Motif 107 (n=213)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2VDJ0 | TMEM131L | S1007 | ochoa | Transmembrane protein 131-like | [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. {ECO:0000269|PubMed:23690469}. |
| A5PLL1 | ANKRD34B | S228 | ochoa | Ankyrin repeat domain-containing protein 34B | None |
| A6NHT5 | HMX3 | S144 | ochoa | Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1) | Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity). {ECO:0000250}. |
| K7ERQ8 | None | S124 | ochoa | PCAF N-terminal domain-containing protein | None |
| O15027 | SEC16A | S1841 | psp | Protein transport protein Sec16A (SEC16 homolog A) (p250) | Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17005010, PubMed:17192411, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity). {ECO:0000250|UniProtKB:E9QAT4, ECO:0000269|PubMed:17005010, ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:17428803, ECO:0000269|PubMed:21768384, ECO:0000269|PubMed:22355596, ECO:0000269|PubMed:28067262, ECO:0000269|PubMed:28442536, ECO:0000269|PubMed:29300766}. |
| O15055 | PER2 | S627 | ochoa | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes. First, interacts directly with the CLOCK-BMAL1 at the tail end of the nascent transcript peak to recruit complexes containing the SIN3-HDAC that remodel chromatin to repress transcription. Second, brings H3K9 methyltransferases such as SUV39H1 and SUV39H2 to the E-box elements of the circadian target genes, like PER2 itself or PER1. The recruitment of each repressive modifier to the DNA seems to be very precisely temporally orchestrated by the large PER complex, the deacetylases acting before than the methyltransferases. Additionally, large PER complexes are also recruited to the target genes 3' termination site through interactions with RNA-binding proteins and helicases that may play a role in transcription termination to regulate transcription independently of CLOCK-BMAL1 interactions. Recruitment of large PER complexes to the elongating polymerase at PER and CRY termination sites inhibited SETX action, impeding RNA polymerase II release and thereby repressing transcriptional reinitiation. May propagate clock information to metabolic pathways via the interaction with nuclear receptors. Coactivator of PPARA and corepressor of NR1D1, binds rhythmically at the promoter of nuclear receptors target genes like BMAL1 or G6PC1. Directly and specifically represses PPARG proadipogenic activity by blocking PPARG recruitment to target promoters and thereby inhibiting transcriptional activation. Required for fatty acid and lipid metabolism, is involved as well in the regulation of circulating insulin levels. Plays an important role in the maintenance of cardiovascular functions through the regulation of NO and vasodilatatory prostaglandins production in aortas. Controls circadian glutamate uptake in synaptic vesicles through the regulation of VGLUT1 expression. May also be involved in the regulation of inflammatory processes. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and ATF4. Negatively regulates the formation of the TIMELESS-CRY1 complex by competing with TIMELESS for binding to CRY1. {ECO:0000250|UniProtKB:O54943}. |
| O15061 | SYNM | S429 | ochoa|psp | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15151 | MDM4 | S20 | ochoa | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}. |
| O43166 | SIPA1L1 | S1255 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43172 | PRPF4 | S240 | ochoa | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:28781166}. |
| O43379 | WDR62 | S1388 | ochoa | WD repeat-containing protein 62 | Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| O43491 | EPB41L2 | S908 | ochoa | Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) | Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| O60333 | KIF1B | S1432 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60732 | MAGEC1 | S217 | ochoa | Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen) | None |
| O75132 | ZBED4 | S297 | ochoa | Zinc finger BED domain-containing protein 4 | Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity). {ECO:0000250|UniProtKB:Q80WQ9}. |
| O75376 | NCOR1 | S1263 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | S2202 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O94913 | PCF11 | S728 | ochoa | Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. {ECO:0000269|PubMed:11060040, ECO:0000269|PubMed:29196535}. |
| O94916 | NFAT5 | S434 | ochoa | Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP) | Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076}. |
| O95630 | STAMBP | S48 | psp | STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). {ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699, ECO:0000269|PubMed:34425109}. |
| O96019 | ACTL6A | S195 | psp | Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| P00533 | EGFR | S1153 | ochoa | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P04150 | NR3C1 | S203 | ochoa|psp | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P06401 | PGR | S676 | psp | Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9407067, ECO:0000305}.; FUNCTION: [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. {ECO:0000269|PubMed:7969170, ECO:0000269|PubMed:8180103, ECO:0000269|PubMed:8264658, ECO:0000305, ECO:0000305|PubMed:10757795}.; FUNCTION: [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.; FUNCTION: [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. |
| P09874 | PARP1 | S41 | ochoa | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18055453, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:20388712, PubMed:21680843, PubMed:22582261, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:26626479, PubMed:26626480, PubMed:30104678, PubMed:31796734, PubMed:32028527, PubMed:32241924, PubMed:32358582, PubMed:33186521, PubMed:34465625, PubMed:34737271). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539, PubMed:7852410, PubMed:9315851). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:33589610, PubMed:34625544, PubMed:34874266). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:29954836, PubMed:30257210). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34465625, PubMed:34874266). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:33683197, PubMed:34732825, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:15607977, PubMed:17177976, PubMed:19344625, PubMed:27256882, PubMed:32315358, PubMed:32844745, PubMed:35124853, PubMed:35393539, PubMed:35460603). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32315358, PubMed:32844745, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000250|UniProtKB:P11103, ECO:0000269|PubMed:15607977, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18055453, ECO:0000269|PubMed:18172500, ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:19764761, ECO:0000269|PubMed:20388712, ECO:0000269|PubMed:21680843, ECO:0000269|PubMed:22464733, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24906880, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:26344098, ECO:0000269|PubMed:26626479, ECO:0000269|PubMed:26626480, ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:27256882, ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:27471034, ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30257210, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:31796734, ECO:0000269|PubMed:32028527, ECO:0000269|PubMed:32241924, ECO:0000269|PubMed:32315358, ECO:0000269|PubMed:32358582, ECO:0000269|PubMed:32844745, ECO:0000269|PubMed:33186521, ECO:0000269|PubMed:33412112, ECO:0000269|PubMed:33589610, ECO:0000269|PubMed:33683197, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:34465625, ECO:0000269|PubMed:34625544, ECO:0000269|PubMed:34732825, ECO:0000269|PubMed:34737271, ECO:0000269|PubMed:34795260, ECO:0000269|PubMed:34874266, ECO:0000269|PubMed:35124853, ECO:0000269|PubMed:35393539, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:7852410, ECO:0000269|PubMed:9315851}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed C-terminus]: Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626). {ECO:0000269|PubMed:33168626}.; FUNCTION: [Poly [ADP-ribose] polymerase 1, processed N-terminus]: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. {ECO:0000269|PubMed:35104452}. |
| P0DI81 | TRAPPC2 | S119 | ochoa | Trafficking protein particle complex subunit 2 (Sedlin) | Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000250}. |
| P0DI82 | TRAPPC2B | S119 | ochoa | Trafficking protein particle complex subunit 2B (MBP-1-interacting protein 2A) (MIP-2A) | Prevents transcriptional repression and induction of cell death by ENO1. May play a role in vesicular transport from endoplasmic reticulum to Golgi. {ECO:0000269|PubMed:11134351}. |
| P10071 | GLI3 | S45 | ochoa | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] | Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269|PubMed:10693759, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:17764085}. |
| P10244 | MYBL2 | S452 | ochoa|psp | Myb-related protein B (B-Myb) (Myb-like protein 2) | Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
| P10914 | IRF1 | S282 | ochoa | Interferon regulatory factor 1 (IRF-1) | Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:32385160). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:21389130, PubMed:22367195). Has an essentail role in IFNG-dependent immunity to mycobacteria (PubMed:36736301). Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters (PubMed:32385160). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (PubMed:18641303, PubMed:22200613). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (PubMed:15509808, PubMed:18084608). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (PubMed:20049431). {ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:15509808, ECO:0000269|PubMed:17516545, ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:18084608, ECO:0000269|PubMed:18497060, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:19404407, ECO:0000269|PubMed:19851330, ECO:0000269|PubMed:21389130, ECO:0000269|PubMed:22200613, ECO:0000269|PubMed:22367195, ECO:0000269|PubMed:32385160, ECO:0000269|PubMed:36736301, ECO:0000303|PubMed:11244049, ECO:0000303|PubMed:11846971, ECO:0000303|PubMed:11846974, ECO:0000303|PubMed:16932750, ECO:0000303|PubMed:20049431}. |
| P11137 | MAP2 | S610 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P15822 | HIVEP1 | S2599 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16157 | ANK1 | S1686 | ochoa | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}. |
| P17098 | ZNF8 | S223 | ochoa | Zinc finger protein 8 (Zinc finger protein HF.18) | Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. {ECO:0000250|UniProtKB:Q8BGV5}. |
| P17600 | SYN1 | S341 | ochoa | Synapsin-1 (Brain protein 4.1) (Synapsin I) | Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247, PubMed:23406870). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). {ECO:0000250|UniProtKB:O88935, ECO:0000250|UniProtKB:P09951, ECO:0000269|PubMed:21441247, ECO:0000269|PubMed:23406870}. |
| P17707 | AMD1 | S298 | ochoa|psp | S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] | Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}. |
| P18146 | EGR1 | S26 | ochoa|psp | Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24) | Transcriptional regulator (PubMed:20121949). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity). {ECO:0000250|UniProtKB:P08046, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311}. |
| P18583 | SON | S283 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19878 | NCF2 | S332 | ochoa | Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) | Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:12207919, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P14598, ECO:0000269|PubMed:12207919, ECO:0000269|PubMed:38355798}. |
| P20339 | RAB5A | S123 | ochoa|psp | Ras-related protein Rab-5A (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:15378032, PubMed:16410077). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity). {ECO:0000250|UniProtKB:Q9CQD1, ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077, ECO:0000269|PubMed:22660413}. |
| P22670 | RFX1 | S159 | ochoa | MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1) | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. |
| P26378 | ELAVL4 | S228 | ochoa | ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) | RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:7898713). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636). {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:Q61701, ECO:0000269|PubMed:10710437, ECO:0000269|PubMed:12034726, ECO:0000269|PubMed:12468554, ECO:0000269|PubMed:17035636, ECO:0000269|PubMed:17234598, ECO:0000269|PubMed:18218628, ECO:0000269|PubMed:24857657, ECO:0000269|PubMed:7898713}. |
| P28749 | RBL1 | S1041 | ochoa | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904). {ECO:0000250|UniProtKB:Q64701, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:8319904}. |
| P30153 | PPP2R1A | S120 | ochoa | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2Aa) (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed:33243860, PubMed:33633399, PubMed:34004147, PubMed:8694763). Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:18782753, PubMed:33633399). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753, PubMed:33633399). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for PPP2CA, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (PubMed:33243860, PubMed:34004147). Regulates the recruitment of the SKA complex to kinetochores (PubMed:28982702). {ECO:0000250|UniProtKB:Q76MZ3, ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:28982702, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:33633399, ECO:0000269|PubMed:34004147, ECO:0000269|PubMed:8694763}. |
