Motif 1073 (n=187)

Position-wise Probabilities

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uniprot genes site source protein function
A1A4S6 ARHGAP10 T633 ochoa Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}.
A6NKT7 RGPD3 T1500 ochoa RanBP2-like and GRIP domain-containing protein 3 None
O14641 DVL2 T206 psp Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}.
O14757 CHEK1 T330 ochoa Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}.
O14867 BACH1 T360 ochoa Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}.
O43164 PJA2 T279 ochoa E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}.
O43399 TPD52L2 T163 ochoa Tumor protein D54 (hD54) (Tumor protein D52-like 2) None
O60315 ZEB2 T1117 ochoa Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}.
O60716 CTNND1 T932 ochoa Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}.
O75116 ROCK2 T1214 ochoa Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.
O75369 FLNB T2110 ochoa Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
O75717 WDHD1 T310 ochoa WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}.
O75937 DNAJC8 T47 ochoa DnaJ homolog subfamily C member 8 (Splicing protein spf31) Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}.
O95049 TJP3 T588 ochoa Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}.
O95197 RTN3 T588 ochoa Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}.
O95425 SVIL T79 ochoa Supervillin (Archvillin) (p205/p250) [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}.
O95671 ASMTL T234 ochoa Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}.
O96017 CHEK2 T432 psp Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}.
P00533 EGFR T1078 ochoa Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.
P01106 MYC T358 psp Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}.
P02545 LMNA T590 ochoa Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P02749 APOH T189 ochoa Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI) Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
P05455 SSB T362 ochoa Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}.
P06732 CKM T103 ochoa Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}.
P08670 VIM T361 ochoa Vimentin Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}.
P09884 POLA1 T406 ochoa DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}.
P0DJD0 RGPD1 T1484 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 T1492 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P0DPH7 TUBA3C T41 ochoa Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P0DPH8 TUBA3D T41 ochoa Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P11166 SLC2A1 T234 ochoa Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter) Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:10227690, PubMed:10954735, PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:32860739). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P17809, ECO:0000250|UniProtKB:P46896, ECO:0000269|PubMed:10227690, ECO:0000269|PubMed:10954735, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:27078104, ECO:0000269|PubMed:32860739}.
P11169 SLC2A3 T232 ochoa Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:26176916, PubMed:9477959). Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P32037, ECO:0000269|PubMed:26176916, ECO:0000269|PubMed:32860739, ECO:0000269|PubMed:8457197, ECO:0000269|PubMed:9477959}.
P11908 PRPS2 T285 psp Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II) Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
P12882 MYH1 T1855 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 T1653 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 T1851 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 T1655 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 T1854 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P16144 ITGB4 T1514 ochoa Integrin beta-4 (GP150) (CD antigen CD104) Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.
P17676 CEBPB T266 psp CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}.
P20290 BTF3 T182 ochoa Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}.
P20929 NEB T35 ochoa Nebulin This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin.
P21333 FLNA T2530 ochoa Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.
P23497 SP100 T221 ochoa Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.
P26232 CTNNA2 T653 ochoa Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}.
P29972 AQP1 T157 psp Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel) Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:16682607, ECO:0000269|PubMed:17012249, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:33028705, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:36949749, ECO:0000269|PubMed:8584435, ECO:0000269|PubMed:8703053}.
P31943 HNRNPH1 T100 ochoa Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.
P32519 ELF1 T180 ochoa ETS-related transcription factor Elf-1 (E74-like factor 1) Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}.
P35606 COPB2 T848 ochoa Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}.
P36871 PGM1 T513 ochoa Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}.
P38432 COIL T485 ochoa Coilin (p80-coilin) Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}.
P42694 HELZ T1572 ochoa Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
P43243 MATR3 T155 ochoa Matrin-3 May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}.
P46013 MKI67 T167 ochoa Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}.
P46100 ATRX T724 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P46100 ATRX T1534 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P48681 NES T322 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P49757 NUMB T102 psp Protein numb homolog (h-Numb) (Protein S171) Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}.
P49792 RANBP2 T2475 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P49796 RGS3 T960 ochoa Regulator of G-protein signaling 3 (RGP3) (RGS3) Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}.
P52292 KPNA2 T73 ochoa Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}.
P55795 HNRNPH2 T100 ochoa Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).
P62258 YWHAE T232 ochoa 14-3-3 protein epsilon (14-3-3E) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}.
P68363 TUBA1B T41 ochoa Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}.
Q01130 SRSF2 T22 ochoa Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}.
Q02410 APBA1 T89 ochoa Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}.
Q03431 PTH1R T392 psp Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}.
Q04637 EIF4G1 T1073 ochoa Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}.
Q05209 PTPN12 T598 ochoa Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
Q09666 AHNAK T38 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q09666 AHNAK T190 ochoa Neuroblast differentiation-associated protein AHNAK (Desmoyokin) May be required for neuronal cell differentiation.
Q12968 NFATC3 T340 ochoa Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}.
Q13017 ARHGAP5 T1217 ochoa Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}.
Q13123 IK T329 ochoa Protein Red (Cytokine IK) (IK factor) (Protein RER) Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}.
Q13315 ATM T1884 ochoa Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.
Q13535 ATR T1566 psp Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:27723717, PubMed:27723720, PubMed:30139873, PubMed:33848395, PubMed:37788673, PubMed:37832547, PubMed:9427750, PubMed:9636169). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:23273981, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:9925639). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (PubMed:30139873). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (PubMed:25083873, PubMed:37788673, PubMed:37832547). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (PubMed:37832547). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (PubMed:37788673). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (PubMed:37788673). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:33848395, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}.
Q13561 DCTN2 T195 ochoa Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}.
Q14324 MYBPC2 T989 ochoa Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Q14676 MDC1 T448 ochoa Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}.
Q15149 PLEC T351 ochoa Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
Q15554 TERF2 T230 psp Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). {ECO:0000250|UniProtKB:O35144, ECO:0000269|PubMed:15608617, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:9326950, ECO:0000269|PubMed:9326951, ECO:0000269|PubMed:9476899}.
Q15762 CD226 T310 ochoa CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226) Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:9712030). Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:26755705, PubMed:31253644, PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity). {ECO:0000250|UniProtKB:Q8K4F0, ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:30591568, ECO:0000269|PubMed:31253644, ECO:0000269|PubMed:8673704, ECO:0000269|PubMed:9712030}.
Q16236 NFE2L2 T369 psp Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}.
Q32MZ4 LRRFIP1 T533 ochoa Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}.
Q58WW2 DCAF6 T654 ochoa DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.
Q5H9L2 TCEAL5 T120 ochoa Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) May be involved in transcriptional regulation.
Q5H9L2 TCEAL5 T124 ochoa Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) May be involved in transcriptional regulation.
Q5VUJ6 LRCH2 T360 ochoa Leucine-rich repeat and calponin homology domain-containing protein 2 May play a role in the organization of the cytoskeleton. {ECO:0000250|UniProtKB:Q960C5, ECO:0000250|UniProtKB:Q96II8}.
Q641Q2 WASHC2A T479 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q641Q2 WASHC2A T799 ochoa WASH complex subunit 2A Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}.
Q68D20 PMS2CL T156 ochoa Protein PMS2CL (PMS2-C terminal-like protein) None
Q68D85 NCR3LG1 T393 ochoa Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}.
Q6IPX3 TCEAL6 T114 ochoa Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6) May be involved in transcriptional regulation.
Q6IPX3 TCEAL6 T118 ochoa Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6) May be involved in transcriptional regulation.
Q6IQ55 TTBK2 T574 ochoa Tau-tubulin kinase 2 (EC 2.7.11.1) Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}.
Q6KC79 NIPBL T2667 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6PEY2 TUBA3E T41 ochoa Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q6PIJ6 FBXO38 T591 ochoa F-box only protein 38 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}.
Q6UB99 ANKRD11 T829 ochoa Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.
Q6UWZ7 ABRAXAS1 T46 ochoa BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538, ECO:0000269|PubMed:26778126}.
Q709C8 VPS13C T869 ochoa Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}.
Q71U36 TUBA1A T41 ochoa Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q7Z3D4 LYSMD3 T54 ochoa LysM and putative peptidoglycan-binding domain-containing protein 3 Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}.
Q7Z3J3 RGPD4 T1500 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q86UE4 MTDH T212 ochoa Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.
Q86V21 AACS T83 ochoa Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}.
Q86V48 LUZP1 T953 ochoa Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}.
Q8N1F7 NUP93 T51 ochoa Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.
Q8N1W1 ARHGEF28 T509 ochoa Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}.
Q8N5F7 NKAP T298 ochoa NF-kappa-B-activating protein Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}.
Q8NC44 RETREG2 T306 ochoa Reticulophagy regulator 2 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}.
Q8NC44 RETREG2 T329 ochoa Reticulophagy regulator 2 Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}.
Q8TBB5 KLHDC4 T403 ochoa Kelch domain-containing protein 4 None
Q8TDB8 SLC2A14 T256 ochoa Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14) Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane. {ECO:0000269|PubMed:28971850}.
Q8TDD1 DDX54 T70 ochoa ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}.
Q969E4 TCEAL3 T114 ochoa Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) May be involved in transcriptional regulation.
Q969E4 TCEAL3 T118 ochoa Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) May be involved in transcriptional regulation.
Q96B36 AKT1S1 T198 ochoa Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}.
Q96B97 SH3KBP1 T178 ochoa SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}.
Q96EY7 PTCD3 T670 ochoa Small ribosomal subunit protein mS39 (28S ribosomal protein S39, mitochondrial) (MRP-S39) (Pentatricopeptide repeat domain-containing protein 3, mitochondrial) (Transformation-related gene 15 protein) (TRG-15) Mitochondrial RNA-binding protein that has a role in mitochondrial translation. {ECO:0000269|PubMed:19427859}.
Q99497 PARK7 T125 psp Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:14749723, PubMed:15502874, PubMed:17015834, PubMed:18711745, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:26995087, PubMed:28013050). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:28993701, PubMed:31653696). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:16632486, PubMed:19229105). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:28993701, ECO:0000269|PubMed:30150385, ECO:0000269|PubMed:30894531, ECO:0000269|PubMed:9070310}.
Q9BQE3 TUBA1C T41 ochoa Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q9BRL6 SRSF8 T22 ochoa Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}.
Q9BTC0 DIDO1 T328 ochoa Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.
Q9BUZ4 TRAF4 T422 ochoa TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273). {ECO:0000250, ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600, ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:30352854, ECO:0000269|PubMed:31076633, ECO:0000269|PubMed:32268273, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33991522}.
Q9BY89 KIAA1671 T1380 ochoa Uncharacterized protein KIAA1671 None
Q9BYW2 SETD2 T1951 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9C0C2 TNKS1BP1 T1154 ochoa 182 kDa tankyrase-1-binding protein None
Q9H1D0 TRPV6 T728 psp Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}.
Q9H2Y7 ZNF106 T1467 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H334 FOXP1 T654 ochoa Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}.
Q9H3M7 TXNIP T348 ochoa Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850). {ECO:0000250|UniProtKB:Q8BG60, ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
Q9H501 ESF1 T311 ochoa ESF1 homolog (ABT1-associated protein) May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.
Q9H9C1 VIPAS39 T21 ochoa Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}.
Q9HAJ7 SAP30L T92 ochoa Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). {ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240, ECO:0000269|PubMed:26609676}.; FUNCTION: [Isoform 2]: Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:18070604}.; FUNCTION: [Isoform 3]: Functions as a transcription repressor; its activity is marginally lower than that of isoform 1. {ECO:0000269|PubMed:18070604}.
Q9HBG7 LY9 T532 ochoa T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229) Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). {ECO:0000250|UniProtKB:Q01965, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.
Q9NQS5 GPR84 T264 psp G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33) G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists (PubMed:16966319). In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (By similarity). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (By similarity). Also plays an important role in inflammation by modulating neutrophil functions (By similarity). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (By similarity). To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils (PubMed:33789297). {ECO:0000250|UniProtKB:Q8CIM5, ECO:0000269|PubMed:16966319, ECO:0000269|PubMed:33789297}.
Q9NRM7 LATS2 T1041 psp Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}.
Q9P107 GMIP T418 ochoa GEM-interacting protein (GMIP) Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}.
Q9P265 DIP2B T200 ochoa Disco-interacting protein 2 homolog B (DIP2 homolog B) Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}.
Q9UJU6 DBNL T21 ochoa Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}.
Q9UK61 TASOR T1190 ochoa Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}.
Q9UKN5 PRDM4 T201 ochoa PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) May function as a transcription factor involved in cell differentiation.
Q9UKX2 MYH2 T1857 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9ULH1 ASAP1 T906 ochoa Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}.
