Motif 108 (n=75)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
C9JH25	PRRT4	S821	ochoa	Proline-rich transmembrane protein 4	None
O14686	KMT2D	S2592	ochoa	Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)	Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269\|PubMed:16603732, ECO:0000269\|PubMed:17500065, ECO:0000269\|PubMed:25561738}.
O60315	ZEB2	S731	ochoa	Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)	Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269\|PubMed:16061479, ECO:0000269\|PubMed:20516212}.
O60315	ZEB2	S738	ochoa	Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)	Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269\|PubMed:16061479, ECO:0000269\|PubMed:20516212}.
O76039	CDKL5	S476	ochoa	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9)	Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269\|PubMed:15917271, ECO:0000269\|PubMed:16935860, ECO:0000269\|PubMed:29420175}.
O94989	ARHGEF15	S90	ochoa	Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)	Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269\|PubMed:12775584}.
O95429	BAG4	S286	ochoa	BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains)	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269\|PubMed:24270810}.
O95644	NFATC1	S169	ochoa	Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)	Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). {ECO:0000250\|UniProtKB:O88942, ECO:0000269\|PubMed:10358178}.
P20393	NR1D1	S55	psp	Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)	Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity). {ECO:0000250\|UniProtKB:Q3UV55, ECO:0000269\|PubMed:12021280, ECO:0000269\|PubMed:15761026, ECO:0000269\|PubMed:16968709, ECO:0000269\|PubMed:18006707, ECO:0000269\|PubMed:19710360, ECO:0000269\|PubMed:1971514, ECO:0000269\|PubMed:21479263, ECO:0000269\|PubMed:22184247, ECO:0000269\|PubMed:23398316, ECO:0000269\|PubMed:2539258}.
P24928	POLR2A	S1616	psp	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P26651	ZFP36	S197	psp	mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250\|UniProtKB:P22893, ECO:0000269\|PubMed:10330172, ECO:0000269\|PubMed:10751406, ECO:0000269\|PubMed:11279239, ECO:0000269\|PubMed:11719186, ECO:0000269\|PubMed:12115244, ECO:0000269\|PubMed:12748283, ECO:0000269\|PubMed:15187101, ECO:0000269\|PubMed:15634918, ECO:0000269\|PubMed:15687258, ECO:0000269\|PubMed:15766526, ECO:0000269\|PubMed:16364915, ECO:0000269\|PubMed:16702957, ECO:0000269\|PubMed:17030620, ECO:0000269\|PubMed:17369404, ECO:0000269\|PubMed:18367721, ECO:0000269\|PubMed:19188452, ECO:0000269\|PubMed:20221403, ECO:0000269\|PubMed:20702587, ECO:0000269\|PubMed:21775632, ECO:0000269\|PubMed:23644599, ECO:0000269\|PubMed:25815583, ECO:0000269\|PubMed:26926077, ECO:0000269\|PubMed:27182009, ECO:0000269\|PubMed:27193233, ECO:0000269\|PubMed:31439631, ECO:0000269\|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269\|PubMed:14679154}.
P26651	ZFP36	S218	psp	mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:23644599, PubMed:25815583, PubMed:27193233, PubMed:31439631, PubMed:9703499). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:16702957, PubMed:17030620, PubMed:19188452, PubMed:20221403, PubMed:20702587, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250\|UniProtKB:P22893, ECO:0000269\|PubMed:10330172, ECO:0000269\|PubMed:10751406, ECO:0000269\|PubMed:11279239, ECO:0000269\|PubMed:11719186, ECO:0000269\|PubMed:12115244, ECO:0000269\|PubMed:12748283, ECO:0000269\|PubMed:15187101, ECO:0000269\|PubMed:15634918, ECO:0000269\|PubMed:15687258, ECO:0000269\|PubMed:15766526, ECO:0000269\|PubMed:16364915, ECO:0000269\|PubMed:16702957, ECO:0000269\|PubMed:17030620, ECO:0000269\|PubMed:17369404, ECO:0000269\|PubMed:18367721, ECO:0000269\|PubMed:19188452, ECO:0000269\|PubMed:20221403, ECO:0000269\|PubMed:20702587, ECO:0000269\|PubMed:21775632, ECO:0000269\|PubMed:23644599, ECO:0000269\|PubMed:25815583, ECO:0000269\|PubMed:26926077, ECO:0000269\|PubMed:27182009, ECO:0000269\|PubMed:27193233, ECO:0000269\|PubMed:31439631, ECO:0000269\|PubMed:9703499}.; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. {ECO:0000269\|PubMed:14679154}.
P78527	PRKDC	S2041	psp	DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460)	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250\|UniProtKB:P97313, ECO:0000269\|PubMed:10026262, ECO:0000269\|PubMed:10467406, ECO:0000269\|PubMed:11889123, ECO:0000269\|PubMed:11955432, ECO:0000269\|PubMed:12509254, ECO:0000269\|PubMed:12649176, ECO:0000269\|PubMed:14599745, ECO:0000269\|PubMed:14612514, ECO:0000269\|PubMed:14627815, ECO:0000269\|PubMed:14704337, ECO:0000269\|PubMed:14734805, ECO:0000269\|PubMed:15177042, ECO:0000269\|PubMed:15262962, ECO:0000269\|PubMed:15574326, ECO:0000269\|PubMed:1597196, ECO:0000269\|PubMed:16046194, ECO:0000269\|PubMed:16397295, ECO:0000269\|PubMed:18644470, ECO:0000269\|PubMed:2247066, ECO:0000269\|PubMed:2507541, ECO:0000269\|PubMed:26237645, ECO:0000269\|PubMed:26666690, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:29478807, ECO:0000269\|PubMed:30247612, ECO:0000269\|PubMed:32103174, ECO:0000269\|PubMed:33273464, ECO:0000269\|PubMed:33854234, ECO:0000269\|PubMed:34352203, ECO:0000269\|PubMed:35460603, ECO:0000269\|PubMed:8407951, ECO:0000269\|PubMed:8464713, ECO:0000269\|PubMed:9139719, ECO:0000269\|PubMed:9362500, ECO:0000269\|PubMed:9363941, ECO:0000269\|PubMed:9679063}.
P78559	MAP1A	S2259	ochoa	Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]	Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Q03164	KMT2A	S2121	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q12888	TP53BP1	S452	psp	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250\|UniProtKB:P70399, ECO:0000269\|PubMed:12364621, ECO:0000269\|PubMed:17190600, ECO:0000269\|PubMed:21144835, ECO:0000269\|PubMed:22553214, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:23345425, ECO:0000269\|PubMed:23727112, ECO:0000269\|PubMed:23760478, ECO:0000269\|PubMed:27153538, ECO:0000269\|PubMed:28241136, ECO:0000269\|PubMed:31135337, ECO:0000269\|PubMed:37696958}.
Q12955	ANK3	S3055	ochoa	Ankyrin-3 (ANK-3) (Ankyrin-G)	Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250\|UniProtKB:G5E8K5, ECO:0000250\|UniProtKB:O70511, ECO:0000269\|PubMed:23903368, ECO:0000269\|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305\|PubMed:17974005}.
Q13490	BIRC2	S140	ochoa	Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269\|PubMed:15665297, ECO:0000269\|PubMed:18082613, ECO:0000269\|PubMed:21145488, ECO:0000269\|PubMed:21653699, ECO:0000269\|PubMed:21931591, ECO:0000269\|PubMed:23453969}.
