Motif 1058 (n=222)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| E7EQ34 | None | T108 | ochoa | Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) | Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. {ECO:0000256|ARBA:ARBA00037078, ECO:0000256|PIRNR:PIRNR028865}. |
| H0YHG0 | None | T378 | ochoa | DnaJ homolog subfamily C member 14 (Nuclear protein Hcc-1) (SAP domain-containing ribonucleoprotein) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. {ECO:0000256|ARBA:ARBA00054093}.; FUNCTION: Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface. {ECO:0000256|ARBA:ARBA00055510}. |
| L7N2F9 | None | T79 | ochoa | V-SNARE coiled-coil homology domain-containing protein | None |
| O00567 | NOP56 | T529 | ochoa | Nucleolar protein 56 (Nucleolar protein 5A) | Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:12777385, PubMed:39570315). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}. |
| O14653 | GOSR2 | T108 | ochoa | Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) | Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. {ECO:0000269|PubMed:9349823}. |
| O14686 | KMT2D | T1681 | ochoa | Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:25561738}. |
| O14921 | RGS13 | T41 | psp | Regulator of G-protein signaling 13 (RGS13) | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity). {ECO:0000250}. |
| O14978 | ZNF263 | T149 | ochoa | Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12) | Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). {ECO:0000269|PubMed:32051553, ECO:0000269|PubMed:32277030}. |
| O14980 | XPO1 | T1030 | ochoa | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. {ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:20921223, ECO:0000269|PubMed:9311922, ECO:0000269|PubMed:9323133}.; FUNCTION: (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. {ECO:0000269|PubMed:14612415, ECO:0000269|PubMed:9837918}. |
| O15061 | SYNM | T1388 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15355 | PPM1G | T199 | ochoa | Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) | None |
| O15417 | TNRC18 | T2534 | ochoa | Trinucleotide repeat-containing gene 18 protein (Long CAG trinucleotide repeat-containing gene 79 protein) | None |
| O43395 | PRPF3 | T494 | psp | U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000305|PubMed:20595234}. |
| O43815 | STRN | T263 | ochoa | Striatin | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000305|PubMed:26876214}. |
| O60293 | ZFC3H1 | T278 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O60336 | MAPKBP1 | T796 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O95613 | PCNT | T186 | ochoa | Pericentrin (Kendrin) (Pericentrin-B) | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. {ECO:0000269|PubMed:10823944, ECO:0000269|PubMed:11171385, ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:20599736, ECO:0000269|PubMed:30420784}. |
| P05455 | SSB | T379 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P10451 | SPP1 | T237 | ochoa|psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P11055 | MYH3 | T1480 | ochoa | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | Muscle contraction. |
| P12882 | MYH1 | T95 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12882 | MYH1 | T1483 | ochoa | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | Required for normal hearing. It plays a role in cochlear amplification of auditory stimuli, likely through the positive regulation of prestin (SLC26A5) activity and outer hair cell (OHC) electromotility. {ECO:0000250|UniProtKB:Q5SX40}. |
| P12883 | MYH7 | T1127 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1282 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1351 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1479 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P12883 | MYH7 | T1605 | ochoa | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}. |
| P13533 | MYH6 | T1129 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | T1353 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | T1481 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13533 | MYH6 | T1607 | ochoa | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | Muscle contraction. |
| P13535 | MYH8 | T1482 | ochoa | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | Muscle contraction. |
| P13639 | EEF2 | T59 | ochoa|psp | Elongation factor 2 (EF-2) (EC 3.6.5.-) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:26593721). During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:26593721). Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721). {ECO:0000269|PubMed:26593721}. |
| P14625 | HSP90B1 | T504 | ochoa | Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog) | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:11584270, ECO:0000269|PubMed:23572575, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:39509507}. |
| P19237 | TNNI1 | T91 | ochoa | Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform) | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| P20618 | PSMB1 | T65 | ochoa | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) | Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. |
| P22626 | HNRNPA2B1 | T140 | ochoa | Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}. |
| P24001 | IL32 | T116 | ochoa | Interleukin-32 (IL-32) (Natural killer cells protein 4) (Tumor necrosis factor alpha-inducing factor) | Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. {ECO:0000269|PubMed:15664165}. |
| P25685 | DNAJB1 | T180 | ochoa | DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) | Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:9499401}. |
| P30307 | CDC25C | T236 | psp | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). {ECO:0000269|PubMed:8119945}. |
| P33981 | TTK | T360 | psp | Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}. |
| P36405 | ARL3 | T46 | ochoa | ADP-ribosylation factor-like protein 3 | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). {ECO:0000250|UniProtKB:Q9WUL7, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}. |
| P39880 | CUX1 | T1157 | ochoa | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110] | Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}. |
| P46013 | MKI67 | T1111 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1233 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1355 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1476 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1719 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1841 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1963 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2085 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2203 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2325 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2598 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2927 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | T1152 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P46821 | MAP1B | T1896 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49736 | MCM2 | T106 | ochoa | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677). {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:8175912}. |
| P49768 | PSEN1 | T74 | psp | Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15004326, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:16959576, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:20460383, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:25394380, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:28269784, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000269|PubMed:9738936}. |
| P49792 | RANBP2 | T2610 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50579 | METAP2 | T30 | ochoa | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| P51153 | RAB13 | T36 | ochoa | Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}. |
| P51153 | RAB13 | T74 | ochoa | Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB13 is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367, ECO:0000269|PubMed:20008558, ECO:0000269|PubMed:35343654}. |
| P51587 | BRCA2 | T2031 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P60709 | ACTB | T106 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62805 | H4C1 | T81 | ochoa | Histone H4 | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| P62913 | RPL11 | T34 | ochoa | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (CLL-associated antigen KW-12) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:19191325, PubMed:32669547). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:19191325, PubMed:32669547). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:19191325, PubMed:32669547). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:19191325, PubMed:32669547). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity). {ECO:0000250|UniProtKB:Q9CXW4, ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:19191325, ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:32669547}. |
| P63027 | VAMP2 | T79 | ochoa | Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) | Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63044, ECO:0000250|UniProtKB:P63045, ECO:0000269|PubMed:30929742}. |
| P63261 | ACTG1 | T106 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P82979 | SARNP | T65 | ochoa | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15338056, PubMed:17196963, PubMed:20844015). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15338056, PubMed:17196963, PubMed:20844015). Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). {ECO:0000269|PubMed:15338056, ECO:0000269|PubMed:17196963, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:37578863}. |
| P84157 | MXRA7 | Y143 | ochoa | Matrix-remodeling-associated protein 7 | None |
| Q00341 | HDLBP | T626 | ochoa | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| Q00688 | FKBP3 | T98 | ochoa | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q01118 | SCN7A | T794 | ochoa | Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) | Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303). In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (PubMed:26537257). {ECO:0000250|UniProtKB:B1AYL1, ECO:0000269|PubMed:26537257, ECO:0000269|PubMed:35301303}. |
| Q01826 | SATB1 | T188 | psp | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q02952 | AKAP12 | T1039 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q05519 | SRSF11 | T447 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q06323 | PSME1 | T25 | ochoa | Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
| Q09666 | AHNAK | T126 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12851 | MAP4K2 | T306 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q12906 | ILF3 | T486 | ochoa | Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80) | RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:28625552, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}. |
| Q13510 | ASAH1 | T271 | ochoa | Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (Glycosylceramide deacylase) (EC 3.5.1.109) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] | Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:11451951, PubMed:15655246, PubMed:26898341, PubMed:36752535, PubMed:7744740, PubMed:7852294). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:10610716). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (PubMed:15655246, PubMed:7744740). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:12764132, PubMed:12815059). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (PubMed:12764132). Also has an N-acylethanolamine hydrolase activity (PubMed:15655246). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (PubMed:17713573). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (PubMed:22261821). {ECO:0000250|UniProtKB:Q9WV54, ECO:0000269|PubMed:10610716, ECO:0000269|PubMed:11451951, ECO:0000269|PubMed:12764132, ECO:0000269|PubMed:12815059, ECO:0000269|PubMed:15655246, ECO:0000269|PubMed:17713573, ECO:0000269|PubMed:22261821, ECO:0000269|PubMed:26898341, ECO:0000269|PubMed:36752535, ECO:0000269|PubMed:7744740, ECO:0000269|PubMed:7852294, ECO:0000303|PubMed:10610716}.; FUNCTION: [Isoform 2]: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity. {ECO:0000305|PubMed:22927646}. |
| Q13596 | SNX1 | T48 | ochoa | Sorting nexin-1 | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
| Q13621 | SLC12A1 | T100 | psp | Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (BSC1) (Kidney-specific Na-K-Cl symporter) (Na-K-2Cl cotransporter 2) (NKCC2) | Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). Electrically silent transporter system (By similarity). {ECO:0000250|UniProtKB:P55014, ECO:0000250|UniProtKB:P55016, ECO:0000269|PubMed:21321328}. |
| Q13838 | DDX39B | T20 | ochoa | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:33191911, ECO:0000269|PubMed:37578863, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14126 | DSG2 | T791 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14162 | SCARF1 | T689 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q14457 | BECN1 | T388 | psp | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] | Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:25484083, PubMed:28445460, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). May play a role in antiviral host defense. {ECO:0000269|PubMed:18570871, ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:23974797, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:25484083, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:37776275, ECO:0000269|PubMed:9765397}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors. {ECO:0000269|PubMed:21364619, ECO:0000269|PubMed:26263979}.; FUNCTION: (Microbial infection) Protects against infection by a neurovirulent strain of Sindbis virus. {ECO:0000269|PubMed:9765397}. |
| Q14644 | RASA3 | T805 | ochoa | Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| Q14653 | IRF3 | T207 | psp | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14690 | PDCD11 | T37 | ochoa | Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) | Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA. {ECO:0000269|PubMed:17654514}.; FUNCTION: Involved in the biogenesis of rRNA. {ECO:0000250}. |
| Q14966 | ZNF638 | T1155 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15019 | SEPTIN2 | T228 | ochoa | Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5) | Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269|PubMed:15774761, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18209106, ECO:0000269|PubMed:19145258, ECO:0000305|PubMed:25588830}. |
