Motif 1055 (n=82)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| O15554 | KCNN4 | T329 | psp | Intermediate conductance calcium-activated potassium channel protein 4 (SKCa 4) (SKCa4) (hSK4) (Gardos channel) (IKCa1) (hIK1) (KCa3.1) (Putative Gardos channel) (hKCa4) | Intermediate conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10026195, PubMed:10961988, PubMed:11425865, PubMed:15831468, PubMed:17157250, PubMed:18796614, PubMed:26148990, PubMed:9326665, PubMed:9380751, PubMed:9407042). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 25 picosiemens (PubMed:9326665, PubMed:9380751, PubMed:9407042). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:9326665, PubMed:9380751, PubMed:9407042). Controls calcium influx during vascular contractility by being responsible of membrane hyperpolarization induced by vasoactive factors in proliferative vascular smooth muscle cell types (By similarity). Following calcium influx, the consecutive activation of KCNN4 channel leads to a hyperpolarization of the cell membrane potential and hence an increase of the electrical driving force for further calcium influx promoting sustained calcium entry in response to stimulation with chemotactic peptides (PubMed:26418693). Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis through activation by PI(3)P (PubMed:24591580). {ECO:0000250|UniProtKB:Q9QYW1, ECO:0000269|PubMed:10026195, ECO:0000269|PubMed:10961988, ECO:0000269|PubMed:11425865, ECO:0000269|PubMed:15831468, ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:18796614, ECO:0000269|PubMed:24591580, ECO:0000269|PubMed:26148990, ECO:0000269|PubMed:26418693, ECO:0000269|PubMed:9326665, ECO:0000269|PubMed:9380751, ECO:0000269|PubMed:9407042}. |
| O43464 | HTRA2 | T215 | ochoa | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). {ECO:0000269|PubMed:10873535, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560, ECO:0000269|PubMed:36758104, ECO:0000269|PubMed:36758105}.; FUNCTION: [Isoform 2]: Seems to be proteolytically inactive. {ECO:0000269|PubMed:10995577}. |
| O43707 | ACTN4 | T249 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60664 | PLIN3 | T38 | ochoa | Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17) | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}. |
| O75044 | SRGAP2 | T1014 | ochoa | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:27373832, ECO:0000269|PubMed:28333212}. |
| O75363 | BCAS1 | T66 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O95684 | CEP43 | T234 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| P00441 | SOD1 | T89 | ochoa | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {ECO:0000269|PubMed:24140062}. |
| P06733 | ENO1 | T41 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P09104 | ENO2 | T41 | ochoa | Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE) | Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}. |
| P0DPH7 | TUBA3C | T382 | ochoa | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P0DPH8 | TUBA3D | T382 | ochoa | Tubulin alpha-3D chain (EC 3.6.5.-) (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P11021 | HSPA5 | T62 | psp | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) | Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:11907036, PubMed:1550958, PubMed:19538957, PubMed:36739529). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Also binds and inactivates EIF2AK3/PERK in unstressed cells (PubMed:11907036). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (PubMed:11907036). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166). {ECO:0000250|UniProtKB:G3I8R9, ECO:0000250|UniProtKB:P20029, ECO:0000269|PubMed:11907036, ECO:0000269|PubMed:1550958, ECO:0000269|PubMed:19538957, ECO:0000269|PubMed:2294010, ECO:0000269|PubMed:23769672, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:26045166, ECO:0000269|PubMed:28332555, ECO:0000269|PubMed:29719251, ECO:0000269|PubMed:36739529}.; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus (PubMed:15098107, PubMed:28053106, PubMed:33432092). Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells (PubMed:15098107). {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}.; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi (PubMed:20484814, PubMed:24355926, PubMed:32487760). Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression (PubMed:32487760). {ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:32487760}. |
| P12814 | ACTN1 | T230 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P13688 | CEACAM1 | T457 | psp | Cell adhesion molecule CEACAM1 (Biliary glycoprotein 1) (BGP-1) (Carcinoembryonic antigen-related cell adhesion molecule 1) (CEA cell adhesion molecule 1) (CD antigen CD66a) | [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by down-regulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:16291724, ECO:0000269|PubMed:18424730, ECO:0000269|PubMed:23696226, ECO:0000269|PubMed:25363763}.; FUNCTION: [Isoform 8]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}. |
| P13929 | ENO3 | T41 | ochoa | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase) | Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Appears to have a function in striated muscle development and regeneration. {ECO:0000250|UniProtKB:P15429}. |
| P29317 | EPHA2 | T774 | ochoa | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P29320 | EPHA3 | T781 | ochoa | Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
| P35408 | PTGER4 | T225 | ochoa | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P49321 | NASP | T349 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P49757 | NUMB | T198 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P49790 | NUP153 | T307 | ochoa | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P51003 | PAPOLA | T109 | ochoa | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. |
| P54756 | EPHA5 | T835 | ochoa | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}. |
| P54764 | EPHA4 | T781 | ochoa | Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) | Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (By similarity). {ECO:0000250|UniProtKB:Q03137, ECO:0000269|PubMed:17143272}. |
| P60709 | ACTB | T303 | ochoa | Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:25255767, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| P62491 | RAB11A | S42 | ochoa | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15601896, PubMed:15689490, PubMed:17462998, PubMed:19542231, PubMed:20026645, PubMed:20890297, PubMed:21282656, PubMed:26032412). The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization (PubMed:21282656). Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells (PubMed:17462998). Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane (PubMed:19542231). Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (PubMed:15689490). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}. |
| P62736 | ACTA2 | T305 | ochoa | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P63261 | ACTG1 | T303 | ochoa | Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity). {ECO:0000250|UniProtKB:P63260, ECO:0000305|PubMed:29581253}. |
| P63267 | ACTG2 | T304 | ochoa | Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68032 | ACTC1 | T305 | ochoa | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| P68104 | EEF1A1 | T227 | ochoa | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, PubMed:36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). {ECO:0000250|UniProtKB:P68105, ECO:0000269|PubMed:17177976, ECO:0000269|PubMed:26593721, ECO:0000269|PubMed:26651998, ECO:0000269|PubMed:36123449, ECO:0000269|PubMed:36264623, ECO:0000269|PubMed:36638793}.; FUNCTION: (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. {ECO:0000269|PubMed:33495306}. |
| P68363 | TUBA1B | T382 | ochoa | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | T382 | ochoa | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78371 | CCT2 | T428 | ochoa | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| Q13428 | TCOF1 | T1260 | ochoa | Treacle protein (Treacher Collins syndrome protein) | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}. |
| Q14699 | RFTN1 | T180 | ochoa | Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein) | Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:21266579, PubMed:27022195). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216). {ECO:0000250|UniProtKB:Q6A0D4, ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}. |