| P35270 | SPR | S145 | ochoa | Sepiapterin reductase (SPR) (EC 1.1.1.153) | Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. |
| P35548 | MSX2 | S91 | ochoa | Homeobox protein MSX-2 (Homeobox protein Hox-8) | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}. |
| P37275 | ZEB1 | S447 | ochoa | Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8) | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity). {ECO:0000250|UniProtKB:Q64318, ECO:0000269|PubMed:19935649, ECO:0000269|PubMed:20175752, ECO:0000269|PubMed:20418909}. |
| P39880 | CUX1 | S1059 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P41586 | ADCYAP1R1 | S447 | ochoa | Pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1 receptor) (PAC1R) (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) | G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides (PubMed:32047270, PubMed:35477937, PubMed:36385145). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (PubMed:32047270, PubMed:33715378). {ECO:0000269|PubMed:32047270, ECO:0000269|PubMed:33715378, ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145}. |
| P42566 | EPS15 | S324 | ochoa | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| P42858 | HTT | S2074 | psp | Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| P49959 | MRE11 | S165 | ochoa | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}. |
| P51148 | RAB5C | S124 | ochoa | Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P51610 | HCFC1 | S666 | ochoa | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | Transcriptional coregulator (By similarity). Serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators (PubMed:26416877). Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity). {ECO:0000250|UniProtKB:D3ZN95, ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:10675337, ECO:0000269|PubMed:10779346, ECO:0000269|PubMed:12244100, ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:14532282, ECO:0000269|PubMed:15190068, ECO:0000269|PubMed:16624878, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:26416877}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000269|PubMed:10629049, ECO:0000269|PubMed:17578910}. |
| P55197 | MLLT10 | S519 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P57059 | SIK1 | S516 | ochoa | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
| P59923 | ZNF445 | S927 | ochoa | Zinc finger protein 445 (ZFP445) (Zinc finger protein 168) (Zinc finger protein with KRAB and SCAN domains 15) | Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:30602440). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). {ECO:0000269|PubMed:30602440}. |
| P61020 | RAB5B | S123 | ochoa|psp | Ras-related protein Rab-5B (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20339}. |
| P63244 | RACK1 | S157 | ochoa | Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)] | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:12589061, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17108144, ECO:0000269|PubMed:17244529, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:18088317, ECO:0000269|PubMed:18258429, ECO:0000269|PubMed:18621736, ECO:0000269|PubMed:19423701, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20541605, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:21212275, ECO:0000269|PubMed:21347310, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:28132843, ECO:0000269|PubMed:9584165}.; FUNCTION: (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {ECO:0000269|PubMed:21347310}.; FUNCTION: (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {ECO:0000269|PubMed:11312657}.; FUNCTION: (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {ECO:0000269|PubMed:28636603}.; FUNCTION: (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269|PubMed:25416947}. |
| Q00613 | HSF1 | S275 | ochoa|psp | Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) | Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925). {ECO:0000269|PubMed:10359787, ECO:0000269|PubMed:11447121, ECO:0000269|PubMed:11583998, ECO:0000269|PubMed:12659875, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:14707147, ECO:0000269|PubMed:15016915, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:1871105, ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:1986252, ECO:0000269|PubMed:25963659, ECO:0000269|PubMed:26359349, ECO:0000269|PubMed:26727489, ECO:0000269|PubMed:26754925, ECO:0000269|PubMed:34723967, ECO:0000269|PubMed:7623826, ECO:0000269|PubMed:7760831, ECO:0000269|PubMed:7935471, ECO:0000269|PubMed:8455624, ECO:0000269|PubMed:8940068, ECO:0000269|PubMed:8946918, ECO:0000269|PubMed:9121459, ECO:0000269|PubMed:9341107, ECO:0000269|PubMed:9499401, ECO:0000269|PubMed:9535852, ECO:0000269|PubMed:9727490}.; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. {ECO:0000269|PubMed:27189267}. |
| Q07687 | DLX2 | S127 | ochoa | Homeobox protein DLX-2 | Acts as a transcriptional activator (By similarity). Activates transcription of CGA/alpha-GSU, via binding to the downstream activin regulatory element (DARE) in the gene promoter (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis (By similarity). {ECO:0000250|UniProtKB:P40764}. |
| Q08999 | RBL2 | S1112 | ochoa|psp | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q12986 | NFX1 | S95 | ochoa | Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1) | Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:15371341, ECO:0000269|PubMed:17267499}. |
| Q13017 | ARHGAP5 | S765 | ochoa | Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B) | GTPase-activating protein for Rho family members (PubMed:8537347). {ECO:0000269|PubMed:8537347}. |
| Q13136 | PPFIA1 | S150 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13415 | ORC1 | S287 | ochoa | Origin recognition complex subunit 1 (Replication control protein 1) | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
| Q14139 | UBE4A | S1034 | ochoa | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}. |
| Q14517 | FAT1 | S357 | ochoa | Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form] | [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}. |
| Q14641 | INSL4 | S90 | ochoa | Early placenta insulin-like peptide (EPIL) (Insulin-like peptide 4) (Placentin) [Cleaved into: Early placenta insulin-like peptide B chain; Early placenta insulin-like peptide A chain] | May play an important role in trophoblast development and in the regulation of bone formation. |
| Q14686 | NCOA6 | S1481 | ochoa | Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Q14956 | GPNMB | S531 | ochoa | Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type) | Could be a melanogenic enzyme. {ECO:0000250}. |
| Q15648 | MED1 | S238 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15652 | JMJD1C | S284 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q15678 | PTPN14 | S614 | ochoa | Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez) | Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048, ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270, ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:22948661}. |
| Q15772 | SPEG | S390 | ochoa | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Q15911 | ZFHX3 | S2786 | ochoa | Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) | Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329, ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:25105025}. |
| Q16890 | TPD52L1 | S144 | ochoa | Tumor protein D53 (hD53) (Tumor protein D52-like 1) | None |
| Q1MSJ5 | CSPP1 | S401 | ochoa | Centrosome and spindle pole-associated protein 1 | May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}. |
| Q29RF7 | PDS5A | S793 | ochoa | Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) | Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}. |
| Q2KHT3 | CLEC16A | S980 | ochoa | Protein CLEC16A (C-type lectin domain family 16 member A) | Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. {ECO:0000269|PubMed:24949970}. |
| Q2M1K9 | ZNF423 | S1160 | ochoa | Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}. |
| Q3KQU3 | MAP7D1 | S742 | ochoa | MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1) | Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth. Facilitate microtubule stabilization through the maintenance of acetylated stable microtubules. {ECO:0000250|UniProtKB:A2AJI0}. |
| Q4KWH8 | PLCH1 | S1307 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q53GA4 | PHLDA2 | S42 | ochoa | Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C) | Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}. |
| Q5H9R7 | PPP6R3 | S740 | ochoa | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269|PubMed:11401438, ECO:0000269|PubMed:16769727}. |
| Q5JSH3 | WDR44 | S96 | ochoa | WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) | Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| Q5JSZ5 | PRRC2B | S613 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5T0Z8 | C6orf132 | S1160 | ochoa | Uncharacterized protein C6orf132 | None |
| Q5T1V6 | DDX59 | S578 | ochoa | Probable ATP-dependent RNA helicase DDX59 (EC 3.6.4.13) (DEAD box protein 59) (Zinc finger HIT domain-containing protein 5) | None |
| Q5VT06 | CEP350 | S1133 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VUA4 | ZNF318 | S2189 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VYS8 | TUT7 | S960 | ochoa | Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828, PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:18172165, PubMed:19703396, PubMed:22898984, PubMed:25480299, PubMed:25979828, PubMed:28671666). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:Q5BLK4, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:28671666, ECO:0000269|PubMed:30122351}. |
| Q5W0Q7 | USPL1 | S200 | ochoa | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}. |
| Q63HK5 | TSHZ3 | S837 | ochoa | Teashirt homolog 3 (Zinc finger protein 537) | Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity). {ECO:0000250|UniProtKB:Q8CGV9, ECO:0000269|PubMed:19343227}. |
| Q68CP9 | ARID2 | S1391 | ochoa | AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. {ECO:0000269|PubMed:16782067, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q6AI39 | BICRAL | S980 | ochoa | BRD4-interacting chromatin-remodeling complex-associated protein-like (Glioma tumor suppressor candidate region gene 1 protein-like) | Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. {ECO:0000269|PubMed:29374058}. |
| Q6IE81 | JADE1 | S603 | ochoa | Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}. |
| Q6P0Q8 | MAST2 | S1669 | ochoa | Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1) | Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity). {ECO:0000250}. |
| Q6PGQ7 | BORA | S41 | psp | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6PJQ5 | FOXR2 | S139 | ochoa | Forkhead box protein R2 (Forkhead box protein N6) | None |
| Q6UB98 | ANKRD12 | Y129 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UB98 | ANKRD12 | S1799 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UVJ0 | SASS6 | S510 | ochoa|psp | Spindle assembly abnormal protein 6 homolog (HsSAS-6) (Spindle assembly defective protein 6) | Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:15665853, PubMed:16244668, PubMed:17681131). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (By similarity). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). Overexpression results in excess foci-bearing centriolar markers (PubMed:15665853). {ECO:0000250|UniProtKB:Q7ZVT3, ECO:0000250|UniProtKB:Q80UK7, ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:22020124}. |
| Q6UXM1 | LRIG3 | S1001 | ochoa | Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) | May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}. |
| Q6ZN17 | LIN28B | S105 | ochoa | Protein lin-28 homolog B (Lin-28B) | Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. {ECO:0000250|UniProtKB:Q45KJ6, ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:22118463}. |
| Q6ZNE5 | ATG14 | S232 | ochoa | Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) | Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604, PubMed:37632749). Modulates the hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3, ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:23878393, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:37632749}. |
| Q6ZVF9 | GPRIN3 | S336 | ochoa | G protein-regulated inducer of neurite outgrowth 3 (GRIN3) | May be involved in neurite outgrowth. {ECO:0000250}. |
| Q6ZWK4 | RHEX | S128 | ochoa | Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein) | Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation (PubMed:25092874). {ECO:0000269|PubMed:25092874}. |
| Q7RTP6 | MICAL3 | S1649 | ochoa | [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000269|PubMed:21596566, ECO:0000269|PubMed:24440334}. |
| Q7Z333 | SETX | S1621 | ochoa | Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin) | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
| Q7Z3E2 | CCDC186 | S139 | ochoa | Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2) | None |
| Q7Z3U7 | MON2 | S1177 | ochoa | Protein MON2 homolog (Protein SF21) | Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
| Q7Z569 | BRAP | S52 | ochoa | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63) | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}. |
| Q86T90 | KIAA1328 | S521 | ochoa | Protein hinderin | Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes. {ECO:0000269|PubMed:15656913}. |
| Q86VP1 | TAX1BP1 | S508 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86WP2 | GPBP1 | S276 | ochoa | Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein) | Functions as a GC-rich promoter-specific transactivating transcription factor. {ECO:0000250|UniProtKB:Q6NXH3}. |
