Motif 1082 (n=938)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A0JNW5	BLTP3B	T441	ochoa	Bridge-like lipid transfer protein family member 3B (Syntaxin-6 Habc-interacting protein of 164 kDa) (UHRF1-binding protein 1-like)	Tube-forming lipid transport protein which mediates the transfer of lipids between membranes at organelle contact sites (PubMed:35499567). Required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex (PubMed:20163565, PubMed:35499567). {ECO:0000269\|PubMed:20163565, ECO:0000269\|PubMed:35499567}.
A3KN83	SBNO1	T686	ochoa	Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3)	Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation. {ECO:0000250\|UniProtKB:Q689Z5}.
A4D1S0	KLRG2	T141	ochoa	Killer cell lectin-like receptor subfamily G member 2 (C-type lectin domain family 15 member B)	None
A4UGR9	XIRP2	T3045	ochoa	Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin)	Protects actin filaments from depolymerization (PubMed:15454575). Required for correct morphology of cell membranes and maturation of intercalated disks of cardiomyocytes via facilitating localization of XIRP1 and CDH2 to the termini of aligned mature cardiomyocytes (By similarity). Thereby required for correct postnatal heart development and growth regulation that is crucial for overall heart morphology and diastolic function (By similarity). Required for normal electrical conduction in the heart including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with the cardiac ion channel components Scn5a/Nav1.5 and Kcna5/Kv1.5 (By similarity). Required for regular actin filament spacing of the paracrystalline array in both inner and outer hair cells of the cochlea, thereby required for maintenance of stereocilia morphology (By similarity). {ECO:0000250\|UniProtKB:Q4U4S6, ECO:0000269\|PubMed:15454575}.
A6NEL2	SOWAHB	T760	ochoa	Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B)	None
A6NKT7	RGPD3	T1475	ochoa	RanBP2-like and GRIP domain-containing protein 3	None
A6NKT7	RGPD3	T1566	ochoa	RanBP2-like and GRIP domain-containing protein 3	None
A8MW92	PHF20L1	T224	ochoa	PHD finger protein 20-like protein 1	Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (PubMed:24492612, PubMed:29358331). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity). {ECO:0000250\|UniProtKB:Q8CCJ9, ECO:0000269\|PubMed:24492612, ECO:0000269\|PubMed:29358331}.
B2RPK0	HMGB1P1	T22	ochoa	High mobility group protein B1-like 1 (High mobility group protein 1-like 1) (HMG-1L1)	Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}.
D6RIA3	C4orf54	T733	ochoa	Uncharacterized protein C4orf54 (Familial obliterative portal venopathy)	None
O00139	KIF2A	T97	psp	Kinesin-like protein KIF2A (Kinesin-2) (hK2)	Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. {ECO:0000269\|PubMed:15843429, ECO:0000269\|PubMed:17538014, ECO:0000269\|PubMed:18411309, ECO:0000269\|PubMed:30785839}.
O00148	DDX39A	T171	ochoa	ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49)	Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269\|PubMed:15047853, ECO:0000269\|PubMed:17548965, ECO:0000269\|PubMed:32393512, ECO:0000269\|PubMed:33941617, ECO:0000269\|PubMed:37949067, ECO:0000269\|PubMed:38801080}.
O00257	CBX4	T435	ochoa	E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)	E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate (PubMed:12679040, PubMed:22825850). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). {ECO:0000269\|PubMed:12679040, ECO:0000269\|PubMed:22825850}.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). {ECO:0000250\|UniProtKB:O55187, ECO:0000269\|PubMed:12167701, ECO:0000269\|PubMed:19636380, ECO:0000269\|PubMed:21282530}.
O00401	WASL	T205	ochoa	Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)	Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742). {ECO:0000250\|UniProtKB:Q91YD9, ECO:0000269\|PubMed:16767080, ECO:0000269\|PubMed:19366662, ECO:0000269\|PubMed:19487689, ECO:0000269\|PubMed:19767742, ECO:0000269\|PubMed:22847007, ECO:0000269\|PubMed:22921828, ECO:0000269\|PubMed:9422512}.
O00443	PIK3C2A	T614	ochoa	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)	Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269\|PubMed:10766823, ECO:0000269\|PubMed:10805725, ECO:0000269\|PubMed:11239472, ECO:0000269\|PubMed:12719431, ECO:0000269\|PubMed:16215232, ECO:0000269\|PubMed:21081650, ECO:0000269\|PubMed:31034465, ECO:0000269\|PubMed:9337861}.
O00559	EBAG9	T82	ochoa	Receptor-binding cancer antigen expressed on SiSo cells (Cancer-associated surface antigen RCAS1) (Estrogen receptor-binding fragment-associated gene 9 protein)	May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. {ECO:0000269\|PubMed:12054692, ECO:0000269\|PubMed:12138241, ECO:0000269\|PubMed:12672804}.
O14638	ENPP3	T205	psp	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Dinucleoside polyphosphatase) (EC 3.6.1.-) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c)	Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535, PubMed:9344668). Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation (By similarity). Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well (PubMed:12846830). In addition, displays an alkaline phosphodiesterase activity in vitro (PubMed:11342463). {ECO:0000250\|UniProtKB:Q6DYE8, ECO:0000269\|PubMed:11342463, ECO:0000269\|PubMed:12846830, ECO:0000269\|PubMed:29717535, ECO:0000269\|PubMed:9344668}.
O14715	RGPD8	T1474	ochoa	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)	None
O14715	RGPD8	T1565	ochoa	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)	None
O14950	MYL12B	T19	ochoa\|psp	Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)	Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. {ECO:0000269\|PubMed:10965042}.
O14983	ATP2A1	T554	ochoa	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)	Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250\|UniProtKB:P04191, ECO:0000269\|PubMed:10914677}.
O15014	ZNF609	T256	ochoa	Zinc finger protein 609	Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250\|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269\|PubMed:28344082}.
O15085	ARHGEF11	T1461	ochoa	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269\|PubMed:21670212}.
O15400	STX7	T78	ochoa	Syntaxin-7	May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
O43175	PHGDH	T147	ochoa	D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37)	Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. {ECO:0000269\|PubMed:11751922, ECO:0000269\|PubMed:25406093}.
O43242	PSMD3	T48	ochoa	26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269\|PubMed:1317798}.
O43318	MAP3K7	T538	psp	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Plays an important role in the cascades of cellular responses evoked by changes in the environment (PubMed:10094049, PubMed:11460167, PubMed:12589052, PubMed:16845370, PubMed:16893890, PubMed:21512573, PubMed:8663074, PubMed:9079627). Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) (PubMed:16893890, PubMed:9079627). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 (PubMed:11460167, PubMed:8663074). These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) (PubMed:11460167, PubMed:12589052, PubMed:8663074). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex (PubMed:12589052, PubMed:8663074). Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation (PubMed:10094049, PubMed:11460167). In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (PubMed:16893890). Promotes TRIM5 capsid-specific restriction activity (PubMed:21512573). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles (PubMed:37832545). {ECO:0000250\|UniProtKB:Q62073, ECO:0000269\|PubMed:10094049, ECO:0000269\|PubMed:11460167, ECO:0000269\|PubMed:12589052, ECO:0000269\|PubMed:16845370, ECO:0000269\|PubMed:16893890, ECO:0000269\|PubMed:21512573, ECO:0000269\|PubMed:37832545, ECO:0000269\|PubMed:8663074, ECO:0000269\|PubMed:9079627}.
O43390	HNRNPR	T351	ochoa	Heterogeneous nuclear ribonucleoprotein R (hnRNP R)	Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.
O43663	PRC1	T497	ochoa	Protein regulator of cytokinesis 1	Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000269\|PubMed:12082078, ECO:0000269\|PubMed:15297875, ECO:0000269\|PubMed:15625105, ECO:0000269\|PubMed:16431929, ECO:0000269\|PubMed:17409436, ECO:0000269\|PubMed:19468300, ECO:0000269\|PubMed:20691902, ECO:0000269\|PubMed:9885575}.
O43670	ZNF207	T360	ochoa	BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207)	Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269\|PubMed:24462186, ECO:0000269\|PubMed:24462187, ECO:0000269\|PubMed:26388440}.
O43683	BUB1	T213	psp	Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)	Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269\|PubMed:10198256, ECO:0000269\|PubMed:15020684, ECO:0000269\|PubMed:15525512, ECO:0000269\|PubMed:15723797, ECO:0000269\|PubMed:16760428, ECO:0000269\|PubMed:17158872, ECO:0000269\|PubMed:19487456, ECO:0000269\|PubMed:20739936, ECO:0000269\|PubMed:35044816}.
O43683	BUB1	T441	ochoa	Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A)	Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. {ECO:0000269\|PubMed:10198256, ECO:0000269\|PubMed:15020684, ECO:0000269\|PubMed:15525512, ECO:0000269\|PubMed:15723797, ECO:0000269\|PubMed:16760428, ECO:0000269\|PubMed:17158872, ECO:0000269\|PubMed:19487456, ECO:0000269\|PubMed:20739936, ECO:0000269\|PubMed:35044816}.
O43707	ACTN4	T249	ochoa	Alpha-actinin-4 (Non-muscle alpha-actinin 4)	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250\|UniProtKB:P57780, ECO:0000269\|PubMed:15772161, ECO:0000269\|PubMed:22351778, ECO:0000269\|PubMed:22689882, ECO:0000305\|PubMed:9508771}.
O60271	SPAG9	T365	ochoa	C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250\|UniProtKB:Q58A65, ECO:0000269\|PubMed:14743216, ECO:0000269\|PubMed:29146937}.
O60292	SIPA1L3	T296	ochoa	Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)	Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269\|PubMed:26231217}.
O60318	MCM3AP	T530	ochoa	Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase)	[Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:20005110, PubMed:20384790, PubMed:22307388, PubMed:23591820). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269\|PubMed:20005110, ECO:0000269\|PubMed:20384790, ECO:0000269\|PubMed:22307388, ECO:0000269\|PubMed:23591820, ECO:0000269\|PubMed:23652018}.; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (PubMed:11258703, PubMed:12226073). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations (PubMed:23652018). {ECO:0000269\|PubMed:11258703, ECO:0000269\|PubMed:12226073, ECO:0000269\|PubMed:23652018}.
O60506	SYNCRIP	T348	ochoa	Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)	Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. {ECO:0000269\|PubMed:11051545, ECO:0000269\|PubMed:11134005, ECO:0000269\|PubMed:11352648, ECO:0000269\|PubMed:11574476, ECO:0000269\|PubMed:19029303, ECO:0000269\|PubMed:23071094}.
O60673	REV3L	T1447	ochoa	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)	Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269\|PubMed:24449906}.
O60716	CTNND1	T643	ochoa	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269\|PubMed:10207085, ECO:0000269\|PubMed:14610055, ECO:0000269\|PubMed:17344476, ECO:0000269\|PubMed:18343367, ECO:0000269\|PubMed:20371349}.
O60779	SLC19A2	T241	ochoa	Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)	High-affinity transporter for the intake of thiamine (PubMed:10391222, PubMed:10542220, PubMed:21836059, PubMed:33008889, PubMed:35512554, PubMed:35724964). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964). {ECO:0000269\|PubMed:10391222, ECO:0000269\|PubMed:10542220, ECO:0000269\|PubMed:21836059, ECO:0000269\|PubMed:33008889, ECO:0000269\|PubMed:35512554, ECO:0000269\|PubMed:35724964}.
O60814	H2BC12	Y38	ochoa	Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
O75110	ATP9A	T377	ochoa	Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A)	Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation (PubMed:27733620, PubMed:30213940, PubMed:36604604). Also involved in endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940). In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940). Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313). The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313). Required for the maintenance of neurite morphology and synaptic transmission (By similarity). {ECO:0000250\|UniProtKB:O70228, ECO:0000269\|PubMed:27733620, ECO:0000269\|PubMed:30213940, ECO:0000269\|PubMed:30947313, ECO:0000269\|PubMed:36604604}.
O75116	ROCK2	T1032	ochoa	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269\|PubMed:10579722, ECO:0000269\|PubMed:15699075, ECO:0000269\|PubMed:16574662, ECO:0000269\|PubMed:17015463, ECO:0000269\|PubMed:19131646, ECO:0000269\|PubMed:19997641, ECO:0000269\|PubMed:21084279, ECO:0000269\|PubMed:21147781}.
O75116	ROCK2	T1214	ochoa	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269\|PubMed:10579722, ECO:0000269\|PubMed:15699075, ECO:0000269\|PubMed:16574662, ECO:0000269\|PubMed:17015463, ECO:0000269\|PubMed:19131646, ECO:0000269\|PubMed:19997641, ECO:0000269\|PubMed:21084279, ECO:0000269\|PubMed:21147781}.
O75150	RNF40	T557	ochoa	E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269\|PubMed:16307923, ECO:0000269\|PubMed:19410543}.; FUNCTION: (Microbial infection) Promotes the human herpesvirus 8 (KSHV) lytic cycle by inducing the expression of lytic viral genes including the latency switch gene RTA/ORF50. {ECO:0000269\|PubMed:37888983}.
O75167	PHACTR2	T20	ochoa	Phosphatase and actin regulator 2	None
O75334	PPFIA2	T264	ochoa	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)	Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines (PubMed:30021165). {ECO:0000269\|PubMed:30021165, ECO:0000269\|PubMed:9624153}.
O75363	BCAS1	T441	ochoa	Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1)	Required for myelination. {ECO:0000250\|UniProtKB:Q80YN3}.
O75410	TACC1	T250	ochoa	Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)	Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269\|PubMed:20078863}.
O75436	VPS26A	T307	ochoa	Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26)	Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250\|UniProtKB:P40336, ECO:0000269\|PubMed:15078902, ECO:0000269\|PubMed:15078903, ECO:0000269\|PubMed:15247922, ECO:0000269\|PubMed:16407403, ECO:0000269\|PubMed:22070227, ECO:0000269\|PubMed:22279231, ECO:0000303\|PubMed:20923837, ECO:0000303\|PubMed:21602791, ECO:0000303\|PubMed:21725319, ECO:0000303\|PubMed:23563491, ECO:0000305}.
O75449	KATNA1	T81	ochoa	Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin)	Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255\|HAMAP-Rule:MF_03023, ECO:0000269\|PubMed:10751153, ECO:0000269\|PubMed:11870226, ECO:0000269\|PubMed:19287380}.
O75475	PSIP1	T99	ochoa	PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)	Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. {ECO:0000269\|PubMed:15642333}.
O75676	RPS6KA4	T542	ochoa	Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. {ECO:0000269\|PubMed:11035004, ECO:0000269\|PubMed:12773393, ECO:0000269\|PubMed:9792677}.
O75781	PALM	T141	ochoa	Paralemmin-1 (Paralemmin)	Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269\|PubMed:14978216}.
O76021	RSL1D1	T415	ochoa	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269\|PubMed:18678645, ECO:0000269\|PubMed:22419112}.
O76070	SNCG	T44	ochoa	Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR)	Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}.
O94823	ATP10B	T982	ochoa	Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B)	Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons. {ECO:0000269\|PubMed:32172343}.
O94874	UFL1	T412	ochoa	E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1)	E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498, PubMed:27351204, PubMed:30626644, PubMed:30783677, PubMed:32160526, PubMed:32807901, PubMed:35394863, PubMed:36121123, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37311461, PubMed:37595036, PubMed:37795761, PubMed:38377992, PubMed:38383785, PubMed:38383789). Catalyzes ufmylation of many protein, such as CD274/PD-L1, CDK5RAP3, CYB5R3, DDRGK1, EIF6, histone H4, MRE11, P4HB, PDCD1/PD-1, TRIP4, RPN1, RPS20/uS10, RPL10/uL16, RPL26/uL24, SYVN1/HRD1 and TP53/p53 (PubMed:20018847, PubMed:20531390, PubMed:25219498, PubMed:30783677, PubMed:30886146, PubMed:32160526, PubMed:35753586, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37595036, PubMed:37795761, PubMed:38383785, PubMed:38383789). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (PubMed:38383785, PubMed:38383789). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (PubMed:37036982, PubMed:37595036, PubMed:38383785, PubMed:38383789). Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins (PubMed:23152784, PubMed:32160526, PubMed:36543799). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:32050156). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is, a collateral effect or is required for ufmylation (PubMed:20018847, PubMed:20531390). Acts as a negative regulator of T-cell activation by mediating ufmylation and stabilization of PDCD1/PD-1 (PubMed:38377992). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 and ufmylation of MRE11 (PubMed:30783677, PubMed:30886146). Mediates ufmylation of TP53/p53, promoting its stability (PubMed:32807901). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (PubMed:25219498). Required for hematopoietic stem cell function and hematopoiesis (By similarity). {ECO:0000250\|UniProtKB:Q8CCJ3, ECO:0000269\|PubMed:20018847, ECO:0000269\|PubMed:20164180, ECO:0000269\|PubMed:20228063, ECO:0000269\|PubMed:20531390, ECO:0000269\|PubMed:23152784, ECO:0000269\|PubMed:25219498, ECO:0000269\|PubMed:27351204, ECO:0000269\|PubMed:30626644, ECO:0000269\|PubMed:30783677, ECO:0000269\|PubMed:30886146, ECO:0000269\|PubMed:32050156, ECO:0000269\|PubMed:32160526, ECO:0000269\|PubMed:32807901, ECO:0000269\|PubMed:35394863, ECO:0000269\|PubMed:35753586, ECO:0000269\|PubMed:36121123, ECO:0000269\|PubMed:36543799, ECO:0000269\|PubMed:36893266, ECO:0000269\|PubMed:37036982, ECO:0000269\|PubMed:37311461, ECO:0000269\|PubMed:37595036, ECO:0000269\|PubMed:37795761, ECO:0000269\|PubMed:38377992, ECO:0000269\|PubMed:38383785, ECO:0000269\|PubMed:38383789}.
O94916	NFAT5	T241	ochoa	Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP)	Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269\|PubMed:10051678, ECO:0000269\|PubMed:10377394, ECO:0000269\|PubMed:22266867, ECO:0000269\|PubMed:34049076}.
O94921	CDK14	T79	ochoa	Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)	Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269\|PubMed:16461467, ECO:0000269\|PubMed:17517622, ECO:0000269\|PubMed:19524571, ECO:0000269\|PubMed:20059949}.
O94953	KDM4B	T1069	ochoa	Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B)	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250\|UniProtKB:Q91VY5, ECO:0000269\|PubMed:16603238, ECO:0000269\|PubMed:28262558}.
O94967	WDR47	T423	ochoa	WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin)	None
O94986	CEP152	T1351	ochoa	Centrosomal protein of 152 kDa (Cep152)	Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250\|UniProtKB:A2AUM9, ECO:0000250\|UniProtKB:Q498G2, ECO:0000269\|PubMed:20852615, ECO:0000269\|PubMed:21059844, ECO:0000269\|PubMed:21131973}.
O95071	UBR5	T1969	ochoa	E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)	E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubiquitinated substrates (PubMed:29033132, PubMed:37409633). Component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Recognizes type-1 N-degrons, containing positively charged amino acids (Arg, Lys and His) (By similarity). Together with UBR4, part of a cytoplasm protein quality control pathway that prevents protein aggregation by catalyzing assembly of heterotypic 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on aggregated proteins, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome: UBR5 is probably branching multiple 'Lys-48'-linked chains of substrates initially modified with mixed conjugates by UBR4 (PubMed:29033132). Together with ITCH, catalyzes 'Lys-48'-/'Lys-63'-branched ubiquitination of TXNIP, leading to its degradation: UBR5 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by ITCH (PubMed:29378950). Catalytic component of a nuclear protein quality control pathway that mediates ubiquitination and degradation of unpaired transcription factors (i.e. transcription factors that are not assembled into functional multiprotein complexes): specifically recognizes and binds degrons that are not accessible when transcription regulators are associated with their coactivators (PubMed:37478846, PubMed:37478862). Ubiquitinates various unpaired transcription regulator (MYC, SUPT4H1, SUPT5H, CDC20 and MCRS1), as well as ligand-bound nuclear receptors (ESR1, NR1H3, NR3C1, PGR, RARA, RXRA AND VDR) that are not associated with their nuclear receptor coactivators (NCOAs) (PubMed:33208877, PubMed:37478846, PubMed:37478862). Involved in maturation and/or transcriptional regulation of mRNA by mediating polyubiquitination and activation of CDK9 (PubMed:21127351). Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (PubMed:22884692). Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response (PubMed:11714696). Ubiquitinates acetylated PCK1 (PubMed:21726808). Acts as a positive regulator of the canonical Wnt signaling pathway by mediating (1) ubiquitination and stabilization of CTNNB1, and (2) 'Lys-48'-linked ubiquitination and degradation of TLE3 (PubMed:21118991, PubMed:28689657). Promotes disassembly of the mitotic checkpoint complex (MCC) from the APC/C complex by catalyzing ubiquitination of BUB1B, BUB3 and CDC20 (PubMed:35217622). Plays an essential role in extraembryonic development (By similarity). Required for the maintenance of skeletal tissue homeostasis by acting as an inhibitor of hedgehog (HH) signaling (By similarity). {ECO:0000250\|UniProtKB:Q80TP3, ECO:0000269\|PubMed:11714696, ECO:0000269\|PubMed:21118991, ECO:0000269\|PubMed:21127351, ECO:0000269\|PubMed:21726808, ECO:0000269\|PubMed:22884692, ECO:0000269\|PubMed:28689657, ECO:0000269\|PubMed:29033132, ECO:0000269\|PubMed:29378950, ECO:0000269\|PubMed:33208877, ECO:0000269\|PubMed:35217622, ECO:0000269\|PubMed:37409633, ECO:0000269\|PubMed:37478846, ECO:0000269\|PubMed:37478862}.
O95159	ZFPL1	T223	ochoa	Zinc finger protein-like 1 (Zinc finger protein MCG4)	Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130. {ECO:0000269\|PubMed:18323775}.
O95197	RTN3	T396	ochoa	Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)	May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269\|PubMed:15286784, ECO:0000269\|PubMed:16054885, ECO:0000269\|PubMed:17031492, ECO:0000269\|PubMed:17191123, ECO:0000269\|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269\|PubMed:17182608}.
O95208	EPN2	T332	ochoa	Epsin-2 (EPS-15-interacting protein 2)	Plays a role in the formation of clathrin-coated invaginations and endocytosis. {ECO:0000269\|PubMed:10567358}.
O95425	SVIL	T907	ochoa	Supervillin (Archvillin) (p205/p250)	[Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269\|PubMed:12711699, ECO:0000269\|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250\|UniProtKB:O46385}.
O95684	CEP43	T169	ochoa	Centrosomal protein 43 (FGFR1 oncogene partner)	Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269\|PubMed:16314388, ECO:0000269\|PubMed:28625565, ECO:0000269\|PubMed:28659385}.
O95786	RIGI	T667	psp	Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)	Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:24366338, PubMed:28469175, PubMed:29117565, PubMed:31006531, PubMed:34935440, PubMed:35263596, PubMed:36793726). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169). Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.74). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269\|PubMed:15208624, ECO:0000269\|PubMed:15708988, ECO:0000269\|PubMed:16125763, ECO:0000269\|PubMed:16127453, ECO:0000269\|PubMed:16153868, ECO:0000269\|PubMed:17190814, ECO:0000269\|PubMed:18636086, ECO:0000269\|PubMed:19122199, ECO:0000269\|PubMed:19211564, ECO:0000269\|PubMed:19576794, ECO:0000269\|PubMed:19609254, ECO:0000269\|PubMed:19631370, ECO:0000269\|PubMed:21742966, ECO:0000269\|PubMed:24366338, ECO:0000269\|PubMed:28469175, ECO:0000269\|PubMed:29117565, ECO:0000269\|PubMed:31006531, ECO:0000269\|PubMed:34935440, ECO:0000269\|PubMed:35263596, ECO:0000269\|PubMed:36793726, ECO:0000269\|Ref.74, ECO:0000303\|PubMed:21616437, ECO:0000303\|PubMed:21884169}.
O95810	CAVIN2	T296	ochoa	Caveolae-associated protein 2 (Cavin-2) (PS-p68) (Phosphatidylserine-binding protein) (Serum deprivation-response protein)	Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250\|UniProtKB:Q66H98, ECO:0000269\|PubMed:19525939}.
P00367	GLUD1	T409	ochoa	Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)	Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250\|UniProtKB:P10860, ECO:0000269\|PubMed:11032875, ECO:0000269\|PubMed:11254391, ECO:0000269\|PubMed:11297618, ECO:0000269\|PubMed:16023112, ECO:0000269\|PubMed:16959573, ECO:0000269\|PubMed:9571255}.
P00488	F13A1	T689	ochoa	Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain)	Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. {ECO:0000269\|PubMed:27363989}.
P04004	VTN	T69	psp	Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B]	Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.; FUNCTION: Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
P04406	GAPDH	T229	ochoa\|psp	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)	Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250\|UniProtKB:P04797, ECO:0000269\|PubMed:11724794, ECO:0000269\|PubMed:23071094, ECO:0000269\|PubMed:23332158, ECO:0000269\|PubMed:27387501, ECO:0000269\|PubMed:3170585}.
P04406	GAPDH	T237	ochoa\|psp	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)	Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250\|UniProtKB:P04797, ECO:0000269\|PubMed:11724794, ECO:0000269\|PubMed:23071094, ECO:0000269\|PubMed:23332158, ECO:0000269\|PubMed:27387501, ECO:0000269\|PubMed:3170585}.
P04626	ERBB2	T686	psp	Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.
P05181	CYP2E1	T432	psp	Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J)	A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768). May be involved in the oxidative metabolism of xenobiotics (Probable). {ECO:0000269\|PubMed:10553002, ECO:0000269\|PubMed:18577768, ECO:0000305\|PubMed:9348445}.
P05388	RPLP0	T144	ochoa	Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E)	Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
P05455	SSB	T362	ochoa	Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)	Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269\|PubMed:12384597, ECO:0000269\|PubMed:2470590, ECO:0000269\|PubMed:3192525}.
P05771	PRKCB	T48	ochoa	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250\|UniProtKB:P68404, ECO:0000269\|PubMed:11598012, ECO:0000269\|PubMed:19176525, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:25313067, ECO:0000269\|PubMed:25982116, ECO:0000269\|PubMed:36040231}.
P05771	PRKCB	T113	ochoa	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250\|UniProtKB:P68404, ECO:0000269\|PubMed:11598012, ECO:0000269\|PubMed:19176525, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:25313067, ECO:0000269\|PubMed:25982116, ECO:0000269\|PubMed:36040231}.
P05771	PRKCB	T314	ochoa	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250\|UniProtKB:P68404, ECO:0000269\|PubMed:11598012, ECO:0000269\|PubMed:19176525, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:25313067, ECO:0000269\|PubMed:25982116, ECO:0000269\|PubMed:36040231}.
P05771	PRKCB	T642	ochoa\|psp	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250\|UniProtKB:P68404, ECO:0000269\|PubMed:11598012, ECO:0000269\|PubMed:19176525, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:25313067, ECO:0000269\|PubMed:25982116, ECO:0000269\|PubMed:36040231}.
P06400	RB1	T625	ochoa	Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)	Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {ECO:0000250\|UniProtKB:P13405, ECO:0000250\|UniProtKB:P33568, ECO:0000269\|PubMed:10499802, ECO:0000269\|PubMed:15084261}.; FUNCTION: (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {ECO:0000269\|PubMed:1316611, ECO:0000269\|PubMed:17974914, ECO:0000269\|PubMed:18701596, ECO:0000269\|PubMed:2839300, ECO:0000269\|PubMed:8892909}.
P06732	CKM	T166	ochoa	Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK)	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250\|UniProtKB:P00563}.
P06744	GPI	T251	ochoa	Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36)	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:11004567, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:11004567, PubMed:3352745). {ECO:0000269\|PubMed:11004567, ECO:0000269\|PubMed:11437381, ECO:0000269\|PubMed:28803808, ECO:0000269\|PubMed:3352745}.
P06748	NPM1	T199	ochoa\|psp	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)	Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity). {ECO:0000250\|UniProtKB:Q61937, ECO:0000269\|PubMed:12882984, ECO:0000269\|PubMed:16107701, ECO:0000269\|PubMed:17015463, ECO:0000269\|PubMed:18809582, ECO:0000269\|PubMed:19188445, ECO:0000269\|PubMed:20352051, ECO:0000269\|PubMed:21084279, ECO:0000269\|PubMed:22002061, ECO:0000269\|PubMed:22528486, ECO:0000269\|PubMed:25956029}.
P07195	LDHB	T87	ochoa	L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)	Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269\|PubMed:27618187}.
P07954	FH	T90	ochoa\|psp	Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2)	Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:30761759). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). {ECO:0000269\|PubMed:30761759, ECO:0000305}.; FUNCTION: [Isoform Mitochondrial]: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. {ECO:0000250\|UniProtKB:P10173}.; FUNCTION: [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate (By similarity). Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed:20231875, PubMed:26237645). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2) (PubMed:26237645). {ECO:0000250\|UniProtKB:P97807, ECO:0000269\|PubMed:20231875, ECO:0000269\|PubMed:26237645}.
P08133	ANXA6	T309	ochoa	Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70)	May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
P09429	HMGB1	T22	ochoa	High mobility group protein B1 (High mobility group protein 1) (HMG-1)	Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability (PubMed:33147444). Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as a danger-associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors (PubMed:34743181). In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23446148, PubMed:23519706, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). {ECO:0000250\|UniProtKB:P10103, ECO:0000250\|UniProtKB:P12682, ECO:0000250\|UniProtKB:P63158, ECO:0000250\|UniProtKB:P63159, ECO:0000269\|PubMed:23303669, ECO:0000269\|PubMed:25549101, ECO:0000269\|PubMed:27362237, ECO:0000269\|PubMed:33147444, ECO:0000269\|PubMed:34743181, ECO:0000305\|PubMed:23446148, ECO:0000305\|PubMed:23519706, ECO:0000305\|PubMed:23994764, ECO:0000305\|PubMed:25048472}.; FUNCTION: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:20123072). May have an enhancing role in nucleotide excision repair (NER) (By similarity). However, effects in NER using in vitro systems have been reported conflictingly (PubMed:19360789, PubMed:19446504). May be involved in mismatch repair (MMR) and base excision repair (BER) pathways (PubMed:15014079, PubMed:16143102, PubMed:17803946). May be involved in double strand break repair such as non-homologous end joining (NHEJ) (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding (By similarity). Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities (By similarity). Facilitates binding of TP53 to DNA (PubMed:23063560). Proposed to be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1; however, this function has been questioned (By similarity). Can modulate the activity of the telomerase complex and may be involved in telomere maintenance (By similarity). {ECO:0000250\|UniProtKB:P10103, ECO:0000250\|UniProtKB:P63158, ECO:0000250\|UniProtKB:P63159, ECO:0000269\|PubMed:15014079, ECO:0000269\|PubMed:16143102, ECO:0000269\|PubMed:17803946, ECO:0000269\|PubMed:19446504, ECO:0000269\|PubMed:23063560, ECO:0000305\|PubMed:19360789, ECO:0000305\|PubMed:20123072}.; FUNCTION: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation (PubMed:20819940). Involved in oxidative stress-mediated autophagy (PubMed:21395369). Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury (By similarity). In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy (By similarity). Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages (By similarity). {ECO:0000250\|UniProtKB:P63158, ECO:0000269\|PubMed:20819940, ECO:0000269\|PubMed:21395369}.; FUNCTION: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization (PubMed:22370717). Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM (By similarity). Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE (PubMed:24971542). Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, PubMed:18354232, PubMed:19264983, PubMed:20547845, PubMed:24474694). Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12 (PubMed:15607795). TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2 (PubMed:20547845). In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes (PubMed:18354232, PubMed:21660935, PubMed:25660311). Contributes to tumor proliferation by association with ACER/RAGE (By similarity). Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism (By similarity). Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells (By similarity). In adaptive immunity may be involved in enhancing immunity through activation of effector T cells and suppression of regulatory T (TReg) cells (PubMed:15944249, PubMed:22473704). In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression (By similarity). Also reported to limit proliferation of T-cells (By similarity). Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production (PubMed:19064698). Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106 (PubMed:18631454). During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes (By similarity). {ECO:0000250\|UniProtKB:P10103, ECO:0000250\|UniProtKB:P63158, ECO:0000250\|UniProtKB:P63159, ECO:0000269\|PubMed:12765338, ECO:0000269\|PubMed:15607795, ECO:0000269\|PubMed:15944249, ECO:0000269\|PubMed:18250463, ECO:0000269\|PubMed:18354232, ECO:0000269\|PubMed:18631454, ECO:0000269\|PubMed:19064698, ECO:0000269\|PubMed:19264983, ECO:0000269\|PubMed:20547845, ECO:0000269\|PubMed:21660935, ECO:0000269\|PubMed:22370717, ECO:0000269\|PubMed:22473704, ECO:0000269\|PubMed:24474694, ECO:0000269\|PubMed:24971542, ECO:0000269\|PubMed:25660311, ECO:0000269\|Ref.8}.; FUNCTION: (Microbial infection) Critical for entry of human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63 (PubMed:33147444). Regulates the expression of the pro-viral genes ACE2 and CTSL through chromatin modulation (PubMed:33147444). Required for SARS-CoV-2 ORF3A-induced reticulophagy which induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449). {ECO:0000269\|PubMed:33147444, ECO:0000269\|PubMed:35239449}.; FUNCTION: (Microbial infection) Associates with the influenza A viral protein NP in the nucleus of infected cells, promoting viral growth and enhancing the activity of the viral polymerase. {ECO:0000269\|PubMed:22696656}.; FUNCTION: (Microbial infection) Promotes Epstein-Barr virus (EBV) latent-to-lytic switch by sustaining the expression of the viral transcription factor BZLF1 that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle. Mechanistically, participates in EBV reactivation through the NLRP3 inflammasome. {ECO:0000269\|PubMed:34922257}.; FUNCTION: (Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome. In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex. {ECO:0000269\|PubMed:34971702}.
P09661	SNRPA1	T189	ochoa	U2 small nuclear ribonucleoprotein A' (U2 snRNP A')	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:27035939, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:28781166, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:9716128}.
P09874	PARP1	T361	ochoa	Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]	Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250\|UniProtKB:P11103, ECO:0000269\|PubMed:15607977, ECO:0000269\|PubMed:17177976, ECO:0000269\|PubMed:17396150, ECO:0000269\|PubMed:18055453, ECO:0000269\|PubMed:18172500, ECO:0000269\|PubMed:19344625, ECO:0000269\|PubMed:19661379, ECO:0000269\|PubMed:19764761, ECO:0000269\|PubMed:20388712, ECO:0000269\|PubMed:21680843, ECO:0000269\|PubMed:22464733, ECO:0000269\|PubMed:22582261, ECO:0000269\|PubMed:23230272, ECO:0000269\|PubMed:24906880, ECO:0000269\|PubMed:25043379, ECO:0000269\|PubMed:26344098, ECO:0000269\|PubMed:26626479, ECO:0000269\|PubMed:26626480, ECO:0000269\|PubMed:27067600, ECO:0000269\|PubMed:27256882, ECO:0000269\|PubMed:27257257, ECO:0000269\|PubMed:27471034, ECO:0000269\|PubMed:28190768, ECO:0000269\|PubMed:29954836, ECO:0000269\|PubMed:30104678, ECO:0000269\|PubMed:30257210, ECO:0000269\|PubMed:30356214, ECO:0000269\|PubMed:31796734, ECO:0000269\|PubMed:32028527, ECO:0000269\|PubMed:32241924, ECO:0000269\|PubMed:32315358, ECO:0000269\|PubMed:32358582, ECO:0000269\|PubMed:32844745, ECO:0000269\|PubMed:33186521, ECO:0000269\|PubMed:33412112, ECO:0000269\|PubMed:33589610, ECO:0000269\|PubMed:33683197, ECO:0000269\|PubMed:34049076, ECO:0000269\|PubMed:34465625, ECO:0000269\|PubMed:34625544, ECO:0000269\|PubMed:34732825, ECO:0000269\|PubMed:34737271, ECO:0000269\|PubMed:34795260, ECO:0000269\|PubMed:34874266, ECO:0000269\|PubMed:35124853, ECO:0000269\|PubMed:35393539, ECO:0000269\|PubMed:35460603, ECO:0000269\|PubMed:7852410, ECO:0000269\|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269\|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269\|PubMed:35104452}.
P0DJD0	RGPD1	T1459	ochoa	RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)	None
P0DJD1	RGPD2	T1467	ochoa	RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2)	None
P0DKX0	ZNF728	T138	ochoa	Zinc finger protein 728	None
P0DMV8	HSPA1A	T66	psp	Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250\|UniProtKB:P0DMW0, ECO:0000269\|PubMed:22528486, ECO:0000269\|PubMed:23973223, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:27137183, ECO:0000269\|PubMed:27708256, ECO:0000269\|PubMed:28842558, ECO:0000269\|PubMed:9499401, ECO:0000303\|PubMed:24012426, ECO:0000303\|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269\|PubMed:16537599}.
P10074	ZBTB48	T295	ochoa	Zinc finger and BTB domain-containing protein 48 (Krueppel-related zinc finger protein 3) (hKR3) (Telomere zinc finger-associated protein) (TZAP) (Telomere-binding protein and transcriptional activator ZBTB48) (Zinc finger protein 855)	Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length (PubMed:28082411, PubMed:28500257). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28082411, PubMed:28500257). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:24382891, PubMed:28500257, PubMed:7969177). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression (PubMed:39562739). In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs (PubMed:39300486). {ECO:0000269\|PubMed:24382891, ECO:0000269\|PubMed:28082411, ECO:0000269\|PubMed:28500257, ECO:0000269\|PubMed:39300486, ECO:0000269\|PubMed:39562739, ECO:0000269\|PubMed:7969177}.
P10243	MYBL1	T541	ochoa	Myb-related protein A (A-Myb) (Myb-like protein 1)	Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7987850, PubMed:8058310). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity). {ECO:0000250\|UniProtKB:P51960, ECO:0000269\|PubMed:7987850, ECO:0000269\|PubMed:8058310}.
P10275	AR	T649	ochoa	Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)	Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269\|PubMed:14664718, ECO:0000269\|PubMed:15563469, ECO:0000269\|PubMed:17591767, ECO:0000269\|PubMed:17911242, ECO:0000269\|PubMed:18084323, ECO:0000269\|PubMed:19022849, ECO:0000269\|PubMed:19345326, ECO:0000269\|PubMed:20812024, ECO:0000269\|PubMed:20980437, ECO:0000269\|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269\|PubMed:19244107}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269\|PubMed:19244107}.
P10412	H1-4	T146	ochoa\|psp	Histone H1.4 (Histone H1b) (Histone H1s-4)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P11308	ERG	T180	psp	Transcriptional regulator ERG (Transforming protein ERG)	Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
P11532	DMD	T3361	ochoa\|psp	Dystrophin	Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250\|UniProtKB:P11531, ECO:0000269\|PubMed:16710609}.
P12814	ACTN1	T230	ochoa	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269\|PubMed:22689882}.
P12882	MYH1	T69	ochoa	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250\|UniProtKB:Q5SX40}.
P12883	MYH7	T60	ochoa	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305\|PubMed:26150528, ECO:0000305\|PubMed:26246073}.
P12883	MYH7	T68	ochoa	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305\|PubMed:26150528, ECO:0000305\|PubMed:26246073}.
P12883	MYH7	T1513	ochoa	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305\|PubMed:26150528, ECO:0000305\|PubMed:26246073}.
P13637	ATP1A3	T475	ochoa	Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. {ECO:0000269\|PubMed:33880529}.
P13796	LCP1	T106	ochoa	Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)	Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269\|PubMed:16636079, ECO:0000269\|PubMed:17294403, ECO:0000269\|PubMed:28493397}.
P14598	NCF1	T153	psp	Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)	Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:2547247, PubMed:2550933, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (PubMed:12732142, PubMed:19801500). {ECO:0000269\|PubMed:12732142, ECO:0000269\|PubMed:19801500, ECO:0000269\|PubMed:2547247, ECO:0000269\|PubMed:2550933, ECO:0000269\|PubMed:38355798}.
P15121	AKR1B1	T245	ochoa	Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR)	Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684). {ECO:0000269\|PubMed:12732097, ECO:0000269\|PubMed:17381426, ECO:0000269\|PubMed:19010934, ECO:0000269\|PubMed:1936586, ECO:0000269\|PubMed:21329684, ECO:0000269\|PubMed:8343525}.
P15336	ATF2	T116	ochoa\|psp	Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)	Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269\|PubMed:10821277, ECO:0000269\|PubMed:15916964, ECO:0000269\|PubMed:18397884, ECO:0000269\|PubMed:22304920}.
P16144	ITGB4	T795	ochoa	Integrin beta-4 (GP150) (CD antigen CD104)	Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:19403692, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:22351760, ECO:0000269\|PubMed:28873464}.
P16157	ANK1	T1378	ochoa	Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)	Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269\|PubMed:12456646, ECO:0000269\|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269\|PubMed:12527750}.
P16402	H1-3	T147	ochoa	Histone H1.3 (Histone H1c) (Histone H1s-2)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403	H1-2	T31	ochoa	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P16403	H1-2	T146	ochoa\|psp	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
P17066	HSPA6	T68	ochoa	Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303\|PubMed:26865365}.
P17252	PRKCA	T48	ochoa	Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250\|UniProtKB:P20444, ECO:0000269\|PubMed:10848585, ECO:0000269\|PubMed:11909826, ECO:0000269\|PubMed:12724315, ECO:0000269\|PubMed:12832403, ECO:0000269\|PubMed:15016832, ECO:0000269\|PubMed:15504744, ECO:0000269\|PubMed:15526160, ECO:0000269\|PubMed:18056764, ECO:0000269\|PubMed:19176525, ECO:0000269\|PubMed:21576361, ECO:0000269\|PubMed:21806543, ECO:0000269\|PubMed:23990668, ECO:0000269\|PubMed:25313067, ECO:0000269\|PubMed:28028151, ECO:0000269\|PubMed:36040231, ECO:0000269\|PubMed:9738012, ECO:0000269\|PubMed:9830023, ECO:0000269\|PubMed:9873035, ECO:0000269\|PubMed:9927633}.
P17252	PRKCA	T638	ochoa\|psp	Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250\|UniProtKB:P20444, ECO:0000269\|PubMed:10848585, ECO:0000269\|PubMed:11909826, ECO:0000269\|PubMed:12724315, ECO:0000269\|PubMed:12832403, ECO:0000269\|PubMed:15016832, ECO:0000269\|PubMed:15504744, ECO:0000269\|PubMed:15526160, ECO:0000269\|PubMed:18056764, ECO:0000269\|PubMed:19176525, ECO:0000269\|PubMed:21576361, ECO:0000269\|PubMed:21806543, ECO:0000269\|PubMed:23990668, ECO:0000269\|PubMed:25313067, ECO:0000269\|PubMed:28028151, ECO:0000269\|PubMed:36040231, ECO:0000269\|PubMed:9738012, ECO:0000269\|PubMed:9830023, ECO:0000269\|PubMed:9873035, ECO:0000269\|PubMed:9927633}.
P17480	UBTF	T208	ochoa	Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1)	Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269\|PubMed:11250903, ECO:0000269\|PubMed:11283244, ECO:0000269\|PubMed:16858408, ECO:0000269\|PubMed:28777933, ECO:0000269\|PubMed:7982918}.
P17540	CKMT2	T69	ochoa	Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK)	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
P17655	CAPN2	T370	psp	Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250\|UniProtKB:O08529, ECO:0000269\|PubMed:17650508}.
P18754	RCC1	T32	ochoa\|psp	Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)	Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis (PubMed:11336674, PubMed:17435751, PubMed:1944575, PubMed:20668449, PubMed:22215983, PubMed:29042532). Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import (PubMed:22215983). Involved in the regulation of onset of chromosome condensation in the S phase (PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580). {ECO:0000269\|PubMed:11336674, ECO:0000269\|PubMed:12194828, ECO:0000269\|PubMed:17435751, ECO:0000269\|PubMed:18762580, ECO:0000269\|PubMed:1944575, ECO:0000269\|PubMed:20668449, ECO:0000269\|PubMed:22215983, ECO:0000269\|PubMed:29042532, ECO:0000269\|PubMed:3678831}.
P19338	NCL	T106	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T587	ochoa	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P20265	POU3F2	T418	ochoa	POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7)	Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). {ECO:0000250\|UniProtKB:P31360, ECO:0000250\|UniProtKB:P56222}.
P21291	CSRP1	T101	ochoa	Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1) (Epididymis luminal protein 141) (HEL-141)	Could play a role in neuronal development.
P21333	FLNA	T341	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21333	FLNA	T1603	ochoa	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250\|UniProtKB:Q8BTM8, ECO:0000269\|PubMed:22121117, ECO:0000269\|PubMed:25358863}.
P21796	VDAC1	T211	ochoa	Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (hVDAC1)	Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:30061676, PubMed:8420959). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (PubMed:10661876, PubMed:11845315, PubMed:18755977, PubMed:8420959). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:10661876, PubMed:18755977, PubMed:8420959). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:18755977, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:18755977, PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (PubMed:20230784). {ECO:0000250\|UniProtKB:Q60932, ECO:0000269\|PubMed:10661876, ECO:0000269\|PubMed:11845315, ECO:0000269\|PubMed:15033708, ECO:0000269\|PubMed:18755977, ECO:0000269\|PubMed:20230784, ECO:0000269\|PubMed:25296756, ECO:0000269\|PubMed:30061676, ECO:0000269\|PubMed:31015432, ECO:0000269\|PubMed:32047033, ECO:0000269\|PubMed:8420959}.; FUNCTION: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. {ECO:0000269\|PubMed:38065946}.
P21817	RYR1	T2848	ochoa	Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)	Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667, PubMed:18268335, PubMed:18650434, PubMed:26115329). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). {ECO:0000250\|UniProtKB:E9PZQ0, ECO:0000269\|PubMed:18268335, ECO:0000269\|PubMed:18650434, ECO:0000269\|PubMed:26115329, ECO:0000305\|PubMed:11741831, ECO:0000305\|PubMed:16163667}.
P22314	UBA1	T603	ochoa	Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269\|PubMed:1447181, ECO:0000269\|PubMed:1606621, ECO:0000269\|PubMed:22456334, ECO:0000269\|PubMed:33108101}.
P22413	ENPP1	T256	ochoa	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Alkaline phosphodiesterase I) (EC 3.1.4.1) (Membrane component chromosome 6 surface marker 1) (Nucleotide diphosphatase) (Nucleotide pyrophosphatase) (NPPase) (EC 3.6.1.9) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]	Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:25344812, PubMed:27467858, PubMed:28011303, PubMed:35147247, PubMed:8001561). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:27467858, PubMed:8001561). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717). Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear (PubMed:25344812). Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812). {ECO:0000250\|UniProtKB:P06802, ECO:0000269\|PubMed:10615944, ECO:0000269\|PubMed:25344812, ECO:0000269\|PubMed:27467858, ECO:0000269\|PubMed:28011303, ECO:0000269\|PubMed:28964717, ECO:0000269\|PubMed:35147247, ECO:0000269\|PubMed:8001561, ECO:0000305\|PubMed:11004006}.
P22695	UQCRC2	T369	ochoa	Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)	Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). {ECO:0000250\|UniProtKB:P07257, ECO:0000250\|UniProtKB:P23004, ECO:0000305\|PubMed:29243944}.
P23193	TCEA1	T262	ochoa	Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)	Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
P24534	EEF1B2	T88	ochoa	Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha)	Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A (By similarity). {ECO:0000250\|UniProtKB:P32471}.
P24844	MYL9	T19	ochoa\|psp	Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1)	Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity). {ECO:0000250\|UniProtKB:Q9CQ19, ECO:0000269\|PubMed:11942626, ECO:0000269\|PubMed:2526655}.
P26583	HMGB2	T22	ochoa	High mobility group protein B2 (High mobility group protein 2) (HMG-2)	Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:11909973, PubMed:18413230, PubMed:19522541, PubMed:19965638, PubMed:20123072, PubMed:7797075). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). {ECO:0000250\|UniProtKB:P09429, ECO:0000250\|UniProtKB:P30681, ECO:0000269\|PubMed:11909973, ECO:0000269\|PubMed:18413230, ECO:0000269\|PubMed:19522541, ECO:0000269\|PubMed:19811285, ECO:0000269\|PubMed:19965638, ECO:0000269\|PubMed:23877675, ECO:0000269\|PubMed:7797075, ECO:0000305\|PubMed:20123072}.
P26639	TARS1	T246	ochoa	Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). {ECO:0000250\|UniProtKB:Q9D0R2, ECO:0000269\|PubMed:25824639, ECO:0000269\|PubMed:31374204}.