Q13796	SHROOM2	S1036	ochoa	Protein Shroom2 (Apical-like protein) (Protein APXL)	May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q14938	NFIX	T463	ochoa	Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein)	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Q2KHR2	RFX7	S1290	ochoa	DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2)	Transcription factor (PubMed:29967452). Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (PubMed:29967452, PubMed:34197623). Plays a role in natural killer (NK) cell maintenance and immunity (PubMed:29967452). May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity). {ECO:0000250\|UniProtKB:A0A1L8H0H2, ECO:0000269\|PubMed:29967452, ECO:0000269\|PubMed:34197623}.
Q2M1Z3	ARHGAP31	S457	ochoa	Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)	Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269\|PubMed:12192056, ECO:0000269\|PubMed:16519628}.
Q4LE39	ARID4B	S1029	ochoa	AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)	Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250\|UniProtKB:A2CG63, ECO:0000269\|PubMed:12724404}.
Q5SVZ6	ZMYM1	S387	ochoa	Zinc finger MYM-type protein 1	None
Q5SWA1	PPP1R15B	S203	ochoa	Protein phosphatase 1 regulatory subunit 15B	Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000269\|PubMed:26159176, ECO:0000269\|PubMed:26307080}.
Q5VT52	RPRD2	S614	ochoa	Regulation of nuclear pre-mRNA domain-containing protein 2	None
Q684P5	RAP1GAP2	S668	ochoa	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4)	GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. {ECO:0000269\|PubMed:15632203}.
Q6IE81	JADE1	S290	ochoa	Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17)	Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269\|PubMed:15502158, ECO:0000269\|PubMed:16046545, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:19187766, ECO:0000269\|PubMed:20129055, ECO:0000269\|PubMed:22654112, ECO:0000269\|PubMed:24065767}.
Q6P2H3	CEP85	S102	ochoa	Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21)	Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269\|PubMed:26220856, ECO:0000269\|PubMed:29712910, ECO:0000269\|PubMed:32107292}.
Q6V0I7	FAT4	S4699	ochoa	Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)	Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}.
Q6ZS17	RIPOR1	S565	ochoa	Rho family-interacting cell polarization regulator 1	Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). {ECO:0000269\|PubMed:27807006}.
Q6ZV73	FGD6	S228	ochoa	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)	May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Q70EL1	USP54	S671	ochoa	Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54)	Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269\|PubMed:36590171, ECO:0000269\|PubMed:39587316}.
Q7Z460	CLASP1	S1106	ochoa	CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1)	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269\|PubMed:11290329, ECO:0000269\|PubMed:12837247, ECO:0000269\|PubMed:15631994, ECO:0000269\|PubMed:16866869, ECO:0000269\|PubMed:16914514, ECO:0000269\|PubMed:17543864}.
Q7Z7G8	VPS13B	S1263	ochoa	Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B)	Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250\|UniProtKB:Q07878, ECO:0000250\|UniProtKB:Q80TY5, ECO:0000269\|PubMed:21865173, ECO:0000269\|PubMed:24334764, ECO:0000269\|PubMed:26358774, ECO:0000269\|PubMed:30962439, ECO:0000269\|PubMed:32375900, ECO:0000269\|PubMed:32560273, ECO:0000305\|PubMed:25492866, ECO:0000305\|PubMed:32560273}.
Q86T82	USP37	S628	ochoa\|psp	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37)	Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed:26299517, PubMed:27296872, PubMed:31911859, PubMed:34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed:34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed:34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed:34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed:31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed:26299517). {ECO:0000269\|PubMed:21596315, ECO:0000269\|PubMed:26299517, ECO:0000269\|PubMed:27296872, ECO:0000269\|PubMed:31911859, ECO:0000269\|PubMed:34509474, ECO:0000269\|PubMed:34606619}.
Q86VQ1	GLCCI1	S145	ochoa	Glucocorticoid-induced transcript 1 protein	None
Q86W56	PARG	S323	ochoa	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143)	Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:15450800, PubMed:21892188, PubMed:23102699, PubMed:23474714, PubMed:33186521, PubMed:34019811, PubMed:34321462). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers (PubMed:23102699, PubMed:23481255). It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated (PubMed:21892188, PubMed:23474714, PubMed:33186521). Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG (PubMed:23102699, PubMed:34019811). Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress (PubMed:24906880). Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond (PubMed:33186521). Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269\|PubMed:15450800, ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:23102699, ECO:0000269\|PubMed:23474714, ECO:0000269\|PubMed:23481255, ECO:0000269\|PubMed:24906880, ECO:0000269\|PubMed:27257257, ECO:0000269\|PubMed:33186521, ECO:0000269\|PubMed:34019811, ECO:0000269\|PubMed:34321462}.
Q8N568	DCLK2	S341	ochoa	Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)	Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). {ECO:0000250}.
Q8NG08	HELB	S967	ochoa\|psp	DNA helicase B (hDHB) (EC 3.6.4.12)	5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269\|PubMed:12181327, ECO:0000269\|PubMed:22194613, ECO:0000269\|PubMed:25617833, ECO:0000269\|PubMed:26774285}.
Q8WYQ5	DGCR8	S92	ochoa	Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)	Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). Also plays a role in DNA repair by promoting the recruitment of RNF168 to RNF8 and MDC1 at DNA double-strand breaks and subsequently the clearance of DNA breaks (PubMed:34188037). {ECO:0000250\|UniProtKB:Q9EQM6, ECO:0000269\|PubMed:15531877, ECO:0000269\|PubMed:15574589, ECO:0000269\|PubMed:15589161, ECO:0000269\|PubMed:16751099, ECO:0000269\|PubMed:16906129, ECO:0000269\|PubMed:16963499, ECO:0000269\|PubMed:17159994, ECO:0000269\|PubMed:25799998, ECO:0000269\|PubMed:26027739, ECO:0000269\|PubMed:26748718}.
Q96GV9	MACIR	S25	ochoa	Macrophage immunometabolism regulator	Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962). {ECO:0000269\|PubMed:22085962, ECO:0000269\|PubMed:30659109}.
Q96JM2	ZNF462	S295	ochoa	Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP)	Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250\|UniProtKB:B1AWL2, ECO:0000269\|PubMed:20219459, ECO:0000269\|PubMed:21570965}.
Q96SK2	TMEM209	S198	ochoa	Transmembrane protein 209	Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC. {ECO:0000269\|PubMed:22719065}.
Q9BT25	HAUS8	T382	ochoa	HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48)	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269\|PubMed:18362163, ECO:0000269\|PubMed:19369198, ECO:0000269\|PubMed:19427217}.
Q9BUJ2	HNRNPUL1	S751	ochoa	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5)	Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Also plays a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269\|PubMed:12489984, ECO:0000269\|PubMed:9733834}.
Q9BZE9	ASPSCR1	S275	ochoa	Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9)	Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. {ECO:0000250, ECO:0000269\|PubMed:23349634}.
Q9H1B7	IRF2BPL	S659	ochoa	Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)	Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250\|UniProtKB:Q5EIC4, ECO:0000269\|PubMed:29374064, ECO:0000305\|PubMed:17334524, ECO:0000305\|PubMed:29374064, ECO:0000305\|PubMed:30057031}.
