Motif 1073 (n=187)
Position-wise Probabilities
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uniprot | genes | site | source | protein | function |
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A1A4S6 | ARHGAP10 | T633 | ochoa | Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) | GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes (PubMed:11432776). Also converts Cdc42 to an inactive GDP-bound state (PubMed:11432776). Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (PubMed:32344433). {ECO:0000250|UniProtKB:Q6Y5D8, ECO:0000269|PubMed:11432776, ECO:0000269|PubMed:32344433}. |
A6NKT7 | RGPD3 | T1500 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
O14641 | DVL2 | T206 | psp | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
O14757 | CHEK1 | T330 | ochoa | Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12399544, PubMed:12446774, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15650047, PubMed:15665856). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14559997, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:12676583, PubMed:12676925, PubMed:12759351, PubMed:14681206, PubMed:19734889, PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:19734889, PubMed:20090422, PubMed:9278511). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}. |
O14867 | BACH1 | T360 | ochoa | Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) | Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}. |
O43164 | PJA2 | T279 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
O43399 | TPD52L2 | T163 | ochoa | Tumor protein D54 (hD54) (Tumor protein D52-like 2) | None |
O60315 | ZEB2 | T1117 | ochoa | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212). {ECO:0000269|PubMed:16061479, ECO:0000269|PubMed:20516212}. |
O60716 | CTNND1 | T932 | ochoa | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:20371349}. |
O75116 | ROCK2 | T1214 | ochoa | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
O75369 | FLNB | T2110 | ochoa | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro. |
O75717 | WDHD1 | T310 | ochoa | WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) | Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork. {ECO:0000269|PubMed:19805216, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:35585232}. |
O75937 | DNAJC8 | T47 | ochoa | DnaJ homolog subfamily C member 8 (Splicing protein spf31) | Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}. |
O95049 | TJP3 | T588 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
O95197 | RTN3 | T588 | ochoa | Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000269|PubMed:15286784, ECO:0000269|PubMed:16054885, ECO:0000269|PubMed:17031492, ECO:0000269|PubMed:17191123, ECO:0000269|PubMed:25612671}.; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. {ECO:0000269|PubMed:17182608}. |
O95425 | SVIL | T79 | ochoa | Supervillin (Archvillin) (p205/p250) | [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). {ECO:0000269|PubMed:12711699, ECO:0000269|PubMed:19109420}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}. |
O95671 | ASMTL | T234 | ochoa | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase); N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-)] | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}. |
O96017 | CHEK2 | T432 | psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
P00533 | EGFR | T1078 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
P01106 | MYC | T358 | psp | Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) | Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). {ECO:0000250|UniProtKB:P01108, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}. |
P02545 | LMNA | T590 | ochoa | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}. |
P02749 | APOH | T189 | ochoa | Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI) | Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. |
P05455 | SSB | T362 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
P06732 | CKM | T103 | ochoa | Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK) | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. {ECO:0000250|UniProtKB:P00563}. |
P08670 | VIM | T361 | ochoa | Vimentin | Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). {ECO:0000250|UniProtKB:A0A8C0N8E3, ECO:0000250|UniProtKB:P31000}.; FUNCTION: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000269|PubMed:21746880}. |
P09884 | POLA1 | T406 | ochoa | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:31006512, ECO:0000269|PubMed:9518481}. |
P0DJD0 | RGPD1 | T1484 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
P0DJD1 | RGPD2 | T1492 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
P0DPH7 | TUBA3C | T41 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P0DPH8 | TUBA3D | T41 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
P11166 | SLC2A1 | T234 | ochoa | Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter) | Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:10227690, PubMed:10954735, PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:32860739). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P17809, ECO:0000250|UniProtKB:P46896, ECO:0000269|PubMed:10227690, ECO:0000269|PubMed:10954735, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:27078104, ECO:0000269|PubMed:32860739}. |
P11169 | SLC2A3 | T232 | ochoa | Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) | Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:26176916, PubMed:9477959). Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P32037, ECO:0000269|PubMed:26176916, ECO:0000269|PubMed:32860739, ECO:0000269|PubMed:8457197, ECO:0000269|PubMed:9477959}. |
P11908 | PRPS2 | T285 | psp | Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II) | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
P12882 | MYH1 | T1855 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
P12883 | MYH7 | T1653 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P12883 | MYH7 | T1851 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
P13533 | MYH6 | T1655 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
P13535 | MYH8 | T1854 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
P16144 | ITGB4 | T1514 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
P17676 | CEBPB | T266 | psp | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. |
P20290 | BTF3 | T182 | ochoa | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}. |
P20929 | NEB | T35 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
P21333 | FLNA | T2530 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
P23497 | SP100 | T221 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
P26232 | CTNNA2 | T653 | ochoa | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}. |
P29972 | AQP1 | T157 | psp | Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Channel-like integral membrane protein of 28 kDa) (Urine water channel) | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:16682607, ECO:0000269|PubMed:17012249, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:33028705, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:36949749, ECO:0000269|PubMed:8584435, ECO:0000269|PubMed:8703053}. |
P31943 | HNRNPH1 | T100 | ochoa | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}. |
P32519 | ELF1 | T180 | ochoa | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
P35606 | COPB2 | T848 | ochoa | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}. |
P36871 | PGM1 | T513 | ochoa | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802). {ECO:0000269|PubMed:15378030, ECO:0000269|PubMed:17924679, ECO:0000269|PubMed:25288802, ECO:0000305|PubMed:15378030}. |
P38432 | COIL | T485 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
P42694 | HELZ | T1572 | ochoa | Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein) | May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. |
P43243 | MATR3 | T155 | ochoa | Matrin-3 | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:11525732, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:32245947}. |
P46013 | MKI67 | T167 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
P46100 | ATRX | T724 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P46100 | ATRX | T1534 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
P48681 | NES | T322 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
P49757 | NUMB | T102 | psp | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
P49792 | RANBP2 | T2475 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
P49796 | RGS3 | T960 | ochoa | Regulator of G-protein signaling 3 (RGP3) (RGS3) | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:10749886, ECO:0000269|PubMed:11294858, ECO:0000269|PubMed:8602223, ECO:0000269|PubMed:9858594}. |
P52292 | KPNA2 | T73 | ochoa | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}. |
P55795 | HNRNPH2 | T100 | ochoa | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). |
P62258 | YWHAE | T232 | ochoa | 14-3-3 protein epsilon (14-3-3E) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}. |
P68363 | TUBA1B | T41 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
Q01130 | SRSF2 | T22 | ochoa | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
Q02410 | APBA1 | T89 | ochoa | Amyloid-beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:B2RUJ5}. |
Q03431 | PTH1R | T392 | psp | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). {ECO:0000269|PubMed:10913300, ECO:0000269|PubMed:18375760, ECO:0000269|PubMed:19674967, ECO:0000269|PubMed:20172855, ECO:0000269|PubMed:27160269, ECO:0000269|PubMed:30975883, ECO:0000269|PubMed:35932760, ECO:0000269|PubMed:8397094}. |
Q04637 | EIF4G1 | T1073 | ochoa | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29987188}. |
Q05209 | PTPN12 | T598 | ochoa | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
Q09666 | AHNAK | T38 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q09666 | AHNAK | T190 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
Q12968 | NFATC3 | T340 | ochoa | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (PubMed:18815128). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:A0A0G2JTY4, ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:18815128, ECO:0000269|PubMed:32415068}. |
Q13017 | ARHGAP5 | T1217 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
Q13123 | IK | T329 | ochoa | Protein Red (Cytokine IK) (IK factor) (Protein RER) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}. |
Q13315 | ATM | T1884 | ochoa | Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15064416, PubMed:15448695, PubMed:15456891, PubMed:15790808, PubMed:15916964, PubMed:17923702, PubMed:21757780, PubMed:24534091, PubMed:35076389, PubMed:9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15448695, PubMed:15456891, PubMed:15916964, PubMed:17923702, PubMed:24534091, PubMed:9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, FBXO46, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:10550055, PubMed:10766245, PubMed:10802669, PubMed:10839545, PubMed:10910365, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:21757780, PubMed:24534091, PubMed:26240375, PubMed:26774286, PubMed:30171069, PubMed:30612738, PubMed:30886146, PubMed:30952868, PubMed:38128537, PubMed:9733515, PubMed:9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:21757780, ECO:0000269|PubMed:24534091, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30171069, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:30952868, ECO:0000269|PubMed:35076389, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. |
Q13535 | ATR | T1566 | psp | Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:27723717, PubMed:27723720, PubMed:30139873, PubMed:33848395, PubMed:37788673, PubMed:37832547, PubMed:9427750, PubMed:9636169). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:23273981, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809, PubMed:23273981, PubMed:25083873, PubMed:9925639). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Acts as a regulator of the S-G2 transition by restricting the activity of CDK1 during S-phase to prevent premature entry into G2 (PubMed:30139873). Acts as a regulator of the nuclear envelope integrity in response to DNA damage and stress (PubMed:25083873, PubMed:37788673, PubMed:37832547). Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873). Also promotes nuclear envelope rupture in response to DNA damage by mediating phosphorylation of LMNA at 'Ser-282', leading to lamin disassembly (PubMed:37832547). Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at 'Ser-395', priming LMNA for subsequent phosphorylation by CDK1 and micronuclei envelope rupture (PubMed:37788673). The rupture of micronuclear envelope triggers the cGAS-STING pathway thereby activating the type I interferon response and innate immunity (PubMed:37788673). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). {ECO:0000250|UniProtKB:Q9JKK8, ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:25083873, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:33848395, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}. |
Q13561 | DCTN2 | T195 | ochoa | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250|UniProtKB:A0A5G2QD80, ECO:0000250|UniProtKB:Q99KJ8}. |
Q14324 | MYBPC2 | T989 | ochoa | Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform) | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
Q14676 | MDC1 | T448 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
Q15149 | PLEC | T351 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