P26641	EEF1G	T230	ochoa	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)	Probably plays a role in anchoring the complex to other cellular components.
P27448	MARK3	T536	ochoa	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)	Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269\|PubMed:12941695, ECO:0000269\|PubMed:16822840, ECO:0000269\|PubMed:16980613, ECO:0000269\|PubMed:23666762, ECO:0000269\|PubMed:28087714}.
P27448	MARK3	T95	psp	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)	Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269\|PubMed:12941695, ECO:0000269\|PubMed:16822840, ECO:0000269\|PubMed:16980613, ECO:0000269\|PubMed:23666762, ECO:0000269\|PubMed:28087714}.
P27816	MAP4	T712	ochoa	Microtubule-associated protein 4 (MAP-4)	Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269\|PubMed:10791892, ECO:0000269\|PubMed:34782749}.
P27816	MAP4	T812	ochoa	Microtubule-associated protein 4 (MAP-4)	Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269\|PubMed:10791892, ECO:0000269\|PubMed:34782749}.
P27816	MAP4	T819	ochoa	Microtubule-associated protein 4 (MAP-4)	Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269\|PubMed:10791892, ECO:0000269\|PubMed:34782749}.
P27816	MAP4	T872	ochoa	Microtubule-associated protein 4 (MAP-4)	Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269\|PubMed:10791892, ECO:0000269\|PubMed:34782749}.
P27816	MAP4	T917	ochoa\|psp	Microtubule-associated protein 4 (MAP-4)	Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269\|PubMed:10791892, ECO:0000269\|PubMed:34782749}.
P27986	PIK3R1	T603	ochoa	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)	Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). {ECO:0000269\|PubMed:17626883, ECO:0000269\|PubMed:19805105, ECO:0000269\|PubMed:20348923, ECO:0000269\|PubMed:7518429}.
P28290	ITPRID2	T87	ochoa	Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)	None
P28290	ITPRID2	T1156	ochoa	Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)	None
P28715	ERCC5	T338	ochoa	DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein)	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269\|PubMed:16246722, ECO:0000269\|PubMed:26833090, ECO:0000269\|PubMed:31253769, ECO:0000269\|PubMed:32522879, ECO:0000269\|PubMed:32821917, ECO:0000269\|PubMed:7651464, ECO:0000269\|PubMed:8078765, ECO:0000269\|PubMed:8090225, ECO:0000269\|PubMed:8206890, ECO:0000269\|PubMed:9927729}.
P28827	PTPRM	T873	ochoa	Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)	Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). {ECO:0000269\|PubMed:10753936, ECO:0000269\|PubMed:16456543, ECO:0000269\|PubMed:17761881, ECO:0000269\|PubMed:21998202}.
P29317	EPHA2	T838	ochoa	Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269\|PubMed:10655584, ECO:0000269\|PubMed:16236711, ECO:0000269\|PubMed:18339848, ECO:0000269\|PubMed:19573808, ECO:0000269\|PubMed:20679435, ECO:0000269\|PubMed:20861311, ECO:0000269\|PubMed:23358419, ECO:0000269\|PubMed:26158630, ECO:0000269\|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269\|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269\|PubMed:37146061}.
P30291	WEE1	T217	psp	Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)	Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269\|PubMed:15070733, ECO:0000269\|PubMed:7743995, ECO:0000269\|PubMed:8348613, ECO:0000269\|PubMed:8428596}.
P30307	CDC25C	T130	ochoa\|psp	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)	Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269\|PubMed:8119945}.
P30307	CDC25C	T261	ochoa	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)	Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269\|PubMed:8119945}.
P30622	CLIP1	T45	ochoa	CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)	Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269\|PubMed:12433698, ECO:0000269\|PubMed:17563362, ECO:0000269\|PubMed:17889670}.
P30622	CLIP1	T287	ochoa\|psp	CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)	Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269\|PubMed:12433698, ECO:0000269\|PubMed:17563362, ECO:0000269\|PubMed:17889670}.
P31270	HOXA11	T119	psp	Homeobox protein Hox-A11 (Homeobox protein Hox-1I)	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
P31949	S100A11	T37	ochoa	Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]	Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269\|PubMed:18618420}.
P32519	ELF1	T191	ochoa	ETS-related transcription factor Elf-1 (E74-like factor 1)	Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269\|PubMed:8756667}.
P33240	CSTF2	T106	ochoa	Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)	One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. {ECO:0000269\|PubMed:32816001, ECO:0000269\|PubMed:9199325}.
P33981	TTK	T453	ochoa\|psp	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)	Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269\|PubMed:18243099, ECO:0000269\|PubMed:28441529, ECO:0000269\|PubMed:29162720, ECO:0000269\|PubMed:30785839}.
P33981	TTK	T594	psp	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)	Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269\|PubMed:18243099, ECO:0000269\|PubMed:28441529, ECO:0000269\|PubMed:29162720, ECO:0000269\|PubMed:30785839}.
P34947	GRK5	T485	ochoa\|psp	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)	Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269\|PubMed:19661922, ECO:0000269\|PubMed:19801552, ECO:0000269\|PubMed:20038610, ECO:0000269\|PubMed:20124405, ECO:0000269\|PubMed:21728385}.
P35125	USP6	T1199	ochoa	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (RN-tre) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)	Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. May act as a GTPase-activating protein for RAB3A (PubMed:19077034). {ECO:0000269\|PubMed:15509780, ECO:0000269\|PubMed:16127172, ECO:0000269\|PubMed:19077034, ECO:0000269\|PubMed:20418905}.
P35222	CTNNB1	T298	psp	Catenin beta-1 (Beta-catenin)	Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250\|UniProtKB:Q02248, ECO:0000269\|PubMed:17524503, ECO:0000269\|PubMed:18077326, ECO:0000269\|PubMed:18086858, ECO:0000269\|PubMed:18957423, ECO:0000269\|PubMed:21262353, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22187462, ECO:0000269\|PubMed:22647378, ECO:0000269\|PubMed:22699938, ECO:0000269\|PubMed:29910125}.
P35251	RFC1	T163	ochoa	Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)	Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269\|PubMed:8999859, ECO:0000269\|PubMed:9488738}.
P35346	SSTR5	T333	psp	Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) (SST5)	Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. {ECO:0000269\|PubMed:12072395, ECO:0000269\|PubMed:7908405, ECO:0000269\|PubMed:8078491, ECO:0000269\|PubMed:8373420}.
P35579	MYH9	T383	ochoa	Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250\|UniProtKB:Q8VDD5, ECO:0000269\|PubMed:16707441, ECO:0000269\|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269\|PubMed:20944748, ECO:0000269\|PubMed:39048823}.
P35579	MYH9	T1155	ochoa	Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250\|UniProtKB:Q8VDD5, ECO:0000269\|PubMed:16707441, ECO:0000269\|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269\|PubMed:20944748, ECO:0000269\|PubMed:39048823}.
P35609	ACTN2	T237	ochoa	Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
P35749	MYH11	T604	ochoa	Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)	Muscle contraction.
P35749	MYH11	T1162	ochoa	Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)	Muscle contraction.
P36871	PGM1	T115	ochoa	Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)	Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269\|PubMed:15378030, ECO:0000269\|PubMed:17924679, ECO:0000269\|PubMed:25288802, ECO:0000305\|PubMed:15378030}.
P36871	PGM1	T467	psp	Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)	Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269\|PubMed:15378030, ECO:0000269\|PubMed:17924679, ECO:0000269\|PubMed:25288802, ECO:0000305\|PubMed:15378030}.
P36952	SERPINB5	T203	ochoa	Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)	Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
P37198	NUP62	T269	psp	Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62)	Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269\|PubMed:1915414, ECO:0000269\|PubMed:24107630}.
P37275	ZEB1	T530	ochoa	Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)	Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250\|UniProtKB:Q64318, ECO:0000269\|PubMed:19935649, ECO:0000269\|PubMed:20175752, ECO:0000269\|PubMed:20418909}.
P40926	MDH2	T213	ochoa	Malate dehydrogenase, mitochondrial (EC 1.1.1.37)	None
P40938	RFC3	T76	ochoa	Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)	Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. {ECO:0000269\|PubMed:9488738}.
P41208	CETN2	T118	psp	Centrin-2 (Caltractin isoform 1)	Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269\|PubMed:22307388, ECO:0000305\|PubMed:23591820}.
P41252	IARS1	T187	ochoa	Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269\|PubMed:8052601}.
P42345	MTOR	T308	psp	Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) (Tyrosine-protein kinase mTOR) (EC 2.7.10.2)	Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:31601708, PubMed:32561715, PubMed:34519269, PubMed:37751742). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (PubMed:15268862, PubMed:15467718, PubMed:17517883, PubMed:18372248, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:30171069, PubMed:29236692, PubMed:37751742). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (PubMed:15268862, PubMed:15467718, PubMed:18497260, PubMed:18925875, PubMed:20516213, PubMed:21576368, PubMed:21659604, PubMed:23429704, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470, PubMed:18497260, PubMed:18762023, PubMed:18925875, PubMed:20516213, PubMed:20537536, PubMed:21659604, PubMed:23429703, PubMed:23429704, PubMed:25799227, PubMed:26018084, PubMed:29150432, PubMed:29236692, PubMed:31112131, PubMed:34519269). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (PubMed:24403073, PubMed:29236692). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:12087098, PubMed:12150925, PubMed:18925875, PubMed:29150432, PubMed:29236692). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (PubMed:23429703, PubMed:23429704). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (PubMed:20516213). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (PubMed:36691768). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (PubMed:23426360). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (PubMed:32561715). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (PubMed:32561715). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (PubMed:20537536). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (PubMed:30704899). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (PubMed:23524951, PubMed:25438055). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (PubMed:21659604). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (PubMed:12231510). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors MITF, TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670, PubMed:36697823). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:24448649, PubMed:32612235, PubMed:36608670). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (PubMed:34289345). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15467718, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed:15467718, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957, PubMed:35926713). In contrast to mTORC1, mTORC2 is nutrient-insensitive (PubMed:15467718). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:15718470, PubMed:21376236, PubMed:24670654, PubMed:29424687, PubMed:29567957). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (PubMed:18925875). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (PubMed:15268862). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR; additional evidence are however required to confirm this result in vivo (PubMed:26584640). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity). {ECO:0000250\|UniProtKB:Q9JLN9, ECO:0000269\|PubMed:12087098, ECO:0000269\|PubMed:12150925, ECO:0000269\|PubMed:12150926, ECO:0000269\|PubMed:12231510, ECO:0000269\|PubMed:12718876, ECO:0000269\|PubMed:14651849, ECO:0000269\|PubMed:15268862, ECO:0000269\|PubMed:15467718, ECO:0000269\|PubMed:15545625, ECO:0000269\|PubMed:15718470, ECO:0000269\|PubMed:17517883, ECO:0000269\|PubMed:18372248, ECO:0000269\|PubMed:18497260, ECO:0000269\|PubMed:18762023, ECO:0000269\|PubMed:18925875, ECO:0000269\|PubMed:20516213, ECO:0000269\|PubMed:20537536, ECO:0000269\|PubMed:21376236, ECO:0000269\|PubMed:21576368, ECO:0000269\|PubMed:21659604, ECO:0000269\|PubMed:22343943, ECO:0000269\|PubMed:22576015, ECO:0000269\|PubMed:22692423, ECO:0000269\|PubMed:23426360, ECO:0000269\|PubMed:23429703, ECO:0000269\|PubMed:23429704, ECO:0000269\|PubMed:23524951, ECO:0000269\|PubMed:24403073, ECO:0000269\|PubMed:24448649, ECO:0000269\|PubMed:24670654, ECO:0000269\|PubMed:25438055, ECO:0000269\|PubMed:25799227, ECO:0000269\|PubMed:26018084, ECO:0000269\|PubMed:26584640, ECO:0000269\|PubMed:29150432, ECO:0000269\|PubMed:29236692, ECO:0000269\|PubMed:29424687, ECO:0000269\|PubMed:29567957, ECO:0000269\|PubMed:30171069, ECO:0000269\|PubMed:30704899, ECO:0000269\|PubMed:31112131, ECO:0000269\|PubMed:31601708, ECO:0000269\|PubMed:31695197, ECO:0000269\|PubMed:32561715, ECO:0000269\|PubMed:32612235, ECO:0000269\|PubMed:34289345, ECO:0000269\|PubMed:34519269, ECO:0000269\|PubMed:35926713, ECO:0000269\|PubMed:36608670, ECO:0000269\|PubMed:36691768, ECO:0000269\|PubMed:36697823, ECO:0000269\|PubMed:37751742}.
P42685	FRK	T178	ochoa	Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269\|PubMed:19345329}.
P42704	LRPPRC	T1030	ochoa	Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130)	May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101). {ECO:0000250, ECO:0000269\|PubMed:11585913, ECO:0000269\|PubMed:12832482, ECO:0000269\|PubMed:15081402, ECO:0000269\|PubMed:15139850, ECO:0000269\|PubMed:15272088, ECO:0000269\|PubMed:17050673, ECO:0000269\|PubMed:19262567, ECO:0000269\|PubMed:23822101, ECO:0000269\|PubMed:28325843}.
P43007	SLC1A4	T511	ochoa	Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (Solute carrier family 1 member 4)	Sodium-dependent neutral amino-acid transporter that mediates transport of alanine, serine, cysteine, proline, hydroxyproline and threonine. {ECO:0000269\|PubMed:14502423, ECO:0000269\|PubMed:26041762, ECO:0000269\|PubMed:8101838, ECO:0000269\|PubMed:8340364}.
P43250	GRK6	T485	ochoa\|psp	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269\|PubMed:19801552, ECO:0000269\|PubMed:20048153}.
P43403	ZAP70	T494	ochoa	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Also contributes to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR and to relieve its autoinhibited conformation. Release of ZAP70 active conformation is further stabilized by phosphorylation mediated by LCK. Subsequently, ZAP70 phosphorylates at least 2 essential adapter proteins: LAT and LCP2. In turn, a large number of signaling molecules are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Furthermore, ZAP70 controls cytoskeleton modifications, adhesion and mobility of T-lymphocytes, thus ensuring correct delivery of effectors to the APC. ZAP70 is also required for TCR-CD247/CD3Z internalization and degradation through interaction with the E3 ubiquitin-protein ligase CBL and adapter proteins SLA and SLA2. Thus, ZAP70 regulates both T-cell activation switch on and switch off by modulating TCR expression at the T-cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection (when cells are still CD4/CD8 double negative). Additionally, ZAP70-dependent signaling pathway may also contribute to primary B-cells formation and activation through B-cell receptor (BCR). {ECO:0000269\|PubMed:11353765, ECO:0000269\|PubMed:12051764, ECO:0000269\|PubMed:1423621, ECO:0000269\|PubMed:20135127, ECO:0000269\|PubMed:26903241, ECO:0000269\|PubMed:38614099, ECO:0000269\|PubMed:8124727, ECO:0000269\|PubMed:8702662, ECO:0000269\|PubMed:9489702}.
P43630	KIR3DL2	T429	ochoa	Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor clone CL-5) (p70 NK receptor CL-5) (CD antigen CD158k)	Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270). Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464). {ECO:0000269\|PubMed:24018270, ECO:0000269\|PubMed:26928464, ECO:0000269\|PubMed:28636952}.
P46013	MKI67	T1449	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T2502	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46063	RECQL	T511	ochoa	ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)	DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:15886194, PubMed:35025765, PubMed:7527136, PubMed:7961977, PubMed:8056767). Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:19151156, PubMed:35025765, PubMed:7527136, PubMed:8056767). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). Does not unwind G-quadruplex DNA (PubMed:18426915). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:15886194, PubMed:7961977). {ECO:0000269\|PubMed:15886194, ECO:0000269\|PubMed:18426915, ECO:0000269\|PubMed:19151156, ECO:0000269\|PubMed:25831490, ECO:0000269\|PubMed:35025765, ECO:0000269\|PubMed:7527136, ECO:0000269\|PubMed:7961977, ECO:0000269\|PubMed:8056767}.
P46087	NOP2	T596	ochoa	28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)	S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269\|PubMed:24120868, ECO:0000269\|PubMed:26196125, ECO:0000269\|PubMed:36161484}.
P46100	ATRX	T591	ochoa	Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)	Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269\|PubMed:12953102, ECO:0000269\|PubMed:14990586, ECO:0000269\|PubMed:20504901, ECO:0000269\|PubMed:20651253, ECO:0000269\|PubMed:21029860, ECO:0000269\|PubMed:22391447, ECO:0000269\|PubMed:22829774, ECO:0000269\|PubMed:24500201, ECO:0000269\|PubMed:27029610}.
P46821	MAP1B	T744	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P47736	RAP1GAP	T522	ochoa	Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1)	GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269\|PubMed:15141215}.
P48048	KCNJ1	T191	psp	ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269\|PubMed:16357011, ECO:0000269\|PubMed:7929082}.
P48544	KCNJ5	T199	psp	G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins. {ECO:0000269\|PubMed:22315453, ECO:0000269\|PubMed:22628607, ECO:0000269\|PubMed:24037882, ECO:0000269\|PubMed:27099398, ECO:0000269\|PubMed:27293068, ECO:0000269\|PubMed:8558261, ECO:0000269\|PubMed:8868049}.
P48735	IDH2	T350	ochoa	Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)	Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140). {ECO:0000269\|PubMed:19228619, ECO:0000269\|PubMed:22416140}.
P48741	HSPA7	T68	ochoa	Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B) (Heat shock protein family A member 7)	None
P49327	FASN	T1053	ochoa	Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]	Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269\|PubMed:16215233, ECO:0000269\|PubMed:16969344, ECO:0000269\|PubMed:26851298, ECO:0000269\|PubMed:7567999, ECO:0000269\|PubMed:8962082, ECO:0000269\|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269\|PubMed:34320401}.
P49368	CCT3	T512	psp	T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) (Chaperonin containing T-complex polypeptide 1 subunit 3) (hTRiC5)	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000269\|PubMed:35449234, ECO:0000269\|PubMed:36493755, ECO:0000269\|PubMed:37193829}.
P49427	CDC34	T162	psp	Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)	E2 ubiquitin-conjugating enzyme that accepts ubiquitin from an E1 ubiquitin-activating protein, and catalyzes its covalent attachment to other proteins by an E3 ubiquitin-protein ligase complex (PubMed:10329681, PubMed:17588522, PubMed:20061386, PubMed:38326650). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation (PubMed:10329681, PubMed:10918611, PubMed:17698585). Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1 (PubMed:10871850, PubMed:15652359, PubMed:19112177). Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation (PubMed:19126550). Also involved in the degradation of beta-catenin (PubMed:12037680). Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes (PubMed:11805320, PubMed:12060736). {ECO:0000269\|PubMed:10329681, ECO:0000269\|PubMed:10871850, ECO:0000269\|PubMed:10918611, ECO:0000269\|PubMed:11805320, ECO:0000269\|PubMed:12037680, ECO:0000269\|PubMed:12060736, ECO:0000269\|PubMed:15652359, ECO:0000269\|PubMed:17588522, ECO:0000269\|PubMed:17698585, ECO:0000269\|PubMed:19112177, ECO:0000269\|PubMed:19126550, ECO:0000269\|PubMed:20061386, ECO:0000269\|PubMed:22496338, ECO:0000269\|PubMed:38326650}.
P49448	GLUD2	T409	ochoa	Glutamate dehydrogenase 2, mitochondrial (GDH 2) (EC 1.4.1.3)	Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
P49589	CARS1	T58	ochoa	Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)	Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). {ECO:0000269\|PubMed:11347887, ECO:0000269\|PubMed:30824121}.
P49736	MCM2	T457	ochoa	DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)	Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269\|PubMed:26196677, ECO:0000269\|PubMed:32453425, ECO:0000269\|PubMed:34694004, ECO:0000269\|PubMed:34700328, ECO:0000269\|PubMed:35585232, ECO:0000269\|PubMed:8175912}.
P49790	NUP153	T413	psp	Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269\|PubMed:12802065, ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269\|PubMed:23523133, ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269\|PubMed:24130490, ECO:0000269\|PubMed:31913756}.
P49792	RANBP2	T1517	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49792	RANBP2	T1644	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49792	RANBP2	T2450	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49792	RANBP2	T2541	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49848	TAF6	T120	ochoa	Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80)	The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473). {ECO:0000269\|PubMed:33795473}.; FUNCTION: [Isoform 4]: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). {ECO:0000269\|PubMed:11583621, ECO:0000269\|PubMed:18628956, ECO:0000269\|PubMed:20096117, ECO:0000269\|PubMed:29358700}.
P49916	LIG3	T204	ochoa	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)	Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269\|PubMed:10207110, ECO:0000269\|PubMed:24674627}.
P50395	GDI2	T122	ochoa	Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)	GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269\|PubMed:25860027}.
P50851	LRBA	T1253	ochoa	Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)	Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250\|UniProtKB:Q9ESE1, ECO:0000269\|PubMed:33773106}.
P51587	BRCA2	T3323	ochoa	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)	Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269\|PubMed:15115758, ECO:0000269\|PubMed:15199141, ECO:0000269\|PubMed:15671039, ECO:0000269\|PubMed:18317453, ECO:0000269\|PubMed:20729832, ECO:0000269\|PubMed:20729858, ECO:0000269\|PubMed:20729859, ECO:0000269\|PubMed:21084279, ECO:0000269\|PubMed:21719596, ECO:0000269\|PubMed:24485656, ECO:0000269\|PubMed:24896180}.
P51610	HCFC1	T498	ochoa	Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]	Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250\|UniProtKB:D3ZN95, ECO:0000269\|PubMed:10629049, ECO:0000269\|PubMed:10675337, ECO:0000269\|PubMed:10779346, ECO:0000269\|PubMed:12244100, ECO:0000269\|PubMed:12670868, ECO:0000269\|PubMed:14532282, ECO:0000269\|PubMed:15190068, ECO:0000269\|PubMed:16624878, ECO:0000269\|PubMed:20018852, ECO:0000269\|PubMed:20200153, ECO:0000269\|PubMed:23629655, ECO:0000269\|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269\|PubMed:10629049, ECO:0000269\|PubMed:17578910}.
P51809	VAMP7	T170	ochoa	Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP)	Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269\|PubMed:10888671, ECO:0000269\|PubMed:16677249, ECO:0000269\|PubMed:18042464}.
P52569	SLC7A2	T28	ochoa	Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)	Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:28684763, PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). {ECO:0000250\|UniProtKB:P18581, ECO:0000269\|PubMed:28684763, ECO:0000269\|PubMed:9174363}.; FUNCTION: [Isoform 1]: Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2. {ECO:0000269\|PubMed:28684763, ECO:0000269\|PubMed:9174363}.; FUNCTION: [Isoform 2]: Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). {ECO:0000269\|PubMed:28684763, ECO:0000269\|PubMed:9174363}.
P54132	BLM	T508	ochoa	RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)	ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250\|UniProtKB:O88700, ECO:0000269\|PubMed:12019152, ECO:0000269\|PubMed:18426915, ECO:0000269\|PubMed:20639533, ECO:0000269\|PubMed:21325134, ECO:0000269\|PubMed:23509288, ECO:0000269\|PubMed:24257077, ECO:0000269\|PubMed:24816114, ECO:0000269\|PubMed:25901030, ECO:0000269\|PubMed:34606619, ECO:0000269\|PubMed:9388193, ECO:0000269\|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269\|PubMed:32690953}.
P54760	EPHB4	T587	ochoa	Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269\|PubMed:12734395, ECO:0000269\|PubMed:16424904, ECO:0000269\|PubMed:27400125, ECO:0000269\|PubMed:30578106}.
P54819	AK2	T194	ochoa	Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. {ECO:0000255\|HAMAP-Rule:MF_03168, ECO:0000269\|PubMed:19043416}.
P55011	SLC12A2	T986	ochoa	Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1)	Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269\|PubMed:16669787, ECO:0000269\|PubMed:32081947, ECO:0000269\|PubMed:32294086, ECO:0000269\|PubMed:33597714, ECO:0000269\|PubMed:35585053, ECO:0000269\|PubMed:36239040, ECO:0000269\|PubMed:36306358, ECO:0000269\|PubMed:7629105}.
P55196	AFDN	T214	ochoa	Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)	Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250\|UniProtKB:O35889, ECO:0000250\|UniProtKB:Q9QZQ1, ECO:0000269\|PubMed:11024295, ECO:0000269\|PubMed:30463011}.
P55196	AFDN	T1101	ochoa	Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)	Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250\|UniProtKB:O35889, ECO:0000250\|UniProtKB:Q9QZQ1, ECO:0000269\|PubMed:11024295, ECO:0000269\|PubMed:30463011}.
P55211	CASP9	T107	ochoa	Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269\|PubMed:15657060, ECO:0000269\|PubMed:16352606, ECO:0000269\|PubMed:16916640, ECO:0000269\|PubMed:23516580, ECO:0000269\|PubMed:27889207, ECO:0000269\|PubMed:35338844, ECO:0000269\|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269\|PubMed:10070954}.
P55265	ADAR	T808	ochoa	Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP)	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269\|PubMed:12618436, ECO:0000269\|PubMed:15556947, ECO:0000269\|PubMed:15858013, ECO:0000269\|PubMed:16120648, ECO:0000269\|PubMed:16475990, ECO:0000269\|PubMed:17079286, ECO:0000269\|PubMed:19605474, ECO:0000269\|PubMed:19651874, ECO:0000269\|PubMed:19710021, ECO:0000269\|PubMed:19908260, ECO:0000269\|PubMed:21289159, ECO:0000269\|PubMed:22278222, ECO:0000269\|PubMed:7565688, ECO:0000269\|PubMed:7972084}.
P56192	MARS1	T833	ochoa	Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). {ECO:0000269\|PubMed:10791971, ECO:0000269\|PubMed:11714285, ECO:0000269\|PubMed:33909043}.
P58876	H2BC5	Y38	ochoa	Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P60983	GMFB	T27	psp	Glia maturation factor beta (GMF-beta)	This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
P61073	CXCR4	T318	ochoa	C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:18799424, PubMed:24912431, PubMed:28978524). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). {ECO:0000250\|UniProtKB:P70658, ECO:0000269\|PubMed:10074102, ECO:0000269\|PubMed:10452968, ECO:0000269\|PubMed:10644702, ECO:0000269\|PubMed:10825158, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:17197449, ECO:0000269\|PubMed:18799424, ECO:0000269\|PubMed:20048153, ECO:0000269\|PubMed:20228059, ECO:0000269\|PubMed:20505072, ECO:0000269\|PubMed:24912431, ECO:0000269\|PubMed:28978524, ECO:0000269\|PubMed:8752280, ECO:0000269\|PubMed:8752281}.; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:10074122, PubMed:10756055, PubMed:8849450, PubMed:8929542, PubMed:9427609). {ECO:0000269\|PubMed:10074122, ECO:0000269\|PubMed:10756055, ECO:0000269\|PubMed:8849450, ECO:0000269\|PubMed:8929542, ECO:0000269\|PubMed:9427609}.
P61353	RPL27	T83	ochoa	Large ribosomal subunit protein eL27 (60S ribosomal protein L27)	Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:25424902, ECO:0000269\|PubMed:25901680, ECO:0000269\|PubMed:25957688, ECO:0000269\|PubMed:32669547, ECO:0000305\|PubMed:12962325}.
P62191	PSMC1	T369	ochoa	26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269\|PubMed:1317798}.
P62495	ETF1	T32	ochoa	Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)	Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, PubMed:7990965). The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:26245381, PubMed:27863242, PubMed:36638793). ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:26245381, PubMed:27863242, PubMed:36638793). Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:10676813, PubMed:16777602, PubMed:26245381, PubMed:27863242). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (PubMed:19417104). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371). {ECO:0000269\|PubMed:10676813, ECO:0000269\|PubMed:16777602, ECO:0000269\|PubMed:19417104, ECO:0000269\|PubMed:24486019, ECO:0000269\|PubMed:26245381, ECO:0000269\|PubMed:27863242, ECO:0000269\|PubMed:30682371, ECO:0000269\|PubMed:36638793, ECO:0000269\|PubMed:7990965}.
P62807	H2BC4	Y38	ochoa	Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
P68366	TUBA4A	T50	ochoa	Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain)	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P78316	NOP14	T236	ochoa	Nucleolar protein 14 (Nucleolar complex protein 14)	Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}.
P78345	RPP38	T255	ochoa	Ribonuclease P protein subunit p38 (RNaseP protein p38)	Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:10444065, PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269\|PubMed:10444065, ECO:0000269\|PubMed:28115465, ECO:0000269\|PubMed:30454648, ECO:0000269\|PubMed:9037013, ECO:0000269\|PubMed:9630247}.
P78347	GTF2I	T96	ochoa	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269\|PubMed:10373551, ECO:0000269\|PubMed:11373296, ECO:0000269\|PubMed:16738337}.
P78347	GTF2I	T549	ochoa	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269\|PubMed:10373551, ECO:0000269\|PubMed:11373296, ECO:0000269\|PubMed:16738337}.
P78371	CCT2	T246	ochoa	T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000269\|PubMed:35449234, ECO:0000269\|PubMed:36493755, ECO:0000269\|PubMed:37193829}.
P82094	TMF1	T929	ochoa	TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa)	Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269\|PubMed:10428808, ECO:0000269\|PubMed:1409643, ECO:0000269\|PubMed:15467733, ECO:0000269\|PubMed:17698061}.
P84022	SMAD3	T388	psp	Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269\|PubMed:10995748, ECO:0000269\|PubMed:15241418, ECO:0000269\|PubMed:15588252, ECO:0000269\|PubMed:16156666, ECO:0000269\|PubMed:16751101, ECO:0000269\|PubMed:16862174, ECO:0000269\|PubMed:17327236, ECO:0000269\|PubMed:19218245, ECO:0000269\|PubMed:19289081, ECO:0000269\|PubMed:9732876, ECO:0000269\|PubMed:9892009}.
P98168	ZXDA	T721	ochoa	Zinc finger X-linked protein ZXDA	Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269\|PubMed:17493635}.
P98169	ZXDB	T725	ochoa	Zinc finger X-linked protein ZXDB	Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000250}.
Q00013	MPP1	T384	ochoa	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)	Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}.
Q00839	HNRNPU	T474	ochoa	Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120)	DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression (PubMed:10490622, PubMed:18082603, PubMed:19029303, PubMed:22325991, PubMed:25986610, PubMed:28622508). Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (PubMed:1324173, PubMed:28622508, PubMed:8174554). Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator (PubMed:10490622, PubMed:15711563, PubMed:19617346, PubMed:23811339, PubMed:8174554, PubMed:9353307). Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner (PubMed:10490622, PubMed:15711563). Blocks Pol II transcription elongation activity by inhibiting the C-terminal domain (CTD) phosphorylation of Pol II and dissociates from Pol II pre-initiation complex prior to productive transcription elongation (PubMed:10490622). Positively regulates CBX5-induced transcriptional gene silencing and retention of CBX5 in the nucleus (PubMed:19617346). Negatively regulates glucocorticoid-mediated transcriptional activation (PubMed:9353307). Key regulator of transcription initiation and elongation in embryonic stem cells upon leukemia inhibitory factor (LIF) signaling (By similarity). Involved in the long non-coding RNA H19-mediated Pol II transcriptional repression (PubMed:23811339). Participates in the circadian regulation of the core clock component BMAL1 transcription (By similarity). Plays a role in the regulation of telomere length (PubMed:18082603). Plays a role as a global pre-mRNA alternative splicing modulator by regulating U2 small nuclear ribonucleoprotein (snRNP) biogenesis (PubMed:22325991). Plays a role in mRNA stability (PubMed:17174306, PubMed:17289661, PubMed:19029303). Component of the CRD-mediated complex that promotes MYC mRNA stabilization (PubMed:19029303). Enhances the expression of specific genes, such as tumor necrosis factor TNFA, by regulating mRNA stability, possibly through binding to the 3'-untranslated region (UTR) (PubMed:17174306). Plays a role in mitotic cell cycle regulation (PubMed:21242313, PubMed:25986610). Involved in the formation of stable mitotic spindle microtubules (MTs) attachment to kinetochore, spindle organization and chromosome congression (PubMed:21242313). Phosphorylation at Ser-59 by PLK1 is required for chromosome alignement and segregation and progression through mitosis (PubMed:25986610). Also contributes to the targeting of AURKA to mitotic spindle MTs (PubMed:21242313). Binds to double- and single-stranded DNA and RNA, poly(A), poly(C) and poly(G) oligoribonucleotides (PubMed:1628625, PubMed:8068679, PubMed:8174554, PubMed:9204873, PubMed:9405365). Binds to chromatin-associated RNAs (caRNAs) (PubMed:28622508). Associates with chromatin to scaffold/matrix attachment region (S/MAR) elements in a chromatin-associated RNAs (caRNAs)-dependent manner (PubMed:10671544, PubMed:11003645, PubMed:11909954, PubMed:1324173, PubMed:28622508, PubMed:7509195, PubMed:9204873, PubMed:9405365). Binds to the Xist RNA (PubMed:26244333). Binds the long non-coding H19 RNA (PubMed:23811339). Binds to SMN1/2 pre-mRNAs at G/U-rich regions (PubMed:22325991). Binds to small nuclear RNAs (snRNAs) (PubMed:22325991). Binds to the 3'-UTR of TNFA mRNA (PubMed:17174306). Binds (via RNA-binding RGG-box region) to the long non-coding Xist RNA; this binding is direct and bridges the Xist RNA and the inactive chromosome X (Xi) (By similarity). Also negatively regulates embryonic stem cell differentiation upon LIF signaling (By similarity). Required for embryonic development (By similarity). Binds to brown fat long non-coding RNA 1 (Blnc1); facilitates the recruitment of Blnc1 by ZBTB7B required to drive brown and beige fat development and thermogenesis (By similarity). {ECO:0000250\|UniProtKB:Q8VEK3, ECO:0000269\|PubMed:10490622, ECO:0000269\|PubMed:10671544, ECO:0000269\|PubMed:11003645, ECO:0000269\|PubMed:11909954, ECO:0000269\|PubMed:1324173, ECO:0000269\|PubMed:15711563, ECO:0000269\|PubMed:1628625, ECO:0000269\|PubMed:17174306, ECO:0000269\|PubMed:17289661, ECO:0000269\|PubMed:18082603, ECO:0000269\|PubMed:19029303, ECO:0000269\|PubMed:19617346, ECO:0000269\|PubMed:21242313, ECO:0000269\|PubMed:22325991, ECO:0000269\|PubMed:23811339, ECO:0000269\|PubMed:25986610, ECO:0000269\|PubMed:26244333, ECO:0000269\|PubMed:28622508, ECO:0000269\|PubMed:7509195, ECO:0000269\|PubMed:8068679, ECO:0000269\|PubMed:8174554, ECO:0000269\|PubMed:9204873, ECO:0000269\|PubMed:9353307, ECO:0000269\|PubMed:9405365}.; FUNCTION: (Microbial infection) Negatively regulates immunodeficiency virus type 1 (HIV-1) replication by preventing the accumulation of viral mRNA transcripts in the cytoplasm. {ECO:0000269\|PubMed:16916646}.
Q00872	MYBPC1	T802	ochoa	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269\|PubMed:31025394, ECO:0000269\|PubMed:31264822}.
Q01082	SPTBN1	T2187	ochoa	Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)	Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269\|PubMed:34211179}.
Q01094	E2F1	T130	psp	Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:10675335, PubMed:12717439, PubMed:17050006, PubMed:17704056, PubMed:18625225, PubMed:28992046). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase (PubMed:10675335, PubMed:12717439, PubMed:17704056). E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed:10675335, PubMed:12717439, PubMed:17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed:8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Directly activates transcription of PEG10 (PubMed:17050006, PubMed:18625225, PubMed:28992046). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000269\|PubMed:10675335, ECO:0000269\|PubMed:12717439, ECO:0000269\|PubMed:17050006, ECO:0000269\|PubMed:17704056, ECO:0000269\|PubMed:18625225, ECO:0000269\|PubMed:20040599, ECO:0000269\|PubMed:20176812, ECO:0000269\|PubMed:28992046, ECO:0000269\|PubMed:8170954}.
Q01780	EXOSC10	T196	ochoa	Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)	Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA. Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (PubMed:25632158, PubMed:31086179). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (PubMed:31086179). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (PubMed:26857222, PubMed:36912080). Required for cell proliferation (PubMed:36912080). Regulates metabolism of C9orf72-derived repeat RNA that can be translated into toxic dipeptide repeat proteins (PubMed:32830871). {ECO:0000250\|UniProtKB:P56960, ECO:0000269\|PubMed:14527413, ECO:0000269\|PubMed:16455498, ECO:0000269\|PubMed:17412707, ECO:0000269\|PubMed:17545563, ECO:0000269\|PubMed:18172165, ECO:0000269\|PubMed:19056938, ECO:0000269\|PubMed:20368444, ECO:0000269\|PubMed:20699273, ECO:0000269\|PubMed:25632158, ECO:0000269\|PubMed:26857222, ECO:0000269\|PubMed:31086179, ECO:0000269\|PubMed:32830871, ECO:0000269\|PubMed:34516797, ECO:0000269\|PubMed:36912080}.
Q01831	XPC	T340	ochoa	DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125)	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex (PubMed:10734143, PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19609301, PubMed:19941824, PubMed:20028083, PubMed:20649465, PubMed:20798892, PubMed:9734359). Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides (PubMed:10734143, PubMed:19609301, PubMed:20649465). This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity (PubMed:10734143, PubMed:19609301, PubMed:20649465). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). The orientation of XPC complex binding appears to be crucial for inducing a productive NER (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (PubMed:10873465, PubMed:12509299, PubMed:12547395, PubMed:19941824, PubMed:20028083, PubMed:20798892, PubMed:9734359). In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts (PubMed:20028083). XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1 (PubMed:20028083). {ECO:0000269\|PubMed:10734143, ECO:0000269\|PubMed:10873465, ECO:0000269\|PubMed:12509299, ECO:0000269\|PubMed:12547395, ECO:0000269\|PubMed:19609301, ECO:0000269\|PubMed:19941824, ECO:0000269\|PubMed:20028083, ECO:0000269\|PubMed:20649465, ECO:0000269\|PubMed:20798892, ECO:0000269\|PubMed:9734359}.; FUNCTION: In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT) (PubMed:29973595, PubMed:31527837). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes (PubMed:31527837). {ECO:0000269\|PubMed:29973595, ECO:0000269\|PubMed:31527837}.
Q02952	AKAP12	T723	ochoa	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03164	KMT2A	T923	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q03164	KMT2A	T1245	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q03188	CENPC	T372	ochoa	Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7)	Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269\|PubMed:19482874, ECO:0000269\|PubMed:21529714}.
Q03701	CEBPZ	T669	ochoa	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor)	Stimulates transcription from the HSP70 promoter.
Q04656	ATP7A	T150	ochoa	Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein)	ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:10419525, PubMed:19453293, PubMed:19917612, PubMed:28389643, PubMed:31283225). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (PubMed:11092760, PubMed:28389643). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (PubMed:10419525, PubMed:28389643). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity) (PubMed:28389643). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity). {ECO:0000250\|UniProtKB:Q64430, ECO:0000269\|PubMed:10419525, ECO:0000269\|PubMed:11092760, ECO:0000269\|PubMed:19453293, ECO:0000269\|PubMed:19917612, ECO:0000269\|PubMed:28389643, ECO:0000269\|PubMed:31283225}.
Q04724	TLE1	T290	ochoa	Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)	Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000250\|UniProtKB:Q62440, ECO:0000269\|PubMed:10660609}.
Q05519	SRSF11	T325	ochoa	Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11)	May function in pre-mRNA splicing.
Q05655	PRKCD	T295	ochoa\|psp	Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250\|UniProtKB:P28867, ECO:0000269\|PubMed:11748588, ECO:0000269\|PubMed:11877440, ECO:0000269\|PubMed:12649167, ECO:0000269\|PubMed:15774464, ECO:0000269\|PubMed:16940418, ECO:0000269\|PubMed:17303575, ECO:0000269\|PubMed:18285462, ECO:0000269\|PubMed:19587372, ECO:0000269\|PubMed:19801500, ECO:0000303\|PubMed:21406692, ECO:0000303\|PubMed:21810427}.
Q07157	TJP1	T770	psp	Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250\|UniProtKB:O97758, ECO:0000250\|UniProtKB:P39447, ECO:0000269\|PubMed:20930113, ECO:0000269\|PubMed:21240187}.
Q07157	TJP1	T1528	ochoa	Tight junction protein 1 (Tight junction protein ZO-1) (Zona occludens protein 1) (Zonula occludens protein 1)	TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250\|UniProtKB:O97758, ECO:0000250\|UniProtKB:P39447, ECO:0000269\|PubMed:20930113, ECO:0000269\|PubMed:21240187}.
Q07343	PDE4B	T292	ochoa	3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B)	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269\|PubMed:10846163, ECO:0000269\|PubMed:15003452, ECO:0000269\|PubMed:15260978}.
Q07343	PDE4B	T323	ochoa	3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B)	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269\|PubMed:10846163, ECO:0000269\|PubMed:15003452, ECO:0000269\|PubMed:15260978}.
Q08043	ACTN3	T244	ochoa	Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Q08AD1	CAMSAP2	T724	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q08AE8	SPIRE1	T509	ochoa	Protein spire homolog 1 (Spir-1)	Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269\|PubMed:11747823, ECO:0000269\|PubMed:21620703, ECO:0000269\|PubMed:26287480, ECO:0000269\|PubMed:35148361}.
Q09666	AHNAK	T2832	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	T3366	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q09666	AHNAK	T5415	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q12800	TFCP2	T258	psp	Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF)	Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269\|PubMed:10455131, ECO:0000269\|PubMed:1732747, ECO:0000269\|PubMed:8035790, ECO:0000269\|PubMed:8157699}.
Q12824	SMARCB1	T134	ochoa	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)	Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. {ECO:0000250\|UniProtKB:Q9Z0H3, ECO:0000269\|PubMed:10078207, ECO:0000269\|PubMed:12226744, ECO:0000269\|PubMed:14604992, ECO:0000269\|PubMed:16267391, ECO:0000269\|PubMed:16314535, ECO:0000269\|PubMed:9448295}.
Q12965	MYO1E	T936	ochoa	Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E)	Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269\|PubMed:11940582, ECO:0000269\|PubMed:17257598, ECO:0000269\|PubMed:20860408, ECO:0000269\|PubMed:36316095}.
Q12983	BNIP3	T140	psp	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269\|PubMed:19935772, ECO:0000269\|PubMed:22292033}.
Q12983	BNIP3	T148	psp	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269\|PubMed:19935772, ECO:0000269\|PubMed:22292033}.
Q13112	CHAF1B	T397	ochoa	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7)	Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269\|PubMed:9813080}.
Q13203	MYBPH	T183	ochoa	Myosin-binding protein H (MyBP-H) (H-protein)	Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
Q13415	ORC1	T203	ochoa	Origin recognition complex subunit 1 (Replication control protein 1)	Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Q13422	IKZF1	T291	ochoa	DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)	Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250\|UniProtKB:Q03267, ECO:0000269\|PubMed:10204490, ECO:0000269\|PubMed:17135265, ECO:0000269\|PubMed:17934067, ECO:0000269\|PubMed:19141594}.
Q13428	TCOF1	T1358	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13435	SF3B2	T780	ochoa	Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). {ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:12234937, ECO:0000269\|PubMed:15146077, ECO:0000269\|PubMed:27720643, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:33509932, ECO:0000269\|PubMed:34822310}.
Q13464	ROCK1	T1000	ochoa	Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)	Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250\|UniProtKB:P70335, ECO:0000250\|UniProtKB:Q8MIT6, ECO:0000269\|PubMed:10436159, ECO:0000269\|PubMed:10652353, ECO:0000269\|PubMed:11018042, ECO:0000269\|PubMed:11283607, ECO:0000269\|PubMed:17158456, ECO:0000269\|PubMed:18573880, ECO:0000269\|PubMed:18694941, ECO:0000269\|PubMed:19036714, ECO:0000269\|PubMed:19131646, ECO:0000269\|PubMed:19181962, ECO:0000269\|PubMed:19997641, ECO:0000269\|PubMed:21072057, ECO:0000269\|PubMed:23093407, ECO:0000269\|PubMed:23355470, ECO:0000269\|PubMed:8617235, ECO:0000269\|PubMed:9722579}.
Q13554	CAMK2B	T311	ochoa	Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741). {ECO:0000250\|UniProtKB:P08413, ECO:0000269\|PubMed:16690701, ECO:0000269\|PubMed:29100089, ECO:0000269\|PubMed:31930741}.
Q13557	CAMK2D	T311	ochoa	Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)	Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250\|UniProtKB:Q6PHZ2, ECO:0000269\|PubMed:16690701, ECO:0000269\|PubMed:17179159}.
Q13561	DCTN2	T195	ochoa	Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin)	Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250\|UniProtKB:A0A5G2QD80, ECO:0000250\|UniProtKB:Q99KJ8}.
Q13573	SNW1	T180	ochoa	SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269\|PubMed:10644367, ECO:0000269\|PubMed:11278756, ECO:0000269\|PubMed:11371506, ECO:0000269\|PubMed:11514567, ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:12840015, ECO:0000269\|PubMed:14985122, ECO:0000269\|PubMed:15194481, ECO:0000269\|PubMed:15905409, ECO:0000269\|PubMed:18794151, ECO:0000269\|PubMed:19818711, ECO:0000269\|PubMed:21245387, ECO:0000269\|PubMed:21460037, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:9632709, ECO:0000305\|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269\|PubMed:15905409, ECO:0000269\|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269\|PubMed:10644367}.
Q13772	NCOA4	T514	ochoa	Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1)	Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269\|PubMed:10347167, ECO:0000269\|PubMed:10517667, ECO:0000269\|PubMed:24910095, ECO:0000269\|PubMed:25327288, ECO:0000269\|PubMed:26436293, ECO:0000269\|PubMed:8643607}.
Q13813	SPTAN1	T1000	ochoa	Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)	Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Q13835	PKP1	T179	ochoa\|psp	Plakophilin-1 (Band 6 protein) (B6P)	A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250\|UniProtKB:P97350, ECO:0000269\|PubMed:10852826, ECO:0000269\|PubMed:20156963, ECO:0000269\|PubMed:20613778, ECO:0000269\|PubMed:23444369, ECO:0000269\|PubMed:25225333, ECO:0000269\|PubMed:31835537, ECO:0000269\|PubMed:9326952}.
Q13838	DDX39B	T172	ochoa	Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)	Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269\|PubMed:11675789, ECO:0000269\|PubMed:15585580, ECO:0000269\|PubMed:15833825, ECO:0000269\|PubMed:15998806, ECO:0000269\|PubMed:17190602, ECO:0000269\|PubMed:17562711, ECO:0000269\|PubMed:17984224, ECO:0000269\|PubMed:20844015, ECO:0000269\|PubMed:22144908, ECO:0000269\|PubMed:23222130, ECO:0000269\|PubMed:23299939, ECO:0000269\|PubMed:33191911, ECO:0000269\|PubMed:37578863, ECO:0000269\|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269\|PubMed:23299939, ECO:0000269\|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269\|PubMed:18974867}.
Q14008	CKAP5	T569	ochoa	Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG)	Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269\|PubMed:12569123, ECO:0000269\|PubMed:18809577, ECO:0000269\|PubMed:21297582, ECO:0000269\|PubMed:21646404, ECO:0000269\|PubMed:23532825, ECO:0000269\|PubMed:27156448, ECO:0000269\|PubMed:9570755}.
Q14118	DAG1	T790	ochoa	Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]	The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; FUNCTION: [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). {ECO:0000250\|UniProtKB:O18738}.; FUNCTION: [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; FUNCTION: [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927). {ECO:0000269\|PubMed:16254364, ECO:0000269\|PubMed:17360738, ECO:0000269\|PubMed:19324387, ECO:0000269\|PubMed:9851927}.
Q14137	BOP1	T106	ochoa	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein)	Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255\|HAMAP-Rule:MF_03027, ECO:0000269\|PubMed:17353269, ECO:0000269\|PubMed:24120868}.
Q14168	MPP2	T327	ochoa	MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2)	Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017). {ECO:0000250\|UniProtKB:D3ZAA9, ECO:0000250\|UniProtKB:Q9WV34, ECO:0000269\|PubMed:19665017}.
Q14324	MYBPC2	T849	ochoa	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Q14511	NEDD9	T184	ochoa	Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]	Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (PubMed:24574519). As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form (PubMed:9020138). Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs (PubMed:17174122). Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723). Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). {ECO:0000250\|UniProtKB:A0A8I3PDQ1, ECO:0000250\|UniProtKB:O35177, ECO:0000269\|PubMed:17174122, ECO:0000269\|PubMed:17604723, ECO:0000269\|PubMed:24574519, ECO:0000269\|PubMed:9020138}.