Q9H706	GAREM1	S700	ochoa	GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)	[Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269\|PubMed:19509291}.
Q9H9J4	USP42	S494	ochoa	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.4.19.12) (Deubiquitinating enzyme 42) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42)	Deubiquitinating enzyme which may play an important role during spermatogenesis. {ECO:0000250}.
Q9HBL0	TNS1	S1307	psp	Tensin-1 (EC 3.1.3.-)	May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269\|PubMed:19826001, ECO:0000269\|PubMed:21768292, ECO:0000269\|PubMed:26427649, ECO:0000269\|PubMed:28005397, ECO:0000305}.
Q9HCH5	SYTL2	S395	ochoa	Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4)	Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269\|PubMed:17182843, ECO:0000269\|PubMed:18266782, ECO:0000269\|PubMed:18812475}.
Q9NQW6	ANLN	S927	ochoa	Anillin	Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269\|PubMed:10931866, ECO:0000269\|PubMed:12479805, ECO:0000269\|PubMed:15496454, ECO:0000269\|PubMed:16040610, ECO:0000269\|PubMed:16357138, ECO:0000269\|PubMed:23870127, ECO:0000269\|PubMed:24676636}.
Q9NRA0	SPHK2	S484	ochoa	Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91)	Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides (PubMed:12954646, PubMed:19168031). In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis (PubMed:16118219). In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulation via PHB2 of complex IV assembly and respiration (PubMed:20959514). In nucleus, plays a role in epigenetic regulation of gene expression. Interacts with HDAC1 and HDAC2 and, through SPP production, inhibits their enzymatic activity, preventing the removal of acetyl groups from lysine residues with histones. Up-regulates acetylation of histone H3-K9, histone H4-K5 and histone H2B-K12 (PubMed:19729656). In nucleus, may have an inhibitory effect on DNA synthesis and cell cycle (PubMed:12954646, PubMed:16103110). In mast cells, is the main regulator of SPP production which mediates calcium influx, NF-kappa-B activation, cytokine production, such as TNF and IL6, and degranulation of mast cells (By similarity). In dopaminergic neurons, is involved in promoting mitochondrial functions regulating ATP and ROS levels (By similarity). Also involved in the regulation of glucose and lipid metabolism (By similarity). {ECO:0000250\|UniProtKB:Q9JIA7, ECO:0000269\|PubMed:12954646, ECO:0000269\|PubMed:16103110, ECO:0000269\|PubMed:16118219, ECO:0000269\|PubMed:19168031, ECO:0000269\|PubMed:19729656, ECO:0000269\|PubMed:20959514}.
Q9NSC2	SALL1	S583	ochoa	Sal-like protein 1 (Spalt-like transcription factor 1) (Zinc finger protein 794) (Zinc finger protein SALL1) (Zinc finger protein Spalt-1) (HSal1) (Sal-1)	Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development. {ECO:0000250\|UniProtKB:Q9ER74}.
Q9NYF3	FAM53C	S190	ochoa\|psp	Protein FAM53C	None
Q9UHB7	AFF4	S222	ochoa	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)	Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269\|PubMed:20159561, ECO:0000269\|PubMed:20471948, ECO:0000269\|PubMed:23251033}.
Q9UKN1	MUC12	S1194	ochoa	Mucin-12 (MUC-12) (Mucin-11) (MUC-11)	Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269\|PubMed:17058067}.
Q9ULI4	KIF26A	S1662	ochoa	Kinesin-like protein KIF26A	Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250\|UniProtKB:Q52KG5, ECO:0000269\|PubMed:36228617}.
Q9UNH5	CDC14A	S549	psp	Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A)	Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269\|PubMed:11901424, ECO:0000269\|PubMed:12134069, ECO:0000269\|PubMed:17488717, ECO:0000269\|PubMed:29293958, ECO:0000269\|PubMed:9367992}.
Q9Y2H9	MAST1	S43	ochoa	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase)	Microtubule-associated protein essential for correct brain development (PubMed:30449657). Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). {ECO:0000250\|UniProtKB:Q9R1L5, ECO:0000269\|PubMed:30449657}.
Q9Y4F4	TOGARAM1	S836	ochoa	TOG array regulator of axonemal microtubules protein 1 (Crescerin-1) (Protein FAM179B)	Involved in ciliogenesis (PubMed:32453716). It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (PubMed:32453716). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). {ECO:0000250\|UniProtKB:Q17423, ECO:0000250\|UniProtKB:Q6A070, ECO:0000269\|PubMed:32453716}.
Q9Y6Q9	NCOA3	S505	psp	Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Q99504	EYA3	S157	PSP	Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3)	Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250\|UniProtKB:P97480, ECO:0000269\|PubMed:19234442, ECO:0000269\|PubMed:19351884}.
P24928	POLR2A	S1623	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1644	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1651	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1665	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1672	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1693	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1714	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1721	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1735	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1763	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.
P24928	POLR2A	S1784	SIGNOR	DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)	Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity) (PubMed:23748380, PubMed:27193682, PubMed:28108474, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the second largest subunit POLR2B/RPB2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif, and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:8381534, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). Through its unique C-terminal domain (CTD, 52 heptapeptide tandem repeats) serves as a platform for assembly of factors that regulate transcription initiation, elongation and termination. CTD phosphorylation on Ser-5 mediates Pol II promoter escape, whereas phosphorylation on Ser-2 is required for Pol II pause release during transcription elongation and further pre-mRNA processing. Additionally, the regulation of gene expression levels depends on the balance between methylation and acetylation levels of the CTD-lysines. Initiation or early elongation steps of transcription of growth-factor-induced immediate early genes are regulated by the acetylation status of the CTD. Methylation and dimethylation have a repressive effect on target genes expression. Cooperates with mRNA splicing machinery in co-transcriptional 5'-end capping and co-transcriptional splicing of pre-mRNA (By similarity) (PubMed:24207025, PubMed:26124092). {ECO:0000250\|UniProtKB:G3MZY8, ECO:0000250\|UniProtKB:P08775, ECO:0000269\|PubMed:23748380, ECO:0000269\|PubMed:24207025, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27193682, ECO:0000269\|PubMed:28108474, ECO:0000269\|PubMed:30190596, ECO:0000269\|PubMed:8381534, ECO:0000269\|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269\|PubMed:23395899}.; FUNCTION: (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome. {ECO:0000269\|PubMed:18032511}.