Q15554 | TERF2 | T230 | psp | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (PubMed:15608617, PubMed:16166375, PubMed:20655466, PubMed:28216226, PubMed:9326950, PubMed:9326951, PubMed:9476899). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (PubMed:16166375, PubMed:20655466). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (PubMed:16166375). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (PubMed:16166375). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (PubMed:20655466). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (PubMed:20655466, PubMed:28216226). Preferentially binds to positive supercoiled DNA (PubMed:15608617, PubMed:20655466). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (PubMed:20655466). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity). {ECO:0000250|UniProtKB:O35144, ECO:0000269|PubMed:15608617, ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:9326950, ECO:0000269|PubMed:9326951, ECO:0000269|PubMed:9476899}. |
Q15762 | CD226 | T310 | ochoa | CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226) | Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:9712030). Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:26755705, PubMed:31253644, PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity). {ECO:0000250|UniProtKB:Q8K4F0, ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:30591568, ECO:0000269|PubMed:31253644, ECO:0000269|PubMed:8673704, ECO:0000269|PubMed:9712030}. |
Q16236 | NFE2L2 | T369 | psp | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) | Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}. |
Q32MZ4 | LRRFIP1 | T533 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
Q58WW2 | DCAF6 | T654 | ochoa | DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}. |
Q5H9L2 | TCEAL5 | T120 | ochoa | Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) | May be involved in transcriptional regulation. |
Q5H9L2 | TCEAL5 | T124 | ochoa | Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5) | May be involved in transcriptional regulation. |
Q5VUJ6 | LRCH2 | T360 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 2 | May play a role in the organization of the cytoskeleton. {ECO:0000250|UniProtKB:Q960C5, ECO:0000250|UniProtKB:Q96II8}. |
Q641Q2 | WASHC2A | T479 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q641Q2 | WASHC2A | T799 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
Q68D20 | PMS2CL | T156 | ochoa | Protein PMS2CL (PMS2-C terminal-like protein) | None |
Q68D85 | NCR3LG1 | T393 | ochoa | Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) | Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}. |
Q6IPX3 | TCEAL6 | T114 | ochoa | Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6) | May be involved in transcriptional regulation. |
Q6IPX3 | TCEAL6 | T118 | ochoa | Transcription elongation factor A protein-like 6 (TCEA-like protein 6) (Transcription elongation factor S-II protein-like 6) | May be involved in transcriptional regulation. |
Q6IQ55 | TTBK2 | T574 | ochoa | Tau-tubulin kinase 2 (EC 2.7.11.1) | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro (PubMed:23141541). Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385). Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity). {ECO:0000250|UniProtKB:Q3UVR3, ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541, ECO:0000269|PubMed:30375385}. |
Q6KC79 | NIPBL | T2667 | ochoa | Nipped-B-like protein (Delangin) (SCC2 homolog) | Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
Q6PEY2 | TUBA3E | T41 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q6PIJ6 | FBXO38 | T591 | ochoa | F-box only protein 38 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q8BMI0, ECO:0000269|PubMed:30487606}. |
Q6UB99 | ANKRD11 | T829 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
Q6UWZ7 | ABRAXAS1 | T46 | ochoa | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538, ECO:0000269|PubMed:26778126}. |
Q709C8 | VPS13C | T869 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
Q71U36 | TUBA1A | T41 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q7Z3D4 | LYSMD3 | T54 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 3 | Essential for Golgi structural integrity. {ECO:0000269|PubMed:29851555}. |
Q7Z3J3 | RGPD4 | T1500 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
Q86UE4 | MTDH | T212 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
Q86V21 | AACS | T83 | ochoa | Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) | Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity). {ECO:0000250|UniProtKB:Q9D2R0, ECO:0000250|UniProtKB:Q9JMI1}. |
Q86V48 | LUZP1 | T953 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
Q8N1F7 | NUP93 | T51 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
Q8N1W1 | ARHGEF28 | T509 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
Q8N5F7 | NKAP | T298 | ochoa | NF-kappa-B-activating protein | Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868). Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814). Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:31587868}. |
Q8NC44 | RETREG2 | T306 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
Q8NC44 | RETREG2 | T329 | ochoa | Reticulophagy regulator 2 | Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250|UniProtKB:Q6NS82, ECO:0000269|PubMed:34338405}. |
Q8TBB5 | KLHDC4 | T403 | ochoa | Kelch domain-containing protein 4 | None |
Q8TDB8 | SLC2A14 | T256 | ochoa | Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14) | Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane. {ECO:0000269|PubMed:28971850}. |
Q8TDD1 | DDX54 | T70 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
Q969E4 | TCEAL3 | T114 | ochoa | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | May be involved in transcriptional regulation. |
Q969E4 | TCEAL3 | T118 | ochoa | Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3) | May be involved in transcriptional regulation. |
Q96B36 | AKT1S1 | T198 | ochoa | Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) | Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity). {ECO:0000250|UniProtKB:Q9D1F4, ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266, ECO:0000269|PubMed:17510057, ECO:0000269|PubMed:18372248, ECO:0000269|PubMed:29236692}. |
Q96B97 | SH3KBP1 | T178 | ochoa | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}. |
Q96EY7 | PTCD3 | T670 | ochoa | Small ribosomal subunit protein mS39 (28S ribosomal protein S39, mitochondrial) (MRP-S39) (Pentatricopeptide repeat domain-containing protein 3, mitochondrial) (Transformation-related gene 15 protein) (TRG-15) | Mitochondrial RNA-binding protein that has a role in mitochondrial translation. {ECO:0000269|PubMed:19427859}. |
Q99497 | PARK7 | T125 | psp | Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) | Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780, PubMed:25416785, PubMed:26995087, PubMed:28993701). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:14749723, PubMed:15502874, PubMed:17015834, PubMed:18711745, PubMed:21097510). Has been described as a protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals (PubMed:25416785, PubMed:28596309). But this function is rebuted by other works (PubMed:27903648, PubMed:31653696). As a protein deglycase, repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (PubMed:25416785, PubMed:26995087, PubMed:28013050). Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair (PubMed:28596309). Protects histones from adduction by methylglyoxal, controls the levels of methylglyoxal-derived argininine modifications on chromatin (PubMed:30150385). Able to remove the glycations and restore histone 3, histone glycation disrupts both local and global chromatin architecture by altering histone-DNA interactions as well as histone acetylation and ubiquitination levels (PubMed:30150385, PubMed:30894531). Displays a very low glyoxalase activity that may reflect its deglycase activity (PubMed:22523093, PubMed:28993701, PubMed:31653696). Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:16632486, PubMed:19229105). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). {ECO:0000250|UniProtKB:Q99LX0, ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12612053, ECO:0000269|PubMed:12855764, ECO:0000269|PubMed:12939276, ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:15502874, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:17015834, ECO:0000269|PubMed:18626009, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:20186336, ECO:0000269|PubMed:20304780, ECO:0000269|PubMed:21097510, ECO:0000269|PubMed:22523093, ECO:0000269|PubMed:23792957, ECO:0000269|PubMed:23847046, ECO:0000269|PubMed:25416785, ECO:0000269|PubMed:26995087, ECO:0000269|PubMed:28013050, ECO:0000269|PubMed:28596309, ECO:0000269|PubMed:28993701, ECO:0000269|PubMed:30150385, ECO:0000269|PubMed:30894531, ECO:0000269|PubMed:9070310}. |
Q9BQE3 | TUBA1C | T41 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
Q9BRL6 | SRSF8 | T22 | ochoa | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}. |
Q9BTC0 | DIDO1 | T328 | ochoa | Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1) | Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}. |
Q9BUZ4 | TRAF4 | T422 | ochoa | TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) | Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273). {ECO:0000250, ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600, ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:30352854, ECO:0000269|PubMed:31076633, ECO:0000269|PubMed:32268273, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33991522}. |
Q9BY89 | KIAA1671 | T1380 | ochoa | Uncharacterized protein KIAA1671 | None |
Q9BYW2 | SETD2 | T1951 | ochoa | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
Q9C0C2 | TNKS1BP1 | T1154 | ochoa | 182 kDa tankyrase-1-binding protein | None |
Q9H1D0 | TRPV6 | T728 | psp | Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) | Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107}. |
Q9H2Y7 | ZNF106 | T1467 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
Q9H334 | FOXP1 | T654 | ochoa | Forkhead box protein P1 (Mac-1-regulated forkhead) (MFH) | Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18347093, PubMed:18799727). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:15286807, ECO:0000269|PubMed:18640093, ECO:0000269|PubMed:18799727, ECO:0000269|PubMed:24023716, ECO:0000269|PubMed:25267198, ECO:0000269|PubMed:26647308, ECO:0000269|PubMed:28218735, ECO:0000305|PubMed:18347093, ECO:0000305|PubMed:24023716}.; FUNCTION: [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). {ECO:0000250|UniProtKB:P58462, ECO:0000269|PubMed:21924763}. |
Q9H3M7 | TXNIP | T348 | ochoa | Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850). {ECO:0000250|UniProtKB:Q8BG60, ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}. |
Q9H501 | ESF1 | T311 | ochoa | ESF1 homolog (ABT1-associated protein) | May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}. |
Q9H9C1 | VIPAS39 | T21 | ochoa | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}. |
Q9HAJ7 | SAP30L | T92 | ochoa | Histone deacetylase complex subunit SAP30L (HCV non-structural protein 4A-transactivated protein 2) (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) | [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). {ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240, ECO:0000269|PubMed:26609676}.; FUNCTION: [Isoform 2]: Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:18070604}.; FUNCTION: [Isoform 3]: Functions as a transcription repressor; its activity is marginally lower than that of isoform 1. {ECO:0000269|PubMed:18070604}. |
Q9HBG7 | LY9 | T532 | ochoa | T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229) | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity). {ECO:0000250|UniProtKB:Q01965, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}. |
Q9NQS5 | GPR84 | T264 | psp | G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33) | G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists (PubMed:16966319). In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (By similarity). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (By similarity). Also plays an important role in inflammation by modulating neutrophil functions (By similarity). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (By similarity). To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils (PubMed:33789297). {ECO:0000250|UniProtKB:Q8CIM5, ECO:0000269|PubMed:16966319, ECO:0000269|PubMed:33789297}. |
Q9NRM7 | LATS2 | T1041 | psp | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976, ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:21952048, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:26598551, ECO:0000269|PubMed:34404733, ECO:0000269|PubMed:39173637}. |
Q9P107 | GMIP | T418 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
Q9P265 | DIP2B | T200 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
Q9UJU6 | DBNL | T21 | ochoa | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
Q9UK61 | TASOR | T1190 | ochoa | Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression (PubMed:26022416, PubMed:28581500). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). {ECO:0000250|UniProtKB:Q69ZR9, ECO:0000269|PubMed:26022416, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:30487602}. |
Q9UKN5 | PRDM4 | T201 | ochoa | PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) | May function as a transcription factor involved in cell differentiation. |
Q9UKX2 | MYH2 | T1857 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
Q9ULH1 | ASAP1 | T906 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
Q9UNF0 | PACSIN2 | T321 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
Q9UQC2 | GAB2 | T636 | ochoa | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}. |
Q9UQF2 | MAPK8IP1 | T103 | psp | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}. |
Q9Y2D8 | SSX2IP | T307 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
Q9Y2J2 | EPB41L3 | T703 | ochoa | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}. |
Q9Y2K5 | R3HDM2 | T147 | ochoa | R3H domain-containing protein 2 | None |
Q9Y3P8 | SIT1 | T98 | ochoa | Signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein) (Suppression-inducing transmembrane adapter 1) (gp30/40) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. {ECO:0000269|PubMed:10209036}. |
