Motif 1059 (n=163)

Position-wise Probabilities
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uniprot genes site source protein function
A5A3E0 POTEF T789 ochoa POTE ankyrin domain family member F (ANKRD26-like family C member 1B) (Chimeric POTE-actin protein) None
H0YHG0 None T378 ochoa DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}.
H3BM21 None T210 ochoa Integrin beta None
L7N2F9 None T79 ochoa V-SNARE coiled-coil homology domain-containing protein None
O15400 STX7 T78 ochoa Syntaxin-7 May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
O75116 ROCK2 T977 ochoa Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.
O94986 CEP152 T1241 ochoa Centrosomal protein of 152 kDa (Cep152) Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}.
P02545 LMNA T157 ochoa Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] [Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:23990565, ECO:0000269|PubMed:24741066, ECO:0000269|PubMed:25127216, ECO:0000269|PubMed:31434876, ECO:0000269|PubMed:31548606, ECO:0000269|PubMed:37788673, ECO:0000269|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269|PubMed:20458013}.
P02730 SLC4A1 T49 psp Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233) Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin (PubMed:1538405, PubMed:20151848, PubMed:35835865). Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine (PubMed:10926824, PubMed:14734552, PubMed:16227998, PubMed:24121512, PubMed:28387307). {ECO:0000269|PubMed:10926824, ECO:0000269|PubMed:14734552, ECO:0000269|PubMed:1538405, ECO:0000269|PubMed:16227998, ECO:0000269|PubMed:20151848, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:28387307, ECO:0000269|PubMed:35835865}.; FUNCTION: (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes (PubMed:14630931). Acts as a receptor for P.falciparum (isolate 3D7) MSP1 and thus, facilitates merozoite invasion of erythrocytes (PubMed:12692305). {ECO:0000269|PubMed:12692305, ECO:0000269|PubMed:14630931}.
P05106 ITGB3 T221 ochoa Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:10640428, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:9111081, ECO:0000269|PubMed:9195946, ECO:0000303|PubMed:16322781, ECO:0000303|PubMed:17635696}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9. {ECO:0000269|PubMed:7519807}.; FUNCTION: (Microbial infection) Acts as a receptor for Hantaan virus. {ECO:0000269|PubMed:9618541}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:15834425}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.
P05198 EIF2S1 T281 ochoa Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:16289705, PubMed:38340717). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) (PubMed:16289705). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (PubMed:16289705). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (PubMed:16289705). EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:19131336, PubMed:33384352, PubMed:38340717). EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (PubMed:38340717). {ECO:0000269|PubMed:16289705, ECO:0000269|PubMed:19131336, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:38340717}.
P07195 LDHB T302 ochoa L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}.
P07900 HSP90AA1 T195 ochoa Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}.
P08238 HSP90AB1 T190 ochoa Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}.
P0CG38 POTEI T789 ochoa POTE ankyrin domain family member I None
P0CG39 POTEJ T752 ochoa POTE ankyrin domain family member J None
P11055 MYH3 T1480 ochoa Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) Muscle contraction.
P11717 IGF2R T2362 ochoa Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18046459, ECO:0000269|PubMed:18817523, ECO:0000269|PubMed:2963003}.
P12882 MYH1 T1023 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12882 MYH1 T1286 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12882 MYH1 T1300 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12882 MYH1 T1483 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12882 MYH1 T1501 ochoa Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}.
P12883 MYH7 T1019 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 T1127 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 T1282 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 T1479 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P12883 MYH7 T1497 ochoa Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.
P13533 MYH6 T1129 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13533 MYH6 T1481 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13533 MYH6 T1499 ochoa Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) Muscle contraction.
P13535 MYH8 T1482 ochoa Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) Muscle contraction.
P13569 CFTR T682 psp Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel) Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:12529365, PubMed:12588899, PubMed:12727866, PubMed:15010471, PubMed:17036051, PubMed:1712898, PubMed:17182731, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:26846474, PubMed:28087700, PubMed:8910473, PubMed:9804160). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (PubMed:11524016, PubMed:15284228, PubMed:26627831, PubMed:8910473). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). In vitro, mediates ATP-dependent glutathione flux (PubMed:12727866). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22121115, PubMed:22178883, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17182731, PubMed:17434346, PubMed:27941075). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731, PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851). {ECO:0000269|PubMed:10792060, ECO:0000269|PubMed:11524016, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:12403779, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:12529365, ECO:0000269|PubMed:12588899, ECO:0000269|PubMed:12727866, ECO:0000269|PubMed:14668433, ECO:0000269|PubMed:15010471, ECO:0000269|PubMed:15284228, ECO:0000269|PubMed:16645176, ECO:0000269|PubMed:17036051, ECO:0000269|PubMed:1712898, ECO:0000269|PubMed:17182731, ECO:0000269|PubMed:19019741, ECO:0000269|PubMed:19398555, ECO:0000269|PubMed:19621064, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:25330774, ECO:0000269|PubMed:26627831, ECO:0000269|PubMed:26823428, ECO:0000269|PubMed:26846474, ECO:0000269|PubMed:27714810, ECO:0000269|PubMed:27941075, ECO:0000269|PubMed:28087700, ECO:0000269|PubMed:29393851, ECO:0000269|PubMed:8910473, ECO:0000269|PubMed:9804160, ECO:0000305|PubMed:19923167}.
P15311 EZR T533 ochoa Ezrin (Cytovillin) (Villin-2) (p81) Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.
P16157 ANK1 T1631 ochoa Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.
P18031 PTPN1 T338 ochoa Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
P20700 LMNB1 T55 ochoa Lamin-B1 Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28716252, PubMed:32910914). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28716252, PubMed:32910914). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28716252, PubMed:32910914). {ECO:0000269|PubMed:28716252, ECO:0000269|PubMed:32910914}.
P30260 CDC27 T200 ochoa Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
P31327 CPS1 T1022 ochoa Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
P35580 MYH10 T1203 ochoa Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}.
P35606 COPB2 T869 ochoa Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}.
P35612 ADD2 T55 psp Beta-adducin (Erythrocyte adducin subunit beta) Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}.
P40222 TXLNA T184 ochoa Alpha-taxilin May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
P41208 CETN2 T118 psp Centrin-2 (Caltractin isoform 1) Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}.
P48681 NES T567 ochoa Nestin Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P55010 EIF5 T227 ochoa Eukaryotic translation initiation factor 5 (eIF-5) Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744). {ECO:0000269|PubMed:11166181, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:24319994}.
P60709 ACTB T89 ochoa Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}.
P62258 YWHAE T229 ochoa 14-3-3 protein epsilon (14-3-3E) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}.
P62736 ACTA2 S91 ochoa Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P63027 VAMP2 T79 ochoa Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}.
P63261 ACTG1 T89 ochoa Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}.
P63267 ACTG2 S90 ochoa Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68032 ACTC1 T91 ochoa Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P68133 ACTA1 T91 ochoa Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P78363 ABCA4 T901 psp Retinal-specific phospholipid-transporting ATPase ABCA4 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM proteinv) (RmP) (Retinal-specific ATP-binding cassette transporter) (Stargardt disease protein) Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where 11-cis-retinylidene-phosphatidylethanolamine is then isomerized to its all-trans isomer and reduced by RDH8 to produce all-trans-retinol. This transport activity ensures that all-trans-retinal generated from photoexcitation and 11-cis-retinal not needed for the regeneration of rhodopsin and cone opsins are effectively cleared from the photoreceptors, therefore preventing their accumulation and the formation of toxic bisretinoid (PubMed:10075733, PubMed:20404325, PubMed:22735453, PubMed:23144455, PubMed:24097981, PubMed:29847635, PubMed:33375396). Displays ATPase activity in vitro in absence of retinal substrate (PubMed:33605212, PubMed:39128720, PubMed:29847635, PubMed:33375396). May display GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (PubMed:22735453). Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes N-retinylidene-phosphatidylethanolamine release (By similarity). {ECO:0000250|UniProtKB:F1MWM0, ECO:0000269|PubMed:10075733, ECO:0000269|PubMed:20404325, ECO:0000269|PubMed:22735453, ECO:0000269|PubMed:23144455, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:29847635, ECO:0000269|PubMed:33375396, ECO:0000269|PubMed:33605212, ECO:0000269|PubMed:39128720}.
P80303 NUCB2 T335 ochoa Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). {ECO:0000250|UniProtKB:P81117, ECO:0000250|UniProtKB:Q9JI85}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (PubMed:39562740). {ECO:0000250|UniProtKB:Q9JI85, ECO:0000269|PubMed:39562740}.
P82979 SARNP T65 ochoa SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}.
Q00341 HDLBP T626 ochoa Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Q01484 ANK2 T3797 ochoa Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.
Q03701 CEBPZ T33 ochoa CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) Stimulates transcription from the HSP70 promoter.
Q08379 GOLGA2 T437 ochoa Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}.
Q08477 CYP4F3 T233 ochoa Cytochrome P450 4F3 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (CYPIVF3) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase CYP4F3) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 2) (Leukotriene-B(4) omega-hydroxylase 2) (EC 1.14.14.94) A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:11461919, PubMed:15145985, PubMed:16547005, PubMed:16820285, PubMed:18065749, PubMed:18182499, PubMed:18577768, PubMed:8486631, PubMed:9675028). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:9675028). May play a role in inactivation of pro-inflammatory and anti-inflammatory oxylipins during the resolution of inflammation (PubMed:11461919, PubMed:15145985, PubMed:15364545, PubMed:16547005, PubMed:16820285, PubMed:18065749, PubMed:18182499, PubMed:18577768, PubMed:8486631, PubMed:9675028). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:16547005, ECO:0000269|PubMed:16820285, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:8486631, ECO:0000269|PubMed:9675028}.; FUNCTION: [Isoform CYP4F3A]: Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of oxylipins in myeloid cells, displaying higher affinity for arachidonate metabolite leukotriene B4 (LTB4) (PubMed:11461919, PubMed:15364545, PubMed:8486631, PubMed:9675028). Inactivates LTB4 via three successive oxidative transformations to 20-hydroxy-LTB4, then to 20-oxo-LTB4 and to 20-carboxy-LTB4 (PubMed:9675028). Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate (PubMed:15145985). Omega-hydroxylates monohydroxy polyunsaturated fatty acids (PUFAs), including hydroxyeicosatetraenoates (HETEs) and hydroxyeicosapentaenoates (HEPEs), to dihydroxy compounds (PubMed:15364545, PubMed:9675028). Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Has low hydroxylase activity toward PUFAs (PubMed:11461919, PubMed:18577768). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:8486631, ECO:0000269|PubMed:9675028}.; FUNCTION: [Isoform CYP4F3B]: Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of polyunsaturated fatty acids (PUFAs) (PubMed:11461919, PubMed:16820285, PubMed:18577768). Participates in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:11461919, PubMed:16820285, PubMed:18577768). Has high omega-hydroxylase activity toward other PUFAs, including eicosatrienoic acid (ETA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (PubMed:16820285, PubMed:18577768). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of PUFAs with lower efficiency (PubMed:18577768). Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid and hexacosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acids, thereby initiating chain shortening (PubMed:16547005, PubMed:18182499). Omega-hydroxylates long-chain 3-hydroxy fatty acids, likely initiating the oxidative conversion to the corresponding 3-hydroxydicarboxylic fatty acids (PubMed:18065749). Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate (PubMed:15145985). {ECO:0000269|PubMed:11461919, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:16547005, ECO:0000269|PubMed:16820285, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18577768}.
Q13464 ROCK1 T455 psp Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:23093407, PubMed:23355470, PubMed:8617235, PubMed:9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}.
Q13823 GNL2 T510 ochoa Nucleolar GTP-binding protein 2 (Autoantigen NGP-1) GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}.
Q14141 SEPTIN6 T323 ochoa Septin-6 Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17229681, ECO:0000269|PubMed:17803907, ECO:0000305|PubMed:25588830}.
Q14151 SAFB2 T193 ochoa Scaffold attachment factor B2 (SAF-B2) Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Q14320 FAM50A T164 ochoa Protein FAM50A (Protein HXC-26) (Protein XAP-5) Probably involved in the regulation of pre-mRNA splicing. {ECO:0000269|PubMed:32703943}.
Q14978 NOLC1 T607 ochoa Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786). {ECO:0000269|PubMed:10567578, ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}.
Q15424 SAFB T194 ochoa Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). {ECO:0000250|UniProtKB:D3YXK2, ECO:0000269|PubMed:12660241, ECO:0000269|PubMed:9671816}.
Q15836 VAMP3 T62 ochoa Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}.
Q16513 PKN2 T951 ochoa Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}.
Q16625 OCLN T438 psp Occludin May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.; FUNCTION: (Microbial infection) Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes. {ECO:0000269|PubMed:19182773, ECO:0000269|PubMed:20375010}.
Q58FF7 HSP90AB3P T169 ochoa Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc) Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q5M775 SPECC1 T424 ochoa Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) None
Q5THJ4 VPS13D T911 ochoa Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}.
Q5VST9 OBSCN T5798 psp Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}.
Q6NUP7 PPP4R4 T156 ochoa Serine/threonine-protein phosphatase 4 regulatory subunit 4 Putative regulatory subunit of serine/threonine-protein phosphatase 4.
Q6S8J3 POTEE T789 ochoa POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2) None
Q7L7X3 TAOK1 T480 ochoa Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}.
Q86Y82 STX12 T93 ochoa Syntaxin-12 SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. {ECO:0000250|UniProtKB:G3V7P1}.
Q8IUG5 MYO18B T1548 ochoa Unconventional myosin-XVIIIb May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Q8IX12 CCAR1 T667 psp Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.
Q8NDB2 BANK1 T668 ochoa B-cell scaffold protein with ankyrin repeats Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269|PubMed:11782428}.