Q14524	SCN5A	T101	psp	Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)	Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:1309946, PubMed:21447824, PubMed:23085483, PubMed:23420830, PubMed:25370050, PubMed:26279430, PubMed:26392562, PubMed:26776555). Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed:11234013, PubMed:11804990, PubMed:12569159, PubMed:1309946). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). {ECO:0000250\|UniProtKB:Q9JJV9, ECO:0000269\|PubMed:11234013, ECO:0000269\|PubMed:11804990, ECO:0000269\|PubMed:12569159, ECO:0000269\|PubMed:1309946, ECO:0000269\|PubMed:19074138, ECO:0000269\|PubMed:21447824, ECO:0000269\|PubMed:23085483, ECO:0000269\|PubMed:23420830, ECO:0000269\|PubMed:24167619, ECO:0000269\|PubMed:25370050, ECO:0000269\|PubMed:26279430, ECO:0000269\|PubMed:26392562, ECO:0000269\|PubMed:26776555}.
Q14651	PLS1	T108	ochoa	Plastin-1 (Intestine-specific plastin) (I-plastin)	Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions. {ECO:0000250\|UniProtKB:Q3V0K9}.
Q14654	KCNJ11	T180	psp	ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)	Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells (PubMed:29286281, PubMed:34815345). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). In pancreatic cells, it forms KATP channels with ABCC8/SUR1 (PubMed:29286281, PubMed:34815345). Can form cardiac and smooth muscle-type KATP channels with ABCC9. {ECO:0000250, ECO:0000269\|PubMed:17855752, ECO:0000269\|PubMed:28842488, ECO:0000269\|PubMed:29286281, ECO:0000269\|PubMed:34815345, ECO:0000269\|PubMed:9831708}.
Q14676	MDC1	T847	psp	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)	Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269\|PubMed:12475977, ECO:0000269\|PubMed:12499369, ECO:0000269\|PubMed:12551934, ECO:0000269\|PubMed:12607003, ECO:0000269\|PubMed:12607004, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:12611903, ECO:0000269\|PubMed:14695167, ECO:0000269\|PubMed:15201865, ECO:0000269\|PubMed:15377652, ECO:0000269\|PubMed:16049003, ECO:0000269\|PubMed:16377563, ECO:0000269\|PubMed:18411307, ECO:0000269\|PubMed:18582474, ECO:0000269\|PubMed:18583988, ECO:0000269\|PubMed:18678890, ECO:0000269\|PubMed:30898438}.
Q14677	CLINT1	T270	ochoa	Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)	Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269\|PubMed:12429846, ECO:0000269\|PubMed:12538641}.
Q14680	MELK	T460	ochoa	Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269\|PubMed:11802789, ECO:0000269\|PubMed:12400006, ECO:0000269\|PubMed:14699119, ECO:0000269\|PubMed:15908796, ECO:0000269\|PubMed:16216881, ECO:0000269\|PubMed:17280616}.
Q14684	RRP1B	T693	psp	Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)	Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). {ECO:0000250\|UniProtKB:Q91YK2, ECO:0000269\|PubMed:19710015, ECO:0000269\|PubMed:20040599, ECO:0000269\|PubMed:20926688}.; FUNCTION: (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. {ECO:0000269\|PubMed:26311876}.
Q14687	GSE1	T1008	ochoa	Genetic suppressor element 1	None
Q14839	CHD4	T703	ochoa	Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)	ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250\|UniProtKB:Q6PDQ2, ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:17626165, ECO:0000269\|PubMed:25593309, ECO:0000269\|PubMed:28977666, ECO:0000269\|PubMed:32543371, ECO:0000269\|PubMed:9804427}.
Q14839	CHD4	T1679	ochoa	Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)	ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250\|UniProtKB:Q6PDQ2, ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:17626165, ECO:0000269\|PubMed:25593309, ECO:0000269\|PubMed:28977666, ECO:0000269\|PubMed:32543371, ECO:0000269\|PubMed:9804427}.
Q14978	NOLC1	T261	ochoa	Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269\|PubMed:10567578, ECO:0000269\|PubMed:26399832, ECO:0000269\|PubMed:9016786}.
Q14978	NOLC1	T597	ochoa	Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269\|PubMed:10567578, ECO:0000269\|PubMed:26399832, ECO:0000269\|PubMed:9016786}.
Q14980	NUMA1	T163	ochoa	Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)	Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074, PubMed:7769006). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:11956313, PubMed:12445386). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:22327364, PubMed:23027904, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24371089, PubMed:24996901). Also binds to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24371089, PubMed:24996901). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250\|UniProtKB:E9Q7G0, ECO:0000269\|PubMed:11163243, ECO:0000269\|PubMed:11229403, ECO:0000269\|PubMed:11956313, ECO:0000269\|PubMed:12445386, ECO:0000269\|PubMed:16076287, ECO:0000269\|PubMed:17172455, ECO:0000269\|PubMed:19255246, ECO:0000269\|PubMed:22327364, ECO:0000269\|PubMed:23027904, ECO:0000269\|PubMed:23870127, ECO:0000269\|PubMed:23921553, ECO:0000269\|PubMed:24109598, ECO:0000269\|PubMed:24371089, ECO:0000269\|PubMed:24996901, ECO:0000269\|PubMed:25657325, ECO:0000269\|PubMed:26195665, ECO:0000269\|PubMed:26765568, ECO:0000269\|PubMed:27462074, ECO:0000269\|PubMed:7769006, ECO:0000305\|PubMed:10075938, ECO:0000305\|PubMed:21816348}.
Q15014	MORF4L2	T91	ochoa	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX)	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Q15059	BRD3	T248	ochoa	Bromodomain-containing protein 3 (RING3-like protein)	Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250\|UniProtKB:Q8K2F0, ECO:0000269\|PubMed:18406326, ECO:0000269\|PubMed:22464331, ECO:0000269\|PubMed:27105114, ECO:0000269\|PubMed:29567837, ECO:0000269\|PubMed:32895492}.
Q15059	BRD3	T249	ochoa	Bromodomain-containing protein 3 (RING3-like protein)	Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250\|UniProtKB:Q8K2F0, ECO:0000269\|PubMed:18406326, ECO:0000269\|PubMed:22464331, ECO:0000269\|PubMed:27105114, ECO:0000269\|PubMed:29567837, ECO:0000269\|PubMed:32895492}.
Q15059	BRD3	T250	ochoa	Bromodomain-containing protein 3 (RING3-like protein)	Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250\|UniProtKB:Q8K2F0, ECO:0000269\|PubMed:18406326, ECO:0000269\|PubMed:22464331, ECO:0000269\|PubMed:27105114, ECO:0000269\|PubMed:29567837, ECO:0000269\|PubMed:32895492}.
Q15061	WDR43	T394	ochoa	WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)	Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250\|UniProtKB:Q6ZQL4, ECO:0000269\|PubMed:17699751, ECO:0000269\|PubMed:34516797}.
Q15124	PGM5	T120	ochoa	Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP)	Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905). {ECO:0000269\|PubMed:8175905}.
Q15208	STK38	T444	psp	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)	Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488). {ECO:0000269\|PubMed:12493777, ECO:0000269\|PubMed:15197186, ECO:0000269\|PubMed:17906693, ECO:0000269\|PubMed:32537488, ECO:0000269\|PubMed:7761441}.
Q15293	RCN1	T76	ochoa	Reticulocalbin-1	May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Q15365	PCBP1	T88	ochoa	Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)	Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250\|UniProtKB:P60335, ECO:0000269\|PubMed:15731341, ECO:0000269\|PubMed:7556077, ECO:0000269\|PubMed:7607214, ECO:0000269\|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269\|PubMed:12414943}.
Q15424	SAFB	T553	ochoa	Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein)	Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250\|UniProtKB:D3YXK2, ECO:0000269\|PubMed:12660241, ECO:0000269\|PubMed:9671816}.
Q15642	TRIP10	T225	psp	Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10)	Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269\|PubMed:11069762, ECO:0000269\|PubMed:16318909, ECO:0000269\|PubMed:16326391}.
Q15811	ITSN1	T1144	ochoa	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)	Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as a guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688). {ECO:0000250\|UniProtKB:Q9WVE9, ECO:0000250\|UniProtKB:Q9Z0R4, ECO:0000269\|PubMed:11584276, ECO:0000269\|PubMed:11744688, ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:29887380}.; FUNCTION: [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {ECO:0000250\|UniProtKB:Q9Z0R4}.
Q15831	STK11	T185	psp	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269\|PubMed:11430832, ECO:0000269\|PubMed:12805220, ECO:0000269\|PubMed:14517248, ECO:0000269\|PubMed:14976552, ECO:0000269\|PubMed:15016379, ECO:0000269\|PubMed:15733851, ECO:0000269\|PubMed:15987703, ECO:0000269\|PubMed:17108107, ECO:0000269\|PubMed:21317932, ECO:0000269\|PubMed:25329316}.; FUNCTION: [Isoform 2]: Has a role in spermiogenesis. {ECO:0000250}.
Q15835	GRK1	T492	psp	Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1)	Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). {ECO:0000250\|UniProtKB:Q9WVL4, ECO:0000269\|PubMed:15946941}.
Q15858	SCN9A	T103	ochoa	Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)	Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:17167479, PubMed:19369487, PubMed:24311784, PubMed:25240195, PubMed:26680203, PubMed:7720699). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (PubMed:17145499, PubMed:17167479, PubMed:19369487, PubMed:24311784). {ECO:0000269\|PubMed:15178348, ECO:0000269\|PubMed:15385606, ECO:0000269\|PubMed:16988069, ECO:0000269\|PubMed:17145499, ECO:0000269\|PubMed:17167479, ECO:0000269\|PubMed:19369487, ECO:0000269\|PubMed:24311784, ECO:0000269\|PubMed:25240195, ECO:0000269\|PubMed:26680203, ECO:0000269\|PubMed:7720699}.
Q15911	ZFHX3	T1582	ochoa	Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)	Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250\|UniProtKB:Q61329, ECO:0000269\|PubMed:11312261, ECO:0000269\|PubMed:17330845, ECO:0000269\|PubMed:20599712, ECO:0000269\|PubMed:20720010, ECO:0000269\|PubMed:25105025}.
Q16644	MAPKAPK3	T194	ochoa	MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)	Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. {ECO:0000269\|PubMed:10383393, ECO:0000269\|PubMed:15563468, ECO:0000269\|PubMed:18021073, ECO:0000269\|PubMed:20599781, ECO:0000269\|PubMed:8626550, ECO:0000269\|PubMed:8774846}.
Q16778	H2BC21	Y38	ochoa	Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Q16891	IMMT	T587	ochoa	MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89)	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180, PubMed:32567732, PubMed:33130824). {ECO:0000269\|PubMed:22114354, ECO:0000269\|PubMed:25781180, ECO:0000269\|PubMed:32567732, ECO:0000269\|PubMed:33130824}.
Q29RF7	PDS5A	T1227	ochoa	Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112)	Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269\|PubMed:15855230, ECO:0000269\|PubMed:19907496}.
Q2KHR3	QSER1	T949	ochoa	Glutamine and serine-rich protein 1	Plays an essential role in the protection and maintenance of transcriptional and developmental programs. Protects many bivalent promoters and poised enhancers from hypermethylation, showing a marked preference for these regulatory elements over other types of promoters or enhancers. Mechanistically, cooperates with TET1 and binds to DNA in a common complex to inhibit the binding of DNMT3A/3B and therefore de novo methylation. {ECO:0000269\|PubMed:33833093}.
Q2LD37	BLTP1	T3849	ochoa	Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein)	Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269\|PubMed:30906834, ECO:0000269\|PubMed:31540829, ECO:0000305\|PubMed:35015055, ECO:0000305\|PubMed:35491307}.
Q2NKX8	ERCC6L	T813	ochoa	DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)	DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269\|PubMed:17218258, ECO:0000269\|PubMed:23973328, ECO:0000269\|PubMed:28977671}.
Q3V6T2	CCDC88A	T1535	ochoa	Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)	Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250\|UniProtKB:Q5SNZ0, ECO:0000269\|PubMed:15882442, ECO:0000269\|PubMed:16139227, ECO:0000269\|PubMed:19211784, ECO:0000269\|PubMed:20462955, ECO:0000269\|PubMed:21954290, ECO:0000269\|PubMed:23509302, ECO:0000269\|PubMed:25187647, ECO:0000269\|PubMed:27621449, ECO:0000269\|PubMed:27623382}.
Q4VCS5	AMOT	T1061	ochoa	Angiomotin	Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866). {ECO:0000269\|PubMed:11257124, ECO:0000269\|PubMed:16678097, ECO:0000269\|PubMed:21205866}.
Q52LW3	ARHGAP29	T22	ochoa	Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. {ECO:0000269\|PubMed:15752761, ECO:0000269\|PubMed:9305890}.
Q53EZ4	CEP55	T39	ochoa	Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6)	Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). {ECO:0000269\|PubMed:16198290, ECO:0000269\|PubMed:17853893, ECO:0000269\|PubMed:28264986}.
Q562F6	SGO2	T1084	ochoa	Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin)	Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250, ECO:0000269\|PubMed:16541025, ECO:0000269\|PubMed:17485487, ECO:0000269\|PubMed:20739936}.
Q5FBB7	SGO1	T425	ochoa	Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1)	Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269\|PubMed:15604152, ECO:0000269\|PubMed:15723797, ECO:0000269\|PubMed:15737064, ECO:0000269\|PubMed:16580887, ECO:0000269\|PubMed:17617734, ECO:0000269\|PubMed:17621308, ECO:0000269\|PubMed:18331714, ECO:0000269\|PubMed:20739936}.
Q5JSH3	WDR44	T271	ochoa	WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11)	Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269\|PubMed:31204173, ECO:0000269\|PubMed:32344433}.
Q5JSH3	WDR44	T880	ochoa	WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11)	Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269\|PubMed:31204173, ECO:0000269\|PubMed:32344433}.
Q5JSL3	DOCK11	T1352	ochoa	Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)	Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957). {ECO:0000250\|UniProtKB:A2AF47, ECO:0000269\|PubMed:37342957}.
Q5JSP0	FGD3	T549	ochoa	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5)	Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q5M775	SPECC1	T205	ochoa	Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1)	None
Q5QJE6	DNTTIP2	T307	ochoa	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269\|PubMed:12786946, ECO:0000269\|PubMed:15047147, ECO:0000269\|PubMed:34516797}.
Q5QJE6	DNTTIP2	T610	ochoa	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269\|PubMed:12786946, ECO:0000269\|PubMed:15047147, ECO:0000269\|PubMed:34516797}.
Q5QNW6	H2BC18	Y38	ochoa	Histone H2B type 2-F (H2B-clustered histone 18)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q5RI15	COX20	T27	ochoa	Cytochrome c oxidase assembly protein COX20, mitochondrial	Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284). Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053). {ECO:0000269\|PubMed:23125284, ECO:0000269\|PubMed:24403053}.
Q5S007	LRRK2	T1357	psp	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269\|PubMed:17114044, ECO:0000269\|PubMed:18230735, ECO:0000269\|PubMed:20949042, ECO:0000269\|PubMed:21850687, ECO:0000269\|PubMed:22012985, ECO:0000269\|PubMed:23395371, ECO:0000269\|PubMed:24687852, ECO:0000269\|PubMed:25201882, ECO:0000269\|PubMed:26014385, ECO:0000269\|PubMed:26824392, ECO:0000269\|PubMed:27830463, ECO:0000269\|PubMed:28720718, ECO:0000269\|PubMed:29125462, ECO:0000269\|PubMed:29127255, ECO:0000269\|PubMed:29212815, ECO:0000269\|PubMed:30209220, ECO:0000269\|PubMed:30398148, ECO:0000269\|PubMed:30635421, ECO:0000269\|PubMed:38127736, ECO:0000269\|PubMed:38227290}.
Q5S007	LRRK2	T1368	psp	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269\|PubMed:17114044, ECO:0000269\|PubMed:18230735, ECO:0000269\|PubMed:20949042, ECO:0000269\|PubMed:21850687, ECO:0000269\|PubMed:22012985, ECO:0000269\|PubMed:23395371, ECO:0000269\|PubMed:24687852, ECO:0000269\|PubMed:25201882, ECO:0000269\|PubMed:26014385, ECO:0000269\|PubMed:26824392, ECO:0000269\|PubMed:27830463, ECO:0000269\|PubMed:28720718, ECO:0000269\|PubMed:29125462, ECO:0000269\|PubMed:29127255, ECO:0000269\|PubMed:29212815, ECO:0000269\|PubMed:30209220, ECO:0000269\|PubMed:30398148, ECO:0000269\|PubMed:30635421, ECO:0000269\|PubMed:38127736, ECO:0000269\|PubMed:38227290}.
Q5SW79	CEP170	T682	ochoa	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.
Q5SYE7	NHSL1	T581	ochoa	NHS-like protein 1	None
Q5T200	ZC3H13	T1037	ochoa	Zinc finger CCCH domain-containing protein 13	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250\|UniProtKB:E9Q784}.
Q5VYS8	TUT7	T64	ochoa	Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6)	Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250\|UniProtKB:Q5BLK4, ECO:0000269\|PubMed:18172165, ECO:0000269\|PubMed:19703396, ECO:0000269\|PubMed:22898984, ECO:0000269\|PubMed:25480299, ECO:0000269\|PubMed:25979828, ECO:0000269\|PubMed:28671666, ECO:0000269\|PubMed:30122351}.
Q63HK5	TSHZ3	T431	ochoa	Teashirt homolog 3 (Zinc finger protein 537)	Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250\|UniProtKB:Q8CGV9, ECO:0000269\|PubMed:19343227}.
Q63HK5	TSHZ3	T451	ochoa	Teashirt homolog 3 (Zinc finger protein 537)	Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250\|UniProtKB:Q8CGV9, ECO:0000269\|PubMed:19343227}.
Q641Q2	WASHC2A	T331	ochoa	WASH complex subunit 2A	Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269\|PubMed:25355947, ECO:0000269\|PubMed:28892079}.
Q641Q2	WASHC2A	T479	ochoa	WASH complex subunit 2A	Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269\|PubMed:25355947, ECO:0000269\|PubMed:28892079}.
Q641Q2	WASHC2A	T533	ochoa	WASH complex subunit 2A	Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269\|PubMed:25355947, ECO:0000269\|PubMed:28892079}.
Q68CP9	ARID2	T1726	ochoa	AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269\|PubMed:16782067, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
Q68DQ2	CRYBG3	T231	ochoa	Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3)	[Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269\|PubMed:25097019}.
Q6DN03	H2BC20P	Y38	ochoa	Putative histone H2B type 2-C (H2B-clustered histone 20 pseudogene) (Histone H2B.t) (H2B/t)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q6DN90	IQSEC1	T362	ochoa	IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2)	Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (By similarity). {ECO:0000250\|UniProtKB:A0A0G2JUG7, ECO:0000269\|PubMed:11226253, ECO:0000269\|PubMed:16461286, ECO:0000269\|PubMed:24058294, ECO:0000305\|PubMed:31607425}.
Q6DRA6	H2BC19P	Y38	ochoa	Putative histone H2B type 2-D (H2B-clustered histone 19 pseudogene)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q6FHJ7	SFRP4	T189	psp	Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927). {ECO:0000250\|UniProtKB:Q9JLS4, ECO:0000250\|UniProtKB:Q9Z1N6, ECO:0000269\|PubMed:12952927}.
Q6N022	TENM4	T2581	ochoa	Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4)	Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250\|UniProtKB:Q3UHK6, ECO:0000269\|PubMed:26188006}.
Q6NZY4	ZCCHC8	T652	ochoa	Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8)	Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing (Probable). It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579). {ECO:0000269\|PubMed:27871484, ECO:0000269\|PubMed:31488579, ECO:0000305\|PubMed:16263084}.
Q6P0N0	MIS18BP1	T698	ochoa	Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243)	Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269\|PubMed:17199038, ECO:0000269\|PubMed:17339379}.
Q6P0N0	MIS18BP1	T993	ochoa	Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243)	Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269\|PubMed:17199038, ECO:0000269\|PubMed:17339379}.
Q6P0N0	MIS18BP1	T1087	ochoa	Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243)	Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269\|PubMed:17199038, ECO:0000269\|PubMed:17339379}.
Q6P0N0	MIS18BP1	T1089	ochoa	Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243)	Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269\|PubMed:17199038, ECO:0000269\|PubMed:17339379}.
Q6P0Q8	MAST2	T82	ochoa	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
Q6P1Q9	METTL2B	T152	ochoa	tRNA N(3)-cytidine methyltransferase METTL2B (EC 2.1.1.-) (Methyltransferase-like protein 2B)	S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). {ECO:0000269\|PubMed:28655767}.
Q6P2H3	CEP85	T35	ochoa	Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21)	Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269\|PubMed:26220856, ECO:0000269\|PubMed:29712910, ECO:0000269\|PubMed:32107292}.
Q6P4F7	ARHGAP11A	T306	ochoa	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269\|PubMed:27957544}.
Q6P4F7	ARHGAP11A	T508	ochoa	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269\|PubMed:27957544}.
Q6P4R8	NFRKB	T498	ochoa	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G)	Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269\|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269\|PubMed:18922472}.
Q6P4R8	NFRKB	T1035	ochoa	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G)	Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269\|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269\|PubMed:18922472}.
Q6P995	FAM171B	T404	ochoa	Protein FAM171B	None
Q6PCE3	PGM2L1	T173	ochoa	Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1)	Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate, as acceptors (PubMed:17804405). In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant (PubMed:17804405). {ECO:0000269\|PubMed:17804405, ECO:0000269\|PubMed:18927083, ECO:0000269\|PubMed:33979636}.
Q6PD62	CTR9	T975	ochoa	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250\|UniProtKB:Q62018, ECO:0000269\|PubMed:16024656, ECO:0000269\|PubMed:16307923, ECO:0000269\|PubMed:19345177, ECO:0000269\|PubMed:19952111, ECO:0000269\|PubMed:20178742, ECO:0000269\|PubMed:20541477, ECO:0000269\|PubMed:21329879}.
Q6PL18	ATAD2	T1158	ochoa	ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA)	May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269\|PubMed:17998543}.
Q6UB98	ANKRD12	T1011	ochoa	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein)	May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
Q6UB99	ANKRD11	T1419	ochoa	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)	Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250\|UniProtKB:E9Q4F7, ECO:0000269\|PubMed:15184363, ECO:0000269\|PubMed:25556659}.
Q6VY07	PACS1	T488	ochoa	Phosphofurin acidic cluster sorting protein 1 (PACS-1)	Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250\|UniProtKB:Q8K212, ECO:0000269\|PubMed:11331585, ECO:0000269\|PubMed:15692563}.
Q6W2J9	BCOR	T1147	ochoa	BCL-6 corepressor (BCoR)	Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269\|PubMed:10898795, ECO:0000269\|PubMed:15004558, ECO:0000269\|PubMed:18280243, ECO:0000269\|PubMed:19578371, ECO:0000269\|PubMed:23911289}.
Q6WKZ4	RAB11FIP1	T188	ochoa	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein)	A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269\|PubMed:11786538, ECO:0000269\|PubMed:15181150, ECO:0000269\|PubMed:15355514, ECO:0000269\|PubMed:16920206, ECO:0000269\|PubMed:26032412}.
Q6WKZ4	RAB11FIP1	T1198	ochoa	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein)	A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269\|PubMed:11786538, ECO:0000269\|PubMed:15181150, ECO:0000269\|PubMed:15355514, ECO:0000269\|PubMed:16920206, ECO:0000269\|PubMed:26032412}.
Q6ZUM4	ARHGAP27	T680	ochoa	Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20)	Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.
Q6ZV73	FGD6	T693	ochoa	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)	May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q6ZWE6	PLEKHM3	T102	ochoa	Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) (Differentiation associated protein)	Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. {ECO:0000250\|UniProtKB:Q8BM47}.
Q702N8	XIRP1	T139	ochoa	Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1)	Protects actin filaments from depolymerization (PubMed:15454575). Required for correct cardiac intercalated disk ultrastructure via maintenance of cell-cell adhesion stability, and as a result maintains cardiac organ morphology, conductance and heart beat rhythm (By similarity). Required for development of normal skeletal muscle morphology and muscle fiber type composition (By similarity). Plays a role in regulating muscle satellite cell activation and survival, as a result promotes muscle fiber recovery from injury and fatigue (By similarity). {ECO:0000250\|UniProtKB:O70373, ECO:0000269\|PubMed:15454575}.
Q70CQ2	USP34	T3383	ochoa	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34)	Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. {ECO:0000269\|PubMed:21383061}.
Q71F56	MED13L	T779	ochoa	Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Q76I76	SSH2	T779	ochoa	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L)	Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250\|UniProtKB:Q5SW75, ECO:0000269\|PubMed:11832213}.
Q7KZF4	SND1	T103	ochoa\|psp	Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)	Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250\|UniProtKB:Q78PY7, ECO:0000269\|PubMed:12234934, ECO:0000269\|PubMed:18453631, ECO:0000269\|PubMed:28546213, ECO:0000269\|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269\|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269\|PubMed:37794589}.
Q7KZF4	SND1	T418	ochoa	Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)	Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250\|UniProtKB:Q78PY7, ECO:0000269\|PubMed:12234934, ECO:0000269\|PubMed:18453631, ECO:0000269\|PubMed:28546213, ECO:0000269\|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269\|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269\|PubMed:37794589}.
Q7L0Y3	TRMT10C	T81	ochoa	tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221)	Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269\|PubMed:18984158, ECO:0000269\|PubMed:21593607, ECO:0000269\|PubMed:23042678, ECO:0000269\|PubMed:24703694, ECO:0000269\|PubMed:27132592, ECO:0000269\|PubMed:29040705, ECO:0000269\|PubMed:29072297}.
Q7L2J0	MEPCE	T243	ochoa	7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog)	S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269\|PubMed:17643375, ECO:0000269\|PubMed:19906723, ECO:0000269\|PubMed:28254838, ECO:0000269\|PubMed:30559425, ECO:0000269\|PubMed:38100593}.
Q7L576	CYFIP1	T1234	ochoa	Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)	Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. {ECO:0000250\|UniProtKB:Q7TMB8, ECO:0000269\|PubMed:16260607, ECO:0000269\|PubMed:19524508, ECO:0000269\|PubMed:21107423, ECO:0000269\|PubMed:9417078}.
Q7Z2W9	MRPL21	T188	ochoa	Large ribosomal subunit protein bL21m (39S ribosomal protein L21, mitochondrial) (L21mt) (MRP-L21)	None
Q7Z3J3	RGPD4	T1475	ochoa	RanBP2-like and GRIP domain-containing protein 4	None
Q7Z3K3	POGZ	T1368	ochoa	Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635)	Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). {ECO:0000269\|PubMed:20562864, ECO:0000269\|PubMed:26721387}.
Q7Z3S7	CACNA2D4	T505	ochoa	Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4]	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269\|PubMed:12181424}.
Q7Z5N4	SDK1	T2129	ochoa	Protein sidekick-1	Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. {ECO:0000250\|UniProtKB:Q8AV58}.
Q7Z5U6	WDR53	T307	ochoa	WD repeat-containing protein 53	None
Q7Z6E9	RBBP6	T1264	ochoa	E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)	E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250\|UniProtKB:P97868, ECO:0000269\|PubMed:18851979, ECO:0000269\|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269\|PubMed:30550789}.
Q86TI0	TBC1D1	T652	ochoa	TBC1 domain family member 1	May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.
Q86UP3	ZFHX4	T2808	ochoa	Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4)	May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation. {ECO:0000250}.
Q86UR5	RIMS1	T1407	ochoa	Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)	Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250\|UniProtKB:Q99NE5, ECO:0000269\|PubMed:23999003}.
Q86X27	RALGPS2	T361	ochoa	Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)	Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.
Q86X53	ERICH1	T56	ochoa	Glutamate-rich protein 1	None
Q86YP4	GATAD2A	T586	ochoa	Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A)	Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269\|PubMed:12183469, ECO:0000269\|PubMed:16415179, ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:28977666}.
Q86YV5	PRAG1	T386	ochoa	Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)	Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). {ECO:0000250\|UniProtKB:D3ZMK9, ECO:0000250\|UniProtKB:Q571I4}.
Q8IVF7	FMNL3	T95	ochoa	Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)	Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. {ECO:0000250\|UniProtKB:Q6NXC0, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:22275430}.
Q8IVL0	NAV3	T1193	ochoa	Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3)	Plays a role in cell migration (PubMed:21471154). May be involved in neuron regeneration. May regulate IL2 production by T-cells. {ECO:0000269\|PubMed:16166283, ECO:0000269\|PubMed:21471154}.
Q8IVL1	NAV2	T1881	ochoa	Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)	Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269\|PubMed:12214280, ECO:0000269\|PubMed:15158073}.
Q8IWZ3	ANKHD1	T1653	ochoa	Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK)	May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269\|PubMed:16098192}.
Q8IX12	CCAR1	T627	ochoa	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)	Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250\|UniProtKB:Q8CH18, ECO:0000269\|PubMed:12816952, ECO:0000269\|PubMed:23887938, ECO:0000269\|PubMed:24245781}.
Q8IX18	DHX40	T50	ochoa	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.4.13) (DEAH box protein 40) (Protein PAD)	Probable ATP-dependent RNA helicase. {ECO:0000250}.
Q8IYD8	FANCM	T1759	ochoa	Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog)	DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269\|PubMed:16116422, ECO:0000269\|PubMed:16116434, ECO:0000269\|PubMed:17289582, ECO:0000269\|PubMed:19423727, ECO:0000269\|PubMed:20347428, ECO:0000269\|PubMed:20347429, ECO:0000269\|PubMed:29231814}.
Q8IZP1	TBC1D3	T165	psp	TBC1 domain family member 3 (Prostate cancer gene 17 protein) (Protein TRE17-alpha) (Rab GTPase-activating protein PRC17)	Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. {ECO:0000269\|PubMed:12359748}.
Q8IZT6	ASPM	T647	ochoa	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)	Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269\|PubMed:12355089, ECO:0000269\|PubMed:15972725, ECO:0000269\|PubMed:28436967}.
Q8N0Z3	SPICE1	T318	ochoa	Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein)	Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269\|PubMed:20736305}.
Q8N257	H2BC26	Y38	ochoa	Histone H2B type 3-B (H2B type 12) (H2B-clustered histone 26) (H2B.U histone 1)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q8N302	AGGF1	T337	ochoa	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (hVG5Q) (G patch domain-containing protein 7) (Vasculogenesis gene on 5q protein)	Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269\|PubMed:14961121}.
Q8N328	PGBD3	T93	ochoa	PiggyBac transposable element-derived protein 3	Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269\|PubMed:22483866}.
Q8N392	ARHGAP18	T260	ochoa	Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)	Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). {ECO:0000269\|PubMed:21865595, ECO:0000269\|PubMed:25778702}.
Q8N3K9	CMYA5	T201	ochoa	Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76)	May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:Q70KF4}.
Q8N3X1	FNBP4	T662	ochoa	Formin-binding protein 4 (Formin-binding protein 30)	None
Q8N7H5	PAF1	T116	ochoa	RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro. {ECO:0000269\|PubMed:16491129, ECO:0000269\|PubMed:19410543, ECO:0000269\|PubMed:19952111, ECO:0000269\|PubMed:20178742, ECO:0000269\|PubMed:20541477, ECO:0000269\|PubMed:21329879, ECO:0000269\|PubMed:22419161}.
Q8N806	UBR7	T235	ochoa	Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7)	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. {ECO:0000250}.
Q8ND71	GIMAP8	T557	ochoa	GTPase IMAP family member 8 (Immune-associated nucleotide-binding protein 9) (IAN-9) (Protein IanT)	Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. {ECO:0000250\|UniProtKB:Q75N62}.
Q8ND83	SLAIN1	T204	ochoa	SLAIN motif-containing protein 1	Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation. {ECO:0000269\|PubMed:21646404}.
Q8NER1	TRPV1	T705	psp	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)	Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli (PubMed:11050376, PubMed:11243859, PubMed:11226139, PubMed:12077606). Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius (PubMed:37117175). Upon activation, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. {ECO:0000250\|UniProtKB:O35433, ECO:0000269\|PubMed:11050376, ECO:0000269\|PubMed:11226139, ECO:0000269\|PubMed:11243859, ECO:0000269\|PubMed:12077606, ECO:0000269\|PubMed:37117175}.
Q8NEU8	APPL2	T399	ochoa	DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)	Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:15016378, PubMed:24879834, PubMed:26583432). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (By similarity) (PubMed:24879834). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negatively regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (By similarity) (PubMed:19433865). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250\|UniProtKB:Q8K3G9, ECO:0000269\|PubMed:15016378, ECO:0000269\|PubMed:19433865, ECO:0000269\|PubMed:24879834, ECO:0000269\|PubMed:26583432}.
Q8NEY1	NAV1	T138	ochoa	Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1)	May be involved in neuronal migration. {ECO:0000250}.
Q8NEZ4	KMT2C	T2851	ochoa	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:24081332, ECO:0000269\|PubMed:25561738}.
Q8NEZ4	KMT2C	T3693	ochoa	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:24081332, ECO:0000269\|PubMed:25561738}.
Q8NFA0	USP32	T1401	ochoa	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32)	Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874). {ECO:0000269\|PubMed:36476874}.
Q8NFC6	BOD1L1	T1354	ochoa	Biorientation of chromosomes in cell division protein 1-like 1	Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269\|PubMed:26166705, ECO:0000269\|PubMed:29937342}.
Q8NG31	KNL1	T1017	ochoa	Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14)	Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250\|UniProtKB:Q66JQ7, ECO:0000269\|PubMed:15502821, ECO:0000269\|PubMed:17981135, ECO:0000269\|PubMed:18045986, ECO:0000269\|PubMed:19893618, ECO:0000269\|PubMed:21199919, ECO:0000269\|PubMed:22000412, ECO:0000269\|PubMed:22331848, ECO:0000269\|PubMed:25308863, ECO:0000269\|PubMed:27881301, ECO:0000269\|PubMed:30100357, ECO:0000269\|PubMed:38459127, ECO:0000269\|PubMed:38459128}.
Q8NHQ9	DDX55	T141	ochoa	ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55)	Probable ATP-binding RNA helicase. Has ATPase activity and is involved in the maturation of precursor large subunit rRNAs (PubMed:33048000). {ECO:0000269\|PubMed:33048000}.
Q8NHV4	NEDD1	T401	ochoa\|psp	Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1)	Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269\|PubMed:19029337, ECO:0000269\|PubMed:19509060}.
Q8NHW5	RPLP0P6	T144	ochoa	Putative ribosomal protein uL10-like (60S acidic ribosomal protein P0-like) (Large ribosomal subunit protein uL10-like)	Ribosomal protein P0 is the functional equivalent of E.coli protein L10. {ECO:0000250}.
Q8NI27	THOC2	T1285	ochoa	THO complex subunit 2 (Tho2) (hTREX120)	Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. {ECO:0000269\|PubMed:11979277, ECO:0000269\|PubMed:15833825, ECO:0000269\|PubMed:15998806, ECO:0000269\|PubMed:17190602, ECO:0000269\|PubMed:22893130, ECO:0000269\|PubMed:23222130, ECO:0000269\|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269\|PubMed:18974867}.
Q8TD26	CHD6	T205	ochoa	Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.-) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)	ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. {ECO:0000269\|PubMed:16314513, ECO:0000269\|PubMed:17027977, ECO:0000269\|PubMed:28533432}.; FUNCTION: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. {ECO:0000269\|PubMed:20631145, ECO:0000269\|PubMed:21899694, ECO:0000269\|PubMed:23408615}.
Q8TDM6	DLG5	T842	ochoa	Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)	Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). {ECO:0000250\|UniProtKB:E9Q9R9, ECO:0000269\|PubMed:28087714, ECO:0000269\|PubMed:28169360}.
Q8TEJ3	SH3RF3	T383	ochoa	E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)	Has E3 ubiquitin-protein ligase activity. {ECO:0000269\|PubMed:20696164}.
Q8TEW0	PARD3	T1147	ochoa	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250\|UniProtKB:Q99NH2, ECO:0000250\|UniProtKB:Q9Z340, ECO:0000269\|PubMed:10934474, ECO:0000269\|PubMed:10954424, ECO:0000269\|PubMed:19812038, ECO:0000269\|PubMed:27925688}.
Q8WVC0	LEO1	T496	ochoa	RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. {ECO:0000269\|PubMed:15632063, ECO:0000269\|PubMed:15791002, ECO:0000269\|PubMed:19345177, ECO:0000269\|PubMed:19952111, ECO:0000269\|PubMed:20178742}.
Q8WW12	PCNP	T139	ochoa	PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein)	May be involved in cell cycle regulation.
Q8WWK9	CKAP2	T579	ochoa\|psp	Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein)	Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.
Q8WWL7	CCNB3	T666	ochoa	G2/mitotic-specific cyclin-B3	Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. {ECO:0000269\|PubMed:12185076}.
Q8WWY3	PRPF31	T440	ochoa	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31)	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:20118938, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543). {ECO:0000269\|PubMed:11867543, ECO:0000269\|PubMed:20118938, ECO:0000269\|PubMed:28781166}.
Q8WXE9	STON2	T766	ochoa	Stonin-2 (Stoned B)	Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269\|PubMed:11381094, ECO:0000269\|PubMed:11454741, ECO:0000269\|PubMed:21102408}.
Q8WXH0	SYNE2	T5862	ochoa	Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:34818527). Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 (PubMed:34818527). {ECO:0000250\|UniProtKB:Q6ZWQ0, ECO:0000269\|PubMed:12118075, ECO:0000269\|PubMed:18396275, ECO:0000269\|PubMed:19596800, ECO:0000269\|PubMed:20724637, ECO:0000269\|PubMed:22945352, ECO:0000269\|PubMed:34818527}.
Q8WXI7	MUC16	T774	ochoa	Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125)	Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
Q8WY36	BBX	T809	ochoa	HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2)	Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269\|PubMed:11680820}.
Q8WYP5	AHCTF1	T1349	ochoa	Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)	Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269\|PubMed:17098863, ECO:0000269\|PubMed:17235358}.
Q92575	UBXN4	T489	ochoa	UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)	Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269\|PubMed:16968747, ECO:0000269\|PubMed:19822669}.
Q92576	PHF3	T158	ochoa	PHD finger protein 3	None
Q92794	KAT6A	T1144	ochoa	Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)	Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269\|PubMed:11742995, ECO:0000269\|PubMed:11965546, ECO:0000269\|PubMed:12771199, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:17925393, ECO:0000269\|PubMed:23431171}.
Q92830	KAT2A	T735	psp	Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)	Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase, succinyltransferase or malonyltransferase, depending on the context (PubMed:29211711, PubMed:35995428). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755, PubMed:21131905). Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac) (PubMed:21131905). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (PubMed:29973595, PubMed:31527837). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (By similarity). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (By similarity). Regulates embryonic stem cell (ESC) pluripotency and differentiation (By similarity). Also acetylates non-histone proteins, such as CEBPB, MRE11, PPARGC1A, PLK4 and TBX5 (PubMed:16753578, PubMed:17301242, PubMed:27796307, PubMed:29174768, PubMed:38128537). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Acts as a negative regulator of gluconeogenesis by mediating acetylation and subsequent inactivation of PPARGC1A (PubMed:16753578, PubMed:23142079). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). {ECO:0000250\|UniProtKB:Q9JHD2, ECO:0000269\|PubMed:16753578, ECO:0000269\|PubMed:17301242, ECO:0000269\|PubMed:19103755, ECO:0000269\|PubMed:21131905, ECO:0000269\|PubMed:23142079, ECO:0000269\|PubMed:27796307, ECO:0000269\|PubMed:29174768, ECO:0000269\|PubMed:29211711, ECO:0000269\|PubMed:29973595, ECO:0000269\|PubMed:31527837, ECO:0000269\|PubMed:31542297, ECO:0000269\|PubMed:35995428, ECO:0000269\|PubMed:38128537}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. {ECO:0000269\|PubMed:11384967}.
Q92844	TANK	T175	ochoa	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269\|PubMed:12133833, ECO:0000269\|PubMed:21931631, ECO:0000269\|PubMed:25861989}.
Q92900	UPF1	T151	psp	Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1)	RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (PubMed:11163187, PubMed:16086026, PubMed:18172165, PubMed:21145460, PubMed:21419344, PubMed:24726324). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD (PubMed:11544179, PubMed:25220460). Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex (PubMed:19417104). In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD (PubMed:21419344). Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors (PubMed:12554878). UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways (PubMed:18447585). Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2 (PubMed:16086026, PubMed:18172165). For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585, PubMed:25220460). The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD (PubMed:21145460). Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA harboring long 3'UTR by inducing the NMD machinery (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (PubMed:30218034). {ECO:0000250\|UniProtKB:Q9EPU0, ECO:0000269\|PubMed:11163187, ECO:0000269\|PubMed:11544179, ECO:0000269\|PubMed:12554878, ECO:0000269\|PubMed:16086026, ECO:0000269\|PubMed:18172165, ECO:0000269\|PubMed:18447585, ECO:0000269\|PubMed:19417104, ECO:0000269\|PubMed:21145460, ECO:0000269\|PubMed:21419344, ECO:0000269\|PubMed:24726324, ECO:0000269\|PubMed:25220460, ECO:0000269\|PubMed:30218034}.
Q93079	H2BC9	Y38	ochoa	Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q93100	PHKB	T702	ochoa	Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)	Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.
Q969P6	TOP1MT	T421	ochoa	DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1)	Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11526219}.
Q96A22	C11orf52	T30	ochoa	Uncharacterized protein C11orf52	None
Q96B97	SH3KBP1	T252	ochoa	SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)	Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269\|PubMed:11894095, ECO:0000269\|PubMed:11894096, ECO:0000269\|PubMed:12177062, ECO:0000269\|PubMed:12734385, ECO:0000269\|PubMed:12771190, ECO:0000269\|PubMed:15090612, ECO:0000269\|PubMed:15707590, ECO:0000269\|PubMed:16177060, ECO:0000269\|PubMed:16256071, ECO:0000269\|PubMed:21275903, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:29636373}.
Q96BD5	PHF21A	T176	ochoa	PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)	Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269\|PubMed:16140033}.
Q96BK5	PINX1	T141	psp	PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)	Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269\|PubMed:15381700, ECO:0000269\|PubMed:17198684, ECO:0000269\|PubMed:19117989, ECO:0000269\|PubMed:19265708, ECO:0000269\|PubMed:19393617, ECO:0000269\|PubMed:19553660}.
Q96BY6	DOCK10	T1406	ochoa	Dedicator of cytokinesis protein 10 (Zizimin-3)	Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250\|UniProtKB:Q8BZN6}.
Q96CB8	INTS12	T357	ochoa	Integrator complex subunit 12 (Int12) (PHD finger protein 22)	Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269\|PubMed:16239144, ECO:0000269\|PubMed:23904267, ECO:0000269\|PubMed:38570683}.
Q96CC6	RHBDF1	T347	ochoa	Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho)	Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269\|PubMed:15965977, ECO:0000269\|PubMed:18524845, ECO:0000269\|PubMed:18832597, ECO:0000269\|PubMed:21439629}.
Q96EP5	DAZAP1	T21	ochoa	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1)	RNA-binding protein, which may be required during spermatogenesis.
Q96GX5	MASTL	T710	ochoa	Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)	Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269\|PubMed:12890928, ECO:0000269\|PubMed:19680222, ECO:0000269\|PubMed:19793917, ECO:0000269\|PubMed:20538976, ECO:0000269\|PubMed:20818157, ECO:0000269\|PubMed:38123684}.
Q96HE9	PRR11	T311	ochoa	Proline-rich protein 11	Plays a critical role in cell cycle progression. {ECO:0000269\|PubMed:23246489}.
Q96HE9	PRR11	T326	ochoa	Proline-rich protein 11	Plays a critical role in cell cycle progression. {ECO:0000269\|PubMed:23246489}.
Q96IY1	NSL1	T241	ochoa	Kinetochore-associated protein NSL1 homolog	Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. {ECO:0000269\|PubMed:16585270}.
Q96IZ0	PAWR	T163	ochoa\|psp	PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4)	Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269\|PubMed:11585763}.
Q96J84	KIRREL1	T549	ochoa	Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)	Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269\|PubMed:31472902}.
Q96KB5	PBK	T26	ochoa	Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)	Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269\|PubMed:10781613, ECO:0000269\|PubMed:17482142}.
Q96LT9	RNPC3	T291	ochoa	RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K)	Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. {ECO:0000269\|PubMed:16096647, ECO:0000269\|PubMed:19447915, ECO:0000269\|PubMed:24480542, ECO:0000269\|PubMed:29255062}.
Q96N46	TTC14	T543	ochoa	Tetratricopeptide repeat protein 14 (TPR repeat protein 14)	None
Q96N67	DOCK7	T1385	ochoa	Dedicator of cytokinesis protein 7	Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250\|UniProtKB:Q8R1A4, ECO:0000269\|PubMed:16982419, ECO:0000269\|PubMed:29467281}.
Q96NC0	ZMAT2	T71	ochoa	Zinc finger matrin-type protein 2	Involved in pre-mRNA splicing as a component of the spliceosome. {ECO:0000269\|PubMed:28781166}.
Q96PC5	MIA2	T1118	ochoa	Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11)	Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250\|UniProtKB:Q91ZV0, ECO:0000269\|PubMed:21525241, ECO:0000269\|PubMed:25202031, ECO:0000269\|PubMed:27138255, ECO:0000269\|PubMed:27170179}.
Q96Q89	KIF20B	T1644	ochoa\|psp	Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1)	Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250\|UniProtKB:Q80WE4, ECO:0000269\|PubMed:11470801, ECO:0000269\|PubMed:12740395, ECO:0000269\|PubMed:17409436}.
Q96QT4	TRPM7	T1830	psp	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]	Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250\|UniProtKB:Q923J1, ECO:0000269\|PubMed:11385574, ECO:0000269\|PubMed:12887921, ECO:0000269\|PubMed:15485879, ECO:0000269\|PubMed:18365021, ECO:0000269\|PubMed:18394644, ECO:0000269\|PubMed:24316671, ECO:0000269\|PubMed:35561741, ECO:0000269\|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250\|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250\|UniProtKB:Q923J1}.
Q96RT1	ERBIN	T648	ochoa	Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269\|PubMed:10878805, ECO:0000269\|PubMed:16203728}.
Q96S66	CLCC1	T482	ochoa	Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein)	Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250\|UniProtKB:Q99LI2, ECO:0000269\|PubMed:25698737, ECO:0000269\|PubMed:30157172, ECO:0000269\|PubMed:37142673}.
Q96T23	RSF1	T1388	ochoa	Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex)	Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269\|PubMed:11788598, ECO:0000269\|PubMed:11944984, ECO:0000269\|PubMed:12972596, ECO:0000269\|PubMed:28801535}.
Q96T58	SPEN	T894	ochoa	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250\|UniProtKB:Q62504, ECO:0000269\|PubMed:11331609, ECO:0000269\|PubMed:12374742}.
Q96T58	SPEN	T1826	ochoa	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250\|UniProtKB:Q62504, ECO:0000269\|PubMed:11331609, ECO:0000269\|PubMed:12374742}.
Q96T58	SPEN	T2921	ochoa	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250\|UniProtKB:Q62504, ECO:0000269\|PubMed:11331609, ECO:0000269\|PubMed:12374742}.
Q99460	PSMD1	T367	ochoa	26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269\|PubMed:1317798}.
Q99569	PKP4	T1013	ochoa	Plakophilin-4 (p0071)	Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269\|PubMed:17115030}.
Q99570	PIK3R4	T927	ochoa	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269\|PubMed:20643123}.
Q99666	RGPD5	T1474	ochoa	RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)	None
Q99729	HNRNPAB	T80	ochoa	Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)	Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
Q99741	CDC6	T37	psp	Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)	Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Q99741	CDC6	T43	ochoa	Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)	Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Q99741	CDC6	T67	ochoa	Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)	Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Q99832	CCT7	T57	psp	T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269\|PubMed:25467444, ECO:0000269\|PubMed:35449234, ECO:0000269\|PubMed:36493755, ECO:0000269\|PubMed:37193829}.
Q99877	H2BC15	Y38	ochoa	Histone H2B type 1-N (Histone H2B.d) (H2B/d)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q99879	H2BC14	Y38	ochoa	Histone H2B type 1-M (Histone H2B.e) (H2B/e)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q99880	H2BC13	Y38	ochoa	Histone H2B type 1-L (Histone H2B.c) (H2B/c)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q99956	DUSP9	T237	ochoa	Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)	Inactivates MAP kinases. Has a specificity for the ERK family.
Q9BPU6	DPYSL5	T514	ochoa	Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6)	Involved in the negative regulation of dendrite outgrowth. {ECO:0000269\|PubMed:33894126}.