Q9Y3P9 | RABGAP1 | T38 | ochoa | Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) | May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition. {ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:16395330}. |
Q9Y462 | ZNF711 | T188 | ochoa | Zinc finger protein 711 (Zinc finger protein 6) | Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806). {ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:31691806}. |
Q9Y4H2 | IRS2 | T815 | ochoa | Insulin receptor substrate 2 (IRS-2) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:15316008, ECO:0000269|PubMed:19109239, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25879670, ECO:0000269|PubMed:32554797}. |
Q9Y623 | MYH4 | T1855 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
Q96QD9 | FYTTD1 | T205 | EPSD|PSP | UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3) | Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}. |
P17980 | PSMC3 | T163 | Sugiyama | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
Q14204 | DYNC1H1 | T4218 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
P07900 | HSP90AA1 | T65 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
P08238 | HSP90AB1 | T60 | Sugiyama | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
Q58FF6 | HSP90AB4P | T36 | Sugiyama | Putative heat shock protein HSP 90-beta 4 | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
Q58FF7 | HSP90AB3P | T60 | Sugiyama | Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
Q58FF8 | HSP90AB2P | T60 | Sugiyama | Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb) | Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}. |
O75390 | CS | T82 | Sugiyama | Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) | Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}. |
Q9H2H8 | PPIL3 | T140 | Sugiyama | Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. |
O94919 | ENDOD1 | T132 | Sugiyama | Endonuclease domain-containing 1 protein (EC 3.1.30.-) | May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. {ECO:0000269|PubMed:32614325}. |
P52948 | NUP98 | T743 | Sugiyama | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}. |
P08253 | MMP2 | T377 | EPSD|PSP | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. |
P08253 | MMP2 | T378 | EPSD|PSP | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION: PEX, the C-terminal non-catalytic fragment of MMP2, possesses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.; FUNCTION: [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. |
O75821 | EIF3G | T244 | Sugiyama | Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44) | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}. |
P24752 | ACAT1 | T241 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
P30044 | PRDX5 | T161 | Sugiyama | Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}. |
Q15118 | PDK1 | T413 | Sugiyama | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}. |
Q15120 | PDK3 | T382 | Sugiyama | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) | Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. {ECO:0000269|PubMed:10748134, ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:16436377, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18718909, ECO:0000269|PubMed:22865452}. |
P61758 | VBP1 | T48 | Sugiyama | Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
Q7RTN6 | STRADA | T38 | Sugiyama | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}. |
Q99832 | CCT7 | T385 | Sugiyama | T-complex protein 1 subunit eta (TCP-1-eta) (EC 3.6.1.-) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
P80303 | NUCB2 | T248 | Sugiyama | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] | Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}. |
P07814 | EPRS1 | T1460 | Sugiyama | Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] | Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro) (PubMed:23263184, PubMed:24100331, PubMed:29576217, PubMed:3290852, PubMed:37212275). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. The GAIT complex inhibits the translation of these mRNAs, allowing interferon-gamma to redirect the function of EPRS1 from protein synthesis to translation inhibition in specific cell contexts (PubMed:15479637, PubMed:23071094). Furthermore, it can function as a downstream effector in the mTORC1 signaling pathway, by promoting the translocation of SLC27A1 from the cytoplasm to the plasma membrane where it mediates the uptake of long-chain fatty acid by adipocytes. Thereby, EPRS1 also plays a role in fat metabolism and more indirectly influences lifespan (PubMed:28178239). {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:29576217, ECO:0000269|PubMed:3290852, ECO:0000269|PubMed:37212275}. |
O75436 | VPS26A | T102 | Sugiyama | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}. |
P43121 | MCAM | T104 | Sugiyama | Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146) | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}. |
O00566 | MPHOSPH10 | T332 | EPSD|PSP | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12655004, ECO:0000269|PubMed:34516797}. |
P11279 | LAMP1 | T138 | Sugiyama | Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a) | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed:37390818). Also plays an important role in NK-cells cytotoxicity (PubMed:2022921, PubMed:23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (PubMed:7685349). {ECO:0000269|PubMed:2022921, ECO:0000269|PubMed:23632890, ECO:0000269|PubMed:23847195, ECO:0000269|PubMed:37390818, ECO:0000269|PubMed:7685349}.; FUNCTION: (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085, PubMed:25972533, PubMed:27605678, PubMed:28448640). Also promotes fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909). {ECO:0000269|PubMed:24970085, ECO:0000269|PubMed:25972533, ECO:0000269|PubMed:27605678, ECO:0000269|PubMed:28448640, ECO:0000269|PubMed:29295909}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}. |
P61221 | ABCE1 | T183 | Sugiyama | ATP-binding cassette sub-family E member 1 (EC 3.6.5.-) (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) | Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (PubMed:20122402, PubMed:21448132). Able to hydrolyze ATP, GTP, UTP and CTP (PubMed:20122402). Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (PubMed:20122402, PubMed:21448132). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (PubMed:20122402, PubMed:21448132). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132). Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy (PubMed:29861391). RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL (PubMed:9660177). Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway (PubMed:11585831, PubMed:9660177, PubMed:9847332). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:20122402, ECO:0000269|PubMed:21448132, ECO:0000269|PubMed:29861391, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:9847332}.; FUNCTION: (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections. {ECO:0000269|PubMed:9660177}. |
P39023 | RPL3 | T189 | Sugiyama | Large ribosomal subunit protein uL3 (60S ribosomal protein L3) (HIV-1 TAR RNA-binding protein B) (TARBP-B) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547, PubMed:35674491). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
Q16643 | DBN1 | T161 | Sugiyama | Drebrin (Developmentally-regulated brain protein) | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}. |
Download
reactome_id | name | p | -log10_p |
---|---|---|---|
R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.140528e-10 | 9.289 |
R-HSA-9646399 | Aggrephagy | 1.818824e-09 | 8.740 |
R-HSA-1640170 | Cell Cycle | 2.980129e-09 | 8.526 |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 4.677349e-09 | 8.330 |
R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 6.929011e-08 | 7.159 |
R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.567684e-07 | 6.805 |
R-HSA-9663891 | Selective autophagy | 1.628430e-07 | 6.788 |
R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.794986e-07 | 6.554 |
R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.878367e-07 | 6.231 |
R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 8.265948e-07 | 6.083 |
R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.963323e-07 | 6.099 |
R-HSA-190872 | Transport of connexons to the plasma membrane | 1.066857e-06 | 5.972 |
R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 1.396879e-06 | 5.855 |
R-HSA-2262752 | Cellular responses to stress | 1.210160e-06 | 5.917 |
R-HSA-9612973 | Autophagy | 1.329239e-06 | 5.876 |
R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.719282e-06 | 5.765 |
R-HSA-1169408 | ISG15 antiviral mechanism | 3.158360e-06 | 5.501 |
R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.596114e-06 | 5.444 |
R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.999848e-06 | 5.398 |
R-HSA-3371556 | Cellular response to heat stress | 3.905851e-06 | 5.408 |
R-HSA-68886 | M Phase | 4.694343e-06 | 5.328 |
R-HSA-913531 | Interferon Signaling | 4.861061e-06 | 5.313 |
R-HSA-8953897 | Cellular responses to stimuli | 5.975142e-06 | 5.224 |
R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 6.936620e-06 | 5.159 |
R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 9.805908e-06 | 5.009 |
R-HSA-69278 | Cell Cycle, Mitotic | 9.447778e-06 | 5.025 |
R-HSA-9609690 | HCMV Early Events | 1.265263e-05 | 4.898 |
R-HSA-437239 | Recycling pathway of L1 | 1.451504e-05 | 4.838 |
R-HSA-1632852 | Macroautophagy | 1.670589e-05 | 4.777 |
R-HSA-9613829 | Chaperone Mediated Autophagy | 2.059679e-05 | 4.686 |
R-HSA-6807878 | COPI-mediated anterograde transport | 2.332863e-05 | 4.632 |
R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 2.108565e-05 | 4.676 |
R-HSA-69473 | G2/M DNA damage checkpoint | 2.365851e-05 | 4.626 |
R-HSA-190861 | Gap junction assembly | 2.781659e-05 | 4.556 |
R-HSA-68882 | Mitotic Anaphase | 3.294720e-05 | 4.482 |
R-HSA-2555396 | Mitotic Metaphase and Anaphase | 3.438984e-05 | 4.464 |
R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 3.548985e-05 | 4.450 |
R-HSA-69275 | G2/M Transition | 3.726776e-05 | 4.429 |
R-HSA-2980766 | Nuclear Envelope Breakdown | 4.158254e-05 | 4.381 |
R-HSA-453274 | Mitotic G2-G2/M phases | 4.087332e-05 | 4.389 |
R-HSA-5617833 | Cilium Assembly | 4.477763e-05 | 4.349 |
R-HSA-68877 | Mitotic Prometaphase | 5.123924e-05 | 4.290 |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 5.238055e-05 | 4.281 |
R-HSA-422475 | Axon guidance | 5.120865e-05 | 4.291 |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 5.971893e-05 | 4.224 |
R-HSA-1280215 | Cytokine Signaling in Immune system | 6.003551e-05 | 4.222 |
R-HSA-390466 | Chaperonin-mediated protein folding | 7.077049e-05 | 4.150 |
R-HSA-438064 | Post NMDA receptor activation events | 7.077049e-05 | 4.150 |
R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 9.258390e-05 | 4.033 |
R-HSA-190828 | Gap junction trafficking | 1.020248e-04 | 3.991 |
R-HSA-391251 | Protein folding | 1.070913e-04 | 3.970 |
R-HSA-9609646 | HCMV Infection | 1.255845e-04 | 3.901 |
R-HSA-9675108 | Nervous system development | 1.232692e-04 | 3.909 |
R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.380092e-04 | 3.860 |
R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 1.383504e-04 | 3.859 |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.354434e-04 | 3.868 |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.671943e-04 | 3.777 |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.610153e-04 | 3.793 |
R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.610153e-04 | 3.793 |
R-HSA-157858 | Gap junction trafficking and regulation | 1.671158e-04 | 3.777 |
R-HSA-3700989 | Transcriptional Regulation by TP53 | 1.820410e-04 | 3.740 |
R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.896038e-04 | 3.722 |
R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.896038e-04 | 3.722 |
R-HSA-69481 | G2/M Checkpoints | 1.964463e-04 | 3.707 |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.134549e-04 | 3.671 |
R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.412263e-04 | 3.618 |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.412263e-04 | 3.618 |
R-HSA-390522 | Striated Muscle Contraction | 2.707294e-04 | 3.567 |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.707294e-04 | 3.567 |
R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.655085e-04 | 3.576 |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.707294e-04 | 3.567 |
R-HSA-2467813 | Separation of Sister Chromatids | 2.728153e-04 | 3.564 |
R-HSA-9818749 | Regulation of NFE2L2 gene expression | 2.942021e-04 | 3.531 |
R-HSA-180746 | Nuclear import of Rev protein | 3.028936e-04 | 3.519 |
R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.031649e-04 | 3.518 |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 3.378735e-04 | 3.471 |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.169168e-04 | 3.380 |
R-HSA-983189 | Kinesins | 4.247206e-04 | 3.372 |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 5.091661e-04 | 3.293 |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.613069e-04 | 3.336 |
R-HSA-373760 | L1CAM interactions | 5.363194e-04 | 3.271 |
R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 5.606657e-04 | 3.251 |
R-HSA-177243 | Interactions of Rev with host cellular proteins | 5.606657e-04 | 3.251 |
R-HSA-176033 | Interactions of Vpr with host cellular proteins | 5.606657e-04 | 3.251 |
R-HSA-199977 | ER to Golgi Anterograde Transport | 5.775211e-04 | 3.238 |
R-HSA-69620 | Cell Cycle Checkpoints | 5.978696e-04 | 3.223 |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 6.159804e-04 | 3.210 |
R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 6.763043e-04 | 3.170 |
R-HSA-2132295 | MHC class II antigen presentation | 7.515544e-04 | 3.124 |
R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 8.354886e-04 | 3.078 |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 9.560774e-04 | 3.020 |
R-HSA-5610787 | Hedgehog 'off' state | 1.031295e-03 | 2.987 |