| Q86WV6 | STING1 | S358 | psp | Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23747010, PubMed:23910378, PubMed:27801882, PubMed:29973723, PubMed:30842659, PubMed:35045565, PubMed:35388221, PubMed:36808561, PubMed:37832545, PubMed:25704810, PubMed:39255680). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:26300263). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, cyclic UMP-AMP (2',3'-cUAMP), and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:21947006, PubMed:23258412, PubMed:23707065, PubMed:23722158, PubMed:23747010, PubMed:23910378, PubMed:26229117, PubMed:30842659, PubMed:35388221, PubMed:37379839). Upon binding to c-di-GMP, cUAMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed:22394562, PubMed:25636800, PubMed:29973723, PubMed:30842653, PubMed:35045565, PubMed:35388221). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:23747010, PubMed:23910378, PubMed:26300263). The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation (PubMed:26150511). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30568238, PubMed:30842662). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed:30842662). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (PubMed:30842662). Promotes autophagy by acting as a proton channel that directs proton efflux from the Golgi to facilitate MAP1LC3B/LC3B lipidation (PubMed:37535724). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (PubMed:30568238, PubMed:30842662). Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy (By similarity). May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons (PubMed:18724357). May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) (By similarity). {ECO:0000250|UniProtKB:Q3TBT3, ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:19433799, ECO:0000269|PubMed:19776740, ECO:0000269|PubMed:21947006, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:23258412, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722158, ECO:0000269|PubMed:23747010, ECO:0000269|PubMed:23910378, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:25704810, ECO:0000269|PubMed:26150511, ECO:0000269|PubMed:26229117, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:27801882, ECO:0000269|PubMed:29973723, ECO:0000269|PubMed:30568238, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:30842659, ECO:0000269|PubMed:30842662, ECO:0000269|PubMed:35045565, ECO:0000269|PubMed:35388221, ECO:0000269|PubMed:36808561, ECO:0000269|PubMed:37379839, ECO:0000269|PubMed:37535724, ECO:0000269|PubMed:37832545, ECO:0000269|PubMed:39255680}.; FUNCTION: (Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed:26405230). Such oncoproteins prevent the ability to sense cytosolic DNA (PubMed:26405230). {ECO:0000269|PubMed:26405230}. |
| Q86WW8 | COA5 | S37 | ochoa | Cytochrome c oxidase assembly factor 5 | Involved in an early step of the mitochondrial complex IV assembly process. {ECO:0000269|PubMed:21457908}. |
| Q86YH2 | ZNF280B | S114 | ochoa | Zinc finger protein 280B (5'OY11.1) (Suppressor of hairy wing homolog 2) (Zinc finger protein 279) (Zinc finger protein 632) | May function as a transcription factor. |
| Q86YW9 | MED12L | S637 | ochoa | Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like) | May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}. |
| Q8IX21 | SLF2 | S68 | ochoa | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication (PubMed:36373674). {ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:36373674}. |
| Q8IZ07 | ANKRD13A | S229 | ochoa | Ankyrin repeat domain-containing protein 13A (Protein KE03) | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}. |
| Q8IZD4 | DCP1B | S448 | ochoa | mRNA-decapping enzyme 1B (EC 3.6.1.62) | May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity). {ECO:0000250|UniProtKB:Q9NPI6}. |
| Q8N5H7 | SH2D3C | S196 | ochoa | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}. |
| Q8N9M5 | TMEM102 | S246 | ochoa | Transmembrane protein 102 (Common beta-chain associated protein) (CBAP) | Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway. {ECO:0000269|PubMed:17828305}. |
| Q8NB90 | AFG2A | S274 | ochoa | ATPase family gene 2 protein homolog A (EC 3.6.4.10) (AFG2 AAA ATPase homolog A) (Ribosome biogenesis protein SPATA5) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5) | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024, PubMed:38554706). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q3UMC0, ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}. |
| Q8NCE2 | MTMR14 | S453 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8NDX5 | PHC3 | S263 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEV8 | EXPH5 | S604 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8TCN5 | ZNF507 | S388 | ochoa | Zinc finger protein 507 | May be involved in transcriptional regulation. |
| Q8TES7 | FBF1 | S334 | ochoa|psp | Fas-binding factor 1 (FBF-1) (Protein albatross) | Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis. {ECO:0000269|PubMed:18838552, ECO:0000269|PubMed:23348840}. |
| Q8TEW8 | PARD3B | S635 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TF44 | C2CD4C | S156 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WUY3 | PRUNE2 | S2416 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WX93 | PALLD | S979 | ochoa | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:15147863, ECO:0000269|PubMed:17537434}. |
| Q8WXE9 | STON2 | S269 | ochoa | Stonin-2 (Stoned B) | Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. {ECO:0000269|PubMed:11381094, ECO:0000269|PubMed:11454741, ECO:0000269|PubMed:21102408}. |
| Q8WYB5 | KAT6B | S371 | ochoa | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:16387653}. |
| Q8WYP5 | AHCTF1 | S2154 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92545 | TMEM131 | S1363 | ochoa | Transmembrane protein 131 (Protein RW1) | Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:32095531}. |
| Q92547 | TOPBP1 | S805 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92576 | PHF3 | S1722 | ochoa | PHD finger protein 3 | None |
| Q92777 | SYN2 | S341 | ochoa | Synapsin-2 (Synapsin II) | Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). {ECO:0000250}. |
| Q92786 | PROX1 | S539 | ochoa | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}. |
| Q969R2 | OSBP2 | S766 | ochoa|psp | Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4) | Binds 7-ketocholesterol (PubMed:11278871). Acts during spermatid development where its function is required prior to the removal of cytoplasm from the sperm head (By similarity). {ECO:0000250|UniProtKB:Q8CF21, ECO:0000269|PubMed:11278871}. |
| Q96AY4 | TTC28 | S2271 | ochoa | Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) | During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000269|PubMed:23036704}. |
| Q96F05 | C11orf24 | S61 | ochoa | Uncharacterized protein C11orf24 (Protein DM4E3) | None |
| Q96F81 | DISP1 | S1161 | ochoa | Protein dispatched homolog 1 | Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}. |
| Q96IZ5 | RBM41 | S232 | ochoa | RNA-binding protein 41 (RNA-binding motif protein 41) | May bind RNA. {ECO:0000305}. |
| Q96NW7 | LRRC7 | S869 | ochoa | Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) | Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. {ECO:0000269|PubMed:11729199}. |
| Q96R06 | SPAG5 | S135 | ochoa|psp | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RL1 | UIMC1 | S653 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q9BRD0 | BUD13 | S325 | ochoa | BUD13 homolog | Involved in pre-mRNA splicing as component of the activated spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000305|PubMed:33509932}. |
| Q9BUF5 | TUBB6 | S239 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BW04 | SARG | S502 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BXA9 | SALL3 | S919 | ochoa | Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3) | Probable transcription factor. |
| Q9BY89 | KIAA1671 | S384 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9BYV9 | BACH2 | S719 | ochoa | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. |
| Q9BYX4 | IFIH1 | S104 | ochoa|psp | Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:28594402, PubMed:32169843, PubMed:33727702). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. {ECO:0000269|PubMed:14645903, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19656871, ECO:0000269|PubMed:21217758, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:22160685, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:28606988, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:33514628, ECO:0000269|PubMed:33727702}. |
| Q9C0D5 | TANC1 | S444 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9C0D7 | ZC3H12C | S123 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9C0D7 | ZC3H12C | S232 | ochoa | Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) | May function as RNase and regulate the levels of target RNA species. {ECO:0000305}. |
| Q9H0K1 | SIK2 | S576 | ochoa|psp | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). {ECO:0000250|UniProtKB:Q8CFH6, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:21084751, ECO:0000269|PubMed:23322770, ECO:0000269|PubMed:26983400}. |
| Q9H2X9 | SLC12A5 | S1045 | ochoa | Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) | Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). {ECO:0000250|UniProtKB:Q63633, ECO:0000269|PubMed:12106695, ECO:0000269|PubMed:24668262}. |
| Q9H2Y7 | ZNF106 | S482 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H2Y7 | ZNF106 | S661 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H4M9 | EHD1 | S349 | ochoa | EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:31615969}. |
| Q9H5I5 | PIEZO2 | S1857 | ochoa | Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B) | Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons being required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, PIEZO2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). Required for Merkel-cell mechanotransduction (By similarity). Plays a major role in light-touch mechanosensation (By similarity). {ECO:0000250|UniProtKB:Q8CD54, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348}. |
| Q9H714 | RUBCNL | S29 | ochoa | Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like) | Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable). {ECO:0000250|UniProtKB:Q3TD16, ECO:0000269|PubMed:28306502, ECO:0000269|PubMed:30704899, ECO:0000305|PubMed:23522960}. |
| Q9H8K7 | PAAT | S177 | ochoa | ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) | ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}. |
| Q9HCJ3 | RAVER2 | S598 | ochoa | Ribonucleoprotein PTB-binding 2 (Protein raver-2) | May bind single-stranded nucleic acids. {ECO:0000305}. |
| Q9HCM1 | RESF1 | S715 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
| Q9NP61 | ARFGAP3 | S331 | ochoa | ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3) | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Q9NQL9 | DMRT3 | S180 | ochoa | Doublesex- and mab-3-related transcription factor 3 | Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity). {ECO:0000250}. |
| Q9NQW6 | ANLN | S295 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NQW6 | ANLN | S927 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NR48 | ASH1L | S1630 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NRA8 | EIF4ENIF1 | S513 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NY74 | ETAA1 | S433 | ochoa | Ewing's tumor-associated antigen 1 (Ewing's tumor-associated antigen 16) | Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720). {ECO:0000269|PubMed:27601467, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:30139873}. |
| Q9NYI0 | PSD3 | S380 | ochoa | PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3) | Guanine nucleotide exchange factor for ARF6. {ECO:0000250}. |
| Q9NZJ5 | EIF2AK3 | S856 | ochoa|psp | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (PubMed:10026192, PubMed:10677345, PubMed:11907036, PubMed:12086964, PubMed:25925385, PubMed:31023583). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:10677345, PubMed:27917829, PubMed:31023583). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:10026192, PubMed:10677345, PubMed:31023583, PubMed:33384352). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (PubMed:31023583). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (PubMed:39116259). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250|UniProtKB:Q9Z2B5, ECO:0000269|PubMed:10026192, ECO:0000269|PubMed:10677345, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:12086964, ECO:0000269|PubMed:25925385, ECO:0000269|PubMed:27917829, ECO:0000269|PubMed:31023583, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:39116259}. |
| Q9NZN3 | EHD3 | S349 | ochoa | EH domain-containing protein 3 (PAST homolog 3) | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250). {ECO:0000250|UniProtKB:Q9QXY6, ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19139087, ECO:0000269|PubMed:21791287, ECO:0000269|PubMed:23781025, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000305|PubMed:20489164}. |
| Q9P0V3 | SH3BP4 | S271 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P0V3 | SH3BP4 | S877 | ochoa | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}. |
| Q9P1Z2 | CALCOCO1 | S77 | ochoa | Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3) | Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}.; FUNCTION: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269|Ref.1}. |
| Q9P242 | NYAP2 | S379 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9UGL1 | KDM5B | S1384 | ochoa | Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B) | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:Q80Y84, ECO:0000269|PubMed:12657635, ECO:0000269|PubMed:16645588, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17363312, ECO:0000269|PubMed:24952722, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:26741168, ECO:0000269|PubMed:27214403, ECO:0000269|PubMed:28262558}. |