Q9UNF0 PACSIN2 T321 ochoa Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}.
Q9UQC2 GAB2 T636 ochoa GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9UQF2 MAPK8IP1 T103 psp C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}.
Q9Y2D8 SSX2IP T307 ochoa Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}.
Q9Y2J2 EPB41L3 T703 ochoa Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.
Q9Y2K5 R3HDM2 T147 ochoa R3H domain-containing protein 2 None
Q9Y3P8 SIT1 T98 ochoa Signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein) (Suppression-inducing transmembrane adapter 1) (gp30/40) Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. {ECO:0000269|PubMed:10209036}.
Q9Y3P9 RABGAP1 T38 ochoa Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}.
Q9Y462 ZNF711 T188 ochoa Zinc finger protein 711 (Zinc finger protein 6) Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}.
Q9Y4H2 IRS2 T815 ochoa Insulin receptor substrate 2 (IRS-2) Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}.
Q9Y623 MYH4 T1855 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q96QD9 FYTTD1 T205 EPSD|PSP UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}.
P17980 PSMC3 T163 Sugiyama 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.
Q14204 DYNC1H1 T4218 Sugiyama Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}.
P07900 HSP90AA1 T65 Sugiyama Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}.
P08238 HSP90AB1 T60 Sugiyama Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
Q58FF6 HSP90AB4P T36 Sugiyama Putative heat shock protein HSP 90-beta 4 Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q58FF7 HSP90AB3P T60 Sugiyama Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q58FF8 HSP90AB2P T60 Sugiyama Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
O75390 CS T82 Sugiyama Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}.
Q9H2H8 PPIL3 T140 Sugiyama Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.
O94919 ENDOD1 T132 Sugiyama Endonuclease domain-containing 1 protein (EC 3.1.30.-) May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. {ECO:0000269|PubMed:32614325}.
P52948 NUP98 T743 Sugiyama Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.
P08253 MMP2 T377 EPSD|PSP 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
P08253 MMP2 T378 EPSD|PSP 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
O75821 EIF3G T244 Sugiyama Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.
P24752 ACAT1 T241 Sugiyama Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}.
P30044 PRDX5 T161 Sugiyama Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5) Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}.
Q15118 PDK1 T413 Sugiyama [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}.
Q15120 PDK3 T382 Sugiyama [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}.
P61758 VBP1 T48 Sugiyama Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
Q7RTN6 STRADA T38 Sugiyama STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}.
Q99832 CCT7 T385 Sugiyama T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
P80303 NUCB2 T248 Sugiyama Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}.
P07814 EPRS1 T1460 Sugiyama Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}.
O75436 VPS26A T102 Sugiyama Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}.
P43121 MCAM T104 Sugiyama Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}.
O00566 MPHOSPH10 T332 EPSD|PSP U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}.
P11279 LAMP1 T138 Sugiyama Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23632890, ECO:0000269|PubMed:23847195, ECO:0000269|PubMed:37390818, ECO:0000269|PubMed:7685349}.; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085, PubMed:25972533, PubMed:27605678, PubMed:28448640). Also promotes fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909). {ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:25972533, ECO:0000269|PubMed:27605678, ECO:0000269|PubMed:28448640, ECO:0000269|PubMed:29295909}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}.
P61221 ABCE1 T183 Sugiyama ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}.
P39023 RPL3 T189 Sugiyama Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.
Q16643 DBN1 T161 Sugiyama Drebrin (Developmentally-regulated brain protein) Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.
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reactome_id name p -log10_p
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 5.140528e-10 9.289
R-HSA-9646399 Aggrephagy 1.818824e-09 8.740
R-HSA-1640170 Cell Cycle 2.980129e-09 8.526
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 4.677349e-09 8.330
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 6.929011e-08 7.159
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.567684e-07 6.805
R-HSA-9663891 Selective autophagy 1.628430e-07 6.788
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 2.794986e-07 6.554
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 5.878367e-07 6.231
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 8.265948e-07 6.083
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 7.963323e-07 6.099
R-HSA-190872 Transport of connexons to the plasma membrane 1.066857e-06 5.972
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.396879e-06 5.855
R-HSA-2262752 Cellular responses to stress 1.210160e-06 5.917
R-HSA-9612973 Autophagy 1.329239e-06 5.876
R-HSA-389977 Post-chaperonin tubulin folding pathway 1.719282e-06 5.765
R-HSA-1169408 ISG15 antiviral mechanism 3.158360e-06 5.501
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 3.596114e-06 5.444
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 3.999848e-06 5.398
R-HSA-3371556 Cellular response to heat stress 3.905851e-06 5.408
R-HSA-68886 M Phase 4.694343e-06 5.328
R-HSA-913531 Interferon Signaling 4.861061e-06 5.313
R-HSA-8953897 Cellular responses to stimuli 5.975142e-06 5.224
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 6.936620e-06 5.159
R-HSA-9619483 Activation of AMPK downstream of NMDARs 9.805908e-06 5.009
R-HSA-69278 Cell Cycle, Mitotic 9.447778e-06 5.025
R-HSA-9609690 HCMV Early Events 1.265263e-05 4.898
R-HSA-437239 Recycling pathway of L1 1.451504e-05 4.838
R-HSA-1632852 Macroautophagy 1.670589e-05 4.777
R-HSA-9613829 Chaperone Mediated Autophagy 2.059679e-05 4.686
R-HSA-6807878 COPI-mediated anterograde transport 2.332863e-05 4.632
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 2.108565e-05 4.676
R-HSA-69473 G2/M DNA damage checkpoint 2.365851e-05 4.626
R-HSA-190861 Gap junction assembly 2.781659e-05 4.556
R-HSA-68882 Mitotic Anaphase 3.294720e-05 4.482
R-HSA-2555396 Mitotic Metaphase and Anaphase 3.438984e-05 4.464
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 3.548985e-05 4.450
R-HSA-69275 G2/M Transition 3.726776e-05 4.429
R-HSA-2980766 Nuclear Envelope Breakdown 4.158254e-05 4.381
R-HSA-453274 Mitotic G2-G2/M phases 4.087332e-05 4.389
R-HSA-5617833 Cilium Assembly 4.477763e-05 4.349
R-HSA-68877 Mitotic Prometaphase 5.123924e-05 4.290
R-HSA-168276 NS1 Mediated Effects on Host Pathways 5.238055e-05 4.281
R-HSA-422475 Axon guidance 5.120865e-05 4.291
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 5.971893e-05 4.224
R-HSA-1280215 Cytokine Signaling in Immune system 6.003551e-05 4.222
R-HSA-390466 Chaperonin-mediated protein folding 7.077049e-05 4.150
R-HSA-438064 Post NMDA receptor activation events 7.077049e-05 4.150
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 9.258390e-05 4.033
R-HSA-190828 Gap junction trafficking 1.020248e-04 3.991
R-HSA-391251 Protein folding 1.070913e-04 3.970
R-HSA-9609646 HCMV Infection 1.255845e-04 3.901
R-HSA-9675108 Nervous system development 1.232692e-04 3.909
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 1.380092e-04 3.860
R-HSA-5620920 Cargo trafficking to the periciliary membrane 1.383504e-04 3.859
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 1.354434e-04 3.868
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 1.671943e-04 3.777
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 1.610153e-04 3.793
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 1.610153e-04 3.793
R-HSA-157858 Gap junction trafficking and regulation 1.671158e-04 3.777
R-HSA-3700989 Transcriptional Regulation by TP53 1.820410e-04 3.740
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 1.896038e-04 3.722
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 1.896038e-04 3.722
R-HSA-69481 G2/M Checkpoints 1.964463e-04 3.707
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 2.134549e-04 3.671
R-HSA-1855170 IPs transport between nucleus and cytosol 2.412263e-04 3.618
R-HSA-159227 Transport of the SLBP independent Mature mRNA 2.412263e-04 3.618
R-HSA-390522 Striated Muscle Contraction 2.707294e-04 3.567
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 2.707294e-04 3.567
R-HSA-8856688 Golgi-to-ER retrograde transport 2.655085e-04 3.576
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 2.707294e-04 3.567
R-HSA-2467813 Separation of Sister Chromatids 2.728153e-04 3.564
R-HSA-9818749 Regulation of NFE2L2 gene expression 2.942021e-04 3.531
R-HSA-180746 Nuclear import of Rev protein 3.028936e-04 3.519
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 3.031649e-04 3.518
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 3.378735e-04 3.471
R-HSA-180910 Vpr-mediated nuclear import of PICs 4.169168e-04 3.380
R-HSA-983189 Kinesins 4.247206e-04 3.372
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 5.091661e-04 3.293
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 4.613069e-04 3.336
R-HSA-373760 L1CAM interactions 5.363194e-04 3.271
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 5.606657e-04 3.251
R-HSA-177243 Interactions of Rev with host cellular proteins 5.606657e-04 3.251
R-HSA-176033 Interactions of Vpr with host cellular proteins 5.606657e-04 3.251
R-HSA-199977 ER to Golgi Anterograde Transport 5.775211e-04 3.238
R-HSA-69620 Cell Cycle Checkpoints 5.978696e-04 3.223
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 6.159804e-04 3.210
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 6.763043e-04 3.170
R-HSA-2132295 MHC class II antigen presentation 7.515544e-04 3.124
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 8.354886e-04 3.078
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 9.560774e-04 3.020
R-HSA-5610787 Hedgehog 'off' state 1.031295e-03 2.987