R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.038097e-03 | 2.984 |
R-HSA-5620924 | Intraflagellar transport | 1.217655e-03 | 2.914 |
R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.558878e-03 | 2.807 |
R-HSA-9833482 | PKR-mediated signaling | 1.587891e-03 | 2.799 |
R-HSA-5358351 | Signaling by Hedgehog | 1.634067e-03 | 2.787 |
R-HSA-5693607 | Processing of DNA double-strand break ends | 1.680045e-03 | 2.775 |
R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.827277e-03 | 2.738 |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.986929e-03 | 2.702 |
R-HSA-168255 | Influenza Infection | 2.017565e-03 | 2.695 |
R-HSA-111465 | Apoptotic cleavage of cellular proteins | 2.097276e-03 | 2.678 |
R-HSA-191859 | snRNP Assembly | 2.641223e-03 | 2.578 |
R-HSA-194441 | Metabolism of non-coding RNA | 2.641223e-03 | 2.578 |
R-HSA-9705683 | SARS-CoV-2-host interactions | 2.744702e-03 | 2.562 |
R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.840697e-03 | 2.547 |
R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 3.376314e-03 | 2.472 |
R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 3.376314e-03 | 2.472 |
R-HSA-5693532 | DNA Double-Strand Break Repair | 2.974381e-03 | 2.527 |
R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.998173e-03 | 2.523 |
R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 3.189060e-03 | 2.496 |
R-HSA-168325 | Viral Messenger RNA Synthesis | 2.992494e-03 | 2.524 |
R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.180232e-03 | 2.498 |
R-HSA-1852241 | Organelle biogenesis and maintenance | 3.180907e-03 | 2.497 |
R-HSA-9707587 | Regulation of HMOX1 expression and activity | 3.282027e-03 | 2.484 |
R-HSA-68875 | Mitotic Prophase | 2.953915e-03 | 2.530 |
R-HSA-6784531 | tRNA processing in the nucleus | 3.180232e-03 | 2.498 |
R-HSA-8939211 | ESR-mediated signaling | 3.523436e-03 | 2.453 |
R-HSA-2028269 | Signaling by Hippo | 3.764084e-03 | 2.424 |
R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.825920e-03 | 2.417 |
R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 3.903261e-03 | 2.409 |
R-HSA-8854518 | AURKA Activation by TPX2 | 4.016676e-03 | 2.396 |
R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.137589e-03 | 2.383 |
R-HSA-5693606 | DNA Double Strand Break Response | 4.248186e-03 | 2.372 |
R-HSA-8953854 | Metabolism of RNA | 4.384627e-03 | 2.358 |
R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.550310e-03 | 2.256 |
R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.629699e-03 | 2.250 |
R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.841057e-03 | 2.234 |
R-HSA-380287 | Centrosome maturation | 6.454460e-03 | 2.190 |
R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 7.103100e-03 | 2.149 |
R-HSA-9018519 | Estrogen-dependent gene expression | 6.005261e-03 | 2.221 |
R-HSA-75153 | Apoptotic execution phase | 7.205399e-03 | 2.142 |
R-HSA-211000 | Gene Silencing by RNA | 6.831968e-03 | 2.165 |
R-HSA-189200 | Cellular hexose transport | 7.302733e-03 | 2.137 |
R-HSA-9006931 | Signaling by Nuclear Receptors | 7.941294e-03 | 2.100 |
R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.610879e-03 | 2.065 |
R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 8.790540e-03 | 2.056 |
R-HSA-8951430 | RUNX3 regulates WNT signaling | 8.790540e-03 | 2.056 |
R-HSA-5336415 | Uptake and function of diphtheria toxin | 8.790540e-03 | 2.056 |
R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 8.895913e-03 | 2.051 |
R-HSA-1266738 | Developmental Biology | 9.028066e-03 | 2.044 |
R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 9.779289e-03 | 2.010 |
R-HSA-168256 | Immune System | 9.905568e-03 | 2.004 |
R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.003855e-02 | 1.998 |
R-HSA-1500620 | Meiosis | 1.020945e-02 | 1.991 |
R-HSA-5339562 | Uptake and actions of bacterial toxins | 1.030196e-02 | 1.987 |
R-HSA-446107 | Type I hemidesmosome assembly | 1.054038e-02 | 1.977 |
R-HSA-72163 | mRNA Splicing - Major Pathway | 1.057755e-02 | 1.976 |
R-HSA-74160 | Gene expression (Transcription) | 1.076424e-02 | 1.968 |
R-HSA-1221632 | Meiotic synapsis | 1.088965e-02 | 1.963 |
R-HSA-5693538 | Homology Directed Repair | 1.099176e-02 | 1.959 |
R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.110837e-02 | 1.954 |
R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.329163e-02 | 1.876 |
R-HSA-72172 | mRNA Splicing | 1.393330e-02 | 1.856 |
R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.431916e-02 | 1.844 |
R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.431916e-02 | 1.844 |
R-HSA-9834752 | Respiratory syncytial virus genome replication | 1.243062e-02 | 1.906 |
R-HSA-162909 | Host Interactions of HIV factors | 1.341542e-02 | 1.872 |
R-HSA-8851680 | Butyrophilin (BTN) family interactions | 1.243062e-02 | 1.906 |
R-HSA-109581 | Apoptosis | 1.375033e-02 | 1.862 |
R-HSA-5357801 | Programmed Cell Death | 1.427284e-02 | 1.845 |
R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 1.445711e-02 | 1.840 |
R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 1.487034e-02 | 1.828 |
R-HSA-182971 | EGFR downregulation | 1.539054e-02 | 1.813 |
R-HSA-5619102 | SLC transporter disorders | 1.573370e-02 | 1.803 |
R-HSA-9832991 | Formation of the posterior neural plate | 1.661573e-02 | 1.779 |
R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 1.766565e-02 | 1.753 |
R-HSA-9824446 | Viral Infection Pathways | 1.788996e-02 | 1.747 |
R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.797432e-02 | 1.745 |
R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.890249e-02 | 1.723 |
R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.011810e-02 | 1.696 |
R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.011810e-02 | 1.696 |
R-HSA-70171 | Glycolysis | 2.029823e-02 | 1.693 |
R-HSA-9711123 | Cellular response to chemical stress | 2.048075e-02 | 1.689 |
R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 2.131348e-02 | 1.671 |
R-HSA-4641265 | Repression of WNT target genes | 2.131348e-02 | 1.671 |
R-HSA-8983711 | OAS antiviral response | 2.131348e-02 | 1.671 |
R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 2.145355e-02 | 1.669 |
R-HSA-162582 | Signal Transduction | 2.213651e-02 | 1.655 |
R-HSA-3371511 | HSF1 activation | 2.274852e-02 | 1.643 |
R-HSA-6804757 | Regulation of TP53 Degradation | 2.274852e-02 | 1.643 |
R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 2.743915e-02 | 1.562 |
R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 2.743915e-02 | 1.562 |
R-HSA-9673013 | Diseases of Telomere Maintenance | 2.743915e-02 | 1.562 |
R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 2.743915e-02 | 1.562 |
R-HSA-5619043 | Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) | 2.743915e-02 | 1.562 |
R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 2.743915e-02 | 1.562 |
R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 2.743915e-02 | 1.562 |
R-HSA-9708530 | Regulation of BACH1 activity | 3.212411e-02 | 1.493 |
R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.199871e-02 | 1.495 |
R-HSA-174430 | Telomere C-strand synthesis initiation | 2.925380e-02 | 1.534 |
R-HSA-5218920 | VEGFR2 mediated vascular permeability | 3.010287e-02 | 1.521 |
R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.925380e-02 | 1.534 |
R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.010287e-02 | 1.521 |
R-HSA-69541 | Stabilization of p53 | 2.702798e-02 | 1.568 |
R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 2.925380e-02 | 1.534 |
R-HSA-165159 | MTOR signalling | 3.335426e-02 | 1.477 |
R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 2.925380e-02 | 1.534 |
R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 2.634576e-02 | 1.579 |
R-HSA-9823739 | Formation of the anterior neural plate | 2.925380e-02 | 1.534 |
R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.702798e-02 | 1.568 |
R-HSA-9679191 | Potential therapeutics for SARS | 3.122489e-02 | 1.505 |
R-HSA-1483249 | Inositol phosphate metabolism | 3.064733e-02 | 1.514 |
R-HSA-1643685 | Disease | 3.234295e-02 | 1.490 |
R-HSA-9679506 | SARS-CoV Infections | 3.188111e-02 | 1.496 |
R-HSA-5619115 | Disorders of transmembrane transporters | 3.461246e-02 | 1.461 |
R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 3.510026e-02 | 1.455 |
R-HSA-9694516 | SARS-CoV-2 Infection | 3.512229e-02 | 1.454 |
R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 3.678082e-02 | 1.434 |
R-HSA-70326 | Glucose metabolism | 3.737882e-02 | 1.427 |
R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 3.817880e-02 | 1.418 |
R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 3.817880e-02 | 1.418 |
R-HSA-5210891 | Uptake and function of anthrax toxins | 3.817880e-02 | 1.418 |
R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 3.840874e-02 | 1.416 |
R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.855928e-02 | 1.414 |
R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.855928e-02 | 1.414 |
R-HSA-5633007 | Regulation of TP53 Activity | 3.952811e-02 | 1.403 |
R-HSA-9675135 | Diseases of DNA repair | 4.038088e-02 | 1.394 |
R-HSA-9915355 | Beta-ketothiolase deficiency | 4.087632e-02 | 1.389 |
R-HSA-5660686 | Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG... | 4.087632e-02 | 1.389 |
R-HSA-5609974 | Defective PGM1 causes PGM1-CDG | 4.087632e-02 | 1.389 |
R-HSA-5619101 | Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG... | 4.087632e-02 | 1.389 |
R-HSA-352238 | Breakdown of the nuclear lamina | 4.087632e-02 | 1.389 |
R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 4.135637e-02 | 1.383 |
R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 4.135637e-02 | 1.383 |
R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 4.135637e-02 | 1.383 |
R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 4.135637e-02 | 1.383 |
R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.160203e-02 | 1.381 |
R-HSA-6794362 | Protein-protein interactions at synapses | 4.197747e-02 | 1.377 |
R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.197747e-02 | 1.377 |
R-HSA-112316 | Neuronal System | 4.233743e-02 | 1.373 |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 4.415244e-02 | 1.355 |
R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 4.462966e-02 | 1.350 |
R-HSA-844456 | The NLRP3 inflammasome | 4.462966e-02 | 1.350 |
R-HSA-9734767 | Developmental Cell Lineages | 4.591603e-02 | 1.338 |
R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 4.610183e-02 | 1.336 |
R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 4.610183e-02 | 1.336 |
R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 5.412865e-02 | 1.267 |
R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 5.412865e-02 | 1.267 |
R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 5.412865e-02 | 1.267 |
R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 5.412865e-02 | 1.267 |
R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 5.412865e-02 | 1.267 |
R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 5.412865e-02 | 1.267 |
R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 5.412865e-02 | 1.267 |
R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 5.412865e-02 | 1.267 |
R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 5.412865e-02 | 1.267 |
R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 5.412865e-02 | 1.267 |
R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 5.412865e-02 | 1.267 |
R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 6.719869e-02 | 1.173 |
R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 4.799546e-02 | 1.319 |
R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.799546e-02 | 1.319 |
R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 4.799546e-02 | 1.319 |
R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 4.799546e-02 | 1.319 |
R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 5.145060e-02 | 1.289 |
R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 5.145060e-02 | 1.289 |
R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 6.610394e-02 | 1.180 |
R-HSA-429947 | Deadenylation of mRNA | 6.610394e-02 | 1.180 |
R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 6.996086e-02 | 1.155 |
R-HSA-177929 | Signaling by EGFR | 6.090416e-02 | 1.215 |
R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 6.996086e-02 | 1.155 |
R-HSA-112399 | IRS-mediated signalling | 6.317957e-02 | 1.199 |
R-HSA-1227986 | Signaling by ERBB2 | 7.023799e-02 | 1.153 |
R-HSA-109704 | PI3K Cascade | 4.809322e-02 | 1.318 |
R-HSA-8876384 | Listeria monocytogenes entry into host cells | 5.499201e-02 | 1.260 |
R-HSA-166208 | mTORC1-mediated signalling | 5.861666e-02 | 1.232 |
R-HSA-3371571 | HSF1-dependent transactivation | 5.012628e-02 | 1.300 |
R-HSA-2682334 | EPH-Ephrin signaling | 5.529663e-02 | 1.257 |
R-HSA-74182 | Ketone body metabolism | 6.232160e-02 | 1.205 |
R-HSA-6794361 | Neurexins and neuroligins | 5.220067e-02 | 1.282 |
R-HSA-77111 | Synthesis of Ketone Bodies | 4.799546e-02 | 1.319 |
R-HSA-199991 | Membrane Trafficking | 4.849020e-02 | 1.314 |
R-HSA-1474165 | Reproduction | 5.465220e-02 | 1.262 |
R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 6.232160e-02 | 1.205 |
R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 5.499201e-02 | 1.260 |
R-HSA-196836 | Vitamin C (ascorbate) metabolism | 5.145060e-02 | 1.289 |
R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 6.610394e-02 | 1.180 |
R-HSA-8863678 | Neurodegenerative Diseases | 6.610394e-02 | 1.180 |
R-HSA-112315 | Transmission across Chemical Synapses | 5.222676e-02 | 1.282 |
R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.550248e-02 | 1.256 |
R-HSA-72306 | tRNA processing | 5.014811e-02 | 1.300 |
R-HSA-212436 | Generic Transcription Pathway | 7.231669e-02 | 1.141 |
R-HSA-9009391 | Extra-nuclear estrogen signaling | 7.245900e-02 | 1.140 |
R-HSA-2428928 | IRS-related events triggered by IGF1R | 7.266672e-02 | 1.139 |
R-HSA-1643713 | Signaling by EGFR in Cancer | 7.388960e-02 | 1.131 |