| Q9UHQ1 | NARF | S29 | ochoa | Nuclear prelamin A recognition factor (Iron-only hydrogenase-like protein 2) (IOP2) | None |
| Q9UI08 | EVL | S130 | ochoa | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. |
| Q9UJ83 | HACL1 | S192 | ochoa | 2-hydroxyacyl-CoA lyase 1 (EC 4.1.2.63) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) | Peroxisomal 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner (PubMed:10468558, PubMed:21708296, PubMed:28289220). Involved in the degradation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids (PubMed:10468558, PubMed:21708296, PubMed:28289220). Plays a significant role in the biosynthesis of heptadecanal in the liver (By similarity). {ECO:0000250|UniProtKB:Q9QXE0, ECO:0000269|PubMed:10468558, ECO:0000269|PubMed:21708296, ECO:0000269|PubMed:28289220}. |
| Q9UKA4 | AKAP11 | Y1335 | ochoa | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them. |
| Q9UKL3 | CASP8AP2 | S1368 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9UKX7 | NUP50 | S296 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9UKY1 | ZHX1 | S686 | ochoa | Zinc fingers and homeoboxes protein 1 | Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. {ECO:0000269|PubMed:12237128}. |
| Q9ULG1 | INO80 | S1399 | ochoa | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20237820, PubMed:20855601). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820). {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549, ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897, ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}. |
| Q9ULI4 | KIF26A | S1231 | ochoa | Kinesin-like protein KIF26A | Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617). {ECO:0000250|UniProtKB:Q52KG5, ECO:0000269|PubMed:36228617}. |
| Q9ULL1 | PLEKHG1 | S108 | ochoa | Pleckstrin homology domain-containing family G member 1 | None |
| Q9UMD9 | COL17A1 | S374 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UN30 | SCML1 | S238 | ochoa | Sex comb on midleg-like protein 1 | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity). {ECO:0000250}. |
| Q9UPU5 | USP24 | S914 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPW0 | FOXJ3 | S199 | ochoa | Forkhead box protein J3 | Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q8BUR3}. |
| Q9UPW5 | AGTPBP1 | S1168 | ochoa | Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1) | Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). {ECO:0000269|PubMed:22170066, ECO:0000269|PubMed:24022482, ECO:0000269|PubMed:29593216, ECO:0000269|PubMed:30420557}. |
| Q9UQ84 | EXO1 | S376 | ochoa | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Q9Y232 | CDYL | S149 | ochoa | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) | [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:22009739, ECO:0000269|PubMed:28402439, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:29177481}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672). {ECO:0000269|PubMed:19808672}.; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. {ECO:0000269|PubMed:19808672}. |
| Q9Y3M8 | STARD13 | S602 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y3S1 | WNK2 | S1798 | ochoa | Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) | Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:21733846). The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:21733846). Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 (PubMed:21733846). Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression (PubMed:17667937, PubMed:18593598). Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 (PubMed:17667937, PubMed:18593598). WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity (PubMed:17667937, PubMed:18593598). {ECO:0000250|UniProtKB:Q9H4A3, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598, ECO:0000269|PubMed:21733846}. |
| Q9Y3T9 | NOC2L | S240 | ochoa | Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) | Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}. |
| Q9Y4B5 | MTCL1 | S923 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4B5 | MTCL1 | S1772 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y4C1 | KDM3A | S463 | ochoa | Lysine-specific demethylase 3A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) ([histone H3]-dimethyl-L-lysine(9) demethylase 3A) | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}. |
| Q9Y4D2 | DAGLA | S806 | ochoa | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:23502535, PubMed:26668358). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:23502535, PubMed:26668358). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). {ECO:0000250|UniProtKB:Q6WQJ1, ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:26668358}. |
| P20073 | ANXA7 | S393 | Sugiyama | Annexin A7 (Annexin VII) (Annexin-7) (Synexin) | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. |
| Q5S007 | LRRK2 | S2370 | Sugiyama | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q96BY7 | ATG2B | S1395 | Sugiyama | Autophagy-related protein 2 homolog B | Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (PubMed:22219374, PubMed:31721365). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:22219374, PubMed:31721365). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (By similarity). Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31721365). {ECO:0000250|UniProtKB:Q2TAZ0, ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:31721365}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 8.099036e-10 | 9.092 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 3.468296e-04 | 3.460 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 2.421721e-04 | 3.616 |
| R-HSA-1538133 | G0 and Early G1 | 2.776516e-04 | 3.556 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 1.128816e-03 | 2.947 |
| R-HSA-212436 | Generic Transcription Pathway | 1.668188e-03 | 2.778 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 2.335855e-03 | 2.632 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 3.257766e-03 | 2.487 |
| R-HSA-8848021 | Signaling by PTK6 | 4.283272e-03 | 2.368 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 4.283272e-03 | 2.368 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.980172e-03 | 2.400 |
| R-HSA-73857 | RNA Polymerase II Transcription | 4.142942e-03 | 2.383 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 4.977859e-03 | 2.303 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 6.257081e-03 | 2.204 |
| R-HSA-4839726 | Chromatin organization | 7.081488e-03 | 2.150 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 8.513158e-03 | 2.070 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 8.007111e-03 | 2.097 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.629916e-03 | 2.064 |
| R-HSA-8849473 | PTK6 Expression | 9.790684e-03 | 2.009 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.118916e-02 | 1.951 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.118916e-02 | 1.951 |
| R-HSA-1640170 | Cell Cycle | 1.212491e-02 | 1.916 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 1.217685e-02 | 1.914 |
| R-HSA-74160 | Gene expression (Transcription) | 1.042114e-02 | 1.982 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.388015e-02 | 1.858 |
| R-HSA-3247509 | Chromatin modifying enzymes | 1.379345e-02 | 1.860 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 8.453485e-02 | 1.073 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 1.111007e-01 | 0.954 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 1.111007e-01 | 0.954 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 1.111007e-01 | 0.954 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.646111e-02 | 1.577 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.646111e-02 | 1.577 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 1.240943e-01 | 0.906 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 1.368987e-01 | 0.864 |
| R-HSA-2470946 | Cohesin Loading onto Chromatin | 1.368987e-01 | 0.864 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 1.495168e-01 | 0.825 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 1.543217e-02 | 1.812 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 4.934932e-02 | 1.307 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.619512e-01 | 0.791 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 5.304419e-02 | 1.275 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 5.304419e-02 | 1.275 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 5.304419e-02 | 1.275 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 5.304419e-02 | 1.275 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 1.742045e-01 | 0.759 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 1.862794e-01 | 0.730 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 1.862794e-01 | 0.730 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 1.862794e-01 | 0.730 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 1.862794e-01 | 0.730 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 1.981785e-01 | 0.703 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 1.981785e-01 | 0.703 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 7.708772e-02 | 1.113 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 2.099042e-01 | 0.678 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 2.099042e-01 | 0.678 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 2.099042e-01 | 0.678 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 2.099042e-01 | 0.678 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 2.099042e-01 | 0.678 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 2.099042e-01 | 0.678 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 9.466131e-02 | 1.024 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.328460e-01 | 0.633 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 2.440669e-01 | 0.612 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 2.440669e-01 | 0.612 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 2.440669e-01 | 0.612 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 3.080418e-01 | 0.511 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 3.281451e-01 | 0.484 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 3.281451e-01 | 0.484 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.945003e-01 | 0.711 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 3.476667e-01 | 0.459 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 3.572146e-01 | 0.447 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 3.850315e-01 | 0.415 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 4.116494e-01 | 0.385 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 4.028359e-01 | 0.395 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 4.028359e-01 | 0.395 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.181075e-01 | 0.379 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.758950e-01 | 0.425 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 3.181672e-01 | 0.497 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 3.181672e-01 | 0.497 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 2.767584e-01 | 0.558 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 2.767584e-01 | 0.558 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 4.361427e-02 | 1.360 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 3.397602e-01 | 0.469 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 3.397602e-01 | 0.469 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 2.873396e-01 | 0.542 |
| R-HSA-182971 | EGFR downregulation | 1.038386e-01 | 0.984 |
| R-HSA-177929 | Signaling by EGFR | 2.428500e-01 | 0.615 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 3.397602e-01 | 0.469 |
| R-HSA-446107 | Type I hemidesmosome assembly | 1.495168e-01 | 0.825 |
| R-HSA-180292 | GAB1 signalosome | 2.873396e-01 | 0.542 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 3.080418e-01 | 0.511 |
| R-HSA-68962 | Activation of the pre-replicative complex | 4.116494e-01 | 0.385 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 3.572146e-01 | 0.447 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 4.029068e-01 | 0.395 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 8.453485e-02 | 1.073 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 1.111007e-01 | 0.954 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 3.887150e-02 | 1.410 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 2.591127e-01 | 0.587 |
| R-HSA-5693606 | DNA Double Strand Break Response | 3.024617e-01 | 0.519 |
| R-HSA-5693538 | Homology Directed Repair | 4.691506e-02 | 1.329 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.310274e-02 | 1.480 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 3.118473e-02 | 1.506 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.550669e-01 | 0.809 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.097844e-01 | 0.678 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 1.099978e-01 | 0.959 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.168607e-01 | 0.932 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 8.453485e-02 | 1.073 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.938449e-02 | 1.532 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 2.046366e-02 | 1.689 |
| R-HSA-5693548 | Sensing of DNA Double Strand Breaks | 1.981785e-01 | 0.703 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 2.099042e-01 | 0.678 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 1.682257e-01 | 0.774 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 3.080418e-01 | 0.511 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 4.116494e-01 | 0.385 |
| R-HSA-9843745 | Adipogenesis | 1.727734e-01 | 0.763 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.925505e-01 | 0.406 |
| R-HSA-9609690 | HCMV Early Events | 3.897723e-01 | 0.409 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 2.440669e-01 | 0.612 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 3.146326e-02 | 1.502 |