| Q15907 | RAB11B | S42 | ochoa | Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970, PubMed:26032412). The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis (PubMed:14627637, PubMed:19029296, PubMed:19244346, PubMed:20717956, PubMed:21248079, PubMed:22129970). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). {ECO:0000269|PubMed:14627637, ECO:0000269|PubMed:19029296, ECO:0000269|PubMed:19244346, ECO:0000269|PubMed:20717956, ECO:0000269|PubMed:21248079, ECO:0000269|PubMed:22129970, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:26032412, ECO:0000269|PubMed:31204173}. |
| Q16659 | MAPK6 | T389 | ochoa | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. |
| Q3MII6 | TBC1D25 | T160 | ochoa | TBC1 domain family member 25 | Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269|PubMed:21383079}. |
| Q5VTE0 | EEF1A1P5 | T227 | ochoa | Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5) | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}. |
| Q69YH5 | CDCA2 | T296 | ochoa | Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man) | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Q6NUK4 | REEP3 | T158 | ochoa | Receptor expression-enhancing protein 3 | Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. {ECO:0000269|PubMed:23911198}. |
| Q71U36 | TUBA1A | T382 | ochoa | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q7Z6Z7 | HUWE1 | T1090 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z6Z7 | HUWE1 | T1091 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q86W50 | METTL16 | T335 | ochoa | RNA N(6)-adenosine-methyltransferase METTL16 (EC 2.1.1.348) (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346) | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311). {ECO:0000269|PubMed:27872311, ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299, ECO:0000269|PubMed:32266935, ECO:0000269|PubMed:33428944}. |
| Q8IV36 | HID1 | T637 | ochoa | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) | May play an important role in the development of cancers in a broad range of tissues. {ECO:0000269|PubMed:11281419}. |
| Q92833 | JARID2 | T824 | ochoa | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q96DT7 | ZBTB10 | T646 | ochoa | Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) | May be involved in transcriptional regulation. |
| Q96J84 | KIRREL1 | T563 | ochoa | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:31472902). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:31472902}. |
| Q9BUH8 | BEGAIN | S197 | ochoa | Brain-enriched guanylate kinase-associated protein | May sustain the structure of the postsynaptic density (PSD). |
| Q9BVV8 | FAM174C | T109 | ochoa | Protein FAM174C | None |
| Q9BWT3 | PAPOLG | T108 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BXW9 | FANCD2 | T691 | ochoa|psp | Fanconi anemia group D2 protein (Protein FACD2) | Required for maintenance of chromosomal stability (PubMed:11239453, PubMed:14517836). Promotes accurate and efficient pairing of homologs during meiosis (PubMed:14517836). Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing (PubMed:15671039, PubMed:15650050, PubMed:30335751, PubMed:36385258). The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (By similarity). May participate in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:15377654). Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (PubMed:15454491, PubMed:15661754). Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress (PubMed:15661754, PubMed:19465921). Promotes BRCA2/FANCD1 loading onto damaged chromatin (PubMed:11239454, PubMed:12239151, PubMed:12086603, PubMed:15115758, PubMed:15199141, PubMed:15671039, PubMed:18212739). May also be involved in B-cell immunoglobulin isotype switching. {ECO:0000250|UniProtKB:Q68Y81, ECO:0000269|PubMed:11239453, ECO:0000269|PubMed:11239454, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12239151, ECO:0000269|PubMed:14517836, ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15377654, ECO:0000269|PubMed:15454491, ECO:0000269|PubMed:15650050, ECO:0000269|PubMed:15661754, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:19465921, ECO:0000269|PubMed:30335751, ECO:0000269|PubMed:36385258}. |
| Q9BY77 | POLDIP3 | T45 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9H2D6 | TRIOBP | T1952 | ochoa | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9NQS7 | INCENP | T135 | ochoa | Inner centromere protein | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250|UniProtKB:P53352, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428, ECO:0000269|PubMed:21346195, ECO:0000269|PubMed:27332895}. |
| Q9NY65 | TUBA8 | T382 | ochoa | Tubulin alpha-8 chain (EC 3.6.5.-) (Alpha-tubulin 8) (Tubulin alpha chain-like 2) [Cleaved into: Dephenylalaninated tubulin alpha-8 chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9UJA5 | TRMT6 | T468 | ochoa | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) | Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537). {ECO:0000269|PubMed:16043508, ECO:0000269|PubMed:29072297, ECO:0000269|PubMed:29107537}. |
| Q9UJY4 | GGA2 | T287 | ochoa | ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear) | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). {ECO:0000269|PubMed:10747088, ECO:0000269|PubMed:15615712, ECO:0000269|PubMed:27901063}. |
| Q9Y490 | TLN1 | T1142 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| P04040 | CAT | T28 | Sugiyama | Catalase (EC 1.11.1.6) | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}. |
| P56192 | MARS1 | T710 | Sugiyama | Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). {ECO:0000269|PubMed:10791971, ECO:0000269|PubMed:11714285, ECO:0000269|PubMed:33909043}. |
| P25205 | MCM3 | T369 | Sugiyama | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| P46776 | RPL27A | T95 | Sugiyama | Large ribosomal subunit protein uL15 (60S ribosomal protein L27a) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P11142 | HSPA8 | T37 | Sugiyama | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661, PubMed:2799391, PubMed:36586411). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:12526792, PubMed:21148293, PubMed:21150129, PubMed:23018488, PubMed:24732912, PubMed:27916661). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24121476, PubMed:24318877, PubMed:26865365, PubMed:27474739). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (PubMed:11559757, PubMed:2799391, PubMed:36586411). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (PubMed:11559757, PubMed:2799391, PubMed:36586411). In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane (PubMed:15894275). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity). {ECO:0000250|UniProtKB:P19120, ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:11559757, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15894275, ECO:0000269|PubMed:21148293, ECO:0000269|PubMed:21150129, ECO:0000269|PubMed:23018488, ECO:0000269|PubMed:23990462, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24732912, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:27916661, ECO:0000269|PubMed:2799391, ECO:0000269|PubMed:36586411, ECO:0000303|PubMed:24121476, ECO:0000303|PubMed:26865365}. |
| P34931 | HSPA1L | T39 | Sugiyama | Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom) (Heat shock protein family A member 1L) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}. |
| P54652 | HSPA2 | T38 | Sugiyama | Heat shock-related 70 kDa protein 2 (Heat shock 70 kDa protein 2) (Heat shock protein family A member 2) | Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity). {ECO:0000250|UniProtKB:P17156, ECO:0000303|PubMed:26865365}. |
| P62857 | RPS28 | T28 | Sugiyama | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}. |
| O75582 | RPS6KA5 | T34 | Sugiyama | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:18511904, PubMed:9687510, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810). {ECO:0000250|UniProtKB:Q8C050, ECO:0000269|PubMed:11909979, ECO:0000269|PubMed:12569367, ECO:0000269|PubMed:12628924, ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:12773393, ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:18511904, ECO:0000269|PubMed:25851810, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| P43034 | PAFAH1B1 | T247 | Sugiyama | Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity). {ECO:0000250|UniProtKB:P43033, ECO:0000250|UniProtKB:P63005, ECO:0000269|PubMed:15173193, ECO:0000269|PubMed:22956769}. |
| P46779 | RPL28 | T80 | Sugiyama | Large ribosomal subunit protein eL28 (60S ribosomal protein L28) | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| Q13873 | BMPR2 | T803 | Sugiyama | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| P57721 | PCBP3 | T174 | Sugiyama | Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. {ECO:0000250}. |