R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 7.388960e-02 | 1.131 |
R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 7.388960e-02 | 1.131 |
R-HSA-162599 | Late Phase of HIV Life Cycle | 7.432245e-02 | 1.129 |
R-HSA-5663205 | Infectious disease | 7.740653e-02 | 1.111 |
R-HSA-373755 | Semaphorin interactions | 7.763534e-02 | 1.110 |
R-HSA-3928663 | EPHA-mediated growth cone collapse | 7.788745e-02 | 1.109 |
R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 7.788745e-02 | 1.109 |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 7.807977e-02 | 1.107 |
R-HSA-73857 | RNA Polymerase II Transcription | 7.878017e-02 | 1.104 |
R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 8.008892e-02 | 1.096 |
R-HSA-9818035 | NFE2L2 regulating ER-stress associated genes | 8.008892e-02 | 1.096 |
R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 8.008892e-02 | 1.096 |
R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 8.008892e-02 | 1.096 |
R-HSA-205025 | NADE modulates death signalling | 8.008892e-02 | 1.096 |
R-HSA-74751 | Insulin receptor signalling cascade | 8.017428e-02 | 1.096 |
R-HSA-2428924 | IGF1R signaling cascade | 8.017428e-02 | 1.096 |
R-HSA-622312 | Inflammasomes | 8.195179e-02 | 1.086 |
R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 8.274899e-02 | 1.082 |
R-HSA-73894 | DNA Repair | 8.588681e-02 | 1.066 |
R-HSA-9615710 | Late endosomal microautophagy | 8.608002e-02 | 1.065 |
R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 8.608002e-02 | 1.065 |
R-HSA-9759475 | Regulation of CDH11 Expression and Function | 8.608002e-02 | 1.065 |
R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex | 8.608002e-02 | 1.065 |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 8.791631e-02 | 1.056 |
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 8.791631e-02 | 1.056 |
R-HSA-1250196 | SHC1 events in ERBB2 signaling | 9.026963e-02 | 1.044 |
R-HSA-9008059 | Interleukin-37 signaling | 9.026963e-02 | 1.044 |
R-HSA-9818025 | NFE2L2 regulating TCA cycle genes | 9.280180e-02 | 1.032 |
R-HSA-9818026 | NFE2L2 regulating inflammation associated genes | 9.280180e-02 | 1.032 |
R-HSA-74713 | IRS activation | 9.280180e-02 | 1.032 |
R-HSA-165158 | Activation of AKT2 | 9.280180e-02 | 1.032 |
R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 9.280180e-02 | 1.032 |
R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 9.280180e-02 | 1.032 |
R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 9.280180e-02 | 1.032 |
R-HSA-8866376 | Reelin signalling pathway | 9.280180e-02 | 1.032 |
R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 1.053398e-01 | 0.977 |
R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 1.053398e-01 | 0.977 |
R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 1.053398e-01 | 0.977 |
R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 1.177052e-01 | 0.929 |
R-HSA-9027283 | Erythropoietin activates STAT5 | 1.177052e-01 | 0.929 |
R-HSA-9645135 | STAT5 Activation | 1.177052e-01 | 0.929 |
R-HSA-112412 | SOS-mediated signalling | 1.299005e-01 | 0.886 |
R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.419280e-01 | 0.848 |
R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.537899e-01 | 0.813 |
R-HSA-9634635 | Estrogen-stimulated signaling through PRKCZ | 1.537899e-01 | 0.813 |
R-HSA-201688 | WNT mediated activation of DVL | 1.537899e-01 | 0.813 |
R-HSA-9027277 | Erythropoietin activates Phospholipase C gamma (PLCG) | 1.654886e-01 | 0.781 |
R-HSA-390450 | Folding of actin by CCT/TriC | 1.654886e-01 | 0.781 |
R-HSA-68952 | DNA replication initiation | 1.654886e-01 | 0.781 |
R-HSA-9818028 | NFE2L2 regulates pentose phosphate pathway genes | 1.884051e-01 | 0.725 |
R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 1.257117e-01 | 0.901 |
R-HSA-9670095 | Inhibition of DNA recombination at telomere | 1.397397e-01 | 0.855 |
R-HSA-141424 | Amplification of signal from the kinetochores | 1.441670e-01 | 0.841 |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.441670e-01 | 0.841 |
R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.638840e-01 | 0.785 |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.672460e-01 | 0.777 |
R-HSA-72689 | Formation of a pool of free 40S subunits | 1.843482e-01 | 0.734 |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.075934e-01 | 0.968 |
R-HSA-9948299 | Ribosome-associated quality control | 1.712963e-01 | 0.766 |
R-HSA-6798695 | Neutrophil degranulation | 1.325553e-01 | 0.878 |
R-HSA-9664873 | Pexophagy | 1.654886e-01 | 0.781 |
R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 1.843482e-01 | 0.734 |
R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.492713e-01 | 0.826 |
R-HSA-9762292 | Regulation of CDH11 function | 1.654886e-01 | 0.781 |
R-HSA-198203 | PI3K/AKT activation | 1.654886e-01 | 0.781 |
R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.770263e-01 | 0.752 |
R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.785686e-01 | 0.748 |
R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 1.211153e-01 | 0.917 |
R-HSA-72737 | Cap-dependent Translation Initiation | 1.092727e-01 | 0.961 |
R-HSA-4641258 | Degradation of DVL | 1.257117e-01 | 0.901 |
R-HSA-72613 | Eukaryotic Translation Initiation | 1.092727e-01 | 0.961 |
R-HSA-2025928 | Calcineurin activates NFAT | 1.537899e-01 | 0.813 |
R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.492713e-01 | 0.826 |
R-HSA-5693537 | Resolution of D-Loop Structures | 1.075934e-01 | 0.968 |
R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 1.053398e-01 | 0.977 |
R-HSA-169911 | Regulation of Apoptosis | 1.165620e-01 | 0.933 |
R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.031823e-01 | 0.986 |
R-HSA-4608870 | Asymmetric localization of PCP proteins | 1.686994e-01 | 0.773 |
R-HSA-176187 | Activation of ATR in response to replication stress | 1.031823e-01 | 0.986 |
R-HSA-8856828 | Clathrin-mediated endocytosis | 1.877204e-01 | 0.726 |
R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.299005e-01 | 0.886 |
R-HSA-73843 | 5-Phosphoribose 1-diphosphate biosynthesis | 1.537899e-01 | 0.813 |
R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.654886e-01 | 0.781 |
R-HSA-192905 | vRNP Assembly | 1.770263e-01 | 0.752 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.774510e-01 | 0.751 |
R-HSA-1839124 | FGFR1 mutant receptor activation | 1.031823e-01 | 0.986 |
R-HSA-74749 | Signal attenuation | 1.654886e-01 | 0.781 |
R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 1.120540e-01 | 0.951 |
R-HSA-5655302 | Signaling by FGFR1 in disease | 1.492713e-01 | 0.826 |
R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 1.031823e-01 | 0.986 |
R-HSA-74752 | Signaling by Insulin receptor | 1.706282e-01 | 0.768 |
R-HSA-5653890 | Lactose synthesis | 1.177052e-01 | 0.929 |
R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.654886e-01 | 0.781 |
R-HSA-77108 | Utilization of Ketone Bodies | 1.770263e-01 | 0.752 |
R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.884051e-01 | 0.725 |
R-HSA-3858494 | Beta-catenin independent WNT signaling | 1.659387e-01 | 0.780 |
R-HSA-9766229 | Degradation of CDH1 | 1.885241e-01 | 0.725 |
R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.070399e-01 | 0.970 |
R-HSA-114608 | Platelet degranulation | 1.376328e-01 | 0.861 |
R-HSA-194138 | Signaling by VEGF | 1.327134e-01 | 0.877 |
R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 1.736224e-01 | 0.760 |
R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 1.736224e-01 | 0.760 |
R-HSA-444257 | RSK activation | 1.419280e-01 | 0.848 |
R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.884051e-01 | 0.725 |
R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 1.350259e-01 | 0.870 |
R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 9.614177e-02 | 1.017 |
R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.537899e-01 | 0.813 |
R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 1.554113e-01 | 0.809 |
R-HSA-446728 | Cell junction organization | 1.244171e-01 | 0.905 |
R-HSA-8853659 | RET signaling | 1.211153e-01 | 0.917 |
R-HSA-9764302 | Regulation of CDH19 Expression and Function | 1.053398e-01 | 0.977 |
R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.419280e-01 | 0.848 |
R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 1.397397e-01 | 0.855 |
R-HSA-3371568 | Attenuation phase | 1.397397e-01 | 0.855 |
R-HSA-9837999 | Mitochondrial protein degradation | 1.774510e-01 | 0.751 |
R-HSA-5653656 | Vesicle-mediated transport | 1.178620e-01 | 0.929 |
R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.757029e-01 | 0.755 |
R-HSA-5632684 | Hedgehog 'on' state | 9.892060e-02 | 1.005 |
R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.654886e-01 | 0.781 |
R-HSA-3928662 | EPHB-mediated forward signaling | 1.638011e-01 | 0.786 |
R-HSA-1280218 | Adaptive Immune System | 1.621009e-01 | 0.790 |
R-HSA-1433557 | Signaling by SCF-KIT | 1.589292e-01 | 0.799 |
R-HSA-69206 | G1/S Transition | 1.327134e-01 | 0.877 |
R-HSA-430116 | GP1b-IX-V activation signalling | 1.537899e-01 | 0.813 |
R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 1.885241e-01 | 0.725 |
R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.878233e-01 | 0.726 |
R-HSA-2586552 | Signaling by Leptin | 1.654886e-01 | 0.781 |
R-HSA-9610379 | HCMV Late Events | 9.912294e-02 | 1.004 |
R-HSA-1980143 | Signaling by NOTCH1 | 1.132873e-01 | 0.946 |
R-HSA-9861718 | Regulation of pyruvate metabolism | 1.736224e-01 | 0.760 |
R-HSA-9707564 | Cytoprotection by HMOX1 | 1.346256e-01 | 0.871 |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.257117e-01 | 0.901 |
R-HSA-9645723 | Diseases of programmed cell death | 1.539248e-01 | 0.813 |
R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.654886e-01 | 0.781 |
R-HSA-69205 | G1/S-Specific Transcription | 1.211153e-01 | 0.917 |
R-HSA-446203 | Asparagine N-linked glycosylation | 1.671637e-01 | 0.777 |
R-HSA-162906 | HIV Infection | 1.324702e-01 | 0.878 |
R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 1.835363e-01 | 0.736 |
R-HSA-449147 | Signaling by Interleukins | 1.187351e-01 | 0.925 |
R-HSA-162587 | HIV Life Cycle | 9.912294e-02 | 1.004 |
R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 1.350259e-01 | 0.870 |
R-HSA-1500931 | Cell-Cell communication | 1.899520e-01 | 0.721 |
R-HSA-157579 | Telomere Maintenance | 1.913154e-01 | 0.718 |
R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.913154e-01 | 0.718 |
R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.961173e-01 | 0.707 |
R-HSA-9027276 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | 1.996274e-01 | 0.700 |
R-HSA-69109 | Leading Strand Synthesis | 1.996274e-01 | 0.700 |
R-HSA-69091 | Polymerase switching | 1.996274e-01 | 0.700 |
R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 1.996274e-01 | 0.700 |
R-HSA-3000484 | Scavenging by Class F Receptors | 1.996274e-01 | 0.700 |
R-HSA-179812 | GRB2 events in EGFR signaling | 1.996274e-01 | 0.700 |
R-HSA-1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.996274e-01 | 0.700 |
R-HSA-8983432 | Interleukin-15 signaling | 1.996274e-01 | 0.700 |
R-HSA-9617629 | Regulation of FOXO transcriptional activity by acetylation | 1.996274e-01 | 0.700 |
R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.996274e-01 | 0.700 |
R-HSA-69618 | Mitotic Spindle Checkpoint | 2.018883e-01 | 0.695 |
R-HSA-72187 | mRNA 3'-end processing | 2.035928e-01 | 0.691 |
R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 2.106951e-01 | 0.676 |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.132457e-01 | 0.671 |
R-HSA-72649 | Translation initiation complex formation | 2.137124e-01 | 0.670 |
R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.161918e-01 | 0.665 |
R-HSA-69166 | Removal of the Flap Intermediate | 2.216105e-01 | 0.654 |
R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.216105e-01 | 0.654 |
R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 2.216105e-01 | 0.654 |
R-HSA-5607763 | CLEC7A (Dectin-1) induces NFAT activation | 2.216105e-01 | 0.654 |
R-HSA-397014 | Muscle contraction | 2.232399e-01 | 0.651 |
R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.238784e-01 | 0.650 |
R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 2.238784e-01 | 0.650 |
R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 2.238784e-01 | 0.650 |
R-HSA-9692914 | SARS-CoV-1-host interactions | 2.270561e-01 | 0.644 |
R-HSA-9764561 | Regulation of CDH1 Function | 2.289757e-01 | 0.640 |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.307010e-01 | 0.637 |
R-HSA-9700206 | Signaling by ALK in cancer | 2.307010e-01 | 0.637 |
R-HSA-9711097 | Cellular response to starvation | 2.307735e-01 | 0.637 |
R-HSA-9027284 | Erythropoietin activates RAS | 2.323755e-01 | 0.634 |
R-HSA-180336 | SHC1 events in EGFR signaling | 2.323755e-01 | 0.634 |
R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.323755e-01 | 0.634 |
R-HSA-69183 | Processive synthesis on the lagging strand | 2.323755e-01 | 0.634 |
R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.323755e-01 | 0.634 |
R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.323755e-01 | 0.634 |
R-HSA-446353 | Cell-extracellular matrix interactions | 2.323755e-01 | 0.634 |
R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.340809e-01 | 0.631 |
R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.340809e-01 | 0.631 |
R-HSA-180786 | Extension of Telomeres | 2.391927e-01 | 0.621 |
R-HSA-429914 | Deadenylation-dependent mRNA decay | 2.391927e-01 | 0.621 |
R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 2.391927e-01 | 0.621 |
R-HSA-9006925 | Intracellular signaling by second messengers | 2.414079e-01 | 0.617 |
R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 2.429924e-01 | 0.614 |
R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 2.429924e-01 | 0.614 |
R-HSA-9664420 | Killing mechanisms | 2.429924e-01 | 0.614 |
R-HSA-5635838 | Activation of SMO | 2.429924e-01 | 0.614 |
R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 2.429924e-01 | 0.614 |