| R-HSA-9031628 | NGF-stimulated transcription | 1.998186e-01 | 0.699 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.038386e-01 | 0.984 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 1.180305e-01 | 0.928 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.397528e-01 | 0.855 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 3.243011e-02 | 1.489 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.184590e-02 | 1.661 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 2.660208e-01 | 0.575 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 1.132466e-01 | 0.946 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 4.116494e-01 | 0.385 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.469344e-02 | 1.460 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.266350e-01 | 0.645 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.486233e-01 | 0.604 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 1.661562e-02 | 1.779 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 2.327800e-02 | 1.633 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.660208e-01 | 0.575 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 9.993304e-02 | 1.000 |
| R-HSA-68877 | Mitotic Prometaphase | 3.798441e-01 | 0.420 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 7.095695e-02 | 1.149 |
| R-HSA-187024 | NGF-independant TRKA activation | 1.111007e-01 | 0.954 |
| R-HSA-68689 | CDC6 association with the ORC:origin complex | 1.111007e-01 | 0.954 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 4.934932e-02 | 1.307 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.742045e-01 | 0.759 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 2.327800e-02 | 1.633 |
| R-HSA-4839744 | Signaling by APC mutants | 1.862794e-01 | 0.730 |
| R-HSA-192814 | vRNA Synthesis | 1.862794e-01 | 0.730 |
| R-HSA-429947 | Deadenylation of mRNA | 7.287421e-02 | 1.137 |
| R-HSA-110362 | POLB-Dependent Long Patch Base Excision Repair | 1.981785e-01 | 0.703 |
| R-HSA-68884 | Mitotic Telophase/Cytokinesis | 1.981785e-01 | 0.703 |
| R-HSA-202670 | ERKs are inactivated | 1.981785e-01 | 0.703 |
| R-HSA-4839735 | Signaling by AXIN mutants | 1.981785e-01 | 0.703 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 1.981785e-01 | 0.703 |
| R-HSA-5689901 | Metalloprotease DUBs | 8.137622e-02 | 1.090 |
| R-HSA-380615 | Serotonin clearance from the synaptic cleft | 2.099042e-01 | 0.678 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 1.228642e-01 | 0.911 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 2.660208e-01 | 0.575 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 2.767584e-01 | 0.558 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.873396e-01 | 0.542 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 3.343006e-02 | 1.476 |
| R-HSA-204005 | COPII-mediated vesicle transport | 1.089998e-01 | 0.963 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.152150e-01 | 0.938 |
| R-HSA-350054 | Notch-HLH transcription pathway | 3.379776e-01 | 0.471 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 3.572146e-01 | 0.447 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.940348e-01 | 0.404 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.029068e-01 | 0.395 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 2.097844e-01 | 0.678 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 4.934932e-02 | 1.307 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 1.326716e-01 | 0.877 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.405170e-01 | 0.619 |
| R-HSA-5689603 | UCH proteinases | 1.280321e-01 | 0.893 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.660208e-01 | 0.575 |
| R-HSA-447043 | Neurofascin interactions | 1.240943e-01 | 0.906 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 2.767584e-01 | 0.558 |
| R-HSA-9620244 | Long-term potentiation | 3.666234e-01 | 0.436 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 2.046366e-02 | 1.689 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 2.950421e-02 | 1.530 |
| R-HSA-8873719 | RAB geranylgeranylation | 8.006007e-02 | 1.097 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 1.476970e-01 | 0.831 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.873396e-01 | 0.542 |
| R-HSA-9707616 | Heme signaling | 8.554664e-02 | 1.068 |
| R-HSA-9646399 | Aggrephagy | 1.527804e-01 | 0.816 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 3.758950e-01 | 0.425 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.640334e-01 | 0.578 |
| R-HSA-5696398 | Nucleotide Excision Repair | 2.483188e-01 | 0.605 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.807970e-01 | 0.552 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 7.473739e-02 | 1.126 |
| R-HSA-9909396 | Circadian clock | 2.328752e-02 | 1.633 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 3.659026e-02 | 1.437 |
| R-HSA-69231 | Cyclin D associated events in G1 | 4.229488e-02 | 1.374 |
| R-HSA-69236 | G1 Phase | 4.229488e-02 | 1.374 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 1.111007e-01 | 0.954 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 4.225923e-02 | 1.374 |
| R-HSA-426048 | Arachidonate production from DAG | 1.742045e-01 | 0.759 |
| R-HSA-1236973 | Cross-presentation of particulate exogenous antigens (phagosomes) | 1.742045e-01 | 0.759 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 1.981785e-01 | 0.703 |
| R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 | 1.981785e-01 | 0.703 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 2.660208e-01 | 0.575 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 2.873396e-01 | 0.542 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 2.977667e-01 | 0.526 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.181672e-01 | 0.497 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.572146e-01 | 0.447 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 3.850315e-01 | 0.415 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 3.940348e-01 | 0.404 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 1.756401e-01 | 0.755 |
| R-HSA-69275 | G2/M Transition | 3.566297e-01 | 0.448 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 3.632663e-01 | 0.440 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 1.029203e-01 | 0.987 |
| R-HSA-73894 | DNA Repair | 1.999642e-01 | 0.699 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.998186e-01 | 0.699 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 7.737659e-02 | 1.111 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 3.572146e-01 | 0.447 |
| R-HSA-69278 | Cell Cycle, Mitotic | 9.558729e-02 | 1.020 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 1.413300e-01 | 0.850 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 2.475994e-02 | 1.606 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 3.281451e-01 | 0.484 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 3.850315e-01 | 0.415 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.116494e-01 | 0.385 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 3.186275e-01 | 0.497 |
| R-HSA-9734767 | Developmental Cell Lineages | 4.036684e-01 | 0.394 |
| R-HSA-112310 | Neurotransmitter release cycle | 1.800379e-01 | 0.745 |
| R-HSA-3214847 | HATs acetylate histones | 8.078307e-02 | 1.093 |
| R-HSA-199991 | Membrane Trafficking | 4.014502e-02 | 1.396 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 3.758950e-01 | 0.425 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 4.130385e-01 | 0.384 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 2.368380e-01 | 0.626 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.614755e-01 | 0.792 |
| R-HSA-447038 | NrCAM interactions | 9.791514e-02 | 1.009 |
| R-HSA-187015 | Activation of TRKA receptors | 1.368987e-01 | 0.864 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 1.368987e-01 | 0.864 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.619512e-01 | 0.791 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 2.099042e-01 | 0.678 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 2.551244e-01 | 0.593 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.396573e-02 | 1.469 |
| R-HSA-5673000 | RAF activation | 1.228642e-01 | 0.911 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 3.281451e-01 | 0.484 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.668710e-02 | 1.331 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.758950e-01 | 0.425 |
| R-HSA-69206 | G1/S Transition | 5.746478e-02 | 1.241 |
| R-HSA-69620 | Cell Cycle Checkpoints | 5.516275e-02 | 1.258 |
| R-HSA-3214842 | HDMs demethylate histones | 7.708772e-02 | 1.113 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 3.291454e-02 | 1.483 |
| R-HSA-5358508 | Mismatch Repair | 2.873396e-01 | 0.542 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.630468e-01 | 0.788 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.648256e-01 | 0.783 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 1.619512e-01 | 0.791 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 2.767584e-01 | 0.558 |
| R-HSA-373760 | L1CAM interactions | 2.997770e-01 | 0.523 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 2.112238e-01 | 0.675 |
| R-HSA-6794361 | Neurexins and neuroligins | 2.212470e-01 | 0.655 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.293566e-01 | 0.482 |
| R-HSA-69481 | G2/M Checkpoints | 6.029839e-02 | 1.220 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.951391e-02 | 1.305 |
| R-HSA-447041 | CHL1 interactions | 1.368987e-01 | 0.864 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 2.099042e-01 | 0.678 |
| R-HSA-9005895 | Pervasive developmental disorders | 2.099042e-01 | 0.678 |
| R-HSA-9697154 | Disorders of Nervous System Development | 2.099042e-01 | 0.678 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.328460e-01 | 0.633 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.440669e-01 | 0.612 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 2.767584e-01 | 0.558 |
| R-HSA-9766229 | Degradation of CDH1 | 2.051540e-01 | 0.688 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.850315e-01 | 0.415 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 2.645382e-01 | 0.578 |
| R-HSA-171319 | Telomere Extension By Telomerase | 3.940348e-01 | 0.404 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 4.361427e-02 | 1.360 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 4.116494e-01 | 0.385 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.085151e-01 | 0.965 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.887150e-02 | 1.410 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 2.767584e-01 | 0.558 |
| R-HSA-5688426 | Deubiquitination | 5.244058e-02 | 1.280 |
| R-HSA-1236394 | Signaling by ERBB4 | 3.396573e-02 | 1.469 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 2.551244e-01 | 0.593 |
| R-HSA-975577 | N-Glycan antennae elongation | 2.551244e-01 | 0.593 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.277454e-01 | 0.894 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.660208e-01 | 0.575 |
| R-HSA-1592230 | Mitochondrial biogenesis | 1.293653e-01 | 0.888 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.225700e-01 | 0.653 |
| R-HSA-112315 | Transmission across Chemical Synapses | 3.925792e-01 | 0.406 |
| R-HSA-166520 | Signaling by NTRKs | 2.297297e-01 | 0.639 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 6.957222e-02 | 1.158 |
| R-HSA-438064 | Post NMDA receptor activation events | 4.130385e-01 | 0.384 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 1.669134e-02 | 1.778 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 1.585649e-01 | 0.800 |
| R-HSA-9675135 | Diseases of DNA repair | 4.638292e-02 | 1.334 |
| R-HSA-1632852 | Macroautophagy | 2.051528e-01 | 0.688 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 1.132466e-01 | 0.946 |
| R-HSA-983189 | Kinesins | 8.006007e-02 | 1.097 |
| R-HSA-198753 | ERK/MAPK targets | 3.181672e-01 | 0.497 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.578977e-01 | 0.802 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 2.699640e-01 | 0.569 |
| R-HSA-3214858 | RMTs methylate histone arginines | 1.786650e-01 | 0.748 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.379776e-01 | 0.471 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.630468e-01 | 0.788 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 1.368987e-01 | 0.864 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 2.440669e-01 | 0.612 |
| R-HSA-389599 | Alpha-oxidation of phytanate | 3.666234e-01 | 0.436 |
| R-HSA-70635 | Urea cycle | 3.758950e-01 | 0.425 |
| R-HSA-9764561 | Regulation of CDH1 Function | 2.482674e-01 | 0.605 |
| R-HSA-420092 | Glucagon-type ligand receptors | 4.029068e-01 | 0.395 |
| R-HSA-112311 | Neurotransmitter clearance | 4.116494e-01 | 0.385 |
| R-HSA-9612973 | Autophagy | 2.549959e-01 | 0.593 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.132466e-01 | 0.946 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 3.887150e-02 | 1.410 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.873396e-01 | 0.542 |
| R-HSA-9663891 | Selective autophagy | 4.181075e-01 | 0.379 |
| R-HSA-75893 | TNF signaling | 2.428500e-01 | 0.615 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 2.536887e-01 | 0.596 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 3.559630e-01 | 0.449 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 5.135469e-02 | 1.289 |
| R-HSA-9926550 | Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh... | 4.575310e-02 | 1.340 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 6.071542e-02 | 1.217 |