| Q15029 | EFTUD2 | T90 | ochoa | 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) | Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:25092792, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:25092792, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154, ECO:0000305|PubMed:33509932}. |
| Q15121 | PEA15 | T97 | ochoa | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED) | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269|PubMed:10442631, ECO:0000269|PubMed:9670003}. |
| Q15831 | STK11 | T363 | psp | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:11430832, ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379, ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.; FUNCTION: [Isoform 2]: Has a role in spermiogenesis. {ECO:0000250}. |
| Q15836 | VAMP3 | T62 | ochoa | Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3) | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}. |
| Q16204 | CCDC6 | T115 | ochoa | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | None |
| Q32MZ4 | LRRFIP1 | T614 | ochoa | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein) | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:10364563, ECO:0000269|PubMed:14522076, ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123, ECO:0000269|PubMed:9705290}. |
| Q4G0N4 | NADK2 | T357 | psp | NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial) | Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}. |
| Q5C9Z4 | NOM1 | T287 | ochoa | Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) | Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}. |
| Q5JSP0 | FGD3 | T139 | ochoa | FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5) | Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q5MJ10 | SPANXN2 | T44 | ochoa | Sperm protein associated with the nucleus on the X chromosome N2 (Nuclear-associated protein SPAN-Xn2) (SPANX-N2) (SPANX family member N2) | None |
| Q5T0W9 | FAM83B | T725 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T200 | ZC3H13 | T984 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5VZ89 | DENND4C | T1216 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q5ZPR3 | CD276 | T515 | ochoa | CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}. |
| Q676U5 | ATG16L1 | T247 | ochoa | Autophagy-related protein 16-1 (APG16-like 1) | Plays an essential role in both canonical and non-canonical autophagy: interacts with ATG12-ATG5 to mediate the lipidation to ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAPL1, GABARAPL2 and GABARAP) (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576, PubMed:29317426, PubMed:30778222, PubMed:33909989). Acts as a molecular hub, coordinating autophagy pathways via distinct domains that support either canonical or non-canonical signaling (PubMed:29317426, PubMed:30778222). During canonical autophagy, interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to ATG8 proteins, to produce a membrane-bound activated form of ATG8 (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:23376921, PubMed:23392225, PubMed:24553140, PubMed:24954904, PubMed:27273576). As part of the ATG8 conjugation system with ATG5 and ATG12, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, probably by catalyzing conjugation of phosphatidylserine (PS) to ATG8 (PubMed:33909989). Non-canonical autophagy plays a key role in epithelial cells to limit lethal infection by influenza A (IAV) virus (By similarity). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:22749352, PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes an autophagy-dependent antibacterial pathway together with NOD1 or NOD2 (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966). {ECO:0000250|UniProtKB:Q8C0J2, ECO:0000269|PubMed:18849966, ECO:0000269|PubMed:20637199, ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:23392225, ECO:0000269|PubMed:24238340, ECO:0000269|PubMed:24553140, ECO:0000269|PubMed:24954904, ECO:0000269|PubMed:25645662, ECO:0000269|PubMed:27273576, ECO:0000269|PubMed:29317426, ECO:0000269|PubMed:30778222, ECO:0000269|PubMed:33909989}. |
| Q69YH5 | CDCA2 | T412 | ochoa|psp | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6JBY9 | RCSD1 | T336 | ochoa | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}. |
| Q6NUK4 | REEP3 | T216 | ochoa | Receptor expression-enhancing protein 3 | Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. {ECO:0000269|PubMed:23911198}. |
| Q6P1N0 | CC2D1A | T120 | ochoa | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. {ECO:0000250, ECO:0000269|PubMed:20171170}. |
| Q6ZV65 | FAM47E | T158 | ochoa | Protein FAM47E | Promotes histone methylation by localizing the arginine methyltransferase PRMT5 to chromatin. {ECO:0000269|PubMed:33376131}. |
| Q76FK4 | NOL8 | T381 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q76FK4 | NOL8 | T1045 | ochoa | Nucleolar protein 8 (Nucleolar protein Nop132) | Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. |
| Q7L5L3 | GDPD3 | T175 | psp | Lysophospholipase D GDPD3 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 7) (Glycerophosphodiester phosphodiesterase domain-containing protein 3) | Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N-acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. {ECO:0000250|UniProtKB:Q99LY2, ECO:0000269|PubMed:27637550}. |
| Q86V48 | LUZP1 | T249 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86VM9 | ZC3H18 | T162 | ochoa | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | None |
| Q8IVH8 | MAP4K3 | T458 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| Q8N163 | CCAR2 | T897 | ochoa|psp | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N594 | MPND | T437 | ochoa | MPN domain-containing protein (EC 3.4.-.-) | Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (PubMed:30982744). Binds only double strand DNA (dsDNA) in a sequence-independent manner (By similarity). {ECO:0000250|UniProtKB:Q3TV65, ECO:0000250|UniProtKB:Q5VVJ2, ECO:0000269|PubMed:30982744}. |
| Q8N5C6 | SRBD1 | T154 | ochoa | S1 RNA-binding domain-containing protein 1 | None |
| Q8N680 | ZBTB2 | T494 | ochoa | Zinc finger and BTB domain-containing protein 2 | May be involved in transcriptional regulation. |
| Q8NDI1 | EHBP1 | T331 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NFC6 | BOD1L1 | T2478 | ochoa | Biorientation of chromosomes in cell division protein 1-like 1 | Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705, PubMed:29937342). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705, ECO:0000269|PubMed:29937342}. |
| Q8NG31 | KNL1 | T1824 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TED0 | UTP15 | T493 | ochoa | U3 small nucleolar RNA-associated protein 15 homolog | Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17699751, ECO:0000269|PubMed:34516797}. |
| Q8WXD2 | SCG3 | T366 | ochoa | Secretogranin-3 (Secretogranin III) (SgIII) | Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827). {ECO:0000250|UniProtKB:P47868, ECO:0000269|PubMed:19357184, ECO:0000269|PubMed:29154827}. |
| Q92766 | RREB1 | T1471 | ochoa | Ras-responsive element-binding protein 1 (RREB-1) (Finger protein in nuclear bodies) (Raf-responsive zinc finger protein LZ321) (Zinc finger motif enhancer-binding protein 1) (Zep-1) | Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445). {ECO:0000250|UniProtKB:Q3UH06, ECO:0000269|PubMed:10390538, ECO:0000269|PubMed:12482979, ECO:0000269|PubMed:15067362, ECO:0000269|PubMed:17550981, ECO:0000269|PubMed:8816445, ECO:0000269|PubMed:9305772}. |
| Q92785 | DPF2 | T176 | ochoa|psp | Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem) | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). {ECO:0000250|UniProtKB:Q61103, ECO:0000269|PubMed:20460684, ECO:0000269|PubMed:27775714, ECO:0000269|PubMed:28533407}. |
| Q96A32 | MYL11 | T35 | ochoa | Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform) | Myosin regulatory subunit that plays an essential role to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). {ECO:0000250|UniProtKB:O93409}. |
| Q96BK5 | PINX1 | T172 | ochoa | PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) | Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}. |
| Q96GN5 | CDCA7L | T81 | ochoa | Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2) | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}. |
| Q96GX5 | MASTL | T611 | ochoa | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}. |
| Q99501 | GAS2L1 | T220 | ochoa | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | Involved in the cross-linking of microtubules and microfilaments (PubMed:12584248, PubMed:24706950). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (PubMed:24706950). {ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950}. |
| Q99590 | SCAF11 | T415 | ochoa | Protein SCAF11 (CTD-associated SR protein 11) (Renal carcinoma antigen NY-REN-40) (SC35-interacting protein 1) (SR-related and CTD-associated factor 11) (SRSF2-interacting protein) (Serine/arginine-rich splicing factor 2-interacting protein) (Splicing factor, arginine/serine-rich 2-interacting protein) (Splicing regulatory protein 129) (SRrp129) | Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. |
| Q9BST9 | RTKN | T433 | ochoa | Rhotekin | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:15480428, ECO:0000269|PubMed:16007136}. |
| Q9H2G2 | SLK | T327 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2G2 | SLK | T367 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9H2G2 | SLK | T569 | ochoa | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Q9NP64 | ZCCHC17 | T132 | ochoa | Zinc finger CCHC domain-containing protein 17 (Nucleolar protein of 40 kDa) (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein) | None |
| Q9NP97 | DYNLRB1 | T40 | ochoa | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. {ECO:0000305|PubMed:36071160}. |
| Q9NPQ8 | RIC8A | T443 | ochoa | Chaperone Ric-8A (Synembryn-A) | Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}. |
| Q9NQG1 | MANBAL | T63 | ochoa | Protein MANBAL | None |
| Q9NVI1 | FANCI | T1124 | ochoa | Fanconi anemia group I protein (Protein FACI) | Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites (PubMed:17412408, PubMed:17460694, PubMed:17452773, PubMed:19111657, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789). {ECO:0000250|UniProtKB:B0I564, ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17452773, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19111657, ECO:0000269|PubMed:19589784, ECO:0000269|PubMed:25862789, ECO:0000269|PubMed:36385258}. |
| Q9NVP1 | DDX18 | T47 | ochoa | ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) | ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (PubMed:35858569). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity). {ECO:0000250|UniProtKB:Q8K363, ECO:0000269|PubMed:35858569}. |
| Q9NWH9 | SLTM | T69 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NWQ8 | PAG1 | T183 | ochoa | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}. |
| Q9NYF8 | BCLAF1 | T405 | ochoa | Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) | Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}. |
| Q9P227 | ARHGAP23 | T1107 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9UGP4 | LIMD1 | T175 | ochoa | LIM domain-containing protein 1 | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. |
| Q9UGP8 | SEC63 | T463 | ochoa | Translocation protein SEC63 homolog (DnaJ homolog subfamily C member 23) | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Q9UKL0 | RCOR1 | T449 | ochoa | REST corepressor 1 (Protein CoREST) | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}. |
| Q9UKN1 | MUC12 | T5424 | ochoa | Mucin-12 (MUC-12) (Mucin-11) (MUC-11) | Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}. |
| Q9UKX2 | MYH2 | T51 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T95 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX2 | MYH2 | T1485 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UKX3 | MYH13 | T95 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UKX3 | MYH13 | T1483 | ochoa | Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin) | Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269|PubMed:23908353}. |
| Q9UKX7 | NUP50 | T246 | ochoa | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) | Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}. |
| Q9ULF5 | SLC39A10 | T580 | ochoa | Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) | Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250|UniProtKB:Q6P5F6, ECO:0000269|PubMed:17359283, ECO:0000269|PubMed:23186163, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30520657, ECO:0000269|PubMed:32797246}. |
| Q9ULI0 | ATAD2B | T1322 | ochoa | ATPase family AAA domain-containing protein 2B | None |
| Q9UMZ2 | SYNRG | T767 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UNQ0 | ABCG2 | T362 | psp | Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562, PubMed:36749388). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response. {ECO:0000250|UniProtKB:Q7TMS5, ECO:0000269|PubMed:11306452, ECO:0000269|PubMed:12477054, ECO:0000269|PubMed:12682043, ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:15670731, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:19506252, ECO:0000269|PubMed:20110355, ECO:0000269|PubMed:20368174, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181, ECO:0000269|PubMed:28554189, ECO:0000269|PubMed:30405239, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042, ECO:0000269|PubMed:38181789, ECO:0000305|PubMed:12958161}. |
| Q9UP95 | SLC12A4 | T983 | ochoa | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: No transporter activity. {ECO:0000269|PubMed:11551954}. |
| Q9UPN9 | TRIM33 | T1102 | ochoa | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. |
| Q9UPT8 | ZC3H4 | T72 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9UPV0 | CEP164 | T1209 | ochoa | Centrosomal protein of 164 kDa (Cep164) | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}. |
| Q9UQ80 | PA2G4 | T366 | ochoa|psp | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| Q9Y243 | AKT3 | T443 | ochoa | RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) | AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}. |