R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 2.443101e-01 | 0.612 |
R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 2.443101e-01 | 0.612 |
R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 2.443101e-01 | 0.612 |
R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 2.443101e-01 | 0.612 |
R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 2.443101e-01 | 0.612 |
R-HSA-5362517 | Signaling by Retinoic Acid | 2.443101e-01 | 0.612 |
R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 2.490788e-01 | 0.604 |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 2.490788e-01 | 0.604 |
R-HSA-73856 | RNA Polymerase II Transcription Termination | 2.494319e-01 | 0.603 |
R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.534630e-01 | 0.596 |
R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 2.534630e-01 | 0.596 |
R-HSA-432047 | Passive transport by Aquaporins | 2.534630e-01 | 0.596 |
R-HSA-70370 | Galactose catabolism | 2.534630e-01 | 0.596 |
R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 2.545570e-01 | 0.594 |
R-HSA-9707616 | Heme signaling | 2.545570e-01 | 0.594 |
R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 2.637895e-01 | 0.579 |
R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.637895e-01 | 0.579 |
R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 2.648129e-01 | 0.577 |
R-HSA-180292 | GAB1 signalosome | 2.739737e-01 | 0.562 |
R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.739737e-01 | 0.562 |
R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 2.739737e-01 | 0.562 |
R-HSA-8849932 | Synaptic adhesion-like molecules | 2.739737e-01 | 0.562 |
R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 2.750697e-01 | 0.561 |
R-HSA-1257604 | PIP3 activates AKT signaling | 2.759813e-01 | 0.559 |
R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.790444e-01 | 0.554 |
R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.790444e-01 | 0.554 |
R-HSA-195721 | Signaling by WNT | 2.830797e-01 | 0.548 |
R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.840177e-01 | 0.547 |
R-HSA-113510 | E2F mediated regulation of DNA replication | 2.840177e-01 | 0.547 |
R-HSA-1480926 | O2/CO2 exchange in erythrocytes | 2.840177e-01 | 0.547 |
R-HSA-1237044 | Erythrocytes take up carbon dioxide and release oxygen | 2.840177e-01 | 0.547 |
R-HSA-73886 | Chromosome Maintenance | 2.901794e-01 | 0.537 |
R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.904398e-01 | 0.537 |
R-HSA-72766 | Translation | 2.909621e-01 | 0.536 |
R-HSA-5620916 | VxPx cargo-targeting to cilium | 2.939234e-01 | 0.532 |
R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 2.939234e-01 | 0.532 |
R-HSA-6807004 | Negative regulation of MET activity | 2.939234e-01 | 0.532 |
R-HSA-71288 | Creatine metabolism | 2.939234e-01 | 0.532 |
R-HSA-445144 | Signal transduction by L1 | 2.939234e-01 | 0.532 |
R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 2.939234e-01 | 0.532 |
R-HSA-3322077 | Glycogen synthesis | 2.939234e-01 | 0.532 |
R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 2.955555e-01 | 0.529 |
R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.955555e-01 | 0.529 |
R-HSA-157118 | Signaling by NOTCH | 2.961565e-01 | 0.528 |
R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.977166e-01 | 0.526 |
R-HSA-9816359 | Maternal to zygotic transition (MZT) | 2.977166e-01 | 0.526 |
R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.006658e-01 | 0.522 |
R-HSA-2559583 | Cellular Senescence | 3.006676e-01 | 0.522 |
R-HSA-69186 | Lagging Strand Synthesis | 3.036926e-01 | 0.518 |
R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.057701e-01 | 0.515 |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.057701e-01 | 0.515 |
R-HSA-201681 | TCF dependent signaling in response to WNT | 3.099973e-01 | 0.509 |
R-HSA-4086398 | Ca2+ pathway | 3.108675e-01 | 0.507 |
R-HSA-1226099 | Signaling by FGFR in disease | 3.159572e-01 | 0.500 |
R-HSA-71403 | Citric acid cycle (TCA cycle) | 3.210384e-01 | 0.493 |
R-HSA-6803529 | FGFR2 alternative splicing | 3.228291e-01 | 0.491 |
R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.228291e-01 | 0.491 |
R-HSA-3238698 | WNT ligand biogenesis and trafficking | 3.228291e-01 | 0.491 |
R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.228291e-01 | 0.491 |
R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.228291e-01 | 0.491 |
R-HSA-8964038 | LDL clearance | 3.228291e-01 | 0.491 |
R-HSA-199418 | Negative regulation of the PI3K/AKT network | 3.279481e-01 | 0.484 |
R-HSA-912526 | Interleukin receptor SHC signaling | 3.322001e-01 | 0.479 |
R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 3.322001e-01 | 0.479 |
R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 3.322001e-01 | 0.479 |
R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.322001e-01 | 0.479 |
R-HSA-3000170 | Syndecan interactions | 3.322001e-01 | 0.479 |
R-HSA-982772 | Growth hormone receptor signaling | 3.322001e-01 | 0.479 |
R-HSA-4086400 | PCP/CE pathway | 3.362242e-01 | 0.473 |
R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 3.414420e-01 | 0.467 |
R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 3.442118e-01 | 0.463 |
R-HSA-400685 | Sema4D in semaphorin signaling | 3.505566e-01 | 0.455 |
R-HSA-1482801 | Acyl chain remodelling of PS | 3.505566e-01 | 0.455 |
R-HSA-5218921 | VEGFR2 mediated cell proliferation | 3.505566e-01 | 0.455 |
R-HSA-3000157 | Laminin interactions | 3.505566e-01 | 0.455 |
R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 3.505566e-01 | 0.455 |
R-HSA-70221 | Glycogen breakdown (glycogenolysis) | 3.505566e-01 | 0.455 |
R-HSA-1266695 | Interleukin-7 signaling | 3.505566e-01 | 0.455 |
R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 3.506777e-01 | 0.455 |
R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 3.563114e-01 | 0.448 |
R-HSA-525793 | Myogenesis | 3.595456e-01 | 0.444 |
R-HSA-9703465 | Signaling by FLT3 fusion proteins | 3.595456e-01 | 0.444 |
R-HSA-5689901 | Metalloprotease DUBs | 3.595456e-01 | 0.444 |
R-HSA-3295583 | TRP channels | 3.595456e-01 | 0.444 |
R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.595456e-01 | 0.444 |
R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 3.595456e-01 | 0.444 |
R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 3.619355e-01 | 0.441 |
R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 3.684107e-01 | 0.434 |
R-HSA-171306 | Packaging Of Telomere Ends | 3.684107e-01 | 0.434 |
R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.684107e-01 | 0.434 |
R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.684107e-01 | 0.434 |
R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 3.684107e-01 | 0.434 |
R-HSA-381119 | Unfolded Protein Response (UPR) | 3.694607e-01 | 0.432 |
R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 3.726362e-01 | 0.429 |
R-HSA-376176 | Signaling by ROBO receptors | 3.726362e-01 | 0.429 |
R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 3.769703e-01 | 0.424 |
R-HSA-171319 | Telomere Extension By Telomerase | 3.771536e-01 | 0.423 |
R-HSA-380994 | ATF4 activates genes in response to endoplasmic reticulum stress | 3.771536e-01 | 0.423 |
R-HSA-381038 | XBP1(S) activates chaperone genes | 3.811073e-01 | 0.419 |
R-HSA-9006335 | Signaling by Erythropoietin | 3.857760e-01 | 0.414 |
R-HSA-1592389 | Activation of Matrix Metalloproteinases | 3.857760e-01 | 0.414 |
R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 3.857760e-01 | 0.414 |
R-HSA-70268 | Pyruvate metabolism | 3.860193e-01 | 0.413 |
R-HSA-76002 | Platelet activation, signaling and aggregation | 3.888329e-01 | 0.410 |
R-HSA-156902 | Peptide chain elongation | 3.909143e-01 | 0.408 |
R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.942796e-01 | 0.404 |
R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 3.942796e-01 | 0.404 |
R-HSA-68962 | Activation of the pre-replicative complex | 3.942796e-01 | 0.404 |
R-HSA-114452 | Activation of BH3-only proteins | 3.942796e-01 | 0.404 |
R-HSA-202424 | Downstream TCR signaling | 4.006516e-01 | 0.397 |
R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.026660e-01 | 0.395 |
R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 4.026660e-01 | 0.395 |
R-HSA-5683057 | MAPK family signaling cascades | 4.026865e-01 | 0.395 |
R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.054931e-01 | 0.392 |
R-HSA-69242 | S Phase | 4.068053e-01 | 0.391 |
R-HSA-381070 | IRE1alpha activates chaperones | 4.103159e-01 | 0.387 |
R-HSA-9758941 | Gastrulation | 4.105072e-01 | 0.387 |
R-HSA-69190 | DNA strand elongation | 4.109368e-01 | 0.386 |
R-HSA-9675126 | Diseases of mitotic cell cycle | 4.109368e-01 | 0.386 |
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.109368e-01 | 0.386 |
R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.109368e-01 | 0.386 |
R-HSA-1538133 | G0 and Early G1 | 4.109368e-01 | 0.386 |
R-HSA-156842 | Eukaryotic Translation Elongation | 4.151195e-01 | 0.382 |
R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.190936e-01 | 0.378 |
R-HSA-5675482 | Regulation of necroptotic cell death | 4.190936e-01 | 0.378 |
R-HSA-397795 | G-protein beta:gamma signalling | 4.190936e-01 | 0.378 |
R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis | 4.190936e-01 | 0.378 |
R-HSA-354192 | Integrin signaling | 4.190936e-01 | 0.378 |
R-HSA-446652 | Interleukin-1 family signaling | 4.215699e-01 | 0.375 |
R-HSA-418990 | Adherens junctions interactions | 4.225302e-01 | 0.374 |
R-HSA-1474290 | Collagen formation | 4.246679e-01 | 0.372 |
R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.271379e-01 | 0.369 |
R-HSA-1482788 | Acyl chain remodelling of PC | 4.271379e-01 | 0.369 |
R-HSA-180534 | Vpu mediated degradation of CD4 | 4.271379e-01 | 0.369 |
R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 4.294118e-01 | 0.367 |
R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.294118e-01 | 0.367 |
R-HSA-72764 | Eukaryotic Translation Termination | 4.341352e-01 | 0.362 |
R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.350713e-01 | 0.361 |
R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 4.350713e-01 | 0.361 |
R-HSA-203615 | eNOS activation | 4.350713e-01 | 0.361 |
R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 4.350713e-01 | 0.361 |
R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.350713e-01 | 0.361 |
R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.350713e-01 | 0.361 |
R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 4.388377e-01 | 0.358 |
R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 4.388377e-01 | 0.358 |
R-HSA-392499 | Metabolism of proteins | 4.397730e-01 | 0.357 |
R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4.428954e-01 | 0.354 |
R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.428954e-01 | 0.354 |
R-HSA-1482839 | Acyl chain remodelling of PE | 4.428954e-01 | 0.354 |
R-HSA-381042 | PERK regulates gene expression | 4.428954e-01 | 0.354 |
R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 4.434799e-01 | 0.353 |
R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.435188e-01 | 0.353 |
R-HSA-9682385 | FLT3 signaling in disease | 4.506115e-01 | 0.346 |
R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.506115e-01 | 0.346 |
R-HSA-114604 | GPVI-mediated activation cascade | 4.506115e-01 | 0.346 |
R-HSA-111933 | Calmodulin induced events | 4.506115e-01 | 0.346 |
R-HSA-111997 | CaM pathway | 4.506115e-01 | 0.346 |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.506115e-01 | 0.346 |
R-HSA-74158 | RNA Polymerase III Transcription | 4.506115e-01 | 0.346 |
R-HSA-193704 | p75 NTR receptor-mediated signalling | 4.528161e-01 | 0.344 |
R-HSA-4641257 | Degradation of AXIN | 4.582213e-01 | 0.339 |
R-HSA-110331 | Cleavage of the damaged purine | 4.582213e-01 | 0.339 |
R-HSA-2408557 | Selenocysteine synthesis | 4.620248e-01 | 0.335 |
R-HSA-2408522 | Selenoamino acid metabolism | 4.650626e-01 | 0.332 |
R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.657261e-01 | 0.332 |
R-HSA-73927 | Depurination | 4.657261e-01 | 0.332 |
R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 4.657261e-01 | 0.332 |
R-HSA-5213460 | RIPK1-mediated regulated necrosis | 4.657261e-01 | 0.332 |
R-HSA-192823 | Viral mRNA Translation | 4.711427e-01 | 0.327 |
R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.731274e-01 | 0.325 |
R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 4.731274e-01 | 0.325 |
R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.731274e-01 | 0.325 |
R-HSA-71336 | Pentose phosphate pathway | 4.731274e-01 | 0.325 |
R-HSA-201556 | Signaling by ALK | 4.731274e-01 | 0.325 |
R-HSA-8964043 | Plasma lipoprotein clearance | 4.731274e-01 | 0.325 |
R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.804266e-01 | 0.318 |
R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.804266e-01 | 0.318 |
R-HSA-451927 | Interleukin-2 family signaling | 4.804266e-01 | 0.318 |
R-HSA-8982491 | Glycogen metabolism | 4.804266e-01 | 0.318 |
R-HSA-9607240 | FLT3 Signaling | 4.876252e-01 | 0.312 |
R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.876252e-01 | 0.312 |
R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.876252e-01 | 0.312 |
R-HSA-8853884 | Transcriptional Regulation by VENTX | 4.876252e-01 | 0.312 |
R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.876252e-01 | 0.312 |
R-HSA-3214841 | PKMTs methylate histone lysines | 4.876252e-01 | 0.312 |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.897707e-01 | 0.310 |
R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.932556e-01 | 0.307 |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 4.935278e-01 | 0.307 |
R-HSA-69239 | Synthesis of DNA | 4.935278e-01 | 0.307 |
R-HSA-9932298 | Degradation of CRY and PER proteins | 4.947244e-01 | 0.306 |
R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.947244e-01 | 0.306 |
R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.947244e-01 | 0.306 |
R-HSA-442660 | SLC-mediated transport of neurotransmitters | 4.947244e-01 | 0.306 |
R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 4.967289e-01 | 0.304 |
