Motif 1056 (n=92)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | T979 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NNZ2 | TUBB8B | T274 | ochoa | Tubulin beta 8B | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| O00151 | PDLIM1 | T287 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O14715 | RGPD8 | T978 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14939 | PLD2 | T100 | psp | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}. |
| O14983 | ATP2A1 | T358 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677). {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}. |
| O15264 | MAPK13 | T185 | ochoa | Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212, ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148, ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666, ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}. |
| O94903 | PLPBP | T245 | ochoa | Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (Proline synthase co-transcribed bacterial homolog protein) (Pyridoxal phosphate-binding protein) | Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. {ECO:0000255|HAMAP-Rule:MF_03225, ECO:0000269|PubMed:27912044}. |
| P04350 | TUBB4A | T274 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07437 | TUBB | T274 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DJD0 | RGPD1 | T963 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T971 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DPH7 | TUBA3C | T334 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T334 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P16615 | ATP2A2 | T358 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}. |
| P21709 | EPHA1 | T783 | ochoa | Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}. |
| P29317 | EPHA2 | T774 | ochoa | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P29320 | EPHA3 | T781 | ochoa | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
| P29323 | EPHB2 | T781 | ochoa | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}. |
| P32780 | GTF2H1 | T74 | psp | General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:9852112}. |
| P49792 | RANBP2 | T1954 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P51003 | PAPOLA | T109 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P51798 | CLCN7 | T27 | ochoa | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) | Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}. |
| P52597 | HNRNPF | T238 | ochoa | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}. |
| P53778 | MAPK12 | T188 | ochoa | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}. |
| P54753 | EPHB3 | T793 | ochoa | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:15536074}. |
| P54756 | EPHA5 | T835 | ochoa | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}. |
| P54760 | EPHB4 | T775 | ochoa | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904, ECO:0000269|PubMed:27400125, ECO:0000269|PubMed:30578106}. |
| P54764 | EPHA4 | T781 | ochoa | Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) | Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (By similarity). {ECO:0000250|UniProtKB:Q03137, ECO:0000269|PubMed:17143272}. |
| P68363 | TUBA1B | T334 | ochoa|psp | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68371 | TUBB4B | T274 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78344 | EIF4G2 | T385 | ochoa | Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97) | Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}. |
| P78347 | GTF2I | T413 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78362 | SRPK2 | T547 | ochoa | SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). {ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21056976, ECO:0000269|PubMed:21205200, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9472028}. |
| Q12888 | TP53BP1 | T1450 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13362 | PPP2R5C | T385 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}. |
| Q13761 | RUNX3 | T173 | psp | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250|UniProtKB:Q64131, ECO:0000269|PubMed:20599712}. |
| Q13772 | NCOA4 | T307 | ochoa | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ferritin cargo receptor NCOA4) (Ret-activating protein ELE1) | Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}. |
| Q13885 | TUBB2A | T274 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q14653 | IRF3 | T333 | ochoa | Interferon regulatory factor 3 (IRF-3) | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:24049179, PubMed:25636800, PubMed:27302953, PubMed:31340999, PubMed:36603579, PubMed:8524823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995, PubMed:36603579, PubMed:8524823). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:36603579). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:36603579). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148, PubMed:36603579). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:24049179, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31340999, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:36603579, ECO:0000269|PubMed:8524823, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
| Q14676 | MDC1 | T654 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14738 | PPP2R5D | T461 | ochoa | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Q16539 | MAPK14 | T185 | ochoa|psp | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:9430721, PubMed:9858528). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}. |
| Q3V6T2 | CCDC88A | T1816 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q3ZCM7 | TUBB8 | T274 | ochoa | Tubulin beta-8 chain (Tubulin beta 8 class VIII) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376). {ECO:0000269|PubMed:26789871, ECO:0000269|PubMed:34509376}. |
| Q5JVS0 | HABP4 | T354 | psp | Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature oocyte by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also binds RNA, regulating transcription and pre-mRNA splicing (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). {ECO:0000250|UniProtKB:A1L1K8, ECO:0000250|UniProtKB:Q5XJA5, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:28695742}. |
| Q6PEY2 | TUBA3E | T334 | ochoa | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q71U36 | TUBA1A | T334 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z3J3 | RGPD4 | T979 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z6Z7 | HUWE1 | T1344 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86WX3 | RPS19BP1 | T85 | ochoa | Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed:34516797). Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed:17964266). {ECO:0000269|PubMed:17964266, ECO:0000269|PubMed:34516797}. |
| Q8IW41 | MAPKAPK5 | T186 | ochoa | MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}. |
| Q8IWZ3 | ANKHD1 | T86 | ochoa | Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) | May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}. |
| Q8N4S9 | MARVELD2 | T168 | ochoa | MARVEL domain-containing protein 2 (Tricellulin) | Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). {ECO:0000250|UniProtKB:Q3UZP0, ECO:0000269|PubMed:17186462}. |
| Q8TB72 | PUM2 | T175 | ochoa | Pumilio homolog 2 (Pumilio-2) | Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:18776931, ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517, ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866, ECO:0000269|PubMed:28431233}. |
| Q93084 | ATP2A3 | T358 | ochoa | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}. |
| Q96IQ7 | VSIG2 | T277 | ochoa | V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein) | None |
| Q96K80 | ZC3H10 | T173 | ochoa | Zinc finger CCCH domain-containing protein 10 | Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA. {ECO:0000269|PubMed:28431233}. |
| Q96QT6 | PHF12 | T536 | ochoa | PHD finger protein 12 (PHD factor 1) (Pf1) | Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity). {ECO:0000250|UniProtKB:Q5SPL2, ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:21041482, ECO:0000269|PubMed:37137925}. |
| Q96SB4 | SRPK1 | T514 | ochoa | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation. {ECO:0000269|PubMed:10049757, ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:12134018, ECO:0000269|PubMed:14555757, ECO:0000269|PubMed:15034300, ECO:0000269|PubMed:16122776, ECO:0000269|PubMed:16209947, ECO:0000269|PubMed:18155240, ECO:0000269|PubMed:18687337, ECO:0000269|PubMed:19240134, ECO:0000269|PubMed:19477182, ECO:0000269|PubMed:19886675, ECO:0000269|PubMed:20708644, ECO:0000269|PubMed:8208298, ECO:0000269|PubMed:9237760}. |
| Q99666 | RGPD5 | T978 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQE3 | TUBA1C | T334 | ochoa | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9BUF5 | TUBB6 | T274 | ochoa | Tubulin beta-6 chain (Tubulin beta class V) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. {ECO:0000250|UniProtKB:P02557}. |