| R-HSA-445144 | Signal transduction by L1 | 3.080418e-01 | 0.511 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 3.181672e-01 | 0.497 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 2.753888e-01 | 0.560 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.914648e-01 | 0.407 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.892899e-01 | 0.539 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.293653e-01 | 0.888 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 2.873396e-01 | 0.542 |
| R-HSA-6807004 | Negative regulation of MET activity | 3.080418e-01 | 0.511 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 3.476667e-01 | 0.459 |
| R-HSA-5620971 | Pyroptosis | 3.940348e-01 | 0.404 |
| R-HSA-180024 | DARPP-32 events | 4.029068e-01 | 0.395 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.242978e-01 | 0.906 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 2.135783e-01 | 0.670 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 3.281451e-01 | 0.484 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 1.892008e-01 | 0.723 |
| R-HSA-913531 | Interferon Signaling | 1.445747e-01 | 0.840 |
| R-HSA-8854214 | TBC/RABGAPs | 4.032220e-02 | 1.394 |
| R-HSA-9008059 | Interleukin-37 signaling | 9.921979e-02 | 1.003 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.213211e-02 | 1.142 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.379776e-01 | 0.471 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 2.808117e-01 | 0.552 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 2.212470e-01 | 0.655 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 4.029068e-01 | 0.395 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 3.117620e-01 | 0.506 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 5.683407e-02 | 1.245 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 3.758950e-01 | 0.425 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 3.665031e-01 | 0.436 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 1.228642e-01 | 0.911 |
| R-HSA-9833482 | PKR-mediated signaling | 3.717485e-01 | 0.430 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.212100e-01 | 0.655 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 1.515938e-01 | 0.819 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 3.940348e-01 | 0.404 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.753482e-02 | 1.560 |
| R-HSA-9711123 | Cellular response to chemical stress | 4.181072e-01 | 0.379 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 4.202646e-01 | 0.376 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 4.202646e-01 | 0.376 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 4.202646e-01 | 0.376 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.202646e-01 | 0.376 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.281788e-01 | 0.368 |
| R-HSA-73884 | Base Excision Repair | 4.281788e-01 | 0.368 |
| R-HSA-4791275 | Signaling by WNT in cancer | 4.287541e-01 | 0.368 |
| R-HSA-112316 | Neuronal System | 4.310536e-01 | 0.365 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.331802e-01 | 0.363 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 4.371199e-01 | 0.359 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 4.371199e-01 | 0.359 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 4.371199e-01 | 0.359 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.371199e-01 | 0.359 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 4.371199e-01 | 0.359 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 4.371199e-01 | 0.359 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 4.371199e-01 | 0.359 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 4.371199e-01 | 0.359 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 4.371199e-01 | 0.359 |
| R-HSA-69242 | S Phase | 4.421174e-01 | 0.354 |
| R-HSA-391251 | Protein folding | 4.431124e-01 | 0.353 |
| R-HSA-390522 | Striated Muscle Contraction | 4.453636e-01 | 0.351 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 4.453636e-01 | 0.351 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.453636e-01 | 0.351 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 4.453636e-01 | 0.351 |
| R-HSA-114508 | Effects of PIP2 hydrolysis | 4.453636e-01 | 0.351 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 4.497735e-01 | 0.347 |
| R-HSA-5696400 | Dual Incision in GG-NER | 4.534871e-01 | 0.343 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 4.534871e-01 | 0.343 |
| R-HSA-180746 | Nuclear import of Rev protein | 4.534871e-01 | 0.343 |
| R-HSA-190861 | Gap junction assembly | 4.534871e-01 | 0.343 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.534871e-01 | 0.343 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 4.534871e-01 | 0.343 |
| R-HSA-203615 | eNOS activation | 4.534871e-01 | 0.343 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 4.569860e-01 | 0.340 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 4.578290e-01 | 0.339 |
| R-HSA-68882 | Mitotic Anaphase | 4.583705e-01 | 0.339 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 4.614922e-01 | 0.336 |
| R-HSA-381042 | PERK regulates gene expression | 4.614922e-01 | 0.336 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.614922e-01 | 0.336 |
| R-HSA-2559585 | Oncogene Induced Senescence | 4.614922e-01 | 0.336 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.615803e-01 | 0.336 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 4.649565e-01 | 0.333 |
| R-HSA-1989781 | PPARA activates gene expression | 4.687239e-01 | 0.329 |
| R-HSA-3371511 | HSF1 activation | 4.693804e-01 | 0.328 |
| R-HSA-8941326 | RUNX2 regulates bone development | 4.693804e-01 | 0.328 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.762233e-01 | 0.322 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.771536e-01 | 0.321 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 4.771536e-01 | 0.321 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 4.771536e-01 | 0.321 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.771536e-01 | 0.321 |
| R-HSA-8948216 | Collagen chain trimerization | 4.771536e-01 | 0.321 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.777565e-01 | 0.321 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 4.848134e-01 | 0.314 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 4.848134e-01 | 0.314 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 4.848134e-01 | 0.314 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 4.865756e-01 | 0.313 |
| R-HSA-5610787 | Hedgehog 'off' state | 4.865756e-01 | 0.313 |
| R-HSA-70171 | Glycolysis | 4.865756e-01 | 0.313 |
| R-HSA-9006936 | Signaling by TGFB family members | 4.873804e-01 | 0.312 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 4.923614e-01 | 0.308 |
| R-HSA-69541 | Stabilization of p53 | 4.923614e-01 | 0.308 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.923614e-01 | 0.308 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 4.923614e-01 | 0.308 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 4.923614e-01 | 0.308 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 4.956842e-01 | 0.305 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 4.959462e-01 | 0.305 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 4.959462e-01 | 0.305 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 4.959462e-01 | 0.305 |
| R-HSA-1483255 | PI Metabolism | 4.959462e-01 | 0.305 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 4.964253e-01 | 0.304 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 4.997993e-01 | 0.301 |
| R-HSA-3371568 | Attenuation phase | 4.997993e-01 | 0.301 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 4.997993e-01 | 0.301 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 4.997993e-01 | 0.301 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 4.997993e-01 | 0.301 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 4.997993e-01 | 0.301 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 4.997993e-01 | 0.301 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 4.997993e-01 | 0.301 |
| R-HSA-202433 | Generation of second messenger molecules | 4.997993e-01 | 0.301 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 5.071287e-01 | 0.295 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 5.071287e-01 | 0.295 |
| R-HSA-9694548 | Maturation of spike protein | 5.071287e-01 | 0.295 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 5.071287e-01 | 0.295 |
| R-HSA-597592 | Post-translational protein modification | 5.079078e-01 | 0.294 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 5.097973e-01 | 0.293 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 5.097973e-01 | 0.293 |
| R-HSA-9833110 | RSV-host interactions | 5.097973e-01 | 0.293 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 5.143511e-01 | 0.289 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 5.143511e-01 | 0.289 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 5.143511e-01 | 0.289 |
| R-HSA-6811438 | Intra-Golgi traffic | 5.143511e-01 | 0.289 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 5.143511e-01 | 0.289 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 5.143511e-01 | 0.289 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 5.188926e-01 | 0.285 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.214682e-01 | 0.283 |
| R-HSA-73928 | Depyrimidination | 5.214682e-01 | 0.283 |
| R-HSA-8939211 | ESR-mediated signaling | 5.242136e-01 | 0.280 |
| R-HSA-5654743 | Signaling by FGFR4 | 5.284813e-01 | 0.277 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 5.284813e-01 | 0.277 |
| R-HSA-190828 | Gap junction trafficking | 5.353922e-01 | 0.271 |
| R-HSA-5689880 | Ub-specific processing proteases | 5.378479e-01 | 0.269 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 5.378479e-01 | 0.269 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 5.378479e-01 | 0.269 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 5.422021e-01 | 0.266 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 5.422021e-01 | 0.266 |
| R-HSA-5654741 | Signaling by FGFR3 | 5.422021e-01 | 0.266 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.454989e-01 | 0.263 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 5.489127e-01 | 0.260 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 5.489127e-01 | 0.260 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 5.489127e-01 | 0.260 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 5.489127e-01 | 0.260 |
| R-HSA-6802949 | Signaling by RAS mutants | 5.489127e-01 | 0.260 |
| R-HSA-437239 | Recycling pathway of L1 | 5.555253e-01 | 0.255 |
| R-HSA-2559583 | Cellular Senescence | 5.620026e-01 | 0.250 |
| R-HSA-5620924 | Intraflagellar transport | 5.620413e-01 | 0.250 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.620413e-01 | 0.250 |
| R-HSA-9609646 | HCMV Infection | 5.630134e-01 | 0.249 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.684622e-01 | 0.245 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.684622e-01 | 0.245 |
| R-HSA-157858 | Gap junction trafficking and regulation | 5.684622e-01 | 0.245 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 5.684622e-01 | 0.245 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 5.698842e-01 | 0.244 |
| R-HSA-70326 | Glucose metabolism | 5.752253e-01 | 0.240 |
| R-HSA-3371571 | HSF1-dependent transactivation | 5.810242e-01 | 0.236 |
| R-HSA-9864848 | Complex IV assembly | 5.810242e-01 | 0.236 |
| R-HSA-912446 | Meiotic recombination | 5.810242e-01 | 0.236 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.871680e-01 | 0.231 |
| R-HSA-72187 | mRNA 3'-end processing | 5.871680e-01 | 0.231 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.871680e-01 | 0.231 |
| R-HSA-68875 | Mitotic Prophase | 5.875262e-01 | 0.231 |
| R-HSA-3371556 | Cellular response to heat stress | 5.915677e-01 | 0.228 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 5.932220e-01 | 0.227 |
| R-HSA-5617833 | Cilium Assembly | 5.951569e-01 | 0.225 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.991877e-01 | 0.222 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 5.995624e-01 | 0.222 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.995624e-01 | 0.222 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 6.050662e-01 | 0.218 |
| R-HSA-3214815 | HDACs deacetylate histones | 6.050662e-01 | 0.218 |
| R-HSA-9012852 | Signaling by NOTCH3 | 6.050662e-01 | 0.218 |
| R-HSA-5654736 | Signaling by FGFR1 | 6.108588e-01 | 0.214 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 6.108588e-01 | 0.214 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 6.142548e-01 | 0.212 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 6.165669e-01 | 0.210 |
| R-HSA-194441 | Metabolism of non-coding RNA | 6.277340e-01 | 0.202 |
| R-HSA-191859 | snRNP Assembly | 6.277340e-01 | 0.202 |
| R-HSA-9033241 | Peroxisomal protein import | 6.277340e-01 | 0.202 |
| R-HSA-180786 | Extension of Telomeres | 6.277340e-01 | 0.202 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 6.277340e-01 | 0.202 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.303648e-01 | 0.200 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 6.331955e-01 | 0.198 |
| R-HSA-1227986 | Signaling by ERBB2 | 6.331955e-01 | 0.198 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.331955e-01 | 0.198 |
| R-HSA-351202 | Metabolism of polyamines | 6.331955e-01 | 0.198 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.331955e-01 | 0.198 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.331955e-01 | 0.198 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.331955e-01 | 0.198 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.331955e-01 | 0.198 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.331955e-01 | 0.198 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 6.342418e-01 | 0.198 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 6.385773e-01 | 0.195 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 6.385773e-01 | 0.195 |
| R-HSA-450294 | MAP kinase activation | 6.385773e-01 | 0.195 |
| R-HSA-1442490 | Collagen degradation | 6.385773e-01 | 0.195 |