R-HSA-379716 | Cytosolic tRNA aminoacylation | 5.017257e-01 | 0.300 |
R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 5.017257e-01 | 0.300 |
R-HSA-111996 | Ca-dependent events | 5.017257e-01 | 0.300 |
R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.017257e-01 | 0.300 |
R-HSA-73928 | Depyrimidination | 5.017257e-01 | 0.300 |
R-HSA-69002 | DNA Replication Pre-Initiation | 5.023136e-01 | 0.299 |
R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.036396e-01 | 0.298 |
R-HSA-202403 | TCR signaling | 5.066698e-01 | 0.295 |
R-HSA-9678108 | SARS-CoV-1 Infection | 5.070769e-01 | 0.295 |
R-HSA-9710421 | Defective pyroptosis | 5.086305e-01 | 0.294 |
R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.086305e-01 | 0.294 |
R-HSA-8854214 | TBC/RABGAPs | 5.086305e-01 | 0.294 |
R-HSA-9824439 | Bacterial Infection Pathways | 5.094497e-01 | 0.293 |
R-HSA-9907900 | Proteasome assembly | 5.154399e-01 | 0.288 |
R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.154399e-01 | 0.288 |
R-HSA-421270 | Cell-cell junction organization | 5.216485e-01 | 0.283 |
R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 5.221555e-01 | 0.282 |
R-HSA-6783310 | Fanconi Anemia Pathway | 5.221555e-01 | 0.282 |
R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 5.221555e-01 | 0.282 |
R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.221555e-01 | 0.282 |
R-HSA-1489509 | DAG and IP3 signaling | 5.221555e-01 | 0.282 |
R-HSA-9824272 | Somitogenesis | 5.221555e-01 | 0.282 |
R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.221555e-01 | 0.282 |
R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.287783e-01 | 0.277 |
R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.287783e-01 | 0.277 |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.287783e-01 | 0.277 |
R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.322821e-01 | 0.274 |
R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 5.353098e-01 | 0.271 |
R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.359914e-01 | 0.271 |
R-HSA-389356 | Co-stimulation by CD28 | 5.417512e-01 | 0.266 |
R-HSA-9007101 | Rab regulation of trafficking | 5.447456e-01 | 0.264 |
R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.505953e-01 | 0.259 |
R-HSA-5658442 | Regulation of RAS by GAPs | 5.543684e-01 | 0.256 |
R-HSA-912446 | Meiotic recombination | 5.605467e-01 | 0.251 |
R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.605467e-01 | 0.251 |
R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 5.605467e-01 | 0.251 |
R-HSA-5358346 | Hedgehog ligand biogenesis | 5.605467e-01 | 0.251 |
R-HSA-70895 | Branched-chain amino acid catabolism | 5.605467e-01 | 0.251 |
R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.666397e-01 | 0.247 |
R-HSA-68949 | Orc1 removal from chromatin | 5.666397e-01 | 0.247 |
R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.666397e-01 | 0.247 |
R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.666397e-01 | 0.247 |
R-HSA-109582 | Hemostasis | 5.671257e-01 | 0.246 |
R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.726487e-01 | 0.242 |
R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.726487e-01 | 0.242 |
R-HSA-8948751 | Regulation of PTEN stability and activity | 5.726487e-01 | 0.242 |
R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.785746e-01 | 0.238 |
R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.785746e-01 | 0.238 |
R-HSA-3214815 | HDACs deacetylate histones | 5.844188e-01 | 0.233 |
R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.844188e-01 | 0.233 |
R-HSA-9012852 | Signaling by NOTCH3 | 5.844188e-01 | 0.233 |
R-HSA-389948 | Co-inhibition by PD-1 | 5.887029e-01 | 0.230 |
R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.901823e-01 | 0.229 |
R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 5.901823e-01 | 0.229 |
R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.901823e-01 | 0.229 |
R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 5.958661e-01 | 0.225 |
R-HSA-9824443 | Parasitic Infection Pathways | 6.042766e-01 | 0.219 |
R-HSA-9658195 | Leishmania infection | 6.042766e-01 | 0.219 |
R-HSA-352230 | Amino acid transport across the plasma membrane | 6.069996e-01 | 0.217 |
R-HSA-9843745 | Adipogenesis | 6.072617e-01 | 0.217 |
R-HSA-379724 | tRNA Aminoacylation | 6.124512e-01 | 0.213 |
R-HSA-351202 | Metabolism of polyamines | 6.124512e-01 | 0.213 |
R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.124512e-01 | 0.213 |
R-HSA-1442490 | Collagen degradation | 6.178276e-01 | 0.209 |
R-HSA-445717 | Aquaporin-mediated transport | 6.178276e-01 | 0.209 |
R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.178276e-01 | 0.209 |
R-HSA-112043 | PLC beta mediated events | 6.178276e-01 | 0.209 |
R-HSA-9793380 | Formation of paraxial mesoderm | 6.178276e-01 | 0.209 |
R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.231297e-01 | 0.205 |
R-HSA-1268020 | Mitochondrial protein import | 6.231297e-01 | 0.205 |
R-HSA-186797 | Signaling by PDGF | 6.231297e-01 | 0.205 |
R-HSA-8848021 | Signaling by PTK6 | 6.283586e-01 | 0.202 |
R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 6.283586e-01 | 0.202 |
R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.283586e-01 | 0.202 |
R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.386006e-01 | 0.195 |
R-HSA-1234174 | Cellular response to hypoxia | 6.386006e-01 | 0.195 |
R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 6.436158e-01 | 0.191 |
R-HSA-112040 | G-protein mediated events | 6.485617e-01 | 0.188 |
R-HSA-9958863 | SLC-mediated transport of amino acids | 6.485617e-01 | 0.188 |
R-HSA-597592 | Post-translational protein modification | 6.495528e-01 | 0.187 |
R-HSA-8951664 | Neddylation | 6.529976e-01 | 0.185 |
R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.534392e-01 | 0.185 |
R-HSA-5218859 | Regulated Necrosis | 6.534392e-01 | 0.185 |
R-HSA-2871837 | FCERI mediated NF-kB activation | 6.597796e-01 | 0.181 |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 6.629930e-01 | 0.178 |
R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.629930e-01 | 0.178 |
R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.676711e-01 | 0.175 |
R-HSA-453276 | Regulation of mitotic cell cycle | 6.676711e-01 | 0.175 |
R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.676711e-01 | 0.175 |
R-HSA-8978934 | Metabolism of cofactors | 6.676711e-01 | 0.175 |
R-HSA-69052 | Switching of origins to a post-replicative state | 6.768343e-01 | 0.170 |
R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 6.768343e-01 | 0.170 |
R-HSA-9013694 | Signaling by NOTCH4 | 6.813211e-01 | 0.167 |
R-HSA-1236394 | Signaling by ERBB4 | 6.813211e-01 | 0.167 |
R-HSA-72312 | rRNA processing | 6.823471e-01 | 0.166 |
R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.854196e-01 | 0.164 |
R-HSA-3000171 | Non-integrin membrane-ECM interactions | 6.857459e-01 | 0.164 |
R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 6.857459e-01 | 0.164 |
R-HSA-69306 | DNA Replication | 6.885112e-01 | 0.162 |
R-HSA-5689603 | UCH proteinases | 6.901095e-01 | 0.161 |
R-HSA-73887 | Death Receptor Signaling | 6.915779e-01 | 0.160 |
R-HSA-416482 | G alpha (12/13) signalling events | 6.986566e-01 | 0.156 |
R-HSA-5619084 | ABC transporter disorders | 6.986566e-01 | 0.156 |
R-HSA-9659379 | Sensory processing of sound | 7.028417e-01 | 0.153 |
R-HSA-877300 | Interferon gamma signaling | 7.065415e-01 | 0.151 |
R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.069690e-01 | 0.151 |
R-HSA-5654738 | Signaling by FGFR2 | 7.069690e-01 | 0.151 |
R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.069690e-01 | 0.151 |
R-HSA-6806834 | Signaling by MET | 7.069690e-01 | 0.151 |
R-HSA-9006936 | Signaling by TGFB family members | 7.094609e-01 | 0.149 |
R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.190114e-01 | 0.143 |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 7.229151e-01 | 0.141 |
R-HSA-6802957 | Oncogenic MAPK signaling | 7.267647e-01 | 0.139 |
R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.305611e-01 | 0.136 |
R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 7.305611e-01 | 0.136 |
R-HSA-5688426 | Deubiquitination | 7.376834e-01 | 0.132 |
R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 7.411899e-01 | 0.130 |
R-HSA-418555 | G alpha (s) signalling events | 7.426384e-01 | 0.129 |
R-HSA-1236974 | ER-Phagosome pathway | 7.452288e-01 | 0.128 |
R-HSA-5689880 | Ub-specific processing proteases | 7.478431e-01 | 0.126 |
R-HSA-73884 | Base Excision Repair | 7.487697e-01 | 0.126 |
R-HSA-112310 | Neurotransmitter release cycle | 7.487697e-01 | 0.126 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.487697e-01 | 0.126 |
R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.591013e-01 | 0.120 |
R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 7.624503e-01 | 0.118 |
R-HSA-68867 | Assembly of the pre-replicative complex | 7.624503e-01 | 0.118 |
R-HSA-5389840 | Mitochondrial translation elongation | 7.753890e-01 | 0.110 |
R-HSA-5368286 | Mitochondrial translation initiation | 7.815928e-01 | 0.107 |
R-HSA-422356 | Regulation of insulin secretion | 7.815928e-01 | 0.107 |
R-HSA-190236 | Signaling by FGFR | 7.815928e-01 | 0.107 |
R-HSA-168249 | Innate Immune System | 7.817701e-01 | 0.107 |
R-HSA-9614085 | FOXO-mediated transcription | 7.846304e-01 | 0.105 |
R-HSA-382556 | ABC-family proteins mediated transport | 7.876260e-01 | 0.104 |
R-HSA-9020702 | Interleukin-1 signaling | 7.905801e-01 | 0.102 |
R-HSA-9842860 | Regulation of endogenous retroelements | 7.934932e-01 | 0.100 |
R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 7.963661e-01 | 0.099 |
R-HSA-9860931 | Response of endothelial cells to shear stress | 7.991991e-01 | 0.097 |
R-HSA-111885 | Opioid Signalling | 7.991991e-01 | 0.097 |
R-HSA-5673001 | RAF/MAP kinase cascade | 8.052238e-01 | 0.094 |
R-HSA-1236975 | Antigen processing-Cross presentation | 8.127864e-01 | 0.090 |
R-HSA-2672351 | Stimuli-sensing channels | 8.127864e-01 | 0.090 |
R-HSA-5419276 | Mitochondrial translation termination | 8.153919e-01 | 0.089 |
R-HSA-5684996 | MAPK1/MAPK3 signaling | 8.171657e-01 | 0.088 |
R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.278880e-01 | 0.082 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.302843e-01 | 0.081 |
R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 8.349777e-01 | 0.078 |
R-HSA-909733 | Interferon alpha/beta signaling | 8.349777e-01 | 0.078 |
R-HSA-425407 | SLC-mediated transmembrane transport | 8.350693e-01 | 0.078 |
R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.361533e-01 | 0.078 |
R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.439802e-01 | 0.074 |
R-HSA-8878171 | Transcriptional regulation by RUNX1 | 8.577059e-01 | 0.067 |
R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 8.622988e-01 | 0.064 |
R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.637995e-01 | 0.064 |
R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.644046e-01 | 0.063 |
R-HSA-1474244 | Extracellular matrix organization | 8.679557e-01 | 0.062 |
R-HSA-3247509 | Chromatin modifying enzymes | 8.696541e-01 | 0.061 |
R-HSA-1474228 | Degradation of the extracellular matrix | 8.735952e-01 | 0.059 |
R-HSA-9909396 | Circadian clock | 8.735952e-01 | 0.059 |
R-HSA-163685 | Integration of energy metabolism | 8.821655e-01 | 0.054 |
R-HSA-71291 | Metabolism of amino acids and derivatives | 8.823594e-01 | 0.054 |
R-HSA-5368287 | Mitochondrial translation | 8.854294e-01 | 0.053 |
R-HSA-6807070 | PTEN Regulation | 8.870274e-01 | 0.052 |
R-HSA-9664422 | FCGR3A-mediated phagocytosis | 8.886032e-01 | 0.051 |
R-HSA-9664417 | Leishmania phagocytosis | 8.886032e-01 | 0.051 |
R-HSA-9664407 | Parasite infection | 8.886032e-01 | 0.051 |
R-HSA-4839726 | Chromatin organization | 8.896128e-01 | 0.051 |
R-HSA-166520 | Signaling by NTRKs | 9.018364e-01 | 0.045 |
R-HSA-196854 | Metabolism of vitamins and cofactors | 9.040576e-01 | 0.044 |
R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 9.045576e-01 | 0.044 |
R-HSA-416476 | G alpha (q) signalling events | 9.067147e-01 | 0.043 |
R-HSA-9609507 | Protein localization | 9.084992e-01 | 0.042 |
R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.239745e-01 | 0.034 |
R-HSA-388396 | GPCR downstream signalling | 9.287935e-01 | 0.032 |
R-HSA-3781865 | Diseases of glycosylation | 9.416778e-01 | 0.026 |
R-HSA-983712 | Ion channel transport | 9.456452e-01 | 0.024 |
R-HSA-212165 | Epigenetic regulation of gene expression | 9.527407e-01 | 0.021 |
R-HSA-1483206 | Glycerophospholipid biosynthesis | 9.553814e-01 | 0.020 |
R-HSA-372790 | Signaling by GPCR | 9.631864e-01 | 0.016 |
R-HSA-382551 | Transport of small molecules | 9.711179e-01 | 0.013 |
R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 9.771737e-01 | 0.010 |
R-HSA-418594 | G alpha (i) signalling events | 9.829541e-01 | 0.007 |
R-HSA-211945 | Phase I - Functionalization of compounds | 9.847649e-01 | 0.007 |
R-HSA-5668914 | Diseases of metabolism | 9.866649e-01 | 0.006 |
R-HSA-1483257 | Phospholipid metabolism | 9.880284e-01 | 0.005 |
R-HSA-211859 | Biological oxidations | 9.995463e-01 | 0.000 |
R-HSA-500792 | GPCR ligand binding | 9.998249e-01 | 0.000 |
R-HSA-1430728 | Metabolism | 9.999999e-01 | 0.000 |
R-HSA-556833 | Metabolism of lipids | 9.999999e-01 | 0.000 |
R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
Download
kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
---|---|---|---|---|
GAK |
0.863 | 0.071 | 1 | 0.818 |
PKR |
0.852 | 0.074 | 1 | 0.804 |
ALK4 |
0.850 | 0.207 | -2 | 0.885 |
TAK1 |
0.850 | -0.027 | 1 | 0.811 |
PASK |
0.848 | 0.185 | -3 | 0.830 |
DAPK2 |
0.848 | 0.145 | -3 | 0.859 |
GCK |
0.847 | 0.018 | 1 | 0.775 |
EEF2K |
0.847 | 0.036 | 3 | 0.756 |
VRK2 |
0.846 | -0.222 | 1 | 0.844 |
NIK |
0.845 | 0.092 | -3 | 0.876 |
LRRK2 |
0.845 | -0.077 | 2 | 0.826 |
ALK2 |
0.845 | 0.210 | -2 | 0.860 |
TGFBR1 |
0.844 | 0.254 | -2 | 0.860 |
DMPK1 |
0.844 | 0.183 | -3 | 0.764 |
LATS1 |
0.844 | 0.171 | -3 | 0.846 |