| Q9BVA1 | TUBB2B | T274 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BWT3 | PAPOLG | T108 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9H7E2 | TDRD3 | T84 | ochoa | Tudor domain-containing protein 3 | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins (PubMed:15955813). Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci (PubMed:21172665). In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1 (PubMed:35085371). {ECO:0000269|PubMed:15955813, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:21172665, ECO:0000269|PubMed:35085371}. |
| Q9NP74 | PALMD | T527 | ochoa | Palmdelphin (Paralemmin-like protein) | None |
| Q9NWZ3 | IRAK4 | S346 | psp | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}. |
| Q9UHD2 | TBK1 | Y174 | psp | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:11839743, PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:15485837, PubMed:18583960, PubMed:21138416, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:25636800, PubMed:26611359, PubMed:32404352, PubMed:34363755, PubMed:32298923). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:12702806, PubMed:14703513, PubMed:15367631, PubMed:18583960, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653, PubMed:37926288). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (By similarity). Phosphorylates and activates AKT1 (PubMed:21464307). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (PubMed:34363755). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (PubMed:27135603). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32298923, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:34363755, ECO:0000269|PubMed:37926288}. |
| Q9UKX2 | MYH2 | T792 | ochoa | Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. {ECO:0000250|UniProtKB:P12883}. |
| Q9UPE1 | SRPK3 | T426 | ochoa | SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23) | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). {ECO:0000250|UniProtKB:Q9Z0G2}. |
| Q9Y2W1 | THRAP3 | T397 | ochoa | Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}. |
| Q14498 | RBM39 | T175 | Sugiyama | RNA-binding protein 39 (CAPER alpha) (CAPERalpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1) | RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}. |
| Q9Y3F4 | STRAP | T54 | Sugiyama | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}. |
| P25205 | MCM3 | T368 | Sugiyama | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P49327 | FASN | T217 | Sugiyama | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| O60739 | EIF1B | T46 | Sugiyama | Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20) | Probably involved in translation. |
| P41567 | EIF1 | T46 | Sugiyama | Eukaryotic translation initiation factor 1 (eIF1) (A121) (Protein translation factor SUI1 homolog) (Sui1iso1) | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:12435632, PubMed:14600024, PubMed:9732867). Together with eIF1A (EIF1AX), EIF1 facilitates scanning and is essential for start codon recognition on the basis of AUG nucleotide context and location relative to the 5'-cap (PubMed:12435632, PubMed:14600024, PubMed:9732867). Participates to initiation codon selection by influencing the conformation of the 40S ribosomal subunit and the positions of bound mRNA and initiator tRNA; this is possible after its binding to the interface surface of the platform of the 40S ribosomal subunit close to the P-site (PubMed:14600024). Together with eIF1A (EIF1AX), also regulates the opening and closing of the mRNA binding channel, which ensures mRNA recruitment, scanning and the fidelity of initiation codon selection (PubMed:9732867). Continuously monitors and protects against premature and partial base-pairing of codons in the 5'-UTR with the anticodon of initiator tRNA (PubMed:12435632, PubMed:9732867). Together with eIF1A (EIF1AX), acts for ribosomal scanning, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubMed:9732867). Interacts with EIF4G1, which in a mutual exclusive interaction associates either with EIF1 or with EIF4E on a common binding site (PubMed:29987188). EIF4G1-EIF1 complex promotes ribosome scanning (on both short and long 5'UTR), leaky scanning (on short 5'UTR) which is the bypass of the initial start codon, and discrimination against cap-proximal AUG (PubMed:29987188). Is probably maintained within the 43S PIC in open conformation thanks to eIF1A-EIF5 interaction (PubMed:24319994). Once the correct start codon is reached, EIF1 is physically excluded from the decoding site, shifting the PIC into the closed conformation and arresting it at the start codon (PubMed:22813744). {ECO:0000269|PubMed:12435632, ECO:0000269|PubMed:14600024, ECO:0000269|PubMed:22813744, ECO:0000269|PubMed:29987188, ECO:0000269|PubMed:9732867}. |
| P29597 | TYK2 | T919 | Sugiyama | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552}. |
| P41743 | PRKCI | T142 | Sugiyama | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). {ECO:0000250|UniProtKB:F1M7Y5, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10467349, ECO:0000269|PubMed:10906326, ECO:0000269|PubMed:11042363, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:12871960, ECO:0000269|PubMed:14684752, ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19327373, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21419810, ECO:0000269|PubMed:8226978, ECO:0000269|PubMed:9346882}. |
| P62753 | RPS6 | T26 | Sugiyama | Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33) | Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:17220279, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:8706699}. |
| Q14697 | GANAB | T492 | Sugiyama | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:27259053}. |
| P24864 | CCNE1 | T36 | Sugiyama | G1/S-specific cyclin-E1 | Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}. |
| Q13043 | STK4 | T273 | Sugiyama | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. |
| P62280 | RPS11 | T127 | Sugiyama | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Q9HB07 | MYG1 | T193 | Sugiyama | MYG1 exonuclease (EC 3.1.-.-) | 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}. |
| Q14164 | IKBKE | Y174 | Sugiyama | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' also seems to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}. |
| Q15375 | EPHA7 | T793 | Sugiyama | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. |
| Q15759 | MAPK11 | T185 | Sugiyama | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:15356147, PubMed:9430721). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:10330143, PubMed:15356147, PubMed:9430721). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (PubMed:38270553). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:38270553, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}. |
| Q5S007 | LRRK2 | T1404 | SIGNOR|EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| O15067 | PFAS | T591 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| Q10713 | PMPCA | T294 | Sugiyama | Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) | Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. {ECO:0000269|PubMed:25808372}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 1.110223e-16 | 15.955 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.110223e-16 | 15.955 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.110223e-16 | 15.955 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.110223e-16 | 15.955 |
| R-HSA-9646399 | Aggrephagy | 1.110223e-16 | 15.955 |
| R-HSA-190861 | Gap junction assembly | 1.110223e-16 | 15.955 |
| R-HSA-190828 | Gap junction trafficking | 1.110223e-16 | 15.955 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 1.110223e-16 | 15.955 |
| R-HSA-437239 | Recycling pathway of L1 | 1.110223e-16 | 15.955 |
| R-HSA-157858 | Gap junction trafficking and regulation | 1.110223e-16 | 15.955 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.110223e-16 | 15.955 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.220446e-16 | 15.654 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.220446e-16 | 15.654 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 5.551115e-16 | 15.256 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 8.881784e-16 | 15.051 |
| R-HSA-983189 | Kinesins | 1.332268e-15 | 14.875 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.887379e-15 | 14.724 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 1.887379e-15 | 14.724 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 2.109424e-15 | 14.676 |
| R-HSA-422475 | Axon guidance | 3.108624e-15 | 14.507 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.551914e-15 | 14.342 |
| R-HSA-9663891 | Selective autophagy | 4.551914e-15 | 14.342 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.329071e-15 | 14.273 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 8.770762e-15 | 14.057 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 1.199041e-14 | 13.921 |