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 1.038097e-03 2.984
R-HSA-5620924 Intraflagellar transport 1.217655e-03 2.914
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 1.558878e-03 2.807
R-HSA-9833482 PKR-mediated signaling 1.587891e-03 2.799
R-HSA-5358351 Signaling by Hedgehog 1.634067e-03 2.787
R-HSA-5693607 Processing of DNA double-strand break ends 1.680045e-03 2.775
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1.827277e-03 2.738
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 1.986929e-03 2.702
R-HSA-168255 Influenza Infection 2.017565e-03 2.695
R-HSA-111465 Apoptotic cleavage of cellular proteins 2.097276e-03 2.678
R-HSA-191859 snRNP Assembly 2.641223e-03 2.578
R-HSA-194441 Metabolism of non-coding RNA 2.641223e-03 2.578
R-HSA-9705683 SARS-CoV-2-host interactions 2.744702e-03 2.562
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 2.840697e-03 2.547
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 3.376314e-03 2.472
R-HSA-380259 Loss of Nlp from mitotic centrosomes 3.376314e-03 2.472
R-HSA-5693532 DNA Double-Strand Break Repair 2.974381e-03 2.527
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 2.998173e-03 2.523
R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.189060e-03 2.496
R-HSA-168325 Viral Messenger RNA Synthesis 2.992494e-03 2.524
R-HSA-9616222 Transcriptional regulation of granulopoiesis 3.180232e-03 2.498
R-HSA-1852241 Organelle biogenesis and maintenance 3.180907e-03 2.497
R-HSA-9707587 Regulation of HMOX1 expression and activity 3.282027e-03 2.484
R-HSA-68875 Mitotic Prophase 2.953915e-03 2.530
R-HSA-6784531 tRNA processing in the nucleus 3.180232e-03 2.498
R-HSA-8939211 ESR-mediated signaling 3.523436e-03 2.453
R-HSA-2028269 Signaling by Hippo 3.764084e-03 2.424
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 3.825920e-03 2.417
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 3.903261e-03 2.409
R-HSA-8854518 AURKA Activation by TPX2 4.016676e-03 2.396
R-HSA-948021 Transport to the Golgi and subsequent modification 4.137589e-03 2.383
R-HSA-5693606 DNA Double Strand Break Response 4.248186e-03 2.372
R-HSA-8953854 Metabolism of RNA 4.384627e-03 2.358
R-HSA-5578749 Transcriptional regulation by small RNAs 5.550310e-03 2.256
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 5.629699e-03 2.250
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 5.841057e-03 2.234
R-HSA-380287 Centrosome maturation 6.454460e-03 2.190
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 7.103100e-03 2.149
R-HSA-9018519 Estrogen-dependent gene expression 6.005261e-03 2.221
R-HSA-75153 Apoptotic execution phase 7.205399e-03 2.142
R-HSA-211000 Gene Silencing by RNA 6.831968e-03 2.165
R-HSA-189200 Cellular hexose transport 7.302733e-03 2.137
R-HSA-9006931 Signaling by Nuclear Receptors 7.941294e-03 2.100
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 8.610879e-03 2.065
R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 8.790540e-03 2.056
R-HSA-8951430 RUNX3 regulates WNT signaling 8.790540e-03 2.056
R-HSA-5336415 Uptake and function of diphtheria toxin 8.790540e-03 2.056
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 8.895913e-03 2.051
R-HSA-1266738 Developmental Biology 9.028066e-03 2.044
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 9.779289e-03 2.010
R-HSA-168256 Immune System 9.905568e-03 2.004
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 1.003855e-02 1.998
R-HSA-1500620 Meiosis 1.020945e-02 1.991
R-HSA-5339562 Uptake and actions of bacterial toxins 1.030196e-02 1.987
R-HSA-446107 Type I hemidesmosome assembly 1.054038e-02 1.977
R-HSA-72163 mRNA Splicing - Major Pathway 1.057755e-02 1.976
R-HSA-74160 Gene expression (Transcription) 1.076424e-02 1.968
R-HSA-1221632 Meiotic synapsis 1.088965e-02 1.963
R-HSA-5693538 Homology Directed Repair 1.099176e-02 1.959
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 1.110837e-02 1.954
R-HSA-9709570 Impaired BRCA2 binding to RAD51 1.329163e-02 1.876
R-HSA-72172 mRNA Splicing 1.393330e-02 1.856
R-HSA-1227990 Signaling by ERBB2 in Cancer 1.431916e-02 1.844
R-HSA-8863795 Downregulation of ERBB2 signaling 1.431916e-02 1.844
R-HSA-9834752 Respiratory syncytial virus genome replication 1.243062e-02 1.906
R-HSA-162909 Host Interactions of HIV factors 1.341542e-02 1.872
R-HSA-8851680 Butyrophilin (BTN) family interactions 1.243062e-02 1.906
R-HSA-109581 Apoptosis 1.375033e-02 1.862
R-HSA-5357801 Programmed Cell Death 1.427284e-02 1.845
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 1.445711e-02 1.840
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 1.487034e-02 1.828
R-HSA-182971 EGFR downregulation 1.539054e-02 1.813
R-HSA-5619102 SLC transporter disorders 1.573370e-02 1.803
R-HSA-9832991 Formation of the posterior neural plate 1.661573e-02 1.779
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 1.766565e-02 1.753
R-HSA-9824446 Viral Infection Pathways 1.788996e-02 1.747
R-HSA-69615 G1/S DNA Damage Checkpoints 1.797432e-02 1.745
R-HSA-5693548 Sensing of DNA Double Strand Breaks 1.890249e-02 1.723
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 2.011810e-02 1.696
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 2.011810e-02 1.696
R-HSA-70171 Glycolysis 2.029823e-02 1.693
R-HSA-9711123 Cellular response to chemical stress 2.048075e-02 1.689
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 2.131348e-02 1.671
R-HSA-4641265 Repression of WNT target genes 2.131348e-02 1.671
R-HSA-8983711 OAS antiviral response 2.131348e-02 1.671
R-HSA-5685942 HDR through Homologous Recombination (HRR) 2.145355e-02 1.669
R-HSA-162582 Signal Transduction 2.213651e-02 1.655
R-HSA-3371511 HSF1 activation 2.274852e-02 1.643
R-HSA-6804757 Regulation of TP53 Degradation 2.274852e-02 1.643
R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 2.743915e-02 1.562
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 2.743915e-02 1.562
R-HSA-9673013 Diseases of Telomere Maintenance 2.743915e-02 1.562
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 2.743915e-02 1.562
R-HSA-5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) 2.743915e-02 1.562
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 2.743915e-02 1.562
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 2.743915e-02 1.562
R-HSA-9708530 Regulation of BACH1 activity 3.212411e-02 1.493
R-HSA-9755511 KEAP1-NFE2L2 pathway 3.199871e-02 1.495
R-HSA-174430 Telomere C-strand synthesis initiation 2.925380e-02 1.534
R-HSA-5218920 VEGFR2 mediated vascular permeability 3.010287e-02 1.521
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 2.925380e-02 1.534
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 3.010287e-02 1.521
R-HSA-69541 Stabilization of p53 2.702798e-02 1.568
R-HSA-399954 Sema3A PAK dependent Axon repulsion 2.925380e-02 1.534
R-HSA-165159 MTOR signalling 3.335426e-02 1.477
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 2.925380e-02 1.534
R-HSA-9924644 Developmental Lineages of the Mammary Gland 2.634576e-02 1.579
R-HSA-9823739 Formation of the anterior neural plate 2.925380e-02 1.534
R-HSA-6806003 Regulation of TP53 Expression and Degradation 2.702798e-02 1.568
R-HSA-9679191 Potential therapeutics for SARS 3.122489e-02 1.505
R-HSA-1483249 Inositol phosphate metabolism 3.064733e-02 1.514
R-HSA-1643685 Disease 3.234295e-02 1.490
R-HSA-9679506 SARS-CoV Infections 3.188111e-02 1.496
R-HSA-5619115 Disorders of transmembrane transporters 3.461246e-02 1.461
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... 3.510026e-02 1.455
R-HSA-9694516 SARS-CoV-2 Infection 3.512229e-02 1.454
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 3.678082e-02 1.434
R-HSA-70326 Glucose metabolism 3.737882e-02 1.427
R-HSA-5637812 Signaling by EGFRvIII in Cancer 3.817880e-02 1.418
R-HSA-5637810 Constitutive Signaling by EGFRvIII 3.817880e-02 1.418
R-HSA-5210891 Uptake and function of anthrax toxins 3.817880e-02 1.418
R-HSA-2219528 PI3K/AKT Signaling in Cancer 3.840874e-02 1.416
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 3.855928e-02 1.414
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 3.855928e-02 1.414
R-HSA-5633007 Regulation of TP53 Activity 3.952811e-02 1.403
R-HSA-9675135 Diseases of DNA repair 4.038088e-02 1.394
R-HSA-9915355 Beta-ketothiolase deficiency 4.087632e-02 1.389
R-HSA-5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG... 4.087632e-02 1.389
R-HSA-5609974 Defective PGM1 causes PGM1-CDG 4.087632e-02 1.389
R-HSA-5619101 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG... 4.087632e-02 1.389
R-HSA-352238 Breakdown of the nuclear lamina 4.087632e-02 1.389
R-HSA-9665348 Signaling by ERBB2 ECD mutants 4.135637e-02 1.383
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 4.135637e-02 1.383
R-HSA-4419969 Depolymerization of the Nuclear Lamina 4.135637e-02 1.383
R-HSA-6804760 Regulation of TP53 Activity through Methylation 4.135637e-02 1.383
R-HSA-9759194 Nuclear events mediated by NFE2L2 4.160203e-02 1.381
R-HSA-6794362 Protein-protein interactions at synapses 4.197747e-02 1.377
R-HSA-5687128 MAPK6/MAPK4 signaling 4.197747e-02 1.377
R-HSA-112316 Neuronal System 4.233743e-02 1.373
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 4.415244e-02 1.355
R-HSA-9709603 Impaired BRCA2 binding to PALB2 4.462966e-02 1.350
R-HSA-844456 The NLRP3 inflammasome 4.462966e-02 1.350
R-HSA-9734767 Developmental Cell Lineages 4.591603e-02 1.338
R-HSA-69563 p53-Dependent G1 DNA Damage Response 4.610183e-02 1.336
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 4.610183e-02 1.336
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 5.412865e-02 1.267
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 5.412865e-02 1.267
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 5.412865e-02 1.267
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 5.412865e-02 1.267
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 5.412865e-02 1.267
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 5.412865e-02 1.267
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 5.412865e-02 1.267
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 5.412865e-02 1.267
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 5.412865e-02 1.267
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 5.412865e-02 1.267
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 5.412865e-02 1.267
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 6.719869e-02 1.173
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 4.799546e-02 1.319