| Q9Y490 | TLN1 | T142 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y520 | PRRC2C | T159 | ochoa | Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) | Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}. |
| Q9Y623 | MYH4 | T95 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| Q9Y623 | MYH4 | T1483 | ochoa | Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal) | Muscle contraction. |
| P31327 | CPS1 | T903 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P62424 | RPL7A | T93 | Sugiyama | Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (PLA-X polypeptide) (Surfeit locus protein 3) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P00558 | PGK1 | T376 | Sugiyama | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P51858 | HDGF | T94 | Sugiyama | Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2) | [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). {ECO:0000269|PubMed:11751870, ECO:0000269|PubMed:15491618, ECO:0000269|PubMed:17974029, ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.; FUNCTION: [Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}. |
| P61254 | RPL26 | T94 | Sugiyama | Large ribosomal subunit protein uL24 (60S ribosomal protein L26) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:26100019, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:26100019, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:26100019}. |
| Q02878 | RPL6 | T235 | Sugiyama | Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}.; FUNCTION: (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). {ECO:0000269|PubMed:8457378}. |
| Q9H2U1 | DHX36 | T179 | Sugiyama | ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein) | Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:14731398, PubMed:18279852, PubMed:21993297, PubMed:22238380, PubMed:25579584). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (PubMed:16150737, PubMed:18842585, PubMed:20472641, PubMed:21586581, PubMed:24369427, PubMed:26195789). Plays a role in genomic integrity (PubMed:22238380). Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (PubMed:20472641, PubMed:21149580, PubMed:21846770, PubMed:22238380, PubMed:24151078, PubMed:25579584). Plays a role in transcriptional regulation (PubMed:21586581, PubMed:21993297). Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (PubMed:21993297). Plays a role in post-transcriptional regulation (PubMed:27940037). Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (PubMed:27940037). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability (PubMed:24369427, PubMed:26489465). Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression (PubMed:24369427). Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively (PubMed:26489465). Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation (PubMed:14731398, PubMed:18279852). Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (PubMed:14731398). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). {ECO:0000250|UniProtKB:D4A2Z8, ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q8VHK9, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18279852, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:18854321, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24151078, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:25579584, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26489465, ECO:0000269|PubMed:27940037}. |
| Q9UNX3 | RPL26L1 | T94 | Sugiyama | Ribosomal protein uL24-like (60S ribosomal protein L26-like 1) (Large ribosomal subunit protein uL24-like 1) | None |
| Q99848 | EBNA1BP2 | T182 | EPSD|PSP | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | Required for the processing of the 27S pre-rRNA. {ECO:0000250}. |
| P23921 | RRM1 | T555 | Sugiyama | Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
| P62753 | RPS6 | Y156 | Sugiyama | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| P13987 | CD59 | T85 | Sugiyama | CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59) | Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260). {ECO:0000269|PubMed:11882685, ECO:0000269|PubMed:1698710, ECO:0000269|PubMed:2475111, ECO:0000269|PubMed:2475570, ECO:0000269|PubMed:2606909, ECO:0000269|PubMed:36797260, ECO:0000269|PubMed:9053451}.; FUNCTION: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes. {ECO:0000269|PubMed:8670172}. |
| O75116 | ROCK2 | T489 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| Q562R1 | ACTBL2 | T107 | Sugiyama | Beta-actin-like protein 2 (Kappa-actin) | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000250}. |
| Q86UE4 | MTDH | T477 | Sugiyama | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| O43314 | PPIP5K2 | T251 | Sugiyama | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O95336 | PGLS | T91 | Sugiyama | 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) | Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. {ECO:0000269|PubMed:10518023}. |
| Q6PFW1 | PPIP5K1 | T262 | Sugiyama | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| P25098 | GRK2 | T493 | Sugiyama | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). {ECO:0000250|UniProtKB:P21146, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19715378, ECO:0000269|PubMed:30284927}. |
| P35626 | GRK3 | T493 | Sugiyama | G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2) | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. {ECO:0000250|UniProtKB:P26819}. |
| Q13451 | FKBP5 | T46 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731). {ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:26101251, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28363942, ECO:0000269|PubMed:31434731}. |
| P00505 | GOT2 | T403 | Sugiyama | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:31422819, ECO:0000269|PubMed:9537447}. |
| Q06830 | PRDX1 | T166 | Sugiyama | Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}. |
| Q96G46 | DUS3L | T57 | Sugiyama | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) | Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860). {ECO:0000269|PubMed:34556860}. |
| P06733 | ENO1 | T323 | Sugiyama | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| Q9UQ80 | PA2G4 | T60 | Sugiyama | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) | May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}. |
| P35579 | MYH9 | T90 | Sugiyama | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000269|PubMed:20944748, ECO:0000269|PubMed:39048823}. |
| P35580 | MYH10 | T94 | Sugiyama | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. {ECO:0000269|PubMed:20052411, ECO:0000269|PubMed:20603131}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 envelope glycoprotein B. {ECO:0000305|PubMed:25428876, ECO:0000305|PubMed:39048823}. |
| P13667 | PDIA4 | T503 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P61758 | VBP1 | T171 | Sugiyama | Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}. |
| Q9Y3Z3 | SAMHD1 | T365 | Sugiyama | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1) | Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23364794, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:25038827, PubMed:26101257, PubMed:26294762, PubMed:26431200, PubMed:28229507). Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:24217394, PubMed:29610582). Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451). Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23601106, PubMed:23602554, PubMed:29610582, PubMed:29670289). Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289). Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289). Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity). {ECO:0000250|UniProtKB:Q60710, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:21613998, ECO:0000269|PubMed:21720370, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:23364794, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:23858451, ECO:0000269|PubMed:24035396, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:24336198, ECO:0000269|PubMed:25038827, ECO:0000269|PubMed:26101257, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:27477283, ECO:0000269|PubMed:28229507, ECO:0000269|PubMed:28834754, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289}. |
| Q15303 | ERBB4 | T1211 | Sugiyama | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q13642 | FHL1 | T152 | Sugiyama | Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1) | May have an involvement in muscle development or hypertrophy. |
| Q5T3I0 | GPATCH4 | T356 | Sugiyama | G patch domain-containing protein 4 | None |
| O75116 | ROCK2 | T878 | Sugiyama | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}. |
| P61586 | RHOA | T175 | Sugiyama | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle (PubMed:23871831). Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:31570889, PubMed:8910519, PubMed:9121475). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:12900402, PubMed:16236794). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:19403695, PubMed:9635436). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (PubMed:31888991). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). When activated by DAAM1 may signal centrosome maturation and chromosomal segregation during cell division. May also be involved in contractile ring formation during cytokinesis. {ECO:0000250|UniProtKB:P61589, ECO:0000250|UniProtKB:Q9QUI0, ECO:0000269|PubMed:12900402, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19403695, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:31570889, ECO:0000269|PubMed:31888991, ECO:0000269|PubMed:8910519, ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}.; FUNCTION: (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague. {ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}. |
| P61163 | ACTR1A | T111 | Sugiyama | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:F2Z5G5}. |
| Q8NG66 | NEK11 | T73 | Sugiyama | Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}. |
| Q9NYU2 | UGGT1 | T808 | Sugiyama | UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}. |
| A6NMY6 | ANXA2P2 | T136 | Sugiyama | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| P07355 | ANXA2 | T136 | Sugiyama | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| Q00688 | FKBP3 | T103 | Sugiyama | Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase) | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. |
| Q14203 | DCTN1 | T714 | Sugiyama | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q9P2K8 | EIF2AK4 | T462 | Sugiyama | eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). {ECO:0000250|UniProtKB:P15442, ECO:0000250|UniProtKB:Q9QZ05, ECO:0000269|PubMed:25329545, ECO:0000269|PubMed:26102367, ECO:0000269|PubMed:32610081}.; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610). {ECO:0000269|PubMed:24310610}. |
| P30101 | PDIA3 | T72 | Sugiyama | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| P27797 | CALR | T173 | Sugiyama | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}. |
| Q02952 | AKAP12 | T577 | Sugiyama | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q9H2K8 | TAOK3 | T602 | Sugiyama | Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8953897 | Cellular responses to stimuli | 3.212003e-07 | 6.493 |
| R-HSA-2262752 | Cellular responses to stress | 1.485869e-07 | 6.828 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 3.999262e-07 | 6.398 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 9.227311e-06 | 5.035 |
| R-HSA-381070 | IRE1alpha activates chaperones | 1.490674e-05 | 4.827 |
| R-HSA-156902 | Peptide chain elongation | 7.598588e-05 | 4.119 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 8.254525e-05 | 4.083 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 6.528948e-05 | 4.185 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.070913e-04 | 3.970 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 1.054007e-04 | 3.977 |
| R-HSA-168255 | Influenza Infection | 1.235798e-04 | 3.908 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.609309e-04 | 3.793 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 1.808632e-04 | 3.743 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.399046e-04 | 3.620 |
| R-HSA-8953854 | Metabolism of RNA | 4.119557e-04 | 3.385 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 4.520289e-04 | 3.345 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 5.262759e-04 | 3.279 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 5.606657e-04 | 3.251 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.643147e-04 | 3.248 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.980397e-04 | 3.223 |
| R-HSA-2682334 | EPH-Ephrin signaling | 6.333468e-04 | 3.198 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 7.492916e-04 | 3.125 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 7.914628e-04 | 3.102 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 7.914628e-04 | 3.102 |
| R-HSA-72764 | Eukaryotic Translation Termination | 7.914628e-04 | 3.102 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 8.044611e-04 | 3.094 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 8.433291e-04 | 3.074 |
| R-HSA-72312 | rRNA processing | 9.178403e-04 | 3.037 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 1.001632e-03 | 2.999 |
| R-HSA-422475 | Axon guidance | 1.067141e-03 | 2.972 |
| R-HSA-2408557 | Selenocysteine synthesis | 1.085469e-03 | 2.964 |
| R-HSA-192823 | Viral mRNA Translation | 1.200513e-03 | 2.921 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.258787e-03 | 2.900 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.530145e-03 | 2.815 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.603798e-03 | 2.795 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.603798e-03 | 2.795 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.634067e-03 | 2.787 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 1.726136e-03 | 2.763 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.926420e-03 | 2.715 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.926420e-03 | 2.715 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 2.147118e-03 | 2.668 |
| R-HSA-9675108 | Nervous system development | 2.126618e-03 | 2.672 |
| R-HSA-390522 | Striated Muscle Contraction | 2.520148e-03 | 2.599 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.502129e-03 | 2.602 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.502129e-03 | 2.602 |