| R-HSA-9675108 | Nervous system development | 1.343370e-14 | 13.872 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.386180e-14 | 13.470 |
| R-HSA-9833482 | PKR-mediated signaling | 3.386180e-14 | 13.470 |
| R-HSA-68877 | Mitotic Prometaphase | 5.850875e-14 | 13.233 |
| R-HSA-2467813 | Separation of Sister Chromatids | 8.582024e-14 | 13.066 |
| R-HSA-438064 | Post NMDA receptor activation events | 1.006972e-13 | 12.997 |
| R-HSA-373760 | L1CAM interactions | 2.304823e-13 | 12.637 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 3.892442e-13 | 12.410 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 3.892442e-13 | 12.410 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 5.124789e-13 | 12.290 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 7.662759e-13 | 12.116 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 2.356337e-12 | 11.628 |
| R-HSA-1632852 | Macroautophagy | 3.049450e-12 | 11.516 |
| R-HSA-68882 | Mitotic Anaphase | 4.131362e-12 | 11.384 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.397371e-12 | 11.357 |
| R-HSA-391251 | Protein folding | 4.723444e-12 | 11.326 |
| R-HSA-5620924 | Intraflagellar transport | 5.526579e-12 | 11.258 |
| R-HSA-2132295 | MHC class II antigen presentation | 8.245626e-12 | 11.084 |
| R-HSA-9612973 | Autophagy | 1.081069e-11 | 10.966 |
| R-HSA-913531 | Interferon Signaling | 1.803679e-11 | 10.744 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 2.122325e-11 | 10.673 |
| R-HSA-1640170 | Cell Cycle | 4.568734e-11 | 10.340 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 7.968082e-11 | 10.099 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 9.221168e-11 | 10.035 |
| R-HSA-69275 | G2/M Transition | 9.104595e-11 | 10.041 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.031999e-10 | 9.986 |
| R-HSA-5617833 | Cilium Assembly | 1.168233e-10 | 9.932 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.415108e-10 | 9.849 |
| R-HSA-9609690 | HCMV Early Events | 1.681822e-10 | 9.774 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.601735e-10 | 9.252 |
| R-HSA-68886 | M Phase | 1.192458e-09 | 8.924 |
| R-HSA-69278 | Cell Cycle, Mitotic | 1.359236e-09 | 8.867 |
| R-HSA-2682334 | EPH-Ephrin signaling | 1.735187e-09 | 8.761 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 2.369918e-09 | 8.625 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 2.638898e-09 | 8.579 |
| R-HSA-9609646 | HCMV Infection | 3.046146e-09 | 8.516 |
| R-HSA-5610787 | Hedgehog 'off' state | 3.851139e-09 | 8.414 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 4.679074e-09 | 8.330 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 6.435989e-09 | 8.191 |
| R-HSA-1266738 | Developmental Biology | 1.453841e-08 | 7.837 |
| R-HSA-162582 | Signal Transduction | 5.058236e-08 | 7.296 |
| R-HSA-9824446 | Viral Infection Pathways | 7.243605e-08 | 7.140 |
| R-HSA-5358351 | Signaling by Hedgehog | 8.571642e-08 | 7.067 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 1.001935e-07 | 6.999 |
| R-HSA-109582 | Hemostasis | 2.426764e-07 | 6.615 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.167398e-07 | 6.380 |
| R-HSA-2262752 | Cellular responses to stress | 8.287455e-07 | 6.082 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.240438e-06 | 5.906 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.495820e-06 | 5.825 |
| R-HSA-171007 | p38MAPK events | 8.423539e-06 | 5.075 |
| R-HSA-5663205 | Infectious disease | 1.056232e-05 | 4.976 |
| R-HSA-3928664 | Ephrin signaling | 1.772982e-05 | 4.751 |
| R-HSA-112316 | Neuronal System | 1.914434e-05 | 4.718 |
| R-HSA-167044 | Signalling to RAS | 2.852164e-05 | 4.545 |
| R-HSA-168256 | Immune System | 5.511755e-05 | 4.259 |
| R-HSA-69620 | Cell Cycle Checkpoints | 9.216927e-05 | 4.035 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 9.273501e-05 | 4.033 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 1.166291e-04 | 3.933 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.280891e-04 | 3.892 |
| R-HSA-418346 | Platelet homeostasis | 1.340966e-04 | 3.873 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.411161e-04 | 3.850 |
| R-HSA-418359 | Reduction of cytosolic Ca++ levels | 1.411161e-04 | 3.850 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 1.587810e-04 | 3.799 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 1.603986e-04 | 3.795 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 1.603986e-04 | 3.795 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 1.636465e-04 | 3.786 |
| R-HSA-187687 | Signalling to ERKs | 1.793098e-04 | 3.746 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 3.763933e-04 | 3.424 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 3.763933e-04 | 3.424 |
| R-HSA-199991 | Membrane Trafficking | 4.277476e-04 | 3.369 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.792674e-04 | 3.319 |
| R-HSA-432142 | Platelet sensitization by LDL | 4.898531e-04 | 3.310 |
| R-HSA-1280218 | Adaptive Immune System | 5.421273e-04 | 3.266 |
| R-HSA-1912420 | Pre-NOTCH Processing in Golgi | 5.539442e-04 | 3.257 |
| R-HSA-198753 | ERK/MAPK targets | 6.976764e-04 | 3.156 |
| R-HSA-1606341 | IRF3 mediated activation of type 1 IFN | 1.001460e-03 | 2.999 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.111921e-03 | 2.954 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 1.256489e-03 | 2.901 |
| R-HSA-525793 | Myogenesis | 1.264453e-03 | 2.898 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.267755e-03 | 2.897 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.267755e-03 | 2.897 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.473909e-03 | 2.832 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 1.631264e-03 | 2.787 |
| R-HSA-418360 | Platelet calcium homeostasis | 1.631264e-03 | 2.787 |
| R-HSA-9679506 | SARS-CoV Infections | 1.385811e-03 | 2.858 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 1.334070e-03 | 2.875 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 1.641408e-03 | 2.785 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.781621e-03 | 2.749 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 1.909148e-03 | 2.719 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.043754e-03 | 2.690 |
| R-HSA-1643685 | Disease | 2.084303e-03 | 2.681 |
| R-HSA-380287 | Centrosome maturation | 2.231017e-03 | 2.651 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.231017e-03 | 2.651 |
| R-HSA-194138 | Signaling by VEGF | 2.336387e-03 | 2.631 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 2.431353e-03 | 2.614 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.533613e-03 | 2.596 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 2.558269e-03 | 2.592 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 2.881268e-03 | 2.540 |
| R-HSA-5653656 | Vesicle-mediated transport | 2.934253e-03 | 2.533 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 3.888633e-03 | 2.410 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 3.888633e-03 | 2.410 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 3.888633e-03 | 2.410 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 3.106786e-03 | 2.508 |
| R-HSA-4839744 | Signaling by APC mutants | 3.888633e-03 | 2.410 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.221222e-03 | 2.492 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 4.114282e-03 | 2.386 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 3.888633e-03 | 2.410 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 4.172582e-03 | 2.380 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 4.191391e-03 | 2.378 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 4.445132e-03 | 2.352 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 4.445132e-03 | 2.352 |
| R-HSA-4839735 | Signaling by AXIN mutants | 4.445132e-03 | 2.352 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 4.445132e-03 | 2.352 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 4.625130e-03 | 2.335 |
| R-HSA-166520 | Signaling by NTRKs | 4.797264e-03 | 2.319 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.939434e-03 | 2.306 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 5.036215e-03 | 2.298 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 5.036215e-03 | 2.298 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 5.036215e-03 | 2.298 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 5.036215e-03 | 2.298 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 5.036215e-03 | 2.298 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 5.661418e-03 | 2.247 |