| Q15365 | PCBP1 | T142 | Sugiyama | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:15731341, PubMed:7556077, PubMed:7607214, PubMed:8152927). Together with PCBP2, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P60335, ECO:0000269|PubMed:15731341, ECO:0000269|PubMed:7556077, ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. {ECO:0000269|PubMed:12414943}. |
| Q15366 | PCBP2 | T142 | Sugiyama | Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2) | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. |
| Q12851 | MAP4K2 | T26 | Sugiyama | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887, ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:7477268, ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. |
| Q13347 | EIF3I | T205 | Sugiyama | Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36) | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. |
| Q15375 | EPHA7 | T793 | Sugiyama | Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269|PubMed:17726105}. |
| Q5S007 | LRRK2 | T833 | EPSD|PSP | Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:17114044, PubMed:20949042, PubMed:21850687, PubMed:22012985, PubMed:23395371, PubMed:24687852, PubMed:25201882, PubMed:26014385, PubMed:26824392, PubMed:27830463, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43 (PubMed:23395371, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29127255, PubMed:29212815, PubMed:30398148, PubMed:30635421, PubMed:38127736). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:28720718, PubMed:29125462, PubMed:29212815). Recruited by RAB29/RAB7L1 to overloaded lysosomes where it phosphorylates and stabilizes RAB8A and RAB10 which promote lysosomal content release and suppress lysosomal enlargement through the EHBP1 and EHBP1L1 effector proteins (PubMed:30209220, PubMed:38227290). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421, ECO:0000269|PubMed:38127736, ECO:0000269|PubMed:38227290}. |
| Q9H4B4 | PLK3 | T82 | Sugiyama | Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) | Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269|PubMed:10557092, ECO:0000269|PubMed:11156373, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:11971976, ECO:0000269|PubMed:12242661, ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:15021912, ECO:0000269|PubMed:16478733, ECO:0000269|PubMed:16481012, ECO:0000269|PubMed:17264206, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:18062778, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21376736, ECO:0000269|PubMed:21840391, ECO:0000269|PubMed:9353331}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-437239 | Recycling pathway of L1 | 7.427281e-12 | 11.129 |
| R-HSA-422475 | Axon guidance | 5.365153e-12 | 11.270 |
| R-HSA-9675108 | Nervous system development | 1.889955e-11 | 10.724 |
| R-HSA-2262752 | Cellular responses to stress | 5.187550e-11 | 10.285 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 2.584536e-10 | 9.588 |
| R-HSA-8953897 | Cellular responses to stimuli | 7.629486e-10 | 9.118 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 2.095773e-09 | 8.679 |
| R-HSA-373760 | L1CAM interactions | 1.943777e-09 | 8.711 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 3.513076e-09 | 8.454 |
| R-HSA-190828 | Gap junction trafficking | 3.615291e-09 | 8.442 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 6.060040e-09 | 8.218 |
| R-HSA-157858 | Gap junction trafficking and regulation | 7.326560e-09 | 8.135 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 1.233188e-08 | 7.909 |
| R-HSA-9833482 | PKR-mediated signaling | 1.228282e-08 | 7.911 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 1.601251e-08 | 7.796 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 2.611748e-08 | 7.583 |
| R-HSA-3371556 | Cellular response to heat stress | 3.751929e-08 | 7.426 |
| R-HSA-3371568 | Attenuation phase | 4.414854e-08 | 7.355 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 6.224134e-08 | 7.206 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 8.814251e-08 | 7.055 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 1.012497e-07 | 6.995 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 1.268706e-07 | 6.897 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 1.268706e-07 | 6.897 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 1.572417e-07 | 6.803 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.028075e-07 | 6.693 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 3.139085e-07 | 6.503 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 3.430829e-07 | 6.465 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 3.484086e-07 | 6.458 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.809209e-07 | 6.419 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 4.115266e-07 | 6.386 |
| R-HSA-9663891 | Selective autophagy | 4.115266e-07 | 6.386 |
| R-HSA-190861 | Gap junction assembly | 4.651664e-07 | 6.332 |
| R-HSA-391251 | Protein folding | 5.981659e-07 | 6.223 |
| R-HSA-9646399 | Aggrephagy | 1.021194e-06 | 5.991 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.296893e-06 | 5.887 |
| R-HSA-5617833 | Cilium Assembly | 1.953311e-06 | 5.709 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 2.108347e-06 | 5.676 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 3.698672e-06 | 5.432 |
| R-HSA-9612973 | Autophagy | 3.492986e-06 | 5.457 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.679317e-06 | 5.330 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 6.413281e-06 | 5.193 |
| R-HSA-2682334 | EPH-Ephrin signaling | 7.364175e-06 | 5.133 |
| R-HSA-983189 | Kinesins | 8.342126e-06 | 5.079 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 9.818047e-06 | 5.008 |
| R-HSA-3371511 | HSF1 activation | 1.316179e-05 | 4.881 |
| R-HSA-1632852 | Macroautophagy | 1.447764e-05 | 4.839 |
| R-HSA-68877 | Mitotic Prometaphase | 1.668167e-05 | 4.778 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 2.539867e-05 | 4.595 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 3.509837e-05 | 4.455 |
| R-HSA-2467813 | Separation of Sister Chromatids | 3.922313e-05 | 4.406 |
| R-HSA-1266738 | Developmental Biology | 4.272080e-05 | 4.369 |
| R-HSA-5620924 | Intraflagellar transport | 4.596185e-05 | 4.338 |
| R-HSA-199991 | Membrane Trafficking | 5.289053e-05 | 4.277 |
| R-HSA-438064 | Post NMDA receptor activation events | 5.661158e-05 | 4.247 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 7.718158e-05 | 4.112 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.880463e-05 | 4.103 |
| R-HSA-9764561 | Regulation of CDH1 Function | 9.224117e-05 | 4.035 |
| R-HSA-69275 | G2/M Transition | 8.933233e-05 | 4.049 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 9.547145e-05 | 4.020 |
| R-HSA-9841251 | Mitochondrial unfolded protein response (UPRmt) | 8.562188e-05 | 4.067 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 1.021690e-04 | 3.991 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 1.021690e-04 | 3.991 |
| R-HSA-913531 | Interferon Signaling | 1.078158e-04 | 3.967 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 1.209687e-04 | 3.917 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.245691e-04 | 3.905 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 1.401098e-04 | 3.854 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.371426e-04 | 3.863 |
| R-HSA-68882 | Mitotic Anaphase | 2.316713e-04 | 3.635 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 2.383044e-04 | 3.623 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 3.225681e-04 | 3.491 |
| R-HSA-2132295 | MHC class II antigen presentation | 3.817988e-04 | 3.418 |
| R-HSA-109582 | Hemostasis | 3.935925e-04 | 3.405 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 3.974791e-04 | 3.401 |
| R-HSA-8854214 | TBC/RABGAPs | 4.445741e-04 | 3.352 |
| R-HSA-114608 | Platelet degranulation | 4.606178e-04 | 3.337 |
| R-HSA-68886 | M Phase | 4.639539e-04 | 3.334 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.338475e-04 | 3.273 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 5.609692e-04 | 3.251 |
| R-HSA-156902 | Peptide chain elongation | 5.746175e-04 | 3.241 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.916653e-04 | 3.228 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 6.295475e-04 | 3.201 |
| R-HSA-373753 | Nephrin family interactions | 7.133076e-04 | 3.147 |
| R-HSA-5358351 | Signaling by Hedgehog | 7.255767e-04 | 3.139 |
| R-HSA-9609690 | HCMV Early Events | 7.264444e-04 | 3.139 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.532067e-04 | 3.069 |