Q9BQG0	MYBBP1A	T1161	ochoa	Myb-binding protein 1A	May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250\|UniProtKB:Q7TPV4, ECO:0000269\|PubMed:29065309}.
Q9BQG0	MYBBP1A	T1190	ochoa	Myb-binding protein 1A	May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250\|UniProtKB:Q7TPV4, ECO:0000269\|PubMed:29065309}.
Q9BRY0	SLC39A3	T120	ochoa	Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3)	Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen. {ECO:0000250\|UniProtKB:Q99K24}.
Q9BSJ8	ESYT1	T824	ochoa	Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)	Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250\|UniProtKB:A0FGR8, ECO:0000269\|PubMed:23791178, ECO:0000269\|PubMed:24183667, ECO:0000269\|PubMed:38758649}.
Q9BTC0	DIDO1	T151	ochoa	Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)	Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269\|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269\|PubMed:16127461}.
Q9BTC0	DIDO1	T580	ochoa	Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)	Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269\|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269\|PubMed:16127461}.
Q9BUK6	MSTO1	T150	ochoa	Protein misato homolog 1	Involved in the regulation of mitochondrial distribution and morphology (PubMed:17349998, PubMed:28544275, PubMed:28554942). Required for mitochondrial fusion and mitochondrial network formation (PubMed:28544275, PubMed:28554942). {ECO:0000269\|PubMed:17349998, ECO:0000269\|PubMed:28544275, ECO:0000269\|PubMed:28554942}.
Q9BW04	SARG	T379	ochoa	Specifically androgen-regulated gene protein	Putative androgen-specific receptor. {ECO:0000269\|PubMed:15525603}.
Q9BWN1	PRR14	T266	ochoa	Proline-rich protein 14	Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). {ECO:0000269\|PubMed:24209742, ECO:0000269\|PubMed:25906157, ECO:0000269\|PubMed:27041574}.
Q9BX63	BRIP1	T1062	ochoa	Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ)	DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269\|PubMed:11301010, ECO:0000269\|PubMed:14983014, ECO:0000269\|PubMed:16116421, ECO:0000269\|PubMed:16153896, ECO:0000269\|PubMed:17596542, ECO:0000269\|PubMed:18426915, ECO:0000269\|PubMed:20639400, ECO:0000269\|PubMed:36608669}.
Q9BX66	SORBS1	T370	ochoa	Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)	Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250\|UniProtKB:Q62417}.
Q9BXS6	NUSAP1	T314	ochoa	Nucleolar and spindle-associated protein 1 (NuSAP)	Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269\|PubMed:12963707}.
Q9BY11	PACSIN1	T332	ochoa	Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)	Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269\|PubMed:19549836, ECO:0000269\|PubMed:22573331, ECO:0000269\|PubMed:23236520}.
Q9BYB0	SHANK3	T349	ochoa	SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)	Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269\|PubMed:24132240}.
Q9BYG3	NIFK	T223	ochoa	MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)	None
Q9BYX2	TBC1D2	T430	ochoa	TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)	Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion. {ECO:0000269\|PubMed:20116244}.
Q9GZL7	WDR12	T221	ochoa	Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)	Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255\|HAMAP-Rule:MF_03029, ECO:0000269\|PubMed:16043514, ECO:0000269\|PubMed:17353269}.
Q9GZR1	SENP6	T416	ochoa	Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)	Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269\|PubMed:16912044, ECO:0000269\|PubMed:17000875, ECO:0000269\|PubMed:18799455, ECO:0000269\|PubMed:20212317, ECO:0000269\|PubMed:20705237, ECO:0000269\|PubMed:21148299}.
Q9GZX5	ZNF350	T283	ochoa	Zinc finger protein 350 (KRAB zinc finger protein ZFQR) (Zinc finger and BRCA1-interacting protein with a KRAB domain 1) (Zinc finger protein ZBRK1)	Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3. {ECO:0000269\|PubMed:11090615}.
Q9H089	LSG1	T626	ochoa	Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-)	Functions as a GTPase (PubMed:16209721). May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation (PubMed:31148378). {ECO:0000269\|PubMed:16209721, ECO:0000269\|PubMed:31148378}.
Q9H0D6	XRN2	T433	ochoa	5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)	Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269\|PubMed:15565158, ECO:0000269\|PubMed:16648491, ECO:0000269\|PubMed:21700224}.
Q9H1H9	KIF13A	T1385	ochoa	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN)	Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269\|PubMed:19841138, ECO:0000269\|PubMed:20208530}.
Q9H2G2	SLK	T1097	ochoa	STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)	Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}.
Q9H2G9	BLZF1	T331	ochoa	Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor)	Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. {ECO:0000269\|PubMed:11739401}.
Q9H2K8	TAOK3	T745	ochoa	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3)	Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250\|UniProtKB:Q8BYC6, ECO:0000269\|PubMed:10559204, ECO:0000269\|PubMed:10924369, ECO:0000269\|PubMed:17396146, ECO:0000269\|PubMed:30373850, ECO:0000269\|PubMed:32807497, ECO:0000269\|PubMed:34634521, ECO:0000269\|PubMed:38166031}.
Q9H4G0	EPB41L1	T799	ochoa	Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N)	May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9H4M9	EHD1	T479	ochoa	EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)	ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250\|UniProtKB:Q641Z6, ECO:0000250\|UniProtKB:Q9WVK4, ECO:0000269\|PubMed:15020713, ECO:0000269\|PubMed:17233914, ECO:0000269\|PubMed:20801876, ECO:0000269\|PubMed:24019528, ECO:0000269\|PubMed:25686250, ECO:0000269\|PubMed:31615969}.
Q9H7Z3	NRDE2	T211	ochoa	Nuclear exosome regulator NRDE2 (Protein NRDE2 homolog)	Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117). {ECO:0000269\|PubMed:29902117, ECO:0000269\|PubMed:30538148, ECO:0000269\|PubMed:30842217}.
Q9H8E8	KAT14	T286	ochoa	Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14)	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. {ECO:0000269\|PubMed:19103755}.
Q9H8V3	ECT2	T373	ochoa\|psp	Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)	Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269\|PubMed:10579713, ECO:0000269\|PubMed:14645260, ECO:0000269\|PubMed:15254234, ECO:0000269\|PubMed:15545273, ECO:0000269\|PubMed:15642749, ECO:0000269\|PubMed:16103226, ECO:0000269\|PubMed:16170345, ECO:0000269\|PubMed:16236794, ECO:0000269\|PubMed:16495035, ECO:0000269\|PubMed:19129481, ECO:0000269\|PubMed:19468300, ECO:0000269\|PubMed:19617897, ECO:0000269\|PubMed:21189248, ECO:0000269\|PubMed:21373644, ECO:0000269\|PubMed:25068414, ECO:0000269\|PubMed:31888991}.
Q9H8V3	ECT2	T444	psp	Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)	Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269\|PubMed:10579713, ECO:0000269\|PubMed:14645260, ECO:0000269\|PubMed:15254234, ECO:0000269\|PubMed:15545273, ECO:0000269\|PubMed:15642749, ECO:0000269\|PubMed:16103226, ECO:0000269\|PubMed:16170345, ECO:0000269\|PubMed:16236794, ECO:0000269\|PubMed:16495035, ECO:0000269\|PubMed:19129481, ECO:0000269\|PubMed:19468300, ECO:0000269\|PubMed:19617897, ECO:0000269\|PubMed:21189248, ECO:0000269\|PubMed:21373644, ECO:0000269\|PubMed:25068414, ECO:0000269\|PubMed:31888991}.
Q9H8V3	ECT2	T846	psp	Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)	Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269\|PubMed:10579713, ECO:0000269\|PubMed:14645260, ECO:0000269\|PubMed:15254234, ECO:0000269\|PubMed:15545273, ECO:0000269\|PubMed:15642749, ECO:0000269\|PubMed:16103226, ECO:0000269\|PubMed:16170345, ECO:0000269\|PubMed:16236794, ECO:0000269\|PubMed:16495035, ECO:0000269\|PubMed:19129481, ECO:0000269\|PubMed:19468300, ECO:0000269\|PubMed:19617897, ECO:0000269\|PubMed:21189248, ECO:0000269\|PubMed:21373644, ECO:0000269\|PubMed:25068414, ECO:0000269\|PubMed:31888991}.
Q9H8Y8	GORASP2	T222	ochoa\|psp	Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59)	Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250\|UniProtKB:Q99JX3, ECO:0000269\|PubMed:10487747, ECO:0000269\|PubMed:11101516, ECO:0000269\|PubMed:21515684, ECO:0000269\|PubMed:21884936, ECO:0000269\|PubMed:22523075, ECO:0000269\|PubMed:27062250, ECO:0000269\|PubMed:28067262}.
Q9H910	JPT2	T100	ochoa	Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein)	Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269\|PubMed:33758061, ECO:0000269\|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269\|PubMed:33758061}.
Q9HAU0	PLEKHA5	T476	ochoa	Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)	None
Q9HAW0	BRF2	T377	ochoa	Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU)	General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269\|PubMed:11040218, ECO:0000269\|PubMed:11121026, ECO:0000269\|PubMed:11564744, ECO:0000269\|PubMed:26638071}.
Q9HC44	GPBP1L1	T178	ochoa	Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1)	Possible transcription factor. {ECO:0000305}.
Q9HCK8	CHD8	T209	ochoa	Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)	ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255\|HAMAP-Rule:MF_03071, ECO:0000269\|PubMed:17938208, ECO:0000269\|PubMed:18378692, ECO:0000269\|PubMed:28533432, ECO:0000269\|PubMed:36537238}.
Q9NP64	ZCCHC17	T132	ochoa	Zinc finger CCHC domain-containing protein 17 (Nucleolar protein of 40 kDa) (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein)	None
Q9NP79	VTA1	T150	ochoa	Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1)	Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. {ECO:0000250, ECO:0000269\|PubMed:15644320}.
Q9NQ25	SLAMF7	T306	ochoa	SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319)	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528). {ECO:0000250\|UniProtKB:Q8BHK6, ECO:0000269\|PubMed:11698418, ECO:0000269\|PubMed:11802771, ECO:0000269\|PubMed:16339536, ECO:0000269\|PubMed:23695528, ECO:0000269\|Ref.4}.; FUNCTION: Isoform 3 does not mediate any NK cell activation.
Q9NR30	DDX21	T296	ochoa	Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)	RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250\|UniProtKB:Q9JIK5, ECO:0000269\|PubMed:11823437, ECO:0000269\|PubMed:14559904, ECO:0000269\|PubMed:18180292, ECO:0000269\|PubMed:25260534, ECO:0000269\|PubMed:25470060, ECO:0000269\|PubMed:25477391, ECO:0000269\|PubMed:28431233, ECO:0000269\|PubMed:28790157, ECO:0000269\|PubMed:9461305}.
Q9NR30	DDX21	T569	ochoa	Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)	RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). {ECO:0000250\|UniProtKB:Q9JIK5, ECO:0000269\|PubMed:11823437, ECO:0000269\|PubMed:14559904, ECO:0000269\|PubMed:18180292, ECO:0000269\|PubMed:25260534, ECO:0000269\|PubMed:25470060, ECO:0000269\|PubMed:25477391, ECO:0000269\|PubMed:28431233, ECO:0000269\|PubMed:28790157, ECO:0000269\|PubMed:9461305}.
Q9NRL2	BAZ1A	T1059	ochoa	Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1)	Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269\|PubMed:12434153, ECO:0000269\|PubMed:14759371, ECO:0000269\|PubMed:17099699, ECO:0000269\|PubMed:17519354, ECO:0000269\|PubMed:28801535}.
Q9NSI2	SLX9	T138	ochoa	Ribosome biogenesis protein SLX9 homolog	May be involved in ribosome biogenesis. {ECO:0000250\|UniProtKB:P53251}.
Q9NTI7	INKA2	T265	ochoa	PAK4-inhibitor INKA2 (Induced in neural crest by AP2-alpha protein-related homolog) (Inca-r) (Inka-box actin regulator 2)	Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity. {ECO:0000250\|UniProtKB:Q96EL1}.
Q9NUL3	STAU2	T408	ochoa	Double-stranded RNA-binding protein Staufen homolog 2	RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). {ECO:0000250\|UniProtKB:Q68SB1}.
Q9NUQ6	SPATS2L	T393	ochoa	SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP)	None
Q9NUY8	TBC1D23	T514	ochoa	TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1)	Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250\|UniProtKB:Q8K0F1, ECO:0000269\|PubMed:28823707, ECO:0000269\|PubMed:29084197, ECO:0000269\|PubMed:29426865}.
Q9NVR5	DNAAF2	T705	ochoa	Protein kintoun (Dynein assembly factor 2, axonemal)	Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. {ECO:0000255\|HAMAP-Rule:MF_03069}.
Q9NWH9	SLTM	T345	ochoa	SAFB-like transcription modulator (Modulator of estrogen-induced transcription)	When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9NXL9	MCM9	T1110	ochoa	DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9)	Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250\|UniProtKB:Q2KHI9, ECO:0000269\|PubMed:23401855, ECO:0000269\|PubMed:26215093, ECO:0000269\|PubMed:26300262}.
Q9NYV4	CDK12	T514	ochoa	Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269\|PubMed:11683387, ECO:0000269\|PubMed:19651820, ECO:0000269\|PubMed:20952539, ECO:0000269\|PubMed:22012619, ECO:0000269\|PubMed:24662513}.
Q9NYV4	CDK12	T1244	ochoa	Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269\|PubMed:11683387, ECO:0000269\|PubMed:19651820, ECO:0000269\|PubMed:20952539, ECO:0000269\|PubMed:22012619, ECO:0000269\|PubMed:24662513}.
Q9NZ45	CISD1	T88	ochoa	CDGSH iron-sulfur domain-containing protein 1 (Cysteine transaminase CISD1) (EC 2.6.1.3) (MitoNEET)	L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (PubMed:36194135). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (PubMed:36194135). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (PubMed:17584744, PubMed:21788481, PubMed:23758282). {ECO:0000250, ECO:0000250\|UniProtKB:Q91WS0, ECO:0000269\|PubMed:17584744, ECO:0000269\|PubMed:17766440, ECO:0000269\|PubMed:21788481, ECO:0000269\|PubMed:23758282, ECO:0000269\|PubMed:36194135}.
Q9NZL9	MAT2B	T309	ochoa	Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase)	Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). {ECO:0000269\|PubMed:10644686, ECO:0000269\|PubMed:23189196, ECO:0000269\|PubMed:23425511, ECO:0000269\|PubMed:25075345}.
Q9NZM1	MYOF	T1103	ochoa	Myoferlin (Fer-1-like protein 3)	Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}.
Q9NZM3	ITSN2	T1123	ochoa	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)	Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269\|PubMed:19458185, ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:23999003}.
Q9P2J5	LARS1	T293	psp	Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)	Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) (PubMed:25051973, PubMed:32232361). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA (PubMed:25051973). To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) (PubMed:25051973). {ECO:0000269\|PubMed:19426743, ECO:0000269\|PubMed:25051973, ECO:0000269\|PubMed:32232361}.
Q9P2N5	RBM27	T796	ochoa	RNA-binding protein 27 (RNA-binding motif protein 27)	May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000269\|PubMed:31950173}.
Q9P2Y5	UVRAG	T553	ochoa	UV radiation resistance-associated gene protein (p63)	Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300). {ECO:0000269\|PubMed:18552835, ECO:0000269\|PubMed:20643123, ECO:0000269\|PubMed:24056303, ECO:0000269\|PubMed:28306502, ECO:0000305}.; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840). {ECO:0000269\|PubMed:22542840}.
Q9UBC2	EPS15L1	T674	ochoa	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:9407958}.
Q9UDY2	TJP2	T707	ochoa	Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2)	Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250\|UniProtKB:Q9Z0U1}.
Q9UGP8	SEC63	T537	ochoa	Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23)	Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250\|UniProtKB:Q8VHE0, ECO:0000269\|PubMed:22375059, ECO:0000269\|PubMed:29719251}.
Q9UGU0	TCF20	T1520	ochoa	Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)	Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. {ECO:0000269\|PubMed:10995766}.
Q9UHD1	CHORDC1	T48	ochoa	Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)	Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269\|PubMed:20230755, ECO:0000269\|PubMed:32053105}.
Q9UHF7	TRPS1	T751	ochoa	Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79)	Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269\|PubMed:12885770, ECO:0000269\|PubMed:17391059}.
Q9UHG3	PCYOX1	T402	ochoa	Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase)	Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:10585463). {ECO:0000250\|UniProtKB:F1N2K1, ECO:0000269\|PubMed:10585463, ECO:0000269\|PubMed:11078725, ECO:0000269\|PubMed:12186880}.
Q9UHR4	BAIAP2L1	T248	ochoa	BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)	May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269\|PubMed:17430976, ECO:0000269\|PubMed:19366662, ECO:0000269\|PubMed:22921828}.
Q9UHV7	MED13	T2049	ochoa	Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:16595664}.
Q9UHX3	ADGRE2	T801	ochoa	Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312)	Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). {ECO:0000269\|PubMed:12829604, ECO:0000269\|PubMed:17928360, ECO:0000269\|PubMed:22310662, ECO:0000269\|PubMed:22575658, ECO:0000269\|PubMed:26841242}.
Q9UIF8	BAZ2B	T2014	ochoa	Bromodomain adjacent to zinc finger domain protein 2B (hWALp4)	Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250\|UniProtKB:A2AUY4, ECO:0000269\|PubMed:28801535, ECO:0000303\|PubMed:10662543}.
Q9UKD1	GMEB2	T346	ochoa	Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79)	Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Q9UKJ3	GPATCH8	T1115	ochoa	G patch domain-containing protein 8	None
Q9UKK9	NUDT5	T43	ochoa	ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H)	Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:17052728, PubMed:19699693, PubMed:21389046). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). {ECO:0000250\|UniProtKB:Q9JKX6, ECO:0000269\|PubMed:10567213, ECO:0000269\|PubMed:10722730, ECO:0000269\|PubMed:17052728, ECO:0000269\|PubMed:19699693, ECO:0000269\|PubMed:21389046, ECO:0000269\|PubMed:27257257}.
Q9UKL3	CASP8AP2	T565	ochoa	CASP8-associated protein 2 (FLICE-associated huge protein)	Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269\|PubMed:12477726, ECO:0000269\|PubMed:15698540, ECO:0000269\|PubMed:17003125, ECO:0000269\|PubMed:17245429}.
Q9UKX2	MYH2	T69	ochoa	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250\|UniProtKB:P12883}.
Q9UKX7	NUP50	T259	ochoa	Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)	Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250\|UniProtKB:Q9JIH2, ECO:0000269\|PubMed:20016008}.
Q9UKY1	ZHX1	T568	ochoa\|psp	Zinc fingers and homeoboxes protein 1	Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269\|PubMed:12237128}.
Q9ULD2	MTUS1	T800	ochoa	Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1)	Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269\|PubMed:12692079, ECO:0000269\|PubMed:19794912}.
Q9ULD2	MTUS1	T1204	ochoa	Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1)	Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269\|PubMed:12692079, ECO:0000269\|PubMed:19794912}.
Q9ULH0	KIDINS220	T1682	ochoa	Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)	Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269\|PubMed:18089783}.
Q9ULH1	ASAP1	T906	ochoa	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)	Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269\|PubMed:20393563, ECO:0000269\|PubMed:25673879}.
Q9ULH1	ASAP1	T1048	ochoa	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)	Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269\|PubMed:20393563, ECO:0000269\|PubMed:25673879}.
Q9ULJ7	ANKRD50	T1198	ochoa	Ankyrin repeat domain-containing protein 50	Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).
Q9ULW0	TPX2	T323	ochoa	Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)	Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). {ECO:0000269\|PubMed:18663142, ECO:0000269\|PubMed:19208764, ECO:0000269\|PubMed:26165940}.
Q9UMR3	TBX20	T316	ochoa	T-box transcription factor TBX20 (T-box protein 20)	Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. {ECO:0000250}.
Q9UNF0	PACSIN2	T391	ochoa	Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)	Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250\|UniProtKB:Q9WVE8, ECO:0000269\|PubMed:21693584, ECO:0000269\|PubMed:23129763, ECO:0000269\|PubMed:23236520, ECO:0000269\|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269\|PubMed:29891700, ECO:0000269\|PubMed:31242077, ECO:0000269\|PubMed:31801866}.
Q9UPT9	USP22	T147	ochoa	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)	Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. As part of the transcription regulatory histone acetylation (HAT) complex SAGA, catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a transcriptional coactivator (PubMed:18206972, PubMed:18206973, PubMed:18469533). Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Facilitates cell-cycle progression by stabilizing CCNB1 and antagonizing its proteasome-mediated degradation in a cell cycle-specific manner (PubMed:27030811). Modulates cell cycle progression and apoptosis also by antagonizing TP53 transcriptional activation through deacetylase SIRT1 stabilization (PubMed:22542455). Plays multiple roles in immunity and inflammation. Participates in antiviral response by deubiquitinating the importin KPNA2, leading to IRF3 nuclear translocation and subsequent type I interferon production (PubMed:32130408). Acts as a central regulator of type III IFN signaling by negatively regulating STING1 activation and ubiquitination (PubMed:35933402). Inhibits NLRP3 inflammasome activation by promoting NLRP3 degradation through ATG5-dependent autophagy (By similarity). Deubiquitinates CD274 to induce its stabilization and thereby participates in maintenance of immune tolerance to self (PubMed:31399419). Controls necroptotic cell death by regulating RIPK3 phosphorylation and ubiquitination (PubMed:33369872). During bacterial infection, promotes pro-inflammatory response by targeting TRAF6 and removing its 'Lys-48'-linked polyubiquitination (By similarity). {ECO:0000250\|UniProtKB:Q5DU02, ECO:0000269\|PubMed:18206972, ECO:0000269\|PubMed:18206973, ECO:0000269\|PubMed:18469533, ECO:0000269\|PubMed:22542455, ECO:0000269\|PubMed:27030811, ECO:0000269\|PubMed:31399419, ECO:0000269\|PubMed:32130408, ECO:0000269\|PubMed:33369872, ECO:0000269\|PubMed:35933402}.
Q9UPU7	TBC1D2B	T551	ochoa	TBC1 domain family member 2B	GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269\|PubMed:32623794}.
Q9UPW0	FOXJ3	T65	ochoa	Forkhead box protein J3	Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). {ECO:0000250\|UniProtKB:Q8BUR3}.
Q9UQ35	SRRM2	T111	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQB8	BAIAP2	T360	ochoa\|psp	BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)	Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269\|PubMed:11130076, ECO:0000269\|PubMed:11696321, ECO:0000269\|PubMed:14752106, ECO:0000269\|PubMed:17115031, ECO:0000269\|PubMed:19366662}.
Q9UQM7	CAMK2A	T310	ochoa	Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250\|UniProtKB:P11275, ECO:0000250\|UniProtKB:P11798, ECO:0000269\|PubMed:11972023, ECO:0000269\|PubMed:23805378, ECO:0000269\|PubMed:28130356, ECO:0000269\|PubMed:29100089}.
Q9Y2H1	STK38L	T442	psp	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2)	Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250, ECO:0000269\|PubMed:15037617, ECO:0000269\|PubMed:15067004}.
Q9Y2L6	FRMD4B	T529	ochoa	FERM domain-containing protein 4B (GRP1-binding protein GRSP1)	Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250\|UniProtKB:Q920B0}.
Q9Y2M0	FAN1	T110	ochoa	Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15)	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866). {ECO:0000269\|PubMed:20603015, ECO:0000269\|PubMed:20603016, ECO:0000269\|PubMed:20603073, ECO:0000269\|PubMed:20671156, ECO:0000269\|PubMed:24981866, ECO:0000269\|PubMed:25135477, ECO:0000269\|PubMed:25430771}.
Q9Y2U5	MAP3K2	T516	ochoa	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)	Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269\|PubMed:10713157, ECO:0000269\|PubMed:16001074}.
Q9Y2W1	THRAP3	T381	ochoa	Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)	Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269\|PubMed:20123736, ECO:0000269\|PubMed:20932480, ECO:0000269\|PubMed:22424773, ECO:0000269\|PubMed:23525231, ECO:0000269\|PubMed:24043798}.
Q9Y2W1	THRAP3	T397	ochoa	Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)	Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269\|PubMed:20123736, ECO:0000269\|PubMed:20932480, ECO:0000269\|PubMed:22424773, ECO:0000269\|PubMed:23525231, ECO:0000269\|PubMed:24043798}.
Q9Y2X0	MED16	T571	ochoa	Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) (Thyroid hormone receptor-associated protein 5) (Thyroid hormone receptor-associated protein complex 95 kDa component) (Trap95) (Vitamin D3 receptor-interacting protein complex 92 kDa component) (DRIP92)	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:10198638, ECO:0000269\|PubMed:10235266}.
Q9Y314	NOSIP	T30	ochoa	Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase NOSIP) (eNOS-interacting protein)	E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). {ECO:0000250\|UniProtKB:Q9D6T0, ECO:0000269\|PubMed:11149895, ECO:0000269\|PubMed:15548660, ECO:0000269\|PubMed:16135813}.
Q9Y315	DERA	T292	ochoa	Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. {ECO:0000269\|PubMed:25229427}.
Q9Y3A5	SBDS	T77	ochoa	Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein)	Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. {ECO:0000269\|PubMed:17643419, ECO:0000269\|PubMed:19602484, ECO:0000269\|PubMed:19759903, ECO:0000269\|PubMed:21536732}.
Q9Y3C8	UFC1	T118	ochoa	Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1)	E2-like enzyme which specifically catalyzes the second step in ufmylation (PubMed:15071506, PubMed:29868776, PubMed:30626644, PubMed:34588452, PubMed:35394863, PubMed:36121123, PubMed:38383789). Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage (PubMed:15071506, PubMed:29868776, PubMed:34588452, PubMed:38383789). Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:27351204, PubMed:32160526, PubMed:35394863, PubMed:37036982, PubMed:38383789). {ECO:0000269\|PubMed:15071506, ECO:0000269\|PubMed:27351204, ECO:0000269\|PubMed:29868776, ECO:0000269\|PubMed:30626644, ECO:0000269\|PubMed:32160526, ECO:0000269\|PubMed:34588452, ECO:0000269\|PubMed:35394863, ECO:0000269\|PubMed:36121123, ECO:0000269\|PubMed:37036982, ECO:0000269\|PubMed:38383789}.
Q9Y4F3	MARF1	T714	ochoa	Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1)	Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}.
Q9Y4J8	DTNA	T687	ochoa	Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3)	May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Q9Y520	PRRC2C	T25	ochoa	Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)	Required for efficient formation of stress granules. {ECO:0000269\|PubMed:29395067}.
Q9Y623	MYH4	T69	ochoa	Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)	Muscle contraction.
Q9Y623	MYH4	T758	ochoa	Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)	Muscle contraction.
Q9Y6A5	TACC3	T87	ochoa	Transforming acidic coiled-coil-containing protein 3 (ERIC-1)	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250\|UniProtKB:Q9JJ11, ECO:0000269\|PubMed:14767476, ECO:0000269\|PubMed:21297582, ECO:0000269\|PubMed:23532825}.
Q9Y6X8	ZHX2	T207	ochoa	Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2)	Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity). {ECO:0000250\|UniProtKB:Q8C0C0, ECO:0000269\|PubMed:12741956}.
R4GMW8	BIVM-ERCC5	T792	ochoa	DNA excision repair protein ERCC-5	None
U3KPZ7	LOC127814297	T741	ochoa	RNA-binding protein 27 (RNA-binding motif protein 27)	May be involved in the turnover of nuclear polyadenylated (pA+) RNA. {ECO:0000256\|ARBA:ARBA00043866}.
P26641	EEF1G	T287	Sugiyama	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)	Probably plays a role in anchoring the complex to other cellular components.
P23528	CFL1	T63	Sugiyama	Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)	Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250\|UniProtKB:P18760, ECO:0000269\|PubMed:11812157, ECO:0000269\|PubMed:15580268, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:23633677}.
P48643	CCT5	T269	Sugiyama	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000269\|PubMed:35449234, ECO:0000269\|PubMed:36493755, ECO:0000269\|PubMed:37193829}.
P11142	HSPA8	T66	Sugiyama	Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250\|UniProtKB:P19120, ECO:0000269\|PubMed:10722728, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:11559757, ECO:0000269\|PubMed:12526792, ECO:0000269\|PubMed:15894275, ECO:0000269\|PubMed:21148293, ECO:0000269\|PubMed:21150129, ECO:0000269\|PubMed:23018488, ECO:0000269\|PubMed:23990462, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24732912, ECO:0000269\|PubMed:27474739, ECO:0000269\|PubMed:27916661, ECO:0000269\|PubMed:2799391, ECO:0000269\|PubMed:36586411, ECO:0000303\|PubMed:24121476, ECO:0000303\|PubMed:26865365}.
P22314	UBA1	T1016	Sugiyama	Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269\|PubMed:1447181, ECO:0000269\|PubMed:1606621, ECO:0000269\|PubMed:22456334, ECO:0000269\|PubMed:33108101}.
P38646	HSPA9	T116	Sugiyama	Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)	Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250\|UniProtKB:P0CS90, ECO:0000250\|UniProtKB:P38647, ECO:0000269\|PubMed:16091382, ECO:0000269\|PubMed:18632665, ECO:0000269\|PubMed:21123823, ECO:0000269\|PubMed:24625977, ECO:0000269\|PubMed:25615450, ECO:0000269\|PubMed:26634371, ECO:0000269\|PubMed:26702583, ECO:0000269\|PubMed:28848044, ECO:0000269\|PubMed:30933555, ECO:0000269\|PubMed:31177526}.
P62917	RPL8	T135	Sugiyama	Large ribosomal subunit protein uL2 (60S ribosomal protein L8)	Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547, ECO:0000305\|PubMed:12962325}.
P14314	PRKCSH	T469	Sugiyama	Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH)	Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250\|UniProtKB:O08795, ECO:0000269\|PubMed:10929008}.
P07195	LDHB	T276	Sugiyama	L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)	Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269\|PubMed:27618187}.
P27797	CALR	T34	Sugiyama	Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)	Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250\|UniProtKB:P28491, ECO:0000250\|UniProtKB:Q8K3H7, ECO:0000269\|PubMed:11149926, ECO:0000269\|PubMed:7876246}.
P30086	PEBP1	T167	Sugiyama	Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]	Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269\|PubMed:18294816}.; FUNCTION: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.
P31949	S100A11	T33	Sugiyama	Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]	Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269\|PubMed:18618420}.
P50991	CCT4	T69	Sugiyama	T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding)	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000269\|PubMed:35449234, ECO:0000269\|PubMed:36493755, ECO:0000269\|PubMed:37193829}.
P62899	RPL31	T22	Sugiyama	Large ribosomal subunit protein eL31 (60S ribosomal protein L31)	Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547}.
Q02878	RPL6	T118	Sugiyama	Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107)	Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:25901680, ECO:0000269\|PubMed:25957688, ECO:0000269\|PubMed:32669547, ECO:0000305\|PubMed:12962325}.; FUNCTION: (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). {ECO:0000269\|PubMed:8457378}.
Q07020	RPL18	T79	Sugiyama	Large ribosomal subunit protein eL18 (60S ribosomal protein L18)	Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:25901680, ECO:0000269\|PubMed:25957688, ECO:0000269\|PubMed:32669547, ECO:0000305\|PubMed:12962325}.
Q15293	RCN1	T144	Sugiyama	Reticulocalbin-1	May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Q9H173	SIL1	T125	Sugiyama	Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP)	Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269\|PubMed:12356756}.
A0A2R8Y4L2	HNRNPA1L3	T25	Sugiyama	Heterogeneous nuclear ribonucleoprotein A1-like 3 (Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48)	None
P09651	HNRNPA1	T25	Sugiyama	Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]	Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269\|PubMed:17371836, ECO:0000269\|PubMed:20010808, ECO:0000269\|PubMed:28431233, ECO:0000269\|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269\|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269\|PubMed:17229681}.
P84098	RPL19	T56	EPSD\|PSP	Large ribosomal subunit protein eL19 (60S ribosomal protein L19)	Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547}.
Q32P51	HNRNPA1L2	T25	Sugiyama	Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2)	Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. {ECO:0000250}.
Q9Y696	CLIC4	T222	Sugiyama	Chloride intracellular channel protein 4 (Glutaredoxin-like oxidoreductase CLIC4) (EC 1.8.-.-) (Intracellular chloride ion channel protein p64H1)	In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250\|UniProtKB:Q9Z0W7, ECO:0000269\|PubMed:12163372, ECO:0000269\|PubMed:14569596, ECO:0000269\|PubMed:16176272, ECO:0000269\|PubMed:16239224, ECO:0000269\|PubMed:18302930, ECO:0000269\|PubMed:19247789, ECO:0000269\|PubMed:25581026, ECO:0000269\|PubMed:37759794}.
O43852	CALU	T89	Sugiyama	Calumenin (Crocalbin) (IEF SSP 9302)	Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}.
O14556	GAPDHS	T301	Sugiyama	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase)	May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). {ECO:0000250}.
P23284	PPIB	T81	Sugiyama	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269\|PubMed:20676357}.
O43615	TIMM44	T198	Sugiyama	Mitochondrial import inner membrane translocase subunit TIM44	Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity). {ECO:0000250\|UniProtKB:O35857, ECO:0000250\|UniProtKB:Q01852}.
P55060	CSE1L	T341	Sugiyama	Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)	Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269\|PubMed:9323134}.
Q9HC38	GLOD4	T249	Sugiyama	Glyoxalase domain-containing protein 4	None
P10636	MAPT	T470	EPSD	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269\|PubMed:21985311, ECO:0000269\|PubMed:32961270}.
O43283	MAP3K13	T32	Sugiyama	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)	Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269\|PubMed:11726277, ECO:0000269\|PubMed:12492477, ECO:0000269\|PubMed:9353328}.
P23284	PPIB	T108	Sugiyama	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. {ECO:0000269\|PubMed:20676357}.
Q9UMX5	NENF	T130	Sugiyama	Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein)	Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Also acts as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). {ECO:0000250\|UniProtKB:Q9CQ45, ECO:0000269\|PubMed:31536960}.
P11586	MTHFD1	T380	Sugiyama	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]	Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269\|PubMed:10828945, ECO:0000269\|PubMed:18767138, ECO:0000269\|PubMed:1881876, ECO:0000269\|PubMed:25633902}.
Q86UK7	ZNF598	T857	Sugiyama	E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)	E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:32099016, PubMed:32579943, PubMed:33581075). ZNF598 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28065601, PubMed:28132843, PubMed:28685749). Acts as a ribosome collision sensor: specifically recognizes and binds collided di-ribosome, which arises when a trailing ribosome encounters a slower leading ribosome, leading to terminally arrest translation (PubMed:28065601, PubMed:28132843, PubMed:28685749, PubMed:30293783). Following binding to colliding ribosomes, mediates monoubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS3/uS3, and 'Lys-63'-linked polyubiquitination of RPS20/uS10 (PubMed:28065601, PubMed:28132843, PubMed:28685749). Polyubiquitination of RPS20/uS10 promotes recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:32099016, PubMed:32579943, PubMed:36302773). E3 ubiquitin-protein ligase activity is dependent on the E2 ubiquitin-conjugating enzyme UBE2D3 (PubMed:28685749). Also acts as an adapter that recruits the 4EHP-GYF2 complex to mRNAs (PubMed:22751931, PubMed:32726578). Independently of its role in RQC, may also act as a negative regulator of interferon-stimulated gene (ISG) expression (PubMed:29719242). {ECO:0000269\|PubMed:22751931, ECO:0000269\|PubMed:28065601, ECO:0000269\|PubMed:28132843, ECO:0000269\|PubMed:28685749, ECO:0000269\|PubMed:29719242, ECO:0000269\|PubMed:30293783, ECO:0000269\|PubMed:32099016, ECO:0000269\|PubMed:32579943, ECO:0000269\|PubMed:32726578, ECO:0000269\|PubMed:33581075, ECO:0000269\|PubMed:36302773}.; FUNCTION: (Microbial infection) Required for poxvirus protein synthesis by mediating ubiquitination of RPS10/eS10 and RPS20/uS10 (PubMed:29719242). Poxvirus encoding mRNAs contain unusual 5' poly(A) leaders and ZNF598 is required for their translational efficiency, possibly via its ability to suppress readthrough or sliding on shorter poly(A) tracts (PubMed:29719242). {ECO:0000269\|PubMed:29719242}.
O96019	ACTL6A	T72	Sugiyama	Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250\|UniProtKB:Q9Z2N8, ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:29374058, ECO:0000303\|PubMed:15196461, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
P62191	PSMC1	T230	Sugiyama	26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269\|PubMed:1317798}.
P46779	RPL28	T75	Sugiyama	Large ribosomal subunit protein eL28 (60S ribosomal protein L28)	Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547, ECO:0000305\|PubMed:12962325}.
P54136	RARS1	T215	Sugiyama	Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)	Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). {ECO:0000269\|PubMed:17443684, ECO:0000269\|PubMed:25288775}.
Q9ULX6	AKAP8L	T267	Sugiyama	A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95)	Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). {ECO:0000269\|PubMed:10748171, ECO:0000269\|PubMed:11034899, ECO:0000269\|PubMed:11402034, ECO:0000269\|PubMed:11884601, ECO:0000269\|PubMed:12538639, ECO:0000269\|PubMed:16980585, ECO:0000305\|PubMed:10761695}.; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. {ECO:0000269\|PubMed:11884601}.; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. {ECO:0000269\|PubMed:11402034}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. {ECO:0000269\|PubMed:25034436}.
P13987	CD59	T76	Sugiyama	CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)	Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260). {ECO:0000269\|PubMed:11882685, ECO:0000269\|PubMed:1698710, ECO:0000269\|PubMed:2475111, ECO:0000269\|PubMed:2475570, ECO:0000269\|PubMed:2606909, ECO:0000269\|PubMed:36797260, ECO:0000269\|PubMed:9053451}.; FUNCTION: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes. {ECO:0000269\|PubMed:8670172}.
Q92598	HSPH1	T63	Sugiyama	Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1)	Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250\|UniProtKB:Q60446, ECO:0000250\|UniProtKB:Q61699, ECO:0000269\|PubMed:24318877}.
O00203	AP3B1	T424	Sugiyama	AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)	Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000305\|PubMed:9151686}.
P00338	LDHA	T275	Sugiyama	L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)	Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269\|PubMed:11276087}.
P12268	IMPDH2	T252	Sugiyama	Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II)	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000269\|PubMed:14766016, ECO:0000269\|PubMed:7763314, ECO:0000269\|PubMed:7903306}.
P35268	RPL22	T62	Sugiyama	Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15)	Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:32669547}.
P40925	MDH1	T135	Sugiyama	Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)	Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). {ECO:0000269\|PubMed:2449162, ECO:0000269\|PubMed:3052244, ECO:0000269\|PubMed:31538237}.
P40939	HADHA	T393	Sugiyama	Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]	Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:1550553, PubMed:29915090, PubMed:30850536, PubMed:8135828, PubMed:31604922). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536, PubMed:31604922). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed:29915090, PubMed:30850536, PubMed:8135828). Independently of subunit beta, HADHA also exhibits a cardiolipin acyltransferase activity that participates in cardiolipin remodeling; cardiolipin is a major mitochondrial membrane phospholipid (PubMed:23152787, PubMed:31604922). HADHA may act downstream of Tafazzin/TAZ, that remodels monolysocardiolipin (MLCL) to a cardiolipin intermediate, and then HADHA may continue to remodel this species into mature tetralinoleoyl-cardiolipin (PubMed:31604922). Has also been proposed to act directly on MLCL; capable of acylating MLCL using different acyl-CoA substrates, with highest activity for oleoyl-CoA (PubMed:23152787). {ECO:0000269\|PubMed:1550553, ECO:0000269\|PubMed:23152787, ECO:0000269\|PubMed:29915090, ECO:0000269\|PubMed:30850536, ECO:0000269\|PubMed:31604922, ECO:0000269\|PubMed:8135828, ECO:0000303\|PubMed:29915090, ECO:0000303\|PubMed:30850536}.
Q13347	EIF3I	T218	Sugiyama	Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255\|HAMAP-Rule:MF_03008, ECO:0000269\|PubMed:17581632, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.
Q86UE4	MTDH	T477	Sugiyama	Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)	Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269\|PubMed:15927426, ECO:0000269\|PubMed:16452207, ECO:0000269\|PubMed:18316612, ECO:0000269\|PubMed:19111877}.
Q9BZI7	UPF3B	T153	Sugiyama	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X)	Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core. {ECO:0000269\|PubMed:11163187, ECO:0000269\|PubMed:12718880, ECO:0000269\|PubMed:16209946, ECO:0000269\|PubMed:16601204, ECO:0000269\|PubMed:18066079}.
Q9Y230	RUVBL2	T194	Sugiyama	RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)	Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:10428817, PubMed:17157868, PubMed:33205750). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (PubMed:14966270). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379). May also inhibit the transcriptional activity of ATF2 (PubMed:11713276). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026). {ECO:0000269\|PubMed:10428817, ECO:0000269\|PubMed:10882073, ECO:0000269\|PubMed:11713276, ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:16014379, ECO:0000269\|PubMed:16230350, ECO:0000269\|PubMed:17157868, ECO:0000269\|PubMed:21303910, ECO:0000269\|PubMed:24463511, ECO:0000269\|PubMed:25652260, ECO:0000269\|PubMed:28561026, ECO:0000269\|PubMed:33205750}.
P16403	H1-2	T167	EPSD\|PSP	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Q99497	PARK7	T140	Sugiyama	Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124)	Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:14749723, PubMed:15502874, PubMed:17015834, PubMed:18711745, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:26995087, PubMed:28013050). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:28993701, PubMed:31653696). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:16632486, PubMed:19229105). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250\|UniProtKB:Q99LX0, ECO:0000269\|PubMed:11477070, ECO:0000269\|PubMed:12612053, ECO:0000269\|PubMed:12855764, ECO:0000269\|PubMed:12939276, ECO:0000269\|PubMed:14749723, ECO:0000269\|PubMed:15181200, ECO:0000269\|PubMed:15502874, ECO:0000269\|PubMed:15976810, ECO:0000269\|PubMed:16390825, ECO:0000269\|PubMed:17015834, ECO:0000269\|PubMed:18626009, ECO:0000269\|PubMed:18711745, ECO:0000269\|PubMed:19229105, ECO:0000269\|PubMed:20186336, ECO:0000269\|PubMed:20304780, ECO:0000269\|PubMed:21097510, ECO:0000269\|PubMed:22523093, ECO:0000269\|PubMed:23792957, ECO:0000269\|PubMed:23847046, ECO:0000269\|PubMed:25416785, ECO:0000269\|PubMed:26995087, ECO:0000269\|PubMed:28013050, ECO:0000269\|PubMed:28596309, ECO:0000269\|PubMed:28993701, ECO:0000269\|PubMed:30150385, ECO:0000269\|PubMed:30894531, ECO:0000269\|PubMed:9070310}.
P06899	H2BC11	Y38	Sugiyama	Histone H2B type 1-J (Histone H2B.1) (Histone H2B.r) (H2B/r)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
P23527	H2BC17	Y38	Sugiyama	Histone H2B type 1-O (H2B-clustered histone 17) (Histone H2B.2) (Histone H2B.n) (H2B/n)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P33778	H2BC3	Y38	Sugiyama	Histone H2B type 1-B (H2B-clustered histone 3) (Histone H2B.1) (Histone H2B.f) (H2B/f)	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P61978	HNRNPK	T70	Sugiyama	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)	One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). {ECO:0000250, ECO:0000269\|PubMed:16360036, ECO:0000269\|PubMed:20673990, ECO:0000269\|PubMed:22825850, ECO:0000269\|PubMed:33174841}.
Q9ULT8	HECTD1	T1873	Sugiyama	E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250\|UniProtKB:Q69ZR2, ECO:0000269\|PubMed:33711283}.
P05771	PRKCB	T226	Sugiyama	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250\|UniProtKB:P68404, ECO:0000269\|PubMed:11598012, ECO:0000269\|PubMed:19176525, ECO:0000269\|PubMed:20228790, ECO:0000269\|PubMed:25313067, ECO:0000269\|PubMed:25982116, ECO:0000269\|PubMed:36040231}.
P02545	LMNA	T480	ELM	Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]	[Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269\|PubMed:10080180, ECO:0000269\|PubMed:10580070, ECO:0000269\|PubMed:10587585, ECO:0000269\|PubMed:10814726, ECO:0000269\|PubMed:11799477, ECO:0000269\|PubMed:12075506, ECO:0000269\|PubMed:12927431, ECO:0000269\|PubMed:15317753, ECO:0000269\|PubMed:18551513, ECO:0000269\|PubMed:18611980, ECO:0000269\|PubMed:2188730, ECO:0000269\|PubMed:22431096, ECO:0000269\|PubMed:2344612, ECO:0000269\|PubMed:23666920, ECO:0000269\|PubMed:23990565, ECO:0000269\|PubMed:24741066, ECO:0000269\|PubMed:25127216, ECO:0000269\|PubMed:31434876, ECO:0000269\|PubMed:31548606, ECO:0000269\|PubMed:37788673, ECO:0000269\|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269\|PubMed:20458013}.
Q9Y5S8	NOX1	T430	SIGNOR	NADPH oxidase 1 (NOX-1) (EC 1.6.3.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1)	NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269\|PubMed:14617635, ECO:0000269\|PubMed:16329988, ECO:0000269\|PubMed:16636067, ECO:0000269\|PubMed:19755710}.; FUNCTION: [Isoform NOH-1L]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269\|PubMed:10485709}.
P37108	SRP14	T29	Sugiyama	Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein)	Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:11089964). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (PubMed:11089964). The complex of SRP9 and SRP14 is required for SRP RNA binding (PubMed:11089964). {ECO:0000269\|PubMed:11089964}.
Q13127	REST	T419	Sugiyama	RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor)	Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). {ECO:0000250\|UniProtKB:O54963, ECO:0000250\|UniProtKB:Q8VIG1, ECO:0000269\|PubMed:10449787, ECO:0000269\|PubMed:10734093, ECO:0000269\|PubMed:11741002, ECO:0000269\|PubMed:11779185, ECO:0000269\|PubMed:12399542, ECO:0000269\|PubMed:19061646, ECO:0000269\|PubMed:21258371, ECO:0000269\|PubMed:24670762, ECO:0000269\|PubMed:26053433, ECO:0000269\|PubMed:26551668, ECO:0000269\|PubMed:27531581, ECO:0000269\|PubMed:7697725, ECO:0000269\|PubMed:7871435, ECO:0000269\|PubMed:8568247}.; FUNCTION: [Isoform 3]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250\|UniProtKB:Q8VIG1, ECO:0000269\|PubMed:11741002, ECO:0000269\|PubMed:11779185}.
P30260	CDC27	T329	EPSD\|PSP	Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269\|PubMed:18485873, ECO:0000269\|PubMed:29033132}.
P11142	HSPA8	T425	Sugiyama	Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250\|UniProtKB:P19120, ECO:0000269\|PubMed:10722728, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:11559757, ECO:0000269\|PubMed:12526792, ECO:0000269\|PubMed:15894275, ECO:0000269\|PubMed:21148293, ECO:0000269\|PubMed:21150129, ECO:0000269\|PubMed:23018488, ECO:0000269\|PubMed:23990462, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24732912, ECO:0000269\|PubMed:27474739, ECO:0000269\|PubMed:27916661, ECO:0000269\|PubMed:2799391, ECO:0000269\|PubMed:36586411, ECO:0000303\|PubMed:24121476, ECO:0000303\|PubMed:26865365}.
P34931	HSPA1L	T427	Sugiyama	Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269\|PubMed:24270810, ECO:0000303\|PubMed:26865365}.
Q9BXS5	AP1M1	T306	Sugiyama	AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
P24723	PRKCH	T183	Sugiyama	Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta)	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269\|PubMed:10806212, ECO:0000269\|PubMed:11112424, ECO:0000269\|PubMed:11772428, ECO:0000269\|PubMed:15489897, ECO:0000269\|PubMed:17146445, ECO:0000269\|PubMed:18780722, ECO:0000269\|PubMed:19114660, ECO:0000269\|PubMed:20558593, ECO:0000269\|PubMed:21820409, ECO:0000269\|PubMed:22304920}.
P24723	PRKCH	T601	Sugiyama	Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta)	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269\|PubMed:10806212, ECO:0000269\|PubMed:11112424, ECO:0000269\|PubMed:11772428, ECO:0000269\|PubMed:15489897, ECO:0000269\|PubMed:17146445, ECO:0000269\|PubMed:18780722, ECO:0000269\|PubMed:19114660, ECO:0000269\|PubMed:20558593, ECO:0000269\|PubMed:21820409, ECO:0000269\|PubMed:22304920}.