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reactome_id	name	p	-log10_p
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	0.000342	3.466
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	0.001843	2.735
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL...	0.003554	2.449
R-HSA-9832991	Formation of the posterior neural plate	0.001610	2.793
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	0.002354	2.628
R-HSA-75893	TNF signaling	0.002487	2.604
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	0.002925	2.534
R-HSA-9823739	Formation of the anterior neural plate	0.002925	2.534
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	0.003554	2.449
R-HSA-5689880	Ub-specific processing proteases	0.001260	2.900
R-HSA-937041	IKK complex recruitment mediated by RIP1	0.004605	2.337
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.005376	2.270
R-HSA-73887	Death Receptor Signaling	0.005847	2.233
R-HSA-5688426	Deubiquitination	0.005838	2.234
R-HSA-9830674	Formation of the ureteric bud	0.006635	2.178
R-HSA-203927	MicroRNA (miRNA) biogenesis	0.007541	2.123
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	0.008500	2.071
R-HSA-9933387	RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	0.010035	1.998
R-HSA-5619507	Activation of HOX genes during differentiation	0.012712	1.896
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	0.012712	1.896
R-HSA-168638	NOD1/2 Signaling Pathway	0.012844	1.891
R-HSA-5675482	Regulation of necroptotic cell death	0.011684	1.932
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	0.013443	1.872
R-HSA-5213460	RIPK1-mediated regulated necrosis	0.015309	1.815
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.015309	1.815
R-HSA-3214841	PKMTs methylate histone lysines	0.017280	1.762
R-HSA-8853336	Signaling by plasma membrane FGFR1 fusions	0.020592	1.686
R-HSA-9944997	Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	0.020592	1.686
R-HSA-9944971	Loss of Function of KMT2D in Kabuki Syndrome	0.020592	1.686
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.023027	1.638
R-HSA-9909396	Circadian clock	0.024049	1.619
R-HSA-5357905	Regulation of TNFR1 signaling	0.021526	1.667
R-HSA-73894	DNA Repair	0.021120	1.675
R-HSA-3247509	Chromatin modifying enzymes	0.021620	1.665
R-HSA-112382	Formation of RNA Pol II elongation complex	0.026156	1.582
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.026964	1.569
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centr...	0.035578	1.449
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.035578	1.449
R-HSA-8854518	AURKA Activation by TPX2	0.038344	1.416
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	0.035207	1.453
R-HSA-9707616	Heme signaling	0.034674	1.460
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	0.040233	1.395
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.032018	1.495
R-HSA-428890	Role of ABL in ROBO-SLIT signaling	0.040766	1.390
R-HSA-5693606	DNA Double Strand Break Response	0.039284	1.406
R-HSA-5693532	DNA Double-Strand Break Repair	0.034697	1.460
R-HSA-4839726	Chromatin organization	0.025980	1.585
R-HSA-5218859	Regulated Necrosis	0.040233	1.395
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	0.036491	1.438
R-HSA-9830369	Kidney development	0.039284	1.406
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.045104	1.346
R-HSA-380287	Centrosome maturation	0.047111	1.327
R-HSA-2025928	Calcineurin activates NFAT	0.048720	1.312
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.046104	1.336
R-HSA-212165	Epigenetic regulation of gene expression	0.054858	1.261
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.056533	1.248
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	0.055456	1.256
R-HSA-9762293	Regulation of CDH11 gene transcription	0.048720	1.312
R-HSA-5687128	MAPK6/MAPK4 signaling	0.057618	1.239
R-HSA-1226099	Signaling by FGFR in disease	0.046104	1.336
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription	0.052673	1.278
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.076053	1.119
R-HSA-5083636	Defective GALNT12 causes CRCS1	0.079894	1.097
R-HSA-5083625	Defective GALNT3 causes HFTC	0.079894	1.097
R-HSA-5083632	Defective C1GALT1C1 causes TNPS	0.087528	1.058
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.095101	1.022
R-HSA-6803529	FGFR2 alternative splicing	0.110060	0.958
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	0.113762	0.944
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.113762	0.944
R-HSA-977068	Termination of O-glycan biosynthesis	0.113762	0.944
R-HSA-445095	Interaction between L1 and Ankyrins	0.128417	0.891
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.128417	0.891
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.128417	0.891
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.132044	0.879
R-HSA-167287	HIV elongation arrest and recovery	0.132044	0.879
R-HSA-113418	Formation of the Early Elongation Complex	0.132044	0.879
R-HSA-167290	Pausing and recovery of HIV elongation	0.132044	0.879
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.177856	0.750
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.062029	1.207
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	0.184689	0.734
R-HSA-167161	HIV Transcription Initiation	0.184689	0.734
R-HSA-75953	RNA Polymerase II Transcription Initiation	0.184689	0.734
R-HSA-73776	RNA Polymerase II Promoter Escape	0.191467	0.718
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.198188	0.703
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.201529	0.696
R-HSA-72165	mRNA Splicing - Minor Pathway	0.201529	0.696
R-HSA-167169	HIV Transcription Elongation	0.177856	0.750
R-HSA-72086	mRNA Capping	0.135655	0.868