| R-HSA-9854909 | Regulation of MITF-M dependent genes involved in invasion | 1.098003e-03 | 2.959 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 1.030276e-03 | 2.987 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 9.996266e-04 | 3.000 |
| R-HSA-1640170 | Cell Cycle | 1.457693e-03 | 2.836 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.471701e-03 | 2.832 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.471701e-03 | 2.832 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.504701e-03 | 2.823 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.504701e-03 | 2.823 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.748121e-03 | 2.757 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 1.924804e-03 | 2.716 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 2.081481e-03 | 2.682 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 2.081481e-03 | 2.682 |
| R-HSA-1500931 | Cell-Cell communication | 2.237065e-03 | 2.650 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.333894e-03 | 2.632 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 2.419905e-03 | 2.616 |
| R-HSA-196025 | Formation of annular gap junctions | 2.663553e-03 | 2.575 |
| R-HSA-9613354 | Lipophagy | 3.155791e-03 | 2.501 |
| R-HSA-190873 | Gap junction degradation | 3.155791e-03 | 2.501 |
| R-HSA-380287 | Centrosome maturation | 2.640366e-03 | 2.578 |
| R-HSA-428543 | Inactivation of CDC42 and RAC1 | 3.155791e-03 | 2.501 |
| R-HSA-9609646 | HCMV Infection | 2.639663e-03 | 2.578 |
| R-HSA-9659379 | Sensory processing of sound | 3.121916e-03 | 2.506 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 3.540827e-03 | 2.451 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 3.687254e-03 | 2.433 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.804049e-03 | 2.420 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 4.252450e-03 | 2.371 |
| R-HSA-376176 | Signaling by ROBO receptors | 4.345515e-03 | 2.362 |
| R-HSA-5674135 | MAP2K and MAPK activation | 4.771564e-03 | 2.321 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 4.771564e-03 | 2.321 |
| R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes | 4.865678e-03 | 2.313 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 5.094707e-03 | 2.293 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 5.274238e-03 | 2.278 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 5.360952e-03 | 2.271 |
| R-HSA-8953854 | Metabolism of RNA | 5.723957e-03 | 2.242 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.034709e-03 | 2.219 |
| R-HSA-192823 | Viral mRNA Translation | 8.004820e-03 | 2.097 |
| R-HSA-72764 | Eukaryotic Translation Termination | 6.235625e-03 | 2.205 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 6.231550e-03 | 2.205 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 6.231550e-03 | 2.205 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 6.231550e-03 | 2.205 |
| R-HSA-6802949 | Signaling by RAS mutants | 6.231550e-03 | 2.205 |
| R-HSA-8876725 | Protein methylation | 7.669536e-03 | 2.115 |
| R-HSA-2408557 | Selenocysteine synthesis | 7.534988e-03 | 2.123 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 6.906177e-03 | 2.161 |
| R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones | 6.194513e-03 | 2.208 |
| R-HSA-70171 | Glycolysis | 7.307053e-03 | 2.136 |
| R-HSA-70263 | Gluconeogenesis | 6.882092e-03 | 2.162 |
| R-HSA-112316 | Neuronal System | 6.503309e-03 | 2.187 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.673696e-03 | 2.115 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 8.246792e-03 | 2.084 |
| R-HSA-2408522 | Selenoamino acid metabolism | 8.483675e-03 | 2.071 |
| R-HSA-445355 | Smooth Muscle Contraction | 8.679834e-03 | 2.061 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 9.262588e-03 | 2.033 |
| R-HSA-112315 | Transmission across Chemical Synapses | 9.429014e-03 | 2.026 |
| R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 9.878460e-03 | 2.005 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 1.051179e-02 | 1.978 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 1.051179e-02 | 1.978 |
| R-HSA-1474244 | Extracellular matrix organization | 1.060433e-02 | 1.975 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.064279e-02 | 1.973 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.064279e-02 | 1.973 |
| R-HSA-168255 | Influenza Infection | 1.187623e-02 | 1.925 |
| R-HSA-72766 | Translation | 1.228913e-02 | 1.910 |
| R-HSA-9007101 | Rab regulation of trafficking | 1.278873e-02 | 1.893 |
| R-HSA-70326 | Glucose metabolism | 1.278873e-02 | 1.893 |
| R-HSA-5602566 | TICAM1 deficiency - HSE | 1.356999e-02 | 1.867 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.392434e-02 | 1.856 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 1.402932e-02 | 1.853 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.586993e-02 | 1.799 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 1.600718e-02 | 1.796 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.638566e-02 | 1.786 |
| R-HSA-446728 | Cell junction organization | 1.684284e-02 | 1.774 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.709236e-02 | 1.767 |
| R-HSA-5602571 | TRAF3 deficiency - HSE | 2.028639e-02 | 1.693 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 2.028639e-02 | 1.693 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 2.153274e-02 | 1.667 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 2.175064e-02 | 1.663 |
| R-HSA-9948299 | Ribosome-associated quality control | 2.216527e-02 | 1.654 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 2.262694e-02 | 1.645 |
| R-HSA-418990 | Adherens junctions interactions | 2.412391e-02 | 1.618 |
| R-HSA-9615710 | Late endosomal microautophagy | 2.425301e-02 | 1.615 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 2.425301e-02 | 1.615 |
| R-HSA-9824446 | Viral Infection Pathways | 2.481543e-02 | 1.605 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.632164e-02 | 1.580 |
| R-HSA-8874177 | ATF6B (ATF6-beta) activates chaperones | 2.695748e-02 | 1.569 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 2.971078e-02 | 1.527 |
| R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death | 4.016491e-02 | 1.396 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.660154e-02 | 1.437 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 3.241741e-02 | 1.489 |
| R-HSA-6798695 | Neutrophil degranulation | 4.606129e-02 | 1.337 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 4.121374e-02 | 1.385 |
| R-HSA-9711097 | Cellular response to starvation | 3.310625e-02 | 1.480 |
| R-HSA-392499 | Metabolism of proteins | 3.771608e-02 | 1.423 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 4.471322e-02 | 1.350 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.243582e-02 | 1.489 |
| R-HSA-421270 | Cell-cell junction organization | 3.882671e-02 | 1.411 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.765971e-02 | 1.322 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 4.964549e-02 | 1.304 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 4.970273e-02 | 1.304 |
| R-HSA-9824272 | Somitogenesis | 5.140878e-02 | 1.289 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 5.313567e-02 | 1.275 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 5.319468e-02 | 1.274 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 5.414191e-02 | 1.266 |
| R-HSA-162582 | Signal Transduction | 5.600654e-02 | 1.252 |
| R-HSA-168256 | Immune System | 5.704639e-02 | 1.244 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 5.964368e-02 | 1.224 |
| R-HSA-199920 | CREB phosphorylation | 5.964368e-02 | 1.224 |
| R-HSA-72187 | mRNA 3'-end processing | 6.391487e-02 | 1.194 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 6.604916e-02 | 1.180 |
| R-HSA-1296052 | Ca2+ activated K+ channels | 6.604916e-02 | 1.180 |
| R-HSA-447041 | CHL1 interactions | 6.604916e-02 | 1.180 |
| R-HSA-72649 | Translation initiation complex formation | 6.765889e-02 | 1.170 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 7.147396e-02 | 1.146 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 7.241139e-02 | 1.140 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 7.340732e-02 | 1.134 |
| R-HSA-5663205 | Infectious disease | 7.386263e-02 | 1.132 |