Q02156	PRKCE	T181	Sugiyama	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000269\|PubMed:11884385, ECO:0000269\|PubMed:1374067, ECO:0000269\|PubMed:15355962, ECO:0000269\|PubMed:16757566, ECO:0000269\|PubMed:17603037, ECO:0000269\|PubMed:17875639, ECO:0000269\|PubMed:17875724, ECO:0000269\|PubMed:19542546, ECO:0000269\|PubMed:21806543, ECO:0000269\|PubMed:36040231}.
Q8WVM8	SCFD1	T320	Sugiyama	Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2)	Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). {ECO:0000250}.
P30291	WEE1	T615	Sugiyama	Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)	Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15' (PubMed:15070733, PubMed:7743995, PubMed:8348613, PubMed:8428596). Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase (PubMed:7743995, PubMed:8348613, PubMed:8428596). Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (PubMed:7743995, PubMed:8348613, PubMed:8428596). Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated (PubMed:7743995). A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (PubMed:7743995). {ECO:0000269\|PubMed:15070733, ECO:0000269\|PubMed:7743995, ECO:0000269\|PubMed:8348613, ECO:0000269\|PubMed:8428596}.
P35916	FLT4	T1263	Sugiyama	Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269\|PubMed:11532940, ECO:0000269\|PubMed:15102829, ECO:0000269\|PubMed:15474514, ECO:0000269\|PubMed:16076871, ECO:0000269\|PubMed:16452200, ECO:0000269\|PubMed:17210781, ECO:0000269\|PubMed:19610651, ECO:0000269\|PubMed:19779139, ECO:0000269\|PubMed:20224550, ECO:0000269\|PubMed:20431062, ECO:0000269\|PubMed:20445537, ECO:0000269\|PubMed:21273538, ECO:0000269\|PubMed:7675451, ECO:0000269\|PubMed:8700872, ECO:0000269\|PubMed:9435229}.
P37023	ACVRL1	T450	Sugiyama	Activin receptor type-1-like (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (Serine/threonine-protein kinase receptor R3) (SKR3) (TGF-B superfamily receptor type I) (TSR-I)	Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269\|PubMed:22718755, ECO:0000269\|PubMed:22799562, ECO:0000269\|PubMed:26176610}.
Q68BL8	OLFML2B	T505	Sugiyama	Olfactomedin-like protein 2B (Photomedin-2)	None
Q9H3P7	ACBD3	T396	Sugiyama	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]	Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356). {ECO:0000250\|UniProtKB:Q8BMP6, ECO:0000269\|PubMed:11590181, ECO:0000269\|PubMed:27009356}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites. {ECO:0000269\|PubMed:22124328, ECO:0000269\|PubMed:22258260, ECO:0000269\|PubMed:27989622}.
O60563	CCNT1	T216	Sugiyama	Cyclin-T1 (CycT1) (Cyclin-T)	Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269\|PubMed:16109376, ECO:0000269\|PubMed:16109377, ECO:0000269\|PubMed:29849146, ECO:0000269\|PubMed:30134174, ECO:0000269\|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269\|PubMed:10329125, ECO:0000269\|PubMed:10329126}.
O60583	CCNT2	T215	Sugiyama	Cyclin-T2 (CycT2)	Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250\|UniProtKB:Q7TQK0, ECO:0000269\|PubMed:11713533, ECO:0000269\|PubMed:15563843, ECO:0000269\|PubMed:16331689, ECO:0000269\|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269\|PubMed:21509660}.
P30622	CLIP1	T27	Sugiyama	CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)	Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269\|PubMed:12433698, ECO:0000269\|PubMed:17563362, ECO:0000269\|PubMed:17889670}.
P35579	MYH9	T1764	Sugiyama	Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250\|UniProtKB:Q8VDD5, ECO:0000269\|PubMed:16707441, ECO:0000269\|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269\|PubMed:20944748, ECO:0000269\|PubMed:39048823}.
P46782	RPS5	T73	Sugiyama	Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)]	Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:34516797}.
O15347	HMGB3	T22	Sugiyama	High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4)	Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). {ECO:0000250\|UniProtKB:O54879, ECO:0000250\|UniProtKB:P09429, ECO:0000250\|UniProtKB:P40618}.
Q9UNF1	MAGED2	T117	Sugiyama	Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen)	Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269\|PubMed:27120771}.
P09960	LTA4H	T490	Sugiyama	Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4)	Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269\|PubMed:11917124, ECO:0000269\|PubMed:12207002, ECO:0000269\|PubMed:15078870, ECO:0000269\|PubMed:18804029, ECO:0000269\|PubMed:1897988, ECO:0000269\|PubMed:1975494, ECO:0000269\|PubMed:20813919, ECO:0000269\|PubMed:21206090, ECO:0000269\|PubMed:2244921, ECO:0000269\|PubMed:24591641}.
P33981	TTK	T210	SIGNOR\|PSP	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)	Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269\|PubMed:18243099, ECO:0000269\|PubMed:28441529, ECO:0000269\|PubMed:29162720, ECO:0000269\|PubMed:30785839}.
Q96E11	MRRF	T230	Sugiyama	Ribosome-recycling factor, mitochondrial (RRF) (mtRRF) (Ribosome-releasing factor, mitochondrial)	Responsible for the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis (PubMed:19716793, PubMed:33878294). Acts in collaboration with GFM2 (PubMed:33878294). Promotes mitochondrial ribosome recycling by dissolution of intersubunit contacts (PubMed:33878294). {ECO:0000269\|PubMed:19716793, ECO:0000269\|PubMed:33878294}.
P08758	ANXA5	T196	Sugiyama	Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)	This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
P30041	PRDX6	T192	Sugiyama	Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860). {ECO:0000269\|PubMed:10893423, ECO:0000269\|PubMed:26830860, ECO:0000269\|PubMed:9497358}.
P38646	HSPA9	T185	Sugiyama	Stress-70 protein, mitochondrial (EC 3.6.4.10) (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)	Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones (PubMed:18632665, PubMed:25615450, PubMed:28848044, PubMed:30933555, PubMed:31177526). In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (PubMed:24625977, PubMed:26634371). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (PubMed:16091382). {ECO:0000250\|UniProtKB:P0CS90, ECO:0000250\|UniProtKB:P38647, ECO:0000269\|PubMed:16091382, ECO:0000269\|PubMed:18632665, ECO:0000269\|PubMed:21123823, ECO:0000269\|PubMed:24625977, ECO:0000269\|PubMed:25615450, ECO:0000269\|PubMed:26634371, ECO:0000269\|PubMed:26702583, ECO:0000269\|PubMed:28848044, ECO:0000269\|PubMed:30933555, ECO:0000269\|PubMed:31177526}.
P48643	CCT5	T69	Sugiyama	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000269\|PubMed:35449234, ECO:0000269\|PubMed:36493755, ECO:0000269\|PubMed:37193829}.
P50990	CCT8	T374	Sugiyama	T-complex protein 1 subunit theta (TCP-1-theta) (EC 3.6.1.-) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000269\|PubMed:35449234, ECO:0000269\|PubMed:36493755, ECO:0000269\|PubMed:37193829}.
Q00534	CDK6	T267	Sugiyama	Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)	Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and negatively regulates cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269\|PubMed:12833137, ECO:0000269\|PubMed:14985467, ECO:0000269\|PubMed:15254224, ECO:0000269\|PubMed:15809340, ECO:0000269\|PubMed:17420273, ECO:0000269\|PubMed:17431401, ECO:0000269\|PubMed:20333249, ECO:0000269\|PubMed:20668294, ECO:0000269\|PubMed:23918663, ECO:0000269\|PubMed:8114739}.
P53779	MAPK10	T131	SIGNOR	Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)	Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269\|PubMed:11718727, ECO:0000269\|PubMed:22327296, ECO:0000269\|PubMed:22441692}.
Q13287	NMI	T229	Sugiyama	N-myc-interactor (Nmi) (N-myc and STAT interactor)	Acts as a signaling pathway regulator involved in innate immune system response (PubMed:26342464, PubMed:29038465, PubMed:29350881, PubMed:9989503). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (PubMed:29377960, PubMed:9989503). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (PubMed:9989503). In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (PubMed:10779520, PubMed:10950963). In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21 (PubMed:26342464). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (By similarity). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (PubMed:29038465). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (PubMed:29038465). {ECO:0000250\|UniProtKB:O35309, ECO:0000269\|PubMed:10779520, ECO:0000269\|PubMed:10950963, ECO:0000269\|PubMed:26342464, ECO:0000269\|PubMed:29038465, ECO:0000269\|PubMed:29350881, ECO:0000269\|PubMed:9989503}.
P61964	WDR5	T237	Sugiyama	WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)	Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250\|UniProtKB:P61965, ECO:0000269\|PubMed:16600877, ECO:0000269\|PubMed:16829960, ECO:0000269\|PubMed:18840606, ECO:0000269\|PubMed:19103755, ECO:0000269\|PubMed:19131338, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20018852, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:22266653}.
Q9H173	SIL1	T127	Sugiyama	Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP)	Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269\|PubMed:12356756}.
Q9UKX7	NUP50	T54	Sugiyama	Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)	Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250\|UniProtKB:Q9JIH2, ECO:0000269\|PubMed:20016008}.
O75369	FLNB	T490	Sugiyama	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O95861	BPNT1	T287	Sugiyama	3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (HsPIP) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57)	Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and inositol 1,4-bisphosphate (Ins(1,4)P2) to inositol 4-phosphate (PubMed:10675562). Is also able to hydrolyze adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) (By similarity). Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism. Is not active on 3'-AMP, inositol-1-phosphate and inositol-1,4,5-triphosphate (PubMed:10675562). {ECO:0000250\|UniProtKB:Q9Z1N4, ECO:0000269\|PubMed:10675562}.
P10809	HSPD1	T320	Sugiyama	60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)	Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269\|PubMed:11422376, ECO:0000269\|PubMed:1346131, ECO:0000305\|PubMed:25918392}.
P19338	NCL	T304	Sugiyama	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P19338	NCL	T305	Sugiyama	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
Q13188	STK3	T20	Sugiyama	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714, PubMed:29063833, PubMed:30622739). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:15688006, PubMed:16930133, PubMed:23972470, PubMed:28087714). STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250 (PubMed:21076410, PubMed:21723128). In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (PubMed:21104395). Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259' (PubMed:20212043). Phosphorylates MOBKL1A and RASSF2 (PubMed:19525978). Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38 (PubMed:18328708, PubMed:18362890). {ECO:0000250\|UniProtKB:Q9JI10, ECO:0000269\|PubMed:11278283, ECO:0000269\|PubMed:15688006, ECO:0000269\|PubMed:16930133, ECO:0000269\|PubMed:18328708, ECO:0000269\|PubMed:18362890, ECO:0000269\|PubMed:19525978, ECO:0000269\|PubMed:20212043, ECO:0000269\|PubMed:21076410, ECO:0000269\|PubMed:21104395, ECO:0000269\|PubMed:21723128, ECO:0000269\|PubMed:23972470, ECO:0000269\|PubMed:28087714, ECO:0000269\|PubMed:29063833, ECO:0000269\|PubMed:30622739, ECO:0000269\|PubMed:8566796, ECO:0000269\|PubMed:8816758}.
P39687	ANP32A	T126	Sugiyama	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI)	Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269\|PubMed:10400610, ECO:0000269\|PubMed:11360199, ECO:0000269\|PubMed:11830591, ECO:0000269\|PubMed:15642345, ECO:0000269\|PubMed:16341127, ECO:0000269\|PubMed:17557114, ECO:0000269\|PubMed:18180367, ECO:0000269\|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269\|PubMed:21159877, ECO:0000269\|PubMed:30666459, ECO:0000269\|PubMed:32694517, ECO:0000269\|PubMed:33045004, ECO:0000269\|PubMed:33208942}.
O14974	PPP1R12A	T500	SIGNOR	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)	Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269\|PubMed:18477460, ECO:0000269\|PubMed:19245366, ECO:0000269\|PubMed:20354225}.
Q92804	TAF15	T287	Sugiyama	TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)	RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269\|PubMed:19124016, ECO:0000269\|PubMed:21256132}.
Q14012	CAMK1	T310	Sugiyama	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269\|PubMed:11114197, ECO:0000269\|PubMed:12193581, ECO:0000269\|PubMed:14507913, ECO:0000269\|PubMed:14754892, ECO:0000269\|PubMed:17056143, ECO:0000269\|PubMed:17442826, ECO:0000269\|PubMed:18184567, ECO:0000269\|PubMed:20181577}.
Q8IU85	CAMK1D	T313	Sugiyama	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK)	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269\|PubMed:11050006, ECO:0000269\|PubMed:15840691, ECO:0000269\|PubMed:16324104, ECO:0000269\|PubMed:17056143}.
P49137	MAPKAPK2	T317	SIGNOR\|iPTMNet	MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)	Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269\|PubMed:10383393, ECO:0000269\|PubMed:11844797, ECO:0000269\|PubMed:12456657, ECO:0000269\|PubMed:12565831, ECO:0000269\|PubMed:14499342, ECO:0000269\|PubMed:14517288, ECO:0000269\|PubMed:15014438, ECO:0000269\|PubMed:15629715, ECO:0000269\|PubMed:16278218, ECO:0000269\|PubMed:16456544, ECO:0000269\|PubMed:17481585, ECO:0000269\|PubMed:18021073, ECO:0000269\|PubMed:20932473, ECO:0000269\|PubMed:26616734, ECO:0000269\|PubMed:8093612, ECO:0000269\|PubMed:8280084, ECO:0000269\|PubMed:8774846}.
O94776	MTA2	T621	Sugiyama	Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)	May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:28977666}.
P29083	GTF2E1	T285	Sugiyama	General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)	Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Q5S007	LRRK2	T1470	EPSD\|PSP	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269\|PubMed:17114044, ECO:0000269\|PubMed:18230735, ECO:0000269\|PubMed:20949042, ECO:0000269\|PubMed:21850687, ECO:0000269\|PubMed:22012985, ECO:0000269\|PubMed:23395371, ECO:0000269\|PubMed:24687852, ECO:0000269\|PubMed:25201882, ECO:0000269\|PubMed:26014385, ECO:0000269\|PubMed:26824392, ECO:0000269\|PubMed:27830463, ECO:0000269\|PubMed:28720718, ECO:0000269\|PubMed:29125462, ECO:0000269\|PubMed:29127255, ECO:0000269\|PubMed:29212815, ECO:0000269\|PubMed:30209220, ECO:0000269\|PubMed:30398148, ECO:0000269\|PubMed:30635421, ECO:0000269\|PubMed:38127736, ECO:0000269\|PubMed:38227290}.
P80303	NUCB2	T236	Sugiyama	Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]	Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250\|UniProtKB:P81117, ECO:0000250\|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250\|UniProtKB:Q9JI85, ECO:0000269\|PubMed:39562740}.
Q92688	ANP32B	T126	Sugiyama	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29)	Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250\|UniProtKB:Q9EST5, ECO:0000269\|PubMed:17178712, ECO:0000269\|PubMed:18039846, ECO:0000269\|PubMed:20015864, ECO:0000269\|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:31217244, PubMed:33045004). Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269\|PubMed:21159877, ECO:0000269\|PubMed:31217244, ECO:0000269\|PubMed:33045004}.
Q6P0Q8	MAST2	T1189	Sugiyama	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}.
O60664	PLIN3	T328	Sugiyama	Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17)	Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269\|PubMed:34077757, ECO:0000269\|PubMed:9590177}.
Q86UE4	MTDH	T326	Sugiyama	Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein)	Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269\|PubMed:15927426, ECO:0000269\|PubMed:16452207, ECO:0000269\|PubMed:18316612, ECO:0000269\|PubMed:19111877}.
Q9NQC3	RTN4	T432	Sugiyama	Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)	Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269\|PubMed:24262037, ECO:0000269\|PubMed:25612671, ECO:0000269\|PubMed:26906412, ECO:0000269\|PubMed:27619977, ECO:0000269\|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:10667797, ECO:0000269\|PubMed:11201742, ECO:0000269\|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:11126360, ECO:0000269\|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250\|UniProtKB:Q99P72, ECO:0000269\|PubMed:16965550}.
Q9NUU7	DDX19A	T73	Sugiyama	ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A)	ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins. {ECO:0000250\|UniProtKB:Q9UMR2}.
Q9UMR2	DDX19B	T74	Sugiyama	ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B)	ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269\|PubMed:10428971}.
Q8IY84	NIM1K	T208	Sugiyama	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase)	None
P04075	ALDOA	T253	Sugiyama	Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)	Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269\|PubMed:14766013}.
Q8N8S7	ENAH	T76	Sugiyama	Protein enabled homolog	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11696321, ECO:0000269\|PubMed:18158903}.
Q8N568	DCLK2	T220	Sugiyama	Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)	Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.
Q8N568	DCLK2	T229	Sugiyama	Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)	Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.
Q9UQN3	CHMP2B	T124	Sugiyama	Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2)	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Q8NG66	NEK11	T19	Sugiyama	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11)	Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269\|PubMed:12154088, ECO:0000269\|PubMed:19734889, ECO:0000269\|PubMed:20090422}.
Q92630	DYRK2	T561	Sugiyama	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)	Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269\|PubMed:11311121, ECO:0000269\|PubMed:12588975, ECO:0000269\|PubMed:14593110, ECO:0000269\|PubMed:15910284, ECO:0000269\|PubMed:16511445, ECO:0000269\|PubMed:16611631, ECO:0000269\|PubMed:17349958, ECO:0000269\|PubMed:18455992, ECO:0000269\|PubMed:18599021, ECO:0000269\|PubMed:19287380, ECO:0000269\|PubMed:22307329, ECO:0000269\|PubMed:22878263, ECO:0000269\|PubMed:23362280, ECO:0000269\|PubMed:9748265}.
Q96J92	WNK4	T314	Sugiyama	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4)	Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16832045). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16832045, PubMed:22989884). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (PubMed:20525693). {ECO:0000250\|UniProtKB:Q80UE6, ECO:0000269\|PubMed:16832045, ECO:0000269\|PubMed:20525693, ECO:0000269\|PubMed:22989884}.
Q99683	MAP3K5	T779	Sugiyama	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269\|PubMed:10411906, ECO:0000269\|PubMed:10688666, ECO:0000269\|PubMed:10849426, ECO:0000269\|PubMed:11029458, ECO:0000269\|PubMed:11154276, ECO:0000269\|PubMed:11689443, ECO:0000269\|PubMed:11920685, ECO:0000269\|PubMed:14688258, ECO:0000269\|PubMed:14749717, ECO:0000269\|PubMed:15023544, ECO:0000269\|PubMed:16129676, ECO:0000269\|PubMed:17220297, ECO:0000269\|PubMed:23102700, ECO:0000269\|PubMed:26095851, ECO:0000269\|PubMed:8940179, ECO:0000269\|PubMed:8974401, ECO:0000269\|PubMed:9564042, ECO:0000269\|PubMed:9774977}.
Q99759	MAP3K3	T462	Sugiyama	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)	Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269\|PubMed:12912994, ECO:0000269\|PubMed:14661019, ECO:0000269\|PubMed:14743216, ECO:0000269\|PubMed:33729480, ECO:0000269\|PubMed:33891857, ECO:0000269\|PubMed:9006902}.
Q9BYP7	WNK3	T52	Sugiyama	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)	Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269\|PubMed:16275911, ECO:0000269\|PubMed:16275913, ECO:0000269\|PubMed:16357011, ECO:0000269\|PubMed:16501604, ECO:0000269\|PubMed:17673510, ECO:0000269\|PubMed:17975670, ECO:0000269\|PubMed:18768590, ECO:0000269\|PubMed:19470686, ECO:0000269\|PubMed:20525693, ECO:0000269\|PubMed:21613606, ECO:0000269\|PubMed:22989884, ECO:0000269\|PubMed:36318922}.
Q9H093	NUAK2	T365	Sugiyama	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK)	Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269\|PubMed:14575707, ECO:0000269\|PubMed:14976552, ECO:0000269\|PubMed:15345718, ECO:0000269\|PubMed:19927127, ECO:0000269\|PubMed:32845958}.
Q9H0K1	SIK2	T696	Sugiyama	Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)	Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250\|UniProtKB:Q8CFH6, ECO:0000269\|PubMed:15454081, ECO:0000269\|PubMed:21084751, ECO:0000269\|PubMed:23322770, ECO:0000269\|PubMed:26983400}.
Q9H2X6	HIPK2	T42	Sugiyama	Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)	Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269\|PubMed:11740489, ECO:0000269\|PubMed:11925430, ECO:0000269\|PubMed:12851404, ECO:0000269\|PubMed:12874272, ECO:0000269\|PubMed:14678985, ECO:0000269\|PubMed:17018294, ECO:0000269\|PubMed:17960875, ECO:0000269\|PubMed:18695000, ECO:0000269\|PubMed:18809579, ECO:0000269\|PubMed:19015637, ECO:0000269\|PubMed:19046997, ECO:0000269\|PubMed:19448668, ECO:0000269\|PubMed:20307497, ECO:0000269\|PubMed:20573984, ECO:0000269\|PubMed:20637728, ECO:0000269\|PubMed:20980392, ECO:0000269\|PubMed:21192925, ECO:0000269\|PubMed:22825850, ECO:0000269\|PubMed:33591310}.
Q9BYP7	WNK3	T287	Sugiyama	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)	Serine/threonine-protein kinase component of the WNK3-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis and regulatory volume increase in response to hyperosmotic stress (PubMed:16275911, PubMed:16275913, PubMed:16501604, PubMed:22989884, PubMed:36318922). WNK3 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK3 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK3-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:22989884). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A4/KCC1, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:16275911, PubMed:16275913). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A4/KCC1, SLC12A5/KCC2 and SLC12A6/KCC3 inhibits its activity, blocking ion efflux (PubMed:16275911, PubMed:16275913, PubMed:16357011, PubMed:19470686, PubMed:21613606). Phosphorylates WNK4, possibly regulating the activity of SLC12A3/NCC (PubMed:17975670). May also phosphorylate NEDD4L (PubMed:20525693). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as KCNJ1 and SLC26A9 (PubMed:16357011, PubMed:17673510). Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). {ECO:0000269\|PubMed:16275911, ECO:0000269\|PubMed:16275913, ECO:0000269\|PubMed:16357011, ECO:0000269\|PubMed:16501604, ECO:0000269\|PubMed:17673510, ECO:0000269\|PubMed:17975670, ECO:0000269\|PubMed:18768590, ECO:0000269\|PubMed:19470686, ECO:0000269\|PubMed:20525693, ECO:0000269\|PubMed:21613606, ECO:0000269\|PubMed:22989884, ECO:0000269\|PubMed:36318922}.
Q9H4A3	WNK1	T361	Sugiyama	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)	Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250\|UniProtKB:P83741, ECO:0000250\|UniProtKB:Q9JIH7, ECO:0000269\|PubMed:10660600, ECO:0000269\|PubMed:15883153, ECO:0000269\|PubMed:16263722, ECO:0000269\|PubMed:17190791, ECO:0000269\|PubMed:19665974, ECO:0000269\|PubMed:19739668, ECO:0000269\|PubMed:21220314, ECO:0000269\|PubMed:21321328, ECO:0000269\|PubMed:22989884, ECO:0000269\|PubMed:25362046, ECO:0000269\|PubMed:25477473, ECO:0000269\|PubMed:27911840, ECO:0000269\|PubMed:29196535, ECO:0000269\|PubMed:31656913, ECO:0000269\|PubMed:33964204, ECO:0000269\|PubMed:34289367, ECO:0000269\|PubMed:36318922, ECO:0000269\|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250\|UniProtKB:Q9JIH7, ECO:0000269\|PubMed:14645531}.
Q9H4A3	WNK1	T48	Sugiyama	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)	Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250\|UniProtKB:P83741, ECO:0000250\|UniProtKB:Q9JIH7, ECO:0000269\|PubMed:10660600, ECO:0000269\|PubMed:15883153, ECO:0000269\|PubMed:16263722, ECO:0000269\|PubMed:17190791, ECO:0000269\|PubMed:19665974, ECO:0000269\|PubMed:19739668, ECO:0000269\|PubMed:21220314, ECO:0000269\|PubMed:21321328, ECO:0000269\|PubMed:22989884, ECO:0000269\|PubMed:25362046, ECO:0000269\|PubMed:25477473, ECO:0000269\|PubMed:27911840, ECO:0000269\|PubMed:29196535, ECO:0000269\|PubMed:31656913, ECO:0000269\|PubMed:33964204, ECO:0000269\|PubMed:34289367, ECO:0000269\|PubMed:36318922, ECO:0000269\|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250\|UniProtKB:Q9JIH7, ECO:0000269\|PubMed:14645531}.
Q9H4A3	WNK1	T73	Sugiyama	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)	Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:15883153, PubMed:17190791, PubMed:31656913, PubMed:34289367, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:15883153, PubMed:16263722, PubMed:17190791, PubMed:19739668, PubMed:21321328, PubMed:22989884, PubMed:25477473, PubMed:34289367, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:16263722, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:19665974, PubMed:21321328). Also acts as a regulator of angiogenesis in endothelial cells via activation of OXSR1/OSR1 and STK39/SPAK: activation of OXSR1/OSR1 regulates chemotaxis and invasion, while STK39/SPAK regulates endothelial cell proliferation (PubMed:25362046). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:29196535). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (By similarity). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (PubMed:29196535). Acts as a negative regulator of autophagy (PubMed:27911840). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (PubMed:21220314). May also play a role in actin cytoskeletal reorganization (PubMed:10660600). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (By similarity). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner: probably acts as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (PubMed:36373794). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (PubMed:33964204). {ECO:0000250\|UniProtKB:P83741, ECO:0000250\|UniProtKB:Q9JIH7, ECO:0000269\|PubMed:10660600, ECO:0000269\|PubMed:15883153, ECO:0000269\|PubMed:16263722, ECO:0000269\|PubMed:17190791, ECO:0000269\|PubMed:19665974, ECO:0000269\|PubMed:19739668, ECO:0000269\|PubMed:21220314, ECO:0000269\|PubMed:21321328, ECO:0000269\|PubMed:22989884, ECO:0000269\|PubMed:25362046, ECO:0000269\|PubMed:25477473, ECO:0000269\|PubMed:27911840, ECO:0000269\|PubMed:29196535, ECO:0000269\|PubMed:31656913, ECO:0000269\|PubMed:33964204, ECO:0000269\|PubMed:34289367, ECO:0000269\|PubMed:36318922, ECO:0000269\|PubMed:36373794}.; FUNCTION: [Isoform 3]: Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:14645531). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (By similarity). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (By similarity). In kidney, may play an important role regulating sodium and potassium balance (By similarity). {ECO:0000250\|UniProtKB:Q9JIH7, ECO:0000269\|PubMed:14645531}.
Q9Y3S1	WNK2	T335	Sugiyama	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)	Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250\|UniProtKB:Q9H4A3, ECO:0000269\|PubMed:17667937, ECO:0000269\|PubMed:18593598, ECO:0000269\|PubMed:21733846}.
Q9H4B4	PLK3	T80	Sugiyama	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)	Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269\|PubMed:10557092, ECO:0000269\|PubMed:11156373, ECO:0000269\|PubMed:11447225, ECO:0000269\|PubMed:11551930, ECO:0000269\|PubMed:11971976, ECO:0000269\|PubMed:12242661, ECO:0000269\|PubMed:14968113, ECO:0000269\|PubMed:14980500, ECO:0000269\|PubMed:15021912, ECO:0000269\|PubMed:16478733, ECO:0000269\|PubMed:16481012, ECO:0000269\|PubMed:17264206, ECO:0000269\|PubMed:17804415, ECO:0000269\|PubMed:18062778, ECO:0000269\|PubMed:18650425, ECO:0000269\|PubMed:19103756, ECO:0000269\|PubMed:19490146, ECO:0000269\|PubMed:20889502, ECO:0000269\|PubMed:20940307, ECO:0000269\|PubMed:20951827, ECO:0000269\|PubMed:21098032, ECO:0000269\|PubMed:21264284, ECO:0000269\|PubMed:21376736, ECO:0000269\|PubMed:21840391, ECO:0000269\|PubMed:9353331}.
P02786	TFRC	T138	Sugiyama	Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). {ECO:0000250\|UniProtKB:Q62351, ECO:0000269\|PubMed:26214738, ECO:0000269\|PubMed:26642240, ECO:0000269\|PubMed:3568132}.; FUNCTION: (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269\|PubMed:17287727, ECO:0000269\|PubMed:18268337}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of TFRC to enter cells. {ECO:0000269\|PubMed:36779762, ECO:0000269\|PubMed:36779763}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV, MERS-CoV and SARS-CoV-2 viruses that hijack the endocytosis of TFRC to enter cells. {ECO:0000269\|PubMed:36779762}.
Q9Y295	DRG1	T194	Sugiyama	Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-)	Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:23711155, PubMed:29915238, PubMed:37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). {ECO:0000269\|PubMed:19819225, ECO:0000269\|PubMed:23711155, ECO:0000269\|PubMed:28855639, ECO:0000269\|PubMed:29915238, ECO:0000269\|PubMed:37179472}.
P50416	CPT1A	T649	Sugiyama	Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-)	Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). {ECO:0000250\|UniProtKB:P32198, ECO:0000269\|PubMed:11350182, ECO:0000269\|PubMed:14517221, ECO:0000269\|PubMed:16651524, ECO:0000269\|PubMed:29425493, ECO:0000269\|PubMed:38016475, ECO:0000269\|PubMed:9691089}.
P62753	RPS6	T125	Sugiyama	Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33)	Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269\|PubMed:17220279, ECO:0000269\|PubMed:23636399, ECO:0000269\|PubMed:34516797, ECO:0000269\|PubMed:8706699}.
Q9BTD8	RBM42	T362	Sugiyama	RNA-binding protein 42 (RNA-binding motif protein 42)	Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA. {ECO:0000250}.
P04040	CAT	T115	Sugiyama	Catalase (EC 1.11.1.6)	Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269\|PubMed:7882369}.
P62195	PSMC5	T194	Sugiyama	26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269\|PubMed:1317798}.
Q9UBW7	ZMYM2	T157	Sugiyama	Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198)	Involved in the negative regulation of transcription. {ECO:0000269\|PubMed:32891193}.
P11142	HSPA8	T138	Sugiyama	Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250\|UniProtKB:P19120, ECO:0000269\|PubMed:10722728, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:11559757, ECO:0000269\|PubMed:12526792, ECO:0000269\|PubMed:15894275, ECO:0000269\|PubMed:21148293, ECO:0000269\|PubMed:21150129, ECO:0000269\|PubMed:23018488, ECO:0000269\|PubMed:23990462, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24732912, ECO:0000269\|PubMed:27474739, ECO:0000269\|PubMed:27916661, ECO:0000269\|PubMed:2799391, ECO:0000269\|PubMed:36586411, ECO:0000303\|PubMed:24121476, ECO:0000303\|PubMed:26865365}.
Q99439	CNN2	T62	Sugiyama	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)	Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Q9UBT2	UBA2	T174	Sugiyama	SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)	The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269\|PubMed:11451954, ECO:0000269\|PubMed:11481243, ECO:0000269\|PubMed:15660128, ECO:0000269\|PubMed:17643372, ECO:0000269\|PubMed:19443651, ECO:0000269\|PubMed:20164921}.
A6NKT7	RGPD3	T1314	ochoa	RanBP2-like and GRIP domain-containing protein 3	None
E9PCH4	None	T1255	ochoa	Rap guanine nucleotide exchange factor 6	None
O00161	SNAP23	T101	ochoa	Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)	Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
O14686	KMT2D	T4682	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O14979	HNRNPDL	T244	ochoa	Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)	Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269\|PubMed:9538234}.
O15355	PPM1G	T122	ochoa	Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)	None
O43491	EPB41L2	T679	ochoa	Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)	Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269\|PubMed:23870127}.
O43583	DENR	T69	ochoa	Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3)	Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. {ECO:0000269\|PubMed:16982740, ECO:0000269\|PubMed:20713520, ECO:0000269\|PubMed:37875108}.
O43900	PRICKLE3	T412	ochoa	Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6)	Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). {ECO:0000250\|UniProtKB:A8WH69, ECO:0000269\|PubMed:32516135}.
O60293	ZFC3H1	T272	ochoa	Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2)	Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269\|PubMed:27871484}.
O60566	BUB1B	T464	ochoa	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)	Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269\|PubMed:10477750, ECO:0000269\|PubMed:11702782, ECO:0000269\|PubMed:14706340, ECO:0000269\|PubMed:15020684, ECO:0000269\|PubMed:19411850, ECO:0000269\|PubMed:19503101}.
O75469	NR1I2	T57	psp	Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)	Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269\|PubMed:11297522, ECO:0000269\|PubMed:11668216, ECO:0000269\|PubMed:12578355, ECO:0000269\|PubMed:18768384, ECO:0000269\|PubMed:19297428, ECO:0000269\|PubMed:9727070}.
O75691	UTP20	T1741	ochoa	Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6)	Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269\|PubMed:17498821, ECO:0000269\|PubMed:34516797}.
O75821	EIF3G	T190	ochoa	Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255\|HAMAP-Rule:MF_03006, ECO:0000269\|PubMed:17581632, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269\|PubMed:18056426}.
O94953	KDM4B	T1042	ochoa	Lysine-specific demethylase 4B (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B) ([histone H3]-trimethyl-L-lysine(9) demethylase 4B)	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250\|UniProtKB:Q91VY5, ECO:0000269\|PubMed:16603238, ECO:0000269\|PubMed:28262558}.
O95425	SVIL	T552	ochoa	Supervillin (Archvillin) (p205/p250)	[Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269\|PubMed:12711699, ECO:0000269\|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250\|UniProtKB:O46385}.
P00558	PGK1	T363	ochoa	Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)	Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269\|PubMed:18463139, ECO:0000269\|PubMed:2324090, ECO:0000269\|PubMed:26677959, ECO:0000269\|PubMed:26942675, ECO:0000269\|PubMed:30323285, ECO:0000269\|PubMed:36849569, ECO:0000269\|PubMed:7391028}.
P04075	ALDOA	T52	ochoa	Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)	Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269\|PubMed:14766013}.
P04083	ANXA1	T145	ochoa	Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]	Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250\|UniProtKB:P10107, ECO:0000250\|UniProtKB:P19619, ECO:0000269\|PubMed:17008549, ECO:0000269\|PubMed:19625660, ECO:0000269\|PubMed:2532504, ECO:0000269\|PubMed:2936963, ECO:0000269\|PubMed:8425544, ECO:0000269\|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269\|PubMed:15187149, ECO:0000269\|PubMed:22879591, ECO:0000269\|PubMed:25664854}.
P07900	HSP90AA1	T495	ochoa	Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269\|PubMed:11274138, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:12526792, ECO:0000269\|PubMed:15577939, ECO:0000269\|PubMed:15937123, ECO:0000269\|PubMed:20628368, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:25609812, ECO:0000269\|PubMed:27353360, ECO:0000269\|PubMed:29127155, ECO:0000303\|PubMed:25973397, ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305\|PubMed:22066472}.
P08758	ANXA5	T118	ochoa	Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)	This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
P0DJD0	RGPD1	T1298	ochoa	RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)	None
P0DJD1	RGPD2	T1306	ochoa	RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2)	None
P0DMV8	HSPA1A	T502	ochoa	Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Required as a co-chaperone for optimal STUB1/CHIP ubiquitination of NFATC3 (By similarity). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000250\|UniProtKB:P0DMW0, ECO:0000269\|PubMed:22528486, ECO:0000269\|PubMed:23973223, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:27137183, ECO:0000269\|PubMed:27708256, ECO:0000269\|PubMed:28842558, ECO:0000269\|PubMed:9499401, ECO:0000303\|PubMed:24012426, ECO:0000303\|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269\|PubMed:16537599}.
P0DMV9	HSPA1B	T502	ochoa	Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). {ECO:0000269\|PubMed:22528486, ECO:0000269\|PubMed:23973223, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:27137183, ECO:0000269\|PubMed:27708256, ECO:0000303\|PubMed:24012426, ECO:0000303\|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269\|PubMed:16537599}.
P11021	HSPA5	T525	ochoa	Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)	Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250\|UniProtKB:G3I8R9, ECO:0000250\|UniProtKB:P20029, ECO:0000269\|PubMed:11907036, ECO:0000269\|PubMed:1550958, ECO:0000269\|PubMed:19538957, ECO:0000269\|PubMed:2294010, ECO:0000269\|PubMed:23769672, ECO:0000269\|PubMed:23990668, ECO:0000269\|PubMed:26045166, ECO:0000269\|PubMed:28332555, ECO:0000269\|PubMed:29719251, ECO:0000269\|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269\|PubMed:15098107, ECO:0000269\|PubMed:28053106, ECO:0000269\|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269\|PubMed:20484814, ECO:0000269\|PubMed:24355926, ECO:0000269\|PubMed:32487760}.
P11055	MYH3	T1374	ochoa	Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE)	Muscle contraction.
P12882	MYH1	T1377	ochoa	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250\|UniProtKB:Q5SX40}.
P12882	MYH1	T1517	ochoa	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250\|UniProtKB:Q5SX40}.
P12883	MYH7	T1373	ochoa	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305\|PubMed:26150528, ECO:0000305\|PubMed:26246073}.
P13533	MYH6	T1375	ochoa	Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)	Muscle contraction.
P13535	MYH8	T1376	ochoa	Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)	Muscle contraction.
P15311	EZR	T533	ochoa	Ezrin (Cytovillin) (Villin-2) (p81)	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269\|PubMed:17881735, ECO:0000269\|PubMed:18270268, ECO:0000269\|PubMed:19111582}.
P16989	YBX3	T140	ochoa	Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)	Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}.
P17066	HSPA6	T504	ochoa	Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B') (Heat shock protein family A member 6)	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). {ECO:0000303\|PubMed:26865365}.
P17936	IGFBP3	T197	ochoa	Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)	Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028). {ECO:0000269\|PubMed:10874028, ECO:0000269\|PubMed:15371331, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19556345, ECO:0000269\|PubMed:19623253, ECO:0000269\|PubMed:19952275, ECO:0000269\|PubMed:20353938}.
P19447	ERCC3	T232	ochoa	General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)	ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity (PubMed:27193682, PubMed:33902107). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex (PubMed:10024882, PubMed:17466626, PubMed:8157004, PubMed:8465201). When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor (PubMed:10024882, PubMed:17466626). In transcription, TFIIH has an essential role in transcription initiation (PubMed:30894545, PubMed:8157004). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (PubMed:8157004). The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:17466626, PubMed:2111438, PubMed:8157004). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA (PubMed:31253769, PubMed:33902107). XPA retains XPB/ERCC3 at the 5' end of a DNA bubble (mimicking DNA damage) (PubMed:31253769). {ECO:0000269\|PubMed:10024882, ECO:0000269\|PubMed:17466626, ECO:0000269\|PubMed:30894545, ECO:0000269\|PubMed:31253769, ECO:0000269\|PubMed:33902107, ECO:0000269\|PubMed:7724549, ECO:0000269\|PubMed:8157004, ECO:0000269\|PubMed:8663148, ECO:0000305\|PubMed:8465201}.
P25054	APC	T2626	ochoa	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250\|UniProtKB:Q61315, ECO:0000269\|PubMed:10947987, ECO:0000269\|PubMed:17293347, ECO:0000269\|PubMed:17599059, ECO:0000269\|PubMed:19151759, ECO:0000269\|PubMed:19893577, ECO:0000269\|PubMed:20937854}.
P25205	MCM3	T163	ochoa	DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)	Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269\|PubMed:32453425, ECO:0000269\|PubMed:34694004, ECO:0000269\|PubMed:34700328, ECO:0000269\|PubMed:35585232, ECO:0000305\|PubMed:35585232}.
P28370	SMARCA1	T690	ochoa	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1) (EC 3.6.4.-) (Global transcription activator SNF2L1) (Nucleosome-remodeling factor subunit SNF2L) (SNF2L) (SNF2 related chromatin remodeling ATPase 1)	[Isoform 1]: ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:14609955, PubMed:15310751, PubMed:15640247). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:15310751, PubMed:15640247, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). May promote neurite outgrowth (PubMed:14609955). May be involved in the development of luteal cells (PubMed:16740656). Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps (PubMed:39413208). {ECO:0000269\|PubMed:14609955, ECO:0000269\|PubMed:15310751, ECO:0000269\|PubMed:15640247, ECO:0000269\|PubMed:16740656, ECO:0000269\|PubMed:28801535, ECO:0000269\|PubMed:39413208}.; FUNCTION: [Isoform 2]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535). Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751). {ECO:0000269\|PubMed:15310751, ECO:0000269\|PubMed:28801535}.
P29317	EPHA2	T593	ochoa	Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269\|PubMed:10655584, ECO:0000269\|PubMed:16236711, ECO:0000269\|PubMed:18339848, ECO:0000269\|PubMed:19573808, ECO:0000269\|PubMed:20679435, ECO:0000269\|PubMed:20861311, ECO:0000269\|PubMed:23358419, ECO:0000269\|PubMed:26158630, ECO:0000269\|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269\|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269\|PubMed:37146061}.
P30566	ADSL	T239	ochoa	Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)	Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. {ECO:0000269\|PubMed:10888601}.
P31350	RRM2	T33	ochoa\|psp	Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
P42566	EPS15	T367	ochoa	Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)	Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:16903783, ECO:0000269\|PubMed:18362181, ECO:0000269\|PubMed:19458185, ECO:0000269\|PubMed:22648170}.
P42684	ABL2	T599	ochoa	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)	Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). {ECO:0000250\|UniProtKB:Q4JIM5, ECO:0000269\|PubMed:15735735, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:18945674}.
P45985	MAP2K4	T98	ochoa	Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269\|PubMed:7716521}.
P46013	MKI67	T1347	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T1691	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T2781	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46013	MKI67	T2836	ochoa	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250\|UniProtKB:E9PVX6, ECO:0000269\|PubMed:10878551, ECO:0000269\|PubMed:24867636, ECO:0000269\|PubMed:27362226, ECO:0000269\|PubMed:28935370, ECO:0000269\|PubMed:32879492, ECO:0000269\|PubMed:35513709, ECO:0000269\|PubMed:39153474}.
P46100	ATRX	T670	ochoa	Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)	Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269\|PubMed:12953102, ECO:0000269\|PubMed:14990586, ECO:0000269\|PubMed:20504901, ECO:0000269\|PubMed:20651253, ECO:0000269\|PubMed:21029860, ECO:0000269\|PubMed:22391447, ECO:0000269\|PubMed:22829774, ECO:0000269\|PubMed:24500201, ECO:0000269\|PubMed:27029610}.
P49792	RANBP2	T2289	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49792	RANBP2	T2602	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P51178	PLCD1	T193	ochoa	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:9188725). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PubMed:7890667, PubMed:9188725). {ECO:0000250\|UniProtKB:Q8R3B1, ECO:0000269\|PubMed:7890667, ECO:0000269\|PubMed:9188725}.
P52594	AGFG1	T323	ochoa	Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein)	Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269\|PubMed:10613896, ECO:0000269\|PubMed:14701878, ECO:0000269\|PubMed:15749819}.
P53618	COPB1	T523	ochoa	Coatomer subunit beta (Beta-coat protein) (Beta-COP)	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. {ECO:0000250, ECO:0000269\|PubMed:18385291, ECO:0000269\|PubMed:18725938, ECO:0000269\|PubMed:19364919, ECO:0000269\|PubMed:20056612}.
P54132	BLM	T283	ochoa	RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)	ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288, PubMed:34606619). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030). Binds single-stranded DNA (ssDNA), forked duplex DNA and Holliday junction DNA (PubMed:20639533, PubMed:24257077, PubMed:25901030). Unwinds G-quadruplex DNA; unwinding occurs in the 3'-5' direction and requires a 3' single-stranded end of at least 7 nucleotides (PubMed:18426915, PubMed:9765292). Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292). Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030). Recruited by the KHDC3L-OOEP scaffold to DNA replication forks where it is retained by TRIM25 ubiquitination, it thereby promotes the restart of stalled replication forks (By similarity). {ECO:0000250\|UniProtKB:O88700, ECO:0000269\|PubMed:12019152, ECO:0000269\|PubMed:18426915, ECO:0000269\|PubMed:20639533, ECO:0000269\|PubMed:21325134, ECO:0000269\|PubMed:23509288, ECO:0000269\|PubMed:24257077, ECO:0000269\|PubMed:24816114, ECO:0000269\|PubMed:25901030, ECO:0000269\|PubMed:34606619, ECO:0000269\|PubMed:9388193, ECO:0000269\|PubMed:9765292}.; FUNCTION: (Microbial infection) Eliminates nuclear HIV-1 cDNA, thereby suppressing immune sensing and proviral hyper-integration. {ECO:0000269\|PubMed:32690953}.
P60709	ACTB	T201	ochoa	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250\|UniProtKB:Q6QAQ1, ECO:0000269\|PubMed:25255767, ECO:0000269\|PubMed:29581253, ECO:0000269\|PubMed:29925947, ECO:0000269\|PubMed:38609661, ECO:0000269\|PubMed:39321809}.
P62805	H4C1	T31	ochoa	Histone H4	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P63261	ACTG1	T201	ochoa	Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250\|UniProtKB:P63260, ECO:0000305\|PubMed:29581253}.
P67809	YBX1	T108	ochoa	Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)	DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250\|UniProtKB:P62960, ECO:0000250\|UniProtKB:Q28618, ECO:0000269\|PubMed:10817758, ECO:0000269\|PubMed:11698476, ECO:0000269\|PubMed:12604611, ECO:0000269\|PubMed:14718551, ECO:0000269\|PubMed:18809583, ECO:0000269\|PubMed:19029303, ECO:0000269\|PubMed:19483673, ECO:0000269\|PubMed:19561594, ECO:0000269\|PubMed:27559612, ECO:0000269\|PubMed:28341602, ECO:0000269\|PubMed:29073095, ECO:0000269\|PubMed:29712925, ECO:0000269\|PubMed:31358969, ECO:0000269\|PubMed:8188694}.
P78347	GTF2I	T202	ochoa	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)	Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269\|PubMed:10373551, ECO:0000269\|PubMed:11373296, ECO:0000269\|PubMed:16738337}.
P99999	CYCS	T50	ochoa	Cytochrome c	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Q02952	AKAP12	T1760	ochoa\|psp	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q10570	CPSF1	T1042	ochoa	Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250\|UniProtKB:A0A0R4IC37, ECO:0000269\|PubMed:14749727}.
Q14103	HNRNPD	T193	ochoa\|psp	Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)	Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000269\|PubMed:10080887, ECO:0000269\|PubMed:11051545, ECO:0000269\|PubMed:24423872}.
Q14790	CASP8	T263	psp	Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). {ECO:0000250\|UniProtKB:O89110, ECO:0000269\|PubMed:16916640, ECO:0000269\|PubMed:18216014, ECO:0000269\|PubMed:23516580, ECO:0000269\|PubMed:27109099, ECO:0000269\|PubMed:31827280, ECO:0000269\|PubMed:31827281, ECO:0000269\|PubMed:32929201, ECO:0000269\|PubMed:34012073, ECO:0000269\|PubMed:35338844, ECO:0000269\|PubMed:35446120, ECO:0000269\|PubMed:8681376, ECO:0000269\|PubMed:8681377, ECO:0000269\|PubMed:8755496, ECO:0000269\|PubMed:8962078, ECO:0000269\|PubMed:9006941, ECO:0000269\|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305\|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305\|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269\|PubMed:12010809, ECO:0000305\|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305\|PubMed:8681376}.
Q14839	CHD4	T1653	ochoa	Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)	ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). {ECO:0000250\|UniProtKB:Q6PDQ2, ECO:0000269\|PubMed:16428440, ECO:0000269\|PubMed:17626165, ECO:0000269\|PubMed:25593309, ECO:0000269\|PubMed:28977666, ECO:0000269\|PubMed:32543371, ECO:0000269\|PubMed:9804427}.
Q15025	TNIP1	T406	ochoa	TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)	Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection. {ECO:0000269\|PubMed:12220502, ECO:0000269\|PubMed:16684768, ECO:0000269\|PubMed:17016622, ECO:0000269\|PubMed:17632516, ECO:0000269\|PubMed:20010814, ECO:0000269\|PubMed:21885437}.
Q16543	CDC37	T131	psp	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]	Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269\|PubMed:23569206, ECO:0000269\|PubMed:8666233}.
Q32MZ4	LRRFIP1	T596	ochoa	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein)	Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269\|PubMed:10364563, ECO:0000269\|PubMed:14522076, ECO:0000269\|PubMed:16199883, ECO:0000269\|PubMed:19265123, ECO:0000269\|PubMed:9705290}.