| R-HSA-446728 | Cell junction organization | 6.403550e-01 | 0.194 |
| R-HSA-109582 | Hemostasis | 6.417278e-01 | 0.193 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 6.429470e-01 | 0.192 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 6.438804e-01 | 0.191 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.438804e-01 | 0.191 |
| R-HSA-6784531 | tRNA processing in the nucleus | 6.438804e-01 | 0.191 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 6.491060e-01 | 0.188 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 6.491060e-01 | 0.188 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 6.491060e-01 | 0.188 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 6.491060e-01 | 0.188 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 6.643291e-01 | 0.178 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.643291e-01 | 0.178 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.662432e-01 | 0.176 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 6.678508e-01 | 0.175 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 6.681925e-01 | 0.175 |
| R-HSA-6807070 | PTEN Regulation | 6.696728e-01 | 0.174 |
| R-HSA-2262752 | Cellular responses to stress | 6.711707e-01 | 0.173 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 6.741106e-01 | 0.171 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 6.741106e-01 | 0.171 |
| R-HSA-5218859 | Regulated Necrosis | 6.741106e-01 | 0.171 |
| R-HSA-418990 | Adherens junctions interactions | 6.817417e-01 | 0.166 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 6.827450e-01 | 0.166 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.836083e-01 | 0.165 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.836083e-01 | 0.165 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 6.836083e-01 | 0.165 |
| R-HSA-448424 | Interleukin-17 signaling | 6.836083e-01 | 0.165 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 6.851267e-01 | 0.164 |
| R-HSA-5632684 | Hedgehog 'on' state | 6.882532e-01 | 0.162 |
| R-HSA-8978934 | Metabolism of cofactors | 6.882532e-01 | 0.162 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.882532e-01 | 0.162 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 6.928303e-01 | 0.159 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 6.928303e-01 | 0.159 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 6.973404e-01 | 0.157 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 6.973404e-01 | 0.157 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 6.973404e-01 | 0.157 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.973404e-01 | 0.157 |
| R-HSA-1226099 | Signaling by FGFR in disease | 7.017846e-01 | 0.154 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 7.017846e-01 | 0.154 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 7.030657e-01 | 0.153 |
| R-HSA-380287 | Centrosome maturation | 7.061638e-01 | 0.151 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 7.061638e-01 | 0.151 |
| R-HSA-68886 | M Phase | 7.089879e-01 | 0.149 |
| R-HSA-1980143 | Signaling by NOTCH1 | 7.104789e-01 | 0.148 |
| R-HSA-9694635 | Translation of Structural Proteins | 7.147310e-01 | 0.146 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.147489e-01 | 0.146 |
| R-HSA-73887 | Death Receptor Signaling | 7.207509e-01 | 0.142 |
| R-HSA-9659379 | Sensory processing of sound | 7.230494e-01 | 0.141 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.237120e-01 | 0.140 |
| R-HSA-5654738 | Signaling by FGFR2 | 7.271176e-01 | 0.138 |
| R-HSA-6806834 | Signaling by MET | 7.271176e-01 | 0.138 |
| R-HSA-1500931 | Cell-Cell communication | 7.301327e-01 | 0.137 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 7.350763e-01 | 0.134 |
| R-HSA-877300 | Interferon gamma signaling | 7.352933e-01 | 0.134 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.411066e-01 | 0.130 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 7.428038e-01 | 0.129 |
| R-HSA-1500620 | Meiosis | 7.465830e-01 | 0.127 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 7.465830e-01 | 0.127 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 7.539763e-01 | 0.123 |
| R-HSA-421270 | Cell-cell junction organization | 7.626918e-01 | 0.118 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 7.675892e-01 | 0.115 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 7.681246e-01 | 0.115 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 7.782014e-01 | 0.109 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.800066e-01 | 0.108 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.812484e-01 | 0.107 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 7.814625e-01 | 0.107 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 7.846758e-01 | 0.105 |
| R-HSA-1474290 | Collagen formation | 7.846758e-01 | 0.105 |
| R-HSA-168255 | Influenza Infection | 7.895199e-01 | 0.103 |
| R-HSA-5683057 | MAPK family signaling cascades | 7.901488e-01 | 0.102 |
| R-HSA-157579 | Telomere Maintenance | 7.970654e-01 | 0.099 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 7.970654e-01 | 0.099 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.000503e-01 | 0.097 |
| R-HSA-190236 | Signaling by FGFR | 8.000503e-01 | 0.097 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 8.000503e-01 | 0.097 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 8.000503e-01 | 0.097 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 8.000503e-01 | 0.097 |
| R-HSA-9824446 | Viral Infection Pathways | 8.018909e-01 | 0.096 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 8.030103e-01 | 0.095 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 8.087450e-01 | 0.092 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 8.096135e-01 | 0.092 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 8.115587e-01 | 0.091 |
| R-HSA-8953854 | Metabolism of RNA | 8.132808e-01 | 0.090 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 8.170632e-01 | 0.088 |
| R-HSA-111885 | Opioid Signalling | 8.170632e-01 | 0.088 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8.179846e-01 | 0.087 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 8.220458e-01 | 0.085 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 8.224075e-01 | 0.085 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 8.236967e-01 | 0.084 |
| R-HSA-418346 | Platelet homeostasis | 8.250210e-01 | 0.084 |
| R-HSA-69239 | Synthesis of DNA | 8.275963e-01 | 0.082 |
| R-HSA-9700206 | Signaling by ALK in cancer | 8.275963e-01 | 0.082 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 8.275963e-01 | 0.082 |
| R-HSA-211000 | Gene Silencing by RNA | 8.275963e-01 | 0.082 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 8.301338e-01 | 0.081 |
| R-HSA-2672351 | Stimuli-sensing channels | 8.301338e-01 | 0.081 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.301338e-01 | 0.081 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.326341e-01 | 0.080 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.326341e-01 | 0.080 |
| R-HSA-202403 | TCR signaling | 8.350977e-01 | 0.078 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.350977e-01 | 0.078 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 8.350977e-01 | 0.078 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 8.399173e-01 | 0.076 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 8.399173e-01 | 0.076 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 8.422742e-01 | 0.075 |
| R-HSA-72172 | mRNA Splicing | 8.429657e-01 | 0.074 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 8.445965e-01 | 0.073 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 8.468848e-01 | 0.072 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.473240e-01 | 0.072 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 8.491395e-01 | 0.071 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 8.513612e-01 | 0.070 |
| R-HSA-9679506 | SARS-CoV Infections | 8.534756e-01 | 0.069 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.567570e-01 | 0.067 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 8.578326e-01 | 0.067 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 8.599268e-01 | 0.066 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 8.599268e-01 | 0.066 |
| R-HSA-73886 | Chromosome Maintenance | 8.640234e-01 | 0.063 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 8.640234e-01 | 0.063 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 8.660267e-01 | 0.062 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 8.660267e-01 | 0.062 |
| R-HSA-162909 | Host Interactions of HIV factors | 8.699457e-01 | 0.061 |
| R-HSA-194138 | Signaling by VEGF | 8.737505e-01 | 0.059 |
| R-HSA-114608 | Platelet degranulation | 8.774444e-01 | 0.057 |
| R-HSA-1474165 | Reproduction | 8.845125e-01 | 0.053 |
| R-HSA-72312 | rRNA processing | 8.865404e-01 | 0.052 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 8.878928e-01 | 0.052 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 8.895458e-01 | 0.051 |
| R-HSA-163685 | Integration of energy metabolism | 8.959186e-01 | 0.048 |
| R-HSA-157118 | Signaling by NOTCH | 8.967676e-01 | 0.047 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 9.004568e-01 | 0.046 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 9.062026e-01 | 0.043 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.142078e-01 | 0.039 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 9.147048e-01 | 0.039 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.167220e-01 | 0.038 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 9.179515e-01 | 0.037 |
| R-HSA-69306 | DNA Replication | 9.203564e-01 | 0.036 |
| R-HSA-9609507 | Protein localization | 9.203564e-01 | 0.036 |
| R-HSA-416476 | G alpha (q) signalling events | 9.225391e-01 | 0.035 |
| R-HSA-6798695 | Neutrophil degranulation | 9.231147e-01 | 0.035 |
| R-HSA-9610379 | HCMV Late Events | 9.249578e-01 | 0.034 |
| R-HSA-162587 | HIV Life Cycle | 9.249578e-01 | 0.034 |
| R-HSA-9711097 | Cellular response to starvation | 9.260661e-01 | 0.033 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 9.313835e-01 | 0.031 |
| R-HSA-5619102 | SLC transporter disorders | 9.353357e-01 | 0.029 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.377647e-01 | 0.028 |
| R-HSA-72306 | tRNA processing | 9.390748e-01 | 0.027 |
| R-HSA-418555 | G alpha (s) signalling events | 9.399754e-01 | 0.027 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 9.408628e-01 | 0.026 |
| R-HSA-611105 | Respiratory electron transport | 9.459194e-01 | 0.024 |
| R-HSA-1483257 | Phospholipid metabolism | 9.469525e-01 | 0.024 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 9.498025e-01 | 0.022 |
| R-HSA-983712 | Ion channel transport | 9.540975e-01 | 0.020 |
| R-HSA-1280218 | Adaptive Immune System | 9.553364e-01 | 0.020 |
| R-HSA-168898 | Toll-like Receptor Cascades | 9.554462e-01 | 0.020 |
| R-HSA-1266738 | Developmental Biology | 9.584439e-01 | 0.018 |
| R-HSA-389948 | Co-inhibition by PD-1 | 9.610434e-01 | 0.017 |
| R-HSA-449147 | Signaling by Interleukins | 9.627126e-01 | 0.017 |
| R-HSA-376176 | Signaling by ROBO receptors | 9.627489e-01 | 0.016 |
| R-HSA-8957322 | Metabolism of steroids | 9.630251e-01 | 0.016 |
| R-HSA-5357801 | Programmed Cell Death | 9.643800e-01 | 0.016 |
| R-HSA-397014 | Muscle contraction | 9.679146e-01 | 0.014 |
| R-HSA-422475 | Axon guidance | 9.683177e-01 | 0.014 |
| R-HSA-392499 | Metabolism of proteins | 9.728381e-01 | 0.012 |
| R-HSA-162906 | HIV Infection | 9.743562e-01 | 0.011 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 9.751115e-01 | 0.011 |
| R-HSA-9675108 | Nervous system development | 9.785884e-01 | 0.009 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 9.809861e-01 | 0.008 |
| R-HSA-162582 | Signal Transduction | 9.828409e-01 | 0.008 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.842737e-01 | 0.007 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.856387e-01 | 0.006 |
| R-HSA-195721 | Signaling by WNT | 9.911477e-01 | 0.004 |
| R-HSA-5663205 | Infectious disease | 9.917584e-01 | 0.004 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 9.932945e-01 | 0.003 |
| R-HSA-1474244 | Extracellular matrix organization | 9.946092e-01 | 0.002 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.953625e-01 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.967206e-01 | 0.001 |
| R-HSA-388396 | GPCR downstream signalling | 9.975678e-01 | 0.001 |
| R-HSA-168256 | Immune System | 9.976007e-01 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 9.983124e-01 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 9.983124e-01 | 0.001 |
| R-HSA-168249 | Innate Immune System | 9.983753e-01 | 0.001 |
| R-HSA-372790 | Signaling by GPCR | 9.991054e-01 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.992663e-01 | 0.000 |
| R-HSA-500792 | GPCR ligand binding | 9.998940e-01 | 0.000 |
| R-HSA-1643685 | Disease | 9.999148e-01 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 9.999659e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999934e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 1.000000e+00 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000e+00 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK19 |
0.880 | 0.838 | 1 | 0.838 |
CDK17 |
0.879 | 0.875 | 1 | 0.875 |
P38G |
0.879 | 0.893 | 1 | 0.886 |
CDK18 |
0.878 | 0.852 | 1 | 0.848 |
CDK8 |
0.876 | 0.841 | 1 | 0.804 |
JNK2 |
0.876 | 0.897 | 1 | 0.854 |
KIS |
0.872 | 0.755 | 1 | 0.786 |
HIPK2 |
0.870 | 0.786 | 1 | 0.830 |
P38D |
0.870 | 0.868 | 1 | 0.889 |
CDK7 |
0.870 | 0.829 | 1 | 0.807 |
CDK16 |
0.869 | 0.838 | 1 | 0.863 |
ERK1 |
0.868 | 0.844 | 1 | 0.839 |
CDK13 |
0.868 | 0.841 | 1 | 0.828 |
CDK12 |
0.866 | 0.842 | 1 | 0.850 |
DYRK2 |
0.866 | 0.779 | 1 | 0.751 |
P38B |
0.866 | 0.848 | 1 | 0.824 |
CDK3 |
0.865 | 0.752 | 1 | 0.869 |
CDK5 |
0.865 | 0.806 | 1 | 0.779 |
JNK3 |
0.864 | 0.880 | 1 | 0.825 |
CDK1 |
0.863 | 0.818 | 1 | 0.828 |
CDK14 |