| R-HSA-397014 | Muscle contraction | 7.533110e-02 | 1.123 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 7.535748e-02 | 1.123 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 7.625495e-02 | 1.118 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 8.500730e-02 | 1.071 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 9.743370e-02 | 1.011 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 1.217870e-01 | 0.914 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 1.217870e-01 | 0.914 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.277729e-01 | 0.894 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 1.396236e-01 | 0.855 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.513148e-01 | 0.820 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 1.571012e-01 | 0.804 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 1.064205e-01 | 0.973 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 1.264351e-01 | 0.898 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.355991e-01 | 0.868 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.355991e-01 | 0.868 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 9.743370e-02 | 1.011 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 1.337183e-01 | 0.874 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 1.571012e-01 | 0.804 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.337183e-01 | 0.874 |
| R-HSA-176974 | Unwinding of DNA | 7.873068e-02 | 1.104 |
| R-HSA-177135 | Conjugation of benzoate with glycine | 9.124155e-02 | 1.040 |
| R-HSA-177128 | Conjugation of salicylate with glycine | 1.035840e-01 | 0.985 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.096929e-01 | 0.960 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 1.454890e-01 | 0.837 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 8.130564e-02 | 1.090 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.332940e-01 | 0.875 |
| R-HSA-8873719 | RAB geranylgeranylation | 7.930695e-02 | 1.101 |
| R-HSA-428359 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RN... | 8.500730e-02 | 1.071 |
| R-HSA-9706019 | RHOBTB3 ATPase cycle | 9.124155e-02 | 1.040 |
| R-HSA-159424 | Conjugation of carboxylic acids | 1.513148e-01 | 0.820 |
| R-HSA-156587 | Amino Acid conjugation | 1.513148e-01 | 0.820 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 9.862746e-02 | 1.006 |
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | 1.217870e-01 | 0.914 |
| R-HSA-1566977 | Fibronectin matrix formation | 1.337183e-01 | 0.874 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 1.042541e-01 | 0.982 |
| R-HSA-5683057 | MAPK family signaling cascades | 1.074349e-01 | 0.969 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 1.157604e-01 | 0.936 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 1.157604e-01 | 0.936 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.217870e-01 | 0.914 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.571012e-01 | 0.804 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.157604e-01 | 0.936 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 1.396236e-01 | 0.855 |
| R-HSA-9828642 | Respiratory syncytial virus genome transcription | 1.157604e-01 | 0.936 |
| R-HSA-72312 | rRNA processing | 9.487930e-02 | 1.023 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.277729e-01 | 0.894 |
| R-HSA-391908 | Prostanoid ligand receptors | 9.124155e-02 | 1.040 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 1.277729e-01 | 0.894 |
| R-HSA-69620 | Cell Cycle Checkpoints | 1.234822e-01 | 0.908 |
| R-HSA-9629569 | Protein hydroxylation | 1.571012e-01 | 0.804 |
| R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs | 1.454890e-01 | 0.837 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 8.130564e-02 | 1.090 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 1.571012e-01 | 0.804 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.084163e-01 | 0.965 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.085991e-01 | 0.964 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 8.945306e-02 | 1.048 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 1.477731e-01 | 0.830 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 1.379131e-01 | 0.860 |
| R-HSA-9020591 | Interleukin-12 signaling | 1.129917e-01 | 0.947 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 8.374348e-02 | 1.077 |
| R-HSA-447115 | Interleukin-12 family signaling | 1.402359e-01 | 0.853 |
| R-HSA-198753 | ERK/MAPK targets | 1.628485e-01 | 0.788 |
| R-HSA-597592 | Post-translational protein modification | 1.711524e-01 | 0.767 |
| R-HSA-9614085 | FOXO-mediated transcription | 1.735548e-01 | 0.761 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 1.759837e-01 | 0.755 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.790428e-01 | 0.747 |
| R-HSA-3000170 | Syndecan interactions | 1.798584e-01 | 0.745 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 1.854520e-01 | 0.732 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 1.854520e-01 | 0.732 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 1.906655e-01 | 0.720 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 1.910077e-01 | 0.719 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 1.910077e-01 | 0.719 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.965259e-01 | 0.707 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 1.965259e-01 | 0.707 |
| R-HSA-72172 | mRNA Splicing | 1.979162e-01 | 0.704 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 1.980684e-01 | 0.703 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 2.005440e-01 | 0.698 |
| R-HSA-201451 | Signaling by BMP | 2.020067e-01 | 0.695 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 2.030234e-01 | 0.692 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 2.030234e-01 | 0.692 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 2.104822e-01 | 0.677 |
| R-HSA-168249 | Innate Immune System | 2.109238e-01 | 0.676 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 2.128576e-01 | 0.672 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.179690e-01 | 0.662 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 2.182281e-01 | 0.661 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.182281e-01 | 0.661 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 2.182281e-01 | 0.661 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 2.204700e-01 | 0.657 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 2.235622e-01 | 0.651 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 2.235622e-01 | 0.651 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 2.235622e-01 | 0.651 |
| R-HSA-69190 | DNA strand elongation | 2.288603e-01 | 0.640 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 2.341226e-01 | 0.631 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 2.341226e-01 | 0.631 |
| R-HSA-354192 | Integrin signaling | 2.341226e-01 | 0.631 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 2.341226e-01 | 0.631 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 2.341226e-01 | 0.631 |
| R-HSA-9930044 | Nuclear RNA decay | 2.341226e-01 | 0.631 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.391019e-01 | 0.621 |
| R-HSA-390522 | Striated Muscle Contraction | 2.393492e-01 | 0.621 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 2.393492e-01 | 0.621 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 2.393492e-01 | 0.621 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 2.393492e-01 | 0.621 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 2.393492e-01 | 0.621 |
| R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | 2.393492e-01 | 0.621 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 2.445406e-01 | 0.612 |
| R-HSA-180746 | Nuclear import of Rev protein | 2.445406e-01 | 0.612 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 2.445406e-01 | 0.612 |
| R-HSA-194138 | Signaling by VEGF | 2.481134e-01 | 0.605 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.496968e-01 | 0.603 |
| R-HSA-381042 | PERK regulates gene expression | 2.496968e-01 | 0.603 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 2.548181e-01 | 0.594 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 2.548181e-01 | 0.594 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 2.548181e-01 | 0.594 |
| R-HSA-163560 | Triglyceride catabolism | 2.548181e-01 | 0.594 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 2.569817e-01 | 0.590 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 2.599048e-01 | 0.585 |
| R-HSA-157118 | Signaling by NOTCH | 2.624835e-01 | 0.581 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 2.649571e-01 | 0.577 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 2.699752e-01 | 0.569 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 2.699752e-01 | 0.569 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 2.699752e-01 | 0.569 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 2.699752e-01 | 0.569 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 2.749594e-01 | 0.561 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 2.749594e-01 | 0.561 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 2.749594e-01 | 0.561 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 2.749594e-01 | 0.561 |