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.064276	1.192
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.177856	0.750
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.174418	0.758
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	0.115575	0.937
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	0.115575	0.937
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	0.115575	0.937
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.059809	1.223
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	0.174418	0.758
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.177856	0.750
R-HSA-73980	RNA Polymerase III Transcription Termination	0.091322	1.039
R-HSA-8851708	Signaling by FGFR2 IIIa TM	0.095101	1.022
R-HSA-392517	Rap1 signalling	0.095101	1.022
R-HSA-3214815	HDACs deacetylate histones	0.230981	0.636
R-HSA-5655302	Signaling by FGFR1 in disease	0.184689	0.734
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	0.072196	1.141
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.087528	1.058
R-HSA-68877	Mitotic Prometaphase	0.220672	0.656
R-HSA-9942503	Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	0.079894	1.097
R-HSA-9945266	Differentiation of T cells	0.079894	1.097
R-HSA-9670095	Inhibition of DNA recombination at telomere	0.177856	0.750
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	0.060530	1.218
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.076053	1.119
R-HSA-9018519	Estrogen-dependent gene expression	0.133501	0.875
R-HSA-9675151	Disorders of Developmental Biology	0.083719	1.077
R-HSA-5617833	Cilium Assembly	0.216094	0.665
R-HSA-9768727	Regulation of CDH1 posttranslational processing and trafficking to plasma membra...	0.153492	0.814
R-HSA-69275	G2/M Transition	0.210004	0.678
R-HSA-453274	Mitotic G2-G2/M phases	0.213046	0.672
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	0.221284	0.655
R-HSA-9759475	Regulation of CDH11 Expression and Function	0.135655	0.868
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.124776	0.904
R-HSA-1852241	Organelle biogenesis and maintenance	0.168513	0.773
R-HSA-211000	Gene Silencing by RNA	0.088161	1.055
R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	0.149954	0.824
R-HSA-1839124	FGFR1 mutant receptor activation	0.149954	0.824
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.164020	0.785
R-HSA-1989781	PPARA activates gene expression	0.162181	0.790
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.167500	0.776
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	0.121120	0.917
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	0.165110	0.782
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	0.225259	0.647
R-HSA-1640170	Cell Cycle	0.186460	0.729
R-HSA-1266738	Developmental Biology	0.111648	0.952
R-HSA-1839126	FGFR2 mutant receptor activation	0.164020	0.785
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	0.190357	0.720
R-HSA-9764265	Regulation of CDH1 Expression and Function	0.190357	0.720
R-HSA-1834941	STING mediated induction of host immune responses	0.095101	1.022
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.181280	0.742
R-HSA-5621481	C-type lectin receptors (CLRs)	0.187358	0.727
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	0.198188	0.703
R-HSA-74158	RNA Polymerase III Transcription	0.164020	0.785
R-HSA-9758941	Gastrulation	0.153455	0.814
R-HSA-5655253	Signaling by FGFR2 in disease	0.214753	0.668
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.146401	0.834
R-HSA-75153	Apoptotic execution phase	0.201529	0.696
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	0.091944	1.036
R-HSA-166166	MyD88-independent TLR4 cascade	0.091944	1.036
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.085665	1.067
R-HSA-168898	Toll-like Receptor Cascades	0.217619	0.662
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.152011	0.818
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.234186	0.630
R-HSA-193648	NRAGE signals death through JNK	0.234186	0.630
R-HSA-5621480	Dectin-2 family	0.237379	0.625
R-HSA-1483166	Synthesis of PA	0.237379	0.625
R-HSA-6782135	Dual incision in TC-NER	0.240558	0.619
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.240558	0.619
R-HSA-5357801	Programmed Cell Death	0.240601	0.619
R-HSA-983189	Kinesins	0.246878	0.608
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.246878	0.608
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	0.246878	0.608
R-HSA-168325	Viral Messenger RNA Synthesis	0.250018	0.602
R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.253146	0.597
R-HSA-418990	Adherens junctions interactions	0.260621	0.584
R-HSA-597592	Post-translational protein modification	0.262029	0.582
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	0.265527	0.576
R-HSA-913709	O-linked glycosylation of mucins	0.271642	0.566
R-HSA-167172	Transcription of the HIV genome	0.271642	0.566
R-HSA-8878171	Transcriptional regulation by RUNX1	0.272959	0.564
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	0.277707	0.556
R-HSA-9764560	Regulation of CDH1 Gene Transcription	0.277707	0.556
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.277707	0.556
R-HSA-427413	NoRC negatively regulates rRNA expression	0.280721	0.552
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	0.280721	0.552
R-HSA-453276	Regulation of mitotic cell cycle	0.280721	0.552
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	0.280721	0.552
R-HSA-5578749	Transcriptional regulation by small RNAs	0.283722	0.547
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	0.283722	0.547
R-HSA-4086398	Ca2+ pathway	0.286711	0.543
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	0.286711	0.543
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.286711	0.543