| R-HSA-597592 | Post-translational protein modification | 5.753773e-03 | 2.240 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.836715e-03 | 2.234 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.836715e-03 | 2.234 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.836715e-03 | 2.234 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 7.012348e-03 | 2.154 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 7.012348e-03 | 2.154 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 7.309250e-03 | 2.136 |
| R-HSA-72649 | Translation initiation complex formation | 7.989841e-03 | 2.097 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 8.706616e-03 | 2.060 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 9.459978e-03 | 2.024 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.010371e-02 | 1.996 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 8.494298e-03 | 2.071 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 1.095512e-02 | 1.960 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 8.355577e-03 | 2.078 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.149938e-02 | 1.939 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.149938e-02 | 1.939 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.045646e-02 | 1.981 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 9.331380e-03 | 2.030 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 1.011005e-02 | 1.995 |
| R-HSA-450604 | KSRP (KHSRP) binds and destabilizes mRNA | 7.737170e-03 | 2.111 |
| R-HSA-450294 | MAP kinase activation | 1.065942e-02 | 1.972 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 8.494298e-03 | 2.071 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 8.122567e-03 | 2.090 |
| R-HSA-9694631 | Maturation of nucleoprotein | 1.095512e-02 | 1.960 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.150578e-02 | 1.939 |
| R-HSA-5578775 | Ion homeostasis | 8.706616e-03 | 2.060 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 9.331380e-03 | 2.030 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 1.183710e-02 | 1.927 |
| R-HSA-936837 | Ion transport by P-type ATPases | 1.194310e-02 | 1.923 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.238914e-02 | 1.907 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.238914e-02 | 1.907 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 1.274921e-02 | 1.895 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.369104e-02 | 1.864 |
| R-HSA-166208 | mTORC1-mediated signalling | 1.466217e-02 | 1.834 |
| R-HSA-448424 | Interleukin-17 signaling | 1.476680e-02 | 1.831 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.578478e-02 | 1.802 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 1.578478e-02 | 1.802 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.793683e-02 | 1.746 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.849912e-02 | 1.733 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 1.994299e-02 | 1.700 |
| R-HSA-392499 | Metabolism of proteins | 2.266997e-02 | 1.645 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 2.334839e-02 | 1.632 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 2.399848e-02 | 1.620 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 2.399848e-02 | 1.620 |
| R-HSA-8953854 | Metabolism of RNA | 2.408206e-02 | 1.618 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 2.465396e-02 | 1.608 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 2.465833e-02 | 1.608 |
| R-HSA-447115 | Interleukin-12 family signaling | 2.532794e-02 | 1.596 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 2.574805e-02 | 1.589 |
| R-HSA-4791275 | Signaling by WNT in cancer | 2.589602e-02 | 1.587 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 2.882214e-02 | 1.540 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 2.955016e-02 | 1.529 |
| R-HSA-5633007 | Regulation of TP53 Activity | 2.962297e-02 | 1.528 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 2.977056e-02 | 1.526 |
| R-HSA-5673000 | RAF activation | 2.977056e-02 | 1.526 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 3.179233e-02 | 1.498 |
| R-HSA-5603037 | IRAK4 deficiency (TLR5) | 3.208178e-02 | 1.494 |
| R-HSA-3249367 | STAT6-mediated induction of chemokines | 3.208178e-02 | 1.494 |
| R-HSA-69205 | G1/S-Specific Transcription | 3.247356e-02 | 1.488 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 3.526918e-02 | 1.453 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.653685e-02 | 1.437 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 3.819489e-02 | 1.418 |
| R-HSA-8952158 | RUNX3 regulates BCL2L11 (BIM) transcription | 3.837473e-02 | 1.416 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 3.837473e-02 | 1.416 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 3.963018e-02 | 1.402 |
| R-HSA-2559583 | Cellular Senescence | 4.180152e-02 | 1.379 |
| R-HSA-165159 | MTOR signalling | 4.264524e-02 | 1.370 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 4.339599e-02 | 1.363 |
| R-HSA-9700206 | Signaling by ALK in cancer | 4.339599e-02 | 1.363 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 4.429566e-02 | 1.354 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 4.429566e-02 | 1.354 |
| R-HSA-3134973 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | 4.462715e-02 | 1.350 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 5.083930e-02 | 1.294 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 5.083930e-02 | 1.294 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 6.314382e-02 | 1.200 |
| R-HSA-163767 | PP2A-mediated dephosphorylation of key metabolic factors | 6.314382e-02 | 1.200 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 4.798704e-02 | 1.319 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 4.798704e-02 | 1.319 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 5.379860e-02 | 1.269 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 6.098576e-02 | 1.215 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 5.701144e-02 | 1.244 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 5.701144e-02 | 1.244 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 5.379860e-02 | 1.269 |
| R-HSA-8951430 | RUNX3 regulates WNT signaling | 6.314382e-02 | 1.200 |
| R-HSA-909733 | Interferon alpha/beta signaling | 5.280740e-02 | 1.277 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 7.137128e-02 | 1.146 |
| R-HSA-9020933 | Interleukin-23 signaling | 6.923670e-02 | 1.160 |
| R-HSA-176974 | Unwinding of DNA | 7.529033e-02 | 1.123 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 6.971957e-02 | 1.157 |
| R-HSA-5693606 | DNA Double Strand Break Response | 8.653931e-02 | 1.063 |
| R-HSA-9020956 | Interleukin-27 signaling | 8.130496e-02 | 1.090 |
| R-HSA-69206 | G1/S Transition | 6.419701e-02 | 1.192 |
| R-HSA-112411 | MAPK1 (ERK2) activation | 7.529033e-02 | 1.123 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 8.728084e-02 | 1.059 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 4.892190e-02 | 1.310 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 5.217834e-02 | 1.283 |
| R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters | 6.314382e-02 | 1.200 |
| R-HSA-9683686 | Maturation of spike protein | 8.130496e-02 | 1.090 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 8.130496e-02 | 1.090 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 6.098576e-02 | 1.215 |
| R-HSA-449147 | Signaling by Interleukins | 6.085161e-02 | 1.216 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 6.239010e-02 | 1.205 |
| R-HSA-69481 | G2/M Checkpoints | 6.638068e-02 | 1.178 |
| R-HSA-168249 | Innate Immune System | 5.601778e-02 | 1.252 |
| R-HSA-8848021 | Signaling by PTK6 | 7.883904e-02 | 1.103 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 7.883904e-02 | 1.103 |
| R-HSA-9662834 | CD163 mediating an anti-inflammatory response | 8.728084e-02 | 1.059 |
| R-HSA-9824272 | Somitogenesis | 4.732273e-02 | 1.325 |
| R-HSA-389356 | Co-stimulation by CD28 | 5.217834e-02 | 1.283 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 4.732273e-02 | 1.325 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 4.732273e-02 | 1.325 |
| R-HSA-163685 | Integration of energy metabolism | 7.898636e-02 | 1.102 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 8.130496e-02 | 1.090 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 7.507503e-02 | 1.125 |
| R-HSA-983712 | Ion channel transport | 4.777130e-02 | 1.321 |
| R-HSA-75893 | TNF signaling | 6.593348e-02 | 1.181 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 4.892190e-02 | 1.310 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 7.883904e-02 | 1.103 |
| R-HSA-5576891 | Cardiac conduction | 7.198722e-02 | 1.143 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 8.266116e-02 | 1.083 |
| R-HSA-1592230 | Mitochondrial biogenesis | 5.479877e-02 | 1.261 |
| R-HSA-157118 | Signaling by NOTCH | 9.090290e-02 | 1.041 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 9.245705e-02 | 1.034 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 9.245705e-02 | 1.034 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 9.255355e-02 | 1.034 |
| R-HSA-202670 | ERKs are inactivated | 9.321821e-02 | 1.030 |