| R-HSA-1227986 | Signaling by ERBB2 | 2.812893e-03 | 2.551 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.871357e-03 | 2.542 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 3.307169e-03 | 2.481 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 3.307169e-03 | 2.481 |
| R-HSA-373755 | Semaphorin interactions | 3.376314e-03 | 2.472 |
| R-HSA-9711097 | Cellular response to starvation | 3.533466e-03 | 2.452 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 3.709883e-03 | 2.431 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.258807e-03 | 2.371 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.426628e-03 | 2.354 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 5.841057e-03 | 2.234 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 5.841057e-03 | 2.234 |
| R-HSA-5683057 | MAPK family signaling cascades | 5.760912e-03 | 2.240 |
| R-HSA-1236394 | Signaling by ERBB4 | 6.142375e-03 | 2.212 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 6.329515e-03 | 2.199 |
| R-HSA-426117 | Cation-coupled Chloride cotransporters | 8.790540e-03 | 2.056 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 8.790540e-03 | 2.056 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 8.802503e-03 | 2.055 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 8.956673e-03 | 2.048 |
| R-HSA-9620244 | Long-term potentiation | 9.614965e-03 | 2.017 |
| R-HSA-196025 | Formation of annular gap junctions | 1.054038e-02 | 1.977 |
| R-HSA-9825895 | Regulation of MITF-M-dependent genes involved in DNA replication, damage repair ... | 1.054038e-02 | 1.977 |
| R-HSA-190873 | Gap junction degradation | 1.243062e-02 | 1.906 |
| R-HSA-176974 | Unwinding of DNA | 1.243062e-02 | 1.906 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 1.136721e-02 | 1.944 |
| R-HSA-5653656 | Vesicle-mediated transport | 1.242022e-02 | 1.906 |
| R-HSA-9818032 | NFE2L2 regulating MDR associated enzymes | 1.243062e-02 | 1.906 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 1.203446e-02 | 1.920 |
| R-HSA-1236974 | ER-Phagosome pathway | 1.255574e-02 | 1.901 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 1.306526e-02 | 1.884 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 1.431916e-02 | 1.844 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 1.329163e-02 | 1.876 |
| R-HSA-199991 | Membrane Trafficking | 1.299013e-02 | 1.886 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 1.431916e-02 | 1.844 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.386542e-02 | 1.858 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.452082e-02 | 1.838 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.797432e-02 | 1.745 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.797432e-02 | 1.745 |
| R-HSA-9930044 | Nuclear RNA decay | 1.766565e-02 | 1.753 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.766565e-02 | 1.753 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.674150e-02 | 1.776 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 1.797432e-02 | 1.745 |
| R-HSA-397014 | Muscle contraction | 1.682072e-02 | 1.774 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 1.797432e-02 | 1.745 |
| R-HSA-8848021 | Signaling by PTK6 | 1.797432e-02 | 1.745 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 1.720983e-02 | 1.764 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.821847e-02 | 1.739 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 1.890249e-02 | 1.723 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 2.131348e-02 | 1.671 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.054796e-02 | 1.687 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.011810e-02 | 1.696 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.011810e-02 | 1.696 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 2.141104e-02 | 1.669 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 1.966633e-02 | 1.706 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 2.171423e-02 | 1.663 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.238324e-02 | 1.650 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 2.238324e-02 | 1.650 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.739791e-02 | 1.562 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.555702e-02 | 1.592 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 2.413052e-02 | 1.617 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 2.615012e-02 | 1.583 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 2.649285e-02 | 1.577 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.717053e-02 | 1.566 |
| R-HSA-68886 | M Phase | 2.669749e-02 | 1.574 |
| R-HSA-69275 | G2/M Transition | 2.570977e-02 | 1.590 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.690046e-02 | 1.570 |
| R-HSA-1640170 | Cell Cycle | 2.710249e-02 | 1.567 |
| R-HSA-9700206 | Signaling by ALK in cancer | 2.634258e-02 | 1.579 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 2.634258e-02 | 1.579 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 2.743915e-02 | 1.562 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 2.743915e-02 | 1.562 |
| R-HSA-5617833 | Cilium Assembly | 2.812824e-02 | 1.551 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.854329e-02 | 1.544 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 2.925380e-02 | 1.534 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 2.925380e-02 | 1.534 |
| R-HSA-380287 | Centrosome maturation | 2.957672e-02 | 1.529 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.957672e-02 | 1.529 |
| R-HSA-68877 | Mitotic Prometaphase | 3.004041e-02 | 1.522 |
| R-HSA-9020591 | Interleukin-12 signaling | 3.070354e-02 | 1.513 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 3.122489e-02 | 1.505 |
| R-HSA-5674135 | MAP2K and MAPK activation | 3.170658e-02 | 1.499 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 3.170658e-02 | 1.499 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.199871e-02 | 1.495 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 3.303238e-02 | 1.481 |
| R-HSA-9912633 | Antigen processing: Ub, ATP-independent proteasomal degradation | 3.510026e-02 | 1.455 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.855928e-02 | 1.414 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 4.038088e-02 | 1.394 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 4.038088e-02 | 1.394 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 4.038088e-02 | 1.394 |
| R-HSA-6802949 | Signaling by RAS mutants | 4.038088e-02 | 1.394 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 4.038088e-02 | 1.394 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.817880e-02 | 1.418 |
| R-HSA-9659379 | Sensory processing of sound | 3.423451e-02 | 1.466 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 3.510026e-02 | 1.455 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 3.537048e-02 | 1.451 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 4.062375e-02 | 1.391 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 4.135637e-02 | 1.383 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 4.135637e-02 | 1.383 |
| R-HSA-3371556 | Cellular response to heat stress | 4.160203e-02 | 1.381 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 4.160203e-02 | 1.381 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 4.224536e-02 | 1.374 |
| R-HSA-449836 | Other interleukin signaling | 4.462966e-02 | 1.350 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 4.610183e-02 | 1.336 |
| R-HSA-447115 | Interleukin-12 family signaling | 4.619036e-02 | 1.335 |
| R-HSA-194138 | Signaling by VEGF | 4.727163e-02 | 1.325 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.764519e-02 | 1.322 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 4.799546e-02 | 1.319 |
| R-HSA-69481 | G2/M Checkpoints | 4.966173e-02 | 1.304 |
| R-HSA-5619104 | Defective SLC12A1 causes Bartter syndrome 1 (BS1) | 5.412865e-02 | 1.267 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.232160e-02 | 1.205 |
| R-HSA-72187 | mRNA 3'-end processing | 5.220067e-02 | 1.282 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 5.941074e-02 | 1.226 |
| R-HSA-392451 | G beta:gamma signalling through PI3Kgamma | 6.232160e-02 | 1.205 |
| R-HSA-68949 | Orc1 removal from chromatin | 5.220067e-02 | 1.282 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.690201e-02 | 1.245 |
| R-HSA-445355 | Smooth Muscle Contraction | 5.431603e-02 | 1.265 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 6.232160e-02 | 1.205 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 5.861666e-02 | 1.232 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 6.232160e-02 | 1.205 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 6.090416e-02 | 1.215 |
| R-HSA-9764561 | Regulation of CDH1 Function | 6.317957e-02 | 1.199 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.357146e-02 | 1.197 |
| R-HSA-8863678 | Neurodegenerative Diseases | 6.610394e-02 | 1.180 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 6.610394e-02 | 1.180 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 6.719869e-02 | 1.173 |
| R-HSA-209563 | Axonal growth stimulation | 6.719869e-02 | 1.173 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 6.719869e-02 | 1.173 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 6.719869e-02 | 1.173 |
| R-HSA-8939211 | ESR-mediated signaling | 6.963951e-02 | 1.157 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 6.996086e-02 | 1.155 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 6.996086e-02 | 1.155 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 7.023799e-02 | 1.153 |
| R-HSA-70171 | Glycolysis | 7.063311e-02 | 1.151 |
| R-HSA-198693 | AKT phosphorylates targets in the nucleus | 1.537899e-01 | 0.813 |
| R-HSA-9700645 | ALK mutants bind TKIs | 1.537899e-01 | 0.813 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 1.654886e-01 | 0.781 |
| R-HSA-5358493 | Synthesis of diphthamide-EEF2 | 1.884051e-01 | 0.725 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 1.996274e-01 | 0.700 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 9.026963e-02 | 1.044 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 9.451815e-02 | 1.024 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 9.451815e-02 | 1.024 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 2.323755e-01 | 0.634 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 2.323755e-01 | 0.634 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.031823e-01 | 0.986 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.031823e-01 | 0.986 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.075934e-01 | 0.968 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 2.429924e-01 | 0.614 |
| R-HSA-5083625 | Defective GALNT3 causes HFTC | 2.429924e-01 | 0.614 |
| R-HSA-5083636 | Defective GALNT12 causes CRCS1 | 2.429924e-01 | 0.614 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.165620e-01 | 0.933 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.637895e-01 | 0.579 |
| R-HSA-5083632 | Defective C1GALT1C1 causes TNPS | 2.637895e-01 | 0.579 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.350259e-01 | 0.870 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.397397e-01 | 0.855 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.840177e-01 | 0.547 |
| R-HSA-774815 | Nucleosome assembly | 1.686994e-01 | 0.773 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 1.686994e-01 | 0.773 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.441670e-01 | 0.841 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.441670e-01 | 0.841 |
| R-HSA-3214815 | HDACs deacetylate histones | 2.187902e-01 | 0.660 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 1.948239e-01 | 0.710 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.773944e-01 | 0.751 |
| R-HSA-72172 | mRNA Splicing | 2.034951e-01 | 0.691 |
| R-HSA-68962 | Activation of the pre-replicative complex | 9.026963e-02 | 1.044 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 2.090123e-01 | 0.680 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 8.274899e-02 | 1.082 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 9.280180e-02 | 1.032 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.537899e-01 | 0.813 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.086461e-01 | 0.681 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 9.280180e-02 | 1.032 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 9.451815e-02 | 1.024 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.086461e-01 | 0.681 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 2.534630e-01 | 0.596 |
| R-HSA-193697 | p75NTR regulates axonogenesis | 1.537899e-01 | 0.813 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 2.853197e-01 | 0.545 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 2.190467e-01 | 0.659 |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | 9.280180e-02 | 1.032 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 2.106951e-01 | 0.676 |
| R-HSA-3371568 | Attenuation phase | 1.397397e-01 | 0.855 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 1.935304e-01 | 0.713 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.018883e-01 | 0.695 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 1.989419e-01 | 0.701 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 8.995252e-02 | 1.046 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 1.409617e-01 | 0.851 |
| R-HSA-211163 | AKT-mediated inactivation of FOXO1A | 8.008892e-02 | 1.096 |
| R-HSA-8985586 | SLIT2:ROBO1 increases RHOA activity | 1.053398e-01 | 0.977 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 1.053398e-01 | 0.977 |
| R-HSA-193634 | Axonal growth inhibition (RHOA activation) | 1.419280e-01 | 0.848 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 2.106951e-01 | 0.676 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.257117e-01 | 0.901 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 2.739737e-01 | 0.562 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 2.739737e-01 | 0.562 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 1.985538e-01 | 0.702 |
| R-HSA-912446 | Meiotic recombination | 1.985538e-01 | 0.702 |
| R-HSA-3371571 | HSF1-dependent transactivation | 1.985538e-01 | 0.702 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.774510e-01 | 0.751 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 2.739737e-01 | 0.562 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.075934e-01 | 0.968 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 1.017316e-01 | 0.993 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.045744e-01 | 0.981 |
| R-HSA-68875 | Mitotic Prophase | 1.184105e-01 | 0.927 |