Q58FG0	HSP90AA5P	T180	ochoa	Putative heat shock protein HSP 90-alpha A5 (Heat shock protein 90-alpha E) (Heat shock protein 90Ae)	Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q5QJE6	DNTTIP2	T87	ochoa	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269\|PubMed:12786946, ECO:0000269\|PubMed:15047147, ECO:0000269\|PubMed:34516797}.
Q5SW79	CEP170	T487	ochoa	Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)	Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269\|PubMed:15616186, ECO:0000269\|PubMed:28422092}.
Q5T3J3	LRIF1	T732	ochoa	Ligand-dependent nuclear receptor-interacting factor 1 (HP1-binding protein enriched in inactive X chromosome protein 1) (HBiX1) (Receptor-interacting factor 1)	Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211). Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133). {ECO:0000269\|PubMed:17455211, ECO:0000269\|PubMed:23542155, ECO:0000269\|PubMed:32467133}.
Q5VZL5	ZMYM4	T1070	ochoa	Zinc finger MYM-type protein 4 (Zinc finger protein 262)	Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269\|PubMed:21834987}.
Q6NXE6	ARMC6	T88	ochoa	Armadillo repeat-containing protein 6	None
Q6UB99	ANKRD11	T410	ochoa	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)	Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250\|UniProtKB:E9Q4F7, ECO:0000269\|PubMed:15184363, ECO:0000269\|PubMed:25556659}.
Q6UXG2	ELAPOR1	T989	ochoa	Endosome/lysosome-associated apoptosis and autophagy regulator 1 (Estrogen-induced gene 121 protein)	May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway (PubMed:21072319). May play a role in apoptosis and cell proliferation through its interaction with HSPA5 (PubMed:26045166). {ECO:0000269\|PubMed:21072319, ECO:0000269\|PubMed:26045166}.
Q76G19	PDZD4	T662	ochoa	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein)	None
Q7Z2T5	TRMT1L	T600	ochoa	tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein)	Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269\|PubMed:39786990, ECO:0000269\|PubMed:39786998}.
Q7Z3J3	RGPD4	T1314	ochoa	RanBP2-like and GRIP domain-containing protein 4	None
Q7Z6Z7	HUWE1	T1927	ochoa	E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250\|UniProtKB:P51593, ECO:0000250\|UniProtKB:Q7TMY8, ECO:0000269\|PubMed:15567145, ECO:0000269\|PubMed:15767685, ECO:0000269\|PubMed:15989956, ECO:0000269\|PubMed:15989957, ECO:0000269\|PubMed:17567951, ECO:0000269\|PubMed:18488021, ECO:0000269\|PubMed:19037095, ECO:0000269\|PubMed:19713937, ECO:0000269\|PubMed:20534529, ECO:0000269\|PubMed:26214738, ECO:0000269\|PubMed:27746020, ECO:0000269\|PubMed:30217973, ECO:0000269\|PubMed:35776542}.
Q8IX01	SUGP2	T1045	ochoa	SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)	May play a role in mRNA splicing. {ECO:0000305}.
Q8N680	ZBTB2	T456	ochoa	Zinc finger and BTB domain-containing protein 2	May be involved in transcriptional regulation.
Q8NB50	ZFP62	T102	ochoa	Zinc finger protein 62 homolog (Zfp-62)	May play a role in differentiating skeletal muscle. {ECO:0000250}.
Q8NCE2	MTMR14	T424	ochoa	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy)	Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269\|PubMed:17008356}.
Q8NEV8	EXPH5	T1824	ochoa	Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b)	May act as Rab effector protein and play a role in vesicle trafficking.
Q8TDJ6	DMXL2	T330	ochoa	DmX-like protein 2 (Rabconnectin-3)	May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250\|UniProtKB:Q8BPN8, ECO:0000269\|PubMed:11809763}.
Q8TDZ2	MICAL1	T908	ochoa	[F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains)	Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433). {ECO:0000250\|UniProtKB:Q8VDP3, ECO:0000269\|PubMed:18305261, ECO:0000269\|PubMed:21864500, ECO:0000269\|PubMed:26845023, ECO:0000269\|PubMed:28230050, ECO:0000269\|PubMed:29343822, ECO:0000269\|PubMed:32344433, ECO:0000305\|PubMed:27552051}.
Q8TEK3	DOT1L	T772	ochoa	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)	Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). {ECO:0000269\|PubMed:12123582, ECO:0000269\|PubMed:12628190}.
Q8TEU7	RAPGEF6	T1205	ochoa	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)	Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269\|PubMed:11524421, ECO:0000269\|PubMed:12581858}.
Q8WUM9	SLC20A1	T305	ochoa	Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)	Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269\|PubMed:11009570, ECO:0000269\|PubMed:16790504, ECO:0000269\|PubMed:17494632, ECO:0000269\|PubMed:19726692, ECO:0000269\|PubMed:7929240, ECO:0000269\|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269\|PubMed:12097582, ECO:0000269\|PubMed:1309898, ECO:0000269\|PubMed:2078500, ECO:0000269\|PubMed:7966619}.
Q8WW12	PCNP	T106	ochoa	PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein)	May be involved in cell cycle regulation.
Q8WYP5	AHCTF1	T1826	ochoa	Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)	Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269\|PubMed:17098863, ECO:0000269\|PubMed:17235358}.
Q96A70	AZIN2	T34	ochoa	Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p)	Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728). {ECO:0000269\|PubMed:17900240, ECO:0000269\|PubMed:20188728}.
Q96QT4	TRPM7	T1163	psp	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]	Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250\|UniProtKB:Q923J1, ECO:0000269\|PubMed:11385574, ECO:0000269\|PubMed:12887921, ECO:0000269\|PubMed:15485879, ECO:0000269\|PubMed:18365021, ECO:0000269\|PubMed:18394644, ECO:0000269\|PubMed:24316671, ECO:0000269\|PubMed:35561741, ECO:0000269\|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250\|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250\|UniProtKB:Q923J1}.
Q96T23	RSF1	T410	ochoa	Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex)	Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269\|PubMed:11788598, ECO:0000269\|PubMed:11944984, ECO:0000269\|PubMed:12972596, ECO:0000269\|PubMed:28801535}.
Q9BPX3	NCAPG	T670	ochoa	Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog)	Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269\|PubMed:11136719}.
Q9BXS9	SLC26A6	T615	ochoa	Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)	Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Also mediates intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger also provides a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Also mediates the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. {ECO:0000250\|UniProtKB:Q8CIW6, ECO:0000269\|PubMed:20501439, ECO:0000269\|PubMed:27681177}.; FUNCTION: [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. {ECO:0000269\|PubMed:15990874}.
Q9BY67	CADM1	T422	ochoa	Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)	Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12050160, PubMed:22438059). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246). {ECO:0000250\|UniProtKB:Q8R5M8, ECO:0000269\|PubMed:11279526, ECO:0000269\|PubMed:12050160, ECO:0000269\|PubMed:12234973, ECO:0000269\|PubMed:12920246, ECO:0000269\|PubMed:15811952, ECO:0000269\|PubMed:15905536, ECO:0000269\|PubMed:22438059}.; FUNCTION: [Isoform 5]: (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus. {ECO:0000269\|PubMed:37166307}.
Q9BY89	KIAA1671	T1162	ochoa	Uncharacterized protein KIAA1671	None
Q9H0A0	NAT10	T672	ochoa	RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP)	RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250\|UniProtKB:P53914, ECO:0000269\|PubMed:14592445, ECO:0000269\|PubMed:17631499, ECO:0000269\|PubMed:18082603, ECO:0000269\|PubMed:19303003, ECO:0000269\|PubMed:25411247, ECO:0000269\|PubMed:25653167, ECO:0000269\|PubMed:26882543, ECO:0000269\|PubMed:27993683, ECO:0000269\|PubMed:30165671, ECO:0000269\|PubMed:30449621, ECO:0000269\|PubMed:31722219, ECO:0000269\|PubMed:34516797, ECO:0000269\|PubMed:35679869}.
Q9H0X9	OSBPL5	T332	ochoa	Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1)	Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269\|PubMed:17428193, ECO:0000269\|PubMed:21220512, ECO:0000269\|PubMed:23934110, ECO:0000269\|PubMed:26206935}.
Q9H4A6	GOLPH3	T148	psp	Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS)	Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269\|PubMed:16263763, ECO:0000269\|PubMed:19553991, ECO:0000269\|PubMed:19837035, ECO:0000269\|PubMed:22745132, ECO:0000269\|PubMed:23027862, ECO:0000269\|PubMed:23345592, ECO:0000269\|PubMed:23500462}.
Q9H501	ESF1	T630	ochoa	ESF1 homolog (ABT1-associated protein)	May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.
Q9H6N6	MYH16	T536	ochoa	Putative uncharacterized protein MYH16 (Myosin heavy chain 16 pseudogene) (myosin heavy polypeptide 5)	Has most probably lost the function in masticatory muscles contraction suspected for its homologs in dog (AC F1PT61) and apes. {ECO:0000303\|PubMed:15042088}.
Q9H814	PHAX	T349	ochoa	Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein)	A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269\|PubMed:15574332, ECO:0000269\|PubMed:15574333}.
Q9NQS1	AVEN	T307	ochoa	Cell death regulator Aven	Protects against apoptosis mediated by Apaf-1.
Q9NSV4	DIAPH3	T1144	ochoa	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2)	Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250\|UniProtKB:Q9Z207}.
Q9NWH9	SLTM	T246	ochoa	SAFB-like transcription modulator (Modulator of estrogen-induced transcription)	When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}.
Q9P2T1	GMPR2	T187	ochoa	GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). {ECO:0000255\|HAMAP-Rule:MF_03195, ECO:0000269\|PubMed:12009299, ECO:0000269\|PubMed:12669231, ECO:0000269\|PubMed:16359702, ECO:0000269\|PubMed:22037469}.
Q9UBU7	DBF4	T273	ochoa\|psp	Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1)	Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269\|PubMed:10373557, ECO:0000269\|PubMed:10523313, ECO:0000269\|PubMed:17062569}.
Q9UEY8	ADD3	T411	ochoa	Gamma-adducin (Adducin-like protein 70)	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250\|UniProtKB:Q62847, ECO:0000250\|UniProtKB:Q9QYB5, ECO:0000269\|PubMed:23836506, ECO:0000305}.
Q9UEY8	ADD3	T654	ochoa	Gamma-adducin (Adducin-like protein 70)	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity). {ECO:0000250\|UniProtKB:Q62847, ECO:0000250\|UniProtKB:Q9QYB5, ECO:0000269\|PubMed:23836506, ECO:0000305}.
Q9UJX4	ANAPC5	T178	ochoa	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269\|PubMed:18485873, ECO:0000269\|PubMed:29033132}.
Q9UKA4	AKAP11	T1140	ochoa\|psp	A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11)	Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Q9UKX2	MYH2	T1379	ochoa	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250\|UniProtKB:P12883}.
Q9UKX2	MYH2	T1519	ochoa	Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)	Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250\|UniProtKB:P12883}.
Q9UKX3	MYH13	T1377	ochoa	Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)	Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269\|PubMed:23908353}.
Q9UPQ7	PDZRN3	T959	ochoa	E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)	E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000250\|UniProtKB:Q69ZS0}.
Q9Y2T7	YBX2	T143	ochoa	Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog)	Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250\|UniProtKB:Q9Z2C8}.
Q9Y2Z0	SUGT1	T284	ochoa	Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)	May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Q9Y4J8	DTNA	T643	ochoa	Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3)	May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Q9Y623	MYH4	T1377	ochoa	Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)	Muscle contraction.
Q9Y678	COPG1	T739	ochoa	Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269\|PubMed:20674546}.
Q9Y6D5	ARFGEF2	T589	ochoa	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)	Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269\|PubMed:12051703, ECO:0000269\|PubMed:12571360, ECO:0000269\|PubMed:15385626, ECO:0000269\|PubMed:16477018, ECO:0000269\|PubMed:17276987, ECO:0000269\|PubMed:18625701, ECO:0000269\|PubMed:20360857}.
P14625	HSP90B1	T171	Sugiyama	Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)	ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269\|PubMed:11584270, ECO:0000269\|PubMed:23572575, ECO:0000269\|PubMed:32272059, ECO:0000269\|PubMed:39509507}.
Q9Y2B0	CNPY2	T100	Sugiyama	Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4)	Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
P07900	HSP90AA1	T467	Sugiyama	Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269\|PubMed:11274138, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:12526792, ECO:0000269\|PubMed:15577939, ECO:0000269\|PubMed:15937123, ECO:0000269\|PubMed:20628368, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:25609812, ECO:0000269\|PubMed:27353360, ECO:0000269\|PubMed:29127155, ECO:0000303\|PubMed:25973397, ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305\|PubMed:22066472}.
P08238	HSP90AB1	T487	Sugiyama	Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)	Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269\|PubMed:16478993, ECO:0000269\|PubMed:18239673, ECO:0000269\|PubMed:19696785, ECO:0000269\|PubMed:20353823, ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:32272059, ECO:0000303\|PubMed:25973397, ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269\|PubMed:21949862, ECO:0000305\|PubMed:22066472}.
Q58FF8	HSP90AB2P	T263	Sugiyama	Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb)	Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
O15446	POLR1G	T435	Sugiyama	DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49)	Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269\|PubMed:34671025, ECO:0000269\|PubMed:34887565, ECO:0000269\|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269\|PubMed:10373416}.
Q99613	EIF3C	T157	Sugiyama	Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255\|HAMAP-Rule:MF_03002, ECO:0000269\|PubMed:17581632, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.
P61163	ACTR1A	T248	Sugiyama	Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)	Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250\|UniProtKB:F2Z5G5}.
O60264	SMARCA5	T79	Sugiyama	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)	ATPase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (PubMed:12972596, PubMed:28801535). Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:10880450, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:23911928, PubMed:28801535). Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535). Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535). The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:15543136, PubMed:28801535). The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (By similarity). Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure (PubMed:11980720, PubMed:15543136). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (By similarity). Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). {ECO:0000250\|UniProtKB:Q91ZW3, ECO:0000269\|PubMed:10880450, ECO:0000269\|PubMed:11980720, ECO:0000269\|PubMed:12198550, ECO:0000269\|PubMed:12434153, ECO:0000269\|PubMed:12972596, ECO:0000269\|PubMed:14759371, ECO:0000269\|PubMed:15543136, ECO:0000269\|PubMed:16603771, ECO:0000269\|PubMed:23911928, ECO:0000269\|PubMed:28801535}.
P20042	EIF2S2	T163	Sugiyama	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta)	Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250\|UniProtKB:P05198, ECO:0000269\|PubMed:31836389}.
P00813	ADA	T242	Sugiyama	Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)	Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:16670267, PubMed:23193172, PubMed:26166670, PubMed:8452534, PubMed:9361033). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (PubMed:26038697). {ECO:0000250\|UniProtKB:P03958, ECO:0000250\|UniProtKB:P56658, ECO:0000269\|PubMed:11772392, ECO:0000269\|PubMed:15016824, ECO:0000269\|PubMed:16670267, ECO:0000269\|PubMed:20959412, ECO:0000269\|PubMed:21919946, ECO:0000269\|PubMed:23193172, ECO:0000269\|PubMed:26038697, ECO:0000269\|PubMed:26166670, ECO:0000269\|PubMed:8452534, ECO:0000269\|PubMed:9361033}.
Q16543	CDC37	T243	Sugiyama	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]	Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269\|PubMed:23569206, ECO:0000269\|PubMed:8666233}.
Q9UG63	ABCF2	T35	Sugiyama	ATP-binding cassette sub-family F member 2 (Iron-inhibited ABC transporter 2)	None
Q9Y4L1	HYOU1	T969	Sugiyama	Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)	Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250\|UniProtKB:Q9JKR6, ECO:0000269\|PubMed:10037731}.
Q00987	MDM2	T365	PSP	E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250\|UniProtKB:P23804, ECO:0000269\|PubMed:12821780, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:15195100, ECO:0000269\|PubMed:15632057, ECO:0000269\|PubMed:16337594, ECO:0000269\|PubMed:17290220, ECO:0000269\|PubMed:19098711, ECO:0000269\|PubMed:19219073, ECO:0000269\|PubMed:19837670, ECO:0000269\|PubMed:19965871, ECO:0000269\|PubMed:20173098, ECO:0000269\|PubMed:20385133, ECO:0000269\|PubMed:20858735, ECO:0000269\|PubMed:22128911, ECO:0000269\|PubMed:29681526, ECO:0000269\|PubMed:30879903}.
O60234	GMFG	T118	Sugiyama	Glia maturation factor gamma (GMF-gamma)	None
P60983	GMFB	T118	Sugiyama	Glia maturation factor beta (GMF-beta)	This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
Q12792	TWF1	T304	Sugiyama	Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)	Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}.
Q9H788	SH2D4A	T142	Sugiyama	SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)	Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269\|PubMed:18641339, ECO:0000269\|PubMed:19712589}.
P09972	ALDOC	T52	Sugiyama	Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase)	None
Q05655	PRKCD	T58	Sugiyama	Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses (PubMed:21406692, PubMed:21810427). Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis (PubMed:21406692, PubMed:21810427). In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 (PubMed:21406692, PubMed:21810427). In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 (PubMed:21406692, PubMed:21810427). In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 (PubMed:15774464). Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways (PubMed:19801500). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA (PubMed:11748588). In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation (PubMed:16940418). Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release (PubMed:19587372). Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (PubMed:11877440). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment (PubMed:18285462). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (PubMed:12649167). Phosphorylates SMPD1 which induces SMPD1 secretion (PubMed:17303575). {ECO:0000250\|UniProtKB:P28867, ECO:0000269\|PubMed:11748588, ECO:0000269\|PubMed:11877440, ECO:0000269\|PubMed:12649167, ECO:0000269\|PubMed:15774464, ECO:0000269\|PubMed:16940418, ECO:0000269\|PubMed:17303575, ECO:0000269\|PubMed:18285462, ECO:0000269\|PubMed:19587372, ECO:0000269\|PubMed:19801500, ECO:0000303\|PubMed:21406692, ECO:0000303\|PubMed:21810427}.
P19338	NCL	T487	Sugiyama	Nucleolin (Protein C23)	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. {ECO:0000269\|PubMed:10393184}.
P22234	PAICS	T40	Sugiyama	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)]	Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269\|PubMed:17224163, ECO:0000269\|PubMed:2183217, ECO:0000269\|PubMed:31600779}.
P49756	RBM25	T187	Sugiyama	RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)	RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269\|PubMed:18663000, ECO:0000269\|PubMed:21859973}.
Q9GZZ9	UBA5	T386	Sugiyama	Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1)	E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250\|UniProtKB:Q8VE47, ECO:0000269\|PubMed:15071506, ECO:0000269\|PubMed:18442052, ECO:0000269\|PubMed:20368332, ECO:0000269\|PubMed:25219498, ECO:0000269\|PubMed:26929408, ECO:0000269\|PubMed:27545674, ECO:0000269\|PubMed:27545681, ECO:0000269\|PubMed:27653677, ECO:0000269\|PubMed:29295865, ECO:0000269\|PubMed:30412706, ECO:0000269\|PubMed:30626644, ECO:0000269\|PubMed:32160526, ECO:0000269\|PubMed:34588452, ECO:0000269\|PubMed:35394863}.
Q9NWZ3	IRAK4	T223	Sugiyama	Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269\|PubMed:11960013, ECO:0000269\|PubMed:12538665, ECO:0000269\|PubMed:15084582, ECO:0000269\|PubMed:17217339, ECO:0000269\|PubMed:17337443, ECO:0000269\|PubMed:17878374, ECO:0000269\|PubMed:17997719, ECO:0000269\|PubMed:20400509, ECO:0000269\|PubMed:24316379}.
P35579	MYH9	T309	Sugiyama	Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250\|UniProtKB:Q8VDD5, ECO:0000269\|PubMed:16707441, ECO:0000269\|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269\|PubMed:20944748, ECO:0000269\|PubMed:39048823}.
Q7KZF4	SND1	T98	Sugiyama	Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)	Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250\|UniProtKB:Q78PY7, ECO:0000269\|PubMed:12234934, ECO:0000269\|PubMed:18453631, ECO:0000269\|PubMed:28546213, ECO:0000269\|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269\|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269\|PubMed:37794589}.
O76021	RSL1D1	T328	Sugiyama	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269\|PubMed:18678645, ECO:0000269\|PubMed:22419112}.

Download

reactome_id	name	p	-log10_p
R-HSA-3371571	HSF1-dependent transactivation	3.219647e-15	14.492
R-HSA-3371556	Cellular response to heat stress	6.639134e-14	13.178
R-HSA-3371568	Attenuation phase	1.302292e-13	12.885
R-HSA-1640170	Cell Cycle	1.172396e-13	12.931
R-HSA-69278	Cell Cycle, Mitotic	5.158096e-13	12.288
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	8.935075e-12	11.049
R-HSA-69620	Cell Cycle Checkpoints	2.795564e-11	10.554
R-HSA-3371511	HSF1 activation	1.253775e-10	9.902
R-HSA-774815	Nucleosome assembly	4.931057e-10	9.307
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	4.931057e-10	9.307
R-HSA-3214847	HATs acetylate histones	5.200015e-10	9.284
R-HSA-2262752	Cellular responses to stress	7.188825e-10	9.143
R-HSA-68886	M Phase	1.802340e-09	8.744
R-HSA-69481	G2/M Checkpoints	1.822397e-09	8.739
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	2.208603e-09	8.656
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	4.687084e-09	8.329
R-HSA-3214815	HDACs deacetylate histones	7.791441e-09	8.108
R-HSA-73728	RNA Polymerase I Promoter Opening	1.188154e-08	7.925
R-HSA-68867	Assembly of the pre-replicative complex	1.240386e-08	7.906
R-HSA-8953897	Cellular responses to stimuli	1.352180e-08	7.869
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	2.288032e-08	7.641
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	2.559440e-08	7.592
R-HSA-75153	Apoptotic execution phase	2.570011e-08	7.590
R-HSA-9821993	Replacement of protamines by nucleosomes in the male pronucleus	3.076042e-08	7.512
R-HSA-3247509	Chromatin modifying enzymes	4.439727e-08	7.353
R-HSA-69002	DNA Replication Pre-Initiation	6.086759e-08	7.216
R-HSA-171306	Packaging Of Telomere Ends	9.100356e-08	7.041
R-HSA-68616	Assembly of the ORC complex at the origin of replication	9.035272e-08	7.044
R-HSA-69473	G2/M DNA damage checkpoint	9.728620e-08	7.012
R-HSA-69306	DNA Replication	1.036959e-07	6.984
R-HSA-68875	Mitotic Prophase	1.110491e-07	6.954
R-HSA-73886	Chromosome Maintenance	1.278120e-07	6.893
R-HSA-73854	RNA Polymerase I Promoter Clearance	1.418642e-07	6.848
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	1.393836e-07	6.856
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	1.641243e-07	6.785
R-HSA-5334118	DNA methylation	1.764411e-07	6.753
R-HSA-4839726	Chromatin organization	1.878749e-07	6.726
R-HSA-73864	RNA Polymerase I Transcription	2.045410e-07	6.689
R-HSA-2559580	Oxidative Stress Induced Senescence	2.622409e-07	6.581
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	3.741161e-07	6.427
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	4.169766e-07	6.380
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected ...	4.405096e-07	6.356
R-HSA-1500931	Cell-Cell communication	4.885760e-07	6.311
R-HSA-73772	RNA Polymerase I Promoter Escape	5.795386e-07	6.237
R-HSA-1221632	Meiotic synapsis	7.168261e-07	6.145
R-HSA-9670095	Inhibition of DNA recombination at telomere	8.150566e-07	6.089
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	9.208687e-07	6.036
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected ...	1.014073e-06	5.994
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	1.039484e-06	5.983
R-HSA-212300	PRC2 methylates histones and DNA	1.699842e-06	5.770
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	1.923988e-06	5.716
R-HSA-427359	SIRT1 negatively regulates rRNA expression	2.177375e-06	5.662
R-HSA-8852135	Protein ubiquitination	2.148495e-06	5.668
R-HSA-110331	Cleavage of the damaged purine	2.177375e-06	5.662
R-HSA-912446	Meiotic recombination	2.296213e-06	5.639
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	2.356536e-06	5.628
R-HSA-111465	Apoptotic cleavage of cellular proteins	2.726655e-06	5.564
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	2.836132e-06	5.547
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	2.805906e-06	5.552
R-HSA-73927	Depurination	2.770431e-06	5.557
R-HSA-8878171	Transcriptional regulation by RUNX1	3.129391e-06	5.505
R-HSA-5693538	Homology Directed Repair	3.450513e-06	5.462
R-HSA-9764560	Regulation of CDH1 Gene Transcription	3.825351e-06	5.417
R-HSA-2299718	Condensation of Prophase Chromosomes	3.970207e-06	5.401
R-HSA-212165	Epigenetic regulation of gene expression	4.562956e-06	5.341
R-HSA-427413	NoRC negatively regulates rRNA expression	4.510082e-06	5.346
R-HSA-5578749	Transcriptional regulation by small RNAs	5.302967e-06	5.275
R-HSA-9821002	Chromatin modifications during the maternal to zygotic transition (MZT)	5.497562e-06	5.260
R-HSA-5693607	Processing of DNA double-strand break ends	5.523050e-06	5.258
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	5.960288e-06	5.225
R-HSA-157579	Telomere Maintenance	6.163757e-06	5.210
R-HSA-2559583	Cellular Senescence	6.177037e-06	5.209
R-HSA-73884	Base Excision Repair	6.375619e-06	5.195
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	7.390144e-06	5.131
R-HSA-5689880	Ub-specific processing proteases	8.758793e-06	5.058
R-HSA-9764265	Regulation of CDH1 Expression and Function	8.758793e-06	5.058
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	8.758793e-06	5.058
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	8.582404e-06	5.066
R-HSA-110329	Cleavage of the damaged pyrimidine	8.436805e-06	5.074
R-HSA-73928	Depyrimidination	8.436805e-06	5.074
R-HSA-1500620	Meiosis	9.898113e-06	5.004
R-HSA-5693606	DNA Double Strand Break Response	9.467728e-06	5.024
R-HSA-9710421	Defective pyroptosis	1.036950e-05	4.984
R-HSA-9842860	Regulation of endogenous retroelements	1.173946e-05	4.930
R-HSA-390450	Folding of actin by CCT/TriC	1.203627e-05	4.920
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins	1.518560e-05	4.819
R-HSA-422475	Axon guidance	1.633115e-05	4.787
R-HSA-9616222	Transcriptional regulation of granulopoiesis	1.691600e-05	4.772
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	1.726033e-05	4.763
R-HSA-373753	Nephrin family interactions	1.728537e-05	4.762
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	1.770432e-05	4.752
R-HSA-8953854	Metabolism of RNA	2.027667e-05	4.693
R-HSA-109581	Apoptosis	2.120590e-05	4.674
R-HSA-5693532	DNA Double-Strand Break Repair	2.498974e-05	4.602
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	2.504303e-05	4.601
R-HSA-418990	Adherens junctions interactions	2.563179e-05	4.591
R-HSA-446728	Cell junction organization	2.831091e-05	4.548
R-HSA-5688426	Deubiquitination	2.988574e-05	4.525
R-HSA-9675108	Nervous system development	4.977886e-05	4.303
R-HSA-421270	Cell-cell junction organization	5.178112e-05	4.286
R-HSA-5357801	Programmed Cell Death	5.529728e-05	4.257
R-HSA-9645723	Diseases of programmed cell death	5.817362e-05	4.235
R-HSA-211000	Gene Silencing by RNA	7.432329e-05	4.129
R-HSA-73929	Base-Excision Repair, AP Site Formation	7.489730e-05	4.126
R-HSA-9665230	Drug resistance in ERBB2 KD mutants	9.108503e-05	4.041
R-HSA-9652282	Drug-mediated inhibition of ERBB2 signaling	9.108503e-05	4.041
R-HSA-9665233	Resistance of ERBB2 KD mutants to trastuzumab	9.108503e-05	4.041
R-HSA-9665246	Resistance of ERBB2 KD mutants to neratinib	9.108503e-05	4.041
R-HSA-9665251	Resistance of ERBB2 KD mutants to lapatinib	9.108503e-05	4.041
R-HSA-9665249	Resistance of ERBB2 KD mutants to afatinib	9.108503e-05	4.041
R-HSA-9665244	Resistance of ERBB2 KD mutants to sapitinib	9.108503e-05	4.041
R-HSA-9665245	Resistance of ERBB2 KD mutants to tesevatinib	9.108503e-05	4.041
R-HSA-9665250	Resistance of ERBB2 KD mutants to AEE788	9.108503e-05	4.041
R-HSA-9665737	Drug resistance in ERBB2 TMD/JMD mutants	9.108503e-05	4.041
R-HSA-9665247	Resistance of ERBB2 KD mutants to osimertinib	9.108503e-05	4.041
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	8.070236e-05	4.093
R-HSA-1912408	Pre-NOTCH Transcription and Translation	8.361301e-05	4.078
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati...	1.019833e-04	3.991
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	1.126402e-04	3.948
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	1.238539e-04	3.907
R-HSA-9020591	Interleukin-12 signaling	1.268896e-04	3.897
R-HSA-8869496	TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif...	1.863527e-04	3.730
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	2.091564e-04	3.680
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	2.091564e-04	3.680
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	2.091564e-04	3.680
R-HSA-9018519	Estrogen-dependent gene expression	2.493581e-04	3.603
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	2.504831e-04	3.601
R-HSA-389957	Prefoldin mediated transfer of substrate to CCT/TriC	3.035123e-04	3.518
R-HSA-1474165	Reproduction	3.546323e-04	3.450
R-HSA-74160	Gene expression (Transcription)	3.675225e-04	3.435
R-HSA-1912422	Pre-NOTCH Expression and Processing	3.867422e-04	3.413
R-HSA-8868773	rRNA processing in the nucleus and cytosol	4.504531e-04	3.346
R-HSA-400685	Sema4D in semaphorin signaling	4.692354e-04	3.329
R-HSA-72689	Formation of a pool of free 40S subunits	4.859972e-04	3.313
R-HSA-176187	Activation of ATR in response to replication stress	4.721653e-04	3.326
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	4.827536e-04	3.316
R-HSA-447115	Interleukin-12 family signaling	5.085899e-04	3.294
R-HSA-157118	Signaling by NOTCH	5.825504e-04	3.235
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	6.617797e-04	3.179
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	6.617797e-04	3.179
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	6.755920e-04	3.170
R-HSA-3928663	EPHA-mediated growth cone collapse	7.017440e-04	3.154
R-HSA-9841251	Mitochondrial unfolded protein response (UPRmt)	7.017440e-04	3.154
R-HSA-201681	TCF dependent signaling in response to WNT	7.237950e-04	3.140
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	8.248330e-04	3.084
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	8.437036e-04	3.074
R-HSA-2682334	EPH-Ephrin signaling	9.294106e-04	3.032
R-HSA-156842	Eukaryotic Translation Elongation	9.294106e-04	3.032
R-HSA-397014	Muscle contraction	1.021789e-03	2.991
R-HSA-373755	Semaphorin interactions	9.261824e-04	3.033
R-HSA-140342	Apoptosis induced DNA fragmentation	9.739191e-04	3.011
R-HSA-9816359	Maternal to zygotic transition (MZT)	1.084960e-03	2.965
R-HSA-5619507	Activation of HOX genes during differentiation	1.231962e-03	2.909
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	1.231962e-03	2.909
R-HSA-68882	Mitotic Anaphase	1.293423e-03	2.888
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	1.304539e-03	2.885
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	1.349617e-03	2.870
R-HSA-2555396	Mitotic Metaphase and Anaphase	1.370353e-03	2.863
R-HSA-68877	Mitotic Prometaphase	1.371339e-03	2.863
R-HSA-194138	Signaling by VEGF	1.373177e-03	2.862
R-HSA-4420097	VEGFA-VEGFR2 Pathway	1.425554e-03	2.846
R-HSA-453279	Mitotic G1 phase and G1/S transition	1.428993e-03	2.845
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	1.442186e-03	2.841
R-HSA-72737	Cap-dependent Translation Initiation	1.544295e-03	2.811
R-HSA-72613	Eukaryotic Translation Initiation	1.544295e-03	2.811
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	1.844937e-03	2.734
R-HSA-69618	Mitotic Spindle Checkpoint	2.088865e-03	2.680
R-HSA-977225	Amyloid fiber formation	2.092819e-03	2.679
R-HSA-2467813	Separation of Sister Chromatids	2.122679e-03	2.673
R-HSA-453274	Mitotic G2-G2/M phases	2.149027e-03	2.668
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	2.150968e-03	2.667
R-HSA-73857	RNA Polymerase II Transcription	2.236405e-03	2.650
R-HSA-390522	Striated Muscle Contraction	2.325799e-03	2.633
R-HSA-73894	DNA Repair	2.370928e-03	2.625
R-HSA-927802	Nonsense-Mediated Decay (NMD)	2.379773e-03	2.623
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	2.379773e-03	2.623
R-HSA-376176	Signaling by ROBO receptors	2.465168e-03	2.608
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	2.768392e-03	2.558
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	2.898879e-03	2.538
R-HSA-445095	Interaction between L1 and Ankyrins	3.114315e-03	2.507
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	3.310646e-03	2.480
R-HSA-141424	Amplification of signal from the kinetochores	3.310646e-03	2.480
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri...	3.248545e-03	2.488
R-HSA-69206	G1/S Transition	3.262724e-03	2.486
R-HSA-5620922	BBSome-mediated cargo-targeting to cilium	3.348367e-03	2.475
R-HSA-72312	rRNA processing	3.093311e-03	2.510
R-HSA-9610379	HCMV Late Events	2.968126e-03	2.528
R-HSA-72764	Eukaryotic Translation Termination	3.526674e-03	2.453
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	3.541058e-03	2.451
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	3.586607e-03	2.445
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	3.612474e-03	2.442
R-HSA-69242	S Phase	3.660462e-03	2.436
R-HSA-9909648	Regulation of PD-L1(CD274) expression	3.675109e-03	2.435
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	3.815929e-03	2.418
R-HSA-69239	Synthesis of DNA	3.951792e-03	2.403
R-HSA-9948299	Ribosome-associated quality control	3.972909e-03	2.401
R-HSA-156902	Peptide chain elongation	4.283069e-03	2.368
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	4.363161e-03	2.360
R-HSA-9764561	Regulation of CDH1 Function	4.592816e-03	2.338
R-HSA-168255	Influenza Infection	5.455917e-03	2.263
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	5.473761e-03	2.262
R-HSA-168273	Influenza Viral RNA Transcription and Replication	5.602634e-03	2.252
R-HSA-399719	Trafficking of AMPA receptors	5.732127e-03	2.242
R-HSA-8856828	Clathrin-mediated endocytosis	5.790272e-03	2.237
R-HSA-9675126	Diseases of mitotic cell cycle	6.587607e-03	2.181
R-HSA-69052	Switching of origins to a post-replicative state	7.473277e-03	2.126
R-HSA-69190	DNA strand elongation	6.587607e-03	2.181
R-HSA-5633007	Regulation of TP53 Activity	7.452192e-03	2.128
R-HSA-399721	Glutamate binding, activation of AMPA receptors and synaptic plasticity	7.534520e-03	2.123
R-HSA-212436	Generic Transcription Pathway	7.559482e-03	2.122
R-HSA-9824446	Viral Infection Pathways	7.722620e-03	2.112
R-HSA-6802957	Oncogenic MAPK signaling	7.849543e-03	2.105
R-HSA-69275	G2/M Transition	7.894666e-03	2.103
R-HSA-5696398	Nucleotide Excision Repair	8.068476e-03	2.093
R-HSA-68949	Orc1 removal from chromatin	8.138940e-03	2.089
R-HSA-674695	RNA Polymerase II Pre-transcription Events	8.140209e-03	2.089
R-HSA-3700989	Transcriptional Regulation by TP53	8.688364e-03	2.061
R-HSA-162906	HIV Infection	8.744387e-03	2.058
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	9.250682e-03	2.034
R-HSA-195721	Signaling by WNT	9.682637e-03	2.014
R-HSA-5696400	Dual Incision in GG-NER	9.724761e-03	2.012
R-HSA-390466	Chaperonin-mediated protein folding	9.896274e-03	2.005
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	1.047084e-02	1.980
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	1.056522e-02	1.976
R-HSA-3928662	EPHB-mediated forward signaling	1.062897e-02	1.974
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	1.062897e-02	1.974
R-HSA-9665348	Signaling by ERBB2 ECD mutants	1.068527e-02	1.971
R-HSA-9613829	Chaperone Mediated Autophagy	1.068527e-02	1.971
R-HSA-8854518	AURKA Activation by TPX2	1.079345e-02	1.967
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	1.167597e-02	1.933
R-HSA-9659379	Sensory processing of sound	1.219361e-02	1.914
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	1.371341e-02	1.863
R-HSA-69091	Polymerase switching	1.371341e-02	1.863
R-HSA-69109	Leading Strand Synthesis	1.371341e-02	1.863
R-HSA-3000484	Scavenging by Class F Receptors	1.371341e-02	1.863
R-HSA-69205	G1/S-Specific Transcription	1.234668e-02	1.908
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig...	1.277774e-02	1.894
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	1.262725e-02	1.899
R-HSA-9629569	Protein hydroxylation	1.480809e-02	1.830
R-HSA-2408557	Selenocysteine synthesis	1.310186e-02	1.883
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	1.277774e-02	1.894
R-HSA-192823	Viral mRNA Translation	1.492634e-02	1.826
R-HSA-391251	Protein folding	1.520851e-02	1.818
R-HSA-389948	Co-inhibition by PD-1	1.541409e-02	1.812
R-HSA-9659787	Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects	1.673064e-02	1.776
R-HSA-9661069	Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	1.673064e-02	1.776
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	1.673064e-02	1.776
R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription	1.722036e-02	1.764
R-HSA-9766229	Degradation of CDH1	1.743555e-02	1.759
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	1.788134e-02	1.748
R-HSA-68962	Activation of the pre-replicative complex	1.788134e-02	1.748
R-HSA-72172	mRNA Splicing	1.917370e-02	1.717
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	1.987946e-02	1.702
R-HSA-9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	1.987946e-02	1.702
R-HSA-9933939	Formation of the polybromo-BAF (pBAF) complex	2.013263e-02	1.696
R-HSA-9013694	Signaling by NOTCH4	2.038250e-02	1.691
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	2.123439e-02	1.673
R-HSA-72163	mRNA Splicing - Major Pathway	2.155467e-02	1.666
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	2.173207e-02	1.663
R-HSA-380259	Loss of Nlp from mitotic centrosomes	2.173207e-02	1.663
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in ...	2.279399e-02	1.642
R-HSA-936837	Ion transport by P-type ATPases	2.348750e-02	1.629
R-HSA-110312	Translesion synthesis by REV1	2.393102e-02	1.621
R-HSA-446353	Cell-extracellular matrix interactions	2.393102e-02	1.621
R-HSA-162587	HIV Life Cycle	2.448599e-02	1.611
R-HSA-432722	Golgi Associated Vesicle Biogenesis	2.478687e-02	1.606
R-HSA-73762	RNA Polymerase I Transcription Initiation	2.551970e-02	1.593
R-HSA-5696394	DNA Damage Recognition in GG-NER	2.797820e-02	1.553
R-HSA-5656121	Translesion synthesis by POLI	2.813496e-02	1.551
R-HSA-162909	Host Interactions of HIV factors	2.844623e-02	1.546
R-HSA-9944971	Loss of Function of KMT2D in Kabuki Syndrome	3.324812e-02	1.478
R-HSA-9944997	Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	3.324812e-02	1.478
R-HSA-5655862	Translesion synthesis by POLK	3.275114e-02	1.485
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	3.506401e-02	1.455
R-HSA-180746	Nuclear import of Rev protein	3.098873e-02	1.509
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	3.627078e-02	1.440
R-HSA-9649948	Signaling downstream of RAS mutants	3.627078e-02	1.440
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	3.627078e-02	1.440
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	3.098873e-02	1.509
R-HSA-6802949	Signaling by RAS mutants	3.627078e-02	1.440
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	3.165208e-02	1.500
R-HSA-114608	Platelet degranulation	3.478281e-02	1.459
R-HSA-176974	Unwinding of DNA	3.165208e-02	1.500
R-HSA-2980766	Nuclear Envelope Breakdown	3.407028e-02	1.468
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	3.165208e-02	1.500
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	3.407028e-02	1.468
R-HSA-9833482	PKR-mediated signaling	3.085548e-02	1.511
R-HSA-2408522	Selenoamino acid metabolism	3.352014e-02	1.475
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	3.714545e-02	1.430
R-HSA-6798695	Neutrophil degranulation	3.771598e-02	1.423
R-HSA-2028269	Signaling by Hippo	3.778391e-02	1.423
R-HSA-111458	Formation of apoptosome	3.863477e-02	1.413
R-HSA-9627069	Regulation of the apoptosome activity	3.863477e-02	1.413
R-HSA-9762292	Regulation of CDH11 function	3.863477e-02	1.413
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	3.863477e-02	1.413
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	3.965658e-02	1.402
R-HSA-8939211	ESR-mediated signaling	3.970033e-02	1.401
R-HSA-72766	Translation	4.003761e-02	1.398
R-HSA-9609690	HCMV Early Events	4.104625e-02	1.387
R-HSA-199992	trans-Golgi Network Vesicle Budding	4.129362e-02	1.384
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	4.183915e-02	1.378
R-HSA-9700206	Signaling by ALK in cancer	4.183915e-02	1.378
R-HSA-1227986	Signaling by ERBB2	4.241159e-02	1.373
R-HSA-162599	Late Phase of HIV Life Cycle	4.267436e-02	1.370
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	4.323532e-02	1.364
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	4.323532e-02	1.364
R-HSA-4419969	Depolymerization of the Nuclear Lamina	4.323532e-02	1.364
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	4.402299e-02	1.356
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	4.402299e-02	1.356
R-HSA-5576892	Phase 0 - rapid depolarisation	4.600724e-02	1.337
R-HSA-388841	Regulation of T cell activation by CD28 family	4.612500e-02	1.336
R-HSA-9013957	TLR3-mediated TICAM1-dependent programmed cell death	4.615262e-02	1.336
R-HSA-5660489	MTF1 activates gene expression	4.615262e-02	1.336
R-HSA-9711097	Cellular response to starvation	4.669102e-02	1.331
R-HSA-380287	Centrosome maturation	4.983793e-02	1.302
R-HSA-3000171	Non-integrin membrane-ECM interactions	4.983793e-02	1.302
R-HSA-9664565	Signaling by ERBB2 KD Mutants	5.087028e-02	1.294
R-HSA-9709570	Impaired BRCA2 binding to RAD51	5.087028e-02	1.294
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	5.290142e-02	1.277
R-HSA-177243	Interactions of Rev with host cellular proteins	5.345115e-02	1.272
R-HSA-111461	Cytochrome c-mediated apoptotic response	5.472362e-02	1.262
R-HSA-70171	Glycolysis	5.497656e-02	1.260
R-HSA-9661070	Defective translocation of RB1 mutants to the nucleus	5.506314e-02	1.259
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	5.506314e-02	1.259
R-HSA-9823730	Formation of definitive endoderm	5.539166e-02	1.257
R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex	5.539166e-02	1.257
R-HSA-1227990	Signaling by ERBB2 in Cancer	5.602289e-02	1.252
R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	6.056705e-02	1.218
R-HSA-68911	G2 Phase	6.056705e-02	1.218
R-HSA-9833576	CDH11 homotypic and heterotypic interactions	7.628638e-02	1.118
R-HSA-111459	Activation of caspases through apoptosome-mediated cleavage	7.628638e-02	1.118
R-HSA-68689	CDC6 association with the ORC:origin complex	7.628638e-02	1.118
R-HSA-438066	Unblocking of NMDA receptors, glutamate binding and activation	6.919558e-02	1.160