| R-HSA-9679191 | Potential therapeutics for SARS | 9.771238e-02 | 1.010 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 9.848943e-02 | 1.007 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 9.911733e-02 | 1.004 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 9.911733e-02 | 1.004 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 9.911733e-02 | 1.004 |
| R-HSA-8984722 | Interleukin-35 Signalling | 9.911733e-02 | 1.004 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 9.911733e-02 | 1.004 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.003351e-01 | 0.999 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 1.005246e-01 | 0.998 |
| R-HSA-73887 | Death Receptor Signaling | 1.029861e-01 | 0.987 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.043220e-01 | 0.982 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.049784e-01 | 0.979 |
| R-HSA-1059683 | Interleukin-6 signaling | 1.049784e-01 | 0.979 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 1.049784e-01 | 0.979 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.049784e-01 | 0.979 |
| R-HSA-8949664 | Processing of SMDT1 | 1.049784e-01 | 0.979 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 1.066996e-01 | 0.972 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 1.108721e-01 | 0.955 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 1.150870e-01 | 0.939 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 1.165876e-01 | 0.933 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.165876e-01 | 0.933 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.209040e-01 | 0.918 |
| R-HSA-9634600 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | 1.223361e-01 | 0.912 |
| R-HSA-9945266 | Differentiation of T cells | 1.223361e-01 | 0.912 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 1.223361e-01 | 0.912 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.223361e-01 | 0.912 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 1.280475e-01 | 0.893 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.280475e-01 | 0.893 |
| R-HSA-1483148 | Synthesis of PG | 1.280475e-01 | 0.893 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.321617e-01 | 0.879 |
| R-HSA-156902 | Peptide chain elongation | 1.323365e-01 | 0.878 |
| R-HSA-2028269 | Signaling by Hippo | 1.337222e-01 | 0.874 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.389509e-01 | 0.857 |
| R-HSA-168255 | Influenza Infection | 1.398225e-01 | 0.854 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.434003e-01 | 0.843 |
| R-HSA-449836 | Other interleukin signaling | 1.449620e-01 | 0.839 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 1.458452e-01 | 0.836 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 1.501304e-01 | 0.824 |
| R-HSA-9629569 | Protein hydroxylation | 1.505276e-01 | 0.822 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.522084e-01 | 0.818 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 1.523879e-01 | 0.817 |
| R-HSA-72764 | Eukaryotic Translation Termination | 1.523879e-01 | 0.817 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.615513e-01 | 0.792 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.615513e-01 | 0.792 |
| R-HSA-8949215 | Mitochondrial calcium ion transport | 1.615513e-01 | 0.792 |
| R-HSA-70171 | Glycolysis | 1.637734e-01 | 0.786 |
| R-HSA-2408557 | Selenocysteine synthesis | 1.660688e-01 | 0.780 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 1.670100e-01 | 0.777 |
| R-HSA-6803529 | FGFR2 alternative splicing | 1.670100e-01 | 0.777 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 1.670100e-01 | 0.777 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.670100e-01 | 0.777 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.683700e-01 | 0.774 |
| R-HSA-192823 | Viral mRNA Translation | 1.706768e-01 | 0.768 |
| R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | 1.724334e-01 | 0.763 |
| R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | 1.724334e-01 | 0.763 |
| R-HSA-8854691 | Interleukin-20 family signaling | 1.724334e-01 | 0.763 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 1.729889e-01 | 0.762 |
| R-HSA-9833110 | RSV-host interactions | 1.753062e-01 | 0.756 |
| R-HSA-376176 | Signaling by ROBO receptors | 1.771553e-01 | 0.752 |
| R-HSA-429947 | Deadenylation of mRNA | 1.778218e-01 | 0.750 |
| R-HSA-6783589 | Interleukin-6 family signaling | 1.778218e-01 | 0.750 |
| R-HSA-9821993 | Replacement of protamines by nucleosomes in the male pronucleus | 1.778218e-01 | 0.750 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.778218e-01 | 0.750 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 1.778218e-01 | 0.750 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 1.822879e-01 | 0.739 |
| R-HSA-69239 | Synthesis of DNA | 1.822879e-01 | 0.739 |
| R-HSA-420029 | Tight junction interactions | 1.831755e-01 | 0.737 |
| R-HSA-397014 | Muscle contraction | 1.934632e-01 | 0.713 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 1.937796e-01 | 0.713 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 1.987313e-01 | 0.702 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 1.990303e-01 | 0.701 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 1.990303e-01 | 0.701 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 1.990303e-01 | 0.701 |
| R-HSA-72086 | mRNA Capping | 2.042472e-01 | 0.690 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 2.042472e-01 | 0.690 |
| R-HSA-180024 | DARPP-32 events | 2.042472e-01 | 0.690 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.094305e-01 | 0.679 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.094305e-01 | 0.679 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 2.094305e-01 | 0.679 |
| R-HSA-9008059 | Interleukin-37 signaling | 2.094305e-01 | 0.679 |
| R-HSA-70326 | Glucose metabolism | 2.105853e-01 | 0.677 |
| R-HSA-5693538 | Homology Directed Repair | 2.129652e-01 | 0.672 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.145802e-01 | 0.668 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.145802e-01 | 0.668 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 2.196968e-01 | 0.658 |
| R-HSA-1538133 | G0 and Early G1 | 2.196968e-01 | 0.658 |
| R-HSA-69190 | DNA strand elongation | 2.196968e-01 | 0.658 |
| R-HSA-3371556 | Cellular response to heat stress | 2.201201e-01 | 0.657 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.247804e-01 | 0.648 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.247804e-01 | 0.648 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.247804e-01 | 0.648 |
| R-HSA-9930044 | Nuclear RNA decay | 2.247804e-01 | 0.648 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.298311e-01 | 0.639 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.298311e-01 | 0.639 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.298311e-01 | 0.639 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 2.298311e-01 | 0.639 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 2.298311e-01 | 0.639 |
| R-HSA-5696400 | Dual Incision in GG-NER | 2.348493e-01 | 0.629 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.348493e-01 | 0.629 |
| R-HSA-5205647 | Mitophagy | 2.348493e-01 | 0.629 |
| R-HSA-392518 | Signal amplification | 2.348493e-01 | 0.629 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 2.348493e-01 | 0.629 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.398350e-01 | 0.620 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 2.398350e-01 | 0.620 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.447886e-01 | 0.611 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 2.447886e-01 | 0.611 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.497102e-01 | 0.603 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.546000e-01 | 0.594 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.594583e-01 | 0.586 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 2.594583e-01 | 0.586 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.594583e-01 | 0.586 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 2.594583e-01 | 0.586 |
| R-HSA-421270 | Cell-cell junction organization | 2.600390e-01 | 0.585 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 2.642852e-01 | 0.578 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.642852e-01 | 0.578 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 2.642852e-01 | 0.578 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 2.642852e-01 | 0.578 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.642852e-01 | 0.578 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 2.642852e-01 | 0.578 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.642852e-01 | 0.578 |
| R-HSA-167169 | HIV Transcription Elongation | 2.642852e-01 | 0.578 |
| R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | 2.642852e-01 | 0.578 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.642852e-01 | 0.578 |
