.766 |
FGFR3 |
0.773 | -0.178 | 3 | 0.789 |
FYN |
0.773 | -0.108 | -1 | 0.820 |
LYN |
0.773 | -0.143 | 3 | 0.751 |
EPHA7 |
0.772 | -0.167 | 2 | 0.782 |
INSR |
0.772 | -0.208 | 3 | 0.756 |
NTRK2 |
0.772 | -0.256 | 3 | 0.779 |
EPHA1 |
0.771 | -0.183 | 3 | 0.771 |
NTRK1 |
0.771 | -0.299 | -1 | 0.841 |
FLT4 |
0.771 | -0.229 | 3 | 0.783 |
NTRK3 |
0.770 | -0.200 | -1 | 0.793 |
MATK |
0.769 | -0.147 | -1 | 0.774 |
EPHA3 |
0.768 | -0.225 | 2 | 0.753 |
PTK2B |
0.768 | -0.129 | -1 | 0.837 |
PAK4 |
0.768 | -0.093 | -2 | 0.634 |
PKG1 |
0.767 | -0.091 | -2 | 0.587 |
CK1G1 |
0.766 | -0.072 | -3 | 0.560 |
SRC |
0.765 | -0.153 | -1 | 0.832 |
EGFR |
0.765 | -0.150 | 1 | 0.612 |
CSK |
0.764 | -0.202 | 2 | 0.784 |
EPHA8 |
0.761 | -0.190 | -1 | 0.808 |
FGFR4 |
0.761 | -0.171 | -1 | 0.796 |
MUSK |
0.760 | -0.160 | 1 | 0.586 |
EPHA5 |
0.760 | -0.219 | 2 | 0.757 |
PTK2 |
0.756 | -0.111 | -1 | 0.761 |
IGF1R |
0.752 | -0.238 | 3 | 0.696 |
SYK |
0.751 | -0.154 | -1 | 0.753 |
CK1G3 |
0.751 | -0.090 | -3 | 0.373 |
EPHA2 |
0.749 | -0.207 | -1 | 0.773 |
ERBB4 |
0.749 | -0.154 | 1 | 0.610 |
FES |
0.742 | -0.201 | -1 | 0.752 |
ZAP70 |
0.731 | -0.134 | -1 | 0.692 |
CK1A |
0.726 | -0.079 | -3 | 0.421 |
CK1G2 |
0.721 | -0.115 | -3 | 0.474 |