| R-HSA-5260271 | Diseases of Immune System | 2.749594e-01 | 0.561 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 2.799099e-01 | 0.553 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 2.848268e-01 | 0.545 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 2.848268e-01 | 0.545 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 2.897105e-01 | 0.538 |
| R-HSA-9664407 | Parasite infection | 2.910070e-01 | 0.536 |
| R-HSA-9664417 | Leishmania phagocytosis | 2.910070e-01 | 0.536 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 2.910070e-01 | 0.536 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 2.935263e-01 | 0.532 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.945611e-01 | 0.531 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 3.041641e-01 | 0.517 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 3.041641e-01 | 0.517 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 3.041641e-01 | 0.517 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 3.041641e-01 | 0.517 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 3.041641e-01 | 0.517 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 3.041641e-01 | 0.517 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 3.041641e-01 | 0.517 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.050761e-01 | 0.516 |
| R-HSA-1280218 | Adaptive Immune System | 3.058462e-01 | 0.514 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 3.089169e-01 | 0.510 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.136317e-01 | 0.504 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 3.136376e-01 | 0.504 |
| R-HSA-9711123 | Cellular response to chemical stress | 3.143954e-01 | 0.503 |
| R-HSA-9758941 | Gastrulation | 3.161374e-01 | 0.500 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.367657e-01 | 0.473 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.367657e-01 | 0.473 |
| R-HSA-6794361 | Neurexins and neuroligins | 3.367657e-01 | 0.473 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 3.412978e-01 | 0.467 |
| R-HSA-1221632 | Meiotic synapsis | 3.412978e-01 | 0.467 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 3.412978e-01 | 0.467 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 3.457992e-01 | 0.461 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.535635e-01 | 0.452 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 3.591214e-01 | 0.445 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 3.665833e-01 | 0.436 |
| R-HSA-191859 | snRNP Assembly | 3.678531e-01 | 0.434 |
| R-HSA-194441 | Metabolism of non-coding RNA | 3.678531e-01 | 0.434 |
| R-HSA-9033241 | Peroxisomal protein import | 3.678531e-01 | 0.434 |
| R-HSA-8979227 | Triglyceride metabolism | 3.678531e-01 | 0.434 |
| R-HSA-72306 | tRNA processing | 3.706160e-01 | 0.431 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 3.721747e-01 | 0.429 |
| R-HSA-379724 | tRNA Aminoacylation | 3.721747e-01 | 0.429 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.764669e-01 | 0.424 |
| R-HSA-450294 | MAP kinase activation | 3.764669e-01 | 0.424 |
| R-HSA-445717 | Aquaporin-mediated transport | 3.764669e-01 | 0.424 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 3.803531e-01 | 0.420 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.807301e-01 | 0.419 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.807301e-01 | 0.419 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.849644e-01 | 0.415 |
| R-HSA-8848021 | Signaling by PTK6 | 3.849644e-01 | 0.415 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 3.849644e-01 | 0.415 |
| R-HSA-373755 | Semaphorin interactions | 3.849644e-01 | 0.415 |
| R-HSA-6782315 | tRNA modification in the nucleus and cytosol | 3.974960e-01 | 0.401 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 4.097680e-01 | 0.387 |
| R-HSA-448424 | Interleukin-17 signaling | 4.138119e-01 | 0.383 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 4.138119e-01 | 0.383 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 4.178220e-01 | 0.379 |
| R-HSA-5632684 | Hedgehog 'on' state | 4.178220e-01 | 0.379 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 4.178220e-01 | 0.379 |
| R-HSA-168898 | Toll-like Receptor Cascades | 4.209971e-01 | 0.376 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 4.218049e-01 | 0.375 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 4.218049e-01 | 0.375 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 4.218049e-01 | 0.375 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 4.218049e-01 | 0.375 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 4.233472e-01 | 0.373 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 4.257609e-01 | 0.371 |
| R-HSA-9749641 | Aspirin ADME | 4.257609e-01 | 0.371 |
| R-HSA-1226099 | Signaling by FGFR in disease | 4.296900e-01 | 0.367 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 4.335924e-01 | 0.363 |
| R-HSA-5689603 | UCH proteinases | 4.374684e-01 | 0.359 |
| R-HSA-1980143 | Signaling by NOTCH1 | 4.374684e-01 | 0.359 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 4.435107e-01 | 0.353 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 4.527113e-01 | 0.344 |
| R-HSA-449147 | Signaling by Interleukins | 4.528869e-01 | 0.344 |
| R-HSA-977225 | Amyloid fiber formation | 4.564576e-01 | 0.341 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 4.675448e-01 | 0.330 |
| R-HSA-1500620 | Meiosis | 4.711905e-01 | 0.327 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 4.711905e-01 | 0.327 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 4.784078e-01 | 0.320 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 4.784078e-01 | 0.320 |
| R-HSA-1643685 | Disease | 4.887855e-01 | 0.311 |
| R-HSA-112310 | Neurotransmitter release cycle | 4.925509e-01 | 0.308 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 5.001208e-01 | 0.301 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 5.063139e-01 | 0.296 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 5.065951e-01 | 0.295 |
| R-HSA-9837999 | Mitochondrial protein degradation | 5.096965e-01 | 0.293 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 5.130561e-01 | 0.290 |
| R-HSA-1296071 | Potassium Channels | 5.197070e-01 | 0.284 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 5.232211e-01 | 0.281 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 5.262678e-01 | 0.279 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 5.262678e-01 | 0.279 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 5.262678e-01 | 0.279 |
| R-HSA-3214847 | HATs acetylate histones | 5.295149e-01 | 0.276 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 5.391243e-01 | 0.268 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 5.454223e-01 | 0.263 |
| R-HSA-5696398 | Nucleotide Excision Repair | 5.516350e-01 | 0.258 |
| R-HSA-9679506 | SARS-CoV Infections | 5.570476e-01 | 0.254 |
| R-HSA-69239 | Synthesis of DNA | 5.577635e-01 | 0.254 |
| R-HSA-211000 | Gene Silencing by RNA | 5.577635e-01 | 0.254 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 5.638090e-01 | 0.249 |
| R-HSA-1483249 | Inositol phosphate metabolism | 5.727241e-01 | 0.242 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 5.785669e-01 | 0.238 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 5.984001e-01 | 0.223 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 5.984001e-01 | 0.223 |
| R-HSA-68875 | Mitotic Prophase | 6.011569e-01 | 0.221 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 6.038949e-01 | 0.219 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.038949e-01 | 0.219 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 6.066143e-01 | 0.217 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 6.066143e-01 | 0.217 |
| R-HSA-9824443 | Parasitic Infection Pathways | 6.115971e-01 | 0.214 |
| R-HSA-9658195 | Leishmania infection | 6.115971e-01 | 0.214 |
| R-HSA-162909 | Host Interactions of HIV factors | 6.119977e-01 | 0.213 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 6.134075e-01 | 0.212 |
| R-HSA-69206 | G1/S Transition | 6.173081e-01 | 0.209 |
| R-HSA-69481 | G2/M Checkpoints | 6.225465e-01 | 0.206 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 6.251389e-01 | 0.204 |
| R-HSA-1474165 | Reproduction | 6.328109e-01 | 0.199 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 6.525173e-01 | 0.185 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 6.666059e-01 | 0.176 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 6.666059e-01 | 0.176 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6.756824e-01 | 0.170 |