| R-HSA-5260271 | Diseases of Immune System | 2.642852e-01 | 0.578 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 2.657763e-01 | 0.575 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.681867e-01 | 0.572 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.690809e-01 | 0.570 |
| R-HSA-9694548 | Maturation of spike protein | 2.690809e-01 | 0.570 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 2.690809e-01 | 0.570 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 2.690809e-01 | 0.570 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.719647e-01 | 0.565 |
| R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | 2.738457e-01 | 0.562 |
| R-HSA-167161 | HIV Transcription Initiation | 2.738457e-01 | 0.562 |
| R-HSA-75953 | RNA Polymerase II Transcription Initiation | 2.738457e-01 | 0.562 |
| R-HSA-9683701 | Translation of Structural Proteins | 2.738457e-01 | 0.562 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 2.785797e-01 | 0.555 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 2.802362e-01 | 0.552 |
| R-HSA-73776 | RNA Polymerase II Promoter Escape | 2.832832e-01 | 0.548 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 2.832832e-01 | 0.548 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 2.879562e-01 | 0.541 |
| R-HSA-69236 | G1 Phase | 2.879562e-01 | 0.541 |
| R-HSA-69231 | Cyclin D associated events in G1 | 2.879562e-01 | 0.541 |
| R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | 2.925991e-01 | 0.534 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.925991e-01 | 0.534 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 2.925991e-01 | 0.534 |
| R-HSA-69242 | S Phase | 2.946780e-01 | 0.531 |
| R-HSA-9758941 | Gastrulation | 2.970817e-01 | 0.527 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.972120e-01 | 0.527 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.972120e-01 | 0.527 |
| R-HSA-446652 | Interleukin-1 family signaling | 3.042859e-01 | 0.517 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 3.063486e-01 | 0.514 |
| R-HSA-69306 | DNA Replication | 3.066846e-01 | 0.513 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.066846e-01 | 0.513 |
| R-HSA-446728 | Cell junction organization | 3.077786e-01 | 0.512 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 3.108727e-01 | 0.507 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 3.108727e-01 | 0.507 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 3.108727e-01 | 0.507 |
| R-HSA-162587 | HIV Life Cycle | 3.162639e-01 | 0.500 |
| R-HSA-9711097 | Cellular response to starvation | 3.186544e-01 | 0.497 |
| R-HSA-877300 | Interferon gamma signaling | 3.210430e-01 | 0.493 |
| R-HSA-72187 | mRNA 3'-end processing | 3.242703e-01 | 0.489 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 3.242703e-01 | 0.489 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 3.242703e-01 | 0.489 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.242703e-01 | 0.489 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.273715e-01 | 0.485 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 3.286786e-01 | 0.483 |
| R-HSA-8956320 | Nucleotide biosynthesis | 3.286786e-01 | 0.483 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.329554e-01 | 0.478 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.330584e-01 | 0.477 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.380632e-01 | 0.471 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 3.417333e-01 | 0.466 |
| R-HSA-195721 | Signaling by WNT | 3.434068e-01 | 0.464 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.460287e-01 | 0.461 |
| R-HSA-1483166 | Synthesis of PA | 3.460287e-01 | 0.461 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 3.460287e-01 | 0.461 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 3.495336e-01 | 0.457 |
| R-HSA-6782135 | Dual incision in TC-NER | 3.502963e-01 | 0.456 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 3.502963e-01 | 0.456 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 3.545364e-01 | 0.450 |
| R-HSA-191859 | snRNP Assembly | 3.545364e-01 | 0.450 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.545364e-01 | 0.450 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 3.565980e-01 | 0.448 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 3.565980e-01 | 0.448 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.589470e-01 | 0.445 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 3.629345e-01 | 0.440 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.629345e-01 | 0.440 |
| R-HSA-1268020 | Mitochondrial protein import | 3.670929e-01 | 0.435 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.670929e-01 | 0.435 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 3.670929e-01 | 0.435 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 3.712244e-01 | 0.430 |
| R-HSA-373755 | Semaphorin interactions | 3.712244e-01 | 0.430 |
| R-HSA-1500931 | Cell-Cell communication | 3.753779e-01 | 0.426 |
| R-HSA-6798695 | Neutrophil degranulation | 3.792992e-01 | 0.421 |
| R-HSA-167172 | Transcription of the HIV genome | 3.914845e-01 | 0.407 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 3.914877e-01 | 0.407 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 3.994063e-01 | 0.399 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 3.994063e-01 | 0.399 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 3.994063e-01 | 0.399 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 4.033288e-01 | 0.394 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 4.052147e-01 | 0.392 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 4.072260e-01 | 0.390 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.072260e-01 | 0.390 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 4.097582e-01 | 0.387 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 4.110979e-01 | 0.386 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 4.149447e-01 | 0.382 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 4.187667e-01 | 0.378 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 4.209929e-01 | 0.376 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 4.225640e-01 | 0.374 |
| R-HSA-72172 | mRNA Splicing | 4.299940e-01 | 0.367 |
| R-HSA-73864 | RNA Polymerase I Transcription | 4.300849e-01 | 0.366 |
| R-HSA-6783783 | Interleukin-10 signaling | 4.300849e-01 | 0.366 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 4.375088e-01 | 0.359 |
| R-HSA-5654738 | Signaling by FGFR2 | 4.375088e-01 | 0.359 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 4.448369e-01 | 0.352 |
| R-HSA-73894 | DNA Repair | 4.519469e-01 | 0.345 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.520704e-01 | 0.345 |
| R-HSA-418990 | Adherens junctions interactions | 4.607379e-01 | 0.337 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.627460e-01 | 0.335 |
| R-HSA-162906 | HIV Infection | 4.799947e-01 | 0.319 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 4.800827e-01 | 0.319 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 4.902175e-01 | 0.310 |
| R-HSA-72312 | rRNA processing | 4.905128e-01 | 0.309 |
| R-HSA-9837999 | Mitochondrial protein degradation | 4.935521e-01 | 0.307 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 5.034268e-01 | 0.298 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 5.066758e-01 | 0.295 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 5.066758e-01 | 0.295 |
| R-HSA-190236 | Signaling by FGFR | 5.099038e-01 | 0.293 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 5.131108e-01 | 0.290 |
| R-HSA-9020702 | Interleukin-1 signaling | 5.194626e-01 | 0.284 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.288368e-01 | 0.277 |
| R-HSA-111885 | Opioid Signalling | 5.288368e-01 | 0.277 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.349853e-01 | 0.272 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.391206e-01 | 0.268 |
| R-HSA-211000 | Gene Silencing by RNA | 5.410544e-01 | 0.267 |
| R-HSA-74160 | Gene expression (Transcription) | 5.413933e-01 | 0.266 |
| R-HSA-2672351 | Stimuli-sensing channels | 5.440595e-01 | 0.264 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.470451e-01 | 0.262 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.558861e-01 | 0.255 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.616849e-01 | 0.251 |
| R-HSA-72766 | Translation | 5.649486e-01 | 0.248 |
| R-HSA-73857 | RNA Polymerase II Transcription | 5.696163e-01 | 0.244 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 5.702428e-01 | 0.244 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 5.734540e-01 | 0.242 |
| R-HSA-212436 | Generic Transcription Pathway | 5.816808e-01 | 0.235 |
| R-HSA-68875 | Mitotic Prophase | 5.841397e-01 | 0.233 |
| R-HSA-9824443 | Parasitic Infection Pathways | 5.863022e-01 | 0.232 |
| R-HSA-9658195 | Leishmania infection | 5.863022e-01 | 0.232 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 5.881145e-01 | 0.231 |