| R-HSA-2467813 | Separation of Sister Chromatids | 2.486449e-01 | 0.604 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 2.739737e-01 | 0.562 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 2.840177e-01 | 0.547 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 1.785686e-01 | 0.748 |
| R-HSA-72766 | Translation | 1.779259e-01 | 0.750 |
| R-HSA-2161517 | Abacavir transmembrane transport | 1.177052e-01 | 0.929 |
| R-HSA-9839383 | TGFBR3 PTM regulation | 1.419280e-01 | 0.848 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 1.654886e-01 | 0.781 |
| R-HSA-5635838 | Activation of SMO | 2.429924e-01 | 0.614 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 2.637895e-01 | 0.579 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.391927e-01 | 0.621 |
| R-HSA-191859 | snRNP Assembly | 2.391927e-01 | 0.621 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.494319e-01 | 0.603 |
| R-HSA-69306 | DNA Replication | 2.161408e-01 | 0.665 |
| R-HSA-9907900 | Proteasome assembly | 1.638011e-01 | 0.786 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 9.614177e-02 | 1.017 |
| R-HSA-6811438 | Intra-Golgi traffic | 1.492713e-01 | 0.826 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 1.451478e-01 | 0.838 |
| R-HSA-1234174 | Cellular response to hypoxia | 2.699417e-01 | 0.569 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.537899e-01 | 0.813 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 1.537899e-01 | 0.813 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 1.996274e-01 | 0.700 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.120540e-01 | 0.951 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 1.350259e-01 | 0.870 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.492713e-01 | 0.826 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 2.187902e-01 | 0.660 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 2.054431e-01 | 0.687 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.849480e-01 | 0.733 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.031823e-01 | 0.986 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 1.444888e-01 | 0.840 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 1.686994e-01 | 0.773 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 1.686994e-01 | 0.773 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 2.759813e-01 | 0.559 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.884051e-01 | 0.725 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 2.534630e-01 | 0.596 |
| R-HSA-416482 | G alpha (12/13) signalling events | 1.192445e-01 | 0.924 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 2.840177e-01 | 0.547 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 1.506490e-01 | 0.822 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 1.537899e-01 | 0.813 |
| R-HSA-5694530 | Cargo concentration in the ER | 9.451815e-02 | 1.024 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 7.266672e-02 | 1.139 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.397397e-01 | 0.855 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.444888e-01 | 0.840 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 8.727444e-02 | 1.059 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 1.794444e-01 | 0.746 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.975606e-01 | 0.704 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 2.340809e-01 | 0.631 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 2.414079e-01 | 0.617 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 2.534630e-01 | 0.596 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.278687e-01 | 0.893 |
| R-HSA-9664417 | Leishmania phagocytosis | 1.767138e-01 | 0.753 |
| R-HSA-9664407 | Parasite infection | 1.767138e-01 | 0.753 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 1.767138e-01 | 0.753 |
| R-HSA-69239 | Synthesis of DNA | 2.307010e-01 | 0.637 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.257117e-01 | 0.901 |
| R-HSA-437239 | Recycling pathway of L1 | 1.785686e-01 | 0.748 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 2.564928e-01 | 0.591 |
| R-HSA-5250982 | Toxicity of tetanus toxin (tetX) | 8.008892e-02 | 1.096 |
| R-HSA-5250989 | Toxicity of botulinum toxin type G (botG) | 9.280180e-02 | 1.032 |
| R-HSA-5250955 | Toxicity of botulinum toxin type D (botD) | 1.177052e-01 | 0.929 |
| R-HSA-5250981 | Toxicity of botulinum toxin type F (botF) | 1.177052e-01 | 0.929 |
| R-HSA-8964011 | HDL clearance | 1.177052e-01 | 0.929 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 1.299005e-01 | 0.886 |
| R-HSA-5250958 | Toxicity of botulinum toxin type B (botB) | 1.419280e-01 | 0.848 |
| R-HSA-9013700 | NOTCH4 Activation and Transmission of Signal to the Nucleus | 1.537899e-01 | 0.813 |
| R-HSA-193692 | Regulated proteolysis of p75NTR | 1.537899e-01 | 0.813 |
| R-HSA-198203 | PI3K/AKT activation | 1.654886e-01 | 0.781 |
| R-HSA-9614399 | Regulation of localization of FOXO transcription factors | 1.770263e-01 | 0.752 |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | 2.323755e-01 | 0.634 |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 2.323755e-01 | 0.634 |
| R-HSA-3000480 | Scavenging by Class A Receptors | 1.492713e-01 | 0.826 |
| R-HSA-190828 | Gap junction trafficking | 1.638011e-01 | 0.786 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.380228e-01 | 0.623 |
| R-HSA-162587 | HIV Life Cycle | 2.278269e-01 | 0.642 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.858673e-01 | 0.544 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 9.451815e-02 | 1.024 |
| R-HSA-391251 | Protein folding | 1.706282e-01 | 0.768 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 1.686994e-01 | 0.773 |
| R-HSA-162906 | HIV Infection | 2.616842e-01 | 0.582 |
| R-HSA-442380 | Zinc influx into cells by the SLC39 gene family | 1.537899e-01 | 0.813 |
| R-HSA-416550 | Sema4D mediated inhibition of cell attachment and migration | 1.884051e-01 | 0.725 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 2.216105e-01 | 0.654 |
| R-HSA-9675151 | Disorders of Developmental Biology | 2.534630e-01 | 0.596 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.350259e-01 | 0.870 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.885241e-01 | 0.725 |
| R-HSA-69206 | G1/S Transition | 1.327134e-01 | 0.877 |
| R-HSA-69242 | S Phase | 2.017789e-01 | 0.695 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.983484e-01 | 0.703 |
| R-HSA-1483249 | Inositol phosphate metabolism | 9.619591e-02 | 1.017 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 2.086461e-01 | 0.681 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.289757e-01 | 0.640 |
| R-HSA-70326 | Glucose metabolism | 1.115264e-01 | 0.953 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.849480e-01 | 0.733 |
| R-HSA-9833110 | RSV-host interactions | 2.198010e-01 | 0.658 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 1.770263e-01 | 0.752 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 2.216105e-01 | 0.654 |
| R-HSA-9856872 | Malate-aspartate shuttle | 2.216105e-01 | 0.654 |
| R-HSA-6814848 | Glycerophospholipid catabolism | 2.216105e-01 | 0.654 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 1.075934e-01 | 0.968 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 1.441670e-01 | 0.841 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.545570e-01 | 0.594 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 2.821188e-01 | 0.550 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.342607e-01 | 0.872 |
| R-HSA-69190 | DNA strand elongation | 9.882317e-02 | 1.005 |
| R-HSA-397795 | G-protein beta:gamma signalling | 1.031823e-01 | 0.986 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 7.807977e-02 | 1.107 |
| R-HSA-162582 | Signal Transduction | 1.915740e-01 | 0.718 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 1.996274e-01 | 0.700 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 7.788745e-02 | 1.109 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 2.106951e-01 | 0.676 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 2.429924e-01 | 0.614 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 2.596843e-01 | 0.586 |
| R-HSA-9793528 | Ciprofloxacin ADME | 2.216105e-01 | 0.654 |
| R-HSA-70263 | Gluconeogenesis | 1.835363e-01 | 0.736 |
| R-HSA-1266738 | Developmental Biology | 1.482123e-01 | 0.829 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.031823e-01 | 0.986 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.386314e-02 | 1.028 |
| R-HSA-913531 | Interferon Signaling | 1.133743e-01 | 0.945 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 1.770263e-01 | 0.752 |
| R-HSA-8876725 | Protein methylation | 2.323755e-01 | 0.634 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.070950e-01 | 0.970 |
| R-HSA-9645723 | Diseases of programmed cell death | 1.539248e-01 | 0.813 |
| R-HSA-165159 | MTOR signalling | 1.540853e-01 | 0.812 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.419280e-01 | 0.848 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 2.106951e-01 | 0.676 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.409617e-01 | 0.851 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 1.913154e-01 | 0.718 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 1.961173e-01 | 0.707 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 1.303492e-01 | 0.885 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 1.138007e-01 | 0.944 |
| R-HSA-373760 | L1CAM interactions | 2.714080e-01 | 0.566 |
| R-HSA-418990 | Adherens junctions interactions | 2.384149e-01 | 0.623 |
| R-HSA-180292 | GAB1 signalosome | 2.739737e-01 | 0.562 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 2.840177e-01 | 0.547 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 2.035928e-01 | 0.691 |
| R-HSA-9824446 | Viral Infection Pathways | 1.777098e-01 | 0.750 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.820418e-01 | 0.740 |
| R-HSA-9007101 | Rab regulation of trafficking | 2.751524e-01 | 0.560 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.070399e-01 | 0.970 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 7.388960e-02 | 1.131 |
| R-HSA-435354 | Zinc transporters | 2.216105e-01 | 0.654 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 2.790444e-01 | 0.554 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 2.790444e-01 | 0.554 |
| R-HSA-5663205 | Infectious disease | 2.091149e-01 | 0.680 |
| R-HSA-9006936 | Signaling by TGFB family members | 2.366952e-01 | 0.626 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.289757e-01 | 0.640 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 2.602113e-01 | 0.585 |
| R-HSA-156711 | Polo-like kinase mediated events | 2.739737e-01 | 0.562 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.589292e-01 | 0.799 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.378488e-01 | 0.624 |
| R-HSA-9711123 | Cellular response to chemical stress | 2.144266e-01 | 0.669 |
| R-HSA-177929 | Signaling by EGFR | 2.238784e-01 | 0.650 |
| R-HSA-168316 | Assembly of Viral Components at the Budding Site | 9.280180e-02 | 1.032 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 9.882317e-02 | 1.005 |
| R-HSA-211000 | Gene Silencing by RNA | 2.307010e-01 | 0.637 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.686099e-01 | 0.773 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 1.770263e-01 | 0.752 |
| R-HSA-168268 | Virus Assembly and Release | 2.429924e-01 | 0.614 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.913154e-01 | 0.718 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.983484e-01 | 0.703 |
| R-HSA-75153 | Apoptotic execution phase | 1.736224e-01 | 0.760 |
| R-HSA-9679504 | Translation of Replicase and Assembly of the Replication Transcription Complex | 2.739737e-01 | 0.562 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 2.655385e-01 | 0.576 |
| R-HSA-109581 | Apoptosis | 2.426530e-01 | 0.615 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.506490e-01 | 0.822 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 2.090123e-01 | 0.680 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 2.901794e-01 | 0.537 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 2.904398e-01 | 0.537 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 2.939234e-01 | 0.532 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.939234e-01 | 0.532 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.939234e-01 | 0.532 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.939234e-01 | 0.532 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.939234e-01 | 0.532 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 2.939234e-01 | 0.532 |
| R-HSA-9629569 | Protein hydroxylation | 2.939234e-01 | 0.532 |
| R-HSA-204005 | COPII-mediated vesicle transport | 2.955555e-01 | 0.529 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 2.955555e-01 | 0.529 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 2.977166e-01 | 0.526 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 3.006658e-01 | 0.522 |
| R-HSA-5632684 | Hedgehog 'on' state | 3.006658e-01 | 0.522 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 3.006658e-01 | 0.522 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 3.036926e-01 | 0.518 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 3.036926e-01 | 0.518 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.057701e-01 | 0.515 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 3.057701e-01 | 0.515 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 3.057701e-01 | 0.515 |
| R-HSA-1643685 | Disease | 3.071289e-01 | 0.513 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 3.099973e-01 | 0.509 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 3.108675e-01 | 0.507 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 3.133272e-01 | 0.504 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 3.159572e-01 | 0.500 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.159572e-01 | 0.500 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.159572e-01 | 0.500 |
| R-HSA-4839726 | Chromatin organization | 3.204577e-01 | 0.494 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.210384e-01 | 0.493 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 3.228291e-01 | 0.491 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 3.228291e-01 | 0.491 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 3.228291e-01 | 0.491 |
| R-HSA-168799 | Neurotoxicity of clostridium toxins | 3.228291e-01 | 0.491 |