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 4.799546e-02 1.319
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 4.799546e-02 1.319
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 4.799546e-02 1.319
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 5.145060e-02 1.289
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 5.145060e-02 1.289
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 6.610394e-02 1.180
R-HSA-429947 Deadenylation of mRNA 6.610394e-02 1.180
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 6.996086e-02 1.155
R-HSA-177929 Signaling by EGFR 6.090416e-02 1.215
R-HSA-174411 Polymerase switching on the C-strand of the telomere 6.996086e-02 1.155
R-HSA-112399 IRS-mediated signalling 6.317957e-02 1.199
R-HSA-1227986 Signaling by ERBB2 7.023799e-02 1.153
R-HSA-109704 PI3K Cascade 4.809322e-02 1.318
R-HSA-8876384 Listeria monocytogenes entry into host cells 5.499201e-02 1.260
R-HSA-166208 mTORC1-mediated signalling 5.861666e-02 1.232
R-HSA-3371571 HSF1-dependent transactivation 5.012628e-02 1.300
R-HSA-2682334 EPH-Ephrin signaling 5.529663e-02 1.257
R-HSA-74182 Ketone body metabolism 6.232160e-02 1.205
R-HSA-6794361 Neurexins and neuroligins 5.220067e-02 1.282
R-HSA-77111 Synthesis of Ketone Bodies 4.799546e-02 1.319
R-HSA-199991 Membrane Trafficking 4.849020e-02 1.314
R-HSA-1474165 Reproduction 5.465220e-02 1.262
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 6.232160e-02 1.205
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 5.499201e-02 1.260
R-HSA-196836 Vitamin C (ascorbate) metabolism 5.145060e-02 1.289
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 6.610394e-02 1.180
R-HSA-8863678 Neurodegenerative Diseases 6.610394e-02 1.180
R-HSA-112315 Transmission across Chemical Synapses 5.222676e-02 1.282
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 5.550248e-02 1.256
R-HSA-72306 tRNA processing 5.014811e-02 1.300
R-HSA-212436 Generic Transcription Pathway 7.231669e-02 1.141
R-HSA-9009391 Extra-nuclear estrogen signaling 7.245900e-02 1.140
R-HSA-2428928 IRS-related events triggered by IGF1R 7.266672e-02 1.139
R-HSA-1643713 Signaling by EGFR in Cancer 7.388960e-02 1.131
R-HSA-9615933 Postmitotic nuclear pore complex (NPC) reformation 7.388960e-02 1.131
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 7.388960e-02 1.131
R-HSA-162599 Late Phase of HIV Life Cycle 7.432245e-02 1.129
R-HSA-5663205 Infectious disease 7.740653e-02 1.111
R-HSA-373755 Semaphorin interactions 7.763534e-02 1.110
R-HSA-3928663 EPHA-mediated growth cone collapse 7.788745e-02 1.109
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 7.788745e-02 1.109
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 7.807977e-02 1.107
R-HSA-73857 RNA Polymerase II Transcription 7.878017e-02 1.104
R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 8.008892e-02 1.096
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 8.008892e-02 1.096
R-HSA-1251932 PLCG1 events in ERBB2 signaling 8.008892e-02 1.096
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 8.008892e-02 1.096
R-HSA-205025 NADE modulates death signalling 8.008892e-02 1.096
R-HSA-74751 Insulin receptor signalling cascade 8.017428e-02 1.096
R-HSA-2428924 IGF1R signaling cascade 8.017428e-02 1.096
R-HSA-622312 Inflammasomes 8.195179e-02 1.086
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 8.274899e-02 1.082
R-HSA-73894 DNA Repair 8.588681e-02 1.066
R-HSA-9615710 Late endosomal microautophagy 8.608002e-02 1.065
R-HSA-9664565 Signaling by ERBB2 KD Mutants 8.608002e-02 1.065
R-HSA-9759475 Regulation of CDH11 Expression and Function 8.608002e-02 1.065
R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 8.608002e-02 1.065
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 8.791631e-02 1.056
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 8.791631e-02 1.056
R-HSA-1250196 SHC1 events in ERBB2 signaling 9.026963e-02 1.044
R-HSA-9008059 Interleukin-37 signaling 9.026963e-02 1.044
R-HSA-9818025 NFE2L2 regulating TCA cycle genes 9.280180e-02 1.032
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 9.280180e-02 1.032
R-HSA-74713 IRS activation 9.280180e-02 1.032
R-HSA-165158 Activation of AKT2 9.280180e-02 1.032
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 9.280180e-02 1.032
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 9.280180e-02 1.032
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 9.280180e-02 1.032
R-HSA-8866376 Reelin signalling pathway 9.280180e-02 1.032
R-HSA-9833576 CDH11 homotypic and heterotypic interactions 1.053398e-01 0.977
R-HSA-5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 1.053398e-01 0.977
R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR 1.053398e-01 0.977
R-HSA-8857538 PTK6 promotes HIF1A stabilization 1.177052e-01 0.929
R-HSA-9027283 Erythropoietin activates STAT5 1.177052e-01 0.929
R-HSA-9645135 STAT5 Activation 1.177052e-01 0.929
R-HSA-112412 SOS-mediated signalling 1.299005e-01 0.886
R-HSA-212718 EGFR interacts with phospholipase C-gamma 1.419280e-01 0.848
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 1.537899e-01 0.813
R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 1.537899e-01 0.813
R-HSA-201688 WNT mediated activation of DVL 1.537899e-01 0.813
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 1.654886e-01 0.781
R-HSA-390450 Folding of actin by CCT/TriC 1.654886e-01 0.781
R-HSA-68952 DNA replication initiation 1.654886e-01 0.781
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 1.884051e-01 0.725
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 1.257117e-01 0.901
R-HSA-9670095 Inhibition of DNA recombination at telomere 1.397397e-01 0.855
R-HSA-141424 Amplification of signal from the kinetochores 1.441670e-01 0.841
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 1.441670e-01 0.841
R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 1.638840e-01 0.785
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.672460e-01 0.777
R-HSA-72689 Formation of a pool of free 40S subunits 1.843482e-01 0.734
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 1.075934e-01 0.968
R-HSA-9948299 Ribosome-associated quality control 1.712963e-01 0.766
R-HSA-6798695 Neutrophil degranulation 1.325553e-01 0.878
R-HSA-9664873 Pexophagy 1.654886e-01 0.781
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 1.843482e-01 0.734
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 1.492713e-01 0.826
R-HSA-9762292 Regulation of CDH11 function 1.654886e-01 0.781
R-HSA-198203 PI3K/AKT activation 1.654886e-01 0.781
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 1.770263e-01 0.752
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 1.785686e-01 0.748
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 1.211153e-01 0.917
R-HSA-72737 Cap-dependent Translation Initiation 1.092727e-01 0.961
R-HSA-4641258 Degradation of DVL 1.257117e-01 0.901
R-HSA-72613 Eukaryotic Translation Initiation 1.092727e-01 0.961
R-HSA-2025928 Calcineurin activates NFAT 1.537899e-01 0.813
R-HSA-5610780 Degradation of GLI1 by the proteasome 1.492713e-01 0.826
R-HSA-5693537 Resolution of D-Loop Structures 1.075934e-01 0.968
R-HSA-8937144 Aryl hydrocarbon receptor signalling 1.053398e-01 0.977
R-HSA-169911 Regulation of Apoptosis 1.165620e-01 0.933
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 1.031823e-01 0.986
R-HSA-4608870 Asymmetric localization of PCP proteins 1.686994e-01 0.773
R-HSA-176187 Activation of ATR in response to replication stress 1.031823e-01 0.986
R-HSA-8856828 Clathrin-mediated endocytosis 1.877204e-01 0.726
R-HSA-2470946 Cohesin Loading onto Chromatin 1.299005e-01 0.886
R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis 1.537899e-01 0.813
R-HSA-2179392 EGFR Transactivation by Gastrin 1.654886e-01 0.781
R-HSA-192905 vRNP Assembly 1.770263e-01 0.752
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 1.774510e-01 0.751
R-HSA-1839124 FGFR1 mutant receptor activation 1.031823e-01 0.986
R-HSA-74749 Signal attenuation 1.654886e-01 0.781
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.120540e-01 0.951
R-HSA-5655302 Signaling by FGFR1 in disease 1.492713e-01 0.826
R-HSA-9764260 Regulation of Expression and Function of Type II Classical Cadherins 1.031823e-01 0.986
R-HSA-74752 Signaling by Insulin receptor 1.706282e-01 0.768
R-HSA-5653890 Lactose synthesis 1.177052e-01 0.929
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 1.654886e-01 0.781
R-HSA-77108 Utilization of Ketone Bodies 1.770263e-01 0.752
R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 1.884051e-01 0.725
R-HSA-3858494 Beta-catenin independent WNT signaling 1.659387e-01 0.780
R-HSA-9766229 Degradation of CDH1 1.885241e-01 0.725
R-HSA-4420097 VEGFA-VEGFR2 Pathway 1.070399e-01 0.970
R-HSA-114608 Platelet degranulation 1.376328e-01 0.861
R-HSA-194138 Signaling by VEGF 1.327134e-01 0.877
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 1.736224e-01 0.760
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 1.736224e-01 0.760
R-HSA-444257 RSK activation 1.419280e-01 0.848
R-HSA-68884 Mitotic Telophase/Cytokinesis 1.884051e-01 0.725
R-HSA-9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 1.350259e-01 0.870
R-HSA-195253 Degradation of beta-catenin by the destruction complex 9.614177e-02 1.017
R-HSA-9762293 Regulation of CDH11 gene transcription 1.537899e-01 0.813
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 1.554113e-01 0.809
R-HSA-446728 Cell junction organization 1.244171e-01 0.905
R-HSA-8853659 RET signaling 1.211153e-01 0.917
R-HSA-9764302 Regulation of CDH19 Expression and Function 1.053398e-01 0.977
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 1.419280e-01 0.848
R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle 1.397397e-01 0.855
R-HSA-3371568 Attenuation phase 1.397397e-01 0.855
R-HSA-9837999 Mitochondrial protein degradation 1.774510e-01 0.751
R-HSA-5653656 Vesicle-mediated transport 1.178620e-01 0.929
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 1.757029e-01 0.755
R-HSA-5632684 Hedgehog 'on' state 9.892060e-02 1.005
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 1.654886e-01 0.781
R-HSA-3928662 EPHB-mediated forward signaling 1.638011e-01 0.786
R-HSA-1280218 Adaptive Immune System 1.621009e-01 0.790
R-HSA-1433557 Signaling by SCF-KIT 1.589292e-01 0.799
R-HSA-69206 G1/S Transition 1.327134e-01 0.877
R-HSA-430116 GP1b-IX-V activation signalling 1.537899e-01 0.813
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 1.885241e-01 0.725