TNIK |
0.844 | -0.015 | 3 | 0.772 |
BRAF |
0.843 | -0.034 | -4 | 0.782 |
CAMLCK |
0.843 | 0.124 | -2 | 0.894 |
VRK1 |
0.842 | -0.178 | 2 | 0.771 |
DAPK3 |
0.842 | 0.151 | -3 | 0.793 |
MEK1 |
0.842 | -0.078 | 2 | 0.780 |
MOS |
0.841 | 0.181 | 1 | 0.909 |
BMPR2 |
0.841 | -0.052 | -2 | 0.883 |
MST1 |
0.841 | -0.052 | 1 | 0.755 |
TAO2 |
0.841 | -0.040 | 2 | 0.840 |
MST3 |
0.841 | 0.088 | 2 | 0.838 |
BMPR1B |
0.841 | 0.260 | 1 | 0.896 |
NEK1 |
0.840 | -0.072 | 1 | 0.753 |
MINK |
0.839 | -0.081 | 1 | 0.739 |
KHS2 |
0.839 | 0.036 | 1 | 0.738 |
KHS1 |
0.839 | -0.012 | 1 | 0.713 |
TAO3 |
0.839 | 0.007 | 1 | 0.775 |
TTK |
0.838 | -0.031 | -2 | 0.841 |
CAMK1B |
0.838 | 0.118 | -3 | 0.856 |
HPK1 |
0.838 | 0.009 | 1 | 0.742 |
MST2 |
0.837 | -0.081 | 1 | 0.782 |
ASK1 |
0.837 | -0.167 | 1 | 0.734 |
ROCK2 |
0.837 | 0.169 | -3 | 0.783 |
HGK |
0.836 | -0.057 | 3 | 0.773 |
ACVR2B |
0.836 | 0.186 | -2 | 0.843 |
SMMLCK |
0.835 | 0.092 | -3 | 0.811 |
CAMKK2 |
0.835 | -0.085 | -2 | 0.722 |
LKB1 |
0.834 | -0.074 | -3 | 0.821 |
DAPK1 |
0.834 | 0.156 | -3 | 0.770 |
NEK5 |
0.834 | -0.084 | 1 | 0.786 |
DLK |
0.834 | -0.067 | 1 | 0.857 |
PRPK |
0.834 | -0.060 | -1 | 0.827 |
MEK5 |
0.833 | -0.242 | 2 | 0.779 |
ACVR2A |
0.833 | 0.166 | -2 | 0.837 |
OSR1 |
0.833 | -0.084 | 2 | 0.782 |
ALPHAK3 |
0.833 | -0.081 | -1 | 0.776 |
PDK1 |
0.833 | -0.116 | 1 | 0.756 |
BIKE |
0.832 | -0.026 | 1 | 0.670 |
ANKRD3 |
0.832 | -0.057 | 1 | 0.829 |
YSK1 |
0.832 | -0.028 | 2 | 0.819 |
MEKK2 |
0.832 | -0.161 | 2 | 0.769 |
MAP3K15 |
0.832 | -0.144 | 1 | 0.739 |
GRK7 |
0.831 | 0.184 | 1 | 0.832 |
NEK8 |
0.831 | -0.080 | 2 | 0.800 |
ATR |
0.830 | 0.047 | 1 | 0.831 |
CAMKK1 |
0.830 | -0.142 | -2 | 0.713 |
BMPR1A |
0.830 | 0.225 | 1 | 0.884 |
MYO3B |
0.829 | -0.057 | 2 | 0.832 |
SKMLCK |
0.828 | 0.147 | -2 | 0.901 |
MEKK6 |
0.828 | -0.143 | 1 | 0.752 |
MYO3A |
0.828 | -0.095 | 1 | 0.721 |
CDKL1 |
0.828 | 0.042 | -3 | 0.787 |
NEK4 |
0.827 | -0.121 | 1 | 0.729 |
GRK6 |
0.827 | 0.143 | 1 | 0.904 |
MEKK1 |
0.826 | -0.168 | 1 | 0.780 |
PBK |
0.826 | -0.040 | 1 | 0.707 |
NLK |
0.826 | 0.007 | 1 | 0.787 |
YSK4 |
0.826 | -0.071 | 1 | 0.745 |
LOK |
0.826 | 0.012 | -2 | 0.771 |
PIM1 |
0.825 | 0.173 | -3 | 0.771 |
CAMK2G |
0.825 | 0.120 | 2 | 0.786 |
CLK3 |
0.825 | 0.249 | 1 | 0.816 |
MEK2 |
0.825 | -0.218 | 2 | 0.754 |
NEK11 |
0.825 | -0.162 | 1 | 0.767 |
MPSK1 |
0.825 | -0.034 | 1 | 0.726 |
MRCKA |
0.825 | 0.181 | -3 | 0.754 |
ICK |
0.824 | 0.035 | -3 | 0.819 |
ZAK |
0.823 | -0.120 | 1 | 0.777 |
MEKK3 |
0.822 | -0.159 | 1 | 0.788 |
ROCK1 |
0.822 | 0.136 | -3 | 0.754 |
PLK1 |
0.821 | 0.051 | -2 | 0.810 |
STLK3 |
0.821 | -0.239 | 1 | 0.736 |
PIM3 |
0.821 | 0.158 | -3 | 0.820 |
GRK5 |
0.821 | 0.032 | -3 | 0.836 |
CDC7 |
0.820 | 0.213 | 1 | 0.914 |
RAF1 |
0.820 | -0.056 | 1 | 0.821 |
P70S6KB |
0.820 | 0.155 | -3 | 0.794 |
PERK |
0.819 | -0.069 | -2 | 0.845 |
COT |
0.819 | 0.145 | 2 | 0.821 |
AAK1 |
0.819 | 0.002 | 1 | 0.549 |
GSK3B |
0.818 | 0.202 | 4 | 0.616 |
WNK1 |
0.818 | 0.117 | -2 | 0.877 |
PIM2 |
0.818 | 0.129 | -3 | 0.741 |
MST4 |
0.817 | 0.160 | 2 | 0.877 |
PKN3 |
0.817 | 0.078 | -3 | 0.812 |
PKCD |
0.817 | 0.143 | 2 | 0.797 |
SLK |
0.817 | 0.009 | -2 | 0.714 |
CRIK |
0.817 | 0.125 | -3 | 0.695 |
HRI |
0.817 | -0.111 | -2 | 0.863 |
DRAK1 |
0.817 | 0.102 | 1 | 0.862 |
MRCKB |
0.817 | 0.145 | -3 | 0.738 |
GSK3A |
0.817 | 0.217 | 4 | 0.624 |
JNK2 |
0.816 | 0.001 | 1 | 0.566 |
RSK2 |
0.816 | 0.219 | -3 | 0.768 |
DCAMKL1 |
0.816 | 0.067 | -3 | 0.789 |
JNK3 |
0.816 | -0.020 | 1 | 0.605 |
TLK2 |
0.815 | -0.035 | 1 | 0.776 |
MLK2 |
0.814 | -0.142 | 2 | 0.801 |
CHAK2 |
0.814 | 0.044 | -1 | 0.855 |
TLK1 |
0.813 | -0.055 | -2 | 0.852 |
MLK1 |
0.812 | -0.063 | 2 | 0.808 |
NEK2 |
0.812 | -0.002 | 2 | 0.813 |
AMPKA1 |
0.812 | 0.049 | -3 | 0.848 |
PKN2 |
0.812 | 0.109 | -3 | 0.838 |
NEK9 |
0.812 | -0.099 | 2 | 0.823 |
GRK2 |
0.812 | 0.053 | -2 | 0.737 |
TAO1 |
0.812 | -0.103 | 1 | 0.672 |
SGK3 |
0.811 | 0.134 | -3 | 0.758 |
MYLK4 |
0.811 | 0.130 | -2 | 0.845 |
PDHK4 |
0.811 | -0.193 | 1 | 0.831 |
CAMK2A |
0.811 | 0.207 | 2 | 0.784 |
DSTYK |
0.811 | 0.052 | 2 | 0.852 |
P38A |
0.810 | -0.040 | 1 | 0.632 |
WNK4 |
0.810 | -0.101 | -2 | 0.858 |
CAMK2B |
0.810 | 0.177 | 2 | 0.754 |
BUB1 |
0.810 | 0.059 | -5 | 0.769 |
PRP4 |
0.809 | -0.078 | -3 | 0.737 |
CLK4 |
0.809 | 0.140 | -3 | 0.760 |
DCAMKL2 |
0.809 | 0.030 | -3 | 0.815 |
TSSK2 |
0.809 | -0.014 | -5 | 0.815 |
ERK5 |
0.808 | -0.047 | 1 | 0.737 |
RSK4 |
0.808 | 0.220 | -3 | 0.733 |
CAMK2D |
0.808 | 0.086 | -3 | 0.832 |
PLK3 |
0.808 | 0.020 | 2 | 0.694 |
TGFBR2 |
0.807 | 0.090 | -2 | 0.853 |
RIPK3 |
0.806 | -0.037 | 3 | 0.685 |
P38B |
0.806 | -0.026 | 1 | 0.571 |
RIPK1 |
0.806 | -0.150 | 1 | 0.782 |
CHK1 |
0.806 | -0.022 | -3 | 0.828 |
AKT2 |
0.806 | 0.111 | -3 | 0.682 |
MASTL |
0.806 | -0.276 | -2 | 0.791 |
SGK1 |
0.806 | 0.121 | -3 | 0.601 |
MLK3 |
0.806 | 0.012 | 2 | 0.761 |
HIPK1 |
0.805 | 0.025 | 1 | 0.649 |
NUAK2 |
0.805 | 0.025 | -3 | 0.832 |
CDKL5 |
0.805 | 0.035 | -3 | 0.777 |
P90RSK |
0.805 | 0.123 | -3 | 0.762 |
GRK1 |
0.805 | 0.148 | -2 | 0.777 |
PKCA |
0.805 | 0.132 | 2 | 0.757 |
PDHK1 |
0.805 | -0.218 | 1 | 0.803 |
DNAPK |
0.804 | 0.048 | 1 | 0.655 |
HASPIN |
0.804 | -0.045 | -1 | 0.651 |
IRAK4 |
0.804 | -0.106 | 1 | 0.740 |
ATM |
0.803 | 0.031 | 1 | 0.777 |
AURB |
0.803 | 0.178 | -2 | 0.769 |
MLK4 |
0.803 | -0.046 | 2 | 0.727 |
ERK7 |
0.803 | 0.105 | 2 | 0.648 |
MTOR |
0.802 | -0.039 | 1 | 0.752 |
MSK1 |
0.802 | 0.169 | -3 | 0.735 |
PAK1 |
0.802 | 0.107 | -2 | 0.845 |
PKCH |
0.801 | 0.087 | 2 | 0.727 |
CHAK1 |
0.801 | -0.073 | 2 | 0.753 |
AMPKA2 |
0.801 | 0.043 | -3 | 0.821 |
TSSK1 |
0.801 | 0.020 | -3 | 0.866 |
MARK4 |
0.800 | -0.011 | 4 | 0.838 |
MAK |
0.800 | 0.048 | -2 | 0.759 |
CAMK4 |
0.800 | 0.034 | -3 | 0.818 |
NDR1 |
0.800 | 0.113 | -3 | 0.831 |
CAMK1D |
0.800 | 0.060 | -3 | 0.678 |
NEK7 |
0.799 | -0.054 | -3 | 0.840 |
HUNK |
0.799 | -0.130 | 2 | 0.723 |
CDK1 |
0.799 | 0.014 | 1 | 0.608 |
SMG1 |
0.798 | 0.001 | 1 | 0.769 |
PKACG |
0.798 | 0.178 | -2 | 0.832 |
AKT1 |
0.798 | 0.122 | -3 | 0.704 |
CLK1 |
0.798 | 0.135 | -3 | 0.747 |
NEK6 |
0.798 | 0.032 | -2 | 0.857 |
CK2A2 |
0.798 | 0.252 | 1 | 0.868 |
PAK2 |
0.797 | 0.037 | -2 | 0.828 |
PLK2 |
0.797 | 0.047 | -3 | 0.783 |
PKCB |
0.797 | 0.100 | 2 | 0.756 |
NEK3 |
0.797 | -0.184 | 1 | 0.694 |
P38G |
0.797 | -0.027 | 1 | 0.504 |
WNK3 |
0.796 | -0.150 | 1 | 0.779 |
PKCE |
0.796 | 0.132 | 2 | 0.742 |
JNK1 |
0.796 | -0.030 | 1 | 0.579 |
RSK3 |
0.796 | 0.135 | -3 | 0.759 |
ERK2 |
0.796 | -0.072 | 1 | 0.604 |
PKCZ |
0.796 | 0.046 | 2 | 0.781 |
MOK |
0.796 | 0.012 | 1 | 0.643 |
CLK2 |
0.796 | 0.199 | -3 | 0.742 |
CDK5 |
0.796 | -0.016 | 1 | 0.646 |
ULK2 |
0.795 | -0.117 | 2 | 0.743 |
PINK1 |
0.795 | -0.191 | 1 | 0.774 |
PKACB |
0.795 | 0.208 | -2 | 0.788 |
PKG2 |
0.795 | 0.170 | -2 | 0.792 |
AURC |
0.795 | 0.227 | -2 | 0.775 |
PKCG |
0.795 | 0.094 | 2 | 0.750 |
MNK1 |
0.794 | 0.156 | -2 | 0.864 |
AURA |
0.794 | 0.152 | -2 | 0.741 |
SRPK3 |
0.794 | 0.027 | -3 | 0.705 |
SRPK1 |
0.793 | 0.070 | -3 | 0.735 |
CAMK1G |
0.793 | 0.036 | -3 | 0.756 |
CDK14 |
0.793 | 0.007 | 1 | 0.597 |
NDR2 |
0.793 | 0.165 | -3 | 0.831 |
MAPKAPK3 |
0.792 | 0.021 | -3 | 0.772 |
MELK |
0.792 | -0.011 | -3 | 0.809 |
IRE2 |
0.792 | -0.060 | 2 | 0.727 |
DYRK2 |
0.792 | -0.020 | 1 | 0.634 |
CHK2 |
0.792 | 0.006 | -3 | 0.635 |
LATS2 |
0.791 | 0.103 | -5 | 0.775 |
PAK3 |
0.791 | 0.049 | -2 | 0.833 |
GRK4 |
0.791 | -0.060 | -2 | 0.826 |
CDK2 |
0.790 | -0.041 | 1 | 0.713 |
IRE1 |
0.790 | -0.086 | 1 | 0.741 |
HIPK4 |
0.790 | 0.014 | 1 | 0.727 |
CK2A1 |
0.789 | 0.238 | 1 | 0.856 |
DYRK1A |
0.789 | -0.026 | 1 | 0.677 |
PKCI |
0.789 | 0.087 | 2 | 0.765 |
MSK2 |
0.789 | 0.075 | -3 | 0.722 |
TTBK2 |
0.789 | -0.157 | 2 | 0.660 |
P70S6K |
0.789 | 0.080 | -3 | 0.704 |
PRKD3 |
0.788 | 0.040 | -3 | 0.744 |
TBK1 |
0.788 | -0.182 | 1 | 0.690 |
ERK1 |
0.788 | -0.042 | 1 | 0.550 |
P38D |
0.788 | -0.035 | 1 | 0.495 |
HIPK3 |
0.787 | -0.043 | 1 | 0.624 |
CDK10 |
0.787 | 0.069 | 1 | 0.581 |
PDHK3_TYR |
0.787 | 0.321 | 4 | 0.899 |
MNK2 |
0.787 | 0.129 | -2 | 0.853 |
MAPKAPK2 |
0.787 | 0.097 | -3 | 0.728 |
PRKD1 |
0.786 | 0.063 | -3 | 0.815 |
PRKX |
0.786 | 0.267 | -3 | 0.680 |
QIK |
0.786 | -0.066 | -3 | 0.828 |
PRKD2 |
0.786 | 0.126 | -3 | 0.770 |
SSTK |
0.785 | 0.005 | 4 | 0.795 |
CDK16 |
0.785 | 0.024 | 1 | 0.533 |
PKACA |
0.785 | 0.176 | -2 | 0.754 |
GRK3 |
0.785 | 0.038 | -2 | 0.702 |
MARK2 |
0.784 | -0.026 | 4 | 0.747 |
CDK6 |
0.784 | -0.035 | 1 | 0.561 |
QSK |
0.783 | 0.004 | 4 | 0.812 |
CAMK1A |
0.783 | 0.039 | -3 | 0.658 |
PKCT |
0.783 | 0.037 | 2 | 0.736 |
DYRK3 |
0.783 | 0.017 | 1 | 0.645 |
DYRK1B |
0.783 | -0.019 | 1 | 0.590 |
MARK3 |
0.783 | 0.017 | 4 | 0.783 |
CDK4 |
0.782 | -0.041 | 1 | 0.553 |
STK33 |
0.782 | -0.116 | 2 | 0.565 |
IKKB |
0.782 | -0.111 | -2 | 0.725 |
GCN2 |
0.782 | -0.077 | 2 | 0.780 |
MARK1 |
0.782 | -0.033 | 4 | 0.794 |
RIPK2 |
0.782 | -0.252 | 1 | 0.718 |
CDK3 |
0.781 | -0.001 | 1 | 0.534 |
IRAK1 |
0.781 | -0.319 | -1 | 0.698 |
AKT3 |
0.780 | 0.117 | -3 | 0.616 |
CDK17 |
0.780 | -0.022 | 1 | 0.517 |
IKKE |
0.780 | -0.205 | 1 | 0.680 |
ULK1 |
0.780 | -0.137 | -3 | 0.807 |
NIM1 |
0.779 | -0.093 | 3 | 0.696 |
HIPK2 |
0.779 | 0.025 | 1 | 0.540 |
SRPK2 |
0.779 | 0.076 | -3 | 0.660 |
SBK |
0.778 | 0.012 | -3 | 0.568 |
CDK18 |
0.778 | -0.003 | 1 | 0.556 |
PDHK4_TYR |
0.778 | 0.139 | 2 | 0.828 |
IKKA |
0.777 | -0.037 | -2 | 0.709 |
CDK7 |
0.777 | -0.044 | 1 | 0.625 |
CDK13 |
0.777 | -0.060 | 1 | 0.591 |
SIK |
0.776 | 0.008 | -3 | 0.761 |
TESK1_TYR |
0.776 | 0.048 | 3 | 0.800 |
DYRK4 |
0.775 | -0.006 | 1 | 0.566 |
NUAK1 |
0.775 | -0.026 | -3 | 0.790 |
CDK8 |
0.774 | -0.057 | 1 | 0.622 |
MAP2K4_TYR |
0.774 | 0.034 | -1 | 0.844 |
CDK9 |
0.774 | -0.059 | 1 | 0.592 |
BMPR2_TYR |
0.774 | 0.067 | -1 | 0.833 |
PHKG1 |
0.773 | -0.006 | -3 | 0.821 |
CDK12 |
0.773 | -0.062 | 1 | 0.561 |
MAP2K6_TYR |
0.773 | 0.043 | -1 | 0.845 |
PDHK1_TYR |
0.772 | 0.043 | -1 | 0.865 |
PLK4 |
0.771 | -0.166 | 2 | 0.542 |
BCKDK |
0.771 | -0.196 | -1 | 0.742 |
PKMYT1_TYR |
0.768 | -0.077 | 3 | 0.770 |
MAP2K7_TYR |
0.768 | -0.140 | 2 | 0.805 |
PAK6 |
0.768 | 0.119 | -2 | 0.771 |
CK1D |
0.768 | -0.050 | -3 | 0.443 |
EPHA6 |
0.768 | 0.050 | -1 | 0.836 |
PKN1 |
0.767 | 0.020 | -3 | 0.722 |
PINK1_TYR |
0.767 | -0.108 | 1 | 0.840 |
BRSK1 |
0.766 | -0.016 | -3 | 0.787 |
LIMK2_TYR |
0.766 | 0.008 | -3 | 0.891 |
YANK3 |
0.765 | -0.058 | 2 | 0.362 |
CK1A2 |
0.765 | -0.038 | -3 | 0.442 |
TTBK1 |
0.765 | -0.158 | 2 | 0.573 |
FAM20C |
0.763 | 0.032 | 2 | 0.540 |
MAPKAPK5 |
0.763 | -0.098 | -3 | 0.705 |
SNRK |
0.762 | -0.177 | 2 | 0.614 |
EPHB4 |
0.761 | -0.024 | -1 | 0.819 |
BRSK2 |
0.761 | -0.076 | -3 | 0.813 |
TXK |
0.761 | 0.091 | 1 | 0.934 |
CK1E |
0.760 | -0.041 | -3 | 0.496 |
PHKG2 |
0.759 | 0.001 | -3 | 0.809 |
LIMK1_TYR |
0.758 | -0.164 | 2 | 0.815 |
CDK19 |
0.758 | -0.061 | 1 | 0.577 |
RET |
0.757 | -0.158 | 1 | 0.774 |
DDR1 |
0.756 | -0.115 | 4 | 0.827 |
EPHA4 |
0.756 | -0.013 | 2 | 0.698 |
FGR |
0.755 | -0.107 | 1 | 0.864 |
YES1 |
0.754 | -0.080 | -1 | 0.816 |
SRMS |
0.754 | -0.043 | 1 | 0.905 |
FER |
0.753 | -0.122 | 1 | 0.907 |
YANK2 |
0.753 | -0.092 | 2 | 0.380 |
MST1R |
0.753 | -0.195 | 3 | 0.710 |
PAK5 |
0.752 | 0.063 | -2 | 0.717 |
ROS1 |
0.752 | -0.183 | 3 | 0.671 |
EPHB1 |
0.752 | -0.060 | 1 | 0.880 |
TYRO3 |
0.751 | -0.198 | 3 | 0.695 |
TYK2 |
0.751 | -0.266 | 1 | 0.761 |
ABL2 |
0.750 | -0.095 | -1 | 0.795 |
TNK2 |
0.750 | -0.072 | 3 | 0.674 |
INSRR |
0.749 | -0.115 | 3 | 0.666 |
JAK3 |
0.748 | -0.162 | 1 | 0.775 |
EPHB2 |
0.748 | -0.061 | -1 | 0.800 |
FGFR2 |
0.748 | -0.137 | 3 | 0.730 |
ABL1 |
0.748 | -0.103 | -1 | 0.786 |
CSF1R |
0.747 | -0.202 | 3 | 0.688 |
EPHB3 |
0.747 | -0.099 | -1 | 0.798 |
JAK2 |
0.747 | -0.261 | 1 | 0.758 |
KDR |
0.747 | -0.107 | 3 | 0.665 |
BLK |
0.747 | -0.035 | -1 | 0.804 |
ITK |
0.746 | -0.098 | -1 | 0.760 |
HCK |
0.746 | -0.146 | -1 | 0.791 |
LCK |
0.746 | -0.085 | -1 | 0.793 |
TNNI3K_TYR |
0.745 | -0.056 | 1 | 0.773 |
PDGFRB |
0.744 | -0.191 | 3 | 0.700 |
TEC |
0.744 | -0.062 | -1 | 0.719 |
BMX |
0.744 | -0.057 | -1 | 0.709 |
EPHA7 |
0.744 | -0.055 | 2 | 0.700 |
FLT1 |
0.743 | -0.078 | -1 | 0.816 |
MERTK |
0.743 | -0.104 | 3 | 0.685 |
AXL |
0.742 | -0.145 | 3 | 0.690 |
KIS |
0.742 | -0.035 | 1 | 0.631 |
PKG1 |
0.742 | 0.069 | -2 | 0.726 |
PAK4 |
0.742 | 0.066 | -2 | 0.727 |
EPHA3 |
0.741 | -0.105 | 2 | 0.674 |
FYN |
0.741 | -0.057 | -1 | 0.766 |
NEK10_TYR |
0.741 | -0.127 | 1 | 0.620 |
KIT |
0.741 | -0.202 | 3 | 0.694 |
MET |
0.741 | -0.152 | 3 | 0.683 |
JAK1 |
0.740 | -0.123 | 1 | 0.696 |
WEE1_TYR |
0.740 | -0.107 | -1 | 0.719 |
FGFR1 |
0.739 | -0.214 | 3 | 0.680 |
DDR2 |
0.739 | -0.040 | 3 | 0.663 |
PTK2B |
0.739 | -0.039 | -1 | 0.745 |
TNK1 |
0.738 | -0.150 | 3 | 0.676 |
LTK |
0.738 | -0.152 | 3 | 0.644 |
NTRK1 |
0.738 | -0.185 | -1 | 0.786 |
FLT3 |
0.738 | -0.229 | 3 | 0.687 |
EPHA5 |
0.737 | -0.055 | 2 | 0.671 |
EGFR |
0.737 | -0.045 | 1 | 0.739 |
ALK |
0.737 | -0.180 | 3 | 0.618 |
FGFR3 |
0.737 | -0.155 | 3 | 0.700 |
ERBB2 |
0.736 | -0.163 | 1 | 0.797 |
PTK2 |
0.736 | 0.019 | -1 | 0.756 |
PTK6 |
0.736 | -0.214 | -1 | 0.700 |
TEK |
0.736 | -0.234 | 3 | 0.644 |
FLT4 |
0.735 | -0.171 | 3 | 0.680 |
PDGFRA |
0.735 | -0.270 | 3 | 0.698 |
SYK |
0.735 | 0.009 | -1 | 0.756 |
EPHA8 |
0.734 | -0.086 | -1 | 0.784 |
EPHA1 |
0.733 | -0.156 | 3 | 0.658 |
BTK |
0.733 | -0.241 | -1 | 0.727 |
NTRK2 |
0.733 | -0.214 | 3 | 0.672 |
FRK |
0.733 | -0.140 | -1 | 0.812 |
MATK |
0.733 | -0.126 | -1 | 0.738 |
NTRK3 |
0.733 | -0.150 | -1 | 0.745 |
LYN |
0.730 | -0.177 | 3 | 0.627 |
INSR |
0.729 | -0.213 | 3 | 0.639 |
SRC |
0.729 | -0.132 | -1 | 0.774 |
CSK |
0.727 | -0.164 | 2 | 0.705 |
EPHA2 |
0.725 | -0.078 | -1 | 0.762 |
FGFR4 |
0.725 | -0.126 | -1 | 0.768 |
ERBB4 |
0.723 | -0.048 | 1 | 0.781 |
CK1G1 |
0.723 | -0.102 | -3 | 0.494 |
MUSK |
0.721 | -0.118 | 1 | 0.701 |
IGF1R |
0.717 | -0.176 | 3 | 0.586 |
CK1G3 |
0.717 | -0.095 | -3 | 0.304 |
FES |
0.707 | -0.151 | -1 | 0.685 |
CK1G2 |
0.704 | -0.068 | -3 | 0.405 |
ZAP70 |
0.702 | -0.084 | -1 | 0.683 |
CK1A |
0.700 | -0.048 | -3 | 0.353 |