| R-HSA-166208 | mTORC1-mediated signalling | 3.228291e-01 | 0.491 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 3.228291e-01 | 0.491 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 3.228291e-01 | 0.491 |
| R-HSA-9694676 | Translation of Replicase and Assembly of the Replication Transcription Complex | 3.228291e-01 | 0.491 |
| R-HSA-421270 | Cell-cell junction organization | 3.258928e-01 | 0.487 |
| R-HSA-5689603 | UCH proteinases | 3.261105e-01 | 0.487 |
| R-HSA-977068 | Termination of O-glycan biosynthesis | 3.322001e-01 | 0.479 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 3.322001e-01 | 0.479 |
| R-HSA-4086400 | PCP/CE pathway | 3.362242e-01 | 0.473 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 3.414420e-01 | 0.467 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 3.414420e-01 | 0.467 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 3.435397e-01 | 0.464 |
| R-HSA-74160 | Gene expression (Transcription) | 3.479055e-01 | 0.459 |
| R-HSA-6798695 | Neutrophil degranulation | 3.483740e-01 | 0.458 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 3.505566e-01 | 0.455 |
| R-HSA-3214842 | HDMs demethylate histones | 3.505566e-01 | 0.455 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 3.581678e-01 | 0.446 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 3.595456e-01 | 0.444 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 3.595456e-01 | 0.444 |
| R-HSA-70635 | Urea cycle | 3.595456e-01 | 0.444 |
| R-HSA-9845614 | Sphingolipid catabolism | 3.595456e-01 | 0.444 |
| R-HSA-2161522 | Abacavir ADME | 3.595456e-01 | 0.444 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 3.662749e-01 | 0.436 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 3.684107e-01 | 0.434 |
| R-HSA-171306 | Packaging Of Telomere Ends | 3.684107e-01 | 0.434 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 3.684107e-01 | 0.434 |
| R-HSA-389357 | CD28 dependent PI3K/Akt signaling | 3.684107e-01 | 0.434 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 3.684107e-01 | 0.434 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 3.684107e-01 | 0.434 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 3.684107e-01 | 0.434 |
| R-HSA-264876 | Insulin processing | 3.684107e-01 | 0.434 |
| R-HSA-9828806 | Maturation of hRSV A proteins | 3.684107e-01 | 0.434 |
| R-HSA-6807070 | PTEN Regulation | 3.694607e-01 | 0.432 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 3.695009e-01 | 0.432 |
| R-HSA-1500620 | Meiosis | 3.712347e-01 | 0.430 |
| R-HSA-1632852 | Macroautophagy | 3.769703e-01 | 0.424 |
| R-HSA-167287 | HIV elongation arrest and recovery | 3.771536e-01 | 0.423 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 3.771536e-01 | 0.423 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 3.771536e-01 | 0.423 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 3.811073e-01 | 0.419 |
| R-HSA-5357801 | Programmed Cell Death | 3.820349e-01 | 0.418 |
| R-HSA-5334118 | DNA methylation | 3.857760e-01 | 0.414 |
| R-HSA-9615710 | Late endosomal microautophagy | 3.857760e-01 | 0.414 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 3.857760e-01 | 0.414 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 3.857760e-01 | 0.414 |
| R-HSA-210745 | Regulation of gene expression in beta cells | 3.857760e-01 | 0.414 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 3.942796e-01 | 0.404 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 3.942796e-01 | 0.404 |
| R-HSA-114452 | Activation of BH3-only proteins | 3.942796e-01 | 0.404 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 3.976234e-01 | 0.401 |
| R-HSA-446728 | Cell junction organization | 3.997884e-01 | 0.398 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 4.026660e-01 | 0.395 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 4.026660e-01 | 0.395 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 4.026660e-01 | 0.395 |
| R-HSA-8963693 | Aspartate and asparagine metabolism | 4.026660e-01 | 0.395 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 4.054931e-01 | 0.392 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 4.076192e-01 | 0.390 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 4.109368e-01 | 0.386 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.109368e-01 | 0.386 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 4.109368e-01 | 0.386 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 4.142021e-01 | 0.383 |
| R-HSA-68882 | Mitotic Anaphase | 4.163339e-01 | 0.381 |
| R-HSA-354192 | Integrin signaling | 4.190936e-01 | 0.378 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 4.190936e-01 | 0.378 |
| R-HSA-68616 | Assembly of the ORC complex at the origin of replication | 4.190936e-01 | 0.378 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 4.190936e-01 | 0.378 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 4.190936e-01 | 0.378 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.194339e-01 | 0.377 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 4.201076e-01 | 0.377 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 4.271379e-01 | 0.369 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 4.271379e-01 | 0.369 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 4.271379e-01 | 0.369 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 4.271379e-01 | 0.369 |
| R-HSA-8964539 | Glutamate and glutamine metabolism | 4.271379e-01 | 0.369 |
| R-HSA-189483 | Heme degradation | 4.271379e-01 | 0.369 |
| R-HSA-73887 | Death Receptor Signaling | 4.289067e-01 | 0.368 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 4.350713e-01 | 0.361 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 4.350713e-01 | 0.361 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 4.350713e-01 | 0.361 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 4.350713e-01 | 0.361 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 4.350713e-01 | 0.361 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 4.350713e-01 | 0.361 |
| R-HSA-1980145 | Signaling by NOTCH2 | 4.350713e-01 | 0.361 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 4.350713e-01 | 0.361 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 4.350713e-01 | 0.361 |
| R-HSA-9612973 | Autophagy | 4.362107e-01 | 0.360 |
| R-HSA-9610379 | HCMV Late Events | 4.398498e-01 | 0.357 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 4.428954e-01 | 0.354 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 4.428954e-01 | 0.354 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 4.428954e-01 | 0.354 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 4.428954e-01 | 0.354 |
| R-HSA-169911 | Regulation of Apoptosis | 4.428954e-01 | 0.354 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 4.506115e-01 | 0.346 |
| R-HSA-8853659 | RET signaling | 4.506115e-01 | 0.346 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 4.506115e-01 | 0.346 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4.506115e-01 | 0.346 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 4.506115e-01 | 0.346 |
| R-HSA-3371511 | HSF1 activation | 4.506115e-01 | 0.346 |
| R-HSA-114604 | GPVI-mediated activation cascade | 4.506115e-01 | 0.346 |
| R-HSA-111933 | Calmodulin induced events | 4.506115e-01 | 0.346 |
| R-HSA-111997 | CaM pathway | 4.506115e-01 | 0.346 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 4.506115e-01 | 0.346 |
| R-HSA-74158 | RNA Polymerase III Transcription | 4.506115e-01 | 0.346 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 4.506115e-01 | 0.346 |
| R-HSA-3214847 | HATs acetylate histones | 4.528161e-01 | 0.344 |
| R-HSA-195721 | Signaling by WNT | 4.541277e-01 | 0.343 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 4.582213e-01 | 0.339 |
| R-HSA-4641258 | Degradation of DVL | 4.582213e-01 | 0.339 |
| R-HSA-4641257 | Degradation of AXIN | 4.582213e-01 | 0.339 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 4.582213e-01 | 0.339 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 4.582213e-01 | 0.339 |
| R-HSA-110331 | Cleavage of the damaged purine | 4.582213e-01 | 0.339 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 4.582213e-01 | 0.339 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 4.657261e-01 | 0.332 |
| R-HSA-73927 | Depurination | 4.657261e-01 | 0.332 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.714355e-01 | 0.327 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 4.731274e-01 | 0.325 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 4.731274e-01 | 0.325 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 4.731274e-01 | 0.325 |
| R-HSA-69541 | Stabilization of p53 | 4.731274e-01 | 0.325 |
| R-HSA-71336 | Pentose phosphate pathway | 4.731274e-01 | 0.325 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 4.731274e-01 | 0.325 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 4.731274e-01 | 0.325 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 4.731274e-01 | 0.325 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 4.756670e-01 | 0.323 |
| R-HSA-5619102 | SLC transporter disorders | 4.757173e-01 | 0.323 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 4.801679e-01 | 0.319 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 4.801679e-01 | 0.319 |
| R-HSA-9646399 | Aggrephagy | 4.804266e-01 | 0.318 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 4.804266e-01 | 0.318 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 4.804266e-01 | 0.318 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 4.804266e-01 | 0.318 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 4.804266e-01 | 0.318 |
| R-HSA-167169 | HIV Transcription Elongation | 4.804266e-01 | 0.318 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.804266e-01 | 0.318 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 4.804266e-01 | 0.318 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 4.876252e-01 | 0.312 |
| R-HSA-9821002 | Chromatin modifications during the maternal to zygotic transition (MZT) | 4.876252e-01 | 0.312 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 4.876252e-01 | 0.312 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 4.876252e-01 | 0.312 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 4.876252e-01 | 0.312 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 4.876252e-01 | 0.312 |
| R-HSA-9607240 | FLT3 Signaling | 4.876252e-01 | 0.312 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.890985e-01 | 0.311 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 4.928325e-01 | 0.307 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 4.947244e-01 | 0.306 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 4.947244e-01 | 0.306 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 4.947244e-01 | 0.306 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 4.947244e-01 | 0.306 |
| R-HSA-189451 | Heme biosynthesis | 4.947244e-01 | 0.306 |
| R-HSA-111996 | Ca-dependent events | 5.017257e-01 | 0.300 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 5.017257e-01 | 0.300 |
| R-HSA-73928 | Depyrimidination | 5.017257e-01 | 0.300 |
| R-HSA-1500931 | Cell-Cell communication | 5.018766e-01 | 0.299 |
| R-HSA-202403 | TCR signaling | 5.066698e-01 | 0.295 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.070769e-01 | 0.295 |
| R-HSA-9710421 | Defective pyroptosis | 5.086305e-01 | 0.294 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 5.086305e-01 | 0.294 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 5.086305e-01 | 0.294 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.100267e-01 | 0.292 |
| R-HSA-3214858 | RMTs methylate histone arginines | 5.154399e-01 | 0.288 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 5.154399e-01 | 0.288 |
| R-HSA-168256 | Immune System | 5.170882e-01 | 0.286 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 5.221555e-01 | 0.282 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 5.221555e-01 | 0.282 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 5.221555e-01 | 0.282 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 5.221555e-01 | 0.282 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 5.221555e-01 | 0.282 |
| R-HSA-1489509 | DAG and IP3 signaling | 5.221555e-01 | 0.282 |
| R-HSA-9824272 | Somitogenesis | 5.221555e-01 | 0.282 |
| R-HSA-1614558 | Degradation of cysteine and homocysteine | 5.221555e-01 | 0.282 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 5.238455e-01 | 0.281 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 5.287783e-01 | 0.277 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 5.287783e-01 | 0.277 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 5.287783e-01 | 0.277 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.287783e-01 | 0.277 |
| R-HSA-9675135 | Diseases of DNA repair | 5.287783e-01 | 0.277 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 5.287783e-01 | 0.277 |
| R-HSA-9839373 | Signaling by TGFBR3 | 5.287783e-01 | 0.277 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 5.322821e-01 | 0.274 |
| R-HSA-5688426 | Deubiquitination | 5.331397e-01 | 0.273 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 5.353098e-01 | 0.271 |
| R-HSA-5620924 | Intraflagellar transport | 5.417512e-01 | 0.266 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.417512e-01 | 0.266 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.417512e-01 | 0.266 |
| R-HSA-425410 | Metal ion SLC transporters | 5.417512e-01 | 0.266 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 5.417512e-01 | 0.266 |
| R-HSA-9766229 | Degradation of CDH1 | 5.481036e-01 | 0.261 |
| R-HSA-389661 | Glyoxylate metabolism and glycine degradation | 5.481036e-01 | 0.261 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 5.481036e-01 | 0.261 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 5.481036e-01 | 0.261 |
| R-HSA-5693538 | Homology Directed Repair | 5.488486e-01 | 0.261 |
| R-HSA-9679506 | SARS-CoV Infections | 5.513474e-01 | 0.259 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 5.529257e-01 | 0.257 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 5.605467e-01 | 0.251 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 5.605467e-01 | 0.251 |
| R-HSA-2514856 | The phototransduction cascade | 5.605467e-01 | 0.251 |
| R-HSA-73886 | Chromosome Maintenance | 5.610021e-01 | 0.251 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 5.610021e-01 | 0.251 |