R-HSA-5607764 CLEC7A (Dectin-1) signaling 1.878233e-01 0.726
R-HSA-2586552 Signaling by Leptin 1.654886e-01 0.781
R-HSA-9610379 HCMV Late Events 9.912294e-02 1.004
R-HSA-1980143 Signaling by NOTCH1 1.132873e-01 0.946
R-HSA-9861718 Regulation of pyruvate metabolism 1.736224e-01 0.760
R-HSA-9707564 Cytoprotection by HMOX1 1.346256e-01 0.871
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 1.257117e-01 0.901
R-HSA-9645723 Diseases of programmed cell death 1.539248e-01 0.813
R-HSA-9764790 Positive Regulation of CDH1 Gene Transcription 1.654886e-01 0.781
R-HSA-69205 G1/S-Specific Transcription 1.211153e-01 0.917
R-HSA-446203 Asparagine N-linked glycosylation 1.671637e-01 0.777
R-HSA-162906 HIV Infection 1.324702e-01 0.878
R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer 1.835363e-01 0.736
R-HSA-449147 Signaling by Interleukins 1.187351e-01 0.925
R-HSA-162587 HIV Life Cycle 9.912294e-02 1.004
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 1.350259e-01 0.870
R-HSA-1500931 Cell-Cell communication 1.899520e-01 0.721
R-HSA-157579 Telomere Maintenance 1.913154e-01 0.718
R-HSA-8878159 Transcriptional regulation by RUNX3 1.913154e-01 0.718
R-HSA-453279 Mitotic G1 phase and G1/S transition 1.961173e-01 0.707
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1.996274e-01 0.700
R-HSA-69109 Leading Strand Synthesis 1.996274e-01 0.700
R-HSA-69091 Polymerase switching 1.996274e-01 0.700
R-HSA-9820865 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 1.996274e-01 0.700
R-HSA-3000484 Scavenging by Class F Receptors 1.996274e-01 0.700
R-HSA-179812 GRB2 events in EGFR signaling 1.996274e-01 0.700
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 1.996274e-01 0.700
R-HSA-8983432 Interleukin-15 signaling 1.996274e-01 0.700
R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 1.996274e-01 0.700
R-HSA-198323 AKT phosphorylates targets in the cytosol 1.996274e-01 0.700
R-HSA-69618 Mitotic Spindle Checkpoint 2.018883e-01 0.695
R-HSA-72187 mRNA 3'-end processing 2.035928e-01 0.691
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 2.106951e-01 0.676
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 2.132457e-01 0.671
R-HSA-72649 Translation initiation complex formation 2.137124e-01 0.670
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 2.161918e-01 0.665
R-HSA-69166 Removal of the Flap Intermediate 2.216105e-01 0.654
R-HSA-8847993 ERBB2 Activates PTK6 Signaling 2.216105e-01 0.654
R-HSA-9764562 Regulation of CDH1 mRNA translation by microRNAs 2.216105e-01 0.654
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 2.216105e-01 0.654
R-HSA-397014 Muscle contraction 2.232399e-01 0.651
R-HSA-72702 Ribosomal scanning and start codon recognition 2.238784e-01 0.650
R-HSA-3299685 Detoxification of Reactive Oxygen Species 2.238784e-01 0.650
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 2.238784e-01 0.650
R-HSA-9692914 SARS-CoV-1-host interactions 2.270561e-01 0.644
R-HSA-9764561 Regulation of CDH1 Function 2.289757e-01 0.640
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 2.307010e-01 0.637
R-HSA-9700206 Signaling by ALK in cancer 2.307010e-01 0.637
R-HSA-9711097 Cellular response to starvation 2.307735e-01 0.637
R-HSA-9027284 Erythropoietin activates RAS 2.323755e-01 0.634
R-HSA-180336 SHC1 events in EGFR signaling 2.323755e-01 0.634
R-HSA-6785631 ERBB2 Regulates Cell Motility 2.323755e-01 0.634
R-HSA-69183 Processive synthesis on the lagging strand 2.323755e-01 0.634
R-HSA-111447 Activation of BAD and translocation to mitochondria 2.323755e-01 0.634
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 2.323755e-01 0.634
R-HSA-446353 Cell-extracellular matrix interactions 2.323755e-01 0.634
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 2.340809e-01 0.631
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 2.340809e-01 0.631
R-HSA-180786 Extension of Telomeres 2.391927e-01 0.621
R-HSA-429914 Deadenylation-dependent mRNA decay 2.391927e-01 0.621
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 2.391927e-01 0.621
R-HSA-9006925 Intracellular signaling by second messengers 2.414079e-01 0.617
R-HSA-5099900 WNT5A-dependent internalization of FZD4 2.429924e-01 0.614
R-HSA-9673324 WNT5:FZD7-mediated leishmania damping 2.429924e-01 0.614
R-HSA-9664420 Killing mechanisms 2.429924e-01 0.614
R-HSA-5635838 Activation of SMO 2.429924e-01 0.614
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 2.429924e-01 0.614
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 2.443101e-01 0.612
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 2.443101e-01 0.612
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 2.443101e-01 0.612
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 2.443101e-01 0.612
R-HSA-2644603 Signaling by NOTCH1 in Cancer 2.443101e-01 0.612
R-HSA-5362517 Signaling by Retinoic Acid 2.443101e-01 0.612
R-HSA-927802 Nonsense-Mediated Decay (NMD) 2.490788e-01 0.604
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 2.490788e-01 0.604
R-HSA-73856 RNA Polymerase II Transcription Termination 2.494319e-01 0.603
R-HSA-1963640 GRB2 events in ERBB2 signaling 2.534630e-01 0.596
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 2.534630e-01 0.596
R-HSA-432047 Passive transport by Aquaporins 2.534630e-01 0.596
R-HSA-70370 Galactose catabolism 2.534630e-01 0.596
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 2.545570e-01 0.594
R-HSA-9707616 Heme signaling 2.545570e-01 0.594
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 2.637895e-01 0.579
R-HSA-1963642 PI3K events in ERBB2 signaling 2.637895e-01 0.579
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 2.648129e-01 0.577
R-HSA-180292 GAB1 signalosome 2.739737e-01 0.562
R-HSA-73980 RNA Polymerase III Transcription Termination 2.739737e-01 0.562
R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 2.739737e-01 0.562
R-HSA-8849932 Synaptic adhesion-like molecules 2.739737e-01 0.562
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 2.750697e-01 0.561
R-HSA-1257604 PIP3 activates AKT signaling 2.759813e-01 0.559
R-HSA-9764265 Regulation of CDH1 Expression and Function 2.790444e-01 0.554
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 2.790444e-01 0.554
R-HSA-195721 Signaling by WNT 2.830797e-01 0.548
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 2.840177e-01 0.547
R-HSA-113510 E2F mediated regulation of DNA replication 2.840177e-01 0.547
R-HSA-1480926 O2/CO2 exchange in erythrocytes 2.840177e-01 0.547
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 2.840177e-01 0.547
R-HSA-73886 Chromosome Maintenance 2.901794e-01 0.537
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 2.904398e-01 0.537
R-HSA-72766 Translation 2.909621e-01 0.536
R-HSA-5620916 VxPx cargo-targeting to cilium 2.939234e-01 0.532
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 2.939234e-01 0.532
R-HSA-6807004 Negative regulation of MET activity 2.939234e-01 0.532
R-HSA-71288 Creatine metabolism 2.939234e-01 0.532
R-HSA-445144 Signal transduction by L1 2.939234e-01 0.532
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 2.939234e-01 0.532
R-HSA-3322077 Glycogen synthesis 2.939234e-01 0.532
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 2.955555e-01 0.529
R-HSA-69202 Cyclin E associated events during G1/S transition 2.955555e-01 0.529
R-HSA-157118 Signaling by NOTCH 2.961565e-01 0.528
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 2.977166e-01 0.526
R-HSA-9816359 Maternal to zygotic transition (MZT) 2.977166e-01 0.526
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 3.006658e-01 0.522
R-HSA-2559583 Cellular Senescence 3.006676e-01 0.522
R-HSA-69186 Lagging Strand Synthesis 3.036926e-01 0.518
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 3.057701e-01 0.515
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 3.057701e-01 0.515
R-HSA-201681 TCF dependent signaling in response to WNT 3.099973e-01 0.509
R-HSA-4086398 Ca2+ pathway 3.108675e-01 0.507
R-HSA-1226099 Signaling by FGFR in disease 3.159572e-01 0.500
R-HSA-71403 Citric acid cycle (TCA cycle) 3.210384e-01 0.493
R-HSA-6803529 FGFR2 alternative splicing 3.228291e-01 0.491
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 3.228291e-01 0.491
R-HSA-3238698 WNT ligand biogenesis and trafficking 3.228291e-01 0.491
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 3.228291e-01 0.491
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 3.228291e-01 0.491
R-HSA-8964038 LDL clearance 3.228291e-01 0.491
R-HSA-199418 Negative regulation of the PI3K/AKT network 3.279481e-01 0.484
R-HSA-912526 Interleukin receptor SHC signaling 3.322001e-01 0.479
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 3.322001e-01 0.479
R-HSA-392451 G beta:gamma signalling through PI3Kgamma 3.322001e-01 0.479
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 3.322001e-01 0.479
R-HSA-3000170 Syndecan interactions 3.322001e-01 0.479
R-HSA-982772 Growth hormone receptor signaling 3.322001e-01 0.479
R-HSA-4086400 PCP/CE pathway 3.362242e-01 0.473
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 3.414420e-01 0.467
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 3.442118e-01 0.463
R-HSA-400685 Sema4D in semaphorin signaling 3.505566e-01 0.455
R-HSA-1482801 Acyl chain remodelling of PS 3.505566e-01 0.455
R-HSA-5218921 VEGFR2 mediated cell proliferation 3.505566e-01 0.455
R-HSA-3000157 Laminin interactions 3.505566e-01 0.455
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 3.505566e-01 0.455
R-HSA-70221 Glycogen breakdown (glycogenolysis) 3.505566e-01 0.455
R-HSA-1266695 Interleukin-7 signaling 3.505566e-01 0.455
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 3.506777e-01 0.455
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 3.563114e-01 0.448
R-HSA-525793 Myogenesis 3.595456e-01 0.444
R-HSA-9703465 Signaling by FLT3 fusion proteins 3.595456e-01 0.444
R-HSA-5689901 Metalloprotease DUBs 3.595456e-01 0.444
R-HSA-3295583 TRP channels 3.595456e-01 0.444
R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 3.595456e-01 0.444
R-HSA-9865118 Diseases of branched-chain amino acid catabolism 3.595456e-01 0.444
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 3.619355e-01 0.441
R-HSA-174414 Processive synthesis on the C-strand of the telomere 3.684107e-01 0.434
R-HSA-171306 Packaging Of Telomere Ends 3.684107e-01 0.434
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 3.684107e-01 0.434
R-HSA-389357 CD28 dependent PI3K/Akt signaling 3.684107e-01 0.434