0.863 | 0.838 | 1 | 0.811 |
CDK9 |
0.862 | 0.832 | 1 | 0.822 |
P38A |
0.860 | 0.828 | 1 | 0.756 |
DYRK4 |
0.860 | 0.786 | 1 | 0.842 |
ERK2 |
0.858 | 0.848 | 1 | 0.791 |
DYRK1B |
0.857 | 0.765 | 1 | 0.798 |
CDK10 |
0.856 | 0.783 | 1 | 0.826 |
HIPK1 |
0.854 | 0.721 | 1 | 0.730 |
CDK4 |
0.854 | 0.830 | 1 | 0.855 |
NLK |
0.853 | 0.764 | 1 | 0.550 |
HIPK3 |
0.853 | 0.718 | 1 | 0.710 |
DYRK1A |
0.852 | 0.659 | 1 | 0.716 |
CDK6 |
0.851 | 0.800 | 1 | 0.830 |
HIPK4 |
0.850 | 0.496 | 1 | 0.539 |
CDK2 |
0.843 | 0.643 | 1 | 0.709 |
JNK1 |
0.842 | 0.785 | 1 | 0.847 |
ERK5 |
0.840 | 0.423 | 1 | 0.467 |
DYRK3 |
0.840 | 0.590 | 1 | 0.695 |
CLK3 |
0.839 | 0.468 | 1 | 0.508 |
SRPK1 |
0.838 | 0.363 | -3 | 0.796 |
CLK1 |
0.835 | 0.446 | -3 | 0.797 |
ICK |
0.830 | 0.393 | -3 | 0.881 |
SRPK2 |
0.829 | 0.303 | -3 | 0.729 |
CDKL5 |
0.829 | 0.203 | -3 | 0.849 |
MTOR |
0.827 | 0.208 | 1 | 0.348 |
CLK4 |
0.826 | 0.403 | -3 | 0.810 |
MAK |
0.824 | 0.524 | -2 | 0.778 |
CDKL1 |
0.824 | 0.180 | -3 | 0.852 |
MOK |
0.820 | 0.500 | 1 | 0.620 |
SRPK3 |
0.820 | 0.271 | -3 | 0.772 |
CLK2 |
0.819 | 0.417 | -3 | 0.786 |
COT |
0.818 | -0.099 | 2 | 0.878 |
PRP4 |
0.818 | 0.465 | -3 | 0.771 |
TBK1 |
0.817 | -0.138 | 1 | 0.152 |
CDC7 |
0.815 | -0.102 | 1 | 0.171 |
ULK2 |
0.813 | -0.149 | 2 | 0.833 |
NUAK2 |
0.813 | 0.043 | -3 | 0.874 |
PRPK |
0.812 | -0.104 | -1 | 0.875 |
GCN2 |
0.811 | -0.185 | 2 | 0.820 |
ATR |
0.810 | -0.048 | 1 | 0.223 |
WNK1 |
0.810 | -0.050 | -2 | 0.892 |
CAMK1B |
0.810 | -0.007 | -3 | 0.902 |
IKKE |
0.810 | -0.165 | 1 | 0.151 |
PDHK4 |
0.809 | -0.144 | 1 | 0.231 |
PKN3 |
0.809 | -0.029 | -3 | 0.879 |
RAF1 |
0.808 | -0.181 | 1 | 0.166 |
PDHK1 |
0.807 | -0.141 | 1 | 0.211 |
MST4 |
0.807 | -0.031 | 2 | 0.842 |
PRKD1 |
0.807 | -0.012 | -3 | 0.864 |
ULK1 |
0.807 | -0.125 | -3 | 0.876 |
MOS |
0.807 | -0.079 | 1 | 0.210 |
WNK3 |
0.806 | -0.129 | 1 | 0.168 |
NDR2 |
0.806 | -0.031 | -3 | 0.852 |
ERK7 |
0.806 | 0.267 | 2 | 0.530 |
PIM3 |
0.805 | -0.039 | -3 | 0.856 |
DSTYK |
0.805 | -0.147 | 2 | 0.860 |
AMPKA1 |
0.805 | -0.031 | -3 | 0.881 |
BMPR2 |
0.805 | -0.182 | -2 | 0.902 |
NEK6 |
0.805 | -0.087 | -2 | 0.868 |
NIK |
0.805 | -0.044 | -3 | 0.908 |
HUNK |
0.804 | -0.106 | 2 | 0.852 |
NUAK1 |
0.804 | 0.009 | -3 | 0.838 |
NEK7 |
0.804 | -0.150 | -3 | 0.877 |
CAMLCK |
0.804 | 0.007 | -2 | 0.867 |
P90RSK |
0.804 | 0.015 | -3 | 0.824 |
NDR1 |
0.804 | -0.039 | -3 | 0.862 |
TGFBR2 |
0.804 | -0.091 | -2 | 0.792 |
NIM1 |
0.803 | -0.040 | 3 | 0.802 |
RSK3 |
0.803 | 0.002 | -3 | 0.818 |
RIPK3 |
0.803 | -0.125 | 3 | 0.795 |
PKN2 |
0.803 | -0.053 | -3 | 0.873 |
MAPKAPK3 |
0.802 | -0.030 | -3 | 0.825 |
IRE1 |
0.802 | -0.074 | 1 | 0.158 |
MARK4 |
0.802 | -0.050 | 4 | 0.861 |
PKCD |
0.802 | -0.026 | 2 | 0.791 |
RSK2 |
0.801 | 0.008 | -3 | 0.815 |
PRKD2 |
0.801 | 0.003 | -3 | 0.812 |
DAPK2 |
0.801 | -0.021 | -3 | 0.905 |
NEK9 |
0.801 | -0.139 | 2 | 0.871 |
AMPKA2 |
0.801 | -0.016 | -3 | 0.853 |
IKKB |
0.800 | -0.199 | -2 | 0.778 |
BCKDK |
0.800 | -0.127 | -1 | 0.842 |
MELK |
0.799 | -0.033 | -3 | 0.848 |
SKMLCK |
0.799 | -0.051 | -2 | 0.872 |
IRE2 |
0.799 | -0.057 | 2 | 0.801 |
TSSK1 |
0.798 | -0.038 | -3 | 0.893 |
CHAK2 |
0.798 | -0.086 | -1 | 0.869 |
PAK6 |
0.797 | 0.015 | -2 | 0.728 |
CAMK2G |
0.797 | -0.121 | 2 | 0.775 |
P70S6KB |
0.797 | 0.002 | -3 | 0.842 |
LATS2 |
0.797 | -0.046 | -5 | 0.762 |
PIM1 |
0.796 | 0.021 | -3 | 0.814 |
PHKG1 |
0.796 | -0.052 | -3 | 0.851 |
MLK1 |
0.796 | -0.172 | 2 | 0.815 |
MNK2 |
0.796 | -0.028 | -2 | 0.807 |
ATM |
0.795 | -0.070 | 1 | 0.192 |
PAK3 |
0.795 | -0.051 | -2 | 0.807 |
PRKD3 |
0.795 | 0.004 | -3 | 0.798 |
DNAPK |
0.795 | -0.036 | 1 | 0.224 |
MASTL |
0.795 | -0.169 | -2 | 0.848 |
CAMK2D |
0.794 | -0.096 | -3 | 0.887 |
RIPK1 |
0.794 | -0.175 | 1 | 0.155 |
QIK |
0.794 | -0.066 | -3 | 0.875 |
QSK |
0.793 | -0.018 | 4 | 0.849 |
NEK2 |
0.793 | -0.104 | 2 | 0.836 |
MAPKAPK2 |
0.793 | -0.017 | -3 | 0.773 |
MLK2 |
0.793 | -0.148 | 2 | 0.833 |
PKCA |
0.792 | -0.029 | 2 | 0.733 |
PKACG |
0.792 | -0.037 | -2 | 0.732 |
TSSK2 |
0.792 | -0.091 | -5 | 0.821 |
SIK |
0.792 | -0.014 | -3 | 0.802 |
PKCB |
0.791 | -0.034 | 2 | 0.743 |
ANKRD3 |
0.791 | -0.171 | 1 | 0.183 |
PKCZ |
0.791 | -0.045 | 2 | 0.805 |
PKR |
0.791 | -0.080 | 1 | 0.179 |
CAMK4 |
0.791 | -0.098 | -3 | 0.855 |
AURC |
0.790 | 0.005 | -2 | 0.654 |
PAK1 |
0.790 | -0.042 | -2 | 0.807 |
PINK1 |
0.790 | 0.162 | 1 | 0.364 |
SGK3 |
0.790 | 0.007 | -3 | 0.812 |
VRK2 |
0.790 | 0.037 | 1 | 0.265 |
IKKA |
0.790 | -0.131 | -2 | 0.774 |
GRK5 |
0.790 | -0.186 | -3 | 0.850 |
TTBK2 |
0.789 | -0.188 | 2 | 0.758 |
PKCG |
0.789 | -0.048 | 2 | 0.732 |
MPSK1 |
0.789 | 0.038 | 1 | 0.218 |
MSK2 |
0.788 | -0.025 | -3 | 0.791 |
SMG1 |
0.788 | -0.074 | 1 | 0.209 |
BRSK2 |
0.788 | -0.071 | -3 | 0.860 |
PKCH |
0.788 | -0.055 | 2 | 0.742 |
WNK4 |
0.787 | -0.075 | -2 | 0.885 |
LATS1 |
0.787 | -0.018 | -3 | 0.862 |
MNK1 |
0.787 | -0.028 | -2 | 0.816 |
MLK3 |
0.787 | -0.095 | 2 | 0.736 |
AKT2 |
0.786 | 0.042 | -3 | 0.741 |
ALK4 |
0.786 | -0.088 | -2 | 0.824 |
DLK |
0.786 | -0.236 | 1 | 0.178 |
MARK2 |
0.786 | -0.031 | 4 | 0.783 |
IRAK4 |
0.785 | -0.093 | 1 | 0.145 |
PHKG2 |
0.785 | -0.052 | -3 | 0.837 |
PLK1 |
0.785 | -0.139 | -2 | 0.827 |
PIM2 |
0.785 | 0.033 | -3 | 0.801 |
CHAK1 |
0.785 | -0.141 | 2 | 0.790 |
PKG2 |
0.785 | -0.014 | -2 | 0.659 |
PAK2 |
0.784 | -0.063 | -2 | 0.793 |
AURB |
0.784 | -0.011 | -2 | 0.656 |
TGFBR1 |
0.784 | -0.083 | -2 | 0.795 |
MAPKAPK5 |
0.784 | -0.058 | -3 | 0.792 |
YSK4 |
0.784 | -0.176 | 1 | 0.153 |
GRK6 |
0.784 | -0.164 | 1 | 0.159 |
MEK1 |
0.783 | -0.147 | 2 | 0.850 |
MARK3 |
0.783 | -0.033 | 4 | 0.816 |
BRSK1 |
0.783 | -0.055 | -3 | 0.835 |
PLK4 |
0.783 | -0.123 | 2 | 0.690 |
PKCT |
0.783 | -0.041 | 2 | 0.757 |
CHK1 |
0.783 | -0.059 | -3 | 0.861 |
GRK1 |
0.782 | -0.097 | -2 | 0.809 |
CAMK1G |
0.782 | -0.035 | -3 | 0.817 |
HRI |
0.782 | -0.137 | -2 | 0.859 |
BMPR1B |
0.782 | -0.087 | 1 | 0.138 |
SNRK |
0.781 | -0.137 | 2 | 0.714 |
RSK4 |
0.781 | -0.001 | -3 | 0.778 |
DCAMKL1 |
0.781 | -0.032 | -3 | 0.814 |
MEKK1 |
0.781 | -0.136 | 1 | 0.180 |
PAK5 |
0.780 | -0.012 | -2 | 0.673 |
PKCI |
0.780 | -0.019 | 2 | 0.769 |
AKT1 |
0.780 | 0.024 | -3 | 0.755 |
MYLK4 |
0.780 | -0.031 | -2 | 0.779 |
MARK1 |
0.779 | -0.060 | 4 | 0.834 |
ZAK |
0.779 | -0.148 | 1 | 0.163 |
CAMK2B |
0.779 | -0.080 | 2 | 0.733 |
MSK1 |
0.778 | -0.022 | -3 | 0.799 |
GRK4 |
0.778 | -0.197 | -2 | 0.843 |
PERK |
0.778 | -0.153 | -2 | 0.841 |
PKACB |
0.777 | 0.006 | -2 | 0.665 |
BRAF |
0.777 | -0.115 | -4 | 0.833 |
PKN1 |
0.777 | -0.011 | -3 | 0.788 |
SMMLCK |
0.777 | -0.011 | -3 | 0.870 |
MLK4 |
0.777 | -0.146 | 2 | 0.734 |
GRK7 |
0.777 | -0.056 | 1 | 0.188 |
FAM20C |
0.777 | -0.049 | 2 | 0.555 |
PAK4 |
0.776 | -0.004 | -2 | 0.682 |
MEK5 |
0.776 | -0.161 | 2 | 0.843 |
NEK5 |
0.776 | -0.140 | 1 | 0.165 |
DCAMKL2 |
0.776 | -0.046 | -3 | 0.845 |
MST3 |
0.776 | -0.069 | 2 | 0.828 |
ACVR2A |
0.775 | -0.124 | -2 | 0.792 |
P70S6K |
0.775 | -0.014 | -3 | 0.773 |
CAMK2A |
0.775 | -0.059 | 2 | 0.730 |
SSTK |
0.775 | -0.059 | 4 | 0.844 |
MEKK2 |
0.775 | -0.130 | 2 | 0.838 |
AURA |
0.774 | -0.026 | -2 | 0.641 |
PLK3 |
0.774 | -0.140 | 2 | 0.756 |
IRAK1 |
0.773 | -0.154 | -1 | 0.781 |
ACVR2B |
0.773 | -0.134 | -2 | 0.802 |
GSK3A |
0.772 | 0.151 | 4 | 0.363 |
DRAK1 |
0.772 | -0.163 | 1 | 0.134 |
MEKK6 |
0.772 | -0.077 | 1 | 0.183 |
ALK2 |
0.771 | -0.120 | -2 | 0.802 |
TLK2 |
0.771 | -0.179 | 1 | 0.160 |
MEKK3 |
0.771 | -0.187 | 1 | 0.174 |
TAO3 |
0.771 | -0.077 | 1 | 0.198 |
NEK11 |
0.770 | -0.132 | 1 | 0.195 |
TAO2 |
0.770 | -0.064 | 2 | 0.851 |
NEK4 |
0.770 | -0.126 | 1 | 0.157 |
PDK1 |
0.770 | -0.065 | 1 | 0.202 |
TLK1 |
0.769 | -0.164 | -2 | 0.832 |
PKCE |
0.769 | -0.007 | 2 | 0.723 |
LKB1 |
0.769 | -0.063 | -3 | 0.873 |
TTBK1 |
0.768 | -0.159 | 2 | 0.666 |
GRK2 |
0.768 | -0.112 | -2 | 0.723 |
SBK |
0.768 | 0.132 | -3 | 0.632 |
PRKX |
0.767 | 0.014 | -3 | 0.708 |
GAK |
0.767 | -0.048 | 1 | 0.209 |
CAMK1D |
0.767 | -0.024 | -3 | 0.744 |
MAP3K15 |
0.767 | -0.103 | 1 | 0.177 |
PKACA |
0.766 | 0.002 | -2 | 0.609 |
HGK |
0.766 | -0.076 | 3 | 0.879 |
NEK8 |
0.766 | -0.163 | 2 | 0.832 |
NEK3 |
0.766 | -0.068 | 1 | 0.181 |
AKT3 |
0.766 | 0.030 | -3 | 0.679 |
CHK2 |
0.765 | 0.003 | -3 | 0.694 |
PBK |
0.765 | -0.028 | 1 | 0.193 |
BMPR1A |
0.765 | -0.099 | 1 | 0.127 |
SGK1 |
0.765 | 0.048 | -3 | 0.666 |
TNIK |
0.764 | -0.059 | 3 | 0.873 |
MINK |
0.764 | -0.114 | 1 | 0.157 |
NEK1 |
0.764 | -0.122 | 1 | 0.149 |
MRCKB |
0.763 | 0.012 | -3 | 0.789 |
CAMKK1 |
0.763 | -0.186 | -2 | 0.791 |
LRRK2 |
0.763 | -0.033 | 2 | 0.857 |
CAMK1A |
0.762 | -0.004 | -3 | 0.709 |
DAPK3 |
0.762 | -0.028 | -3 | 0.831 |
GSK3B |
0.762 | 0.005 | 4 | 0.353 |
LOK |
0.761 | -0.084 | -2 | 0.795 |
GCK |
0.761 | -0.108 | 1 | 0.179 |
MRCKA |
0.761 | 0.003 | -3 | 0.802 |
CAMKK2 |
0.761 | -0.147 | -2 | 0.785 |
KHS1 |
0.761 | -0.059 | 1 | 0.177 |
EEF2K |
0.760 | -0.089 | 3 | 0.838 |
RIPK2 |
0.760 | -0.174 | 1 | 0.147 |
YSK1 |
0.760 | -0.099 | 2 | 0.831 |
HPK1 |
0.759 | -0.092 | 1 | 0.182 |
ROCK2 |
0.759 | -0.002 | -3 | 0.825 |
HASPIN |
0.759 | 0.006 | -1 | 0.699 |
CK1E |
0.758 | -0.071 | -3 | 0.480 |
VRK1 |
0.758 | -0.151 | 2 | 0.896 |
PASK |
0.758 | -0.093 | -3 | 0.867 |
MST2 |
0.757 | -0.162 | 1 | 0.166 |
KHS2 |
0.757 | -0.040 | 1 | 0.188 |
BIKE |
0.756 | -0.018 | 1 | 0.197 |
BUB1 |
0.756 | -0.029 | -5 | 0.772 |
PKG1 |
0.755 | -0.021 | -2 | 0.574 |
DMPK1 |
0.755 | 0.040 | -3 | 0.797 |
DAPK1 |
0.754 | -0.037 | -3 | 0.817 |
MEK2 |
0.753 | -0.175 | 2 | 0.852 |
AAK1 |
0.752 | 0.013 | 1 | 0.202 |
TAK1 |
0.752 | -0.205 | 1 | 0.156 |
MST1 |
0.751 | -0.161 | 1 | 0.156 |
CK1G1 |
0.751 | -0.106 | -3 | 0.472 |
CK2A2 |
0.751 | -0.090 | 1 | 0.113 |
CK1D |
0.751 | -0.048 | -3 | 0.428 |
ROCK1 |
0.750 | -0.003 | -3 | 0.800 |
STK33 |
0.750 | -0.141 | 2 | 0.631 |
CRIK |
0.749 | 0.022 | -3 | 0.757 |
SLK |
0.749 | -0.101 | -2 | 0.741 |
GRK3 |
0.748 | -0.123 | -2 | 0.674 |
PDHK3_TYR |
0.748 | 0.063 | 4 | 0.882 |
LIMK2_TYR |
0.748 | 0.106 | -3 | 0.916 |
PKMYT1_TYR |
0.747 | 0.114 | 3 | 0.868 |
CK1A2 |
0.746 | -0.071 | -3 | 0.429 |
TAO1 |
0.746 | -0.087 | 1 | 0.172 |
ASK1 |
0.745 | -0.118 | 1 | 0.175 |
MYO3B |
0.745 | -0.077 | 2 | 0.830 |
TESK1_TYR |
0.744 | -0.010 | 3 | 0.889 |
TTK |
0.743 | -0.086 | -2 | 0.833 |
MYO3A |
0.741 | -0.087 | 1 | 0.173 |
OSR1 |
0.740 | -0.114 | 2 | 0.828 |
CK2A1 |
0.739 | -0.107 | 1 | 0.105 |
PLK2 |
0.738 | -0.116 | -3 | 0.797 |
MAP2K4_TYR |
0.738 | -0.065 | -1 | 0.892 |
MAP2K7_TYR |
0.738 | -0.123 | 2 | 0.850 |
LIMK1_TYR |
0.737 | -0.002 | 2 | 0.865 |
PINK1_TYR |
0.737 | -0.131 | 1 | 0.216 |
RET |
0.736 | -0.134 | 1 | 0.194 |
TYK2 |
0.736 | -0.168 | 1 | 0.182 |
PDHK4_TYR |
0.736 | -0.032 | 2 | 0.843 |
MST1R |
0.736 | -0.090 | 3 | 0.854 |
JAK2 |
0.736 | -0.111 | 1 | 0.206 |
ROS1 |
0.735 | -0.110 | 3 | 0.819 |
TNNI3K_TYR |
0.735 | -0.021 | 1 | 0.211 |
MAP2K6_TYR |
0.734 | -0.053 | -1 | 0.895 |
CSF1R |
0.734 | -0.085 | 3 | 0.842 |
JAK1 |
0.733 | -0.068 | 1 | 0.178 |
BMPR2_TYR |
0.733 | -0.042 | -1 | 0.864 |
NEK10_TYR |
0.732 | -0.096 | 1 | 0.172 |
TYRO3 |
0.731 | -0.145 | 3 | 0.840 |
DDR1 |
0.731 | -0.094 | 4 | 0.817 |
TNK1 |
0.731 | -0.051 | 3 | 0.815 |
EPHA6 |
0.730 | -0.106 | -1 | 0.860 |
PDHK1_TYR |
0.729 | -0.125 | -1 | 0.897 |
JAK3 |
0.729 | -0.114 | 1 | 0.185 |
STLK3 |
0.729 | -0.172 | 1 | 0.150 |
FGFR1 |
0.729 | -0.021 | 3 | 0.814 |
EPHB4 |
0.727 | -0.135 | -1 | 0.852 |
FGFR2 |
0.726 | -0.046 | 3 | 0.829 |
TEK |
0.726 | -0.010 | 3 | 0.778 |
ABL2 |
0.725 | -0.125 | -1 | 0.818 |
ALPHAK3 |
0.725 | -0.131 | -1 | 0.774 |
YES1 |
0.725 | -0.106 | -1 | 0.856 |
PDGFRB |
0.724 | -0.170 | 3 | 0.851 |
TNK2 |
0.724 | -0.105 | 3 | 0.812 |
INSRR |
0.723 | -0.130 | 3 | 0.792 |
ABL1 |
0.722 | -0.126 | -1 | 0.811 |
KDR |
0.721 | -0.086 | 3 | 0.811 |
FLT3 |
0.721 | -0.165 | 3 | 0.838 |
FGR |
0.721 | -0.188 | 1 | 0.157 |
DDR2 |
0.721 | -0.012 | 3 | 0.785 |
LCK |
0.720 | -0.110 | -1 | 0.824 |
HCK |
0.720 | -0.152 | -1 | 0.828 |
PDGFRA |
0.720 | -0.182 | 3 | 0.846 |
TXK |
0.720 | -0.122 | 1 | 0.144 |
BLK |
0.719 | -0.087 | -1 | 0.835 |
KIT |
0.719 | -0.140 | 3 | 0.840 |
AXL |
0.718 | -0.153 | 3 | 0.829 |
FER |
0.717 | -0.211 | 1 | 0.168 |
ITK |
0.717 | -0.160 | -1 | 0.805 |
EPHB1 |
0.716 | -0.181 | 1 | 0.154 |
EPHB3 |
0.715 | -0.173 | -1 | 0.841 |
YANK3 |
0.715 | -0.094 | 2 | 0.398 |
ALK |
0.714 | -0.149 | 3 | 0.768 |
WEE1_TYR |
0.714 | -0.092 | -1 | 0.755 |
EPHA4 |
0.713 | -0.127 | 2 | 0.734 |
SRMS |
0.713 | -0.200 | 1 | 0.144 |
MERTK |
0.713 | -0.163 | 3 | 0.815 |
EPHB2 |
0.713 | -0.163 | -1 | 0.825 |
FGFR3 |
0.712 | -0.073 | 3 | 0.807 |
MET |
0.712 | -0.136 | 3 | 0.832 |
INSR |
0.711 | -0.147 | 3 | 0.770 |
NTRK2 |
0.710 | -0.182 | 3 | 0.807 |
TEC |
0.710 | -0.152 | -1 | 0.749 |
EPHA1 |
0.709 | -0.156 | 3 | 0.819 |
LTK |
0.709 | -0.168 | 3 | 0.782 |
BTK |
0.709 | -0.216 | -1 | 0.773 |
FLT4 |
0.709 | -0.143 | 3 | 0.788 |
FRK |
0.708 | -0.159 | -1 | 0.839 |
NTRK1 |
0.707 | -0.210 | -1 | 0.830 |
BMX |
0.707 | -0.147 | -1 | 0.710 |
EPHA7 |
0.707 | -0.148 | 2 | 0.754 |
ERBB2 |
0.706 | -0.179 | 1 | 0.160 |
FYN |
0.705 | -0.122 | -1 | 0.795 |
PTK2B |
0.704 | -0.120 | -1 | 0.793 |
MUSK |
0.704 | -0.128 | 1 | 0.122 |
NTRK3 |
0.703 | -0.166 | -1 | 0.780 |
FLT1 |
0.703 | -0.166 | -1 | 0.825 |
EGFR |
0.702 | -0.127 | 1 | 0.138 |
CK1A |
0.702 | -0.101 | -3 | 0.328 |
PTK6 |
0.702 | -0.228 | -1 | 0.740 |
LYN |
0.702 | -0.160 | 3 | 0.759 |
EPHA3 |
0.700 | -0.172 | 2 | 0.721 |
SRC |
0.698 | -0.143 | -1 | 0.801 |
MATK |
0.697 | -0.130 | -1 | 0.735 |
EPHA5 |
0.695 | -0.171 | 2 | 0.723 |
EPHA8 |
0.695 | -0.151 | -1 | 0.808 |
FGFR4 |
0.693 | -0.133 | -1 | 0.766 |
CSK |
0.693 | -0.176 | 2 | 0.760 |
IGF1R |
0.690 | -0.158 | 3 | 0.705 |
ERBB4 |
0.688 | -0.117 | 1 | 0.137 |
PTK2 |
0.687 | -0.104 | -1 | 0.763 |
EPHA2 |
0.685 | -0.160 | -1 | 0.761 |
SYK |
0.683 | -0.137 | -1 | 0.752 |
CK1G3 |
0.681 | -0.105 | -3 | 0.279 |
YANK2 |
0.680 | -0.115 | 2 | 0.409 |
FES |
0.675 | -0.162 | -1 | 0.690 |
ZAP70 |
0.667 | -0.113 | -1 | 0.673 |
CK1G2 |
0.654 | -0.117 | -3 | 0.381 |