| R-HSA-162909 | Host Interactions of HIV factors | 5.949360e-01 | 0.226 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 6.002296e-01 | 0.222 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 6.002296e-01 | 0.222 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 6.002296e-01 | 0.222 |
| R-HSA-114608 | Platelet degranulation | 6.054546e-01 | 0.218 |
| R-HSA-9843745 | Adipogenesis | 6.182231e-01 | 0.209 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 6.232151e-01 | 0.205 |
| R-HSA-9664417 | Leishmania phagocytosis | 6.425449e-01 | 0.192 |
| R-HSA-9664407 | Parasite infection | 6.425449e-01 | 0.192 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 6.425449e-01 | 0.192 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 6.448910e-01 | 0.191 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.574271e-01 | 0.182 |
| R-HSA-8957322 | Metabolism of steroids | 6.589968e-01 | 0.181 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 6.675289e-01 | 0.176 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.697125e-01 | 0.174 |
| R-HSA-9609507 | Protein localization | 6.740372e-01 | 0.171 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 6.761785e-01 | 0.170 |
| R-HSA-1989781 | PPARA activates gene expression | 6.783058e-01 | 0.169 |
| R-HSA-9610379 | HCMV Late Events | 6.825190e-01 | 0.166 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 6.825190e-01 | 0.166 |
| R-HSA-9006936 | Signaling by TGFB family members | 6.887366e-01 | 0.162 |
| R-HSA-5619102 | SLC transporter disorders | 7.027791e-01 | 0.153 |
| R-HSA-72306 | tRNA processing | 7.105198e-01 | 0.148 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 7.158585e-01 | 0.145 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 7.161939e-01 | 0.145 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 7.161939e-01 | 0.145 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.430836e-01 | 0.129 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 7.496572e-01 | 0.125 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 7.672120e-01 | 0.115 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.835468e-01 | 0.106 |
| R-HSA-382551 | Transport of small molecules | 7.889995e-01 | 0.103 |
| R-HSA-8951664 | Neddylation | 7.947085e-01 | 0.100 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 8.065851e-01 | 0.093 |
| R-HSA-15869 | Metabolism of nucleotides | 8.141221e-01 | 0.089 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.201955e-01 | 0.086 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.271921e-01 | 0.082 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.496677e-01 | 0.071 |
| R-HSA-1483257 | Phospholipid metabolism | 8.743582e-01 | 0.058 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 9.206763e-01 | 0.036 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 9.239634e-01 | 0.034 |
| R-HSA-418594 | G alpha (i) signalling events | 9.409011e-01 | 0.026 |
| R-HSA-8978868 | Fatty acid metabolism | 9.409011e-01 | 0.026 |
| R-HSA-556833 | Metabolism of lipids | 9.909574e-01 | 0.004 |
| R-HSA-388396 | GPCR downstream signalling | 9.950884e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.972247e-01 | 0.001 |
| R-HSA-1430728 | Metabolism | 9.999797e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.789 | 0.098 | 1 | 0.791 |
PKR |
0.787 | 0.219 | 1 | 0.809 |
TAK1 |
0.783 | 0.098 | 1 | 0.751 |
VRK1 |
0.779 | 0.066 | 2 | 0.742 |
MST3 |
0.779 | 0.153 | 2 | 0.837 |
VRK2 |
0.778 | 0.052 | 1 | 0.821 |
MEKK2 |
0.774 | 0.041 | 2 | 0.774 |
MINK |
0.774 | 0.034 | 1 | 0.731 |
TNIK |
0.774 | 0.043 | 3 | 0.612 |
MYO3A |
0.773 | 0.055 | 1 | 0.758 |
ASK1 |
0.773 | -0.009 | 1 | 0.711 |
OSR1 |
0.773 | 0.064 | 2 | 0.792 |
MYO3B |
0.772 | 0.082 | 2 | 0.821 |
EEF2K |
0.772 | 0.034 | 3 | 0.587 |
MEK5 |
0.770 | -0.028 | 2 | 0.779 |
YSK1 |
0.770 | 0.078 | 2 | 0.827 |
LRRK2 |
0.769 | -0.046 | 2 | 0.804 |
LKB1 |
0.769 | 0.050 | -3 | 0.711 |
MPSK1 |
0.769 | 0.137 | 1 | 0.787 |
GCK |
0.769 | -0.005 | 1 | 0.732 |
MAP3K15 |
0.768 | 0.008 | 1 | 0.721 |
HGK |
0.768 | 0.015 | 3 | 0.613 |
CAMKK1 |
0.768 | 0.023 | -2 | 0.722 |
NEK1 |
0.768 | -0.011 | 1 | 0.759 |
MST2 |
0.767 | 0.005 | 1 | 0.732 |
MEKK6 |
0.767 | 0.022 | 1 | 0.731 |
CAMKK2 |
0.766 | 0.026 | -2 | 0.718 |
TAO2 |
0.766 | -0.017 | 2 | 0.813 |
MEKK1 |
0.766 | 0.034 | 1 | 0.775 |
NEK4 |
0.765 | 0.009 | 1 | 0.738 |
NEK5 |
0.765 | -0.009 | 1 | 0.774 |
HPK1 |
0.765 | 0.008 | 1 | 0.717 |
MOS |
0.765 | 0.158 | 1 | 0.778 |
MST1 |
0.764 | -0.044 | 1 | 0.720 |
BRAF |
0.764 | -0.025 | -4 | 0.675 |
TAO3 |
0.764 | 0.024 | 1 | 0.727 |
KHS2 |
0.764 | 0.013 | 1 | 0.719 |
KHS1 |
0.764 | -0.003 | 1 | 0.708 |
MEKK3 |
0.763 | -0.005 | 1 | 0.755 |
TTK |
0.762 | -0.051 | -2 | 0.652 |
BIKE |
0.762 | 0.052 | 1 | 0.695 |
ALPHAK3 |
0.762 | -0.042 | -1 | 0.748 |
PDK1 |
0.762 | -0.060 | 1 | 0.736 |
NEK11 |
0.761 | -0.038 | 1 | 0.742 |
NEK8 |
0.761 | -0.026 | 2 | 0.800 |
ANKRD3 |
0.761 | -0.004 | 1 | 0.806 |
BMPR2 |
0.760 | -0.064 | -2 | 0.763 |
MEK1 |
0.760 | -0.090 | 2 | 0.742 |
NIK |
0.760 | -0.039 | -3 | 0.710 |
MLK1 |
0.760 | 0.140 | 2 | 0.815 |
PRPK |
0.760 | 0.041 | -1 | 0.795 |
DLK |
0.759 | -0.020 | 1 | 0.781 |
STLK3 |
0.758 | -0.065 | 1 | 0.709 |
ZAK |
0.758 | 0.002 | 1 | 0.756 |
NLK |
0.757 | 0.077 | 1 | 0.751 |
PBK |
0.757 | 0.046 | 1 | 0.707 |
MLK3 |
0.756 | 0.158 | 2 | 0.786 |
CAMLCK |
0.756 | -0.024 | -2 | 0.749 |
LOK |
0.756 | 0.020 | -2 | 0.699 |
MLK2 |
0.756 | 0.070 | 2 | 0.808 |
MLK4 |
0.755 | 0.119 | 2 | 0.777 |
YSK4 |
0.754 | -0.001 | 1 | 0.706 |
DAPK2 |
0.753 | -0.061 | -3 | 0.695 |
CDKL1 |
0.753 | 0.021 | -3 | 0.634 |
PERK |
0.752 | 0.042 | -2 | 0.676 |
PRP4 |
0.751 | 0.011 | -3 | 0.670 |
ALK4 |
0.751 | -0.033 | -2 | 0.665 |
MEK2 |
0.751 | -0.122 | 2 | 0.737 |
JNK3 |
0.750 | 0.033 | 1 | 0.568 |
ATR |
0.749 | -0.022 | 1 | 0.729 |
PASK |
0.749 | -0.029 | -3 | 0.689 |
ICK |
0.749 | 0.036 | -3 | 0.665 |
HASPIN |
0.748 | 0.037 | -1 | 0.642 |
MST4 |
0.748 | 0.166 | 2 | 0.877 |
BUB1 |
0.748 | 0.129 | -5 | 0.690 |
ROCK2 |
0.748 | 0.024 | -3 | 0.590 |
DMPK1 |
0.747 | -0.007 | -3 | 0.548 |
AAK1 |
0.747 | 0.072 | 1 | 0.599 |
NEK9 |
0.747 | 0.048 | 2 | 0.814 |
ERK5 |
0.747 | 0.066 | 1 | 0.692 |
TLK2 |
0.747 | 0.048 | 1 | 0.739 |
CAMK1B |
0.747 | -0.050 | -3 | 0.677 |
BMPR1B |
0.747 | 0.078 | 1 | 0.743 |
P38A |
0.746 | 0.040 | 1 | 0.615 |
JNK2 |
0.746 | 0.041 | 1 | 0.539 |
GRK7 |
0.746 | 0.089 | 1 | 0.680 |
SMMLCK |
0.746 | -0.050 | -3 | 0.639 |
GRK5 |
0.746 | 0.038 | -3 | 0.751 |
RAF1 |
0.746 | -0.005 | 1 | 0.760 |
TAO1 |
0.745 | -0.036 | 1 | 0.674 |
ALK2 |
0.745 | -0.028 | -2 | 0.644 |
RIPK1 |
0.745 | -0.014 | 1 | 0.803 |
COT |
0.745 | 0.137 | 2 | 0.782 |
ACVR2B |
0.745 | 0.033 | -2 | 0.628 |
RIPK3 |
0.745 | 0.044 | 3 | 0.620 |
GSK3B |
0.745 | 0.126 | 4 | 0.550 |
TGFBR1 |
0.744 | 0.023 | -2 | 0.627 |
GRK6 |
0.744 | 0.054 | 1 | 0.771 |
SLK |
0.744 | -0.027 | -2 | 0.664 |
GSK3A |
0.743 | 0.131 | 4 | 0.557 |
NEK2 |
0.743 | 0.032 | 2 | 0.799 |
CHAK2 |
0.743 | 0.021 | -1 | 0.755 |
HRI |
0.742 | -0.061 | -2 | 0.694 |
PKCD |
0.742 | 0.077 | 2 | 0.797 |
NEK3 |
0.742 | 0.022 | 1 | 0.717 |
IRAK4 |
0.742 | -0.013 | 1 | 0.782 |
P38B |
0.742 | 0.034 | 1 | 0.537 |
ERK7 |
0.742 | 0.104 | 2 | 0.652 |
CAMK2G |
0.742 | -0.002 | 2 | 0.706 |
ACVR2A |
0.741 | 0.012 | -2 | 0.616 |
WNK4 |
0.741 | -0.037 | -2 | 0.770 |
PINK1 |
0.740 | -0.022 | 1 | 0.798 |
PLK1 |
0.740 | -0.020 | -2 | 0.661 |
WNK1 |
0.740 | 0.031 | -2 | 0.786 |
MOK |
0.739 | 0.091 | 1 | 0.713 |
GRK1 |
0.739 | 0.167 | -2 | 0.736 |
ERK2 |
0.739 | 0.012 | 1 | 0.582 |
HIPK1 |
0.738 | 0.041 | 1 | 0.687 |
DSTYK |
0.738 | 0.047 | 2 | 0.812 |
DAPK3 |
0.738 | -0.065 | -3 | 0.606 |
PKCA |
0.738 | 0.107 | 2 | 0.773 |
PDHK4 |
0.737 | -0.092 | 1 | 0.769 |
SKMLCK |
0.737 | -0.024 | -2 | 0.743 |
MAK |
0.737 | 0.081 | -2 | 0.734 |
LATS1 |
0.737 | -0.052 | -3 | 0.676 |
GRK2 |
0.737 | 0.064 | -2 | 0.697 |
PDHK1 |
0.736 | -0.028 | 1 | 0.764 |
DRAK1 |
0.736 | 0.012 | 1 | 0.731 |
TLK1 |
0.736 | -0.064 | -2 | 0.676 |
ERK1 |
0.735 | 0.050 | 1 | 0.534 |
IRE1 |
0.735 | 0.061 | 1 | 0.789 |
CHAK1 |
0.735 | -0.015 | 2 | 0.756 |
PKN2 |
0.735 | 0.035 | -3 | 0.658 |
BMPR1A |
0.735 | 0.032 | 1 | 0.719 |
P38G |
0.734 | 0.030 | 1 | 0.473 |
ROCK1 |
0.734 | -0.002 | -3 | 0.551 |
PKN3 |
0.733 | -0.012 | -3 | 0.643 |
CDKL5 |
0.733 | 0.039 | -3 | 0.620 |
MASTL |
0.733 | -0.161 | -2 | 0.721 |
NEK7 |
0.732 | 0.022 | -3 | 0.730 |
MRCKB |
0.732 | 0.005 | -3 | 0.549 |
PIM3 |
0.731 | 0.027 | -3 | 0.654 |
NEK6 |
0.731 | 0.095 | -2 | 0.715 |
CDK5 |
0.731 | 0.030 | 1 | 0.609 |
TTBK2 |
0.730 | -0.003 | 2 | 0.685 |
DAPK1 |
0.730 | -0.052 | -3 | 0.596 |
CDC7 |
0.729 | 0.054 | 1 | 0.740 |
P38D |
0.729 | 0.032 | 1 | 0.480 |
PKCH |
0.729 | 0.046 | 2 | 0.744 |
PIM2 |
0.729 | 0.006 | -3 | 0.550 |
MTOR |
0.729 | -0.010 | 1 | 0.700 |
JNK1 |
0.729 | 0.008 | 1 | 0.523 |
P70S6KB |
0.729 | 0.006 | -3 | 0.601 |
ULK2 |
0.729 | 0.007 | 2 | 0.749 |
PKCZ |
0.728 | 0.035 | 2 | 0.785 |
PKCB |
0.728 | 0.082 | 2 | 0.771 |