Q8NEZ4 KMT2C T74 ochoa Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}.
Q8NG31 KNL1 T1019 ochoa Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}.
Q8TEQ6 GEMIN5 T1330 ochoa Gem-associated protein 5 (Gemin5) The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887). {ECO:0000269|PubMed:11714716, ECO:0000269|PubMed:16314521, ECO:0000269|PubMed:16857593, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19377484, ECO:0000269|PubMed:19750007, ECO:0000269|PubMed:20513430, ECO:0000269|PubMed:25911097, ECO:0000269|PubMed:27507887, ECO:0000269|PubMed:27834343, ECO:0000269|PubMed:27881600, ECO:0000269|PubMed:27881601, ECO:0000269|PubMed:33963192, ECO:0000269|Ref.27}.
Q8WWQ0 PHIP T1775 ochoa PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:12242307, ECO:0000269|PubMed:21834987}.
Q92932 PTPRN2 T441 ochoa Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475, ECO:0000269|PubMed:26620550}.
Q96PY5 FMNL2 T450 ochoa Formin-like protein 2 (Formin homology 2 domain-containing protein 2) Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269|PubMed:21834987}.
Q99708 RBBP8 T126 psp DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}.
Q9BV73 CEP250 T2233 ochoa Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMed:36282799). Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion (PubMed:36282799). May be involved in ciliogenesis (PubMed:28005958). {ECO:0000269|PubMed:28005958, ECO:0000269|PubMed:30404835, ECO:0000269|PubMed:36282799}.
Q9BYM8 RBCK1 T329 ochoa RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (PubMed:12629548, PubMed:17449468, PubMed:18711448). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (PubMed:12629548). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:17449468, PubMed:18711448). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:17006537, PubMed:21455173, PubMed:21455180, PubMed:21455181). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:17006537, PubMed:19136968, PubMed:21455173, PubMed:21455180, PubMed:21455181). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:20005846, PubMed:21455181). {ECO:0000269|PubMed:12629548, ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:17449468, ECO:0000269|PubMed:18711448, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:28481331}.
Q9BYW2 SETD2 T1897 ochoa Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.
Q9BYX7 POTEKP T89 ochoa Putative beta-actin-like protein 3 (Kappa-actin) (POTE ankyrin domain family member K) None
Q9BZC7 ABCA2 T2412 ochoa ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}.
Q9GZX5 ZNF350 T283 ochoa Zinc finger protein 350 (KRAB zinc finger protein ZFQR) (Zinc finger and BRCA1-interacting protein with a KRAB domain 1) (Zinc finger protein ZBRK1) Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3. {ECO:0000269|PubMed:11090615}.
Q9H0A0 NAT10 T672 ochoa RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP) RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:P53914, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25411247, ECO:0000269|PubMed:25653167, ECO:0000269|PubMed:26882543, ECO:0000269|PubMed:27993683, ECO:0000269|PubMed:30165671, ECO:0000269|PubMed:30449621, ECO:0000269|PubMed:31722219, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:35679869}.
Q9H0X9 OSBPL5 T332 ochoa Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}.
Q9H2M9 RAB3GAP2 T566 ochoa Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:24891604, PubMed:9733780). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000269|PubMed:24891604, ECO:0000269|PubMed:26063829, ECO:0000269|PubMed:9733780}.
Q9H2X9 SLC12A5 T929 psp Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). {ECO:0000250|UniProtKB:Q63633, ECO:0000269|PubMed:12106695, ECO:0000269|PubMed:24668262}.
Q9H2Y7 ZNF106 T397 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H4A6 GOLPH3 T143 psp Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS) Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.
Q9H4G0 EPB41L1 T54 ochoa Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.
Q9H501 ESF1 T630 ochoa ESF1 homolog (ABT1-associated protein) May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity). {ECO:0000250}.
Q9H9H4 VPS37B T68 ochoa Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}.
Q9NP79 VTA1 T150 ochoa Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. {ECO:0000250, ECO:0000269|PubMed:15644320}.
Q9NS00 C1GALT1 T77 ochoa Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1) Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (PubMed:11677243). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity). {ECO:0000250|UniProtKB:Q7K237, ECO:0000250|UniProtKB:Q9JJ06, ECO:0000269|PubMed:11677243}.
Q9NVA2 SEPTIN11 T322 ochoa Septin-11 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}.
Q9NZU5 LMCD1 T227 ochoa LIM and cysteine-rich domains protein 1 (Dyxin) Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. {ECO:0000250, ECO:0000269|PubMed:20026769}.
Q9P0V9 SEPTIN10 T347 ochoa Septin-10 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}.
Q9UHP3 USP25 T680 psp Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response (PubMed:29518389, PubMed:37683630). Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 (PubMed:28619731, PubMed:30926243, PubMed:38875478). Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program (PubMed:37339955). Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 (PubMed:37683630). In turn, restricts virus production by regulating cholesterol biosynthetic flux (PubMed:37683630). Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 (PubMed:23042150). Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance (PubMed:30579117). {ECO:0000269|PubMed:23042150, ECO:0000269|PubMed:28619731, ECO:0000269|PubMed:29518389, ECO:0000269|PubMed:30579117, ECO:0000269|PubMed:30926243, ECO:0000269|PubMed:37339955, ECO:0000269|PubMed:37683630, ECO:0000269|PubMed:38875478}.; FUNCTION: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
Q9UHW9 SLC12A6 T991 ochoa|psp Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) [Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015). May contribute to cell volume homeostasis in single cells (PubMed:16048901, PubMed:27485015). {ECO:0000269|PubMed:10600773, ECO:0000269|PubMed:11551954, ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:18566107, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21628467, ECO:0000269|PubMed:27485015, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901, PubMed:33199848, PubMed:34031912). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000269|PubMed:33199848, ECO:0000269|PubMed:34031912, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.; FUNCTION: [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:16048901). May contribute to cell volume homeostasis in single cells (Probable). {ECO:0000269|PubMed:16048901, ECO:0000305|PubMed:16048901}.
Q9UKN1 MUC12 T5424 ochoa Mucin-12 (MUC-12) (Mucin-11) (MUC-11) Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}.
Q9UKN8 GTF3C4 T655 ochoa General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta) Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin (PubMed:10523658). Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3 (PubMed:10523658). May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F (PubMed:10523658). May be localized close to the A box (PubMed:10523658). {ECO:0000269|PubMed:10523658}.
Q9UKX2 MYH2 T1025 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 T1288 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 T1485 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX2 MYH2 T1503 ochoa Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}.
Q9UKX3 MYH13 T1483 ochoa Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}.
Q9ULD2 MTUS1 T1204 ochoa Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
Q9UP95 SLC12A4 T926 ochoa Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}.
Q9UQC2 GAB2 T294 ochoa GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Q9Y247 FAM50B T150 ochoa Protein FAM50B (Protein XAP-5-like) None
Q9Y4B5 MTCL1 T553 ochoa Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}.
Q9Y623 MYH4 T1483 ochoa Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) Muscle contraction.
Q9Y666 SLC12A7 T926 ochoa|psp Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250, ECO:0000269|PubMed:10913127}.
Q9Y6C2 EMILIN1 T701 ochoa EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) Involved in elastic and collagen fibers formation. It is required for EFEMP2 deposition into the extracellular matrix, and collagen network assembly and cross-linking via protein-lysine 6-oxidase/LOX activity (PubMed:36351433). May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved in the processes that regulate vessel assembly. Has cell adhesive capacity. {ECO:0000269|PubMed:36351433}.
Q58FF6 HSP90AB4P T165 Sugiyama Putative heat shock protein HSP 90-beta 4 Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins. {ECO:0000250}.
Q96A49 SYAP1 T306 Sugiyama Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA) Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339). {ECO:0000269|PubMed:23300339}.
P33176 KIF5B T809 Sugiyama Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.
Q14157 UBAP2L T23 Sugiyama Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}.
Q86VS8 HOOK3 T291 Sugiyama Protein Hook homolog 3 (h-hook3) (hHK3) Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:25035494, PubMed:33734450). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33734450}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}.
Q13619 CUL4A Y259 Sugiyama Cullin-4A (CUL-4A) Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620, PubMed:30166453, PubMed:33854232, PubMed:33854239). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component (PubMed:14578910, PubMed:14739464, PubMed:15448697, PubMed:15548678, PubMed:15811626, PubMed:16678110, PubMed:17041588, PubMed:24209620). DCX(DET1-COP1) directs ubiquitination of JUN (PubMed:14739464). DCX(DDB2) directs ubiquitination of XPC (PubMed:15811626). DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition (PubMed:16678110, PubMed:17041588, PubMed:24209620). DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:14578910, PubMed:15448697, PubMed:15548678). DCX(DTL) directs autoubiquitination of DTL (PubMed:23478445). In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip (PubMed:16537899). Is involved in ubiquitination of HOXA9 (PubMed:14609952). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). The DCX(ERCC8) complex (also named CSA complex) plays a role in transcription-coupled repair (TCR) (PubMed:12732143, PubMed:32355176, PubMed:38316879). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:15811626, ECO:0000269|PubMed:16537899, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:24209620, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:32355176, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}.
O43283 MAP3K13 T421 Sugiyama Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
P13987 CD59 T85 Sugiyama CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59) Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260). {ECO:0000269|PubMed:11882685, ECO:0000269|PubMed:1698710, ECO:0000269|PubMed:2475111, ECO:0000269|PubMed:2475570, ECO:0000269|PubMed:2606909, ECO:0000269|PubMed:36797260, ECO:0000269|PubMed:9053451}.; FUNCTION: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes. {ECO:0000269|PubMed:8670172}.
P49959 MRE11 T524 Sugiyama Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738, PubMed:31353207, PubMed:37696958, PubMed:38128537, PubMed:9590181, PubMed:9651580, PubMed:9705271). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (PubMed:24316220, PubMed:28867292, PubMed:31353207, PubMed:38128537). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (PubMed:24316220, PubMed:27889449, PubMed:28867292, PubMed:36050397, PubMed:38128537). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11741547, PubMed:22078559, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:29670289, PubMed:31353207, PubMed:36563124, PubMed:9590181, PubMed:9651580, PubMed:9705271). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (PubMed:24316220). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (PubMed:24316220, PubMed:28867292). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182). MRE11 endonuclease activity is also enhanced by AGER/RAGE (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (PubMed:14657032, PubMed:15064416, PubMed:15790808, PubMed:16622404). The MRN complex is also required for the processing of R-loops (PubMed:31537797). The MRN complex is involved in the activation of the cGAS-STING pathway induced by DNA damage during tumorigenesis: the MRN complex acts by displacing CGAS from nucleosome sequestration, thereby activating it (By similarity). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). {ECO:0000250|UniProtKB:Q61216, ECO:0000269|PubMed:10888888, ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:14657032, ECO:0000269|PubMed:15064416, ECO:0000269|PubMed:15790808, ECO:0000269|PubMed:16622404, ECO:0000269|PubMed:22078559, ECO:0000269|PubMed:23080121, ECO:0000269|PubMed:24316220, ECO:0000269|PubMed:26240375, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:28867292, ECO:0000269|PubMed:29670289, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:31353207, ECO:0000269|PubMed:31537797, ECO:0000269|PubMed:36050397, ECO:0000269|PubMed:36563124, ECO:0000269|PubMed:37696958, ECO:0000269|PubMed:38128537, ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580, ECO:0000269|PubMed:9705271}.; FUNCTION: MRE11 contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). {ECO:0000305}.
Q13620 CUL4B Y413 Sugiyama Cullin-4B (CUL-4B) Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239). The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460, PubMed:29779948). CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460). Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899). Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110). A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239). The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453). Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544). Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224). Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224). With CUL4A, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:16322693, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:18235224, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:30166453, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854239}.
P00966 ASS1 T208 Sugiyama Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000305|PubMed:18473344, ECO:0000305|PubMed:27287393, ECO:0000305|PubMed:8792870}.
O60841 EIF5B T78 Sugiyama Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon (PubMed:10659855, PubMed:35732735). Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex (PubMed:12569173, PubMed:35732735). Is released after formation of the 80S initiation complex (PubMed:35732735). Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes (PubMed:10659855, PubMed:35732735). In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit (PubMed:10659855). {ECO:0000269|PubMed:10659855, ECO:0000269|PubMed:12569173, ECO:0000269|PubMed:35732735}.
P17980 PSMC3 T166 Sugiyama 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1) Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}.
P27816 MAP4 T57 Sugiyama Microtubule-associated protein 4 (MAP-4) Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
Q15293 RCN1 T211 Sugiyama Reticulocalbin-1 May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Q5JSH3 WDR44 T364 Sugiyama WD repeat-containing protein 44 (Rab11-binding protein) (Rab11BP) (Rabphilin-11) Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). {ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.
P61758 VBP1 T45 Sugiyama Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
Q9UBU7 DBF4 T390 Sugiyama Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.
P00505 GOT2 T192 Sugiyama Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}.
P35579 MYH9 T1221 Sugiyama Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}.
Q7KZF4 SND1 T134 Sugiyama Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator) Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity). {ECO:0000250|UniProtKB:Q78PY7, ECO:0000269|PubMed:12234934, ECO:0000269|PubMed:18453631, ECO:0000269|PubMed:28546213, ECO:0000269|PubMed:9809063}.; FUNCTION: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). {ECO:0000269|PubMed:7651391}.; FUNCTION: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. {ECO:0000269|PubMed:37794589}.
P31947 SFN T228 Sugiyama 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}.
P63104 YWHAZ T226 Sugiyama 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). {ECO:0000250|UniProtKB:O55043, ECO:0000269|PubMed:14578935, ECO:0000269|PubMed:15071501, ECO:0000269|PubMed:15644438, ECO:0000269|PubMed:16376338, ECO:0000269|PubMed:16959763, ECO:0000269|PubMed:31024343, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:9360956}.