| R-HSA-69242 | S Phase | 6.801283e-01 | 0.167 |
| R-HSA-166520 | Signaling by NTRKs | 6.801283e-01 | 0.167 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 6.822009e-01 | 0.166 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 6.866843e-01 | 0.163 |
| R-HSA-69306 | DNA Replication | 6.909808e-01 | 0.161 |
| R-HSA-9609507 | Protein localization | 6.909808e-01 | 0.161 |
| R-HSA-9610379 | HCMV Late Events | 6.993993e-01 | 0.155 |
| R-HSA-162587 | HIV Life Cycle | 6.993993e-01 | 0.155 |
| R-HSA-9006936 | Signaling by TGFB family members | 7.055637e-01 | 0.151 |
| R-HSA-5633007 | Regulation of TP53 Activity | 7.055637e-01 | 0.151 |
| R-HSA-109581 | Apoptosis | 7.096036e-01 | 0.149 |
| R-HSA-5619102 | SLC transporter disorders | 7.194645e-01 | 0.143 |
| R-HSA-74160 | Gene expression (Transcription) | 7.199943e-01 | 0.143 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 7.204798e-01 | 0.142 |
| R-HSA-418555 | G alpha (s) signalling events | 7.289935e-01 | 0.137 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 7.289935e-01 | 0.137 |
| R-HSA-73894 | DNA Repair | 7.354825e-01 | 0.133 |
| R-HSA-5357801 | Programmed Cell Death | 7.872887e-01 | 0.104 |
| R-HSA-9748784 | Drug ADME | 8.056157e-01 | 0.094 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 8.122283e-01 | 0.090 |
| R-HSA-162906 | HIV Infection | 8.173781e-01 | 0.088 |
| R-HSA-3247509 | Chromatin modifying enzymes | 8.260366e-01 | 0.083 |
| R-HSA-156580 | Phase II - Conjugation of compounds | 8.319709e-01 | 0.080 |
| R-HSA-73857 | RNA Polymerase II Transcription | 8.402650e-01 | 0.076 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 8.410513e-01 | 0.075 |
| R-HSA-4839726 | Chromatin organization | 8.432443e-01 | 0.074 |
| R-HSA-5688426 | Deubiquitination | 8.496452e-01 | 0.071 |
| R-HSA-212436 | Generic Transcription Pathway | 9.211379e-01 | 0.036 |
| R-HSA-9824439 | Bacterial Infection Pathways | 9.418077e-01 | 0.026 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.434169e-01 | 0.025 |
| R-HSA-9709957 | Sensory Perception | 9.759801e-01 | 0.011 |
| R-HSA-211859 | Biological oxidations | 9.771841e-01 | 0.010 |
| R-HSA-500792 | GPCR ligand binding | 9.857058e-01 | 0.006 |
| R-HSA-388396 | GPCR downstream signalling | 9.961869e-01 | 0.002 |
| R-HSA-372790 | Signaling by GPCR | 9.979032e-01 | 0.001 |
| R-HSA-382551 | Transport of small molecules | 9.991471e-01 | 0.000 |
| R-HSA-1430728 | Metabolism | 9.999094e-01 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 9.999801e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.765 | 0.067 | 1 | 0.802 |
PKR |
0.762 | 0.082 | 1 | 0.789 |
VRK2 |
0.757 | -0.052 | 1 | 0.792 |
VRK1 |
0.755 | -0.013 | 2 | 0.716 |
TNIK |
0.753 | 0.007 | 3 | 0.756 |
MINK |
0.751 | -0.015 | 1 | 0.712 |
MOS |
0.749 | 0.132 | 1 | 0.827 |
TAK1 |
0.748 | -0.078 | 1 | 0.732 |
EEF2K |
0.748 | 0.017 | 3 | 0.723 |
LRRK2 |
0.747 | -0.084 | 2 | 0.734 |
MEKK2 |
0.747 | -0.025 | 2 | 0.681 |
GCK |
0.746 | -0.052 | 1 | 0.731 |
NEK1 |
0.745 | -0.061 | 1 | 0.743 |
BMPR2 |
0.745 | -0.081 | -2 | 0.731 |
NEK5 |
0.744 | -0.050 | 1 | 0.769 |
MPSK1 |
0.743 | 0.044 | 1 | 0.737 |
OSR1 |
0.743 | -0.033 | 2 | 0.671 |
BRAF |
0.743 | -0.116 | -4 | 0.559 |
MEK1 |
0.742 | -0.106 | 2 | 0.679 |
MST2 |
0.742 | -0.080 | 1 | 0.735 |
ALPHAK3 |
0.742 | -0.042 | -1 | 0.638 |
KHS1 |
0.741 | -0.033 | 1 | 0.703 |
MST3 |
0.741 | 0.019 | 2 | 0.694 |
LKB1 |
0.741 | -0.078 | -3 | 0.737 |
TTK |
0.741 | -0.050 | -2 | 0.682 |
KHS2 |
0.741 | -0.005 | 1 | 0.714 |
BIKE |
0.741 | 0.026 | 1 | 0.701 |
ALK4 |
0.741 | -0.032 | -2 | 0.634 |
NIK |
0.740 | -0.081 | -3 | 0.744 |
HGK |
0.740 | -0.056 | 3 | 0.730 |
PRPK |
0.740 | -0.037 | -1 | 0.685 |
PDK1 |
0.740 | -0.094 | 1 | 0.707 |
MAP3K15 |
0.740 | -0.075 | 1 | 0.659 |
MYO3B |
0.739 | -0.022 | 2 | 0.715 |
CAMKK2 |
0.739 | -0.118 | -2 | 0.611 |
TAO3 |
0.739 | -0.058 | 1 | 0.705 |
ASK1 |
0.739 | -0.123 | 1 | 0.639 |
DAPK2 |
0.739 | -0.064 | -3 | 0.728 |
MEKK6 |
0.739 | -0.043 | 1 | 0.729 |
PASK |
0.739 | -0.019 | -3 | 0.736 |
TGFBR1 |
0.738 | 0.024 | -2 | 0.608 |
CAMKK1 |
0.738 | -0.123 | -2 | 0.625 |
BMPR1B |
0.738 | 0.082 | 1 | 0.803 |
HPK1 |
0.738 | -0.043 | 1 | 0.715 |
MEK5 |
0.738 | -0.181 | 2 | 0.681 |
MEKK1 |
0.738 | -0.089 | 1 | 0.713 |
ANKRD3 |
0.737 | -0.079 | 1 | 0.775 |
PRP4 |
0.737 | 0.063 | -3 | 0.773 |
DLK |
0.737 | -0.085 | 1 | 0.749 |
MEKK3 |
0.737 | -0.032 | 1 | 0.727 |
ACVR2B |
0.737 | 0.058 | -2 | 0.627 |
TAO2 |
0.736 | -0.112 | 2 | 0.721 |
CAMLCK |
0.736 | -0.063 | -2 | 0.685 |
GRK7 |
0.736 | 0.060 | 1 | 0.733 |
NEK4 |
0.735 | -0.083 | 1 | 0.722 |
ALK2 |
0.735 | -0.007 | -2 | 0.607 |
MST1 |
0.735 | -0.131 | 1 | 0.714 |
LATS1 |
0.734 | -0.022 | -3 | 0.713 |
GRK6 |
0.734 | 0.076 | 1 | 0.794 |
ERK5 |
0.734 | 0.143 | 1 | 0.836 |
MYO3A |
0.734 | -0.079 | 1 | 0.713 |
PBK |
0.733 | -0.012 | 1 | 0.745 |
CHAK2 |
0.733 | 0.074 | -1 | 0.707 |
NLK |
0.733 | -0.005 | 1 | 0.740 |
YSK1 |
0.733 | -0.059 | 2 | 0.715 |
COT |
0.733 | 0.135 | 2 | 0.717 |
CAMK1B |
0.733 | -0.040 | -3 | 0.718 |
ACVR2A |
0.732 | 0.031 | -2 | 0.604 |
JNK3 |
0.732 | 0.004 | 1 | 0.569 |
JNK2 |
0.731 | 0.015 | 1 | 0.536 |
AAK1 |
0.731 | 0.056 | 1 | 0.614 |
CDKL1 |
0.731 | -0.005 | -3 | 0.669 |
NEK11 |
0.731 | -0.110 | 1 | 0.698 |
TLK2 |
0.731 | -0.019 | 1 | 0.710 |
PLK1 |
0.731 | 0.030 | -2 | 0.704 |
P38A |
0.731 | 0.026 | 1 | 0.660 |
NEK8 |
0.730 | -0.136 | 2 | 0.700 |
GRK5 |
0.730 | 0.026 | -3 | 0.792 |
SKMLCK |
0.730 | -0.002 | -2 | 0.718 |
ATR |
0.728 | -0.065 | 1 | 0.748 |
CAMK2G |
0.727 | 0.001 | 2 | 0.688 |
GRK1 |
0.727 | 0.153 | -2 | 0.627 |
YSK4 |
0.726 | -0.096 | 1 | 0.680 |
P38B |
0.726 | 0.017 | 1 | 0.600 |
DAPK3 |
0.726 | -0.062 | -3 | 0.656 |
HASPIN |
0.726 | 0.040 | -1 | 0.626 |
WNK4 |
0.726 | -0.038 | -2 | 0.742 |
MEK2 |
0.725 | -0.217 | 2 | 0.684 |
ICK |
0.725 | -0.041 | -3 | 0.702 |
BMPR1A |
0.725 | 0.040 | 1 | 0.768 |
WNK1 |
0.724 | 0.031 | -2 | 0.749 |
PERK |
0.724 | -0.098 | -2 | 0.641 |
NEK9 |
0.724 | -0.044 | 2 | 0.738 |
MLK1 |
0.723 | -0.012 | 2 | 0.679 |
TLK1 |
0.723 | -0.054 | -2 | 0.706 |
ZAK |
0.723 | -0.141 | 1 | 0.674 |
RAF1 |
0.723 | -0.110 | 1 | 0.766 |
GRK2 |
0.723 | 0.065 | -2 | 0.639 |
STLK3 |
0.722 | -0.188 | 1 | 0.644 |
MLK2 |
0.721 | -0.104 | 2 | 0.679 |
BUB1 |
0.721 | 0.047 | -5 | 0.773 |
JNK1 |
0.721 | 0.007 | 1 | 0.526 |
RIPK1 |
0.720 | -0.082 | 1 | 0.757 |
ROCK2 |
0.720 | -0.059 | -3 | 0.638 |
LOK |
0.719 | -0.116 | -2 | 0.622 |
SMMLCK |
0.719 | -0.107 | -3 | 0.671 |
CDC7 |
0.718 | 0.045 | 1 | 0.807 |
DAPK1 |
0.718 | -0.052 | -3 | 0.651 |
ERK7 |
0.717 | 0.093 | 2 | 0.541 |
P38G |
0.717 | 0.010 | 1 | 0.473 |
HIPK1 |
0.717 | 0.002 | 1 | 0.654 |
CDKL5 |
0.716 | 0.053 | -3 | 0.656 |
NEK2 |
0.716 | -0.061 | 2 | 0.718 |
TSSK2 |
0.716 | -0.016 | -5 | 0.794 |
PDHK4 |
0.716 | -0.200 | 1 | 0.766 |
MAK |
0.716 | 0.025 | -2 | 0.612 |
MASTL |
0.716 | -0.181 | -2 | 0.683 |
HRI |
0.715 | -0.155 | -2 | 0.678 |
DMPK1 |
0.715 | -0.067 | -3 | 0.600 |
IRAK4 |
0.715 | -0.068 | 1 | 0.750 |
MST4 |
0.715 | 0.023 | 2 | 0.725 |
MLK3 |
0.715 | -0.011 | 2 | 0.619 |
CK1A2 |
0.714 | 0.192 | -3 | 0.636 |
ERK1 |
0.714 | 0.009 | 1 | 0.575 |
MLK4 |
0.713 | -0.034 | 2 | 0.610 |
CK1D |
0.713 | 0.173 | -3 | 0.639 |
RIPK3 |
0.713 | -0.059 | 3 | 0.596 |
CLK3 |
0.713 | 0.026 | 1 | 0.758 |
NEK3 |
0.713 | -0.084 | 1 | 0.667 |
PKN3 |
0.713 | -0.045 | -3 | 0.690 |
DSTYK |
0.713 | -0.053 | 2 | 0.728 |
NUAK2 |
0.712 | 0.010 | -3 | 0.696 |
ERK2 |
0.712 | -0.041 | 1 | 0.610 |
TAO1 |
0.711 | -0.126 | 1 | 0.622 |
GSK3A |
0.711 | 0.011 | 4 | 0.420 |
AMPKA1 |
0.711 | -0.046 | -3 | 0.707 |
GSK3B |
0.710 | -0.007 | 4 | 0.406 |
SLK |
0.710 | -0.114 | -2 | 0.576 |
MOK |
0.710 | 0.010 | 1 | 0.735 |
P38D |
0.710 | 0.002 | 1 | 0.477 |
PDHK1 |
0.710 | -0.191 | 1 | 0.743 |
CDK5 |
0.709 | -0.003 | 1 | 0.611 |
PIM1 |
0.709 | -0.027 | -3 | 0.645 |
MTOR |
0.709 | -0.045 | 1 | 0.700 |
PLK3 |
0.709 | -0.056 | 2 | 0.632 |
CDK1 |
0.708 | -0.000 | 1 | 0.562 |
DYRK2 |
0.708 | -0.008 | 1 | 0.648 |
NEK6 |
0.708 | -0.013 | -2 | 0.758 |
PIM3 |
0.708 | -0.044 | -3 | 0.706 |
PKCD |
0.707 | -0.047 | 2 | 0.670 |
TSSK1 |
0.707 | -0.020 | -3 | 0.729 |
GRK3 |
0.707 | 0.085 | -2 | 0.599 |
NEK7 |
0.707 | -0.089 | -3 | 0.727 |
IRE1 |
0.706 | -0.021 | 1 | 0.756 |
PKN2 |
0.706 | -0.041 | -3 | 0.694 |
PLK2 |
0.706 | -0.002 | -3 | 0.740 |
HUNK |
0.706 | -0.073 | 2 | 0.647 |
TTBK2 |
0.706 | -0.069 | 2 | 0.634 |
ULK2 |
0.706 | -0.098 | 2 | 0.682 |
HIPK4 |
0.706 | 0.020 | 1 | 0.728 |
GRK4 |
0.705 | -0.012 | -2 | 0.704 |
CHAK1 |
0.705 | -0.099 | 2 | 0.656 |
DCAMKL1 |
0.705 | -0.086 | -3 | 0.634 |
ATM |
0.704 | -0.049 | 1 | 0.688 |