R-HSA-69473	G2/M DNA damage checkpoint	0.289688	0.538
R-HSA-8939211	ESR-mediated signaling	0.289915	0.538
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.292652	0.534
R-HSA-8852135	Protein ubiquitination	0.292652	0.534
R-HSA-383280	Nuclear Receptor transcription pathway	0.301472	0.521
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.301472	0.521
R-HSA-416482	G alpha (12/13) signalling events	0.301472	0.521
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.307292	0.512
R-HSA-5654738	Signaling by FGFR2	0.307292	0.512
R-HSA-5693607	Processing of DNA double-strand break ends	0.310184	0.508
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.310184	0.508
R-HSA-421270	Cell-cell junction organization	0.311435	0.507
R-HSA-74160	Gene expression (Transcription)	0.312176	0.506
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.318789	0.496
R-HSA-69620	Cell Cycle Checkpoints	0.322152	0.492
R-HSA-141424	Amplification of signal from the kinetochores	0.324467	0.489
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.324467	0.489
R-HSA-73884	Base Excision Repair	0.338458	0.470
R-HSA-8986944	Transcriptional Regulation by MECP2	0.341222	0.467
R-HSA-446728	Cell junction organization	0.352540	0.453
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.360253	0.443
R-HSA-6807878	COPI-mediated anterograde transport	0.360253	0.443
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.360253	0.443
R-HSA-5607764	CLEC7A (Dectin-1) signaling	0.360253	0.443
R-HSA-157579	Telomere Maintenance	0.362927	0.440
R-HSA-190236	Signaling by FGFR	0.365590	0.437
R-HSA-3214847	HATs acetylate histones	0.368242	0.434
R-HSA-193704	p75 NTR receptor-mediated signalling	0.368242	0.434
R-HSA-69618	Mitotic Spindle Checkpoint	0.370883	0.431
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.376133	0.425
R-HSA-195721	Signaling by WNT	0.382473	0.417
R-HSA-5696398	Nucleotide Excision Repair	0.386504	0.413
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.396704	0.402
R-HSA-1500931	Cell-Cell communication	0.408923	0.388
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.409220	0.388
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.416607	0.380
R-HSA-373760	L1CAM interactions	0.419049	0.378
R-HSA-1592230	Mitochondrial biogenesis	0.421480	0.375
R-HSA-5693538	Homology Directed Repair	0.423902	0.373
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.431108	0.365
R-HSA-3371556	Cellular response to heat stress	0.431108	0.365
R-HSA-73886	Chromosome Maintenance	0.431108	0.365
R-HSA-2132295	MHC class II antigen presentation	0.435862	0.361
R-HSA-69278	Cell Cycle, Mitotic	0.443436	0.353
R-HSA-69481	G2/M Checkpoints	0.447577	0.349
R-HSA-5683057	MAPK family signaling cascades	0.453178	0.344
R-HSA-9843745	Adipogenesis	0.459053	0.338
R-HSA-8856688	Golgi-to-ER retrograde transport	0.461320	0.336
R-HSA-3858494	Beta-catenin independent WNT signaling	0.472514	0.326
R-HSA-5173105	O-linked glycosylation	0.474725	0.324
R-HSA-9006931	Signaling by Nuclear Receptors	0.475297	0.323
R-HSA-162599	Late Phase of HIV Life Cycle	0.487802	0.312
R-HSA-199977	ER to Golgi Anterograde Transport	0.498454	0.302
R-HSA-68886	M Phase	0.502194	0.299
R-HSA-9679191	Potential therapeutics for SARS	0.504740	0.297
R-HSA-9856651	MITF-M-dependent gene expression	0.504740	0.297
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.515045	0.288
R-HSA-162587	HIV Life Cycle	0.519107	0.285
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.521126	0.283
R-HSA-109581	Apoptosis	0.529117	0.276
R-HSA-199991	Membrane Trafficking	0.530593	0.275
R-HSA-2467813	Separation of Sister Chromatids	0.533064	0.273
R-HSA-9909648	Regulation of PD-L1(CD274) expression	0.550423	0.259
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.556066	0.255
R-HSA-168255	Influenza Infection	0.563483	0.249
R-HSA-201681	TCF dependent signaling in response to WNT	0.570778	0.244
R-HSA-3781865	Diseases of glycosylation	0.572583	0.242
R-HSA-73857	RNA Polymerase II Transcription	0.579705	0.237
R-HSA-72163	mRNA Splicing - Major Pathway	0.590225	0.229
R-HSA-389948	Co-inhibition by PD-1	0.600463	0.222
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.600463	0.222
R-HSA-428157	Sphingolipid metabolism	0.602145	0.220
R-HSA-948021	Transport to the Golgi and subsequent modification	0.603820	0.219
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.605488	0.218
R-HSA-376176	Signaling by ROBO receptors	0.605488	0.218
R-HSA-1483206	Glycerophospholipid biosynthesis	0.605488	0.218
R-HSA-72172	mRNA Splicing	0.608803	0.216
R-HSA-9730414	MITF-M-regulated melanocyte development	0.623384	0.205
R-HSA-68882	Mitotic Anaphase	0.628124	0.202
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.629691	0.201
R-HSA-162582	Signal Transduction	0.633404	0.198
R-HSA-162906	HIV Infection	0.645008	0.190
R-HSA-1280218	Adaptive Immune System	0.655900	0.183
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.657705	0.182
R-HSA-168249	Innate Immune System	0.671122	0.173
R-HSA-5653656	Vesicle-mediated transport	0.676897	0.169
R-HSA-388841	Regulation of T cell activation by CD28 family	0.685984	0.164
R-HSA-422475	Axon guidance	0.687033	0.163
R-HSA-392499	Metabolism of proteins	0.698671	0.156
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.715138	0.146
R-HSA-9675108	Nervous system development	0.720388	0.142
R-HSA-1483257	Phospholipid metabolism	0.733828	0.134
R-HSA-212436	Generic Transcription Pathway	0.795559	0.099
R-HSA-2262752	Cellular responses to stress	0.815018	0.089
R-HSA-446203	Asparagine N-linked glycosylation	0.845726	0.073
R-HSA-5668914	Diseases of metabolism	0.848992	0.071
R-HSA-3700989	Transcriptional Regulation by TP53	0.871683	0.060
R-HSA-8953897	Cellular responses to stimuli	0.871937	0.060