| R-HSA-597592 | Post-translational protein modification | 5.643057e-01 | 0.248 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 5.666397e-01 | 0.247 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 5.666397e-01 | 0.247 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 5.666397e-01 | 0.247 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 5.666397e-01 | 0.247 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 5.666397e-01 | 0.247 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 5.666397e-01 | 0.247 |
| R-HSA-2132295 | MHC class II antigen presentation | 5.689743e-01 | 0.245 |
| R-HSA-1221632 | Meiotic synapsis | 5.726487e-01 | 0.242 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 5.726487e-01 | 0.242 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 5.726487e-01 | 0.242 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 5.726487e-01 | 0.242 |
| R-HSA-9609690 | HCMV Early Events | 5.762306e-01 | 0.239 |
| R-HSA-72649 | Translation initiation complex formation | 5.785746e-01 | 0.238 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 5.785746e-01 | 0.238 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 5.785746e-01 | 0.238 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 5.785746e-01 | 0.238 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 5.807364e-01 | 0.236 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 5.807364e-01 | 0.236 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 5.807364e-01 | 0.236 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 5.844188e-01 | 0.233 |
| R-HSA-9753281 | Paracetamol ADME | 5.844188e-01 | 0.233 |
| R-HSA-9012852 | Signaling by NOTCH3 | 5.844188e-01 | 0.233 |
| R-HSA-392499 | Metabolism of proteins | 5.879946e-01 | 0.231 |
| R-HSA-114608 | Platelet degranulation | 5.884465e-01 | 0.230 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 5.901823e-01 | 0.229 |
| R-HSA-193648 | NRAGE signals death through JNK | 5.901823e-01 | 0.229 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 5.901823e-01 | 0.229 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 5.901823e-01 | 0.229 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 5.901823e-01 | 0.229 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 5.901823e-01 | 0.229 |
| R-HSA-428157 | Sphingolipid metabolism | 5.917842e-01 | 0.228 |
| R-HSA-5621480 | Dectin-2 family | 5.958661e-01 | 0.225 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 6.014716e-01 | 0.221 |
| R-HSA-9772572 | Early SARS-CoV-2 Infection Events | 6.014716e-01 | 0.221 |
| R-HSA-1474165 | Reproduction | 6.035512e-01 | 0.219 |
| R-HSA-9658195 | Leishmania infection | 6.042766e-01 | 0.219 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.042766e-01 | 0.219 |
| R-HSA-73857 | RNA Polymerase II Transcription | 6.054116e-01 | 0.218 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.069996e-01 | 0.217 |
| R-HSA-186712 | Regulation of beta-cell development | 6.069996e-01 | 0.217 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 6.109458e-01 | 0.214 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 6.109458e-01 | 0.214 |
| R-HSA-8873719 | RAB geranylgeranylation | 6.124512e-01 | 0.213 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 6.124512e-01 | 0.213 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 6.124512e-01 | 0.213 |
| R-HSA-351202 | Metabolism of polyamines | 6.124512e-01 | 0.213 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 6.124512e-01 | 0.213 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 6.124512e-01 | 0.213 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 6.124512e-01 | 0.213 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 6.124512e-01 | 0.213 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 6.124512e-01 | 0.213 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 6.124512e-01 | 0.213 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.146037e-01 | 0.211 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.178276e-01 | 0.209 |
| R-HSA-112043 | PLC beta mediated events | 6.178276e-01 | 0.209 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 6.178276e-01 | 0.209 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 6.231297e-01 | 0.205 |
| R-HSA-9707616 | Heme signaling | 6.231297e-01 | 0.205 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.231297e-01 | 0.205 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 6.231297e-01 | 0.205 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 6.231297e-01 | 0.205 |
| R-HSA-186797 | Signaling by PDGF | 6.231297e-01 | 0.205 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 6.275890e-01 | 0.202 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 6.289729e-01 | 0.201 |
| R-HSA-163685 | Integration of energy metabolism | 6.289729e-01 | 0.201 |
| R-HSA-5358351 | Signaling by Hedgehog | 6.360005e-01 | 0.197 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 6.436158e-01 | 0.191 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.485617e-01 | 0.188 |
| R-HSA-5693606 | DNA Double Strand Break Response | 6.485617e-01 | 0.188 |
| R-HSA-112040 | G-protein mediated events | 6.485617e-01 | 0.188 |
| R-HSA-196807 | Nicotinate metabolism | 6.485617e-01 | 0.188 |
| R-HSA-913709 | O-linked glycosylation of mucins | 6.534392e-01 | 0.185 |
| R-HSA-167172 | Transcription of the HIV genome | 6.534392e-01 | 0.185 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 6.629930e-01 | 0.178 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 6.629930e-01 | 0.178 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 6.629930e-01 | 0.178 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 6.629930e-01 | 0.178 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 6.629930e-01 | 0.178 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 6.665713e-01 | 0.176 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 6.676711e-01 | 0.175 |
| R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 6.676711e-01 | 0.175 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 6.676711e-01 | 0.175 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 6.676711e-01 | 0.175 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 6.676711e-01 | 0.175 |
| R-HSA-189445 | Metabolism of porphyrins | 6.676711e-01 | 0.175 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 6.722846e-01 | 0.172 |
| R-HSA-9758941 | Gastrulation | 6.759944e-01 | 0.170 |
| R-HSA-9679191 | Potential therapeutics for SARS | 6.791612e-01 | 0.168 |
| R-HSA-449147 | Signaling by Interleukins | 6.792662e-01 | 0.168 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 6.813211e-01 | 0.167 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 6.854196e-01 | 0.164 |
| R-HSA-917937 | Iron uptake and transport | 6.857459e-01 | 0.164 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 6.885112e-01 | 0.162 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 6.901095e-01 | 0.161 |
| R-HSA-1980143 | Signaling by NOTCH1 | 6.901095e-01 | 0.161 |
| R-HSA-212436 | Generic Transcription Pathway | 6.963313e-01 | 0.157 |
| R-HSA-73864 | RNA Polymerase I Transcription | 6.986566e-01 | 0.156 |
| R-HSA-216083 | Integrin cell surface interactions | 6.986566e-01 | 0.156 |
| R-HSA-5619084 | ABC transporter disorders | 6.986566e-01 | 0.156 |
| R-HSA-168249 | Innate Immune System | 7.004007e-01 | 0.155 |
| R-HSA-157118 | Signaling by NOTCH | 7.025136e-01 | 0.153 |
| R-HSA-112315 | Transmission across Chemical Synapses | 7.043141e-01 | 0.152 |
| R-HSA-877300 | Interferon gamma signaling | 7.065415e-01 | 0.151 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.069690e-01 | 0.151 |
| R-HSA-9833482 | PKR-mediated signaling | 7.069690e-01 | 0.151 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 7.069690e-01 | 0.151 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.094609e-01 | 0.149 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 7.110392e-01 | 0.148 |
| R-HSA-977225 | Amyloid fiber formation | 7.110392e-01 | 0.148 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 7.150531e-01 | 0.146 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 7.190114e-01 | 0.143 |
| R-HSA-1474244 | Extracellular matrix organization | 7.211494e-01 | 0.142 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 7.229151e-01 | 0.141 |
| R-HSA-9609646 | HCMV Infection | 7.263391e-01 | 0.139 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 7.305611e-01 | 0.136 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 7.343050e-01 | 0.134 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 7.343050e-01 | 0.134 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.399074e-01 | 0.131 |
| R-HSA-72306 | tRNA processing | 7.400019e-01 | 0.131 |
| R-HSA-9663891 | Selective autophagy | 7.416381e-01 | 0.130 |
| R-HSA-418555 | G alpha (s) signalling events | 7.426384e-01 | 0.129 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.426384e-01 | 0.129 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 7.452521e-01 | 0.128 |
| R-HSA-5689880 | Ub-specific processing proteases | 7.478431e-01 | 0.126 |
| R-HSA-112310 | Neurotransmitter release cycle | 7.487697e-01 | 0.126 |
| R-HSA-73884 | Base Excision Repair | 7.487697e-01 | 0.126 |
| R-HSA-202424 | Downstream TCR signaling | 7.487697e-01 | 0.126 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 7.522617e-01 | 0.124 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 7.529576e-01 | 0.123 |
| R-HSA-9734767 | Developmental Cell Lineages | 7.550603e-01 | 0.122 |
| R-HSA-416476 | G alpha (q) signalling events | 7.571663e-01 | 0.121 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 7.591013e-01 | 0.120 |
| R-HSA-9837999 | Mitochondrial protein degradation | 7.657529e-01 | 0.116 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 7.690098e-01 | 0.114 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 7.753890e-01 | 0.110 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 7.753890e-01 | 0.110 |
| R-HSA-73894 | DNA Repair | 7.762428e-01 | 0.110 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 7.774347e-01 | 0.109 |
| R-HSA-157579 | Telomere Maintenance | 7.785125e-01 | 0.109 |
| R-HSA-422356 | Regulation of insulin secretion | 7.815928e-01 | 0.107 |
| R-HSA-5610787 | Hedgehog 'off' state | 7.876260e-01 | 0.104 |
| R-HSA-382556 | ABC-family proteins mediated transport | 7.876260e-01 | 0.104 |
| R-HSA-9020702 | Interleukin-1 signaling | 7.905801e-01 | 0.102 |
| R-HSA-168898 | Toll-like Receptor Cascades | 7.907484e-01 | 0.102 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 7.934932e-01 | 0.100 |
| R-HSA-1483255 | PI Metabolism | 7.934932e-01 | 0.100 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 7.937695e-01 | 0.100 |
| R-HSA-111885 | Opioid Signalling | 7.991991e-01 | 0.097 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 8.047480e-01 | 0.094 |
| R-HSA-5696398 | Nucleotide Excision Repair | 8.047480e-01 | 0.094 |
| R-HSA-389948 | Co-inhibition by PD-1 | 8.096979e-01 | 0.092 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 8.127864e-01 | 0.090 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 8.179614e-01 | 0.087 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 8.179614e-01 | 0.087 |
| R-HSA-9824439 | Bacterial Infection Pathways | 8.253051e-01 | 0.083 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 8.254581e-01 | 0.083 |
| R-HSA-2980736 | Peptide hormone metabolism | 8.395418e-01 | 0.076 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 8.524938e-01 | 0.069 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 8.524938e-01 | 0.069 |
| R-HSA-6809371 | Formation of the cornified envelope | 8.545489e-01 | 0.068 |
| R-HSA-977606 | Regulation of Complement cascade | 8.565755e-01 | 0.067 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 8.644046e-01 | 0.063 |
| R-HSA-8956319 | Nucleotide catabolism | 8.662944e-01 | 0.062 |
| R-HSA-388396 | GPCR downstream signalling | 8.669999e-01 | 0.062 |
| R-HSA-5576891 | Cardiac conduction | 8.718081e-01 | 0.060 |
| R-HSA-9843745 | Adipogenesis | 8.718081e-01 | 0.060 |
| R-HSA-15869 | Metabolism of nucleotides | 8.724942e-01 | 0.059 |
| R-HSA-9909396 | Circadian clock | 8.735952e-01 | 0.059 |
| R-HSA-1280218 | Adaptive Immune System | 8.820565e-01 | 0.055 |
| R-HSA-5173105 | O-linked glycosylation | 8.838089e-01 | 0.054 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 8.961601e-01 | 0.048 |
| R-HSA-166658 | Complement cascade | 8.976091e-01 | 0.047 |
| R-HSA-2187338 | Visual phototransduction | 9.004469e-01 | 0.046 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 9.018364e-01 | 0.045 |
| R-HSA-166520 | Signaling by NTRKs | 9.018364e-01 | 0.045 |
| R-HSA-446652 | Interleukin-1 family signaling | 9.072036e-01 | 0.042 |
| R-HSA-9609507 | Protein localization | 9.084992e-01 | 0.042 |
| R-HSA-112316 | Neuronal System | 9.107042e-01 | 0.041 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 9.147116e-01 | 0.039 |
| R-HSA-372790 | Signaling by GPCR | 9.251267e-01 | 0.034 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 9.317281e-01 | 0.031 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 9.319054e-01 | 0.031 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 9.319054e-01 | 0.031 |
| R-HSA-611105 | Respiratory electron transport | 9.365345e-01 | 0.028 |
| R-HSA-2559583 | Cellular Senescence | 9.382972e-01 | 0.028 |
| R-HSA-418594 | G alpha (i) signalling events | 9.383510e-01 | 0.028 |
| R-HSA-3781865 | Diseases of glycosylation | 9.416778e-01 | 0.026 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 9.478955e-01 | 0.023 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 9.553814e-01 | 0.020 |
| R-HSA-6805567 | Keratinization | 9.578294e-01 | 0.019 |
| R-HSA-9748784 | Drug ADME | 9.643995e-01 | 0.016 |
| R-HSA-8951664 | Neddylation | 9.658761e-01 | 0.015 |
| R-HSA-109582 | Hemostasis | 9.697714e-01 | 0.013 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 9.699499e-01 | 0.013 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 9.856046e-01 | 0.006 |
| R-HSA-1483257 | Phospholipid metabolism | 9.880284e-01 | 0.005 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 9.937727e-01 | 0.003 |
| R-HSA-382551 | Transport of small molecules | 9.952611e-01 | 0.002 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.955119e-01 | 0.002 |
| R-HSA-5668914 | Diseases of metabolism | 9.982004e-01 | 0.001 |
| R-HSA-9709957 | Sensory Perception | 9.999195e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999975e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999994e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.867 | -0.024 | 1 | 0.802 |
PKR |
0.866 | 0.078 | 1 | 0.854 |
TTK |