CRIK |
0.727 | 0.010 | -3 | 0.511 |
HIPK3 |
0.727 | 0.012 | 1 | 0.668 |
PIM1 |
0.727 | 0.001 | -3 | 0.578 |
PKCG |
0.727 | 0.075 | 2 | 0.770 |
PKCE |
0.726 | 0.067 | 2 | 0.759 |
SMG1 |
0.726 | -0.027 | 1 | 0.678 |
CDK1 |
0.726 | 0.015 | 1 | 0.560 |
CDK14 |
0.725 | 0.017 | 1 | 0.578 |
IKKB |
0.724 | 0.087 | -2 | 0.733 |
DYRK2 |
0.723 | 0.016 | 1 | 0.668 |
IRE2 |
0.723 | -0.029 | 2 | 0.723 |
SGK3 |
0.723 | 0.003 | -3 | 0.582 |
STK33 |
0.723 | -0.054 | 2 | 0.605 |
PKCI |
0.722 | 0.044 | 2 | 0.775 |
WNK3 |
0.721 | -0.137 | 1 | 0.753 |
PAK1 |
0.721 | -0.007 | -2 | 0.696 |
MRCKA |
0.720 | -0.040 | -3 | 0.552 |
CDK6 |
0.720 | -0.003 | 1 | 0.555 |
IRAK1 |
0.720 | -0.158 | -1 | 0.666 |
HIPK4 |
0.719 | 0.051 | 1 | 0.767 |
TGFBR2 |
0.719 | -0.039 | -2 | 0.608 |
RSK2 |
0.719 | 0.040 | -3 | 0.578 |
AKT2 |
0.719 | 0.001 | -3 | 0.496 |
TSSK2 |
0.719 | -0.101 | -5 | 0.721 |
TBK1 |
0.718 | -0.074 | 1 | 0.671 |
PLK3 |
0.718 | -0.087 | 2 | 0.659 |
CDK2 |
0.718 | -0.026 | 1 | 0.638 |
IKKA |
0.718 | 0.107 | -2 | 0.720 |
GRK3 |
0.718 | 0.077 | -2 | 0.651 |
PAK2 |
0.717 | -0.069 | -2 | 0.685 |
PKCT |
0.717 | 0.025 | 2 | 0.759 |
GRK4 |
0.717 | -0.035 | -2 | 0.736 |
CDK16 |
0.717 | 0.038 | 1 | 0.493 |
CLK3 |
0.717 | 0.009 | 1 | 0.716 |
HUNK |
0.717 | -0.141 | 2 | 0.709 |
DNAPK |
0.716 | -0.076 | 1 | 0.573 |
CDK4 |
0.716 | -0.009 | 1 | 0.529 |
MYLK4 |
0.716 | -0.052 | -2 | 0.672 |
IKKE |
0.716 | -0.060 | 1 | 0.666 |
AURB |
0.715 | 0.017 | -2 | 0.585 |
RIPK2 |
0.715 | -0.164 | 1 | 0.706 |
DCAMKL1 |
0.715 | -0.087 | -3 | 0.584 |
NUAK2 |
0.715 | -0.071 | -3 | 0.631 |
AMPKA1 |
0.715 | -0.106 | -3 | 0.661 |
CDK18 |
0.714 | 0.037 | 1 | 0.529 |
CDK8 |
0.714 | 0.030 | 1 | 0.599 |
CAMK2D |
0.714 | -0.038 | -3 | 0.672 |
DYRK1A |
0.713 | -0.026 | 1 | 0.660 |
DYRK3 |
0.713 | -0.001 | 1 | 0.711 |
CDK17 |
0.713 | 0.008 | 1 | 0.478 |
CDK10 |
0.712 | 0.030 | 1 | 0.569 |
P90RSK |
0.712 | -0.009 | -3 | 0.586 |
CDK3 |
0.712 | 0.016 | 1 | 0.496 |
MARK4 |
0.712 | -0.114 | 4 | 0.658 |
AKT1 |
0.712 | -0.004 | -3 | 0.509 |
PAK3 |
0.712 | -0.048 | -2 | 0.690 |
ATM |
0.711 | -0.082 | 1 | 0.658 |
TTBK1 |
0.711 | -0.042 | 2 | 0.604 |
NDR1 |
0.711 | -0.021 | -3 | 0.641 |
ULK1 |
0.711 | -0.073 | -3 | 0.694 |
PLK2 |
0.710 | -0.055 | -3 | 0.627 |
RSK4 |
0.710 | 0.029 | -3 | 0.539 |
GCN2 |
0.710 | 0.000 | 2 | 0.771 |
CK2A2 |
0.710 | 0.118 | 1 | 0.642 |
HIPK2 |
0.710 | 0.033 | 1 | 0.586 |
SGK1 |
0.710 | -0.014 | -3 | 0.423 |
CDK13 |
0.709 | -0.019 | 1 | 0.566 |
DCAMKL2 |
0.709 | -0.117 | -3 | 0.598 |
CDK7 |
0.709 | 0.006 | 1 | 0.593 |
CDK12 |
0.709 | -0.013 | 1 | 0.541 |
BMPR2_TYR |
0.708 | 0.157 | -1 | 0.854 |
SRPK3 |
0.708 | -0.046 | -3 | 0.574 |
CK2A1 |
0.708 | 0.126 | 1 | 0.626 |
PKG2 |
0.708 | 0.017 | -2 | 0.629 |
PDHK3_TYR |
0.708 | 0.140 | 4 | 0.777 |
SRPK1 |
0.708 | -0.006 | -3 | 0.589 |
PLK4 |
0.708 | -0.088 | 2 | 0.577 |
TSSK1 |
0.707 | -0.082 | -3 | 0.674 |
PRKD3 |
0.707 | -0.019 | -3 | 0.578 |
PKACG |
0.707 | -0.000 | -2 | 0.675 |
DYRK1B |
0.707 | -0.030 | 1 | 0.601 |
RSK3 |
0.706 | 0.008 | -3 | 0.587 |
BCKDK |
0.706 | -0.071 | -1 | 0.668 |
PKMYT1_TYR |
0.706 | 0.123 | 3 | 0.668 |
AURA |
0.706 | 0.002 | -2 | 0.545 |
MNK1 |
0.705 | -0.010 | -2 | 0.708 |
CK1D |
0.705 | 0.000 | -3 | 0.436 |
CK1A2 |
0.705 | 0.010 | -3 | 0.425 |
CHK2 |
0.705 | -0.070 | -3 | 0.439 |
CDK9 |
0.704 | -0.020 | 1 | 0.572 |
MAPKAPK3 |
0.704 | -0.029 | -3 | 0.596 |
CLK4 |
0.704 | -0.046 | -3 | 0.562 |
QIK |
0.704 | -0.138 | -3 | 0.667 |
AURC |
0.704 | 0.050 | -2 | 0.592 |
CAMK1G |
0.704 | -0.072 | -3 | 0.564 |
CAMK4 |
0.704 | -0.139 | -3 | 0.618 |
YANK3 |
0.703 | -0.036 | 2 | 0.403 |
P70S6K |
0.703 | -0.012 | -3 | 0.526 |
NIM1 |
0.702 | -0.122 | 3 | 0.584 |
CAMK2B |
0.702 | -0.041 | 2 | 0.671 |
MELK |
0.702 | -0.106 | -3 | 0.608 |
CDK19 |
0.701 | 0.032 | 1 | 0.562 |
PDHK4_TYR |
0.701 | 0.048 | 2 | 0.794 |
AMPKA2 |
0.701 | -0.112 | -3 | 0.621 |
CHK1 |
0.701 | -0.171 | -3 | 0.615 |
TESK1_TYR |
0.700 | 0.007 | 3 | 0.659 |
MAP2K7_TYR |
0.700 | -0.040 | 2 | 0.782 |
MNK2 |
0.700 | -0.011 | -2 | 0.693 |
YANK2 |
0.700 | -0.038 | 2 | 0.408 |
PRKD1 |
0.699 | 0.022 | -3 | 0.668 |
PDHK1_TYR |
0.699 | 0.023 | -1 | 0.821 |
MAP2K6_TYR |
0.699 | 0.021 | -1 | 0.800 |
CK1E |
0.699 | 0.013 | -3 | 0.468 |
LIMK2_TYR |
0.699 | 0.078 | -3 | 0.730 |
MSK1 |
0.699 | -0.036 | -3 | 0.582 |
PKACB |
0.698 | 0.013 | -2 | 0.600 |
MAP2K4_TYR |
0.698 | 0.001 | -1 | 0.793 |
PINK1_TYR |
0.698 | -0.032 | 1 | 0.772 |
CAMK2A |
0.698 | -0.046 | 2 | 0.688 |
NDR2 |
0.697 | 0.024 | -3 | 0.668 |
DYRK4 |
0.697 | -0.018 | 1 | 0.575 |
SSTK |
0.697 | -0.088 | 4 | 0.621 |
PHKG1 |
0.697 | -0.036 | -3 | 0.637 |
EPHA6 |
0.697 | 0.048 | -1 | 0.831 |
PRKD2 |
0.696 | 0.014 | -3 | 0.577 |
MSK2 |
0.696 | -0.065 | -3 | 0.586 |
CAMK1D |
0.694 | -0.104 | -3 | 0.489 |
MARK2 |
0.693 | -0.139 | 4 | 0.548 |
LIMK1_TYR |
0.693 | -0.039 | 2 | 0.791 |
WEE1_TYR |
0.692 | 0.064 | -1 | 0.707 |
CLK1 |
0.691 | -0.046 | -3 | 0.541 |
AKT3 |
0.691 | -0.007 | -3 | 0.444 |
PKN1 |
0.691 | -0.036 | -3 | 0.532 |
MARK3 |
0.691 | -0.109 | 4 | 0.586 |
QSK |
0.690 | -0.122 | 4 | 0.630 |
MST1R |
0.690 | -0.052 | 3 | 0.620 |
TYK2 |
0.690 | -0.042 | 1 | 0.733 |
LCK |
0.690 | 0.077 | -1 | 0.833 |
SNRK |
0.690 | -0.150 | 2 | 0.646 |
FGR |
0.689 | -0.005 | 1 | 0.768 |
KDR |
0.689 | -0.015 | 3 | 0.603 |
JAK2 |
0.689 | -0.045 | 1 | 0.728 |
TXK |
0.689 | 0.075 | 1 | 0.760 |
HCK |
0.688 | 0.031 | -1 | 0.813 |
RET |
0.688 | -0.085 | 1 | 0.737 |
MARK1 |
0.688 | -0.160 | 4 | 0.599 |
LATS2 |
0.687 | -0.050 | -5 | 0.694 |
ROS1 |
0.687 | -0.069 | 3 | 0.596 |
EPHB4 |
0.687 | -0.030 | -1 | 0.767 |
ABL2 |
0.686 | 0.003 | -1 | 0.765 |
CSF1R |
0.686 | -0.064 | 3 | 0.618 |
ABL1 |
0.685 | 0.005 | -1 | 0.756 |
TNNI3K_TYR |
0.685 | 0.045 | 1 | 0.791 |
MAPKAPK2 |
0.685 | -0.020 | -3 | 0.537 |
PAK6 |
0.685 | -0.027 | -2 | 0.635 |
JAK3 |
0.685 | -0.052 | 1 | 0.718 |
PHKG2 |
0.685 | -0.050 | -3 | 0.596 |
FLT1 |
0.685 | -0.008 | -1 | 0.790 |
FYN |
0.684 | 0.072 | -1 | 0.835 |
BLK |
0.684 | 0.050 | -1 | 0.823 |
CAMK1A |
0.684 | -0.089 | -3 | 0.475 |
PKACA |
0.684 | -0.017 | -2 | 0.562 |
TYRO3 |
0.684 | -0.104 | 3 | 0.601 |
YES1 |
0.683 | -0.042 | -1 | 0.776 |
KIT |
0.683 | -0.060 | 3 | 0.616 |
ITK |
0.682 | -0.002 | -1 | 0.768 |
SBK |
0.682 | -0.075 | -3 | 0.378 |
FLT3 |
0.682 | -0.083 | 3 | 0.592 |
SRMS |
0.681 | -0.032 | 1 | 0.752 |
JAK1 |
0.681 | 0.001 | 1 | 0.684 |
NUAK1 |
0.681 | -0.124 | -3 | 0.583 |
BMX |
0.681 | 0.015 | -1 | 0.747 |
TNK2 |
0.680 | -0.061 | 3 | 0.575 |
FER |
0.680 | -0.109 | 1 | 0.749 |
DDR1 |
0.680 | -0.155 | 4 | 0.695 |
FAM20C |
0.680 | -0.034 | 2 | 0.461 |
MAPKAPK5 |
0.679 | -0.121 | -3 | 0.547 |
PDGFRB |
0.679 | -0.096 | 3 | 0.608 |
SIK |
0.679 | -0.129 | -3 | 0.585 |
EPHA4 |
0.679 | -0.053 | 2 | 0.658 |
PRKX |
0.679 | 0.027 | -3 | 0.470 |
CLK2 |
0.679 | -0.015 | -3 | 0.544 |
MET |
0.679 | -0.048 | 3 | 0.593 |
SRPK2 |
0.678 | -0.053 | -3 | 0.501 |
EPHB1 |
0.677 | -0.074 | 1 | 0.748 |
LYN |
0.677 | -0.015 | 3 | 0.591 |
CK1G1 |
0.676 | 0.002 | -3 | 0.494 |
PTK6 |
0.676 | -0.055 | -1 | 0.676 |
FLT4 |
0.676 | -0.078 | 3 | 0.635 |
FGFR2 |
0.676 | -0.139 | 3 | 0.623 |
INSRR |
0.676 | -0.118 | 3 | 0.589 |
EPHA7 |
0.676 | -0.035 | 2 | 0.674 |
NEK10_TYR |
0.675 | -0.048 | 1 | 0.604 |
ERBB2 |
0.675 | -0.085 | 1 | 0.685 |
KIS |
0.675 | -0.017 | 1 | 0.615 |
TEC |
0.675 | -0.050 | -1 | 0.703 |
LTK |
0.675 | -0.077 | 3 | 0.590 |
EPHB3 |
0.674 | -0.081 | -1 | 0.749 |
MERTK |
0.674 | -0.068 | 3 | 0.612 |
PTK2 |
0.674 | 0.073 | -1 | 0.824 |
TNK1 |
0.674 | -0.084 | 3 | 0.608 |
SRC |
0.673 | -0.002 | -1 | 0.797 |
BTK |
0.673 | -0.109 | -1 | 0.718 |
AXL |
0.672 | -0.109 | 3 | 0.608 |
TEK |
0.672 | -0.151 | 3 | 0.571 |
NTRK1 |
0.672 | -0.106 | -1 | 0.733 |
FRK |
0.672 | -0.056 | -1 | 0.810 |
SYK |
0.672 | 0.064 | -1 | 0.803 |
EPHB2 |
0.672 | -0.081 | -1 | 0.757 |
BRSK1 |
0.671 | -0.129 | -3 | 0.612 |
MATK |
0.671 | -0.048 | -1 | 0.700 |
PDGFRA |
0.671 | -0.147 | 3 | 0.608 |
ALK |
0.671 | -0.107 | 3 | 0.551 |
EPHA3 |
0.671 | -0.085 | 2 | 0.661 |
FGFR1 |
0.671 | -0.150 | 3 | 0.598 |
NTRK3 |
0.670 | -0.060 | -1 | 0.698 |
BRSK2 |
0.670 | -0.158 | -3 | 0.631 |
PAK5 |
0.670 | -0.063 | -2 | 0.566 |
FGFR3 |
0.669 | -0.130 | 3 | 0.608 |
EPHA8 |
0.669 | -0.037 | -1 | 0.780 |
NTRK2 |
0.668 | -0.123 | 3 | 0.594 |
INSR |
0.668 | -0.107 | 3 | 0.579 |
EPHA1 |
0.668 | -0.090 | 3 | 0.579 |
PTK2B |
0.667 | -0.040 | -1 | 0.724 |
EGFR |
0.667 | -0.044 | 1 | 0.612 |
CSK |
0.666 | -0.076 | 2 | 0.680 |
CK1G3 |
0.665 | -0.041 | -3 | 0.332 |
EPHA5 |
0.661 | -0.097 | 2 | 0.646 |
PKG1 |
0.661 | -0.041 | -2 | 0.561 |
FGFR4 |
0.660 | -0.080 | -1 | 0.721 |
EPHA2 |
0.659 | -0.044 | -1 | 0.765 |
DDR2 |
0.659 | -0.108 | 3 | 0.574 |
ERBB4 |
0.659 | -0.030 | 1 | 0.631 |
PAK4 |
0.659 | -0.065 | -2 | 0.566 |
MUSK |
0.657 | -0.075 | 1 | 0.594 |
IGF1R |
0.657 | -0.098 | 3 | 0.540 |
CK1G2 |
0.657 | -0.014 | -3 | 0.418 |
FES |
0.653 | -0.055 | -1 | 0.709 |
CK1A |
0.653 | 0.016 | -3 | 0.363 |
ZAP70 |
0.652 | 0.005 | -1 | 0.759 |