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 3.684107e-01 0.434
R-HSA-381119 Unfolded Protein Response (UPR) 3.694607e-01 0.432
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 3.726362e-01 0.429
R-HSA-376176 Signaling by ROBO receptors 3.726362e-01 0.429
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 3.769703e-01 0.424
R-HSA-171319 Telomere Extension By Telomerase 3.771536e-01 0.423
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 3.771536e-01 0.423
R-HSA-381038 XBP1(S) activates chaperone genes 3.811073e-01 0.419
R-HSA-9006335 Signaling by Erythropoietin 3.857760e-01 0.414
R-HSA-1592389 Activation of Matrix Metalloproteinases 3.857760e-01 0.414
R-HSA-9674555 Signaling by CSF3 (G-CSF) 3.857760e-01 0.414
R-HSA-70268 Pyruvate metabolism 3.860193e-01 0.413
R-HSA-76002 Platelet activation, signaling and aggregation 3.888329e-01 0.410
R-HSA-156902 Peptide chain elongation 3.909143e-01 0.408
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 3.942796e-01 0.404
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 3.942796e-01 0.404
R-HSA-68962 Activation of the pre-replicative complex 3.942796e-01 0.404
R-HSA-114452 Activation of BH3-only proteins 3.942796e-01 0.404
R-HSA-202424 Downstream TCR signaling 4.006516e-01 0.397
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 4.026660e-01 0.395
R-HSA-9820960 Respiratory syncytial virus (RSV) attachment and entry 4.026660e-01 0.395
R-HSA-5683057 MAPK family signaling cascades 4.026865e-01 0.395
R-HSA-8986944 Transcriptional Regulation by MECP2 4.054931e-01 0.392
R-HSA-69242 S Phase 4.068053e-01 0.391
R-HSA-381070 IRE1alpha activates chaperones 4.103159e-01 0.387
R-HSA-9758941 Gastrulation 4.105072e-01 0.387
R-HSA-69190 DNA strand elongation 4.109368e-01 0.386
R-HSA-9675126 Diseases of mitotic cell cycle 4.109368e-01 0.386
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 4.109368e-01 0.386
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected ... 4.109368e-01 0.386
R-HSA-1538133 G0 and Early G1 4.109368e-01 0.386
R-HSA-156842 Eukaryotic Translation Elongation 4.151195e-01 0.382
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 4.190936e-01 0.378
R-HSA-5675482 Regulation of necroptotic cell death 4.190936e-01 0.378
R-HSA-397795 G-protein beta:gamma signalling 4.190936e-01 0.378
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis 4.190936e-01 0.378
R-HSA-354192 Integrin signaling 4.190936e-01 0.378
R-HSA-446652 Interleukin-1 family signaling 4.215699e-01 0.375
R-HSA-418990 Adherens junctions interactions 4.225302e-01 0.374
R-HSA-1474290 Collagen formation 4.246679e-01 0.372
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 4.271379e-01 0.369
R-HSA-1482788 Acyl chain remodelling of PC 4.271379e-01 0.369
R-HSA-180534 Vpu mediated degradation of CD4 4.271379e-01 0.369
R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... 4.294118e-01 0.367
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 4.294118e-01 0.367
R-HSA-72764 Eukaryotic Translation Termination 4.341352e-01 0.362
R-HSA-9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 4.350713e-01 0.361
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 4.350713e-01 0.361
R-HSA-203615 eNOS activation 4.350713e-01 0.361
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 4.350713e-01 0.361
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 4.350713e-01 0.361
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected ... 4.350713e-01 0.361
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 4.388377e-01 0.358
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 4.388377e-01 0.358
R-HSA-392499 Metabolism of proteins 4.397730e-01 0.357
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 4.428954e-01 0.354
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 4.428954e-01 0.354
R-HSA-1482839 Acyl chain remodelling of PE 4.428954e-01 0.354
R-HSA-381042 PERK regulates gene expression 4.428954e-01 0.354
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 4.434799e-01 0.353
R-HSA-170834 Signaling by TGF-beta Receptor Complex 4.435188e-01 0.353
R-HSA-9682385 FLT3 signaling in disease 4.506115e-01 0.346
R-HSA-180585 Vif-mediated degradation of APOBEC3G 4.506115e-01 0.346
R-HSA-114604 GPVI-mediated activation cascade 4.506115e-01 0.346
R-HSA-111933 Calmodulin induced events 4.506115e-01 0.346
R-HSA-111997 CaM pathway 4.506115e-01 0.346
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 4.506115e-01 0.346
R-HSA-74158 RNA Polymerase III Transcription 4.506115e-01 0.346
R-HSA-193704 p75 NTR receptor-mediated signalling 4.528161e-01 0.344
R-HSA-4641257 Degradation of AXIN 4.582213e-01 0.339
R-HSA-110331 Cleavage of the damaged purine 4.582213e-01 0.339
R-HSA-2408557 Selenocysteine synthesis 4.620248e-01 0.335
R-HSA-2408522 Selenoamino acid metabolism 4.650626e-01 0.332
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 4.657261e-01 0.332
R-HSA-73927 Depurination 4.657261e-01 0.332
R-HSA-452723 Transcriptional regulation of pluripotent stem cells 4.657261e-01 0.332
R-HSA-5213460 RIPK1-mediated regulated necrosis 4.657261e-01 0.332
R-HSA-192823 Viral mRNA Translation 4.711427e-01 0.327
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 4.731274e-01 0.325
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 4.731274e-01 0.325
R-HSA-8953750 Transcriptional Regulation by E2F6 4.731274e-01 0.325
R-HSA-71336 Pentose phosphate pathway 4.731274e-01 0.325
R-HSA-201556 Signaling by ALK 4.731274e-01 0.325
R-HSA-8964043 Plasma lipoprotein clearance 4.731274e-01 0.325
R-HSA-9604323 Negative regulation of NOTCH4 signaling 4.804266e-01 0.318
R-HSA-8941858 Regulation of RUNX3 expression and activity 4.804266e-01 0.318
R-HSA-451927 Interleukin-2 family signaling 4.804266e-01 0.318
R-HSA-8982491 Glycogen metabolism 4.804266e-01 0.318
R-HSA-9607240 FLT3 Signaling 4.876252e-01 0.312
R-HSA-5362768 Hh mutants are degraded by ERAD 4.876252e-01 0.312
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 4.876252e-01 0.312
R-HSA-8853884 Transcriptional Regulation by VENTX 4.876252e-01 0.312
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 4.876252e-01 0.312
R-HSA-3214841 PKMTs methylate histone lysines 4.876252e-01 0.312
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 4.897707e-01 0.310
R-HSA-5621481 C-type lectin receptors (CLRs) 4.932556e-01 0.307
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 4.935278e-01 0.307
R-HSA-69239 Synthesis of DNA 4.935278e-01 0.307
R-HSA-9932298 Degradation of CRY and PER proteins 4.947244e-01 0.306
R-HSA-5610783 Degradation of GLI2 by the proteasome 4.947244e-01 0.306
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 4.947244e-01 0.306
R-HSA-442660 SLC-mediated transport of neurotransmitters 4.947244e-01 0.306
R-HSA-9909648 Regulation of PD-L1(CD274) expression 4.967289e-01 0.304
R-HSA-379716 Cytosolic tRNA aminoacylation 5.017257e-01 0.300
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 5.017257e-01 0.300
R-HSA-111996 Ca-dependent events 5.017257e-01 0.300
R-HSA-110329 Cleavage of the damaged pyrimidine 5.017257e-01 0.300
R-HSA-73928 Depyrimidination 5.017257e-01 0.300
R-HSA-69002 DNA Replication Pre-Initiation 5.023136e-01 0.299
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 5.036396e-01 0.298
R-HSA-202403 TCR signaling 5.066698e-01 0.295
R-HSA-9678108 SARS-CoV-1 Infection 5.070769e-01 0.295
R-HSA-9710421 Defective pyroptosis 5.086305e-01 0.294
R-HSA-5387390 Hh mutants abrogate ligand secretion 5.086305e-01 0.294
R-HSA-8854214 TBC/RABGAPs 5.086305e-01 0.294
R-HSA-9824439 Bacterial Infection Pathways 5.094497e-01 0.293
R-HSA-9907900 Proteasome assembly 5.154399e-01 0.288
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 5.154399e-01 0.288
R-HSA-421270 Cell-cell junction organization 5.216485e-01 0.283
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 5.221555e-01 0.282
R-HSA-6783310 Fanconi Anemia Pathway 5.221555e-01 0.282
R-HSA-5678895 Defective CFTR causes cystic fibrosis 5.221555e-01 0.282
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 5.221555e-01 0.282
R-HSA-1489509 DAG and IP3 signaling 5.221555e-01 0.282
R-HSA-9824272 Somitogenesis 5.221555e-01 0.282
R-HSA-76009 Platelet Aggregation (Plug Formation) 5.221555e-01 0.282
R-HSA-72165 mRNA Splicing - Minor Pathway 5.287783e-01 0.277
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 5.287783e-01 0.277
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 5.287783e-01 0.277
R-HSA-5628897 TP53 Regulates Metabolic Genes 5.322821e-01 0.274
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 5.353098e-01 0.271
R-HSA-388841 Regulation of T cell activation by CD28 family 5.359914e-01 0.271
R-HSA-389356 Co-stimulation by CD28 5.417512e-01 0.266
R-HSA-9007101 Rab regulation of trafficking 5.447456e-01 0.264
R-HSA-8868773 rRNA processing in the nucleus and cytosol 5.505953e-01 0.259
R-HSA-5658442 Regulation of RAS by GAPs 5.543684e-01 0.256
R-HSA-912446 Meiotic recombination 5.605467e-01 0.251
R-HSA-1169091 Activation of NF-kappaB in B cells 5.605467e-01 0.251
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 5.605467e-01 0.251
R-HSA-5358346 Hedgehog ligand biogenesis 5.605467e-01 0.251
R-HSA-70895 Branched-chain amino acid catabolism 5.605467e-01 0.251
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 5.666397e-01 0.247
R-HSA-68949 Orc1 removal from chromatin 5.666397e-01 0.247
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 5.666397e-01 0.247
R-HSA-9692916 SARS-CoV-1 activates/modulates innate immune responses 5.666397e-01 0.247
R-HSA-109582 Hemostasis 5.671257e-01 0.246
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 5.726487e-01 0.242
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 5.726487e-01 0.242
R-HSA-8948751 Regulation of PTEN stability and activity 5.726487e-01 0.242
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 5.785746e-01 0.238
R-HSA-73929 Base-Excision Repair, AP Site Formation 5.785746e-01 0.238
R-HSA-3214815 HDACs deacetylate histones 5.844188e-01 0.233
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 5.844188e-01 0.233
R-HSA-9012852 Signaling by NOTCH3 5.844188e-01 0.233
R-HSA-389948 Co-inhibition by PD-1 5.887029e-01 0.230
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 5.901823e-01 0.229
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 5.901823e-01 0.229
R-HSA-109606 Intrinsic Pathway for Apoptosis 5.901823e-01 0.229
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 5.958661e-01 0.225