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	6.919558e-02	1.160
R-HSA-72187	mRNA 3'-end processing	5.737188e-02	1.241
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	5.737188e-02	1.241
R-HSA-112382	Formation of RNA Pol II elongation complex	5.737188e-02	1.241
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	6.149619e-02	1.211
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th...	6.149619e-02	1.211
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	6.579717e-02	1.182
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	7.027527e-02	1.153
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	7.493061e-02	1.125
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	7.493061e-02	1.125
R-HSA-69186	Lagging Strand Synthesis	6.209037e-02	1.207
R-HSA-167172	Transcription of the HIV genome	7.087832e-02	1.149
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	7.628638e-02	1.118
R-HSA-9930044	Nuclear RNA decay	7.321276e-02	1.135
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno...	7.321276e-02	1.135
R-HSA-75955	RNA Polymerase II Transcription Elongation	6.149619e-02	1.211
R-HSA-9913351	Formation of the dystrophin-glycoprotein complex (DGC)	6.146498e-02	1.211
R-HSA-9656223	Signaling by RAF1 mutants	6.267304e-02	1.203
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	7.349104e-02	1.134
R-HSA-8876384	Listeria monocytogenes entry into host cells	6.919558e-02	1.160
R-HSA-379716	Cytosolic tRNA aminoacylation	6.761430e-02	1.170
R-HSA-73933	Resolution of Abasic Sites (AP sites)	5.795207e-02	1.237
R-HSA-3214841	PKMTs methylate histone lysines	5.795207e-02	1.237
R-HSA-445355	Smooth Muscle Contraction	6.149619e-02	1.211
R-HSA-5578775	Ion homeostasis	7.493061e-02	1.125
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	5.947175e-02	1.226
R-HSA-111464	SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes	6.056705e-02	1.218
R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	7.628638e-02	1.118
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	7.321276e-02	1.135
R-HSA-111463	SMAC (DIABLO) binds to IAPs	6.056705e-02	1.218
R-HSA-111469	SMAC, XIAP-regulated apoptotic response	7.628638e-02	1.118
R-HSA-9764302	Regulation of CDH19 Expression and Function	7.628638e-02	1.118
R-HSA-69601	Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	8.375449e-02	1.077
R-HSA-69613	p53-Independent G1/S DNA Damage Checkpoint	8.375449e-02	1.077
R-HSA-1489509	DAG and IP3 signaling	8.375449e-02	1.077
R-HSA-9933937	Formation of the canonical BAF (cBAF) complex	8.380837e-02	1.077
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	8.397221e-02	1.076
R-HSA-453276	Regulation of mitotic cell cycle	8.397221e-02	1.076
R-HSA-5620920	Cargo trafficking to the periciliary membrane	8.397221e-02	1.076
R-HSA-3000170	Syndecan interactions	8.459400e-02	1.073
R-HSA-6782135	Dual incision in TC-NER	8.477189e-02	1.072
R-HSA-9701190	Defective homologous recombination repair (HRR) due to BRCA2 loss of function	8.609537e-02	1.065
R-HSA-9675136	Diseases of DNA Double-Strand Break Repair	8.609537e-02	1.065
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	8.956913e-02	1.048
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	8.956913e-02	1.048
R-HSA-8878159	Transcriptional regulation by RUNX3	9.147931e-02	1.039
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	9.286780e-02	1.032
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	9.286780e-02	1.032
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	9.295297e-02	1.032
R-HSA-2559585	Oncogene Induced Senescence	9.295297e-02	1.032
R-HSA-9842640	Signaling by LTK in cancer	9.312355e-02	1.031
R-HSA-449147	Signaling by Interleukins	9.375169e-02	1.028
R-HSA-9609646	HCMV Infection	9.393073e-02	1.027
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	9.470499e-02	1.024
R-HSA-399954	Sema3A PAK dependent Axon repulsion	9.470499e-02	1.024
R-HSA-8943724	Regulation of PTEN gene transcription	9.531568e-02	1.021
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	9.559776e-02	1.020
R-HSA-9670621	Defective Inhibition of DNA Recombination at Telomere	1.070975e-01	0.970
R-HSA-9673013	Diseases of Telomere Maintenance	1.070975e-01	0.970
R-HSA-9006821	Alternative Lengthening of Telomeres (ALT)	1.070975e-01	0.970
R-HSA-9709275	Impaired BRCA2 translocation to the nucleus	1.070975e-01	0.970
R-HSA-5602566	TICAM1 deficiency - HSE	1.070975e-01	0.970
R-HSA-9670615	Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	1.070975e-01	0.970
R-HSA-9763198	Impaired BRCA2 binding to SEM1 (DSS1)	1.070975e-01	0.970
R-HSA-9670613	Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	1.070975e-01	0.970
R-HSA-2562578	TRIF-mediated programmed cell death	1.109081e-01	0.955
R-HSA-114516	Disinhibition of SNARE formation	1.109081e-01	0.955
R-HSA-9828211	Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	1.294849e-01	0.888
R-HSA-196025	Formation of annular gap junctions	1.294849e-01	0.888
R-HSA-9613354	Lipophagy	1.487131e-01	0.828
R-HSA-190873	Gap junction degradation	1.487131e-01	0.828
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	1.061463e-01	0.974
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	1.180962e-01	0.928
R-HSA-5637812	Signaling by EGFRvIII in Cancer	1.305182e-01	0.884
R-HSA-5637810	Constitutive Signaling by EGFRvIII	1.305182e-01	0.884
R-HSA-9615710	Late endosomal microautophagy	1.394878e-01	0.855
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	1.074757e-01	0.969
R-HSA-180910	Vpr-mediated nuclear import of PICs	1.074757e-01	0.969
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	1.497607e-01	0.825
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	1.230339e-01	0.910
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	1.311836e-01	0.882
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	1.311836e-01	0.882
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	1.481844e-01	0.829
R-HSA-167161	HIV Transcription Initiation	1.481844e-01	0.829
R-HSA-75953	RNA Polymerase II Transcription Initiation	1.481844e-01	0.829
R-HSA-72649	Translation initiation complex formation	1.435145e-01	0.843
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	1.034927e-01	0.985
R-HSA-383280	Nuclear Receptor transcription pathway	1.196505e-01	0.922
R-HSA-156711	Polo-like kinase mediated events	1.433750e-01	0.844
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa...	1.395699e-01	0.855
R-HSA-5656169	Termination of translesion DNA synthesis	1.394878e-01	0.855
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	1.142789e-01	0.942
R-HSA-174411	Polymerase switching on the C-strand of the telomere	1.015096e-01	0.993
R-HSA-8853659	RET signaling	1.000816e-01	1.000
R-HSA-1250196	SHC1 events in ERBB2 signaling	1.497607e-01	0.825
R-HSA-9932451	SWI/SNF chromatin remodelers	1.015096e-01	0.993
R-HSA-9932444	ATP-dependent chromatin remodelers	1.015096e-01	0.993
R-HSA-5696395	Formation of Incision Complex in GG-NER	1.311836e-01	0.882
R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression	1.294849e-01	0.888
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	1.481844e-01	0.829
R-HSA-9620244	Long-term potentiation	1.015096e-01	0.993
R-HSA-5685942	HDR through Homologous Recombination (HRR)	1.375618e-01	0.862
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	1.151287e-01	0.939
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anapha...	1.180962e-01	0.928
R-HSA-5689603	UCH proteinases	1.087362e-01	0.964
R-HSA-450341	Activation of the AP-1 family of transcription factors	1.487131e-01	0.828
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	1.229712e-01	0.910
R-HSA-8863795	Downregulation of ERBB2 signaling	1.497607e-01	0.825
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	1.329397e-01	0.876
R-HSA-5617833	Cilium Assembly	1.425770e-01	0.846
R-HSA-111471	Apoptotic factor-mediated response	1.433750e-01	0.844
R-HSA-69541	Stabilization of p53	1.230339e-01	0.910
R-HSA-199991	Membrane Trafficking	1.056179e-01	0.976
R-HSA-77042	Formation of editosomes by ADAR proteins	1.070975e-01	0.970
R-HSA-373756	SDK interactions	1.070975e-01	0.970
R-HSA-176033	Interactions of Vpr with host cellular proteins	1.311836e-01	0.882
R-HSA-1169091	Activation of NF-kappaB in B cells	1.217926e-01	0.914
R-HSA-73856	RNA Polymerase II Transcription Termination	1.008480e-01	0.996
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	1.065517e-01	0.972
R-HSA-1852241	Organelle biogenesis and maintenance	1.160627e-01	0.935
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	1.065517e-01	0.972
R-HSA-6784531	tRNA processing in the nucleus	1.065517e-01	0.972
R-HSA-9793380	Formation of paraxial mesoderm	1.008480e-01	0.996
R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	1.018377e-01	0.992
R-HSA-447041	CHL1 interactions	1.109081e-01	0.955
R-HSA-9020702	Interleukin-1 signaling	1.088195e-01	0.963
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	1.162973e-01	0.934
R-HSA-69615	G1/S DNA Damage Checkpoints	1.124249e-01	0.949
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	1.486715e-01	0.828
R-HSA-8941858	Regulation of RUNX3 expression and activity	1.311836e-01	0.882
R-HSA-9604323	Negative regulation of NOTCH4 signaling	1.311836e-01	0.882
R-HSA-373760	L1CAM interactions	1.253658e-01	0.902
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	1.151287e-01	0.939
R-HSA-8939246	RUNX1 regulates transcription of genes involved in differentiation of myeloid ce...	1.294849e-01	0.888
R-HSA-983712	Ion channel transport	1.386799e-01	0.858
R-HSA-70326	Glucose metabolism	1.300429e-01	0.886
R-HSA-9818032	NFE2L2 regulating MDR associated enzymes	1.487131e-01	0.828
R-HSA-70263	Gluconeogenesis	1.018377e-01	0.992
R-HSA-430116	GP1b-IX-V activation signalling	1.487131e-01	0.828
R-HSA-111933	Calmodulin induced events	1.000816e-01	1.000
R-HSA-111997	CaM pathway	1.000816e-01	1.000
R-HSA-5336415	Uptake and function of diphtheria toxin	1.109081e-01	0.955
R-HSA-9825895	Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ...	1.294849e-01	0.888
R-HSA-9834752	Respiratory syncytial virus genome replication	1.487131e-01	0.828
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	1.481844e-01	0.829
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptor...	1.180962e-01	0.928
R-HSA-9679504	Translation of Replicase and Assembly of the Replication Transcription Complex	1.433750e-01	0.844
R-HSA-975155	MyD88 dependent cascade initiated on endosome	1.541178e-01	0.812
R-HSA-176034	Interactions of Tat with host cellular proteins	1.562694e-01	0.806
R-HSA-9630794	Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4...	1.562694e-01	0.806
R-HSA-5083628	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	1.562694e-01	0.806
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	1.562694e-01	0.806
R-HSA-9632700	Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding...	1.562694e-01	0.806
R-HSA-3304347	Loss of Function of SMAD4 in Cancer	1.562694e-01	0.806
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	1.562694e-01	0.806
R-HSA-5602571	TRAF3 deficiency - HSE	1.562694e-01	0.806
R-HSA-5609974	Defective PGM1 causes PGM1-CDG	1.562694e-01	0.806
R-HSA-5678420	Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	1.562694e-01	0.806
R-HSA-9632693	Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects	1.562694e-01	0.806
R-HSA-9636667	Manipulation of host energy metabolism	1.562694e-01	0.806
R-HSA-9630750	Evasion of Oncogene Induced Senescence Due to p16INK4A Defects	1.562694e-01	0.806
R-HSA-352238	Breakdown of the nuclear lamina	1.562694e-01	0.806
R-HSA-9709603	Impaired BRCA2 binding to PALB2	1.566292e-01	0.805
R-HSA-110320	Translesion Synthesis by POLH	1.566292e-01	0.805
R-HSA-113510	E2F mediated regulation of DNA replication	1.566292e-01	0.805
R-HSA-111996	Ca-dependent events	1.570182e-01	0.804
R-HSA-195253	Degradation of beta-catenin by the destruction complex	1.580557e-01	0.801
R-HSA-69202	Cyclin E associated events during G1/S transition	1.580557e-01	0.801
R-HSA-6807878	COPI-mediated anterograde transport	1.583363e-01	0.800
R-HSA-72702	Ribosomal scanning and start codon recognition	1.589126e-01	0.799
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.589126e-01	0.799
R-HSA-166166	MyD88-independent TLR4 cascade	1.596626e-01	0.797
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	1.596626e-01	0.797
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	1.603129e-01	0.795
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	1.603129e-01	0.795
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	1.603129e-01	0.795
R-HSA-5083633	Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	2.027363e-01	0.693
R-HSA-1296067	Potassium transport channels	2.027363e-01	0.693
R-HSA-5083629	Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	2.027363e-01	0.693
R-HSA-9734735	Defective ADA disrupts (deoxy)adenosine deamination	2.027363e-01	0.693
R-HSA-5603037	IRAK4 deficiency (TLR5)	2.466467e-01	0.608
R-HSA-8952158	RUNX3 regulates BCL2L11 (BIM) transcription	2.881413e-01	0.540
R-HSA-1296025	ATP sensitive Potassium channels	2.881413e-01	0.540
R-HSA-1251932	PLCG1 events in ERBB2 signaling	2.881413e-01	0.540
R-HSA-3656532	TGFBR1 KD Mutants in Cancer	2.881413e-01	0.540
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ...	2.881413e-01	0.540
R-HSA-1306955	GRB7 events in ERBB2 signaling	2.881413e-01	0.540
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	1.684647e-01	0.773
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	1.886241e-01	0.724
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	1.886241e-01	0.724
R-HSA-203754	NOSIP mediated eNOS trafficking	3.273526e-01	0.485
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	3.273526e-01	0.485
R-HSA-9824878	Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	2.090865e-01	0.680
R-HSA-5339716	Signaling by GSK3beta mutants	2.090865e-01	0.680
R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	2.297577e-01	0.639
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	2.297577e-01	0.639
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	2.297577e-01	0.639
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	2.297577e-01	0.639
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	2.297577e-01	0.639
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	1.702436e-01	0.769
R-HSA-9701193	Defective homologous recombination repair (HRR) due to PALB2 loss of function	1.702436e-01	0.769
R-HSA-9704331	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	1.702436e-01	0.769
R-HSA-9704646	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of...	1.702436e-01	0.769
R-HSA-9701192	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	1.702436e-01	0.769
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	2.505527e-01	0.601
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	1.841814e-01	0.735
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	1.841814e-01	0.735
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	1.841814e-01	0.735
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ...	1.841814e-01	0.735
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	2.922172e-01	0.534
R-HSA-196299	Beta-catenin phosphorylation cascade	2.922172e-01	0.534
R-HSA-1855170	IPs transport between nucleus and cytosol	1.821875e-01	0.739
R-HSA-159227	Transport of the SLBP independent Mature mRNA	1.821875e-01	0.739
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	1.934755e-01	0.713
R-HSA-140534	Caspase activation via Death Receptors in the presence of ligand	3.129576e-01	0.505
R-HSA-176412	Phosphorylation of the APC/C	3.129576e-01	0.505
R-HSA-73776	RNA Polymerase II Promoter Escape	1.660621e-01	0.780
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD...	2.574842e-01	0.589
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	2.166655e-01	0.664
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	1.847415e-01	0.733
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	2.041433e-01	0.690
R-HSA-167287	HIV elongation arrest and recovery	3.031748e-01	0.518
R-HSA-167290	Pausing and recovery of HIV elongation	3.031748e-01	0.518
R-HSA-9927432	Developmental Lineage of Mammary Gland Myoepithelial Cells	3.185111e-01	0.497
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	2.774100e-01	0.557
R-HSA-1643713	Signaling by EGFR in Cancer	2.726336e-01	0.564
R-HSA-9844594	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	2.774100e-01	0.557
R-HSA-9843743	Transcriptional regulation of brown and beige adipocyte differentiation	2.774100e-01	0.557
R-HSA-73893	DNA Damage Bypass	2.241847e-01	0.649
R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	2.090865e-01	0.680
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	2.405576e-01	0.619
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	1.984065e-01	0.702
R-HSA-191650	Regulation of gap junction activity	2.881413e-01	0.540
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	2.297577e-01	0.639
R-HSA-9796292	Formation of axial mesoderm	2.505527e-01	0.601
R-HSA-73863	RNA Polymerase I Transcription Termination	2.878733e-01	0.541
R-HSA-8941856	RUNX3 regulates NOTCH signaling	2.297577e-01	0.639
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	3.273526e-01	0.485
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	2.090865e-01	0.680
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	1.821875e-01	0.739
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	2.405576e-01	0.619
R-HSA-5674135	MAP2K and MAPK activation	3.024593e-01	0.519
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	2.726336e-01	0.564
R-HSA-9703465	Signaling by FLT3 fusion proteins	2.726336e-01	0.564
R-HSA-8939247	RUNX1 regulates transcription of genes involved in interleukin signaling	3.273526e-01	0.485
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	2.713952e-01	0.566
R-HSA-9865881	Complex III assembly	2.424551e-01	0.615
R-HSA-5673000	RAF activation	2.049740e-01	0.688
R-HSA-437239	Recycling pathway of L1	2.041433e-01	0.690
R-HSA-1236974	ER-Phagosome pathway	3.216623e-01	0.493
R-HSA-5218920	VEGFR2 mediated vascular permeability	2.898974e-01	0.538
R-HSA-9612973	Autophagy	2.861087e-01	0.543
R-HSA-75064	mRNA Editing: A to I Conversion	2.027363e-01	0.693
R-HSA-75102	C6 deamination of adenosine	2.027363e-01	0.693
R-HSA-5683177	Defective ABCC8 can cause hypo- and hyper-glycemias	2.027363e-01	0.693
R-HSA-9705677	SARS-CoV-2 targets PDZ proteins in cell-cell junction	2.881413e-01	0.540
R-HSA-9754119	Drug-mediated inhibition of CDK4/CDK6 activity	2.881413e-01	0.540
R-HSA-8866376	Reelin signalling pathway	3.273526e-01	0.485
R-HSA-8939245	RUNX1 regulates transcription of genes involved in BCR signaling	3.273526e-01	0.485
R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	3.273526e-01	0.485
R-HSA-9933947	Formation of the non-canonical BAF (ncBAF) complex	2.505527e-01	0.601
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	2.922172e-01	0.534
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	2.726336e-01	0.564
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	2.878733e-01	0.541
R-HSA-180786	Extension of Telomeres	1.832716e-01	0.737
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	2.350618e-01	0.629
R-HSA-5655302	Signaling by FGFR1 in disease	3.024593e-01	0.519
R-HSA-5653656	Vesicle-mediated transport	2.918935e-01	0.535
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	3.118998e-01	0.506
R-HSA-1839124	FGFR1 mutant receptor activation	1.821875e-01	0.739
R-HSA-1632852	Macroautophagy	2.872965e-01	0.542
R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands	2.713952e-01	0.566
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	3.030328e-01	0.519
R-HSA-111448	Activation of NOXA and translocation to mitochondria	2.881413e-01	0.540
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	1.934755e-01	0.713
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	1.943572e-01	0.711
R-HSA-975871	MyD88 cascade initiated on plasma membrane	1.704815e-01	0.768
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	1.704815e-01	0.768
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	1.704815e-01	0.768
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	1.768714e-01	0.752
R-HSA-1362300	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL...	3.129576e-01	0.505
R-HSA-450294	MAP kinase activation	2.002788e-01	0.698
R-HSA-6790901	rRNA modification in the nucleus and cytosol	2.178378e-01	0.662
R-HSA-69563	p53-Dependent G1 DNA Damage Response	2.241847e-01	0.649
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	2.241847e-01	0.649
R-HSA-448424	Interleukin-17 signaling	2.828154e-01	0.548
R-HSA-9675132	Diseases of cellular response to stress	2.027363e-01	0.693
R-HSA-9630747	Diseases of Cellular Senescence	2.027363e-01	0.693
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	2.505527e-01	0.601
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	1.711275e-01	0.767
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	2.922172e-01	0.534
R-HSA-5218921	VEGFR2 mediated cell proliferation	2.574842e-01	0.589
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	2.166655e-01	0.664
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	2.166655e-01	0.664
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	1.749919e-01	0.757
R-HSA-9932298	Degradation of CRY and PER proteins	3.024593e-01	0.519
R-HSA-5610780	Degradation of GLI1 by the proteasome	3.024593e-01	0.519
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	2.828154e-01	0.548
R-HSA-438064	Post NMDA receptor activation events	3.038314e-01	0.517
R-HSA-1266738	Developmental Biology	2.068558e-01	0.684
R-HSA-3214858	RMTs methylate histone arginines	1.753065e-01	0.756
R-HSA-109606	Intrinsic Pathway for Apoptosis	2.981409e-01	0.526
R-HSA-9824272	Somitogenesis	1.847415e-01	0.733
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	2.433770e-01	0.614
R-HSA-1592230	Mitochondrial biogenesis	3.266483e-01	0.486
R-HSA-5576891	Cardiac conduction	2.168496e-01	0.664
R-HSA-1538133	G0 and Early G1	1.711275e-01	0.767
R-HSA-9733709	Cardiogenesis	1.821875e-01	0.739
R-HSA-5607764	CLEC7A (Dectin-1) signaling	2.638829e-01	0.579
R-HSA-9856872	Malate-aspartate shuttle	2.713952e-01	0.566
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	1.821875e-01	0.739
R-HSA-442742	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	1.821875e-01	0.739
R-HSA-4641258	Degradation of DVL	2.405576e-01	0.619
R-HSA-9759475	Regulation of CDH11 Expression and Function	3.185111e-01	0.497
R-HSA-8863678	Neurodegenerative Diseases	2.424551e-01	0.615
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis...	2.424551e-01	0.615
R-HSA-8953750	Transcriptional Regulation by E2F6	2.650132e-01	0.577
R-HSA-202403	TCR signaling	2.586558e-01	0.587
R-HSA-379724	tRNA Aminoacylation	1.917028e-01	0.717
R-HSA-75108	Activation, myristolyation of BID and translocation to mitochondria	2.027363e-01	0.693
R-HSA-9820962	Assembly and release of respiratory syncytial virus (RSV) virions	1.684647e-01	0.773
R-HSA-420597	Nectin/Necl trans heterodimerization	3.273526e-01	0.485
R-HSA-447038	NrCAM interactions	3.273526e-01	0.485
R-HSA-9029558	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	2.505527e-01	0.601
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	2.922172e-01	0.534
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic...	3.129576e-01	0.505
R-HSA-180585	Vif-mediated degradation of APOBEC3G	2.285325e-01	0.641
R-HSA-4641257	Degradation of AXIN	2.405576e-01	0.619
R-HSA-9762114	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	2.405576e-01	0.619
R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	2.878733e-01	0.541
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	3.185111e-01	0.497
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	2.898974e-01	0.538
R-HSA-8948751	Regulation of PTEN stability and activity	2.658472e-01	0.575
R-HSA-418597	G alpha (z) signalling events	2.872978e-01	0.542
R-HSA-162582	Signal Transduction	2.527894e-01	0.597
R-HSA-198323	AKT phosphorylates targets in the cytosol	2.297577e-01	0.639
R-HSA-9012852	Signaling by NOTCH3	2.872978e-01	0.542
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	1.724457e-01	0.763
R-HSA-9675135	Diseases of DNA repair	1.943572e-01	0.711
R-HSA-8874177	ATF6B (ATF6-beta) activates chaperones	2.027363e-01	0.693
R-HSA-75157	FasL/ CD95L signaling	2.466467e-01	0.608
R-HSA-171007	p38MAPK events	2.922172e-01	0.534
R-HSA-180534	Vpu mediated degradation of CD4	1.934755e-01	0.713
R-HSA-5099900	WNT5A-dependent internalization of FZD4	3.129576e-01	0.505
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	2.049740e-01	0.688
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	2.049740e-01	0.688
R-HSA-169911	Regulation of Apoptosis	2.166655e-01	0.664
R-HSA-5610783	Degradation of GLI2 by the proteasome	3.024593e-01	0.519
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	3.024593e-01	0.519
R-HSA-9006925	Intracellular signaling by second messengers	3.175163e-01	0.498
R-HSA-5218859	Regulated Necrosis	2.637766e-01	0.579
R-HSA-6807070	PTEN Regulation	1.803085e-01	0.744
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	2.275773e-01	0.643
R-HSA-168276	NS1 Mediated Effects on Host Pathways	2.650132e-01	0.577
R-HSA-5362768	Hh mutants are degraded by ERAD	2.898974e-01	0.538
R-HSA-9929491	SPOP-mediated proteasomal degradation of PD-L1(CD274)	2.898974e-01	0.538
R-HSA-9679191	Potential therapeutics for SARS	2.487498e-01	0.604
R-HSA-163765	ChREBP activates metabolic gene expression	1.886241e-01	0.724
R-HSA-3299685	Detoxification of Reactive Oxygen Species	2.981409e-01	0.526
R-HSA-9022692	Regulation of MECP2 expression and activity	1.821875e-01	0.739
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	2.650132e-01	0.577
R-HSA-9929356	GSK3B-mediated proteasomal degradation of PD-L1(CD274)	2.650132e-01	0.577
R-HSA-9856649	Transcriptional and post-translational regulation of MITF-M expression and activ...	1.651806e-01	0.782
R-HSA-8983711	OAS antiviral response	2.297577e-01	0.639
R-HSA-5620971	Pyroptosis	3.031748e-01	0.518
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	3.129576e-01	0.505
R-HSA-76002	Platelet activation, signaling and aggregation	2.341886e-01	0.630
R-HSA-1280215	Cytokine Signaling in Immune system	1.953606e-01	0.709
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	2.898974e-01	0.538
R-HSA-381119	Unfolded Protein Response (UPR)	2.739880e-01	0.562
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	2.222590e-01	0.653
R-HSA-9678108	SARS-CoV-1 Infection	3.092368e-01	0.510
R-HSA-168316	Assembly of Viral Components at the Budding Site	3.273526e-01	0.485
R-HSA-9694676	Translation of Replicase and Assembly of the Replication Transcription Complex	2.128833e-01	0.672
R-HSA-5387390	Hh mutants abrogate ligand secretion	3.277442e-01	0.484
R-HSA-202424	Downstream TCR signaling	3.306434e-01	0.481
R-HSA-191859	snRNP Assembly	3.310181e-01	0.480
R-HSA-194441	Metabolism of non-coding RNA	3.310181e-01	0.480
R-HSA-1169408	ISG15 antiviral mechanism	3.315550e-01	0.479
R-HSA-77595	Processing of Intronless Pre-mRNAs	3.335625e-01	0.477
R-HSA-936964	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	3.335625e-01	0.477
R-HSA-70370	Galactose catabolism	3.335625e-01	0.477
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	3.335625e-01	0.477
R-HSA-9675151	Disorders of Developmental Biology	3.335625e-01	0.477
R-HSA-5660526	Response to metal ions	3.335625e-01	0.477
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	3.338562e-01	0.476
R-HSA-199977	ER to Golgi Anterograde Transport	3.351809e-01	0.475
R-HSA-9006931	Signaling by Nuclear Receptors	3.364870e-01	0.473
R-HSA-69231	Cyclin D associated events in G1	3.404370e-01	0.468
R-HSA-69236	G1 Phase	3.404370e-01	0.468
R-HSA-9907900	Proteasome assembly	3.404370e-01	0.468
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	3.404370e-01	0.468
R-HSA-351202	Metabolism of polyamines	3.420596e-01	0.466
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	3.421546e-01	0.466
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	3.422339e-01	0.466
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	3.422339e-01	0.466
R-HSA-9730414	MITF-M-regulated melanocyte development	3.444133e-01	0.463
R-HSA-182971	EGFR downregulation	3.491858e-01	0.457
R-HSA-112043	PLC beta mediated events	3.531262e-01	0.452
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	3.531442e-01	0.452
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	3.531442e-01	0.452
R-HSA-4608870	Asymmetric localization of PCP proteins	3.531442e-01	0.452
R-HSA-5678895	Defective CFTR causes cystic fibrosis	3.531442e-01	0.452
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	3.531442e-01	0.452
R-HSA-1963642	PI3K events in ERBB2 signaling	3.539838e-01	0.451
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	3.539838e-01	0.451
R-HSA-9909505	Modulation of host responses by IFN-stimulated genes	3.539838e-01	0.451
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to cla...	3.539838e-01	0.451
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	3.539838e-01	0.451
R-HSA-9827857	Specification of primordial germ cells	3.539838e-01	0.451
R-HSA-9692914	SARS-CoV-1-host interactions	3.539910e-01	0.451
R-HSA-416482	G alpha (12/13) signalling events	3.612934e-01	0.442
R-HSA-4086400	PCP/CE pathway	3.612934e-01	0.442
R-HSA-1268020	Mitochondrial protein import	3.642083e-01	0.439
R-HSA-9017802	Noncanonical activation of NOTCH3	3.644064e-01	0.438
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	3.644064e-01	0.438
R-HSA-9652817	Signaling by MAPK mutants	3.644064e-01	0.438
R-HSA-5660668	CLEC7A/inflammasome pathway	3.644064e-01	0.438
R-HSA-8937144	Aryl hydrocarbon receptor signalling	3.644064e-01	0.438
R-HSA-195399	VEGF binds to VEGFR leading to receptor dimerization	3.644064e-01	0.438
R-HSA-194313	VEGF ligand-receptor interactions	3.644064e-01	0.438
R-HSA-111457	Release of apoptotic factors from the mitochondria	3.644064e-01	0.438
R-HSA-427652	Sodium-coupled phosphate cotransporters	3.644064e-01	0.438
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen...	3.644064e-01	0.438
R-HSA-75158	TRAIL signaling	3.644064e-01	0.438
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	3.644768e-01	0.438
R-HSA-1296065	Inwardly rectifying K+ channels	3.644768e-01	0.438
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	3.658155e-01	0.437
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	3.658155e-01	0.437
R-HSA-446652	Interleukin-1 family signaling	3.702838e-01	0.431
R-HSA-1236975	Antigen processing-Cross presentation	3.708430e-01	0.431
R-HSA-3928664	Ephrin signaling	3.741794e-01	0.427
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	3.741794e-01	0.427
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	3.741794e-01	0.427
R-HSA-9614657	FOXO-mediated transcription of cell death genes	3.741794e-01	0.427
R-HSA-9926550	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh...	3.741794e-01	0.427
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	3.758208e-01	0.425
R-HSA-9837999	Mitochondrial protein degradation	3.759901e-01	0.425
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	3.797076e-01	0.421
R-HSA-5675482	Regulation of necroptotic cell death	3.797076e-01	0.421
R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	3.797076e-01	0.421
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	3.863827e-01	0.413
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	3.941122e-01	0.404
R-HSA-9754189	Germ layer formation at gastrulation	3.941122e-01	0.404
R-HSA-844456	The NLRP3 inflammasome	3.941122e-01	0.404
R-HSA-5693537	Resolution of D-Loop Structures	3.948579e-01	0.404
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	3.948579e-01	0.404
R-HSA-114508	Effects of PIP2 hydrolysis	3.948579e-01	0.404
R-HSA-177539	Autointegration results in viral DNA circles	3.994211e-01	0.399
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation	3.994211e-01	0.399
R-HSA-8857538	PTK6 promotes HIF1A stabilization	3.994211e-01	0.399
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	3.994211e-01	0.399
R-HSA-351143	Agmatine biosynthesis	3.994211e-01	0.399
R-HSA-69478	G2/M DNA replication checkpoint	3.994211e-01	0.399
R-HSA-447043	Neurofascin interactions	3.994211e-01	0.399
R-HSA-175567	Integration of viral DNA into host genomic DNA	3.994211e-01	0.399
R-HSA-199920	CREB phosphorylation	3.994211e-01	0.399
R-HSA-157858	Gap junction trafficking and regulation	4.038461e-01	0.394
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	4.057581e-01	0.392
R-HSA-9735869	SARS-CoV-1 modulates host translation machinery	4.099089e-01	0.387
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	4.099089e-01	0.387
R-HSA-168638	NOD1/2 Signaling Pathway	4.099089e-01	0.387
R-HSA-168898	Toll-like Receptor Cascades	4.117673e-01	0.385
R-HSA-170834	Signaling by TGF-beta Receptor Complex	4.124852e-01	0.385
R-HSA-71288	Creatine metabolism	4.137499e-01	0.383
R-HSA-6807004	Negative regulation of MET activity	4.137499e-01	0.383
R-HSA-5658442	Regulation of RAS by GAPs	4.164271e-01	0.380
R-HSA-112040	G-protein mediated events	4.195390e-01	0.377
R-HSA-187687	Signalling to ERKs	4.248427e-01	0.372
R-HSA-5663205	Infectious disease	4.289134e-01	0.368
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	4.289471e-01	0.368
R-HSA-5358346	Hedgehog ligand biogenesis	4.289471e-01	0.368
R-HSA-8951430	RUNX3 regulates WNT signaling	4.325088e-01	0.364
R-HSA-428890	Role of ABL in ROBO-SLIT signaling	4.325088e-01	0.364
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	4.325088e-01	0.364
R-HSA-72731	Recycling of eIF2:GDP	4.325088e-01	0.364
R-HSA-2470946	Cohesin Loading onto Chromatin	4.325088e-01	0.364
R-HSA-8932506	DAG1 core M1 glycosylations	4.325088e-01	0.364
R-HSA-5576890	Phase 3 - rapid repolarisation	4.325088e-01	0.364
R-HSA-203641	NOSTRIN mediated eNOS trafficking	4.325088e-01	0.364
R-HSA-8851907	MET activates PI3K/AKT signaling	4.325088e-01	0.364
R-HSA-9603381	Activated NTRK3 signals through PI3K	4.325088e-01	0.364
R-HSA-139915	Activation of PUMA and translocation to mitochondria	4.325088e-01	0.364
R-HSA-426117	Cation-coupled Chloride cotransporters	4.325088e-01	0.364
R-HSA-9686347	Microbial modulation of RIPK1-mediated regulated necrosis	4.325088e-01	0.364
R-HSA-162594	Early Phase of HIV Life Cycle	4.330646e-01	0.363
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	4.330646e-01	0.363
R-HSA-9824594	Regulation of MITF-M-dependent genes involved in apoptosis	4.330646e-01	0.363
R-HSA-167044	Signalling to RAS	4.330646e-01	0.363
R-HSA-9819196	Zygotic genome activation (ZGA)	4.330646e-01	0.363
R-HSA-913531	Interferon Signaling	4.348326e-01	0.362
R-HSA-6804757	Regulation of TP53 Degradation	4.396432e-01	0.357
R-HSA-432720	Lysosome Vesicle Biogenesis	4.396432e-01	0.357
R-HSA-9682385	FLT3 signaling in disease	4.396432e-01	0.357
R-HSA-9931269	AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	4.413953e-01	0.355
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	4.506665e-01	0.346
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	4.520323e-01	0.345
R-HSA-2995383	Initiation of Nuclear Envelope (NE) Reformation	4.520323e-01	0.345
R-HSA-8949215	Mitochondrial calcium ion transport	4.520323e-01	0.345
R-HSA-5689896	Ovarian tumor domain proteases	4.542952e-01	0.343
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	4.578626e-01	0.339
R-HSA-5632684	Hedgehog 'on' state	4.632138e-01	0.334
R-HSA-446107	Type I hemidesmosome assembly	4.637755e-01	0.334
R-HSA-3371378	Regulation by c-FLIP	4.637755e-01	0.334
R-HSA-8932504	DAG1 core M2 glycosylations	4.637755e-01	0.334
R-HSA-69416	Dimerization of procaspase-8	4.637755e-01	0.334
R-HSA-9028335	Activated NTRK2 signals through PI3K	4.637755e-01	0.334
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	4.637755e-01	0.334
R-HSA-193634	Axonal growth inhibition (RHOA activation)	4.637755e-01	0.334
R-HSA-5652227	Fructose biosynthesis	4.637755e-01	0.334
R-HSA-9927354	Co-stimulation by ICOS	4.637755e-01	0.334
R-HSA-9010642	ROBO receptors bind AKAP5	4.637755e-01	0.334
R-HSA-9734207	Nucleotide salvage defects	4.637755e-01	0.334
R-HSA-442729	CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	4.637755e-01	0.334
R-HSA-202131	Metabolism of nitric oxide: NOS3 activation and regulation	4.687848e-01	0.329
R-HSA-5213460	RIPK1-mediated regulated necrosis	4.687848e-01	0.329
R-HSA-9958790	SLC-mediated transport of inorganic anions	4.687848e-01	0.329
R-HSA-9663891	Selective autophagy	4.702456e-01	0.328
R-HSA-350054	Notch-HLH transcription pathway	4.706325e-01	0.327
R-HSA-9938206	Developmental Lineage of Mammary Stem Cells	4.706325e-01	0.327
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	4.706325e-01	0.327
R-HSA-166208	mTORC1-mediated signalling	4.706325e-01	0.327
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	4.706325e-01	0.327
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specif...	4.706325e-01	0.327
R-HSA-9758941	Gastrulation	4.730335e-01	0.325
R-HSA-9856651	MITF-M-dependent gene expression	4.804410e-01	0.318
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	4.830994e-01	0.316
R-HSA-6806003	Regulation of TP53 Expression and Degradation	4.830994e-01	0.316
R-HSA-9820965	Respiratory syncytial virus (RSV) genome replication, transcription and translat...	4.830994e-01	0.316
R-HSA-5673001	RAF/MAP kinase cascade	4.844987e-01	0.315
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	4.888484e-01	0.311
R-HSA-177929	Signaling by EGFR	4.902770e-01	0.310
R-HSA-193648	NRAGE signals death through JNK	4.902770e-01	0.310
R-HSA-170984	ARMS-mediated activation	4.933213e-01	0.307
R-HSA-5218900	CASP8 activity is inhibited	4.933213e-01	0.307
R-HSA-9700645	ALK mutants bind TKIs	4.933213e-01	0.307
R-HSA-2465910	MASTL Facilitates Mitotic Progression	4.933213e-01	0.307
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P...	4.933213e-01	0.307
R-HSA-9619229	Activation of RAC1 downstream of NMDARs	4.933213e-01	0.307
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	4.933213e-01	0.307
R-HSA-193697	p75NTR regulates axonogenesis	4.933213e-01	0.307
R-HSA-75072	mRNA Editing	4.933213e-01	0.307
R-HSA-418889	Caspase activation via Dependence Receptors in the absence of ligand	4.933213e-01	0.307
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	4.933213e-01	0.307
R-HSA-9768777	Regulation of NPAS4 gene transcription	4.933213e-01	0.307
R-HSA-9840373	Cellular response to mitochondrial stress	4.933213e-01	0.307
R-HSA-442380	Zinc influx into cells by the SLC39 gene family	4.933213e-01	0.307
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	4.972272e-01	0.303
R-HSA-9646399	Aggrephagy	4.972272e-01	0.303
R-HSA-167169	HIV Transcription Elongation	4.972272e-01	0.303
R-HSA-5260271	Diseases of Immune System	4.972272e-01	0.303
R-HSA-5602358	Diseases associated with the TLR signaling cascade	4.972272e-01	0.303
R-HSA-3858494	Beta-catenin independent WNT signaling	4.999242e-01	0.301
R-HSA-933542	TRAF6 mediated NF-kB activation	5.066657e-01	0.295
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	5.066657e-01	0.295
R-HSA-429947	Deadenylation of mRNA	5.066657e-01	0.295
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	5.066657e-01	0.295
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	5.111578e-01	0.291
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	5.111578e-01	0.291
R-HSA-8853884	Transcriptional Regulation by VENTX	5.111578e-01	0.291
R-HSA-9772572	Early SARS-CoV-2 Infection Events	5.140502e-01	0.289
R-HSA-2672351	Stimuli-sensing channels	5.199658e-01	0.284
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	5.212409e-01	0.283
R-HSA-173107	Binding and entry of HIV virion	5.212409e-01	0.283
R-HSA-6803544	Ion influx/efflux at host-pathogen interface	5.212409e-01	0.283
R-HSA-198203	PI3K/AKT activation	5.212409e-01	0.283
R-HSA-8875555	MET activates RAP1 and RAC1	5.212409e-01	0.283
R-HSA-2179392	EGFR Transactivation by Gastrin	5.212409e-01	0.283
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	5.212409e-01	0.283
R-HSA-164843	2-LTR circle formation	5.212409e-01	0.283
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN...	5.212409e-01	0.283
R-HSA-9693928	Defective RIPK1-mediated regulated necrosis	5.212409e-01	0.283
R-HSA-9683686	Maturation of spike protein	5.212409e-01	0.283
R-HSA-6799990	Metal sequestration by antimicrobial proteins	5.212409e-01	0.283
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription	5.212409e-01	0.283
R-HSA-5684996	MAPK1/MAPK3 signaling	5.225025e-01	0.282
R-HSA-3214842	HDMs demethylate histones	5.240731e-01	0.281
R-HSA-70221	Glycogen breakdown (glycogenolysis)	5.240731e-01	0.281
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	5.240731e-01	0.281
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	5.240731e-01	0.281
R-HSA-5675221	Negative regulation of MAPK pathway	5.248817e-01	0.280
R-HSA-9615017	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	5.248817e-01	0.280
R-HSA-5619084	ABC transporter disorders	5.369428e-01	0.270
R-HSA-165159	MTOR signalling	5.383905e-01	0.269
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	5.393063e-01	0.268
R-HSA-525793	Myogenesis	5.410617e-01	0.267
R-HSA-3295583	TRP channels	5.410617e-01	0.267
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	5.410617e-01	0.267
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	5.410617e-01	0.267
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	5.462264e-01	0.263
R-HSA-8932505	DAG1 core M3 glycosylations	5.476236e-01	0.262
R-HSA-4839744	Signaling by APC mutants	5.476236e-01	0.262
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	5.476236e-01	0.262
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	5.476236e-01	0.262
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	5.476236e-01	0.262
R-HSA-177135	Conjugation of benzoate with glycine	5.476236e-01	0.262
R-HSA-192905	vRNP Assembly	5.476236e-01	0.262
R-HSA-192814	vRNA Synthesis	5.476236e-01	0.262
R-HSA-9706019	RHOBTB3 ATPase cycle	5.476236e-01	0.262
R-HSA-9645460	Alpha-protein kinase 1 signaling pathway	5.476236e-01	0.262
R-HSA-9754560	SARS-CoV-2 modulates autophagy	5.476236e-01	0.262
R-HSA-196819	Vitamin B1 (thiamin) metabolism	5.476236e-01	0.262
R-HSA-427601	Inorganic anion exchange by SLC26 transporters	5.476236e-01	0.262
R-HSA-9662834	CD163 mediating an anti-inflammatory response	5.476236e-01	0.262
R-HSA-168325	Viral Messenger RNA Synthesis	5.487109e-01	0.261
R-HSA-8939902	Regulation of RUNX2 expression and activity	5.487109e-01	0.261
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	5.531379e-01	0.257
R-HSA-174414	Processive synthesis on the C-strand of the telomere	5.576247e-01	0.254
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	5.576247e-01	0.254
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	5.576247e-01	0.254
R-HSA-8949613	Cristae formation	5.576247e-01	0.254
R-HSA-389357	CD28 dependent PI3K/Akt signaling	5.576247e-01	0.254
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	5.576247e-01	0.254
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	5.599737e-01	0.252
R-HSA-190828	Gap junction trafficking	5.647335e-01	0.248
R-HSA-2514853	Condensation of Prometaphase Chromosomes	5.725539e-01	0.242
R-HSA-1250342	PI3K events in ERBB4 signaling	5.725539e-01	0.242
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	5.725539e-01	0.242
R-HSA-162592	Integration of provirus	5.725539e-01	0.242
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	5.725539e-01	0.242
R-HSA-68884	Mitotic Telophase/Cytokinesis	5.725539e-01	0.242
R-HSA-4839735	Signaling by AXIN mutants	5.725539e-01	0.242
R-HSA-4839748	Signaling by AMER1 mutants	5.725539e-01	0.242
R-HSA-418359	Reduction of cytosolic Ca++ levels	5.725539e-01	0.242
R-HSA-168330	Viral RNP Complexes in the Host Cell Nucleus	5.725539e-01	0.242
R-HSA-180689	APOBEC3G mediated resistance to HIV-1 infection	5.725539e-01	0.242
R-HSA-9619483	Activation of AMPK downstream of NMDARs	5.737576e-01	0.241
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	5.737576e-01	0.241
R-HSA-622312	Inflammasomes	5.737576e-01	0.241