Q9UHV9 PFDN2 T103 Sugiyama Prefoldin subunit 2 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
P11413 G6PD T406 SIGNOR Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394, ECO:0000269|PubMed:26479991, ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:38066190, ECO:0000269|PubMed:743300}.
P50395 GDI2 T412 Sugiyama Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}.
A0MZ66 SHTN1 T298 Sugiyama Shootin-1 (Shootin1) Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250|UniProtKB:A0MZ67, ECO:0000250|UniProtKB:Q8K2Q9}.
Q13164 MAPK7 T209 Sugiyama Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.
P51812 RPS6KA3 T157 Sugiyama Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:16213824, PubMed:16223362, PubMed:17360704, PubMed:9770464). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:10436156, PubMed:9770464). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.
Q15349 RPS6KA2 T148 Sugiyama Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
Q15418 RPS6KA1 T151 Sugiyama Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}.
P35606 COPB2 T792 Sugiyama Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. {ECO:0000269|PubMed:34450031}.; FUNCTION: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). {ECO:0000250}.
O75116 ROCK2 T878 Sugiyama Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.
P27797 CALR T181 Sugiyama Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}.
P31946 YWHAB T228 Sugiyama 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}.
Q9P2E9 RRBP1 T1306 Sugiyama Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.
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reactome_id name p -log10_p
R-HSA-199991 Membrane Trafficking 4.721963e-07 6.326
R-HSA-373760 L1CAM interactions 1.244818e-06 5.905
R-HSA-5653656 Vesicle-mediated transport 1.543324e-06 5.812
R-HSA-437239 Recycling pathway of L1 2.046285e-06 5.689
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 2.440623e-06 5.612
R-HSA-9913351 Formation of the dystrophin-glycoprotein complex (DGC) 2.850172e-06 5.545
R-HSA-426117 Cation-coupled Chloride cotransporters 4.186800e-06 5.378
R-HSA-9764561 Regulation of CDH1 Function 6.046446e-06 5.218
R-HSA-422475 Axon guidance 7.118269e-06 5.148
R-HSA-9675108 Nervous system development 1.710213e-05 4.767
R-HSA-1640170 Cell Cycle 2.258904e-05 4.646
R-HSA-3000171 Non-integrin membrane-ECM interactions 2.867940e-05 4.542
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 3.306024e-05 4.481
R-HSA-111447 Activation of BAD and translocation to mitochondria 5.076573e-05 4.294
R-HSA-9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 5.076573e-05 4.294
R-HSA-9735871 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 5.076573e-05 4.294
R-HSA-390522 Striated Muscle Contraction 6.707155e-05 4.173
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 1.239983e-04 3.907
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 1.450370e-04 3.839
R-HSA-198753 ERK/MAPK targets 1.683228e-04 3.774
R-HSA-69481 G2/M Checkpoints 1.283882e-04 3.891
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 1.539488e-04 3.813
R-HSA-199920 CREB phosphorylation 1.220899e-04 3.913
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 1.241750e-04 3.906
R-HSA-69620 Cell Cycle Checkpoints 1.652699e-04 3.782
R-HSA-373755 Semaphorin interactions 1.067466e-04 3.972
R-HSA-9958790 SLC-mediated transport of inorganic anions 1.159734e-04 3.936
R-HSA-109581 Apoptosis 1.194684e-04 3.923
R-HSA-5357801 Programmed Cell Death 1.305869e-04 3.884
R-HSA-444257 RSK activation 2.195667e-04 3.658
R-HSA-69473 G2/M DNA damage checkpoint 2.309006e-04 3.637
R-HSA-8863678 Neurodegenerative Diseases 2.889802e-04 3.539
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... 2.889802e-04 3.539
R-HSA-68886 M Phase 3.101063e-04 3.508
R-HSA-9659379 Sensory processing of sound 3.157758e-04 3.501
R-HSA-400685 Sema4D in semaphorin signaling 3.268631e-04 3.486
R-HSA-69278 Cell Cycle, Mitotic 4.130707e-04 3.384
R-HSA-445095 Interaction between L1 and Ankyrins 4.130952e-04 3.384
R-HSA-3928663 EPHA-mediated growth cone collapse 4.130952e-04 3.384
R-HSA-9734009 Defective Intrinsic Pathway for Apoptosis 4.130952e-04 3.384
R-HSA-6802957 Oncogenic MAPK signaling 4.479665e-04 3.349
R-HSA-9614399 Regulation of localization of FOXO transcription factors 4.425257e-04 3.354
R-HSA-352238 Breakdown of the nuclear lamina 4.657529e-04 3.332
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 5.144535e-04 3.289
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 5.770142e-04 3.239
R-HSA-114452 Activation of BH3-only proteins 5.712489e-04 3.243
R-HSA-111465 Apoptotic cleavage of cellular proteins 6.979684e-04 3.156
R-HSA-2682334 EPH-Ephrin signaling 7.229604e-04 3.141
R-HSA-5696394 DNA Damage Recognition in GG-NER 8.433962e-04 3.074
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 9.153615e-04 3.038
R-HSA-380259 Loss of Nlp from mitotic centrosomes 9.153615e-04 3.038
R-HSA-8854518 AURKA Activation by TPX2 1.098407e-03 2.959
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 1.196179e-03 2.922
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 1.629670e-03 2.788
R-HSA-9656223 Signaling by RAF1 mutants 1.768221e-03 2.752
R-HSA-5674135 MAP2K and MAPK activation 1.768221e-03 2.752
R-HSA-380287 Centrosome maturation 1.811130e-03 2.742
R-HSA-9613829 Chaperone Mediated Autophagy 1.833665e-03 2.737
R-HSA-4419969 Depolymerization of the Nuclear Lamina 1.833665e-03 2.737
R-HSA-4420097 VEGFA-VEGFR2 Pathway 2.359607e-03 2.627
R-HSA-3928662 EPHB-mediated forward signaling 2.189974e-03 2.660
R-HSA-9649948 Signaling downstream of RAS mutants 2.506812e-03 2.601
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 2.506812e-03 2.601
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 2.506812e-03 2.601
R-HSA-6802949 Signaling by RAS mutants 2.506812e-03 2.601
R-HSA-75153 Apoptotic execution phase 2.506812e-03 2.601
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 2.563852e-03 2.591
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 2.815261e-03 2.550
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 2.815261e-03 2.550
R-HSA-2995383 Initiation of Nuclear Envelope (NE) Reformation 2.878685e-03 2.541
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 3.513901e-03 2.454
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 3.201952e-03 2.495
R-HSA-194138 Signaling by VEGF 3.517120e-03 2.454
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 3.521283e-03 2.453
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 3.836447e-03 2.416
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 3.861073e-03 2.413
R-HSA-9764265 Regulation of CDH1 Expression and Function 4.016203e-03 2.396
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 4.016203e-03 2.396
R-HSA-109606 Intrinsic Pathway for Apoptosis 4.570251e-03 2.340
R-HSA-2559583 Cellular Senescence 4.863723e-03 2.313
R-HSA-5336415 Uptake and function of diphtheria toxin 4.936060e-03 2.307
R-HSA-196025 Formation of annular gap junctions 5.932560e-03 2.227
R-HSA-9615710 Late endosomal microautophagy 5.906310e-03 2.229
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 5.906310e-03 2.229
R-HSA-6807878 COPI-mediated anterograde transport 5.300904e-03 2.276
R-HSA-69275 G2/M Transition 5.691906e-03 2.245
R-HSA-450294 MAP kinase activation 5.936029e-03 2.227
R-HSA-453274 Mitotic G2-G2/M phases 5.990160e-03 2.223
R-HSA-382556 ABC-family proteins mediated transport 6.164608e-03 2.210
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 6.255596e-03 2.204
R-HSA-190873 Gap junction degradation 7.012906e-03 2.154
R-HSA-5696398 Nucleotide Excision Repair 7.638979e-03 2.117
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 7.931389e-03 2.101
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 6.874414e-03 2.163
R-HSA-162588 Budding and maturation of HIV virion 6.874414e-03 2.163
R-HSA-8856828 Clathrin-mediated endocytosis 6.830518e-03 2.166
R-HSA-68877 Mitotic Prometaphase 6.786872e-03 2.168
R-HSA-9834752 Respiratory syncytial virus genome replication 7.012906e-03 2.154
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 7.301260e-03 2.137
R-HSA-9820962 Assembly and release of respiratory syncytial virus (RSV) virions 8.175294e-03 2.087
R-HSA-448424 Interleukin-17 signaling 9.030969e-03 2.044
R-HSA-8953897 Cellular responses to stimuli 9.065903e-03 2.043
R-HSA-5696400 Dual Incision in GG-NER 9.079009e-03 2.042
R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activ... 9.428752e-03 2.026
R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 9.837774e-03 2.007
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 1.004425e-02 1.998
R-HSA-3371511 HSF1 activation 1.031883e-02 1.986
R-HSA-9013694 Signaling by NOTCH4 1.069001e-02 1.971
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 1.073912e-02 1.969
R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 1.073912e-02 1.969
R-HSA-397014 Muscle contraction 1.077856e-02 1.967
R-HSA-5628897 TP53 Regulates Metabolic Genes 1.094965e-02 1.961
R-HSA-68882 Mitotic Anaphase 1.174684e-02 1.930
R-HSA-2555396 Mitotic Metaphase and Anaphase 1.199844e-02 1.921
R-HSA-3000484 Scavenging by Class F Receptors 1.213709e-02 1.916
R-HSA-418990 Adherens junctions interactions 1.225392e-02 1.912
R-HSA-5696395 Formation of Incision Complex in GG-NER 1.308020e-02 1.883
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 1.361017e-02 1.866
R-HSA-174490 Membrane binding and targetting of GAG proteins 1.361017e-02 1.866
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 1.515667e-02 1.819
R-HSA-399954 Sema3A PAK dependent Axon repulsion 1.677497e-02 1.775
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 1.555013e-02 1.808
R-HSA-1500620 Meiosis 1.622787e-02 1.790
R-HSA-187037 Signaling by NTRK1 (TRKA) 1.687946e-02 1.773
R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 1.361017e-02 1.866
R-HSA-446353 Cell-extracellular matrix interactions 1.677497e-02 1.775
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 1.471700e-02 1.832
R-HSA-9705683 SARS-CoV-2-host interactions 1.502898e-02 1.823
R-HSA-449147 Signaling by Interleukins 1.690760e-02 1.772
R-HSA-9645723 Diseases of programmed cell death 1.861469e-02 1.730
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 2.022050e-02 1.694
R-HSA-73893 DNA Damage Bypass 2.166711e-02 1.664
R-HSA-2262752 Cellular responses to stress 2.179189e-02 1.662
R-HSA-5083632 Defective C1GALT1C1 causes TNPS 2.204458e-02 1.657
R-HSA-2028269 Signaling by Hippo 2.204458e-02 1.657
R-HSA-421270 Cell-cell junction organization 2.306210e-02 1.637
R-HSA-381119 Unfolded Protein Response (UPR) 2.348669e-02 1.629
R-HSA-5339562 Uptake and actions of bacterial toxins 2.471837e-02 1.607
R-HSA-9709603 Impaired BRCA2 binding to PALB2 2.588763e-02 1.587
R-HSA-392517 Rap1 signalling 2.588763e-02 1.587
R-HSA-449836 Other interleukin signaling 2.588763e-02 1.587
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 2.679645e-02 1.572
R-HSA-975871 MyD88 cascade initiated on plasma membrane 2.703401e-02 1.568