0.865 | 0.161 | -2 | 0.821 |
TAK1 |
0.864 | 0.008 | 1 | 0.792 |
ALK2 |
0.863 | 0.394 | -2 | 0.900 |
ALK4 |
0.863 | 0.337 | -2 | 0.907 |
EEF2K |
0.863 | 0.122 | 3 | 0.879 |
VRK2 |
0.860 | -0.155 | 1 | 0.883 |
BRAF |
0.859 | 0.049 | -4 | 0.853 |
BMPR1B |
0.858 | 0.401 | 1 | 0.791 |
TNIK |
0.857 | 0.028 | 3 | 0.905 |
ALPHAK3 |
0.856 | 0.069 | -1 | 0.782 |
VRK1 |
0.856 | -0.143 | 2 | 0.835 |
MEKK2 |
0.856 | 0.027 | 2 | 0.812 |
OSR1 |
0.856 | 0.078 | 2 | 0.796 |
BMPR2 |
0.855 | 0.136 | -2 | 0.864 |
LRRK2 |
0.855 | -0.129 | 2 | 0.852 |
MST2 |
0.855 | 0.024 | 1 | 0.771 |
NEK1 |
0.855 | -0.072 | 1 | 0.789 |
MINK |
0.855 | -0.039 | 1 | 0.758 |
MST1 |
0.855 | -0.001 | 1 | 0.762 |
CAMKK1 |
0.854 | -0.020 | -2 | 0.777 |
BMPR1A |
0.854 | 0.427 | 1 | 0.787 |
NEK8 |
0.853 | 0.045 | 2 | 0.834 |
NEK5 |
0.853 | -0.011 | 1 | 0.806 |
TAO2 |
0.852 | -0.036 | 2 | 0.864 |
TGFBR1 |
0.852 | 0.336 | -2 | 0.897 |
CAMKK2 |
0.851 | -0.055 | -2 | 0.771 |
ASK1 |
0.851 | -0.144 | 1 | 0.750 |
MEK1 |
0.851 | -0.120 | 2 | 0.830 |
MYO3A |
0.850 | 0.015 | 1 | 0.782 |
HGK |
0.850 | -0.028 | 3 | 0.904 |
GCK |
0.849 | -0.072 | 1 | 0.753 |
MYO3B |
0.849 | 0.001 | 2 | 0.845 |
MEK5 |
0.849 | -0.174 | 2 | 0.826 |
TAO3 |
0.849 | 0.019 | 1 | 0.785 |
NIK |
0.849 | -0.075 | -3 | 0.814 |
ACVR2B |
0.848 | 0.289 | -2 | 0.861 |
ACVR2A |
0.847 | 0.275 | -2 | 0.854 |
ANKRD3 |
0.847 | 0.003 | 1 | 0.830 |
LKB1 |
0.846 | -0.110 | -3 | 0.781 |
MEKK1 |
0.846 | -0.067 | 1 | 0.796 |
MOS |
0.845 | 0.127 | 1 | 0.879 |
MST3 |
0.845 | -0.003 | 2 | 0.852 |
NEK4 |
0.845 | -0.095 | 1 | 0.768 |
PERK |
0.844 | 0.088 | -2 | 0.866 |
NLK |
0.844 | 0.122 | 1 | 0.873 |
PDK1 |
0.843 | -0.149 | 1 | 0.785 |
PRPK |
0.843 | -0.067 | -1 | 0.825 |
KHS2 |
0.843 | -0.024 | 1 | 0.753 |
KHS1 |
0.843 | -0.074 | 1 | 0.749 |
PRP4 |
0.842 | 0.094 | -3 | 0.731 |
MEKK3 |
0.842 | -0.063 | 1 | 0.780 |
YSK1 |
0.842 | -0.070 | 2 | 0.828 |
DLK |
0.841 | -0.120 | 1 | 0.818 |
BIKE |
0.841 | -0.064 | 1 | 0.666 |
MAP3K15 |
0.841 | -0.167 | 1 | 0.759 |
ZAK |
0.841 | -0.030 | 1 | 0.776 |
STLK3 |
0.841 | -0.146 | 1 | 0.742 |
CAMLCK |
0.840 | -0.091 | -2 | 0.786 |
DAPK2 |
0.840 | -0.129 | -3 | 0.788 |
MEK2 |
0.839 | -0.193 | 2 | 0.808 |
JNK3 |
0.839 | 0.147 | 1 | 0.746 |
YSK4 |
0.839 | -0.056 | 1 | 0.750 |
HPK1 |
0.838 | -0.116 | 1 | 0.738 |
JNK2 |
0.837 | 0.148 | 1 | 0.705 |
P38A |
0.837 | 0.111 | 1 | 0.778 |
HRI |
0.837 | 0.006 | -2 | 0.848 |
MLK1 |
0.836 | 0.095 | 2 | 0.834 |
NEK11 |
0.836 | -0.190 | 1 | 0.760 |
LATS1 |
0.835 | 0.003 | -3 | 0.763 |
TLK1 |
0.835 | 0.104 | -2 | 0.841 |
CAMK1B |
0.835 | -0.098 | -3 | 0.788 |
LOK |
0.834 | -0.060 | -2 | 0.741 |
PLK1 |
0.834 | 0.072 | -2 | 0.820 |
TLK2 |
0.834 | 0.102 | 1 | 0.794 |
MEKK6 |
0.834 | -0.209 | 1 | 0.777 |
PINK1 |
0.834 | 0.076 | 1 | 0.861 |
ATR |
0.834 | -0.046 | 1 | 0.819 |
DSTYK |
0.834 | 0.232 | 2 | 0.880 |
CLK3 |
0.833 | 0.295 | 1 | 0.909 |
P38B |
0.833 | 0.126 | 1 | 0.721 |
GRK6 |
0.832 | 0.090 | 1 | 0.830 |
GRK7 |
0.832 | 0.154 | 1 | 0.779 |
CDKL1 |
0.832 | -0.043 | -3 | 0.711 |
MLK2 |
0.831 | -0.090 | 2 | 0.827 |
MPSK1 |
0.831 | -0.109 | 1 | 0.781 |
RAF1 |
0.831 | -0.050 | 1 | 0.816 |
NEK9 |
0.830 | -0.050 | 2 | 0.847 |
PASK |
0.830 | -0.091 | -3 | 0.770 |
MLK4 |
0.830 | 0.124 | 2 | 0.744 |
MLK3 |
0.829 | 0.150 | 2 | 0.776 |
ERK2 |
0.829 | 0.130 | 1 | 0.754 |
DMPK1 |
0.829 | -0.039 | -3 | 0.670 |
SMMLCK |
0.829 | -0.111 | -3 | 0.730 |
PBK |
0.829 | -0.121 | 1 | 0.716 |
ERK5 |
0.828 | 0.042 | 1 | 0.822 |
ICK |
0.828 | -0.038 | -3 | 0.747 |
CHAK2 |
0.827 | 0.017 | -1 | 0.810 |
GRK5 |
0.827 | -0.011 | -3 | 0.826 |
COT |
0.827 | 0.171 | 2 | 0.861 |
TAO1 |
0.827 | -0.084 | 1 | 0.718 |
DAPK3 |
0.826 | -0.078 | -3 | 0.706 |
CAMK2G |
0.826 | -0.022 | 2 | 0.814 |
AAK1 |
0.825 | -0.043 | 1 | 0.565 |
ROCK2 |
0.825 | -0.056 | -3 | 0.689 |
CDK5 |
0.825 | 0.185 | 1 | 0.775 |
SLK |
0.825 | -0.054 | -2 | 0.696 |
NEK7 |
0.824 | 0.126 | -3 | 0.817 |
P38G |
0.824 | 0.149 | 1 | 0.649 |
NEK2 |
0.823 | -0.079 | 2 | 0.824 |
IRAK4 |
0.822 | -0.078 | 1 | 0.812 |
NEK6 |
0.822 | 0.203 | -2 | 0.848 |
CDK1 |
0.821 | 0.185 | 1 | 0.724 |
PLK3 |
0.820 | 0.046 | 2 | 0.757 |
P38D |
0.820 | 0.147 | 1 | 0.662 |
TGFBR2 |
0.820 | 0.190 | -2 | 0.862 |
WNK4 |
0.819 | -0.162 | -2 | 0.778 |
ERK1 |
0.819 | 0.134 | 1 | 0.708 |
PDHK4 |
0.819 | -0.273 | 1 | 0.839 |
SKMLCK |
0.819 | -0.103 | -2 | 0.764 |
HASPIN |
0.818 | -0.010 | -1 | 0.647 |
NEK3 |
0.817 | -0.153 | 1 | 0.753 |
PKCD |
0.817 | 0.030 | 2 | 0.813 |
BUB1 |
0.817 | 0.013 | -5 | 0.696 |
CHAK1 |
0.817 | -0.040 | 2 | 0.775 |
PDHK1 |
0.817 | -0.220 | 1 | 0.830 |
HIPK1 |
0.816 | 0.071 | 1 | 0.821 |
CDC7 |
0.816 | 0.083 | 1 | 0.848 |
WNK1 |
0.816 | -0.089 | -2 | 0.779 |
IRE2 |
0.816 | 0.076 | 2 | 0.782 |
GRK2 |
0.816 | 0.002 | -2 | 0.721 |
JNK1 |
0.815 | 0.115 | 1 | 0.699 |
PKN3 |
0.815 | -0.053 | -3 | 0.734 |
TSSK2 |
0.814 | -0.096 | -5 | 0.733 |
ERK7 |
0.814 | 0.042 | 2 | 0.555 |
MST4 |
0.814 | 0.016 | 2 | 0.876 |
ULK2 |
0.814 | -0.033 | 2 | 0.793 |
ATM |
0.814 | 0.029 | 1 | 0.764 |
RIPK3 |
0.813 | -0.108 | 3 | 0.807 |
PIM1 |
0.813 | -0.020 | -3 | 0.688 |
CDK2 |
0.813 | 0.123 | 1 | 0.790 |
CLK4 |
0.813 | 0.070 | -3 | 0.675 |
DAPK1 |
0.812 | -0.098 | -3 | 0.689 |
GRK1 |
0.812 | 0.141 | -2 | 0.761 |
PLK2 |
0.812 | 0.105 | -3 | 0.837 |
ROCK1 |
0.812 | -0.064 | -3 | 0.652 |
MTOR |
0.812 | -0.057 | 1 | 0.800 |
MASTL |
0.811 | -0.364 | -2 | 0.782 |
RIPK1 |
0.811 | -0.278 | 1 | 0.809 |
PIM3 |
0.810 | -0.034 | -3 | 0.744 |
IRE1 |
0.809 | -0.011 | 1 | 0.816 |
CDK6 |
0.809 | 0.120 | 1 | 0.714 |
DYRK2 |
0.809 | 0.076 | 1 | 0.810 |
AMPKA1 |
0.809 | -0.108 | -3 | 0.767 |
DNAPK |
0.808 | -0.041 | 1 | 0.678 |
MRCKA |
0.808 | -0.060 | -3 | 0.654 |
NUAK2 |
0.808 | -0.076 | -3 | 0.756 |
DCAMKL1 |
0.808 | -0.089 | -3 | 0.691 |
P70S6KB |
0.808 | -0.067 | -3 | 0.701 |
PIM2 |
0.807 | -0.055 | -3 | 0.647 |
CDKL5 |
0.807 | -0.050 | -3 | 0.697 |
GRK4 |
0.807 | 0.033 | -2 | 0.795 |
MOK |
0.807 | 0.021 | 1 | 0.822 |
PKN2 |
0.806 | -0.073 | -3 | 0.755 |
MRCKB |
0.806 | -0.061 | -3 | 0.640 |
CDK4 |
0.806 | 0.102 | 1 | 0.709 |
HUNK |
0.806 | -0.167 | 2 | 0.798 |
CDK3 |
0.806 | 0.177 | 1 | 0.670 |
GSK3A |
0.806 | 0.047 | 4 | 0.482 |
CHK1 |
0.805 | -0.124 | -3 | 0.737 |
DRAK1 |
0.805 | -0.122 | 1 | 0.700 |
TBK1 |
0.805 | -0.099 | 1 | 0.694 |
SMG1 |
0.805 | -0.084 | 1 | 0.769 |
HIPK3 |
0.804 | 0.025 | 1 | 0.805 |
GSK3B |
0.804 | -0.017 | 4 | 0.469 |
CDK14 |
0.804 | 0.091 | 1 | 0.733 |
WNK3 |
0.804 | -0.228 | 1 | 0.802 |
DCAMKL2 |
0.803 | -0.104 | -3 | 0.723 |
IKKB |
0.802 | -0.008 | -2 | 0.770 |
MAK |
0.802 | 0.014 | -2 | 0.610 |
CRIK |
0.801 | -0.089 | -3 | 0.598 |
DYRK1A |
0.801 | 0.011 | 1 | 0.828 |
TTBK2 |
0.801 | -0.137 | 2 | 0.706 |
MARK4 |
0.801 | -0.103 | 4 | 0.809 |
SRPK3 |
0.801 | 0.019 | -3 | 0.628 |
IKKE |
0.801 | -0.087 | 1 | 0.694 |
CDK13 |
0.801 | 0.098 | 1 | 0.738 |
CDK16 |
0.801 | 0.152 | 1 | 0.671 |
CLK1 |
0.801 | 0.080 | -3 | 0.655 |
PKCH |
0.800 | -0.034 | 2 | 0.756 |
GCN2 |
0.800 | 0.029 | 2 | 0.809 |
IRAK1 |
0.800 | -0.260 | -1 | 0.724 |
SRPK1 |
0.800 | 0.051 | -3 | 0.653 |
ULK1 |
0.799 | -0.046 | -3 | 0.792 |
CDK17 |
0.799 | 0.119 | 1 | 0.655 |
TSSK1 |
0.799 | -0.110 | -3 | 0.785 |
HIPK4 |
0.799 | 0.012 | 1 | 0.881 |
PKCA |
0.799 | -0.019 | 2 | 0.762 |
CDK8 |
0.798 | 0.101 | 1 | 0.757 |
PKCZ |
0.798 | -0.068 | 2 | 0.792 |
RIPK2 |
0.797 | -0.229 | 1 | 0.722 |
DYRK3 |
0.797 | 0.028 | 1 | 0.830 |
IKKA |
0.797 | 0.088 | -2 | 0.757 |
AKT2 |
0.796 | -0.053 | -3 | 0.588 |
STK33 |
0.796 | -0.132 | 2 | 0.612 |
MYLK4 |
0.796 | -0.114 | -2 | 0.697 |
DYRK1B |
0.796 | 0.053 | 1 | 0.755 |
AMPKA2 |
0.795 | -0.108 | -3 | 0.729 |
PAK2 |
0.795 | -0.135 | -2 | 0.681 |
CDK12 |
0.795 | 0.084 | 1 | 0.716 |
PKCB |
0.794 | -0.006 | 2 | 0.769 |
SGK3 |
0.794 | -0.100 | -3 | 0.660 |
CAMK2D |
0.794 | -0.168 | -3 | 0.748 |
RSK2 |
0.794 | -0.050 | -3 | 0.675 |
MELK |
0.793 | -0.128 | -3 | 0.708 |
PDHK3_TYR |
0.793 | 0.088 | 4 | 0.874 |
CDK18 |
0.793 | 0.109 | 1 | 0.701 |
PAK1 |
0.793 | -0.100 | -2 | 0.682 |
CAMK2B |
0.793 | -0.032 | 2 | 0.772 |
GRK3 |
0.792 | 0.016 | -2 | 0.686 |
CAMK4 |
0.791 | -0.184 | -3 | 0.733 |
PKCG |
0.791 | -0.021 | 2 | 0.767 |
PKCE |
0.790 | -0.001 | 2 | 0.758 |
HIPK2 |
0.790 | 0.094 | 1 | 0.733 |
AKT1 |
0.790 | -0.046 | -3 | 0.602 |
CDK9 |
0.790 | 0.056 | 1 | 0.745 |
CHK2 |
0.790 | -0.108 | -3 | 0.532 |
AURB |
0.790 | -0.043 | -2 | 0.589 |
P90RSK |
0.789 | -0.102 | -3 | 0.674 |
NDR1 |
0.789 | -0.099 | -3 | 0.744 |
PKCI |
0.789 | -0.058 | 2 | 0.767 |
QIK |
0.789 | -0.171 | -3 | 0.750 |
NIM1 |
0.789 | -0.145 | 3 | 0.832 |
CLK2 |
0.788 | 0.122 | -3 | 0.652 |
CAMK1D |
0.788 | -0.116 | -3 | 0.582 |
SGK1 |
0.787 | -0.074 | -3 | 0.500 |
CDK7 |
0.787 | 0.046 | 1 | 0.760 |
MAPKAPK3 |
0.787 | -0.135 | -3 | 0.668 |
CAMK1G |
0.787 | -0.115 | -3 | 0.663 |
PLK4 |
0.787 | -0.135 | 2 | 0.636 |
DYRK4 |
0.787 | 0.074 | 1 | 0.738 |
CDK10 |
0.787 | 0.102 | 1 | 0.719 |
MAP2K6_TYR |
0.786 | 0.062 | -1 | 0.853 |
PDHK4_TYR |
0.786 | 0.043 | 2 | 0.868 |
PAK3 |
0.786 | -0.150 | -2 | 0.693 |
BMPR2_TYR |
0.786 | 0.034 | -1 | 0.847 |
PRKD3 |
0.786 | -0.100 | -3 | 0.650 |
SSTK |
0.785 | -0.107 | 4 | 0.777 |
MARK2 |
0.785 | -0.102 | 4 | 0.713 |
AURA |
0.785 | -0.026 | -2 | 0.565 |
MAP2K4_TYR |
0.785 | -0.031 | -1 | 0.848 |
PKCT |
0.785 | -0.059 | 2 | 0.761 |
CK1D |
0.785 | 0.020 | -3 | 0.532 |
CAMK2A |
0.785 | -0.068 | 2 | 0.796 |
TESK1_TYR |
0.784 | -0.071 | 3 | 0.924 |
PDHK1_TYR |
0.784 | 0.047 | -1 | 0.882 |
PINK1_TYR |
0.784 | -0.023 | 1 | 0.841 |
SRPK2 |
0.784 | 0.047 | -3 | 0.569 |
EPHA6 |
0.783 | 0.092 | -1 | 0.872 |
CK2A2 |
0.783 | 0.109 | 1 | 0.669 |
MAP2K7_TYR |
0.782 | -0.170 | 2 | 0.859 |
CDK19 |
0.782 | 0.090 | 1 | 0.720 |
PKACG |
0.782 | -0.094 | -2 | 0.678 |
RSK4 |
0.782 | -0.046 | -3 | 0.641 |
PKMYT1_TYR |
0.781 | -0.108 | 3 | 0.907 |
LATS2 |
0.781 | -0.055 | -5 | 0.727 |
BCKDK |
0.781 | -0.207 | -1 | 0.769 |
MARK1 |
0.781 | -0.131 | 4 | 0.775 |
TTBK1 |
0.780 | -0.145 | 2 | 0.627 |
RSK3 |
0.780 | -0.092 | -3 | 0.669 |
QSK |
0.780 | -0.111 | 4 | 0.792 |
MARK3 |
0.779 | -0.083 | 4 | 0.758 |
PKG2 |
0.779 | -0.074 | -2 | 0.607 |
PHKG1 |
0.779 | -0.071 | -3 | 0.732 |
FAM20C |
0.778 | 0.094 | 2 | 0.603 |
KIS |
0.778 | 0.169 | 1 | 0.787 |
LIMK2_TYR |
0.778 | -0.061 | -3 | 0.827 |
ABL2 |
0.778 | 0.075 | -1 | 0.836 |
RET |
0.778 | -0.063 | 1 | 0.811 |
NUAK1 |
0.777 | -0.101 | -3 | 0.697 |
EPHB4 |
0.777 | 0.043 | -1 | 0.857 |
MNK1 |
0.777 | -0.088 | -2 | 0.718 |
TYK2 |
0.777 | -0.070 | 1 | 0.805 |
P70S6K |
0.776 | -0.115 | -3 | 0.600 |
CK1A2 |
0.776 | -0.001 | -3 | 0.527 |
NDR2 |
0.776 | -0.066 | -3 | 0.754 |
MSK2 |
0.776 | -0.127 | -3 | 0.637 |
MNK2 |
0.776 | -0.102 | -2 | 0.709 |
PRKD1 |
0.775 | -0.129 | -3 | 0.725 |
MSK1 |
0.775 | -0.105 | -3 | 0.639 |
CSF1R |
0.775 | 0.005 | 3 | 0.859 |
FER |
0.775 | 0.051 | 1 | 0.842 |
JAK2 |
0.775 | -0.051 | 1 | 0.803 |
PRKD2 |
0.775 | -0.072 | -3 | 0.672 |
TXK |
0.775 | 0.119 | 1 | 0.781 |
CAMK1A |
0.774 | -0.115 | -3 | 0.557 |
MST1R |
0.774 | -0.103 | 3 | 0.878 |
ROS1 |
0.774 | -0.023 | 3 | 0.849 |
AURC |
0.773 | -0.025 | -2 | 0.585 |
YES1 |
0.773 | 0.042 | -1 | 0.818 |
BLK |
0.773 | 0.153 | -1 | 0.835 |
CK2A1 |
0.773 | 0.067 | 1 | 0.642 |
TYRO3 |
0.773 | -0.063 | 3 | 0.869 |
SBK |
0.773 | -0.098 | -3 | 0.463 |
MAPKAPK2 |
0.772 | -0.068 | -3 | 0.622 |
LCK |
0.772 | 0.111 | -1 | 0.819 |
LIMK1_TYR |
0.772 | -0.176 | 2 | 0.860 |
ABL1 |
0.772 | 0.030 | -1 | 0.824 |
SIK |
0.772 | -0.114 | -3 | 0.664 |
JAK3 |
0.772 | -0.008 | 1 | 0.787 |
EPHA4 |
0.772 | 0.046 | 2 | 0.754 |
PKACB |
0.772 | -0.043 | -2 | 0.604 |
HCK |
0.772 | 0.046 | -1 | 0.816 |
INSRR |
0.771 | 0.020 | 3 | 0.814 |
FLT3 |
0.771 | -0.003 | 3 | 0.859 |
KIT |
0.771 | 0.004 | 3 | 0.860 |
CK1E |
0.771 | -0.000 | -3 | 0.581 |
FGR |
0.770 | -0.008 | 1 | 0.792 |
EPHB1 |
0.770 | 0.027 | 1 | 0.825 |
SNRK |
0.770 | -0.220 | 2 | 0.692 |
EPHB2 |
0.770 | 0.078 | -1 | 0.851 |
SRMS |
0.769 | 0.024 | 1 | 0.826 |
PAK6 |
0.769 | -0.030 | -2 | 0.646 |
KDR |
0.768 | -0.003 | 3 | 0.815 |
FGFR2 |
0.768 | -0.030 | 3 | 0.844 |
EPHB3 |
0.768 | 0.022 | -1 | 0.848 |
YANK3 |
0.768 | -0.081 | 2 | 0.393 |
TEC |
0.767 | 0.058 | -1 | 0.752 |
FLT1 |
0.767 | 0.041 | -1 | 0.864 |
ITK |
0.767 | 0.014 | -1 | 0.795 |
PDGFRB |
0.767 | -0.066 | 3 | 0.870 |
FRK |
0.766 | 0.091 | -1 | 0.867 |
DDR1 |
0.766 | -0.193 | 4 | 0.790 |
AKT3 |
0.765 | -0.060 | -3 | 0.518 |
TEK |
0.765 | -0.044 | 3 | 0.808 |
WEE1_TYR |
0.765 | -0.020 | -1 | 0.734 |
PKN1 |
0.764 | -0.108 | -3 | 0.619 |
PHKG2 |
0.764 | -0.087 | -3 | 0.714 |
FYN |
0.763 | 0.081 | -1 | 0.781 |
MAPKAPK5 |
0.763 | -0.202 | -3 | 0.599 |
MET |
0.763 | -0.027 | 3 | 0.845 |
YANK2 |
0.762 | -0.085 | 2 | 0.409 |
BMX |
0.762 | 0.000 | -1 | 0.737 |
FGFR1 |
0.762 | -0.072 | 3 | 0.829 |
EPHA7 |
0.762 | 0.015 | 2 | 0.758 |
TNNI3K_TYR |
0.762 | -0.034 | 1 | 0.827 |
BTK |
0.762 | -0.066 | -1 | 0.764 |
MATK |
0.761 | 0.002 | -1 | 0.784 |
LTK |
0.761 | -0.047 | 3 | 0.819 |
ERBB2 |
0.761 | -0.045 | 1 | 0.767 |
JAK1 |
0.760 | -0.066 | 1 | 0.734 |
ALK |
0.760 | -0.053 | 3 | 0.801 |
PKACA |
0.760 | -0.071 | -2 | 0.558 |
PTK6 |
0.760 | -0.083 | -1 | 0.725 |
LYN |
0.760 | 0.041 | 3 | 0.795 |
FGFR3 |
0.760 | -0.025 | 3 | 0.816 |
MERTK |
0.759 | -0.060 | 3 | 0.830 |
NEK10_TYR |
0.759 | -0.120 | 1 | 0.675 |
FLT4 |
0.758 | -0.053 | 3 | 0.810 |
TNK2 |
0.758 | -0.129 | 3 | 0.808 |
PDGFRA |
0.758 | -0.163 | 3 | 0.872 |
EPHA5 |
0.757 | 0.043 | 2 | 0.737 |
SYK |
0.757 | 0.105 | -1 | 0.796 |
BRSK2 |
0.757 | -0.193 | -3 | 0.721 |
EGFR |
0.756 | 0.020 | 1 | 0.685 |
NTRK1 |
0.756 | -0.113 | -1 | 0.820 |
EPHA8 |
0.756 | 0.032 | -1 | 0.835 |
PRKX |
0.755 | -0.002 | -3 | 0.579 |
TNK1 |
0.755 | -0.154 | 3 | 0.847 |
AXL |
0.755 | -0.145 | 3 | 0.835 |
EPHA3 |
0.755 | -0.088 | 2 | 0.733 |
BRSK1 |
0.755 | -0.164 | -3 | 0.694 |
NTRK2 |
0.754 | -0.106 | 3 | 0.817 |
SRC |
0.752 | 0.005 | -1 | 0.785 |
INSR |
0.751 | -0.101 | 3 | 0.799 |
FGFR4 |
0.750 | -0.012 | -1 | 0.804 |
NTRK3 |
0.750 | -0.082 | -1 | 0.779 |
EPHA1 |
0.750 | -0.107 | 3 | 0.826 |
CSK |
0.749 | -0.075 | 2 | 0.766 |
PTK2B |
0.749 | -0.048 | -1 | 0.774 |
PAK5 |
0.748 | -0.106 | -2 | 0.569 |
PTK2 |
0.748 | 0.015 | -1 | 0.773 |
MUSK |
0.747 | -0.038 | 1 | 0.669 |
EPHA2 |
0.747 | 0.016 | -1 | 0.811 |
DDR2 |
0.744 | -0.110 | 3 | 0.802 |
CK1G3 |
0.742 | -0.004 | -3 | 0.406 |
ERBB4 |
0.742 | 0.009 | 1 | 0.690 |
IGF1R |
0.741 | -0.058 | 3 | 0.744 |
CK1G1 |
0.739 | -0.040 | -3 | 0.576 |
PAK4 |
0.739 | -0.091 | -2 | 0.573 |
PKG1 |
0.730 | -0.129 | -2 | 0.524 |
ZAP70 |
0.727 | -0.005 | -1 | 0.699 |
CK1G2 |
0.725 | 0.019 | -3 | 0.498 |
FES |
0.725 | -0.108 | -1 | 0.708 |
CK1A |
0.710 | -0.022 | -3 | 0.452 |