R-HSA-9824443 Parasitic Infection Pathways 6.042766e-01 0.219
R-HSA-9658195 Leishmania infection 6.042766e-01 0.219
R-HSA-352230 Amino acid transport across the plasma membrane 6.069996e-01 0.217
R-HSA-9843745 Adipogenesis 6.072617e-01 0.217
R-HSA-379724 tRNA Aminoacylation 6.124512e-01 0.213
R-HSA-351202 Metabolism of polyamines 6.124512e-01 0.213
R-HSA-9764725 Negative Regulation of CDH1 Gene Transcription 6.124512e-01 0.213
R-HSA-1442490 Collagen degradation 6.178276e-01 0.209
R-HSA-445717 Aquaporin-mediated transport 6.178276e-01 0.209
R-HSA-8939902 Regulation of RUNX2 expression and activity 6.178276e-01 0.209
R-HSA-112043 PLC beta mediated events 6.178276e-01 0.209
R-HSA-9793380 Formation of paraxial mesoderm 6.178276e-01 0.209
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 6.231297e-01 0.205
R-HSA-1268020 Mitochondrial protein import 6.231297e-01 0.205
R-HSA-186797 Signaling by PDGF 6.231297e-01 0.205
R-HSA-8848021 Signaling by PTK6 6.283586e-01 0.202
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 6.283586e-01 0.202
R-HSA-6790901 rRNA modification in the nucleus and cytosol 6.283586e-01 0.202
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 6.386006e-01 0.195
R-HSA-1234174 Cellular response to hypoxia 6.386006e-01 0.195
R-HSA-6782315 tRNA modification in the nucleus and cytosol 6.436158e-01 0.191
R-HSA-112040 G-protein mediated events 6.485617e-01 0.188
R-HSA-9958863 SLC-mediated transport of amino acids 6.485617e-01 0.188
R-HSA-597592 Post-translational protein modification 6.495528e-01 0.187
R-HSA-8951664 Neddylation 6.529976e-01 0.185
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 6.534392e-01 0.185
R-HSA-5218859 Regulated Necrosis 6.534392e-01 0.185
R-HSA-2871837 FCERI mediated NF-kB activation 6.597796e-01 0.181
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 6.629930e-01 0.178
R-HSA-9764560 Regulation of CDH1 Gene Transcription 6.629930e-01 0.178
R-HSA-427413 NoRC negatively regulates rRNA expression 6.676711e-01 0.175
R-HSA-453276 Regulation of mitotic cell cycle 6.676711e-01 0.175
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 6.676711e-01 0.175
R-HSA-8978934 Metabolism of cofactors 6.676711e-01 0.175
R-HSA-69052 Switching of origins to a post-replicative state 6.768343e-01 0.170
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 6.768343e-01 0.170
R-HSA-9013694 Signaling by NOTCH4 6.813211e-01 0.167
R-HSA-1236394 Signaling by ERBB4 6.813211e-01 0.167
R-HSA-72312 rRNA processing 6.823471e-01 0.166
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 6.854196e-01 0.164
R-HSA-3000171 Non-integrin membrane-ECM interactions 6.857459e-01 0.164
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 6.857459e-01 0.164
R-HSA-69306 DNA Replication 6.885112e-01 0.162
R-HSA-5689603 UCH proteinases 6.901095e-01 0.161
R-HSA-73887 Death Receptor Signaling 6.915779e-01 0.160
R-HSA-416482 G alpha (12/13) signalling events 6.986566e-01 0.156
R-HSA-5619084 ABC transporter disorders 6.986566e-01 0.156
R-HSA-9659379 Sensory processing of sound 7.028417e-01 0.153
R-HSA-877300 Interferon gamma signaling 7.065415e-01 0.151
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 7.069690e-01 0.151
R-HSA-5654738 Signaling by FGFR2 7.069690e-01 0.151
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 7.069690e-01 0.151
R-HSA-6806834 Signaling by MET 7.069690e-01 0.151
R-HSA-9006936 Signaling by TGFB family members 7.094609e-01 0.149
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 7.190114e-01 0.143
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 7.229151e-01 0.141
R-HSA-6802957 Oncogenic MAPK signaling 7.267647e-01 0.139
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 7.305611e-01 0.136
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 7.305611e-01 0.136
R-HSA-5688426 Deubiquitination 7.376834e-01 0.132
R-HSA-1428517 Aerobic respiration and respiratory electron transport 7.411899e-01 0.130
R-HSA-418555 G alpha (s) signalling events 7.426384e-01 0.129
R-HSA-1236974 ER-Phagosome pathway 7.452288e-01 0.128
R-HSA-5689880 Ub-specific processing proteases 7.478431e-01 0.126
R-HSA-73884 Base Excision Repair 7.487697e-01 0.126
R-HSA-112310 Neurotransmitter release cycle 7.487697e-01 0.126
R-HSA-373080 Class B/2 (Secretin family receptors) 7.487697e-01 0.126
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 7.591013e-01 0.120
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... 7.624503e-01 0.118
R-HSA-68867 Assembly of the pre-replicative complex 7.624503e-01 0.118
R-HSA-5389840 Mitochondrial translation elongation 7.753890e-01 0.110
R-HSA-5368286 Mitochondrial translation initiation 7.815928e-01 0.107
R-HSA-422356 Regulation of insulin secretion 7.815928e-01 0.107
R-HSA-190236 Signaling by FGFR 7.815928e-01 0.107
R-HSA-168249 Innate Immune System 7.817701e-01 0.107
R-HSA-9614085 FOXO-mediated transcription 7.846304e-01 0.105
R-HSA-382556 ABC-family proteins mediated transport 7.876260e-01 0.104
R-HSA-9020702 Interleukin-1 signaling 7.905801e-01 0.102
R-HSA-9842860 Regulation of endogenous retroelements 7.934932e-01 0.100
R-HSA-9937383 Mitochondrial ribosome-associated quality control 7.963661e-01 0.099
R-HSA-9860931 Response of endothelial cells to shear stress 7.991991e-01 0.097
R-HSA-111885 Opioid Signalling 7.991991e-01 0.097
R-HSA-5673001 RAF/MAP kinase cascade 8.052238e-01 0.094
R-HSA-1236975 Antigen processing-Cross presentation 8.127864e-01 0.090
R-HSA-2672351 Stimuli-sensing channels 8.127864e-01 0.090
R-HSA-5419276 Mitochondrial translation termination 8.153919e-01 0.089
R-HSA-5684996 MAPK1/MAPK3 signaling 8.171657e-01 0.088
R-HSA-9855142 Cellular responses to mechanical stimuli 8.278880e-01 0.082
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 8.302843e-01 0.081
R-HSA-2871809 FCERI mediated Ca+2 mobilization 8.349777e-01 0.078
R-HSA-909733 Interferon alpha/beta signaling 8.349777e-01 0.078
R-HSA-425407 SLC-mediated transmembrane transport 8.350693e-01 0.078
R-HSA-9730414 MITF-M-regulated melanocyte development 8.361533e-01 0.078
R-HSA-8878166 Transcriptional regulation by RUNX2 8.439802e-01 0.074
R-HSA-8878171 Transcriptional regulation by RUNX1 8.577059e-01 0.067
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 8.622988e-01 0.064
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 8.637995e-01 0.064
R-HSA-187037 Signaling by NTRK1 (TRKA) 8.644046e-01 0.063
R-HSA-1474244 Extracellular matrix organization 8.679557e-01 0.062
R-HSA-3247509 Chromatin modifying enzymes 8.696541e-01 0.061
R-HSA-1474228 Degradation of the extracellular matrix 8.735952e-01 0.059
R-HSA-9909396 Circadian clock 8.735952e-01 0.059
R-HSA-163685 Integration of energy metabolism 8.821655e-01 0.054
R-HSA-71291 Metabolism of amino acids and derivatives 8.823594e-01 0.054
R-HSA-5368287 Mitochondrial translation 8.854294e-01 0.053
R-HSA-6807070 PTEN Regulation 8.870274e-01 0.052
R-HSA-9664422 FCGR3A-mediated phagocytosis 8.886032e-01 0.051
R-HSA-9664417 Leishmania phagocytosis 8.886032e-01 0.051
R-HSA-9664407 Parasite infection 8.886032e-01 0.051
R-HSA-4839726 Chromatin organization 8.896128e-01 0.051
R-HSA-166520 Signaling by NTRKs 9.018364e-01 0.045
R-HSA-196854 Metabolism of vitamins and cofactors 9.040576e-01 0.044
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 9.045576e-01 0.044
R-HSA-416476 G alpha (q) signalling events 9.067147e-01 0.043
R-HSA-9609507 Protein localization 9.084992e-01 0.042
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 9.239745e-01 0.034
R-HSA-388396 GPCR downstream signalling 9.287935e-01 0.032
R-HSA-3781865 Diseases of glycosylation 9.416778e-01 0.026
R-HSA-983712 Ion channel transport 9.456452e-01 0.024
R-HSA-212165 Epigenetic regulation of gene expression 9.527407e-01 0.021
R-HSA-1483206 Glycerophospholipid biosynthesis 9.553814e-01 0.020
R-HSA-372790 Signaling by GPCR 9.631864e-01 0.016
R-HSA-382551 Transport of small molecules 9.711179e-01 0.013
R-HSA-983169 Class I MHC mediated antigen processing & presentation 9.771737e-01 0.010
R-HSA-418594 G alpha (i) signalling events 9.829541e-01 0.007
R-HSA-211945 Phase I - Functionalization of compounds 9.847649e-01 0.007
R-HSA-5668914 Diseases of metabolism 9.866649e-01 0.006
R-HSA-1483257 Phospholipid metabolism 9.880284e-01 0.005
R-HSA-211859 Biological oxidations 9.995463e-01 0.000
R-HSA-500792 GPCR ligand binding 9.998249e-01 0.000
R-HSA-1430728 Metabolism 9.999999e-01 0.000
R-HSA-556833 Metabolism of lipids 9.999999e-01 0.000
R-HSA-9709957 Sensory Perception 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GAKGAK 0.863 0.071 1 0.818
PKRPKR 0.852 0.074 1 0.804
ALK4ALK4 0.850 0.207 -2 0.885
TAK1TAK1 0.850 -0.027 1 0.811
PASKPASK 0.848 0.185 -3 0.830
DAPK2DAPK2 0.848 0.145 -3 0.859
GCKGCK 0.847 0.018 1 0.775
EEF2KEEF2K 0.847 0.036 3 0.756
VRK2VRK2 0.846 -0.222 1 0.844
NIKNIK 0.845 0.092 -3 0.876
LRRK2LRRK2 0.845 -0.077 2 0.826
ALK2ALK2 0.845 0.210 -2 0.860
TGFBR1TGFBR1 0.844 0.254 -2 0.860
DMPK1DMPK1 0.844 0.183 -3 0.764
LATS1LATS1 0.844 0.171 -3 0.846
TNIKTNIK 0.844 -0.015 3 0.772
BRAFBRAF 0.843 -0.034 -4 0.782
CAMLCKCAMLCK 0.843 0.124 -2 0.894
VRK1VRK1 0.842 -0.178 2 0.771
DAPK3DAPK3 0.842 0.151 -3 0.793
MEK1MEK1 0.842 -0.078 2 0.780
MOSMOS 0.841 0.181 1 0.909
BMPR2BMPR2 0.841 -0.052 -2 0.883
MST1MST1 0.841 -0.052 1 0.755
TAO2TAO2 0.841 -0.040 2 0.840
MST3MST3 0.841 0.088 2 0.838
BMPR1BBMPR1B 0.841 0.260 1 0.896
NEK1NEK1 0.840 -0.072 1 0.753
MINKMINK 0.839 -0.081 1 0.739
KHS2KHS2 0.839 0.036 1 0.738
KHS1KHS1 0.839 -0.012 1 0.713
TAO3TAO3 0.839 0.007 1 0.775
TTKTTK 0.838 -0.031 -2 0.841
CAMK1BCAMK1B 0.838 0.118 -3 0.856
HPK1HPK1 0.838 0.009 1 0.742
MST2MST2 0.837 -0.081 1 0.782
ASK1ASK1 0.837 -0.167 1 0.734
ROCK2ROCK2 0.837 0.169 -3 0.783
HGKHGK 0.836 -0.057 3 0.773
ACVR2BACVR2B 0.836 0.186 -2 0.843
SMMLCKSMMLCK 0.835 0.092 -3 0.811
CAMKK2CAMKK2 0.835 -0.085 -2 0.722
LKB1LKB1 0.834 -0.074 -3 0.821
DAPK1DAPK1 0.834 0.156 -3 0.770
NEK5NEK5 0.834 -0.084 1 0.786
DLKDLK 0.834 -0.067 1 0.857
PRPKPRPK 0.834 -0.060 -1 0.827
MEK5MEK5 0.833 -0.242 2 0.779
ACVR2AACVR2A 0.833 0.166 -2 0.837
OSR1OSR1 0.833 -0.084 2 0.782
ALPHAK3ALPHAK3 0.833 -0.081 -1 0.776
PDK1PDK1 0.833 -0.116 1 0.756
BIKEBIKE 0.832 -0.026 1 0.670
ANKRD3ANKRD3 0.832 -0.057 1 0.829
YSK1YSK1 0.832 -0.028 2 0.819
MEKK2MEKK2 0.832 -0.161 2 0.769
MAP3K15MAP3K15 0.832 -0.144 1 0.739
GRK7GRK7 0.831 0.184 1 0.832
NEK8NEK8 0.831 -0.080 2 0.800
ATRATR 0.830 0.047 1 0.831
CAMKK1CAMKK1 0.830 -0.142 -2 0.713
BMPR1ABMPR1A 0.830 0.225 1 0.884
MYO3BMYO3B 0.829 -0.057 2 0.832