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 2.703401e-02 1.568
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 2.703401e-02 1.568
R-HSA-5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tu... 3.045539e-02 1.516
R-HSA-5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neurop... 3.045539e-02 1.516
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 2.790361e-02 1.554
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 2.790361e-02 1.554
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 2.790361e-02 1.554
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 2.790361e-02 1.554
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 2.912835e-02 1.536
R-HSA-6782135 Dual incision in TC-NER 3.147915e-02 1.502
R-HSA-199977 ER to Golgi Anterograde Transport 2.892195e-02 1.539
R-HSA-2980766 Nuclear Envelope Breakdown 3.029164e-02 1.519
R-HSA-9612973 Autophagy 3.509477e-02 1.455
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 3.197285e-02 1.495
R-HSA-175474 Assembly Of The HIV Virion 3.211708e-02 1.493
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 2.998057e-02 1.523
R-HSA-166520 Signaling by NTRKs 2.957095e-02 1.529
R-HSA-1474244 Extracellular matrix organization 2.997752e-02 1.523
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 3.646739e-02 1.438
R-HSA-1266738 Developmental Biology 3.024180e-02 1.519
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 3.372916e-02 1.472
R-HSA-446728 Cell junction organization 3.579666e-02 1.446
R-HSA-9692914 SARS-CoV-1-host interactions 3.462805e-02 1.461
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 3.647005e-02 1.438
R-HSA-975155 MyD88 dependent cascade initiated on endosome 3.740787e-02 1.427
R-HSA-937061 TRIF (TICAM1)-mediated TLR4 signaling 3.836224e-02 1.416
R-HSA-166166 MyD88-independent TLR4 cascade 3.836224e-02 1.416
R-HSA-9665230 Drug resistance in ERBB2 KD mutants 4.040089e-02 1.394
R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 4.040089e-02 1.394
R-HSA-198765 Signalling to ERK5 4.040089e-02 1.394
R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 4.040089e-02 1.394
R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 4.040089e-02 1.394
R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 4.040089e-02 1.394
R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 4.040089e-02 1.394
R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 4.040089e-02 1.394
R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 4.040089e-02 1.394
R-HSA-9918454 Defective visual phototransduction due to ABCA4 loss of function 4.040089e-02 1.394
R-HSA-9665737 Drug resistance in ERBB2 TMD/JMD mutants 4.040089e-02 1.394
R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 4.040089e-02 1.394
R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 4.040089e-02 1.394
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 4.123044e-02 1.385
R-HSA-1482801 Acyl chain remodelling of PS 4.123044e-02 1.385
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 4.130872e-02 1.384
R-HSA-5685942 HDR through Homologous Recombination (HRR) 4.324430e-02 1.364
R-HSA-70635 Urea cycle 4.364377e-02 1.360
R-HSA-9022699 MECP2 regulates neuronal receptors and channels 4.364377e-02 1.360
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 4.438031e-02 1.353
R-HSA-264876 Insulin processing 4.610844e-02 1.336
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 4.977728e-02 1.303
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 4.977728e-02 1.303
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5.060130e-02 1.296
R-HSA-68875 Mitotic Prophase 5.089822e-02 1.293
R-HSA-9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 5.118663e-02 1.291
R-HSA-9709570 Impaired BRCA2 binding to RAD51 5.118663e-02 1.291
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 5.318150e-02 1.274
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 5.318150e-02 1.274
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 7.415178e-02 1.130
R-HSA-354192 Integrin signaling 6.190353e-02 1.208
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 5.528853e-02 1.257
R-HSA-8849472 PTK6 Down-Regulation 6.963301e-02 1.157
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 6.190353e-02 1.208
R-HSA-5693537 Resolution of D-Loop Structures 6.469250e-02 1.189
R-HSA-8937144 Aryl hydrocarbon receptor signalling 7.917898e-02 1.101
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 6.190353e-02 1.208
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 6.752303e-02 1.171
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 6.752303e-02 1.171
R-HSA-8856688 Golgi-to-ER retrograde transport 6.802893e-02 1.167
R-HSA-2129379 Molecules associated with elastic fibres 5.645492e-02 1.248
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 7.923834e-02 1.101
R-HSA-205025 NADE modulates death signalling 5.998867e-02 1.222
R-HSA-948021 Transport to the Golgi and subsequent modification 7.985262e-02 1.098
R-HSA-1566948 Elastic fibre formation 7.923834e-02 1.101
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 7.039398e-02 1.152
R-HSA-447038 NrCAM interactions 6.963301e-02 1.157
R-HSA-9664407 Parasite infection 8.042763e-02 1.095
R-HSA-9664422 FCGR3A-mediated phagocytosis 8.042763e-02 1.095
R-HSA-9664417 Leishmania phagocytosis 8.042763e-02 1.095
R-HSA-390466 Chaperonin-mediated protein folding 7.785254e-02 1.109
R-HSA-8853659 RET signaling 7.330425e-02 1.135
R-HSA-5250982 Toxicity of tetanus toxin (tetX) 5.998867e-02 1.222
R-HSA-5250989 Toxicity of botulinum toxin type G (botG) 6.963301e-02 1.157
R-HSA-9758919 Epithelial-Mesenchymal Transition (EMT) during gastrulation 7.917898e-02 1.101
R-HSA-416482 G alpha (12/13) signalling events 6.017570e-02 1.221
R-HSA-5617833 Cilium Assembly 6.641133e-02 1.178
R-HSA-438064 Post NMDA receptor activation events 7.785254e-02 1.109
R-HSA-1643685 Disease 7.799278e-02 1.108
R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... 7.039398e-02 1.152
R-HSA-1474165 Reproduction 6.541908e-02 1.184
R-HSA-168316 Assembly of Viral Components at the Budding Site 6.963301e-02 1.157
R-HSA-2995410 Nuclear Envelope (NE) Reassembly 6.354277e-02 1.197
R-HSA-1500931 Cell-Cell communication 6.051949e-02 1.218
R-HSA-1236974 ER-Phagosome pathway 8.163298e-02 1.088
R-HSA-8953750 Transcriptional Regulation by E2F6 8.226004e-02 1.085
R-HSA-9820965 Respiratory syncytial virus (RSV) genome replication, transcription and translat... 8.226004e-02 1.085
R-HSA-9646399 Aggrephagy 8.531676e-02 1.069
R-HSA-9604323 Negative regulation of NOTCH4 signaling 8.531676e-02 1.069
R-HSA-3371568 Attenuation phase 8.531676e-02 1.069
R-HSA-168256 Immune System 8.722749e-02 1.059
R-HSA-3214841 PKMTs methylate histone lysines 8.840749e-02 1.054
R-HSA-9645135 STAT5 Activation 8.862760e-02 1.052
R-HSA-447043 Neurofascin interactions 8.862760e-02 1.052
R-HSA-5250981 Toxicity of botulinum toxin type F (botF) 8.862760e-02 1.052
R-HSA-5250955 Toxicity of botulinum toxin type D (botD) 8.862760e-02 1.052
R-HSA-8964011 HDL clearance 8.862760e-02 1.052
R-HSA-9694516 SARS-CoV-2 Infection 8.886441e-02 1.051
R-HSA-391251 Protein folding 8.942657e-02 1.049
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 9.386663e-02 1.027
R-HSA-9730414 MITF-M-regulated melanocyte development 9.464172e-02 1.024
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 9.468695e-02 1.024
R-HSA-72731 Recycling of eIF2:GDP 9.797983e-02 1.009
R-HSA-9726840 SHOC2 M1731 mutant abolishes MRAS complex function 9.797983e-02 1.009
R-HSA-9660537 Signaling by MRAS-complex mutants 1.072367e-01 0.970
R-HSA-9726842 Gain-of-function MRAS complexes activate RAF signaling 1.072367e-01 0.970
R-HSA-390450 Folding of actin by CCT/TriC 1.254680e-01 0.901
R-HSA-202670 ERKs are inactivated 1.433293e-01 0.844
R-HSA-69166 Removal of the Flap Intermediate 1.694435e-01 0.771
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 1.864118e-01 0.730
R-HSA-176412 Phosphorylation of the APC/C 1.864118e-01 0.730
R-HSA-5083625 Defective GALNT3 causes HFTC 1.864118e-01 0.730
R-HSA-5083636 Defective GALNT12 causes CRCS1 1.864118e-01 0.730
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects 1.864118e-01 0.730
R-HSA-5678895 Defective CFTR causes cystic fibrosis 1.043365e-01 0.982
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 1.076107e-01 0.968
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 1.109121e-01 0.955
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1.277979e-01 0.893
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... 1.312449e-01 0.882
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... 1.312449e-01 0.882
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 1.382019e-01 0.859
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.417105e-01 0.849
R-HSA-72702 Ribosomal scanning and start codon recognition 1.417105e-01 0.849
R-HSA-913709 O-linked glycosylation of mucins 1.850894e-01 0.733
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 1.280058e-01 0.893
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... 1.850894e-01 0.733
R-HSA-69183 Processive synthesis on the lagging strand 1.779711e-01 0.750
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 1.608279e-01 0.794
R-HSA-5693538 Homology Directed Repair 1.564687e-01 0.806
R-HSA-76009 Platelet Aggregation (Plug Formation) 1.043365e-01 0.982
R-HSA-432722 Golgi Associated Vesicle Biogenesis 1.312449e-01 0.882
R-HSA-69618 Mitotic Spindle Checkpoint 1.080362e-01 0.966
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 1.419950e-01 0.848
R-HSA-6798695 Neutrophil degranulation 1.227301e-01 0.911
R-HSA-5693548 Sensing of DNA Double Strand Breaks 1.433293e-01 0.844
R-HSA-72737 Cap-dependent Translation Initiation 1.515933e-01 0.819
R-HSA-204005 COPII-mediated vesicle transport 1.925007e-01 0.716
R-HSA-2467813 Separation of Sister Chromatids 1.201706e-01 0.920
R-HSA-72613 Eukaryotic Translation Initiation 1.515933e-01 0.819
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 1.076107e-01 0.968
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 9.958798e-02 1.002
R-HSA-9007101 Rab regulation of trafficking 1.540248e-01 0.812
R-HSA-192905 vRNP Assembly 1.344444e-01 0.871
R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 1.521234e-01 0.818
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.608279e-01 0.794
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 1.608279e-01 0.794
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 1.347131e-01 0.871
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 1.631350e-01 0.787
R-HSA-9925563 Developmental Lineage of Pancreatic Ductal Cells 1.887900e-01 0.724
R-HSA-170968 Frs2-mediated activation 1.608279e-01 0.794
R-HSA-430116 GP1b-IX-V activation signalling 1.163991e-01 0.934
R-HSA-169893 Prolonged ERK activation events 1.864118e-01 0.730
R-HSA-69239 Synthesis of DNA 1.257248e-01 0.901
R-HSA-73894 DNA Repair 9.974346e-02 1.001
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 1.631350e-01 0.787
R-HSA-170984 ARMS-mediated activation 1.163991e-01 0.934
R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... 1.254680e-01 0.901