R-HSA-8957275	Post-translational protein phosphorylation	5.823540e-01	0.235
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	5.894573e-01	0.230
R-HSA-72165	mRNA Splicing - Minor Pathway	5.901370e-01	0.229
R-HSA-9843745	Adipogenesis	5.922773e-01	0.227
R-HSA-1234174	Cellular response to hypoxia	5.928200e-01	0.227
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	5.961117e-01	0.225
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	5.961117e-01	0.225
R-HSA-4641265	Repression of WNT target genes	5.961117e-01	0.225
R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	5.961117e-01	0.225
R-HSA-177128	Conjugation of salicylate with glycine	5.961117e-01	0.225
R-HSA-1679131	Trafficking and processing of endosomal TLR	5.961117e-01	0.225
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	5.961117e-01	0.225
R-HSA-9820865	Z-decay: degradation of maternal mRNAs by zygotically expressed factors	5.961117e-01	0.225
R-HSA-9842663	Signaling by LTK	5.961117e-01	0.225
R-HSA-9909396	Circadian clock	5.998233e-01	0.222
R-HSA-382556	ABC-family proteins mediated transport	5.998577e-01	0.222
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation	6.024745e-01	0.220
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	6.047227e-01	0.218
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	6.047227e-01	0.218
R-HSA-888590	GABA synthesis, release, reuptake and degradation	6.047227e-01	0.218
R-HSA-6794362	Protein-protein interactions at synapses	6.056670e-01	0.218
R-HSA-392499	Metabolism of proteins	6.099038e-01	0.215
R-HSA-1257604	PIP3 activates AKT signaling	6.123346e-01	0.213
R-HSA-9031628	NGF-stimulated transcription	6.145645e-01	0.211
R-HSA-9735804	Diseases of nucleotide metabolism	6.183726e-01	0.209
R-HSA-9682706	Replication of the SARS-CoV-1 genome	6.183726e-01	0.209
R-HSA-162588	Budding and maturation of HIV virion	6.195539e-01	0.208
R-HSA-5694530	Cargo concentration in the ER	6.195539e-01	0.208
R-HSA-163841	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	6.241961e-01	0.205
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	6.264040e-01	0.203
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	6.264040e-01	0.203
R-HSA-111885	Opioid Signalling	6.336429e-01	0.198
R-HSA-4791275	Signaling by WNT in cancer	6.339524e-01	0.198
R-HSA-9937080	Developmental Lineage of Multipotent Pancreatic Progenitor Cells	6.339524e-01	0.198
R-HSA-9679506	SARS-CoV Infections	6.384735e-01	0.195
R-HSA-69166	Removal of the Flap Intermediate	6.394078e-01	0.194
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	6.394078e-01	0.194
R-HSA-399956	CRMPs in Sema3A signaling	6.394078e-01	0.194
R-HSA-9018681	Biosynthesis of protectins	6.394078e-01	0.194
R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	6.394078e-01	0.194
R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	6.394078e-01	0.194
R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	6.394078e-01	0.194
R-HSA-5655291	Signaling by FGFR4 in disease	6.394078e-01	0.194
R-HSA-196843	Vitamin B2 (riboflavin) metabolism	6.394078e-01	0.194
R-HSA-5578768	Physiological factors	6.394078e-01	0.194
R-HSA-9023661	Biosynthesis of E-series 18(R)-resolvins	6.394078e-01	0.194
R-HSA-9828642	Respiratory syncytial virus genome transcription	6.394078e-01	0.194
R-HSA-1433559	Regulation of KIT signaling	6.394078e-01	0.194
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	6.394078e-01	0.194
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	6.394078e-01	0.194
R-HSA-1482798	Acyl chain remodeling of CL	6.394078e-01	0.194
R-HSA-435354	Zinc transporters	6.394078e-01	0.194
R-HSA-9679514	SARS-CoV-1 Genome Replication and Transcription	6.394078e-01	0.194
R-HSA-9833110	RSV-host interactions	6.418224e-01	0.193
R-HSA-9759194	Nuclear events mediated by NFE2L2	6.424005e-01	0.192
R-HSA-9705683	SARS-CoV-2-host interactions	6.475673e-01	0.189
R-HSA-9668328	Sealing of the nuclear envelope (NE) by ESCRT-III	6.479208e-01	0.188
R-HSA-168256	Immune System	6.559889e-01	0.183
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	6.592847e-01	0.181
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	6.592847e-01	0.181
R-HSA-6785631	ERBB2 Regulates Cell Motility	6.592847e-01	0.181
R-HSA-69183	Processive synthesis on the lagging strand	6.592847e-01	0.181
R-HSA-1502540	Signaling by Activin	6.592847e-01	0.181
R-HSA-9673767	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	6.592847e-01	0.181
R-HSA-9673770	Signaling by PDGFRA extracellular domain mutants	6.592847e-01	0.181
R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	6.592847e-01	0.181
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	6.592847e-01	0.181
R-HSA-8876725	Protein methylation	6.592847e-01	0.181
R-HSA-418885	DCC mediated attractive signaling	6.592847e-01	0.181
R-HSA-6794361	Neurexins and neuroligins	6.604020e-01	0.180
R-HSA-9692916	SARS-CoV-1 activates/modulates innate immune responses	6.604020e-01	0.180
R-HSA-9634815	Transcriptional Regulation by NPAS4	6.604020e-01	0.180
R-HSA-5339562	Uptake and actions of bacterial toxins	6.604020e-01	0.180
R-HSA-9768727	Regulation of CDH1 posttranslational processing and trafficking to plasma membra...	6.614628e-01	0.179
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	6.614628e-01	0.179
R-HSA-8964539	Glutamate and glutamine metabolism	6.614628e-01	0.179
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	6.623726e-01	0.179
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	6.635159e-01	0.178
R-HSA-8956320	Nucleotide biosynthesis	6.712246e-01	0.173
R-HSA-4086398	Ca2+ pathway	6.729013e-01	0.172
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	6.729013e-01	0.172
R-HSA-901042	Calnexin/calreticulin cycle	6.745829e-01	0.171
R-HSA-9768919	NPAS4 regulates expression of target genes	6.745829e-01	0.171
R-HSA-381070	IRE1alpha activates chaperones	6.765373e-01	0.170
R-HSA-5083636	Defective GALNT12 causes CRCS1	6.780671e-01	0.169
R-HSA-5083625	Defective GALNT3 causes HFTC	6.780671e-01	0.169
R-HSA-9603798	Class I peroxisomal membrane protein import	6.780671e-01	0.169
R-HSA-169893	Prolonged ERK activation events	6.780671e-01	0.169
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	6.780671e-01	0.169
R-HSA-9664420	Killing mechanisms	6.780671e-01	0.169
R-HSA-9758274	Regulation of NF-kappa B signaling	6.780671e-01	0.169
R-HSA-388844	Receptor-type tyrosine-protein phosphatases	6.780671e-01	0.169
R-HSA-5635838	Activation of SMO	6.780671e-01	0.169
R-HSA-9706369	Negative regulation of FLT3	6.780671e-01	0.169
R-HSA-168268	Virus Assembly and Release	6.780671e-01	0.169
R-HSA-1226099	Signaling by FGFR in disease	6.821043e-01	0.166
R-HSA-381042	PERK regulates gene expression	6.872866e-01	0.163
R-HSA-71403	Citric acid cycle (TCA cycle)	6.911241e-01	0.160
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	6.911241e-01	0.160
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	6.921044e-01	0.160
R-HSA-1963640	GRB2 events in ERBB2 signaling	6.958152e-01	0.158
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL...	6.958152e-01	0.158
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	6.958152e-01	0.158
R-HSA-918233	TRAF3-dependent IRF activation pathway	6.958152e-01	0.158
R-HSA-9027307	Biosynthesis of maresin-like SPMs	6.958152e-01	0.158
R-HSA-77288	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6.958152e-01	0.158
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	6.958152e-01	0.158
R-HSA-399997	Acetylcholine regulates insulin secretion	6.958152e-01	0.158
R-HSA-6787450	tRNA modification in the mitochondrion	6.958152e-01	0.158
R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6.958152e-01	0.158
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	6.995797e-01	0.155
R-HSA-74158	RNA Polymerase III Transcription	6.995797e-01	0.155
R-HSA-8941326	RUNX2 regulates bone development	6.995797e-01	0.155
R-HSA-187037	Signaling by NTRK1 (TRKA)	6.996662e-01	0.155
R-HSA-75893	TNF signaling	7.021630e-01	0.154
R-HSA-948021	Transport to the Golgi and subsequent modification	7.061524e-01	0.151
R-HSA-933541	TRAF6 mediated IRF7 activation	7.114690e-01	0.148
R-HSA-196757	Metabolism of folate and pterines	7.114690e-01	0.148
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	7.125858e-01	0.147
R-HSA-5083632	Defective C1GALT1C1 causes TNPS	7.125858e-01	0.147
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	7.125858e-01	0.147
R-HSA-9020265	Biosynthesis of aspirin-triggered D-series resolvins	7.125858e-01	0.147
R-HSA-9768759	Regulation of NPAS4 gene expression	7.125858e-01	0.147
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	7.125858e-01	0.147
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	7.125858e-01	0.147
R-HSA-5210891	Uptake and function of anthrax toxins	7.125858e-01	0.147
R-HSA-9694686	Replication of the SARS-CoV-2 genome	7.125858e-01	0.147
R-HSA-74217	Purine salvage	7.229616e-01	0.141
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	7.237936e-01	0.140
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	7.242698e-01	0.140
R-HSA-597592	Post-translational protein modification	7.266650e-01	0.139
R-HSA-73980	RNA Polymerase III Transcription Termination	7.284328e-01	0.138
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	7.284328e-01	0.138
R-HSA-190872	Transport of connexons to the plasma membrane	7.284328e-01	0.138
R-HSA-180292	GAB1 signalosome	7.284328e-01	0.138
R-HSA-8849932	Synaptic adhesion-like molecules	7.284328e-01	0.138
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	7.284328e-01	0.138
R-HSA-6804760	Regulation of TP53 Activity through Methylation	7.284328e-01	0.138
R-HSA-210993	Tie2 Signaling	7.284328e-01	0.138
R-HSA-5358508	Mismatch Repair	7.284328e-01	0.138
R-HSA-429914	Deadenylation-dependent mRNA decay	7.308312e-01	0.136
R-HSA-352230	Amino acid transport across the plasma membrane	7.308312e-01	0.136
R-HSA-8856688	Golgi-to-ER retrograde transport	7.322447e-01	0.135
R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR...	7.334769e-01	0.135
R-HSA-6806834	Signaling by MET	7.334769e-01	0.135
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	7.340651e-01	0.134
R-HSA-983189	Kinesins	7.398915e-01	0.131
R-HSA-9755511	KEAP1-NFE2L2 pathway	7.400513e-01	0.131
R-HSA-5654710	PI-3K cascade:FGFR3	7.434069e-01	0.129
R-HSA-937041	IKK complex recruitment mediated by RIP1	7.434069e-01	0.129
R-HSA-912631	Regulation of signaling by CBL	7.434069e-01	0.129
R-HSA-9834899	Specification of the neural plate border	7.434069e-01	0.129
R-HSA-156587	Amino Acid conjugation	7.434069e-01	0.129
R-HSA-159424	Conjugation of carboxylic acids	7.434069e-01	0.129
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	7.434069e-01	0.129
R-HSA-392517	Rap1 signalling	7.434069e-01	0.129
R-HSA-1912420	Pre-NOTCH Processing in Golgi	7.434069e-01	0.129
R-HSA-9913635	Strand-asynchronous mitochondrial DNA replication	7.434069e-01	0.129
R-HSA-9694682	SARS-CoV-2 Genome Replication and Transcription	7.434069e-01	0.129
R-HSA-9854311	Maturation of TCA enzymes and regulation of TCA cycle	7.447874e-01	0.128
R-HSA-202433	Generation of second messenger molecules	7.447874e-01	0.128
R-HSA-8982491	Glycogen metabolism	7.447874e-01	0.128
R-HSA-9614085	FOXO-mediated transcription	7.454828e-01	0.128
R-HSA-193704	p75 NTR receptor-mediated signalling	7.454828e-01	0.128
R-HSA-5621481	C-type lectin receptors (CLRs)	7.476247e-01	0.126
R-HSA-5610787	Hedgehog 'off' state	7.524264e-01	0.124
R-HSA-9607240	FLT3 Signaling	7.551369e-01	0.122
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	7.567105e-01	0.121
R-HSA-73887	Death Receptor Signaling	7.569956e-01	0.121
R-HSA-5654720	PI-3K cascade:FGFR4	7.575562e-01	0.121
R-HSA-5620916	VxPx cargo-targeting to cilium	7.575562e-01	0.121
R-HSA-389977	Post-chaperonin tubulin folding pathway	7.575562e-01	0.121
R-HSA-1181150	Signaling by NODAL	7.575562e-01	0.121
R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	7.575562e-01	0.121
R-HSA-196108	Pregnenolone biosynthesis	7.575562e-01	0.121
R-HSA-140875	Common Pathway of Fibrin Clot Formation	7.575562e-01	0.121
R-HSA-3322077	Glycogen synthesis	7.575562e-01	0.121
R-HSA-983169	Class I MHC mediated antigen processing & presentation	7.578698e-01	0.120
R-HSA-1643685	Disease	7.583250e-01	0.120
R-HSA-168249	Innate Immune System	7.591800e-01	0.120
R-HSA-5683057	MAPK family signaling cascades	7.619094e-01	0.118
R-HSA-8878166	Transcriptional regulation by RUNX2	7.632359e-01	0.117
R-HSA-3000480	Scavenging by Class A Receptors	7.651219e-01	0.116
R-HSA-1483255	PI Metabolism	7.658881e-01	0.116
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	7.700524e-01	0.113
R-HSA-5602498	MyD88 deficiency (TLR2/4)	7.709261e-01	0.113
R-HSA-9939291	Matriglycan biosynthesis on DAG1	7.709261e-01	0.113
R-HSA-5357786	TNFR1-induced proapoptotic signaling	7.709261e-01	0.113
R-HSA-9018896	Biosynthesis of E-series 18(S)-resolvins	7.709261e-01	0.113
R-HSA-5687128	MAPK6/MAPK4 signaling	7.713101e-01	0.113
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	7.747512e-01	0.111
R-HSA-9909615	Regulation of PD-L1(CD274) Post-translational modification	7.783477e-01	0.109
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	7.783503e-01	0.109
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	7.835595e-01	0.106
R-HSA-9671555	Signaling by PDGFR in disease	7.835595e-01	0.106
R-HSA-9825892	Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	7.835595e-01	0.106
R-HSA-977347	Serine metabolism	7.835595e-01	0.106
R-HSA-9034015	Signaling by NTRK3 (TRKC)	7.835595e-01	0.106
R-HSA-9755088	Ribavirin ADME	7.835595e-01	0.106
R-HSA-8854214	TBC/RABGAPs	7.840337e-01	0.106
R-HSA-1433557	Signaling by SCF-KIT	7.840337e-01	0.106
R-HSA-9664422	FCGR3A-mediated phagocytosis	7.845175e-01	0.105
R-HSA-9664407	Parasite infection	7.845175e-01	0.105
R-HSA-9664417	Leishmania phagocytosis	7.845175e-01	0.105
R-HSA-381038	XBP1(S) activates chaperone genes	7.852129e-01	0.105
R-HSA-9006936	Signaling by TGFB family members	7.885006e-01	0.103
R-HSA-373752	Netrin-1 signaling	7.929783e-01	0.101
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	7.929783e-01	0.101
R-HSA-5654689	PI-3K cascade:FGFR1	7.954968e-01	0.099
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	7.954968e-01	0.099
R-HSA-6803529	FGFR2 alternative splicing	7.954968e-01	0.099
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	7.954968e-01	0.099
R-HSA-3238698	WNT ligand biogenesis and trafficking	7.954968e-01	0.099
R-HSA-9018676	Biosynthesis of D-series resolvins	7.954968e-01	0.099
R-HSA-9670439	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m...	7.954968e-01	0.099
R-HSA-5652084	Fructose metabolism	7.954968e-01	0.099
R-HSA-112409	RAF-independent MAPK1/3 activation	7.954968e-01	0.099
R-HSA-9669938	Signaling by KIT in disease	7.954968e-01	0.099
R-HSA-9958863	SLC-mediated transport of amino acids	7.966630e-01	0.099
R-HSA-6783310	Fanconi Anemia Pathway	8.015940e-01	0.096
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	8.067765e-01	0.093
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	8.067765e-01	0.093
R-HSA-977068	Termination of O-glycan biosynthesis	8.067765e-01	0.093
R-HSA-9830674	Formation of the ureteric bud	8.067765e-01	0.093
R-HSA-9648895	Response of EIF2AK1 (HRI) to heme deficiency	8.067765e-01	0.093
R-HSA-9018682	Biosynthesis of maresins	8.067765e-01	0.093
R-HSA-912526	Interleukin receptor SHC signaling	8.067765e-01	0.093
R-HSA-9937008	Mitochondrial mRNA modification	8.067765e-01	0.093
R-HSA-200425	Carnitine shuttle	8.067765e-01	0.093
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	8.083780e-01	0.092
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	8.086351e-01	0.092
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	8.098899e-01	0.092
R-HSA-5357905	Regulation of TNFR1 signaling	8.098899e-01	0.092
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	8.098899e-01	0.092
R-HSA-9660826	Purinergic signaling in leishmaniasis infection	8.098899e-01	0.092
R-HSA-9664424	Cell recruitment (pro-inflammatory response)	8.098899e-01	0.092
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	8.108507e-01	0.091
R-HSA-8986944	Transcriptional Regulation by MECP2	8.170249e-01	0.088
R-HSA-211999	CYP2E1 reactions	8.174346e-01	0.088
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	8.174346e-01	0.088
R-HSA-9836573	Mitochondrial RNA degradation	8.174346e-01	0.088
R-HSA-9703648	Signaling by FLT3 ITD and TKD mutants	8.174346e-01	0.088
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	8.176252e-01	0.087
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	8.178750e-01	0.087
R-HSA-389356	Co-stimulation by CD28	8.255584e-01	0.083
R-HSA-5654695	PI-3K cascade:FGFR2	8.275055e-01	0.082
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	8.275055e-01	0.082
R-HSA-1296059	G protein gated Potassium channels	8.275055e-01	0.082
R-HSA-1296041	Activation of G protein gated Potassium channels	8.275055e-01	0.082
R-HSA-420029	Tight junction interactions	8.275055e-01	0.082
R-HSA-9839394	TGFBR3 expression	8.275055e-01	0.082
R-HSA-1482801	Acyl chain remodelling of PS	8.275055e-01	0.082
R-HSA-9830364	Formation of the nephric duct	8.275055e-01	0.082
R-HSA-1266695	Interleukin-7 signaling	8.275055e-01	0.082
R-HSA-3000157	Laminin interactions	8.275055e-01	0.082
R-HSA-166520	Signaling by NTRKs	8.287785e-01	0.082
R-HSA-9711123	Cellular response to chemical stress	8.290217e-01	0.081
R-HSA-1483249	Inositol phosphate metabolism	8.301317e-01	0.081
R-HSA-9924644	Developmental Lineages of the Mammary Gland	8.305565e-01	0.081
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	8.370214e-01	0.077
R-HSA-70635	Urea cycle	8.370214e-01	0.077
R-HSA-8934593	Regulation of RUNX1 Expression and Activity	8.370214e-01	0.077
R-HSA-72306	tRNA processing	8.382173e-01	0.077
R-HSA-109704	PI3K Cascade	8.400557e-01	0.076
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	8.460129e-01	0.073
R-HSA-5655332	Signaling by FGFR3 in disease	8.460129e-01	0.073
R-HSA-201451	Signaling by BMP	8.460129e-01	0.073
R-HSA-9006115	Signaling by NTRK2 (TRKB)	8.460129e-01	0.073
R-HSA-2514856	The phototransduction cascade	8.468874e-01	0.072
R-HSA-9609507	Protein localization	8.500882e-01	0.071
R-HSA-1980143	Signaling by NOTCH1	8.540690e-01	0.069
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	8.545088e-01	0.068
R-HSA-113418	Formation of the Early Elongation Complex	8.545088e-01	0.068
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	8.545088e-01	0.068
R-HSA-171319	Telomere Extension By Telomerase	8.545088e-01	0.068
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	8.549515e-01	0.068
R-HSA-1296071	Potassium Channels	8.549515e-01	0.068
R-HSA-1280218	Adaptive Immune System	8.551119e-01	0.068
R-HSA-72086	mRNA Capping	8.625365e-01	0.064
R-HSA-5654708	Downstream signaling of activated FGFR3	8.625365e-01	0.064
R-HSA-180024	DARPP-32 events	8.625365e-01	0.064
R-HSA-9006335	Signaling by Erythropoietin	8.625365e-01	0.064
R-HSA-418360	Platelet calcium homeostasis	8.625365e-01	0.064
R-HSA-9018679	Biosynthesis of EPA-derived SPMs	8.625365e-01	0.064
R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	8.658185e-01	0.063
R-HSA-2219528	PI3K/AKT Signaling in Cancer	8.672220e-01	0.062
R-HSA-5654716	Downstream signaling of activated FGFR4	8.701217e-01	0.060
R-HSA-9008059	Interleukin-37 signaling	8.701217e-01	0.060
R-HSA-76046	RNA Polymerase III Transcription Initiation	8.701217e-01	0.060
R-HSA-114452	Activation of BH3-only proteins	8.701217e-01	0.060
R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	8.701217e-01	0.060
R-HSA-2424491	DAP12 signaling	8.701217e-01	0.060
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	8.713696e-01	0.060
R-HSA-5358351	Signaling by Hedgehog	8.714008e-01	0.060
R-HSA-112315	Transmission across Chemical Synapses	8.735805e-01	0.059
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	8.772888e-01	0.057
R-HSA-9820960	Respiratory syncytial virus (RSV) attachment and entry	8.772888e-01	0.057
R-HSA-9833109	Evasion by RSV of host interferon responses	8.772888e-01	0.057
R-HSA-186763	Downstream signal transduction	8.772888e-01	0.057
R-HSA-2129379	Molecules associated with elastic fibres	8.772888e-01	0.057
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	8.807540e-01	0.055
R-HSA-112399	IRS-mediated signalling	8.825794e-01	0.054
R-HSA-8931838	DAG1 glycosylations	8.840607e-01	0.054
R-HSA-2132295	MHC class II antigen presentation	8.867495e-01	0.052
R-HSA-9694516	SARS-CoV-2 Infection	8.876223e-01	0.052
R-HSA-9860931	Response of endothelial cells to shear stress	8.899052e-01	0.051
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	8.904594e-01	0.050
R-HSA-5609975	Diseases associated with glycosylation precursor biosynthesis	8.904594e-01	0.050
R-HSA-9033241	Peroxisomal protein import	8.926545e-01	0.049
R-HSA-186712	Regulation of beta-cell development	8.926545e-01	0.049
R-HSA-2871837	FCERI mediated NF-kB activation	8.957086e-01	0.048
R-HSA-9818027	NFE2L2 regulating anti-oxidant/detoxification enzymes	8.965053e-01	0.047
R-HSA-5223345	Miscellaneous transport and binding events	8.965053e-01	0.047
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	8.973853e-01	0.047
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	8.973853e-01	0.047
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	8.973853e-01	0.047
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	8.973853e-01	0.047
R-HSA-2644603	Signaling by NOTCH1 in Cancer	8.973853e-01	0.047
R-HSA-2428928	IRS-related events triggered by IGF1R	9.019212e-01	0.045
R-HSA-8956321	Nucleotide salvage	9.019212e-01	0.045
R-HSA-5205647	Mitophagy	9.022178e-01	0.045
R-HSA-203615	eNOS activation	9.022178e-01	0.045
R-HSA-5686938	Regulation of TLR by endogenous ligand	9.022178e-01	0.045
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	9.022178e-01	0.045
R-HSA-190861	Gap junction assembly	9.022178e-01	0.045
R-HSA-2393930	Phosphate bond hydrolysis by NUDT proteins	9.022178e-01	0.045
R-HSA-375165	NCAM signaling for neurite out-growth	9.062695e-01	0.043
R-HSA-917977	Transferrin endocytosis and recycling	9.076154e-01	0.042
R-HSA-5654696	Downstream signaling of activated FGFR2	9.076154e-01	0.042
R-HSA-5654687	Downstream signaling of activated FGFR1	9.076154e-01	0.042
R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ...	9.076154e-01	0.042
R-HSA-70268	Pyruvate metabolism	9.083100e-01	0.042
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	9.104370e-01	0.041
R-HSA-8848021	Signaling by PTK6	9.104370e-01	0.041
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	9.104370e-01	0.041
R-HSA-9845576	Glycosphingolipid transport	9.127153e-01	0.040
R-HSA-114604	GPVI-mediated activation cascade	9.127153e-01	0.040
R-HSA-163560	Triglyceride catabolism	9.127153e-01	0.040
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	9.127153e-01	0.040
R-HSA-2428924	IGF1R signaling cascade	9.144303e-01	0.039
R-HSA-74751	Insulin receptor signalling cascade	9.144303e-01	0.039
R-HSA-1296072	Voltage gated Potassium channels	9.175340e-01	0.037
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	9.182561e-01	0.037
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	9.185768e-01	0.037
R-HSA-112310	Neurotransmitter release cycle	9.186515e-01	0.037
R-HSA-6785470	tRNA processing in the mitochondrion	9.220869e-01	0.035
R-HSA-8875878	MET promotes cell motility	9.220869e-01	0.035
R-HSA-1566948	Elastic fibre formation	9.220869e-01	0.035
R-HSA-112316	Neuronal System	9.225001e-01	0.035
R-HSA-9734767	Developmental Cell Lineages	9.253392e-01	0.034
R-HSA-9830369	Kidney development	9.254300e-01	0.034
R-HSA-9855142	Cellular responses to mechanical stimuli	9.258379e-01	0.033
R-HSA-1989781	PPARA activates gene expression	9.259510e-01	0.033
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	9.263887e-01	0.033
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	9.263887e-01	0.033
R-HSA-71336	Pentose phosphate pathway	9.263887e-01	0.033
R-HSA-201556	Signaling by ALK	9.263887e-01	0.033
R-HSA-611105	Respiratory electron transport	9.288258e-01	0.032
R-HSA-8868766	rRNA processing in the mitochondrion	9.304533e-01	0.031
R-HSA-451927	Interleukin-2 family signaling	9.304533e-01	0.031
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	9.305350e-01	0.031
R-HSA-163685	Integration of energy metabolism	9.335339e-01	0.030
R-HSA-9694548	Maturation of spike protein	9.342936e-01	0.030
R-HSA-71291	Metabolism of amino acids and derivatives	9.344560e-01	0.029
R-HSA-204005	COPII-mediated vesicle transport	9.350858e-01	0.029
R-HSA-9683701	Translation of Structural Proteins	9.379221e-01	0.028
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	9.380323e-01	0.028
R-HSA-3000178	ECM proteoglycans	9.380323e-01	0.028
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	9.408515e-01	0.026
R-HSA-991365	Activation of GABAB receptors	9.413505e-01	0.026
R-HSA-977444	GABA B receptor activation	9.413505e-01	0.026
R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	9.413505e-01	0.026
R-HSA-400508	Incretin synthesis, secretion, and inactivation	9.413505e-01	0.026
R-HSA-9749641	Aspirin ADME	9.435487e-01	0.025
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	9.445897e-01	0.025
R-HSA-5654743	Signaling by FGFR4	9.445897e-01	0.025
R-HSA-9637690	Response of Mtb to phagocytosis	9.445897e-01	0.025
R-HSA-156581	Methylation	9.476502e-01	0.023
R-HSA-2172127	DAP12 interactions	9.476502e-01	0.023
R-HSA-917937	Iron uptake and transport	9.485959e-01	0.023
R-HSA-77286	mitochondrial fatty acid beta-oxidation of saturated fatty acids	9.505418e-01	0.022
R-HSA-5654741	Signaling by FGFR3	9.505418e-01	0.022
R-HSA-9024446	NR1H2 and NR1H3-mediated signaling	9.532109e-01	0.021
R-HSA-9861718	Regulation of pyruvate metabolism	9.532739e-01	0.021
R-HSA-9839373	Signaling by TGFBR3	9.532739e-01	0.021
R-HSA-8955332	Carboxyterminal post-translational modifications of tubulin	9.558552e-01	0.020
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	9.574284e-01	0.019
R-HSA-5620924	Intraflagellar transport	9.582940e-01	0.019
R-HSA-425410	Metal ion SLC transporters	9.582940e-01	0.019
R-HSA-5654738	Signaling by FGFR2	9.593982e-01	0.018
R-HSA-380108	Chemokine receptors bind chemokines	9.605983e-01	0.017
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	9.608341e-01	0.017
R-HSA-9018677	Biosynthesis of DHA-derived SPMs	9.612804e-01	0.017
R-HSA-5655253	Signaling by FGFR2 in disease	9.627753e-01	0.016
R-HSA-9748787	Azathioprine ADME	9.627753e-01	0.016
R-HSA-9864848	Complex IV assembly	9.648322e-01	0.016
R-HSA-156584	Cytosolic sulfonation of small molecules	9.648322e-01	0.016
R-HSA-5619115	Disorders of transmembrane transporters	9.659347e-01	0.015
R-HSA-5419276	Mitochondrial translation termination	9.673504e-01	0.014
R-HSA-9639288	Amino acids regulate mTORC1	9.686117e-01	0.014
R-HSA-877300	Interferon gamma signaling	9.718225e-01	0.012
R-HSA-9753281	Paracetamol ADME	9.719854e-01	0.012
R-HSA-5654736	Signaling by FGFR1	9.735338e-01	0.012
R-HSA-5621480	Dectin-2 family	9.749968e-01	0.011
R-HSA-9658195	Leishmania infection	9.754980e-01	0.011
R-HSA-9824443	Parasitic Infection Pathways	9.754980e-01	0.011
R-HSA-5628897	TP53 Regulates Metabolic Genes	9.758531e-01	0.011
R-HSA-15869	Metabolism of nucleotides	9.768467e-01	0.010
R-HSA-2029485	Role of phospholipids in phagocytosis	9.768805e-01	0.010
R-HSA-8979227	Triglyceride metabolism	9.776848e-01	0.010
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	9.776848e-01	0.010
R-HSA-9007101	Rab regulation of trafficking	9.788120e-01	0.009
R-HSA-977443	GABA receptor activation	9.789186e-01	0.009
R-HSA-74752	Signaling by Insulin receptor	9.792718e-01	0.009
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messenge...	9.802554e-01	0.009
R-HSA-186797	Signaling by PDGF	9.811854e-01	0.008
R-HSA-9707616	Heme signaling	9.811854e-01	0.008
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	9.811936e-01	0.008
R-HSA-1474290	Collagen formation	9.811936e-01	0.008
R-HSA-6799198	Complex I biogenesis	9.822258e-01	0.008
R-HSA-211981	Xenobiotics	9.832087e-01	0.007
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	9.837257e-01	0.007
R-HSA-5389840	Mitochondrial translation elongation	9.837562e-01	0.007
R-HSA-1428517	Aerobic respiration and respiratory electron transport	9.837833e-01	0.007
R-HSA-5368286	Mitochondrial translation initiation	9.852725e-01	0.006
R-HSA-190236	Signaling by FGFR	9.852725e-01	0.006
R-HSA-422356	Regulation of insulin secretion	9.852725e-01	0.006
R-HSA-196071	Metabolism of steroid hormones	9.858435e-01	0.006
R-HSA-913709	O-linked glycosylation of mucins	9.866265e-01	0.006
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	9.866265e-01	0.006
R-HSA-9009391	Extra-nuclear estrogen signaling	9.872920e-01	0.006
R-HSA-75105	Fatty acyl-CoA biosynthesis	9.880652e-01	0.005
R-HSA-9937383	Mitochondrial ribosome-associated quality control	9.884857e-01	0.005
R-HSA-199418	Negative regulation of the PI3K/AKT network	9.886056e-01	0.005
R-HSA-8978934	Metabolism of cofactors	9.887255e-01	0.005
R-HSA-1474244	Extracellular matrix organization	9.891204e-01	0.005
R-HSA-74259	Purine catabolism	9.893492e-01	0.005
R-HSA-1236394	Signaling by ERBB4	9.904953e-01	0.004
R-HSA-1222556	ROS and RNS production in phagocytes	9.904953e-01	0.004
R-HSA-9694635	Translation of Structural Proteins	9.919876e-01	0.003
R-HSA-109582	Hemostasis	9.920044e-01	0.003
R-HSA-216083	Integrin cell surface interactions	9.924310e-01	0.003
R-HSA-6803157	Antimicrobial peptides	9.926348e-01	0.003
R-HSA-5368287	Mitochondrial translation	9.927523e-01	0.003
R-HSA-9925561	Developmental Lineage of Pancreatic Acinar Cells	9.928500e-01	0.003
R-HSA-5619102	SLC transporter disorders	9.929625e-01	0.003
R-HSA-2871796	FCERI mediated MAPK activation	9.929935e-01	0.003
R-HSA-8951664	Neddylation	9.933006e-01	0.003
R-HSA-9707564	Cytoprotection by HMOX1	9.943066e-01	0.002
R-HSA-446203	Asparagine N-linked glycosylation	9.943419e-01	0.002
R-HSA-909733	Interferon alpha/beta signaling	9.945456e-01	0.002
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	9.952009e-01	0.002
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	9.952669e-01	0.002
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	9.957528e-01	0.002
R-HSA-373080	Class B/2 (Secretin family receptors)	9.963906e-01	0.002
R-HSA-416476	G alpha (q) signalling events	9.964274e-01	0.002
R-HSA-6809371	Formation of the cornified envelope	9.965356e-01	0.002
R-HSA-977606	Regulation of Complement cascade	9.967067e-01	0.001
R-HSA-9772573	Late SARS-CoV-2 Infection Events	9.969578e-01	0.001
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	9.974360e-01	0.001
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	9.977123e-01	0.001
R-HSA-5173105	O-linked glycosylation	9.984675e-01	0.001
R-HSA-418346	Platelet homeostasis	9.987784e-01	0.001
R-HSA-1483257	Phospholipid metabolism	9.989256e-01	0.000
R-HSA-9018678	Biosynthesis of specialized proresolving mediators (SPMs)	9.989307e-01	0.000
R-HSA-166658	Complement cascade	9.990355e-01	0.000
R-HSA-2187338	Visual phototransduction	9.991302e-01	0.000
R-HSA-3781865	Diseases of glycosylation	9.992411e-01	0.000
R-HSA-375276	Peptide ligand-binding receptors	9.993109e-01	0.000
R-HSA-9748784	Drug ADME	9.993246e-01	0.000
R-HSA-2142753	Arachidonate metabolism	9.993286e-01	0.000
R-HSA-2980736	Peptide hormone metabolism	9.994183e-01	0.000
R-HSA-382551	Transport of small molecules	9.994311e-01	0.000
R-HSA-9635486	Infection with Mycobacterium tuberculosis	9.995371e-01	0.000
R-HSA-9717207	Sensory perception of sweet, bitter, and umami (glutamate) taste	9.995871e-01	0.000
R-HSA-8956319	Nucleotide catabolism	9.997232e-01	0.000
R-HSA-418555	G alpha (s) signalling events	9.997634e-01	0.000
R-HSA-9717189	Sensory perception of taste	9.997668e-01	0.000
R-HSA-1474228	Degradation of the extracellular matrix	9.997798e-01	0.000
R-HSA-418594	G alpha (i) signalling events	9.998902e-01	0.000
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	9.999208e-01	0.000
R-HSA-9824439	Bacterial Infection Pathways	9.999313e-01	0.000
R-HSA-196854	Metabolism of vitamins and cofactors	9.999381e-01	0.000
R-HSA-156580	Phase II - Conjugation of compounds	9.999520e-01	0.000
R-HSA-1483206	Glycerophospholipid biosynthesis	9.999564e-01	0.000
R-HSA-6805567	Keratinization	9.999647e-01	0.000
R-HSA-211897	Cytochrome P450 - arranged by substrate type	9.999735e-01	0.000
R-HSA-9664433	Leishmania parasite growth and survival	9.999823e-01	0.000
R-HSA-9662851	Anti-inflammatory response favouring Leishmania parasite infection	9.999823e-01	0.000
R-HSA-388396	GPCR downstream signalling	9.999837e-01	0.000
R-HSA-425407	SLC-mediated transmembrane transport	9.999859e-01	0.000
R-HSA-372790	Signaling by GPCR	9.999978e-01	0.000
R-HSA-211945	Phase I - Functionalization of compounds	9.999993e-01	0.000
R-HSA-8957322	Metabolism of steroids	9.999994e-01	0.000
R-HSA-202733	Cell surface interactions at the vascular wall	9.999996e-01	0.000
R-HSA-8978868	Fatty acid metabolism	9.999996e-01	0.000
R-HSA-5668914	Diseases of metabolism	1.000000e+00	0.000
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	1.000000e+00	0.000
R-HSA-211859	Biological oxidations	1.000000e+00	0.000
R-HSA-500792	GPCR ligand binding	1.000000e+00	0.000
R-HSA-1430728	Metabolism	1.000000e+00	-0.000
R-HSA-556833	Metabolism of lipids	1.000000e+00	-0.000
R-HSA-9709957	Sensory Perception	1.000000e+00	-0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
GAK	0.915	0.086	1	0.828
VRK2	0.902	-0.155	1	0.859
PKR	0.902	-0.008	1	0.799
JNK2	0.900	0.555	1	0.849
TAK1	0.898	-0.148	1	0.772
JNK3	0.898	0.532	1	0.871
GCK	0.897	-0.029	1	0.769
VRK1	0.897	-0.192	2	0.897
LRRK2	0.896	-0.152	2	0.893
TNIK	0.895	-0.015	3	0.892
MINK	0.894	-0.092	1	0.749
EEF2K	0.894	-0.014	3	0.872
NLK	0.893	0.454	1	0.935
P38A	0.893	0.487	1	0.897
TTK	0.893	-0.007	-2	0.888
BMPR2	0.892	-0.150	-2	0.944
P38B	0.892	0.514	1	0.858
NIK	0.892	-0.048	-3	0.921
MEK1	0.892	-0.202	2	0.882
MST1	0.891	-0.115	1	0.750
NEK1	0.891	-0.175	1	0.751
TAO2	0.891	-0.093	2	0.905
BRAF	0.891	-0.144	-4	0.865
ASK1	0.891	-0.220	1	0.730
BIKE	0.890	0.026	1	0.718
MST2	0.890	-0.116	1	0.769
MEKK2	0.890	-0.123	2	0.853
ALK4	0.890	0.034	-2	0.895
DAPK2	0.889	-0.047	-3	0.903
KHS1	0.889	-0.045	1	0.741
PRP4	0.889	0.303	-3	0.815
MOS	0.888	0.130	1	0.854
MAP3K15	0.888	-0.145	1	0.740
MEK5	0.888	-0.286	2	0.870
HGK	0.888	-0.087	3	0.887
MST3	0.888	0.026	2	0.885
KHS2	0.888	0.007	1	0.756
TAO3	0.888	-0.031	1	0.774
NEK5	0.888	-0.148	1	0.776
PDK1	0.887	-0.157	1	0.766
ALPHAK3	0.886	-0.080	-1	0.792
CAMLCK	0.886	-0.032	-2	0.879
PRPK	0.886	-0.101	-1	0.878
HPK1	0.886	-0.072	1	0.752
LKB1	0.885	-0.148	-3	0.881
ANKRD3	0.883	-0.157	1	0.812
CDKL1	0.883	0.121	-3	0.836
P38G	0.883	0.528	1	0.797
DLK	0.883	-0.189	1	0.803
ICK	0.883	0.210	-3	0.874
OSR1	0.882	-0.107	2	0.844
MPSK1	0.882	0.029	1	0.770
MEKK6	0.882	-0.178	1	0.767
PASK	0.882	0.021	-3	0.896
CAMKK2	0.882	-0.213	-2	0.807
CAMK1B	0.882	-0.006	-3	0.897
ALK2	0.882	0.048	-2	0.878
NEK11	0.882	-0.186	1	0.767
LATS1	0.882	0.067	-3	0.894
MYO3A	0.882	-0.116	1	0.741
MYO3B	0.881	-0.102	2	0.868
CAMKK1	0.881	-0.248	-2	0.815
ERK2	0.880	0.465	1	0.873
AAK1	0.880	0.079	1	0.630
MEKK3	0.880	-0.145	1	0.771
NEK4	0.880	-0.207	1	0.741
NEK8	0.880	-0.210	2	0.870
ERK5	0.880	0.300	1	0.895
MEKK1	0.880	-0.219	1	0.775
PBK	0.880	-0.030	1	0.756
TGFBR1	0.880	0.075	-2	0.868
YSK1	0.879	-0.139	2	0.855
BMPR1B	0.878	0.152	1	0.780
YSK4	0.878	-0.150	1	0.738
P38D	0.877	0.523	1	0.802
CDK1	0.877	0.539	1	0.857
DMPK1	0.877	0.050	-3	0.791
HIPK1	0.877	0.432	1	0.891
ZAK	0.876	-0.168	1	0.754
CDK5	0.876	0.502	1	0.891
ATR	0.876	-0.087	1	0.785
CLK3	0.875	0.476	1	0.932
ERK1	0.875	0.494	1	0.850
JNK1	0.875	0.463	1	0.840
SMMLCK	0.875	-0.059	-3	0.851
STLK3	0.874	-0.305	1	0.714
MEK2	0.874	-0.379	2	0.848
ACVR2B	0.874	0.044	-2	0.874
ACVR2A	0.873	0.034	-2	0.861
DAPK3	0.873	-0.034	-3	0.835
SKMLCK	0.871	0.018	-2	0.884
RAF1	0.870	-0.160	1	0.799
LOK	0.870	-0.119	-2	0.810
COT	0.870	0.177	2	0.937
CDK14	0.870	0.486	1	0.862
ROCK2	0.869	0.003	-3	0.820
DYRK2	0.869	0.448	1	0.879
MLK2	0.869	-0.180	2	0.867
MAK	0.869	0.344	-2	0.753
PLK1	0.868	-0.049	-2	0.879
GRK7	0.868	0.115	1	0.757
PERK	0.868	-0.194	-2	0.905
CAMK2G	0.867	-0.046	2	0.865
MLK1	0.866	-0.091	2	0.869
GRK6	0.866	-0.016	1	0.808
HRI	0.866	-0.216	-2	0.912
BMPR1A	0.866	0.094	1	0.760
CDK3	0.865	0.523	1	0.814
CDK6	0.865	0.448	1	0.847
HIPK3	0.865	0.376	1	0.879
CDK2	0.864	0.401	1	0.894
CHAK2	0.864	-0.014	-1	0.873
TAO1	0.864	-0.146	1	0.696
CDK16	0.864	0.524	1	0.809
CDK17	0.864	0.510	1	0.799
NEK9	0.864	-0.207	2	0.884
GRK5	0.863	-0.135	-3	0.906
CDKL5	0.863	0.147	-3	0.825
CDK4	0.862	0.446	1	0.837
DYRK1A	0.862	0.342	1	0.906
MOK	0.862	0.288	1	0.863
PKN3	0.862	-0.014	-3	0.864
PDHK4	0.862	-0.335	1	0.830
WNK1	0.862	-0.021	-2	0.907
PIM1	0.861	0.092	-3	0.817
TSSK2	0.861	-0.020	-5	0.877
MASTL	0.861	-0.334	-2	0.872
DAPK1	0.861	-0.041	-3	0.816
WNK4	0.861	-0.169	-2	0.902
CDK18	0.861	0.519	1	0.836
HASPIN	0.861	-0.003	-1	0.705
DSTYK	0.860	-0.013	2	0.935
ERK7	0.860	0.164	2	0.582
SLK	0.860	-0.119	-2	0.760
IRAK4	0.860	-0.130	1	0.743
CLK4	0.860	0.264	-3	0.795
TLK2	0.860	-0.167	1	0.734
DYRK1B	0.859	0.423	1	0.860
PKCD	0.859	0.050	2	0.856
PIM3	0.859	0.052	-3	0.875
PINK1	0.858	-0.078	1	0.857
MTOR	0.858	0.053	1	0.825
RIPK3	0.858	-0.099	3	0.791
NUAK2	0.857	0.040	-3	0.875
MST4	0.857	0.054	2	0.900
AMPKA1	0.857	-0.026	-3	0.890
RIPK1	0.857	-0.273	1	0.760
BUB1	0.857	0.061	-5	0.820
NEK2	0.857	-0.177	2	0.856
TLK1	0.857	-0.198	-2	0.897
CDK13	0.857	0.446	1	0.865
PDHK1	0.857	-0.320	1	0.812
CDC7	0.856	-0.020	1	0.816
CDK8	0.856	0.463	1	0.877
MLK3	0.856	-0.013	2	0.805
CDK7	0.854	0.446	1	0.885
PKN2	0.854	-0.012	-3	0.876
GSK3A	0.854	0.180	4	0.520
MLK4	0.854	-0.094	2	0.778
GRK2	0.853	-0.037	-2	0.785
CDK12	0.853	0.442	1	0.847
HIPK2	0.853	0.472	1	0.827
DYRK4	0.853	0.462	1	0.847
CHK1	0.853	-0.070	-3	0.856
HIPK4	0.853	0.271	1	0.883
ROCK1	0.852	-0.032	-3	0.782
SRPK1	0.852	0.256	-3	0.782
DCAMKL1	0.852	-0.062	-3	0.818
DRAK1	0.852	-0.101	1	0.732
PIM2	0.852	0.023	-3	0.773
HUNK	0.852	-0.159	2	0.860
NEK3	0.852	-0.252	1	0.727
DYRK3	0.852	0.306	1	0.878
CDK10	0.852	0.472	1	0.853
GSK3B	0.851	0.062	4	0.511
TGFBR2	0.851	-0.033	-2	0.863
P70S6KB	0.851	-0.020	-3	0.827
DNAPK	0.851	-0.061	1	0.654
SRPK3	0.851	0.160	-3	0.755
CLK1	0.851	0.303	-3	0.772
PLK3	0.850	-0.108	2	0.821
NEK7	0.850	-0.158	-3	0.886
TSSK1	0.850	-0.009	-3	0.907
CDK9	0.850	0.415	1	0.869
GRK1	0.849	0.138	-2	0.852
MRCKA	0.849	-0.020	-3	0.785
DCAMKL2	0.849	-0.082	-3	0.840
CHAK1	0.848	-0.180	2	0.815
MARK4	0.848	-0.063	4	0.863
MRCKB	0.848	-0.011	-3	0.768
TBK1	0.848	-0.160	1	0.701
ULK2	0.848	-0.206	2	0.839
MYLK4	0.846	-0.034	-2	0.786
CAMK2D	0.846	-0.079	-3	0.877
IRE1	0.846	-0.100	1	0.745
CRIK	0.846	-0.020	-3	0.732
NEK6	0.846	-0.042	-2	0.924
ATM	0.845	-0.092	1	0.710
WNK3	0.844	-0.306	1	0.769
SGK3	0.844	-0.013	-3	0.792
AMPKA2	0.844	-0.030	-3	0.856
SMG1	0.844	-0.134	1	0.727
CDK19	0.843	0.462	1	0.852
IRE2	0.843	-0.107	2	0.810
PKCA	0.843	0.012	2	0.794
PKCZ	0.842	-0.048	2	0.835
IRAK1	0.842	-0.331	-1	0.768
PDHK3_TYR	0.841	0.254	4	0.942
RSK2	0.841	0.048	-3	0.800
PKCH	0.841	-0.041	2	0.786
IKKE	0.841	-0.181	1	0.697
AKT2	0.841	0.018	-3	0.713
CAMK2B	0.840	0.018	2	0.832
TTBK2	0.840	-0.224	2	0.755
P90RSK	0.839	0.002	-3	0.803
IKKB	0.839	-0.111	-2	0.818
PKCB	0.838	0.024	2	0.801
MELK	0.838	-0.091	-3	0.837
PAK2	0.838	-0.148	-2	0.780
CAMK4	0.838	-0.157	-3	0.856
GRK4	0.837	-0.143	-2	0.898
CLK2	0.837	0.339	-3	0.778
PAK1	0.837	-0.076	-2	0.793
NDR1	0.836	-0.049	-3	0.872
PLK2	0.835	-0.062	-3	0.813
CHK2	0.835	-0.042	-3	0.655
MAPKAPK3	0.835	-0.053	-3	0.808
PKCG	0.835	-0.008	2	0.806
QIK	0.835	-0.145	-3	0.871
CAMK2A	0.835	0.011	2	0.846
RIPK2	0.835	-0.352	1	0.705
SGK1	0.834	0.015	-3	0.629
CAMK1D	0.834	-0.051	-3	0.712
CAMK1G	0.833	-0.065	-3	0.791
PRKD3	0.833	-0.012	-3	0.772
PKCE	0.832	0.026	2	0.789
PDHK4_TYR	0.832	0.103	2	0.923
PRKD1	0.832	0.036	-3	0.859
NIM1	0.832	-0.140	3	0.815
SSTK	0.832	-0.060	4	0.831
MARK2	0.832	-0.083	4	0.754
IKKA	0.832	-0.034	-2	0.811
ULK1	0.832	-0.232	-3	0.860
PAK3	0.831	-0.136	-2	0.793
TESK1_TYR	0.831	-0.022	3	0.915
AURB	0.831	-0.026	-2	0.657
PLK4	0.831	-0.158	2	0.676
KIS	0.831	0.504	1	0.896
BMPR2_TYR	0.831	0.077	-1	0.888
MAP2K6_TYR	0.830	0.028	-1	0.889
AKT1	0.830	-0.003	-3	0.733
MAP2K4_TYR	0.830	-0.058	-1	0.885
PKMYT1_TYR	0.830	0.015	3	0.888
STK33	0.830	-0.215	2	0.674
SRPK2	0.830	0.198	-3	0.699
PKCI	0.829	-0.056	2	0.803
QSK	0.829	-0.047	4	0.835
PKACG	0.828	-0.034	-2	0.759
GCN2	0.828	-0.249	2	0.841
RSK4	0.827	0.036	-3	0.773
MAP2K7_TYR	0.827	-0.213	2	0.904
PDHK1_TYR	0.827	-0.036	-1	0.903
MARK1	0.826	-0.119	4	0.818
SBK	0.826	0.046	-3	0.586
MNK1	0.826	-0.021	-2	0.821
MSK1	0.826	-0.027	-3	0.777
CK1D	0.826	0.047	-3	0.555
MARK3	0.826	-0.051	4	0.795
RSK3	0.826	-0.030	-3	0.793
PKG2	0.826	-0.009	-2	0.683
PKCT	0.826	-0.065	2	0.795
GRK3	0.826	-0.030	-2	0.740
PRKD2	0.825	0.055	-3	0.804
NDR2	0.825	0.008	-3	0.885
BCKDK	0.825	-0.234	-1	0.811
LATS2	0.824	-0.040	-5	0.784
LIMK2_TYR	0.824	0.015	-3	0.932
PINK1_TYR	0.824	-0.195	1	0.818
NUAK1	0.824	-0.044	-3	0.822
MNK2	0.824	-0.036	-2	0.807
MSK2	0.823	-0.077	-3	0.773
EPHA6	0.822	0.014	-1	0.889
AURA	0.821	-0.054	-2	0.627
CK2A2	0.820	0.095	1	0.704
EPHB4	0.820	-0.029	-1	0.867
CAMK1A	0.819	-0.048	-3	0.681
MAPKAPK2	0.819	0.002	-3	0.762
AURC	0.819	0.023	-2	0.658
TXK	0.818	0.094	1	0.813
CK1A2	0.818	0.025	-3	0.552
PHKG1	0.818	-0.105	-3	0.863
LIMK1_TYR	0.817	-0.179	2	0.902
SIK	0.817	-0.068	-3	0.795
TTBK1	0.817	-0.217	2	0.680
RET	0.817	-0.197	1	0.772
P70S6K	0.816	-0.089	-3	0.731
PKACB	0.816	0.023	-2	0.678
MST1R	0.815	-0.177	3	0.848
TYK2	0.815	-0.236	1	0.765
TYRO3	0.815	-0.167	3	0.834
YES1	0.815	-0.042	-1	0.872
CK1E	0.815	0.035	-3	0.603
ROS1	0.814	-0.154	3	0.807
JAK2	0.814	-0.177	1	0.774
CSF1R	0.814	-0.121	3	0.830
DDR1	0.814	-0.183	4	0.869
CK2A1	0.813	0.083	1	0.684
ABL2	0.813	-0.062	-1	0.830
FGR	0.813	-0.117	1	0.813
EPHA4	0.812	-0.041	2	0.822
FAM20C	0.812	0.089	2	0.654
HCK	0.811	-0.058	-1	0.858
FER	0.811	-0.175	1	0.827
LCK	0.811	0.022	-1	0.864
PKN1	0.811	-0.063	-3	0.748
INSRR	0.810	-0.114	3	0.786
BLK	0.810	0.058	-1	0.868
SRMS	0.810	-0.092	1	0.809
EPHB1	0.810	-0.087	1	0.806
TNK2	0.809	-0.080	3	0.806
YANK3	0.809	-0.089	2	0.452
JAK3	0.809	-0.166	1	0.755
ABL1	0.809	-0.088	-1	0.823
SNRK	0.809	-0.306	2	0.725
ITK	0.808	-0.068	-1	0.826
EPHB3	0.808	-0.092	-1	0.855
EPHB2	0.808	-0.065	-1	0.849
AKT3	0.807	-0.000	-3	0.648
BRSK2	0.807	-0.155	-3	0.850
MAPKAPK5	0.807	-0.182	-3	0.740
KIT	0.807	-0.149	3	0.834
BRSK1	0.806	-0.108	-3	0.824
FGFR2	0.806	-0.168	3	0.828
PKACA	0.806	-0.007	-2	0.623
PAK6	0.806	-0.037	-2	0.711
KDR	0.805	-0.122	3	0.796
FYN	0.805	0.036	-1	0.847
TNNI3K_TYR	0.804	-0.052	1	0.795
PDGFRB	0.804	-0.236	3	0.845
BMX	0.804	-0.062	-1	0.759
JAK1	0.803	-0.105	1	0.715
TEK	0.803	-0.152	3	0.776
PHKG2	0.803	-0.098	-3	0.830
FLT3	0.803	-0.211	3	0.829
TEC	0.802	-0.088	-1	0.773
MET	0.802	-0.122	3	0.823
MERTK	0.802	-0.132	3	0.809
FGFR1	0.802	-0.187	3	0.803
AXL	0.801	-0.190	3	0.810
TNK1	0.801	-0.160	3	0.812
EPHA7	0.801	-0.080	2	0.829
WEE1_TYR	0.800	-0.130	-1	0.773
NEK10_TYR	0.799	-0.211	1	0.648
BTK	0.799	-0.232	-1	0.790
YANK2	0.799	-0.116	2	0.471
FLT1	0.798	-0.140	-1	0.842
PRKX	0.798	0.074	-3	0.710
EPHA3	0.798	-0.154	2	0.797
PTK2B	0.797	-0.048	-1	0.811
LYN	0.797	-0.088	3	0.758
DDR2	0.797	-0.031	3	0.778
ALK	0.797	-0.201	3	0.763
FRK	0.797	-0.121	-1	0.866
ERBB2	0.796	-0.210	1	0.737
LTK	0.796	-0.197	3	0.785
PDGFRA	0.796	-0.323	3	0.845
FGFR3	0.795	-0.175	3	0.803
NTRK1	0.795	-0.284	-1	0.830
PTK2	0.793	0.040	-1	0.813
SRC	0.793	-0.075	-1	0.842
EPHA1	0.793	-0.178	3	0.800
EPHA5	0.793	-0.101	2	0.808
INSR	0.792	-0.220	3	0.762
EPHA8	0.792	-0.091	-1	0.842
PTK6	0.791	-0.323	-1	0.753
NTRK2	0.791	-0.288	3	0.797
FLT4	0.791	-0.252	3	0.791
NTRK3	0.790	-0.207	-1	0.787
EGFR	0.789	-0.119	1	0.656
MATK	0.789	-0.167	-1	0.758
SYK	0.789	0.009	-1	0.799
PAK5	0.788	-0.112	-2	0.639
CSK	0.785	-0.215	2	0.828
FGFR4	0.784	-0.152	-1	0.787
EPHA2	0.782	-0.106	-1	0.800
CK1G1	0.781	-0.037	-3	0.600
ERBB4	0.779	-0.078	1	0.673
PAK4	0.778	-0.100	-2	0.644
IGF1R	0.778	-0.205	3	0.703
MUSK	0.777	-0.208	1	0.635
PKG1	0.774	-0.090	-2	0.595
CK1G3	0.771	-0.035	-3	0.416
FES	0.767	-0.186	-1	0.737
ZAP70	0.763	-0.067	-1	0.726
CK1G2	0.751	-0.030	-3	0.515
CK1A	0.748	-0.015	-3	0.462