SKMLCKSKMLCK 0.828 0.147 -2 0.901
MEKK6MEKK6 0.828 -0.143 1 0.752
MYO3AMYO3A 0.828 -0.095 1 0.721
CDKL1CDKL1 0.828 0.042 -3 0.787
NEK4NEK4 0.827 -0.121 1 0.729
GRK6GRK6 0.827 0.143 1 0.904
MEKK1MEKK1 0.826 -0.168 1 0.780
PBKPBK 0.826 -0.040 1 0.707
NLKNLK 0.826 0.007 1 0.787
YSK4YSK4 0.826 -0.071 1 0.745
LOKLOK 0.826 0.012 -2 0.771
PIM1PIM1 0.825 0.173 -3 0.771
CAMK2GCAMK2G 0.825 0.120 2 0.786
CLK3CLK3 0.825 0.249 1 0.816
MEK2MEK2 0.825 -0.218 2 0.754
NEK11NEK11 0.825 -0.162 1 0.767
MPSK1MPSK1 0.825 -0.034 1 0.726
MRCKAMRCKA 0.825 0.181 -3 0.754
ICKICK 0.824 0.035 -3 0.819
ZAKZAK 0.823 -0.120 1 0.777
MEKK3MEKK3 0.822 -0.159 1 0.788
ROCK1ROCK1 0.822 0.136 -3 0.754
PLK1PLK1 0.821 0.051 -2 0.810
STLK3STLK3 0.821 -0.239 1 0.736
PIM3PIM3 0.821 0.158 -3 0.820
GRK5GRK5 0.821 0.032 -3 0.836
CDC7CDC7 0.820 0.213 1 0.914
RAF1RAF1 0.820 -0.056 1 0.821
P70S6KBP70S6KB 0.820 0.155 -3 0.794
PERKPERK 0.819 -0.069 -2 0.845
COTCOT 0.819 0.145 2 0.821
AAK1AAK1 0.819 0.002 1 0.549
GSK3BGSK3B 0.818 0.202 4 0.616
WNK1WNK1 0.818 0.117 -2 0.877
PIM2PIM2 0.818 0.129 -3 0.741
MST4MST4 0.817 0.160 2 0.877
PKN3PKN3 0.817 0.078 -3 0.812
PKCDPKCD 0.817 0.143 2 0.797
SLKSLK 0.817 0.009 -2 0.714
CRIKCRIK 0.817 0.125 -3 0.695
HRIHRI 0.817 -0.111 -2 0.863
DRAK1DRAK1 0.817 0.102 1 0.862
MRCKBMRCKB 0.817 0.145 -3 0.738
GSK3AGSK3A 0.817 0.217 4 0.624
JNK2JNK2 0.816 0.001 1 0.566
RSK2RSK2 0.816 0.219 -3 0.768
DCAMKL1DCAMKL1 0.816 0.067 -3 0.789
JNK3JNK3 0.816 -0.020 1 0.605
TLK2TLK2 0.815 -0.035 1 0.776
MLK2MLK2 0.814 -0.142 2 0.801
CHAK2CHAK2 0.814 0.044 -1 0.855
TLK1TLK1 0.813 -0.055 -2 0.852
MLK1MLK1 0.812 -0.063 2 0.808
NEK2NEK2 0.812 -0.002 2 0.813
AMPKA1AMPKA1 0.812 0.049 -3 0.848
PKN2PKN2 0.812 0.109 -3 0.838
NEK9NEK9 0.812 -0.099 2 0.823
GRK2GRK2 0.812 0.053 -2 0.737
TAO1TAO1 0.812 -0.103 1 0.672
SGK3SGK3 0.811 0.134 -3 0.758
MYLK4MYLK4 0.811 0.130 -2 0.845
PDHK4PDHK4 0.811 -0.193 1 0.831
CAMK2ACAMK2A 0.811 0.207 2 0.784
DSTYKDSTYK 0.811 0.052 2 0.852
P38AP38A 0.810 -0.040 1 0.632
WNK4WNK4 0.810 -0.101 -2 0.858
CAMK2BCAMK2B 0.810 0.177 2 0.754
BUB1BUB1 0.810 0.059 -5 0.769
PRP4PRP4 0.809 -0.078 -3 0.737
CLK4CLK4 0.809 0.140 -3 0.760
DCAMKL2DCAMKL2 0.809 0.030 -3 0.815
TSSK2TSSK2 0.809 -0.014 -5 0.815
ERK5ERK5 0.808 -0.047 1 0.737
RSK4RSK4 0.808 0.220 -3 0.733
CAMK2DCAMK2D 0.808 0.086 -3 0.832
PLK3PLK3 0.808 0.020 2 0.694
TGFBR2TGFBR2 0.807 0.090 -2 0.853
RIPK3RIPK3 0.806 -0.037 3 0.685
P38BP38B 0.806 -0.026 1 0.571
RIPK1RIPK1 0.806 -0.150 1 0.782
CHK1CHK1 0.806 -0.022 -3 0.828
AKT2AKT2 0.806 0.111 -3 0.682
MASTLMASTL 0.806 -0.276 -2 0.791
SGK1SGK1 0.806 0.121 -3 0.601
MLK3MLK3 0.806 0.012 2 0.761
HIPK1HIPK1 0.805 0.025 1 0.649
NUAK2NUAK2 0.805 0.025 -3 0.832
CDKL5CDKL5 0.805 0.035 -3 0.777
P90RSKP90RSK 0.805 0.123 -3 0.762
GRK1GRK1 0.805 0.148 -2 0.777
PKCAPKCA 0.805 0.132 2 0.757
PDHK1PDHK1 0.805 -0.218 1 0.803
DNAPKDNAPK 0.804 0.048 1 0.655
HASPINHASPIN 0.804 -0.045 -1 0.651
IRAK4IRAK4 0.804 -0.106 1 0.740
ATMATM 0.803 0.031 1 0.777
AURBAURB 0.803 0.178 -2 0.769
MLK4MLK4 0.803 -0.046 2 0.727
ERK7ERK7 0.803 0.105 2 0.648
MTORMTOR 0.802 -0.039 1 0.752
MSK1MSK1 0.802 0.169 -3 0.735
PAK1PAK1 0.802 0.107 -2 0.845
PKCHPKCH 0.801 0.087 2 0.727
CHAK1CHAK1 0.801 -0.073 2 0.753
AMPKA2AMPKA2 0.801 0.043 -3 0.821
TSSK1TSSK1 0.801 0.020 -3 0.866
MARK4MARK4 0.800 -0.011 4 0.838
MAKMAK 0.800 0.048 -2 0.759
CAMK4CAMK4 0.800 0.034 -3 0.818
NDR1NDR1 0.800 0.113 -3 0.831
CAMK1DCAMK1D 0.800 0.060 -3 0.678
NEK7NEK7 0.799 -0.054 -3 0.840
HUNKHUNK 0.799 -0.130 2 0.723
CDK1CDK1 0.799 0.014 1 0.608
SMG1SMG1 0.798 0.001 1 0.769
PKACGPKACG 0.798 0.178 -2 0.832
AKT1AKT1 0.798 0.122 -3 0.704
CLK1CLK1 0.798 0.135 -3 0.747
NEK6NEK6 0.798 0.032 -2 0.857
CK2A2CK2A2 0.798 0.252 1 0.868
PAK2PAK2 0.797 0.037 -2 0.828
PLK2PLK2 0.797 0.047 -3 0.783
PKCBPKCB 0.797 0.100 2 0.756
NEK3NEK3 0.797 -0.184 1 0.694
P38GP38G 0.797 -0.027 1 0.504
WNK3WNK3 0.796 -0.150 1 0.779
PKCEPKCE 0.796 0.132 2 0.742
JNK1JNK1 0.796 -0.030 1 0.579
RSK3RSK3 0.796 0.135 -3 0.759
ERK2ERK2 0.796 -0.072 1 0.604
PKCZPKCZ 0.796 0.046 2 0.781
MOKMOK 0.796 0.012 1 0.643
CLK2CLK2 0.796 0.199 -3 0.742
CDK5CDK5 0.796 -0.016 1 0.646
ULK2ULK2 0.795 -0.117 2 0.743
PINK1PINK1 0.795 -0.191 1 0.774
PKACBPKACB 0.795 0.208 -2 0.788
PKG2PKG2 0.795 0.170 -2 0.792
AURCAURC 0.795 0.227 -2 0.775
PKCGPKCG 0.795 0.094 2 0.750
MNK1MNK1 0.794 0.156 -2 0.864
AURAAURA 0.794 0.152 -2 0.741
SRPK3SRPK3 0.794 0.027 -3 0.705
SRPK1SRPK1 0.793 0.070 -3 0.735
CAMK1GCAMK1G 0.793 0.036 -3 0.756
CDK14CDK14 0.793 0.007 1 0.597
NDR2NDR2 0.793 0.165 -3 0.831
MAPKAPK3MAPKAPK3 0.792 0.021 -3 0.772
MELKMELK 0.792 -0.011 -3 0.809
IRE2IRE2 0.792 -0.060 2 0.727
DYRK2DYRK2 0.792 -0.020 1 0.634
CHK2CHK2 0.792 0.006 -3 0.635
LATS2LATS2 0.791 0.103 -5 0.775
PAK3PAK3 0.791 0.049 -2 0.833
GRK4GRK4 0.791 -0.060 -2 0.826
CDK2CDK2 0.790 -0.041 1 0.713
IRE1IRE1 0.790 -0.086 1 0.741
HIPK4HIPK4 0.790 0.014 1 0.727
CK2A1CK2A1 0.789 0.238 1 0.856
DYRK1ADYRK1A 0.789 -0.026 1 0.677
PKCIPKCI 0.789 0.087 2 0.765
MSK2MSK2 0.789 0.075 -3 0.722
TTBK2TTBK2 0.789 -0.157 2 0.660
P70S6KP70S6K 0.789 0.080 -3 0.704
PRKD3PRKD3 0.788 0.040 -3 0.744
TBK1TBK1 0.788 -0.182 1 0.690
ERK1ERK1 0.788 -0.042 1 0.550
P38DP38D 0.788 -0.035 1 0.495
HIPK3HIPK3 0.787 -0.043 1 0.624
CDK10CDK10 0.787 0.069 1 0.581
PDHK3_TYRPDHK3_TYR 0.787 0.321 4 0.899
MNK2MNK2 0.787 0.129 -2 0.853
MAPKAPK2MAPKAPK2 0.787 0.097 -3 0.728
PRKD1PRKD1 0.786 0.063 -3 0.815
PRKXPRKX 0.786 0.267 -3 0.680
QIKQIK 0.786 -0.066 -3 0.828
PRKD2PRKD2 0.786 0.126 -3 0.770
SSTKSSTK 0.785 0.005 4 0.795
CDK16CDK16 0.785 0.024 1 0.533
PKACAPKACA 0.785 0.176 -2 0.754
GRK3GRK3 0.785 0.038 -2 0.702
MARK2MARK2 0.784 -0.026 4 0.747
CDK6CDK6 0.784 -0.035 1 0.561
QSKQSK 0.783 0.004 4 0.812
CAMK1ACAMK1A 0.783 0.039 -3 0.658
PKCTPKCT 0.783 0.037 2 0.736
DYRK3DYRK3 0.783 0.017 1 0.645
DYRK1BDYRK1B 0.783 -0.019 1 0.590
MARK3MARK3 0.783 0.017 4 0.783
CDK4CDK4 0.782 -0.041 1 0.553
STK33STK33 0.782 -0.116 2 0.565
IKKBIKKB 0.782 -0.111 -2 0.725
GCN2GCN2 0.782 -0.077 2 0.780
MARK1MARK1 0.782 -0.033 4 0.794
RIPK2RIPK2 0.782 -0.252 1 0.718
CDK3CDK3 0.781 -0.001 1 0.534
IRAK1IRAK1 0.781 -0.319 -1 0.698
AKT3AKT3 0.780 0.117 -3 0.616
CDK17CDK17 0.780 -0.022 1 0.517
IKKEIKKE 0.780 -0.205 1 0.680
ULK1ULK1 0.780 -0.137 -3 0.807
NIM1NIM1 0.779 -0.093 3 0.696
HIPK2HIPK2 0.779 0.025 1 0.540
SRPK2SRPK2 0.779 0.076 -3 0.660
SBKSBK 0.778 0.012 -3 0.568
CDK18CDK18 0.778 -0.003 1 0.556
PDHK4_TYRPDHK4_TYR 0.778 0.139 2 0.828
IKKAIKKA 0.777 -0.037 -2 0.709
CDK7CDK7 0.777 -0.044 1 0.625
CDK13CDK13 0.777 -0.060 1 0.591
SIKSIK 0.776 0.008 -3 0.761
TESK1_TYRTESK1_TYR 0.776 0.048 3 0.800
DYRK4DYRK4 0.775 -0.006 1 0.566
NUAK1NUAK1 0.775 -0.026 -3 0.790
CDK8CDK8 0.774 -0.057 1 0.622
MAP2K4_TYRMAP2K4_TYR 0.774 0.034 -1 0.844
CDK9CDK9 0.774 -0.059 1 0.592
BMPR2_TYRBMPR2_TYR 0.774 0.067 -1 0.833
PHKG1PHKG1 0.773 -0.006 -3 0.821
CDK12CDK12 0.773 -0.062 1 0.561
MAP2K6_TYRMAP2K6_TYR 0.773 0.043 -1 0.845
PDHK1_TYRPDHK1_TYR 0.772 0.043 -1 0.865
PLK4PLK4 0.771 -0.166 2 0.542
BCKDKBCKDK 0.771 -0.196 -1 0.742
PKMYT1_TYRPKMYT1_TYR 0.768 -0.077 3 0.770
MAP2K7_TYRMAP2K7_TYR 0.768 -0.140 2 0.805
PAK6PAK6 0.768 0.119 -2 0.771
CK1DCK1D 0.768 -0.050 -3 0.443
EPHA6EPHA6 0.768 0.050 -1 0.836
PKN1PKN1 0.767 0.020 -3 0.722
PINK1_TYRPINK1_TYR 0.767 -0.108 1 0.840
BRSK1BRSK1 0.766 -0.016 -3 0.787
LIMK2_TYRLIMK2_TYR 0.766 0.008 -3 0.891
YANK3YANK3 0.765 -0.058 2 0.362
CK1A2CK1A2 0.765 -0.038 -3 0.442
TTBK1TTBK1 0.765 -0.158 2 0.573
FAM20CFAM20C 0.763 0.032 2 0.540
MAPKAPK5MAPKAPK5 0.763 -0.098 -3 0.705
SNRKSNRK 0.762 -0.177 2 0.614
EPHB4EPHB4 0.761 -0.024 -1 0.819
BRSK2BRSK2 0.761 -0.076 -3 0.813
TXKTXK 0.761 0.091 1 0.934
CK1ECK1E 0.760 -0.041 -3 0.496
PHKG2PHKG2 0.759 0.001 -3 0.809
LIMK1_TYRLIMK1_TYR 0.758 -0.164 2 0.815
CDK19CDK19 0.758 -0.061 1 0.577
RETRET 0.757 -0.158 1 0.774
DDR1DDR1 0.756 -0.115 4 0.827
EPHA4EPHA4 0.756 -0.013 2 0.698
FGRFGR 0.755 -0.107 1 0.864
YES1YES1 0.754 -0.080 -1 0.816
SRMSSRMS 0.754 -0.043 1 0.905
FERFER 0.753 -0.122 1 0.907
YANK2YANK2 0.753 -0.092 2 0.380
MST1RMST1R 0.753 -0.195 3 0.710
PAK5PAK5 0.752 0.063 -2 0.717
ROS1ROS1 0.752 -0.183 3 0.671
EPHB1EPHB1 0.752 -0.060 1 0.880
TYRO3TYRO3 0.751 -0.198 3 0.695
TYK2TYK2 0.751 -0.266 1 0.761
ABL2ABL2 0.750 -0.095 -1 0.795
TNK2TNK2 0.750 -0.072 3 0.674
INSRRINSRR 0.749 -0.115 3 0.666
JAK3JAK3 0.748 -0.162 1 0.775
EPHB2EPHB2 0.748 -0.061 -1 0.800
FGFR2FGFR2 0.748 -0.137 3 0.730
ABL1ABL1 0.748 -0.103 -1 0.786
CSF1RCSF1R 0.747 -0.202 3 0.688
EPHB3EPHB3 0.747 -0.099 -1 0.798
JAK2JAK2 0.747 -0.261 1 0.758
KDRKDR 0.747 -0.107 3 0.665
BLKBLK 0.747 -0.035 -1 0.804
ITKITK 0.746 -0.098 -1 0.760
HCKHCK 0.746 -0.146 -1 0.791
LCKLCK 0.746 -0.085 -1 0.793
TNNI3K_TYRTNNI3K_TYR 0.745 -0.056 1 0.773
PDGFRBPDGFRB 0.744 -0.191 3 0.700
TECTEC 0.744 -0.062 -1 0.719
BMXBMX 0.744 -0.057 -1 0.709
EPHA7EPHA7 0.744 -0.055 2 0.700
FLT1FLT1 0.743 -0.078 -1 0.816
MERTKMERTK 0.743 -0.104 3 0.685
AXLAXL 0.742 -0.145 3 0.690
KISKIS 0.742 -0.035 1 0.631
PKG1PKG1 0.742 0.069 -2 0.726
PAK4PAK4 0.742 0.066 -2 0.727
EPHA3EPHA3 0.741 -0.105 2 0.674
FYNFYN 0.741 -0.057 -1 0.766
NEK10_TYRNEK10_TYR 0.741 -0.127 1 0.620
KITKIT 0.741 -0.202 3 0.694
METMET 0.741 -0.152 3 0.683
JAK1JAK1 0.740 -0.123 1 0.696
WEE1_TYRWEE1_TYR 0.740 -0.107 -1 0.719
FGFR1FGFR1 0.739 -0.214 3 0.680
DDR2DDR2 0.739 -0.040 3 0.663
PTK2BPTK2B 0.739 -0.039 -1 0.745
TNK1TNK1 0.738 -0.150 3 0.676
LTKLTK 0.738 -0.152 3 0.644
NTRK1NTRK1 0.738 -0.185 -1 0.786
FLT3FLT3 0.738 -0.229 3 0.687
EPHA5EPHA5 0.737 -0.055 2 0.671
EGFREGFR 0.737 -0.045 1 0.739
ALKALK 0.737 -0.180 3 0.618
FGFR3FGFR3 0.737 -0.155 3 0.700
ERBB2ERBB2 0.736 -0.163 1 0.797
PTK2PTK2 0.736 0.019 -1 0.756
PTK6PTK6 0.736 -0.214 -1 0.700
TEKTEK 0.736 -0.234 3 0.644
FLT4FLT4 0.735 -0.171 3 0.680
PDGFRAPDGFRA 0.735 -0.270 3 0.698
SYKSYK 0.735 0.009 -1 0.756
EPHA8EPHA8 0.734 -0.086 -1 0.784
EPHA1EPHA1 0.733 -0.156 3 0.658
BTKBTK 0.733 -0.241 -1 0.727
NTRK2NTRK2 0.733 -0.214 3 0.672
FRKFRK 0.733 -0.140 -1 0.812
MATKMATK 0.733 -0.126 -1 0.738
NTRK3NTRK3 0.733 -0.150 -1 0.745
LYNLYN 0.730 -0.177 3 0.627
INSRINSR 0.729 -0.213 3 0.639
SRCSRC 0.729 -0.132 -1 0.774
CSKCSK 0.727 -0.164 2 0.705
EPHA2EPHA2 0.725 -0.078 -1 0.762
FGFR4FGFR4 0.725 -0.126 -1 0.768
ERBB4ERBB4 0.723 -0.048 1 0.781
CK1G1CK1G1 0.723 -0.102 -3 0.494
MUSKMUSK 0.721 -0.118 1 0.701
IGF1RIGF1R 0.717 -0.176 3 0.586
CK1G3CK1G3 0.717 -0.095 -3 0.304
FESFES 0.707 -0.151 -1 0.685
CK1G2CK1G2 0.704 -0.068 -3 0.405
ZAP70ZAP70 0.702 -0.084 -1 0.683
CK1ACK1A 0.700 -0.048 -3 0.353