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.779711e-01 0.750
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 1.109121e-01 0.955
R-HSA-983189 Kinesins 1.559273e-01 0.807
R-HSA-425381 Bicarbonate transporters 1.344444e-01 0.871
R-HSA-877312 Regulation of IFNG signaling 1.521234e-01 0.818
R-HSA-69091 Polymerase switching 1.521234e-01 0.818
R-HSA-69109 Leading Strand Synthesis 1.521234e-01 0.818
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 1.779711e-01 0.750
R-HSA-3371571 HSF1-dependent transactivation 1.243732e-01 0.905
R-HSA-445355 Smooth Muscle Contraction 1.312449e-01 0.882
R-HSA-69002 DNA Replication Pre-Initiation 1.303017e-01 0.885
R-HSA-69306 DNA Replication 1.017647e-01 0.992
R-HSA-3371556 Cellular response to heat stress 1.638721e-01 0.785
R-HSA-1236975 Antigen processing-Cross presentation 1.280058e-01 0.893
R-HSA-447041 CHL1 interactions 9.797983e-02 1.009
R-HSA-5250958 Toxicity of botulinum toxin type B (botB) 1.072367e-01 0.970
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 1.163991e-01 0.934
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 1.694435e-01 0.771
R-HSA-3270619 IRF3-mediated induction of type I IFN 1.779711e-01 0.750
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 1.779711e-01 0.750
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 1.864118e-01 0.730
R-HSA-190828 Gap junction trafficking 1.010905e-01 0.995
R-HSA-912446 Meiotic recombination 1.243732e-01 0.905
R-HSA-9734767 Developmental Cell Lineages 1.694672e-01 0.771
R-HSA-9840373 Cellular response to mitochondrial stress 1.163991e-01 0.934
R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 1.521234e-01 0.818
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 1.694435e-01 0.771
R-HSA-157858 Gap junction trafficking and regulation 1.175933e-01 0.930
R-HSA-1221632 Meiotic synapsis 1.312449e-01 0.882
R-HSA-9675135 Diseases of DNA repair 1.076107e-01 0.968
R-HSA-210990 PECAM1 interactions 1.344444e-01 0.871
R-HSA-9856872 Malate-aspartate shuttle 1.694435e-01 0.771
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 1.257248e-01 0.901
R-HSA-9700206 Signaling by ALK in cancer 1.257248e-01 0.901
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 1.452381e-01 0.838
R-HSA-8983432 Interleukin-15 signaling 1.521234e-01 0.818
R-HSA-9662834 CD163 mediating an anti-inflammatory response 1.344444e-01 0.871
R-HSA-3928665 EPH-ephrin mediated repulsion of cells 1.109121e-01 0.955
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 1.072367e-01 0.970
R-HSA-9855142 Cellular responses to mechanical stimuli 1.419950e-01 0.848
R-HSA-9860931 Response of endothelial cells to shear stress 1.167532e-01 0.933
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 1.123620e-01 0.949
R-HSA-9679191 Potential therapeutics for SARS 9.698962e-02 1.013
R-HSA-1280215 Cytokine Signaling in Immune system 1.601412e-01 0.795
R-HSA-168268 Virus Assembly and Release 1.864118e-01 0.730
R-HSA-168249 Innate Immune System 1.031027e-01 0.987
R-HSA-9614085 FOXO-mediated transcription 1.058984e-01 0.975
R-HSA-9759194 Nuclear events mediated by NFE2L2 1.638721e-01 0.785
R-HSA-3700989 Transcriptional Regulation by TP53 1.312009e-01 0.882
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 1.740550e-01 0.759
R-HSA-168898 Toll-like Receptor Cascades 1.727031e-01 0.763
R-HSA-9679506 SARS-CoV Infections 1.425789e-01 0.846
R-HSA-9678108 SARS-CoV-1 Infection 1.417550e-01 0.848
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.947663e-01 0.710
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anapha... 1.947663e-01 0.710
R-HSA-9702518 STAT5 activation downstream of FLT3 ITD mutants 1.947663e-01 0.710
R-HSA-453276 Regulation of mitotic cell cycle 1.962211e-01 0.707
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 1.962211e-01 0.707
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 1.962211e-01 0.707
R-HSA-199992 trans-Golgi Network Vesicle Budding 1.999505e-01 0.699
R-HSA-9924644 Developmental Lineages of the Mammary Gland 1.999505e-01 0.699
R-HSA-9824443 Parasitic Infection Pathways 2.008326e-01 0.697
R-HSA-9658195 Leishmania infection 2.008326e-01 0.697
R-HSA-5637810 Constitutive Signaling by EGFRvIII 2.030355e-01 0.692
R-HSA-5637812 Signaling by EGFRvIII in Cancer 2.030355e-01 0.692
R-HSA-174437 Removal of the Flap Intermediate from the C-strand 2.030355e-01 0.692
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 2.030355e-01 0.692
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 2.030355e-01 0.692
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 2.030355e-01 0.692
R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 2.030355e-01 0.692
R-HSA-69052 Switching of origins to a post-replicative state 2.036884e-01 0.691
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 2.036884e-01 0.691
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 2.112203e-01 0.675
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 2.112203e-01 0.675
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 2.112203e-01 0.675
R-HSA-9665348 Signaling by ERBB2 ECD mutants 2.112203e-01 0.675
R-HSA-5358508 Mismatch Repair 2.112203e-01 0.675
R-HSA-5689603 UCH proteinases 2.149471e-01 0.668
R-HSA-9020591 Interleukin-12 signaling 2.149471e-01 0.668
R-HSA-5673001 RAF/MAP kinase cascade 2.153734e-01 0.667
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 2.185956e-01 0.660
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 2.193215e-01 0.659
R-HSA-844456 The NLRP3 inflammasome 2.193215e-01 0.659
R-HSA-1480926 O2/CO2 exchange in erythrocytes 2.193215e-01 0.659
R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 2.193215e-01 0.659
R-HSA-9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 2.193215e-01 0.659
R-HSA-1834941 STING mediated induction of host immune responses 2.193215e-01 0.659
R-HSA-5619084 ABC transporter disorders 2.224853e-01 0.653
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 2.273400e-01 0.643
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 2.273400e-01 0.643
R-HSA-445144 Signal transduction by L1 2.273400e-01 0.643
R-HSA-6807004 Negative regulation of MET activity 2.273400e-01 0.643
R-HSA-5684996 MAPK1/MAPK3 signaling 2.283632e-01 0.641
R-HSA-162599 Late Phase of HIV Life Cycle 2.290169e-01 0.640
R-HSA-5693607 Processing of DNA double-strand break ends 2.338305e-01 0.631
R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 2.352767e-01 0.628
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 2.352767e-01 0.628
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 2.352767e-01 0.628
R-HSA-69186 Lagging Strand Synthesis 2.352767e-01 0.628
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 2.352767e-01 0.628
R-HSA-5357786 TNFR1-induced proapoptotic signaling 2.352767e-01 0.628
R-HSA-8951664 Neddylation 2.382543e-01 0.623
R-HSA-983169 Class I MHC mediated antigen processing & presentation 2.393686e-01 0.621
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 2.431323e-01 0.614
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 2.431323e-01 0.614
R-HSA-211979 Eicosanoids 2.431323e-01 0.614
R-HSA-211958 Miscellaneous substrates 2.431323e-01 0.614
R-HSA-69242 S Phase 2.453457e-01 0.610
R-HSA-8878171 Transcriptional regulation by RUNX1 2.493534e-01 0.603
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 2.509077e-01 0.600
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 2.509077e-01 0.600
R-HSA-166208 mTORC1-mediated signalling 2.509077e-01 0.600
R-HSA-912694 Regulation of IFNA/IFNB signaling 2.509077e-01 0.600
R-HSA-168799 Neurotoxicity of clostridium toxins 2.509077e-01 0.600
R-HSA-162906 HIV Infection 2.515869e-01 0.599
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 2.528086e-01 0.597
R-HSA-141424 Amplification of signal from the kinetochores 2.528086e-01 0.597
R-HSA-9755511 KEAP1-NFE2L2 pathway 2.535800e-01 0.596
R-HSA-9820448 Developmental Cell Lineages of the Exocrine Pancreas 2.563338e-01 0.591
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 2.566105e-01 0.591
R-HSA-381038 XBP1(S) activates chaperone genes 2.566105e-01 0.591
R-HSA-977068 Termination of O-glycan biosynthesis 2.586037e-01 0.587
R-HSA-912526 Interleukin receptor SHC signaling 2.586037e-01 0.587
R-HSA-211935 Fatty acids 2.586037e-01 0.587
R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 2.586037e-01 0.587
R-HSA-1369062 ABC transporters in lipid homeostasis 2.586037e-01 0.587
R-HSA-3000170 Syndecan interactions 2.586037e-01 0.587
R-HSA-982772 Growth hormone receptor signaling 2.586037e-01 0.587
R-HSA-5693532 DNA Double-Strand Break Repair 2.590919e-01 0.587
R-HSA-447115 Interleukin-12 family signaling 2.604135e-01 0.584
R-HSA-73887 Death Receptor Signaling 2.618540e-01 0.582
R-HSA-9663891 Selective autophagy 2.642171e-01 0.578
R-HSA-9703648 Signaling by FLT3 ITD and TKD mutants 2.662211e-01 0.575
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 2.662211e-01 0.575
R-HSA-9665686 Signaling by ERBB2 TMD/JMD mutants 2.662211e-01 0.575
R-HSA-9836573 Mitochondrial RNA degradation 2.662211e-01 0.575
R-HSA-162582 Signal Transduction 2.673696e-01 0.573
R-HSA-162587 HIV Life Cycle 2.701628e-01 0.568
R-HSA-9932451 SWI/SNF chromatin remodelers 2.737608e-01 0.563
R-HSA-9932444 ATP-dependent chromatin remodelers 2.737608e-01 0.563
R-HSA-174411 Polymerase switching on the C-strand of the telomere 2.737608e-01 0.563
R-HSA-2453864 Retinoid cycle disease events 2.737608e-01 0.563
R-HSA-9675143 Diseases of the neuronal system 2.737608e-01 0.563
R-HSA-2474795 Diseases associated with visual transduction 2.737608e-01 0.563
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 2.737608e-01 0.563
R-HSA-1852241 Organelle biogenesis and maintenance 2.744760e-01 0.561
R-HSA-8986944 Transcriptional Regulation by MECP2 2.756278e-01 0.560
R-HSA-381070 IRE1alpha activates chaperones 2.794299e-01 0.554
R-HSA-112315 Transmission across Chemical Synapses 2.803819e-01 0.552
R-HSA-157118 Signaling by NOTCH 2.809773e-01 0.551
R-HSA-1643713 Signaling by EGFR in Cancer 2.812234e-01 0.551
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 2.812234e-01 0.551
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 2.812234e-01 0.551
R-HSA-9703465 Signaling by FLT3 fusion proteins 2.812234e-01 0.551
R-HSA-74752 Signaling by Insulin receptor 2.832308e-01 0.548
R-HSA-68867 Assembly of the pre-replicative complex 2.870300e-01 0.542
R-HSA-174414 Processive synthesis on the C-strand of the telomere 2.886097e-01 0.540
R-HSA-5357956 TNFR1-induced NF-kappa-B signaling pathway 2.886097e-01 0.540
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 2.946218e-01 0.531
R-HSA-77387 Insulin receptor recycling 2.959207e-01 0.529
R-HSA-622312 Inflammasomes 2.959207e-01 0.529
R-HSA-9824446 Viral Infection Pathways 2.964888e-01 0.528
R-HSA-5619115 Disorders of transmembrane transporters 2.970270e-01 0.527
R-HSA-9664565 Signaling by ERBB2 KD Mutants 3.031569e-01 0.518
R-HSA-5656169 Termination of translesion DNA synthesis 3.031569e-01 0.518
R-HSA-9674555 Signaling by CSF3 (G-CSF) 3.031569e-01 0.518