R-HSA-8953854	Metabolism of RNA	0.877441	0.057
R-HSA-556833	Metabolism of lipids	0.884148	0.053
R-HSA-9679506	SARS-CoV Infections	0.912881	0.040
R-HSA-168256	Immune System	0.913833	0.039
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.932202	0.030
R-HSA-1280215	Cytokine Signaling in Immune system	0.947414	0.023
R-HSA-9824446	Viral Infection Pathways	0.956716	0.019
R-HSA-388396	GPCR downstream signalling	0.966366	0.015
R-HSA-109582	Hemostasis	0.967807	0.014
R-HSA-372790	Signaling by GPCR	0.976634	0.010
R-HSA-5663205	Infectious disease	0.995190	0.002
R-HSA-1643685	Disease	0.995267	0.002
R-HSA-1430728	Metabolism	0.999972	0.000

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kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
CDK1	0.782	0.592	1	0.908
CDK3	0.780	0.536	1	0.923
JNK2	0.776	0.619	1	0.929
KIS	0.776	0.503	1	0.903
CDK19	0.775	0.563	1	0.915
P38G	0.774	0.594	1	0.930
CDK7	0.772	0.566	1	0.907
CDK18	0.772	0.564	1	0.922
CDK17	0.770	0.577	1	0.925
CDK8	0.770	0.554	1	0.900
JNK3	0.769	0.602	1	0.918
CDK13	0.769	0.550	1	0.919
P38B	0.768	0.582	1	0.915
HIPK2	0.768	0.514	1	0.923
ERK1	0.767	0.561	1	0.926
P38D	0.767	0.577	1	0.937
CDK12	0.766	0.549	1	0.929
HIPK4	0.765	0.367	1	0.747
DYRK2	0.764	0.506	1	0.890
CDK5	0.764	0.528	1	0.896
DYRK4	0.762	0.513	1	0.928
CDK9	0.761	0.535	1	0.916
CLK3	0.759	0.343	1	0.700
P38A	0.757	0.543	1	0.888
CDK14	0.756	0.539	1	0.909
CDK16	0.755	0.537	1	0.923
JNK1	0.753	0.540	1	0.916
ERK2	0.753	0.539	1	0.904
NLK	0.753	0.472	1	0.752
CDK10	0.752	0.501	1	0.918
CDK2	0.751	0.438	1	0.845
ERK5	0.750	0.300	1	0.671
SRPK1	0.750	0.238	-3	0.644
CDK6	0.749	0.524	1	0.918
HIPK1	0.749	0.457	1	0.874
DYRK1B	0.748	0.476	1	0.906
CDK4	0.747	0.530	1	0.932
DYRK1A	0.746	0.404	1	0.867
MTOR	0.744	0.186	1	0.562
HIPK3	0.742	0.435	1	0.870
ICK	0.739	0.273	-3	0.740
CLK2	0.737	0.262	-3	0.622
COT	0.736	0.019	2	0.684
MAK	0.735	0.381	-2	0.775
DYRK3	0.734	0.349	1	0.851
CDC7	0.734	-0.001	1	0.384
SRPK2	0.733	0.175	-3	0.571
CDKL5	0.733	0.126	-3	0.703
CLK1	0.732	0.252	-3	0.617
MOS	0.731	0.054	1	0.447
CLK4	0.730	0.229	-3	0.641
CDKL1	0.729	0.096	-3	0.701
SRPK3	0.728	0.152	-3	0.617
IKKB	0.728	-0.056	-2	0.772
ATR	0.727	0.017	1	0.476
NDR2	0.726	0.018	-3	0.748
PIM3	0.725	0.012	-3	0.727
PRPK	0.724	-0.092	-1	0.827
CHAK2	0.724	-0.006	-1	0.787
TBK1	0.723	-0.100	1	0.380
GCN2	0.723	-0.137	2	0.667
GSK3A	0.723	0.149	4	0.225
GRK1	0.723	0.023	-2	0.815
IKKE	0.722	-0.093	1	0.373
NEK6	0.722	-0.025	-2	0.821
PDHK4	0.722	-0.091	1	0.480
PRKD1	0.722	0.020	-3	0.730
PRP4	0.721	0.277	-3	0.629
MOK	0.721	0.326	1	0.797
GRK5	0.720	-0.031	-3	0.744
BMPR2	0.719	-0.089	-2	0.864
IKKA	0.719	-0.016	-2	0.770
RAF1	0.719	-0.145	1	0.418
PDHK1	0.718	-0.109	1	0.461
DNAPK	0.718	0.017	1	0.444
ERK7	0.717	0.179	2	0.430
MLK2	0.717	0.014	2	0.661
CAMK2G	0.717	-0.063	2	0.635
CAMK1B	0.716	-0.046	-3	0.739
ULK2	0.716	-0.135	2	0.643
TGFBR2	0.716	-0.038	-2	0.773
BCKDK	0.716	-0.093	-1	0.795
SKMLCK	0.715	-0.023	-2	0.818
P90RSK	0.715	0.010	-3	0.669
RSK2	0.715	0.014	-3	0.665
MASTL	0.715	-0.060	-2	0.825
NEK7	0.715	-0.117	-3	0.777
RIPK3	0.714	-0.097	3	0.525
DSTYK	0.714	-0.104	2	0.693
WNK1	0.714	-0.093	-2	0.840
CAMK2D	0.714	-0.015	-3	0.733
MLK1	0.714	-0.108	2	0.648
MLK3	0.714	0.000	2	0.578
NIK	0.713	-0.050	-3	0.754
NUAK2	0.713	-0.047	-3	0.716
GRK7	0.713	0.037	1	0.415
NDR1	0.713	-0.044	-3	0.721
MAPKAPK2	0.712	0.009	-3	0.623
CAMLCK	0.712	-0.026	-2	0.814
MPSK1	0.712	0.098	1	0.470
SMG1	0.712	-0.004	1	0.454
GSK3B	0.711	0.046	4	0.223
MAPKAPK3	0.711	-0.025	-3	0.666
CAMK2A	0.711	0.020	2	0.633
IRE1	0.711	-0.090	1	0.431
GRK4	0.711	-0.067	-2	0.826
GRK6	0.711	-0.071	1	0.402
PKN3	0.711	-0.045	-3	0.710
PRKD2	0.711	-0.005	-3	0.656
HUNK	0.710	-0.160	2	0.690
RSK3	0.710	-0.011	-3	0.649
MST4	0.709	-0.083	2	0.702
ATM	0.709	-0.060	1	0.429
DAPK2	0.709	-0.045	-3	0.754
PIM1	0.709	0.003	-3	0.666
DLK	0.709	-0.089	1	0.425
LATS2	0.708	-0.027	-5	0.683
NEK9	0.708	-0.129	2	0.690
TLK2	0.708	-0.001	1	0.431
ULK1	0.707	-0.127	-3	0.722
ALK4	0.707	-0.004	-2	0.831
AMPKA1	0.707	-0.095	-3	0.734
PKN2	0.707	-0.070	-3	0.708
PKCD	0.706	-0.029	2	0.620
RIPK1	0.706	-0.132	1	0.427
TGFBR1	0.706	-0.007	-2	0.806
PHKG1	0.706	-0.049	-3	0.702
VRK2	0.706	0.032	1	0.525
AURC	0.705	0.005	-2	0.596
CAMK2B	0.704	-0.026	2	0.582
WNK3	0.704	-0.216	1	0.437
MARK4	0.704	-0.127	4	0.455
AMPKA2	0.704	-0.076	-3	0.704
PKCA	0.703	-0.013	2	0.574
YSK4	0.703	-0.061	1	0.384
ANKRD3	0.703	-0.111	1	0.454
PKACG	0.703	-0.044	-2	0.691
IRE2	0.702	-0.072	2	0.596
CHAK1	0.702	-0.118	2	0.676
PINK1	0.702	0.083	1	0.603
BMPR1B	0.702	-0.015	1	0.333
PKCZ	0.701	-0.049	2	0.631
PKCG	0.701	-0.043	2	0.581
LATS1	0.701	0.008	-3	0.763
PKCB	0.700	-0.041	2	0.579
TTBK2	0.700	-0.136	2	0.574
RSK4	0.700	0.011	-3	0.651
NEK2	0.700	-0.101	2	0.684
TSSK1	0.699	-0.095	-3	0.754
MEK1	0.699	-0.097	2	0.707
P70S6KB	0.699	-0.048	-3	0.675
PAK3	0.699	-0.066	-2	0.747
MLK4	0.698	-0.058	2	0.554
MSK1	0.698	-0.011	-3	0.641
AKT2	0.698	0.017	-3	0.575
CAMK4	0.698	-0.095	-3	0.696
NIM1	0.698	-0.132	3	0.524
MSK2	0.698	-0.044	-3	0.644
PAK1	0.698	-0.053	-2	0.746
MNK2	0.697	-0.056	-2	0.740
NUAK1	0.697	-0.070	-3	0.667
PRKD3	0.697	-0.032	-3	0.622
PAK6	0.697	-0.016	-2	0.672
TSSK2	0.697	-0.120	-5	0.783
PKR	0.696	-0.115	1	0.455
MELK	0.696	-0.085	-3	0.686
PLK1	0.696	-0.107	-2	0.777
PASK	0.696	0.054	-3	0.764
QSK	0.695	-0.091	4	0.440
ACVR2A	0.695	-0.056	-2	0.767
ALK2	0.695	-0.049	-2	0.814
MNK1	0.694	-0.044	-2	0.752
CK1E	0.694	-0.015	-3	0.492
ACVR2B	0.694	-0.054	-2	0.779
PKG2	0.694	-0.019	-2	0.607
CHK1	0.694	-0.023	-3	0.721
PKACB	0.693	-0.002	-2	0.606
PLK3	0.693	-0.099	2	0.614
PERK	0.692	-0.109	-2	0.816
PKCH	0.692	-0.082	2	0.574
HRI	0.692	-0.139	-2	0.822
PAK2	0.692	-0.074	-2	0.740
PLK4	0.691	-0.083	2	0.516
DCAMKL1	0.691	-0.048	-3	0.648
BRSK2	0.691	-0.120	-3	0.691
NEK5	0.691	-0.077	1	0.443