HIPK3 |
0.704 | -0.027 | 1 | 0.652 |
DNAPK |
0.704 | -0.048 | 1 | 0.602 |
SMG1 |
0.704 | -0.065 | 1 | 0.696 |
WNK3 |
0.703 | -0.153 | 1 | 0.734 |
CK1E |
0.703 | 0.178 | -3 | 0.680 |
ROCK1 |
0.703 | -0.075 | -3 | 0.596 |
SGK3 |
0.703 | -0.038 | -3 | 0.615 |
MARK4 |
0.702 | -0.073 | 4 | 0.692 |
PIM2 |
0.702 | -0.043 | -3 | 0.591 |
IKKB |
0.702 | -0.007 | -2 | 0.662 |
TBK1 |
0.701 | -0.099 | 1 | 0.641 |
CK2A2 |
0.701 | 0.073 | 1 | 0.700 |
CAMK2D |
0.701 | -0.057 | -3 | 0.690 |
DRAK1 |
0.701 | -0.098 | 1 | 0.726 |
IRAK1 |
0.701 | -0.152 | -1 | 0.611 |
CHK1 |
0.700 | -0.091 | -3 | 0.661 |
SRPK1 |
0.700 | 0.012 | -3 | 0.628 |
P70S6KB |
0.699 | -0.080 | -3 | 0.640 |
TGFBR2 |
0.699 | -0.095 | -2 | 0.601 |
AMPKA2 |
0.699 | -0.048 | -3 | 0.665 |
CDK2 |
0.699 | -0.022 | 1 | 0.641 |
PKCZ |
0.699 | -0.043 | 2 | 0.684 |
PINK1 |
0.699 | -0.211 | 1 | 0.747 |
IKKA |
0.699 | 0.008 | -2 | 0.678 |
MRCKB |
0.698 | -0.068 | -3 | 0.581 |
CAMK2B |
0.698 | -0.018 | 2 | 0.652 |
CRIK |
0.698 | -0.057 | -3 | 0.549 |
SRPK3 |
0.697 | -0.020 | -3 | 0.608 |
IKKE |
0.697 | -0.092 | 1 | 0.631 |
CDK3 |
0.697 | 0.015 | 1 | 0.501 |
PAK1 |
0.696 | -0.079 | -2 | 0.619 |
CDK13 |
0.696 | -0.019 | 1 | 0.562 |
MYLK4 |
0.695 | -0.073 | -2 | 0.602 |
DYRK1A |
0.695 | -0.052 | 1 | 0.647 |
PKCB |
0.695 | -0.018 | 2 | 0.624 |
HIPK2 |
0.695 | 0.004 | 1 | 0.554 |
CDK12 |
0.695 | -0.014 | 1 | 0.534 |
PKCA |
0.695 | -0.039 | 2 | 0.624 |
RSK2 |
0.694 | -0.031 | -3 | 0.623 |
DCAMKL2 |
0.694 | -0.107 | -3 | 0.646 |
IRE2 |
0.693 | -0.103 | 2 | 0.665 |
CDK8 |
0.693 | -0.019 | 1 | 0.554 |
STK33 |
0.693 | -0.105 | 2 | 0.489 |
PKCH |
0.693 | -0.067 | 2 | 0.615 |
CDK6 |
0.693 | -0.035 | 1 | 0.542 |
CK2A1 |
0.692 | 0.064 | 1 | 0.678 |
MRCKA |
0.692 | -0.106 | -3 | 0.591 |
CDK14 |
0.692 | -0.039 | 1 | 0.568 |
NIM1 |
0.692 | -0.061 | 3 | 0.623 |
MELK |
0.691 | -0.088 | -3 | 0.642 |
GCN2 |
0.691 | -0.077 | 2 | 0.691 |
MAPKAPK3 |
0.691 | -0.047 | -3 | 0.617 |
AKT2 |
0.691 | -0.052 | -3 | 0.546 |
YANK3 |
0.690 | 0.008 | 2 | 0.312 |
PAK2 |
0.690 | -0.134 | -2 | 0.594 |
FAM20C |
0.690 | 0.068 | 2 | 0.495 |
CLK4 |
0.690 | -0.056 | -3 | 0.625 |
CDK4 |
0.690 | -0.046 | 1 | 0.521 |
SGK1 |
0.690 | -0.047 | -3 | 0.472 |
CAMK2A |
0.690 | -0.044 | 2 | 0.652 |
DYRK3 |
0.689 | -0.040 | 1 | 0.661 |
PLK4 |
0.689 | -0.077 | 2 | 0.506 |
SSTK |
0.688 | -0.065 | 4 | 0.632 |
P90RSK |
0.688 | -0.061 | -3 | 0.635 |
PAK3 |
0.688 | -0.104 | -2 | 0.615 |
PRKD1 |
0.688 | -0.009 | -3 | 0.682 |
DYRK1B |
0.688 | -0.053 | 1 | 0.588 |
BCKDK |
0.688 | -0.104 | -1 | 0.650 |
PKCG |
0.688 | -0.048 | 2 | 0.612 |
MNK2 |
0.687 | -0.029 | -2 | 0.650 |
ULK1 |
0.687 | -0.140 | -3 | 0.702 |
CDK18 |
0.686 | -0.012 | 1 | 0.529 |
CDK7 |
0.686 | -0.042 | 1 | 0.585 |
PKCI |
0.686 | -0.044 | 2 | 0.661 |
AURB |
0.686 | -0.056 | -2 | 0.489 |
DYRK4 |
0.686 | -0.030 | 1 | 0.559 |
PKACG |
0.685 | -0.071 | -2 | 0.575 |
NDR1 |
0.685 | -0.099 | -3 | 0.685 |
QIK |
0.685 | -0.128 | -3 | 0.686 |
MARK2 |
0.685 | -0.092 | 4 | 0.608 |
CDK9 |
0.685 | -0.046 | 1 | 0.570 |
CAMK4 |
0.685 | -0.145 | -3 | 0.668 |
MNK1 |
0.685 | -0.055 | -2 | 0.655 |
YANK2 |
0.685 | 0.011 | 2 | 0.324 |
CDK17 |
0.684 | -0.039 | 1 | 0.479 |
PRKD3 |
0.684 | -0.063 | -3 | 0.595 |
PKCE |
0.683 | -0.043 | 2 | 0.607 |
CHK2 |
0.683 | -0.074 | -3 | 0.485 |
CDK16 |
0.683 | -0.026 | 1 | 0.496 |
CAMK1G |
0.682 | -0.087 | -3 | 0.606 |
CAMK1D |
0.682 | -0.096 | -3 | 0.529 |
NUAK1 |
0.682 | -0.012 | -3 | 0.626 |
RSK3 |
0.682 | -0.054 | -3 | 0.625 |
CDK19 |
0.682 | -0.009 | 1 | 0.521 |
AURA |
0.681 | -0.056 | -2 | 0.470 |
QSK |
0.681 | -0.090 | 4 | 0.658 |
LATS2 |
0.680 | -0.055 | -5 | 0.685 |
AKT1 |
0.680 | -0.067 | -3 | 0.557 |
MAPKAPK2 |
0.680 | -0.019 | -3 | 0.571 |
PKG2 |
0.680 | -0.063 | -2 | 0.514 |
MSK1 |
0.680 | -0.067 | -3 | 0.610 |
CLK1 |
0.679 | -0.038 | -3 | 0.591 |
AURC |
0.679 | -0.019 | -2 | 0.490 |
KIS |
0.679 | 0.063 | 1 | 0.612 |
MARK3 |
0.678 | -0.092 | 4 | 0.622 |
RIPK2 |
0.678 | -0.246 | 1 | 0.627 |
BMPR2_TYR |
0.678 | 0.151 | -1 | 0.807 |
RSK4 |
0.678 | -0.057 | -3 | 0.600 |
PDHK3_TYR |
0.678 | 0.086 | 4 | 0.783 |
PKCT |
0.678 | -0.086 | 2 | 0.627 |
NDR2 |
0.677 | -0.056 | -3 | 0.706 |
PKACB |
0.677 | -0.038 | -2 | 0.516 |
PRKD2 |
0.677 | -0.040 | -3 | 0.610 |
CLK2 |
0.676 | -0.011 | -3 | 0.617 |
MARK1 |
0.676 | -0.132 | 4 | 0.637 |
MSK2 |
0.675 | -0.094 | -3 | 0.614 |
CK1G1 |
0.675 | 0.142 | -3 | 0.664 |
CDK10 |
0.675 | -0.037 | 1 | 0.557 |
TTBK1 |
0.672 | -0.138 | 2 | 0.543 |
MAP2K4_TYR |
0.672 | 0.028 | -1 | 0.709 |
CK1G3 |
0.671 | 0.114 | -3 | 0.533 |
SRPK2 |
0.671 | -0.028 | -3 | 0.545 |
MAP2K6_TYR |
0.671 | 0.053 | -1 | 0.726 |
P70S6K |
0.670 | -0.092 | -3 | 0.550 |
MAPKAPK5 |
0.670 | -0.099 | -3 | 0.574 |
PDHK1_TYR |
0.670 | 0.040 | -1 | 0.754 |
EPHA6 |
0.669 | 0.106 | -1 | 0.774 |
CAMK1A |
0.669 | -0.082 | -3 | 0.498 |
SIK |
0.668 | -0.108 | -3 | 0.604 |
PKMYT1_TYR |
0.668 | -0.017 | 3 | 0.711 |
SBK |
0.667 | -0.079 | -3 | 0.421 |
PDHK4_TYR |
0.666 | -0.006 | 2 | 0.703 |
CK1G2 |
0.665 | 0.132 | -3 | 0.605 |
PHKG1 |
0.664 | -0.111 | -3 | 0.680 |
HCK |
0.664 | 0.103 | -1 | 0.718 |
FYN |
0.664 | 0.142 | -1 | 0.750 |
SNRK |
0.664 | -0.185 | 2 | 0.566 |
ABL2 |
0.663 | 0.058 | -1 | 0.641 |
EPHB4 |
0.663 | 0.037 | -1 | 0.693 |
AKT3 |
0.663 | -0.056 | -3 | 0.490 |
TXK |
0.663 | 0.080 | 1 | 0.820 |
TESK1_TYR |
0.662 | -0.115 | 3 | 0.730 |
LCK |
0.662 | 0.117 | -1 | 0.742 |
MAP2K7_TYR |
0.662 | -0.161 | 2 | 0.701 |
BLK |
0.662 | 0.109 | -1 | 0.745 |
PTK2 |
0.661 | 0.169 | -1 | 0.823 |
PKACA |
0.661 | -0.065 | -2 | 0.461 |
FGR |
0.661 | 0.061 | 1 | 0.839 |
ABL1 |
0.660 | 0.065 | -1 | 0.628 |
PINK1_TYR |
0.660 | -0.116 | 1 | 0.769 |
PKN1 |
0.660 | -0.080 | -3 | 0.566 |
PAK6 |
0.659 | -0.063 | -2 | 0.526 |
BRSK1 |
0.659 | -0.117 | -3 | 0.642 |
SRMS |
0.658 | 0.021 | 1 | 0.828 |
YES1 |
0.657 | -0.000 | -1 | 0.673 |
EPHA4 |
0.657 | 0.015 | 2 | 0.605 |
SYK |
0.657 | 0.148 | -1 | 0.755 |
LIMK2_TYR |
0.657 | -0.072 | -3 | 0.747 |
CK1A |
0.656 | 0.142 | -3 | 0.572 |
FER |
0.656 | -0.014 | 1 | 0.840 |
EPHB2 |
0.656 | 0.035 | -1 | 0.686 |
PRKX |
0.656 | -0.037 | -3 | 0.536 |
ITK |
0.655 | 0.010 | -1 | 0.668 |
LIMK1_TYR |
0.653 | -0.155 | 2 | 0.724 |
EPHB1 |
0.653 | -0.005 | 1 | 0.812 |
BRSK2 |
0.652 | -0.167 | -3 | 0.658 |
TYK2 |
0.652 | -0.123 | 1 | 0.723 |
MST1R |
0.652 | -0.126 | 3 | 0.667 |
EPHB3 |
0.652 | 0.006 | -1 | 0.677 |
JAK2 |
0.652 | -0.095 | 1 | 0.711 |
TYRO3 |
0.652 | -0.101 | 3 | 0.644 |
ROS1 |
0.651 | -0.093 | 3 | 0.623 |
BMX |
0.650 | 0.004 | -1 | 0.608 |
TNK2 |
0.650 | -0.043 | 3 | 0.595 |
INSRR |
0.650 | -0.057 | 3 | 0.587 |
RET |
0.649 | -0.161 | 1 | 0.723 |
CSF1R |
0.649 | -0.101 | 3 | 0.645 |
PHKG2 |
0.649 | -0.119 | -3 | 0.639 |
MERTK |
0.649 | -0.018 | 3 | 0.618 |
SRC |
0.648 | 0.037 | -1 | 0.697 |
LYN |
0.648 | 0.029 | 3 | 0.586 |
EPHA7 |
0.647 | -0.007 | 2 | 0.621 |
MET |
0.646 | -0.049 | 3 | 0.625 |
DDR1 |
0.645 | -0.177 | 4 | 0.681 |
EPHA3 |
0.645 | -0.035 | 2 | 0.593 |
JAK3 |
0.644 | -0.099 | 1 | 0.689 |
EPHA8 |
0.644 | 0.011 | -1 | 0.724 |
FRK |
0.643 | -0.019 | -1 | 0.718 |
WEE1_TYR |
0.643 | -0.055 | -1 | 0.591 |
KIT |
0.643 | -0.109 | 3 | 0.639 |
PAK5 |
0.642 | -0.113 | -2 | 0.461 |
NTRK1 |
0.642 | -0.100 | -1 | 0.634 |
KDR |
0.642 | -0.094 | 3 | 0.601 |
FLT1 |
0.642 | -0.049 | -1 | 0.739 |
TNK1 |
0.642 | -0.077 | 3 | 0.643 |
TEC |
0.641 | -0.068 | -1 | 0.574 |
PTK6 |
0.641 | -0.120 | -1 | 0.535 |
BTK |
0.641 | -0.093 | -1 | 0.603 |
FLT3 |
0.640 | -0.124 | 3 | 0.642 |
EPHA5 |
0.640 | -0.022 | 2 | 0.587 |
PTK2B |
0.640 | -0.020 | -1 | 0.596 |
LTK |
0.640 | -0.084 | 3 | 0.595 |
PDGFRB |
0.640 | -0.172 | 3 | 0.641 |
INSR |
0.638 | -0.087 | 3 | 0.591 |
JAK1 |
0.638 | -0.094 | 1 | 0.648 |
MATK |
0.638 | -0.071 | -1 | 0.578 |
ERBB4 |
0.638 | 0.033 | 1 | 0.649 |
FGFR2 |
0.638 | -0.167 | 3 | 0.622 |
ERBB2 |
0.637 | -0.095 | 1 | 0.686 |
NTRK3 |
0.637 | -0.082 | -1 | 0.583 |
AXL |
0.637 | -0.128 | 3 | 0.600 |
EGFR |
0.636 | -0.037 | 1 | 0.603 |
TNNI3K_TYR |
0.636 | -0.074 | 1 | 0.752 |
EPHA1 |
0.636 | -0.078 | 3 | 0.611 |
PAK4 |
0.636 | -0.098 | -2 | 0.469 |
ALK |
0.635 | -0.131 | 3 | 0.559 |
EPHA2 |
0.635 | 0.001 | -1 | 0.708 |
CSK |
0.633 | -0.088 | 2 | 0.624 |
ZAP70 |
0.632 | 0.050 | -1 | 0.681 |
PKG1 |
0.631 | -0.105 | -2 | 0.440 |
FGFR4 |
0.630 | -0.084 | -1 | 0.611 |
NEK10_TYR |
0.630 | -0.175 | 1 | 0.567 |
FGFR3 |
0.630 | -0.147 | 3 | 0.598 |
IGF1R |
0.630 | -0.056 | 3 | 0.527 |
FGFR1 |
0.630 | -0.201 | 3 | 0.591 |
PDGFRA |
0.629 | -0.229 | 3 | 0.648 |
NTRK2 |
0.628 | -0.187 | 3 | 0.579 |
TEK |
0.628 | -0.203 | 3 | 0.577 |
DDR2 |
0.627 | -0.110 | 3 | 0.565 |
FLT4 |
0.627 | -0.168 | 3 | 0.613 |
FES |
0.621 | -0.058 | -1 | 0.567 |
MUSK |
0.621 | -0.091 | 1 | 0.607 |