R-HSA-446203 Asparagine N-linked glycosylation 3.074496e-01 0.512
R-HSA-68962 Activation of the pre-replicative complex 3.103192e-01 0.508
R-HSA-76046 RNA Polymerase III Transcription Initiation 3.103192e-01 0.508
R-HSA-1227990 Signaling by ERBB2 in Cancer 3.103192e-01 0.508
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 3.103192e-01 0.508
R-HSA-888590 GABA synthesis, release, reuptake and degradation 3.103192e-01 0.508
R-HSA-8863795 Downregulation of ERBB2 signaling 3.103192e-01 0.508
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 3.103192e-01 0.508
R-HSA-193704 p75 NTR receptor-mediated signalling 3.135473e-01 0.504
R-HSA-5688426 Deubiquitination 3.155065e-01 0.501
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 3.174084e-01 0.498
R-HSA-399719 Trafficking of AMPA receptors 3.174084e-01 0.498
R-HSA-5694530 Cargo concentration in the ER 3.174084e-01 0.498
R-HSA-8963693 Aspartate and asparagine metabolism 3.174084e-01 0.498
R-HSA-5689880 Ub-specific processing proteases 3.176726e-01 0.498
R-HSA-983231 Factors involved in megakaryocyte development and platelet production 3.232864e-01 0.490
R-HSA-69190 DNA strand elongation 3.244251e-01 0.489
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 3.244251e-01 0.489
R-HSA-9675126 Diseases of mitotic cell cycle 3.244251e-01 0.489
R-HSA-5683057 MAPK family signaling cascades 3.284092e-01 0.484
R-HSA-176187 Activation of ATR in response to replication stress 3.313701e-01 0.480
R-HSA-1839124 FGFR1 mutant receptor activation 3.313701e-01 0.480
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 3.313701e-01 0.480
R-HSA-5675482 Regulation of necroptotic cell death 3.313701e-01 0.480
R-HSA-416476 G alpha (q) signalling events 3.364134e-01 0.473
R-HSA-1482788 Acyl chain remodelling of PC 3.382441e-01 0.471
R-HSA-180534 Vpu mediated degradation of CD4 3.382441e-01 0.471
R-HSA-8964539 Glutamate and glutamine metabolism 3.382441e-01 0.471
R-HSA-5223345 Miscellaneous transport and binding events 3.382441e-01 0.471
R-HSA-382551 Transport of small molecules 3.386199e-01 0.470
R-HSA-5673000 RAF activation 3.450479e-01 0.462
R-HSA-203615 eNOS activation 3.450479e-01 0.462
R-HSA-901042 Calnexin/calreticulin cycle 3.450479e-01 0.462
R-HSA-9680350 Signaling by CSF1 (M-CSF) in myeloid cells 3.450479e-01 0.462
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 3.450479e-01 0.462
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 3.450479e-01 0.462
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3.450479e-01 0.462
R-HSA-9734779 Developmental Cell Lineages of the Integumentary System 3.510331e-01 0.455
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 3.517821e-01 0.454
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 3.517821e-01 0.454
R-HSA-187687 Signalling to ERKs 3.517821e-01 0.454
R-HSA-1482839 Acyl chain remodelling of PE 3.517821e-01 0.454
R-HSA-169911 Regulation of Apoptosis 3.517821e-01 0.454
R-HSA-381042 PERK regulates gene expression 3.517821e-01 0.454
R-HSA-9772755 Formation of WDR5-containing histone-modifying complexes 3.517821e-01 0.454
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 3.547466e-01 0.450
R-HSA-432720 Lysosome Vesicle Biogenesis 3.584475e-01 0.446
R-HSA-74158 RNA Polymerase III Transcription 3.584475e-01 0.446
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 3.584475e-01 0.446
R-HSA-9682385 FLT3 signaling in disease 3.584475e-01 0.446
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 3.584475e-01 0.446
R-HSA-180585 Vif-mediated degradation of APOBEC3G 3.584475e-01 0.446
R-HSA-76002 Platelet activation, signaling and aggregation 3.597122e-01 0.444
R-HSA-4641258 Degradation of DVL 3.650448e-01 0.438
R-HSA-4641257 Degradation of AXIN 3.650448e-01 0.438
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 3.650448e-01 0.438
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 3.650448e-01 0.438
R-HSA-392499 Metabolism of proteins 3.680659e-01 0.434
R-HSA-597592 Post-translational protein modification 3.705871e-01 0.431
R-HSA-202131 Metabolism of nitric oxide: NOS3 activation and regulation 3.715747e-01 0.430
R-HSA-5213460 RIPK1-mediated regulated necrosis 3.715747e-01 0.430
R-HSA-9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 3.780378e-01 0.422
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 3.780378e-01 0.422
R-HSA-69541 Stabilization of p53 3.780378e-01 0.422
R-HSA-71336 Pentose phosphate pathway 3.780378e-01 0.422
R-HSA-8964043 Plasma lipoprotein clearance 3.780378e-01 0.422
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 3.783482e-01 0.422
R-HSA-8941858 Regulation of RUNX3 expression and activity 3.844348e-01 0.415
R-HSA-451927 Interleukin-2 family signaling 3.844348e-01 0.415
R-HSA-8953854 Metabolism of RNA 3.887681e-01 0.410
R-HSA-5218920 VEGFR2 mediated vascular permeability 3.907664e-01 0.408
R-HSA-9607240 FLT3 Signaling 3.907664e-01 0.408
R-HSA-9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 3.907664e-01 0.408
R-HSA-5362768 Hh mutants are degraded by ERAD 3.907664e-01 0.408
R-HSA-73933 Resolution of Abasic Sites (AP sites) 3.907664e-01 0.408
R-HSA-5676590 NIK-->noncanonical NF-kB signaling 3.907664e-01 0.408
R-HSA-8853884 Transcriptional Regulation by VENTX 3.907664e-01 0.408
R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... 3.907664e-01 0.408
R-HSA-2980736 Peptide hormone metabolism 3.914367e-01 0.407
R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 3.970333e-01 0.401
R-HSA-9932298 Degradation of CRY and PER proteins 3.970333e-01 0.401
R-HSA-5610780 Degradation of GLI1 by the proteasome 3.970333e-01 0.401
R-HSA-3000480 Scavenging by Class A Receptors 3.970333e-01 0.401
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 3.970333e-01 0.401
R-HSA-5610783 Degradation of GLI2 by the proteasome 3.970333e-01 0.401
R-HSA-5675221 Negative regulation of MAPK pathway 3.970333e-01 0.401
R-HSA-5655302 Signaling by FGFR1 in disease 3.970333e-01 0.401
R-HSA-5663205 Infectious disease 4.028869e-01 0.395
R-HSA-165159 MTOR signalling 4.032361e-01 0.394
R-HSA-73886 Chromosome Maintenance 4.058568e-01 0.392
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 4.058568e-01 0.392
R-HSA-5387390 Hh mutants abrogate ligand secretion 4.093755e-01 0.388
R-HSA-1433557 Signaling by SCF-KIT 4.093755e-01 0.388
R-HSA-2173789 TGF-beta receptor signaling activates SMADs 4.093755e-01 0.388
R-HSA-2132295 MHC class II antigen presentation 4.130059e-01 0.384
R-HSA-9907900 Proteasome assembly 4.154521e-01 0.381
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 4.154521e-01 0.381
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 4.154521e-01 0.381
R-HSA-373752 Netrin-1 signaling 4.154521e-01 0.381
R-HSA-5683826 Surfactant metabolism 4.154521e-01 0.381
R-HSA-774815 Nucleosome assembly 4.214666e-01 0.375
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 4.214666e-01 0.375
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 4.214666e-01 0.375
R-HSA-4608870 Asymmetric localization of PCP proteins 4.214666e-01 0.375
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 4.214666e-01 0.375
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 4.214666e-01 0.375
R-HSA-69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 4.214666e-01 0.375
R-HSA-69613 p53-Independent G1/S DNA Damage Checkpoint 4.214666e-01 0.375
R-HSA-9824272 Somitogenesis 4.214666e-01 0.375
R-HSA-1614558 Degradation of cysteine and homocysteine 4.214666e-01 0.375
R-HSA-69206 G1/S Transition 4.236498e-01 0.373
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 4.274195e-01 0.369
R-HSA-5357905 Regulation of TNFR1 signaling 4.274195e-01 0.369
R-HSA-9664424 Cell recruitment (pro-inflammatory response) 4.274195e-01 0.369
R-HSA-9660826 Purinergic signaling in leishmaniasis infection 4.274195e-01 0.369
R-HSA-114608 Platelet degranulation 4.306907e-01 0.366
R-HSA-425407 SLC-mediated transmembrane transport 4.320825e-01 0.364
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 4.391433e-01 0.357
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 4.449154e-01 0.352
R-HSA-9766229 Degradation of CDH1 4.449154e-01 0.352
R-HSA-389661 Glyoxylate metabolism and glycine degradation 4.449154e-01 0.352
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 4.449154e-01 0.352
R-HSA-69563 p53-Dependent G1 DNA Damage Response 4.449154e-01 0.352
R-HSA-5658442 Regulation of RAS by GAPs 4.506285e-01 0.346
R-HSA-109704 PI3K Cascade 4.506285e-01 0.346
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 4.549696e-01 0.342
R-HSA-1169091 Activation of NF-kappaB in B cells 4.562831e-01 0.341
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 4.562831e-01 0.341
R-HSA-5358346 Hedgehog ligand biogenesis 4.562831e-01 0.341
R-HSA-212436 Generic Transcription Pathway 4.564472e-01 0.341
R-HSA-72187 mRNA 3'-end processing 4.618799e-01 0.335
R-HSA-68949 Orc1 removal from chromatin 4.618799e-01 0.335
R-HSA-9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 4.618799e-01 0.335
R-HSA-6794361 Neurexins and neuroligins 4.618799e-01 0.335
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 4.674194e-01 0.330
R-HSA-8948751 Regulation of PTEN stability and activity 4.674194e-01 0.330
R-HSA-9018519 Estrogen-dependent gene expression 4.685771e-01 0.329
R-HSA-5173105 O-linked glycosylation 4.719475e-01 0.326
R-HSA-9820952 Respiratory Syncytial Virus Infection Pathway 4.719475e-01 0.326
R-HSA-72649 Translation initiation complex formation 4.729022e-01 0.325
R-HSA-9754678 SARS-CoV-2 modulates host translation machinery 4.729022e-01 0.325
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 4.783289e-01 0.320
R-HSA-75893 TNF signaling 4.837001e-01 0.315
R-HSA-193648 NRAGE signals death through JNK 4.837001e-01 0.315
R-HSA-1632852 Macroautophagy 4.853011e-01 0.314
R-HSA-3247509 Chromatin modifying enzymes 4.874069e-01 0.312
R-HSA-112399 IRS-mediated signalling 4.890162e-01 0.311
R-HSA-5621480 Dectin-2 family 4.890162e-01 0.311
R-HSA-74160 Gene expression (Transcription) 4.894537e-01 0.310
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 4.918996e-01 0.308
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... 4.942780e-01 0.306
R-HSA-194441 Metabolism of non-coding RNA 4.994860e-01 0.301
R-HSA-191859 snRNP Assembly 4.994860e-01 0.301
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 4.994860e-01 0.301
R-HSA-180786 Extension of Telomeres 4.994860e-01 0.301
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 5.046406e-01 0.297
R-HSA-1227986 Signaling by ERBB2 5.046406e-01 0.297
R-HSA-351202 Metabolism of polyamines 5.046406e-01 0.297
R-HSA-73857 RNA Polymerase II Transcription 5.047338e-01 0.297
R-HSA-453279 Mitotic G1 phase and G1/S transition 5.049368e-01 0.297
R-HSA-73856 RNA Polymerase II Transcription Termination 5.097424e-01 0.293
R-HSA-8939902 Regulation of RUNX2 expression and activity 5.097424e-01 0.293
R-HSA-2428928 IRS-related events triggered by IGF1R 5.097424e-01 0.293
R-HSA-9793380 Formation of paraxial mesoderm 5.097424e-01 0.293
R-HSA-9758941 Gastrulation 5.145727e-01 0.289
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 5.177573e-01 0.286