MEK5	0.691	-0.121	2	0.683
SGK3	0.691	-0.035	-3	0.648
AURB	0.690	-0.036	-2	0.598
QIK	0.690	-0.160	-3	0.726
MST3	0.690	-0.064	2	0.702
PIM2	0.690	-0.009	-3	0.633
ZAK	0.690	-0.102	1	0.396
GRK2	0.690	-0.067	-2	0.733
CK1D	0.690	0.010	-3	0.447
LKB1	0.689	0.026	-3	0.745
SNRK	0.689	-0.149	2	0.555
MYLK4	0.688	-0.061	-2	0.724
PRKX	0.688	-0.001	-3	0.573
MEKK1	0.688	-0.144	1	0.439
TLK1	0.688	-0.096	-2	0.805
IRAK4	0.688	-0.120	1	0.420
TAO3	0.688	-0.049	1	0.439
DRAK1	0.687	-0.111	1	0.353
WNK4	0.687	-0.149	-2	0.840
MAPKAPK5	0.686	-0.086	-3	0.612
MEKK3	0.686	-0.147	1	0.423
NEK11	0.686	-0.085	1	0.434
BRSK1	0.686	-0.110	-3	0.663
AURA	0.686	-0.042	-2	0.577
GCK	0.686	-0.014	1	0.427
MEKK2	0.686	-0.107	2	0.655
SIK	0.685	-0.104	-3	0.634
FAM20C	0.685	-0.083	2	0.382
PDK1	0.684	-0.031	1	0.453
CK1G1	0.684	-0.046	-3	0.462
DCAMKL2	0.684	-0.060	-3	0.674
MARK3	0.684	-0.122	4	0.395
AKT1	0.683	-0.012	-3	0.593
PKCT	0.682	-0.078	2	0.575
BRAF	0.682	-0.094	-4	0.715
BMPR1A	0.682	-0.047	1	0.313
GAK	0.682	-0.024	1	0.456
CAMK1G	0.682	-0.089	-3	0.636
CK1A2	0.682	-0.017	-3	0.444
PKCI	0.682	-0.065	2	0.609
PBK	0.681	0.015	1	0.427
EEF2K	0.681	-0.054	3	0.649
CAMKK2	0.681	-0.042	-2	0.757
PAK4	0.681	-0.019	-2	0.623
AKT3	0.681	0.036	-3	0.524
MARK2	0.681	-0.142	4	0.383
TAK1	0.681	-0.037	1	0.418
HGK	0.681	-0.045	3	0.646
CAMKK1	0.680	-0.110	-2	0.760
NEK8	0.680	-0.117	2	0.671
LRRK2	0.680	-0.028	2	0.702
TTBK1	0.680	-0.126	2	0.513
TNIK	0.680	-0.030	3	0.651
SBK	0.680	0.077	-3	0.460
PAK5	0.680	-0.039	-2	0.617
NEK4	0.679	-0.101	1	0.423
PKCE	0.679	-0.044	2	0.578
HPK1	0.679	-0.043	1	0.420
TAO2	0.678	-0.093	2	0.680
P70S6K	0.677	-0.056	-3	0.599
SLK	0.677	-0.028	-2	0.719
GRK3	0.677	-0.071	-2	0.692
KHS1	0.677	-0.028	1	0.423
SMMLCK	0.677	-0.074	-3	0.702
CK2A2	0.677	-0.068	1	0.273
PKACA	0.676	-0.022	-2	0.548
MAP3K15	0.676	-0.084	1	0.409
PKN1	0.676	-0.044	-3	0.608
SSTK	0.676	-0.118	4	0.442
MEKK6	0.676	-0.110	1	0.431
MINK	0.676	-0.089	1	0.409
IRAK1	0.675	-0.171	-1	0.777
LOK	0.675	-0.050	-2	0.755
PHKG2	0.675	-0.139	-3	0.653
STK33	0.674	-0.084	2	0.505
KHS2	0.674	-0.021	1	0.435
NEK1	0.674	-0.100	1	0.423
MARK1	0.674	-0.157	4	0.409
BUB1	0.673	0.007	-5	0.692
PLK2	0.673	-0.052	-3	0.670
SGK1	0.672	0.000	-3	0.510
MST2	0.671	-0.109	1	0.416
CK2A1	0.670	-0.072	1	0.256
CAMK1D	0.670	-0.066	-3	0.575
VRK1	0.668	-0.158	2	0.683
RIPK2	0.668	-0.171	1	0.374
MST1	0.667	-0.105	1	0.409
YSK1	0.667	-0.098	2	0.671
MRCKA	0.667	-0.043	-3	0.630
CHK2	0.666	-0.047	-3	0.512
ROCK2	0.665	-0.039	-3	0.671
MRCKB	0.665	-0.038	-3	0.615
NEK3	0.664	-0.093	1	0.429
HASPIN	0.664	-0.029	-1	0.648
OSR1	0.663	-0.045	2	0.671
YANK3	0.663	-0.032	2	0.306
MEK2	0.663	-0.158	2	0.680
DAPK3	0.663	-0.080	-3	0.671
DAPK1	0.662	-0.067	-3	0.661
CRIK	0.660	-0.002	-3	0.605
CAMK1A	0.660	-0.055	-3	0.525
BIKE	0.660	-0.020	1	0.408
MYO3B	0.659	-0.065	2	0.681
PDHK3_TYR	0.656	0.159	4	0.519
ASK1	0.655	-0.098	1	0.394
DMPK1	0.655	-0.021	-3	0.620
CK1A	0.654	-0.034	-3	0.361
MYO3A	0.654	-0.082	1	0.431
AAK1	0.654	0.013	1	0.380
PKG1	0.652	-0.056	-2	0.506
TAO1	0.652	-0.113	1	0.400
PDHK4_TYR	0.651	0.109	2	0.721
MAP2K4_TYR	0.650	0.094	-1	0.834
TTK	0.649	-0.113	-2	0.787
ROCK1	0.648	-0.068	-3	0.625
LIMK2_TYR	0.648	0.098	-3	0.787
ALPHAK3	0.647	-0.076	-1	0.731
MAP2K6_TYR	0.647	0.050	-1	0.845
TESK1_TYR	0.646	0.037	3	0.625
PKMYT1_TYR	0.645	0.027	3	0.590
STLK3	0.643	-0.121	1	0.384
MAP2K7_TYR	0.641	-0.085	2	0.704
BMPR2_TYR	0.640	0.009	-1	0.819
PDHK1_TYR	0.640	-0.004	-1	0.834
PINK1_TYR	0.634	-0.178	1	0.468
LIMK1_TYR	0.633	-0.084	2	0.695
RET	0.633	-0.128	1	0.453
CSF1R	0.632	-0.100	3	0.507
YANK2	0.632	-0.046	2	0.308
FGR	0.631	-0.080	1	0.425
TNNI3K_TYR	0.630	-0.034	1	0.474
ROS1	0.630	-0.137	3	0.499
JAK2	0.630	-0.138	1	0.457
CK1G3	0.630	-0.043	-3	0.317
MST1R	0.630	-0.139	3	0.520
DDR1	0.629	-0.135	4	0.479
TYRO3	0.628	-0.134	3	0.525
TXK	0.628	-0.031	1	0.372
NEK10_TYR	0.628	-0.078	1	0.374
EPHA6	0.627	-0.089	-1	0.789
EPHB4	0.627	-0.094	-1	0.788
TYK2	0.627	-0.239	1	0.443
TNK1	0.626	-0.063	3	0.510
JAK1	0.625	-0.094	1	0.412
JAK3	0.625	-0.124	1	0.422
TNK2	0.625	-0.062	3	0.455
YES1	0.624	-0.109	-1	0.803
FGFR2	0.624	-0.062	3	0.521
TEK	0.624	-0.030	3	0.467
LCK	0.623	-0.083	-1	0.804
ITK	0.623	-0.093	-1	0.807
HCK	0.622	-0.133	-1	0.807
ABL2	0.622	-0.129	-1	0.773
BLK	0.620	-0.087	-1	0.788
KIT	0.620	-0.130	3	0.513
FER	0.620	-0.166	1	0.423
SRMS	0.620	-0.124	1	0.391
EPHA4	0.619	-0.083	2	0.617
FGFR1	0.619	-0.075	3	0.469
KDR	0.618	-0.098	3	0.481
WEE1_TYR	0.618	-0.078	-1	0.750
ABL1	0.618	-0.139	-1	0.763
MET	0.617	-0.105	3	0.483
EPHB1	0.616	-0.141	1	0.395
CK1G2	0.616	-0.043	-3	0.392
FYN	0.616	-0.070	-1	0.784
PTK6	0.616	-0.116	-1	0.763
EPHB3	0.615	-0.123	-1	0.781
INSRR	0.615	-0.180	3	0.474
AXL	0.615	-0.130	3	0.482
BMX	0.614	-0.099	-1	0.705
DDR2	0.614	-0.091	3	0.454
MERTK	0.614	-0.128	3	0.479
PDGFRB	0.613	-0.211	3	0.519
FLT1	0.613	-0.089	-1	0.793
FGFR3	0.612	-0.085	3	0.495
PDGFRA	0.612	-0.192	3	0.523
EPHB2	0.611	-0.148	-1	0.765
BTK	0.610	-0.192	-1	0.778
EPHA7	0.610	-0.104	2	0.619
LYN	0.609	-0.120	3	0.464
FLT4	0.608	-0.139	3	0.498
TEC	0.608	-0.152	-1	0.714
ERBB2	0.607	-0.145	1	0.397
FLT3	0.607	-0.243	3	0.519
NTRK3	0.607	-0.109	-1	0.762
NTRK1	0.606	-0.191	-1	0.801
SRC	0.606	-0.108	-1	0.766
FRK	0.605	-0.159	-1	0.788
EPHA3	0.605	-0.135	2	0.586
ALK	0.604	-0.193	3	0.422
EPHA1	0.604	-0.159	3	0.460
INSR	0.602	-0.194	3	0.461
NTRK2	0.602	-0.206	3	0.473
EGFR	0.600	-0.101	1	0.348
MATK	0.600	-0.105	-1	0.682
FGFR4	0.599	-0.095	-1	0.730
PTK2B	0.599	-0.132	-1	0.739
LTK	0.598	-0.203	3	0.449
CSK	0.598	-0.138	2	0.617
EPHA8	0.598	-0.117	-1	0.761
SYK	0.597	-0.075	-1	0.740
PTK2	0.597	-0.066	-1	0.736
EPHA5	0.595	-0.151	2	0.590
MUSK	0.595	-0.136	1	0.341
ERBB4	0.594	-0.076	1	0.340
EPHA2	0.593	-0.104	-1	0.732
IGF1R	0.589	-0.170	3	0.414
ZAP70	0.588	-0.031	-1	0.676
FES	0.576	-0.160	-1	0.681