R-HSA-6790901 rRNA modification in the nucleus and cytosol 5.197899e-01 0.284
R-HSA-69615 G1/S DNA Damage Checkpoints 5.197899e-01 0.284
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases 5.197899e-01 0.284
R-HSA-8848021 Signaling by PTK6 5.197899e-01 0.284
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 5.247367e-01 0.280
R-HSA-2428924 IGF1R signaling cascade 5.247367e-01 0.280
R-HSA-74751 Insulin receptor signalling cascade 5.247367e-01 0.280
R-HSA-4839726 Chromatin organization 5.256556e-01 0.279
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 5.296327e-01 0.276
R-HSA-1234174 Cellular response to hypoxia 5.296327e-01 0.276
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 5.344787e-01 0.272
R-HSA-5693606 DNA Double Strand Break Response 5.392750e-01 0.268
R-HSA-9610379 HCMV Late Events 5.396605e-01 0.268
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... 5.440222e-01 0.264
R-HSA-5218859 Regulated Necrosis 5.440222e-01 0.264
R-HSA-1280218 Adaptive Immune System 5.441391e-01 0.264
R-HSA-5633007 Regulation of TP53 Activity 5.488367e-01 0.261
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 5.533712e-01 0.257
R-HSA-69202 Cyclin E associated events during G1/S transition 5.533712e-01 0.257
R-HSA-195253 Degradation of beta-catenin by the destruction complex 5.533712e-01 0.257
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 5.533712e-01 0.257
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 5.579740e-01 0.253
R-HSA-3000178 ECM proteoglycans 5.579740e-01 0.253
R-HSA-8978934 Metabolism of cofactors 5.579740e-01 0.253
R-HSA-5632684 Hedgehog 'on' state 5.579740e-01 0.253
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 5.625297e-01 0.250
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 5.670387e-01 0.246
R-HSA-112316 Neuronal System 5.694554e-01 0.245
R-HSA-5619102 SLC transporter disorders 5.697492e-01 0.244
R-HSA-1226099 Signaling by FGFR in disease 5.715014e-01 0.243
R-HSA-9711123 Cellular response to chemical stress 5.717834e-01 0.243
R-HSA-5621481 C-type lectin receptors (CLRs) 5.842556e-01 0.233
R-HSA-9909648 Regulation of PD-L1(CD274) expression 5.871136e-01 0.231
R-HSA-216083 Integrin cell surface interactions 5.889000e-01 0.230
R-HSA-4086400 PCP/CE pathway 5.889000e-01 0.230
R-HSA-9925561 Developmental Lineage of Pancreatic Acinar Cells 5.931387e-01 0.227
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 5.972000e-01 0.224
R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... 5.973340e-01 0.224
R-HSA-9833482 PKR-mediated signaling 5.973340e-01 0.224
R-HSA-6806834 Signaling by MET 5.973340e-01 0.224
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 6.055961e-01 0.218
R-HSA-168255 Influenza Infection 6.067145e-01 0.217
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 6.096637e-01 0.215
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 6.136897e-01 0.212
R-HSA-201681 TCF dependent signaling in response to WNT 6.175968e-01 0.209
R-HSA-6794362 Protein-protein interactions at synapses 6.176743e-01 0.209
R-HSA-5687128 MAPK6/MAPK4 signaling 6.176743e-01 0.209
R-HSA-3781865 Diseases of glycosylation 6.202812e-01 0.207
R-HSA-9909615 Regulation of PD-L1(CD274) Post-translational modification 6.216181e-01 0.206
R-HSA-1614635 Sulfur amino acid metabolism 6.255215e-01 0.204
R-HSA-70268 Pyruvate metabolism 6.293848e-01 0.201
R-HSA-112310 Neurotransmitter release cycle 6.407387e-01 0.193
R-HSA-73884 Base Excision Repair 6.407387e-01 0.193
R-HSA-202424 Downstream TCR signaling 6.407387e-01 0.193
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 6.412388e-01 0.193
R-HSA-72163 mRNA Splicing - Major Pathway 6.463348e-01 0.190
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 6.517468e-01 0.186
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 6.588986e-01 0.181
R-HSA-389948 Co-inhibition by PD-1 6.612816e-01 0.180
R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 6.659044e-01 0.177
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 6.685642e-01 0.175
R-HSA-1483206 Glycerophospholipid biosynthesis 6.685642e-01 0.175
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 6.693534e-01 0.174
R-HSA-5607764 CLEC7A (Dectin-1) signaling 6.693534e-01 0.174
R-HSA-157579 Telomere Maintenance 6.727671e-01 0.172
R-HSA-8878159 Transcriptional regulation by RUNX3 6.727671e-01 0.172
R-HSA-170834 Signaling by TGF-beta Receptor Complex 6.727671e-01 0.172
R-HSA-72172 mRNA Splicing 6.733492e-01 0.172
R-HSA-8957275 Post-translational protein phosphorylation 6.761458e-01 0.170
R-HSA-422356 Regulation of insulin secretion 6.761458e-01 0.170
R-HSA-3214847 HATs acetylate histones 6.794897e-01 0.168
R-HSA-5610787 Hedgehog 'off' state 6.827994e-01 0.166
R-HSA-72766 Translation 6.843291e-01 0.165
R-HSA-9009391 Extra-nuclear estrogen signaling 6.860750e-01 0.164
R-HSA-9020702 Interleukin-1 signaling 6.860750e-01 0.164
R-HSA-9842860 Regulation of endogenous retroelements 6.893171e-01 0.162
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 6.893171e-01 0.162
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 6.957017e-01 0.158
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 6.988449e-01 0.156
R-HSA-5619507 Activation of HOX genes during differentiation 6.988449e-01 0.156
R-HSA-211000 Gene Silencing by RNA 7.080822e-01 0.150
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 7.110983e-01 0.148
R-HSA-388396 GPCR downstream signalling 7.163614e-01 0.145
R-HSA-202403 TCR signaling 7.170379e-01 0.144
R-HSA-109582 Hemostasis 7.283629e-01 0.138
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... 7.313610e-01 0.136
R-HSA-909733 Interferon alpha/beta signaling 7.368864e-01 0.133
R-HSA-8939211 ESR-mediated signaling 7.444769e-01 0.128
R-HSA-2219528 PI3K/AKT Signaling in Cancer 7.449634e-01 0.128
R-HSA-8878166 Transcriptional regulation by RUNX2 7.476005e-01 0.126
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 7.578809e-01 0.120
R-HSA-162909 Host Interactions of HIV factors 7.603852e-01 0.119
R-HSA-977606 Regulation of Complement cascade 7.628639e-01 0.118
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 7.653170e-01 0.116
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 7.653170e-01 0.116
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 7.653170e-01 0.116
R-HSA-9609646 HCMV Infection 7.686579e-01 0.114
R-HSA-199418 Negative regulation of the PI3K/AKT network 7.772094e-01 0.109
R-HSA-388841 Regulation of T cell activation by CD28 family 7.791357e-01 0.108
R-HSA-9909396 Circadian clock 7.840553e-01 0.106
R-HSA-3858494 Beta-catenin independent WNT signaling 7.950035e-01 0.100
R-HSA-163685 Integration of energy metabolism 7.950035e-01 0.100
R-HSA-9824439 Bacterial Infection Pathways 7.983279e-01 0.098
R-HSA-9948299 Ribosome-associated quality control 7.992267e-01 0.097
R-HSA-5358351 Signaling by Hedgehog 7.992267e-01 0.097
R-HSA-6807070 PTEN Regulation 8.013057e-01 0.096
R-HSA-372790 Signaling by GPCR 8.054508e-01 0.094
R-HSA-2871837 FCERI mediated NF-kB activation 8.133381e-01 0.090
R-HSA-211945 Phase I - Functionalization of compounds 8.140918e-01 0.089
R-HSA-166658 Complement cascade 8.152719e-01 0.089
R-HSA-2187338 Visual phototransduction 8.190799e-01 0.087
R-HSA-9856651 MITF-M-dependent gene expression 8.246460e-01 0.084
R-HSA-9010553 Regulation of expression of SLITs and ROBOs 8.282619e-01 0.082
R-HSA-2142753 Arachidonate metabolism 8.282619e-01 0.082
R-HSA-446652 Interleukin-1 family signaling 8.282619e-01 0.082
R-HSA-9609507 Protein localization 8.300419e-01 0.081
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 8.318036e-01 0.080
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 8.318036e-01 0.080
R-HSA-168273 Influenza Viral RNA Transcription and Replication 8.335472e-01 0.079
R-HSA-1483257 Phospholipid metabolism 8.376495e-01 0.077
R-HSA-1257604 PIP3 activates AKT signaling 8.376495e-01 0.077
R-HSA-9711097 Cellular response to starvation 8.386708e-01 0.076
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 8.386708e-01 0.076
R-HSA-877300 Interferon gamma signaling 8.403436e-01 0.076
R-HSA-195721 Signaling by WNT 8.415172e-01 0.075
R-HSA-9006936 Signaling by TGFB family members 8.419991e-01 0.075
R-HSA-211897 Cytochrome P450 - arranged by substrate type 8.531197e-01 0.069
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 8.634621e-01 0.064
R-HSA-9664433 Leishmania parasite growth and survival 8.634621e-01 0.064
R-HSA-611105 Respiratory electron transport 8.704031e-01 0.060
R-HSA-212165 Epigenetic regulation of gene expression 8.706489e-01 0.060
R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.832502e-01 0.054
R-HSA-1428517 Aerobic respiration and respiratory electron transport 8.885014e-01 0.051
R-HSA-9006925 Intracellular signaling by second messengers 8.894234e-01 0.051
R-HSA-71291 Metabolism of amino acids and derivatives 8.987209e-01 0.046
R-HSA-376176 Signaling by ROBO receptors 9.001852e-01 0.046
R-HSA-9006931 Signaling by Nuclear Receptors 9.072308e-01 0.042
R-HSA-913531 Interferon Signaling 9.223419e-01 0.035
R-HSA-72312 rRNA processing 9.270746e-01 0.033
R-HSA-202733 Cell surface interactions at the vascular wall 9.307955e-01 0.031
R-HSA-5668914 Diseases of metabolism 9.468403e-01 0.024
R-HSA-211859 Biological oxidations 9.773434e-01 0.010
R-HSA-9709957 Sensory Perception 9.777377e-01 0.010
R-HSA-196854 Metabolism of vitamins and cofactors 9.818027e-01 0.008
R-HSA-8978868 Fatty acid metabolism 9.885732e-01 0.005
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 9.931321e-01 0.003
R-HSA-556833 Metabolism of lipids 9.999867e-01 0.000
R-HSA-1430728 Metabolism 1.000000e+00 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
GAKGAK 0.820 -0.041 1 0.716
TTKTTK 0.819 0.062 -2 0.775
PKRPKR 0.817 0.029 1 0.727
ALK4ALK4 0.817 0.156 -2 0.791
MST1MST1 0.817 0.031 1 0.711
BRAFBRAF 0.816 0.041 -4 0.742
ALK2ALK2 0.815 0.221 -2 0.781
TAK1TAK1 0.815 -0.021 1 0.728
MST2MST2 0.814 0.017 1 0.722
TNIKTNIK 0.814 0.034 3 0.872
ALPHAK3ALPHAK3 0.814 0.068 -1 0.713
EEF2KEEF2K 0.814 0.033 3 0.851
GCKGCK 0.813 0.024 1 0.733
MINKMINK 0.812 0.003 1 0.714
VRK2VRK2 0.809 -0.254 1 0.745
LRRK2LRRK2 0.809 -0.121 2 0.866
BMPR1BBMPR1B 0.809 0.219 1 0.767
TGFBR1TGFBR1 0.809 0.180 -2 0.772
CAMKK1CAMKK1 0.809 0.054 -2 0.758
BMPR2BMPR2 0.809 0.001 -2 0.806
NIKNIK 0.809 -0.012 -3 0.847
MEK1MEK1 0.808 -0.084 2 0.854
NEK1NEK1 0.808 -0.055 1 0.695
OSR1OSR1 0.807 -0.019 2 0.805
KHS1KHS1 0.806 0.024 1 0.725
CAMKK2CAMKK2 0.805 0.004 -2 0.746
TAO2TAO2 0.805 -0.066 2 0.861
KHS2KHS2 0.805 0.043 1 0.739
ASK1ASK1 0.805 -0.107 1 0.670
HGKHGK 0.805 -0.028 3 0.873
MEKK2MEKK2 0.805 -0.061 2 0.822
VRK1VRK1 0.804 -0.196 2 0.847
NEK5NEK5 0.804 -0.072 1 0.708
MYO3AMYO3A 0.804 -0.029 1 0.699
BIKEBIKE 0.804 -0.026 1 0.596
ACVR2BACVR2B 0.803 0.150 -2 0.792
LATS1LATS1 0.803 0.066 -3 0.829
NEK8NEK8 0.803 -0.042 2 0.840
HPK1HPK1 0.803 0.005 1 0.741
BMPR1ABMPR1A 0.803 0.220 1 0.750
ACVR2AACVR2A 0.803 0.143 -2 0.781
DLKDLK 0.803 -0.034 1 0.733
MEK5MEK5 0.802 -0.181 2 0.844
LKB1LKB1 0.802 -0.041 -3 0.785
PLK1PLK1 0.802 0.130 -2 0.792
MOSMOS 0.802 0.054 1 0.790
CAMK1BCAMK1B 0.801 0.034 -3 0.815
TAO3TAO3 0.801 -0.051 1 0.705
ZAKZAK 0.800 -0.034 1 0.680
PRPKPRPK 0.800 -0.016 -1 0.756
DAPK2DAPK2 0.800 -0.075 -3 0.818
MYO3BMYO3B 0.800 -0.052 2 0.823
ANKRD3ANKRD3 0.800 -0.075 1 0.747
CAMLCKCAMLCK 0.800 -0.037 -2 0.736
YSK4YSK4 0.799 -0.008 1 0.700
STLK3STLK3 0.799 -0.112 1 0.644
PDK1PDK1 0.799 -0.098 1 0.743
MST3MST3 0.798 -0.027 2 0.825
MAP3K15MAP3K15 0.798 -0.131 1 0.671
PASKPASK 0.798 -0.000 -3 0.806
MEKK3MEKK3 0.798 -0.040 1 0.704
NEK4NEK4 0.797 -0.061 1 0.693
GRK6GRK6 0.797 0.161 1 0.788
MEKK1MEKK1 0.795 -0.113 1 0.681
NEK11NEK11 0.795 -0.114 1 0.723
PLK3PLK3 0.794 0.170 2 0.870
YSK1YSK1 0.794 -0.085 2 0.805
MEK2MEK2 0.794 -0.166 2 0.818
COTCOT 0.794 0.214 2 0.895
PERKPERK 0.793 -0.027 -2 0.803
JNK2JNK2 0.793 0.048 1 0.539
LOKLOK 0.793 -0.037 -2 0.687
PBKPBK 0.792 -0.068 1 0.619
CAMK2GCAMK2G 0.792 0.117 2 0.879
NLKNLK 0.792 -0.002 1 0.723
RAF1RAF1 0.791 0.044 1 0.775
DAPK3DAPK3 0.791 -0.033 -3 0.758
JNK3JNK3 0.791 0.030 1 0.575
MEKK6MEKK6 0.791 -0.170 1 0.668
AAK1AAK1 0.791 -0.012 1 0.499
DMPK1DMPK1 0.791 -0.004 -3 0.711
SMMLCKSMMLCK 0.790 -0.056 -3 0.758
HRIHRI 0.790 -0.052 -2 0.799
GRK7GRK7 0.789 0.076 1 0.747
MLK2MLK2 0.789 -0.106 2 0.828
CDKL1CDKL1 0.788 -0.032 -3 0.743
ROCK2ROCK2 0.788 -0.007 -3 0.740
TSSK2TSSK2 0.788 0.042 -5 0.886
SKMLCKSKMLCK 0.787 -0.004 -2 0.702
PLK2PLK2 0.786 0.185 -3 0.843
TLK1TLK1 0.786 0.010 -2 0.762
CHK1CHK1 0.786 0.048 -3 0.806
PIM1PIM1 0.786 0.061 -3 0.742
DSTYKDSTYK 0.786 0.150 2 0.891
ATRATR 0.786 -0.088 1 0.710
CHAK2CHAK2 0.786 0.007 -1 0.782
SLKSLK 0.785 -0.041 -2 0.634
MLK1MLK1 0.785 -0.024 2 0.828
ERK5ERK5 0.785 0.045 1 0.698
PKN3PKN3 0.785 0.038 -3 0.764
PRP4PRP4 0.784 -0.027 -3 0.720
MLK4MLK4 0.783 0.016 2 0.776
GRK5GRK5 0.783 -0.038 -3 0.858
ICKICK 0.783 -0.064 -3 0.774
DCAMKL2DCAMKL2 0.783 0.040 -3 0.761
P38AP38A 0.782 -0.015 1 0.604
CLK3CLK3 0.782 0.127 1 0.739
TLK2TLK2 0.781 -0.053 1 0.674
P38BP38B 0.781 0.000 1 0.559
MPSK1MPSK1 0.781 -0.128 1 0.638
MLK3MLK3 0.781 0.027 2 0.781
DCAMKL1DCAMKL1 0.780 -0.012 -3 0.743
NEK9NEK9 0.780 -0.089 2 0.837
DAPK1DAPK1 0.780 -0.037 -3 0.733
TAO1TAO1 0.779 -0.100 1 0.639
PDHK4PDHK4 0.779 -0.120 1 0.770
PIM3PIM3 0.779 0.036 -3 0.797
DRAK1DRAK1 0.779 -0.001 1 0.740
ERK2ERK2 0.778 -0.005 1 0.590
CDC7CDC7 0.778 0.077 1 0.792
BUB1BUB1 0.778 0.036 -5 0.859
PKCDPKCD 0.778 0.006 2 0.824
GRK2GRK2 0.777 0.007 -2 0.632
MRCKAMRCKA 0.777 0.009 -3 0.716
MASTLMASTL 0.777 -0.198 -2 0.726
ROCK1ROCK1 0.776 -0.017 -3 0.709
IRAK4IRAK4 0.776 -0.094 1 0.681
PIM2PIM2 0.776 0.013 -3 0.689
PDHK1PDHK1 0.775 -0.104 1 0.755
AMPKA1AMPKA1 0.775 -0.045 -3 0.804
PKN2PKN2 0.775 0.010 -3 0.791
TGFBR2TGFBR2 0.775 0.043 -2 0.777
WNK4WNK4 0.775 -0.118 -2 0.716
CAMK2BCAMK2B 0.774 0.128 2 0.844
P70S6KBP70S6KB 0.774 0.004 -3 0.752
PINK1PINK1 0.774 -0.111 1 0.691
RIPK3RIPK3 0.773 -0.057 3 0.784
DNAPKDNAPK 0.772 0.026 1 0.650
ATMATM 0.772 0.020 1 0.670
WNK1WNK1 0.772 -0.045 -2 0.717
P38GP38G 0.772 0.002 1 0.477
HUNKHUNK 0.772 -0.066 2 0.855
HASPINHASPIN 0.771 -0.043 -1 0.627
NEK2NEK2 0.771 -0.102 2 0.814
RIPK1RIPK1 0.771 -0.169 1 0.719
TBK1TBK1 0.771 0.043 1 0.690
CDK5CDK5 0.770 0.007 1 0.586
IRE2IRE2 0.770 -0.011 2 0.787
MRCKBMRCKB 0.770 -0.012 -3 0.688
CHAK1CHAK1 0.770 -0.080 2 0.790
NUAK2NUAK2 0.770 -0.041 -3 0.783
CRIKCRIK 0.770 -0.016 -3 0.642
TSSK1TSSK1 0.769 -0.029 -3 0.812
P38DP38D 0.769 0.023 1 0.468
CAMK2DCAMK2D 0.769 0.010 -3 0.793
NEK7NEK7 0.769 -0.050 -3 0.798
PAK1PAK1 0.768 0.013 -2 0.660
CAMK1DCAMK1D 0.768 0.015 -3 0.633
MST4MST4 0.768 -0.009 2 0.826
TTBK2TTBK2 0.768 -0.012 2 0.825
NEK6NEK6 0.768 0.020 -2 0.784
GRK1GRK1 0.768 0.083 -2 0.681
JNK1JNK1 0.768 0.010 1 0.544
CDK1CDK1 0.768 0.018 1 0.561
MYLK4MYLK4 0.767 -0.027 -2 0.653
ULK2ULK2 0.767 -0.096 2 0.834
NEK3NEK3 0.767 -0.176 1 0.638
PAK2PAK2 0.766 -0.042 -2 0.656
CAMK4CAMK4 0.766 -0.029 -3 0.784
CDKL5CDKL5 0.765 -0.037 -3 0.725
MTORMTOR 0.765 -0.098 1 0.729
CDK2CDK2 0.765 0.009 1 0.641
HIPK1HIPK1 0.764 -0.030 1 0.618
GSK3BGSK3B 0.764 -0.056 4 0.315
SGK3SGK3 0.764 -0.018 -3 0.706
RSK2RSK2 0.764 0.030 -3 0.716
AMPKA2AMPKA2 0.764 -0.044 -3 0.772
CAMK2ACAMK2A 0.764 0.054 2 0.837
ERK7ERK7 0.764 -0.002 2 0.561
IKKEIKKE 0.763 0.038 1 0.690
IRE1IRE1 0.763 -0.081 1 0.676
WNK3WNK3 0.762 -0.147 1 0.713
MELKMELK 0.762 -0.043 -3 0.752
STK33STK33 0.762 -0.019 2 0.775
PKCHPKCH 0.762 -0.032 2 0.759
AKT2AKT2 0.762 -0.009 -3 0.627
GSK3AGSK3A 0.762 -0.037 4 0.332
IKKBIKKB 0.761 0.043 -2 0.709
ERK1ERK1 0.761 -0.021 1 0.543
GRK4GRK4 0.761 -0.016 -2 0.722
CDK14CDK14 0.761 -0.022 1 0.564
MARK4MARK4 0.761 -0.100 4 0.565
MOKMOK 0.761 -0.014 1 0.634
P90RSKP90RSK 0.760 -0.004 -3 0.712
CAMK1GCAMK1G 0.760 -0.012 -3 0.706
IRAK1IRAK1 0.759 -0.178 -1 0.668
CHK2CHK2 0.759 -0.028 -3 0.578
CLK4CLK4 0.759 -0.008 -3 0.715
PLK4PLK4 0.759 -0.044 2 0.735
CDK16CDK16 0.758 0.015 1 0.501
PAK3PAK3 0.758 -0.045 -2 0.672
MAPKAPK3MAPKAPK3 0.758 -0.009 -3 0.730
PKCZPKCZ 0.758 -0.074 2 0.804
SGK1SGK1 0.758 -0.010 -3 0.554
DYRK2DYRK2 0.758 -0.034 1 0.608
PKCAPKCA 0.757 -0.035 2 0.761
SMG1SMG1 0.757 -0.091 1 0.659
MAKMAK 0.757 -0.029 -2 0.599
CDK6CDK6 0.757 -0.023 1 0.534
RSK4RSK4 0.756 0.039 -3 0.682
PKCBPKCB 0.756 -0.016 2 0.763
AKT1AKT1 0.756 -0.003 -3 0.648
CDK4CDK4 0.756 -0.026 1 0.527
IKKAIKKA 0.756 0.054 -2 0.695
RIPK2RIPK2 0.755 -0.162 1 0.648
PKCGPKCG 0.755 -0.017 2 0.788
ULK1ULK1 0.755 -0.074 -3 0.775
PRKD3PRKD3 0.755 -0.005 -3 0.680
DYRK1ADYRK1A 0.754 -0.051 1 0.631
SSTKSSTK 0.754 -0.058 4 0.534
NDR1NDR1 0.754 -0.038 -3 0.797
SRPK3SRPK3 0.754 -0.011 -3 0.669
AURBAURB 0.753 -0.019 -2 0.549
SRPK1SRPK1 0.753 0.010 -3 0.686
AURAAURA 0.753 0.008 -2 0.521
CAMK1ACAMK1A 0.753 -0.008 -3 0.606
MNK1MNK1 0.752 -0.005 -2 0.674
CDK3CDK3 0.752 0.027 1 0.500
MSK1MSK1 0.752 -0.010 -3 0.704
GCN2GCN2 0.752 -0.069 2 0.821
PKCEPKCE 0.752 -0.010 2 0.761
MAPKAPK2MAPKAPK2 0.751 0.054 -3 0.698
QIKQIK 0.751 -0.121 -3 0.792
DYRK1BDYRK1B 0.751 -0.030 1 0.567
CDK17CDK17 0.751 -0.030 1 0.486
GRK3GRK3 0.751 0.002 -2 0.587
PKACGPKACG 0.750 -0.028 -2 0.630
HIPK3HIPK3 0.749 -0.076 1 0.609
PKCIPKCI 0.749 -0.049 2 0.771
RSK3RSK3 0.749 -0.018 -3 0.711
TTBK1TTBK1 0.749 0.006 2 0.781
PDHK3_TYRPDHK3_TYR 0.749 0.151 4 0.685
MARK2MARK2 0.748 -0.106 4 0.470
CK2A2CK2A2 0.748 0.107 1 0.666
PKCTPKCT 0.748 -0.053 2 0.768
NIM1NIM1 0.748 -0.107 3 0.811
PRKD2PRKD2 0.748 0.028 -3 0.711
PRKD1PRKD1 0.747 -0.008 -3 0.757
LATS2LATS2 0.747 -0.012 -5 0.773
MARK1MARK1 0.747 -0.092 4 0.523
DYRK3DYRK3 0.747 -0.044 1 0.617
CDK18CDK18 0.746 -0.029 1 0.520
MNK2MNK2 0.746 -0.025 -2 0.661
MSK2MSK2 0.746 -0.046 -3 0.697
CLK1CLK1 0.746 -0.006 -3 0.685
CDK8CDK8 0.746 -0.040 1 0.547
SBKSBK 0.746 -0.016 -3 0.512
YANK3YANK3 0.746 0.052 2 0.597
FAM20CFAM20C 0.746 0.179 2 0.736
HIPK4HIPK4 0.746 -0.075 1 0.679
P70S6KP70S6K 0.745 -0.030 -3 0.656
CDK13CDK13 0.745 -0.050 1 0.559
BCKDKBCKDK 0.743 -0.092 -1 0.719
PKG2PKG2 0.743 -0.041 -2 0.571
PHKG1PHKG1 0.743 -0.047 -3 0.794
NUAK1NUAK1 0.742 -0.069 -3 0.743
MARK3MARK3 0.742 -0.088 4 0.500
QSKQSK 0.742 -0.096 4 0.540
CDK10CDK10 0.742 -0.011 1 0.550
EPHA6EPHA6 0.742 0.125 -1 0.773
CLK2CLK2 0.742 0.057 -3 0.696
MAP2K6_TYRMAP2K6_TYR 0.741 0.047 -1 0.801
PKACBPKACB 0.741 -0.002 -2 0.569
DYRK4DYRK4 0.741 -0.016 1 0.540
AURCAURC 0.740 -0.008 -2 0.541
TESK1_TYRTESK1_TYR 0.740 -0.035 3 0.892
PDHK4_TYRPDHK4_TYR 0.740 0.036 2 0.890
CDK7CDK7 0.740 -0.065 1 0.570
CK2A1CK2A1 0.739 0.072 1 0.649
CDK12CDK12 0.739 -0.059 1 0.537
YANK2YANK2 0.739 0.031 2 0.610
BMPR2_TYRBMPR2_TYR 0.738 0.031 -1 0.768
NDR2NDR2 0.738 -0.046 -3 0.805
PKN1PKN1 0.738 -0.021 -3 0.664
CK1DCK1D 0.737 -0.007 -3 0.529
SIKSIK 0.737 -0.082 -3 0.740
CDK9CDK9 0.737 -0.072 1 0.568
SRPK2SRPK2 0.737 0.009 -3 0.619
HIPK2HIPK2 0.737 -0.032 1 0.528
PDHK1_TYRPDHK1_TYR 0.736 0.025 -1 0.813
AKT3AKT3 0.736 -0.008 -3 0.564
PINK1_TYRPINK1_TYR 0.736 -0.056 1 0.745
MAP2K4_TYRMAP2K4_TYR 0.736 -0.070 -1 0.781
SNRKSNRK 0.735 -0.139 2 0.763
EPHA4EPHA4 0.735 0.150 2 0.873
INSRRINSRR 0.735 0.094 3 0.772
EPHB4EPHB4 0.734 0.072 -1 0.757
MAP2K7_TYRMAP2K7_TYR 0.734 -0.163 2 0.889
RETRET 0.734 -0.007 1 0.710
CDK19CDK19 0.732 -0.038 1 0.514
PKACAPKACA 0.732 -0.014 -2 0.524
LIMK2_TYRLIMK2_TYR 0.732 -0.068 -3 0.847
BRSK1BRSK1 0.731 -0.063 -3 0.746
FERFER 0.731 0.060 1 0.769
TYK2TYK2 0.730 -0.026 1 0.708
CSF1RCSF1R 0.730 0.003 3 0.812
PHKG2PHKG2 0.730 -0.031 -3 0.750
CK1A2CK1A2 0.730 -0.018 -3 0.525
FGFR2FGFR2 0.730 0.039 3 0.808
ABL2ABL2 0.730 0.029 -1 0.741
FLT3FLT3 0.729 0.018 3 0.806
TYRO3TYRO3 0.729 -0.058 3 0.818
ROS1ROS1 0.729 -0.025 3 0.799
BRSK2BRSK2 0.729 -0.108 -3 0.772
CK1ECK1E 0.728 -0.013 -3 0.577
PKMYT1_TYRPKMYT1_TYR 0.728 -0.199 3 0.861
PAK6PAK6 0.728 -0.023 -2 0.621
DDR1DDR1 0.728 -0.076 4 0.595
JAK3JAK3 0.727 -0.011 1 0.692
TXKTXK 0.727 0.053 1 0.725
EPHB1EPHB1 0.727 0.053 1 0.750
MAPKAPK5MAPKAPK5 0.727 -0.100 -3 0.665
MST1RMST1R 0.726 -0.088 3 0.819
EPHB2EPHB2 0.726 0.090 -1 0.739
PDGFRBPDGFRB 0.726 -0.027 3 0.825
EPHB3EPHB3 0.726 0.063 -1 0.745
JAK2JAK2 0.725 -0.046 1 0.699
KITKIT 0.725 -0.003 3 0.813
SRMSSRMS 0.725 0.058 1 0.766
FGRFGR 0.725 -0.020 1 0.721
LIMK1_TYRLIMK1_TYR 0.725 -0.192 2 0.879
KISKIS 0.725 0.032 1 0.586
PRKXPRKX 0.724 0.022 -3 0.635
YES1YES1 0.724 -0.022 -1 0.704
TEKTEK 0.724 -0.014 3 0.756
FGFR3FGFR3 0.723 0.045 3 0.782
KDRKDR 0.723 -0.020 3 0.779
ABL1ABL1 0.723 -0.020 -1 0.722
ITKITK 0.722 0.006 -1 0.685
MERTKMERTK 0.722 0.016 3 0.783
FGFR1FGFR1 0.721 -0.034 3 0.781
EPHA7EPHA7 0.721 0.070 2 0.888
FLT1FLT1 0.721 0.022 -1 0.795
EPHA5EPHA5 0.720 0.108 2 0.870
ERBB2ERBB2 0.720 0.004 1 0.710
FLT4FLT4 0.720 0.008 3 0.770
NTRK1NTRK1 0.719 0.001 -1 0.752
HCKHCK 0.719 -0.034 -1 0.694
EGFREGFR 0.719 0.074 1 0.632
FRKFRK 0.719 0.041 -1 0.748
EPHA3EPHA3 0.719 0.032 2 0.866
AXLAXL 0.718 -0.048 3 0.792
LCKLCK 0.718 -0.013 -1 0.695
LTKLTK 0.718 -0.013 3 0.760
PDGFRAPDGFRA 0.718 -0.086 3 0.820
BTKBTK 0.718 -0.052 -1 0.659
TNK2TNK2 0.716 -0.086 3 0.762
ALKALK 0.716 -0.046 3 0.740
INSRINSR 0.715 -0.025 3 0.747
BMXBMX 0.715 -0.013 -1 0.616
EPHA8EPHA8 0.715 0.068 -1 0.724
BLKBLK 0.715 0.011 -1 0.708
NEK10_TYRNEK10_TYR 0.715 -0.064 1 0.625
METMET 0.714 -0.068 3 0.792
SYKSYK 0.714 0.094 -1 0.713
TECTEC 0.714 -0.041 -1 0.614
PAK5PAK5 0.713 -0.071 -2 0.552
MATKMATK 0.713 -0.010 -1 0.701
PTK2PTK2 0.713 0.081 -1 0.680
TNK1TNK1 0.712 -0.123 3 0.796
WEE1_TYRWEE1_TYR 0.711 -0.078 -1 0.660
FYNFYN 0.711 0.013 -1 0.647
NTRK2NTRK2 0.711 -0.079 3 0.762
FGFR4FGFR4 0.710 0.044 -1 0.714
EPHA1EPHA1 0.710 -0.057 3 0.771
JAK1JAK1 0.710 -0.056 1 0.668
TNNI3K_TYRTNNI3K_TYR 0.710 -0.102 1 0.653
NTRK3NTRK3 0.710 -0.043 -1 0.718
PTK2BPTK2B 0.708 -0.006 -1 0.644
PTK6PTK6 0.708 -0.130 -1 0.636
CSKCSK 0.708 0.010 2 0.885
EPHA2EPHA2 0.708 0.069 -1 0.710
DDR2DDR2 0.707 -0.042 3 0.760
IGF1RIGF1R 0.707 0.014 3 0.685
LYNLYN 0.705 -0.046 3 0.733
ERBB4ERBB4 0.704 0.041 1 0.663
MUSKMUSK 0.702 -0.042 1 0.623
PAK4PAK4 0.702 -0.072 -2 0.548
SRCSRC 0.699 -0.056 -1 0.646
PKG1PKG1 0.696 -0.092 -2 0.505
CK1G1CK1G1 0.696 -0.036 -3 0.595
CK1G3CK1G3 0.694 -0.019 -3 0.406
FESFES 0.682 -0.077 -1 0.583
ZAP70ZAP70 0.682 -0.031 -1 0.624
CK1G2CK1G2 0.677 -0.027 -3 0.506
CK1ACK1A 0.668 -0.025 -3 0.452