Motif 1051 (n=216)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| B2RPK0 | HMGB1P1 | T22 | ochoa | High mobility group protein B1-like 1 (High mobility group protein 1-like 1) (HMG-1L1) | Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}. |
| O00443 | PIK3C2A | T614 | ochoa | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function. Involved in the regulation of ciliogenesis and trafficking of ciliary components (PubMed:31034465). {ECO:0000269|PubMed:10766823, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11239472, ECO:0000269|PubMed:12719431, ECO:0000269|PubMed:16215232, ECO:0000269|PubMed:21081650, ECO:0000269|PubMed:31034465, ECO:0000269|PubMed:9337861}. |
| O14641 | DVL2 | T206 | psp | Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) | Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}. |
| O14745 | NHERF1 | T156 | psp | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}. |
| O14939 | PLD2 | T175 | psp | Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) | Function as phospholipase selective for phosphatidylcholine (PubMed:9582313). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity). {ECO:0000250|UniProtKB:P97813, ECO:0000269|PubMed:9582313}. |
| O14974 | PPP1R12A | T765 | ochoa | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}. |
| O14976 | GAK | T794 | ochoa | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269|PubMed:10625686, ECO:0000269|PubMed:18489706}. |
| O15085 | ARHGEF11 | T585 | ochoa | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}. |
| O15143 | ARPC1B | T21 | psp | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}. |
| O43293 | DAPK3 | T225 | psp | Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) | Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. {ECO:0000269|PubMed:10356987, ECO:0000269|PubMed:11384979, ECO:0000269|PubMed:11781833, ECO:0000269|PubMed:12917339, ECO:0000269|PubMed:15096528, ECO:0000269|PubMed:15367680, ECO:0000269|PubMed:16219639, ECO:0000269|PubMed:17126281, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:18995835, ECO:0000269|PubMed:21169990, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:21487036, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:38009294}. |
| O43688 | PLPP2 | T270 | ochoa | Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) | Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:16467304, PubMed:9607309, PubMed:9705349). Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly (PubMed:16467304). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (Probable). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity). {ECO:0000250|UniProtKB:Q8K593, ECO:0000269|PubMed:16467304, ECO:0000269|PubMed:9607309, ECO:0000269|PubMed:9705349, ECO:0000305|PubMed:16467304}. |
| O43930 | PRKY | T201 | ochoa | Putative serine/threonine-protein kinase PRKY (EC 2.7.11.1) | None |
| O60583 | CCNT2 | T597 | ochoa | Cyclin-T2 (CycT2) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:15563843, PubMed:9499409). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.; FUNCTION: (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters. {ECO:0000269|PubMed:21509660}. |
| O75069 | TMCC2 | T466 | ochoa | Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11) | May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. {ECO:0000269|PubMed:21593558}. |
| O75152 | ZC3H11A | T731 | ochoa | Zinc finger CCCH domain-containing protein 11A | Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed:22928037, PubMed:37356722). Binds RNA (PubMed:29610341, PubMed:37356722). {ECO:0000269|PubMed:22928037, ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}.; FUNCTION: (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed:29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed:37356722). {ECO:0000269|PubMed:29610341, ECO:0000269|PubMed:37356722}. |
| O75962 | TRIO | T2513 | ochoa | Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1, ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539, ECO:0000269|PubMed:32109419, ECO:0000269|PubMed:8643598}. |
| O94885 | SASH1 | T405 | ochoa | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. |
| O95977 | S1PR4 | T351 | ochoa | Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. {ECO:0000269|PubMed:10679247, ECO:0000269|PubMed:10753843}. |
| P00533 | EGFR | T430 | psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P09086 | POU2F2 | T270 | ochoa | POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2) | Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874). {ECO:0000250|UniProtKB:Q00196, ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:7859290}.; FUNCTION: [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980}. |
| P11388 | TOP2A | T1406 | ochoa | DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}. |
| P14923 | JUP | T19 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P14923 | JUP | T21 | ochoa | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}. |
| P15822 | HIVEP1 | T534 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P20929 | NEB | T1867 | ochoa | Nebulin | This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
| P22314 | UBA1 | T603 | ochoa | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). {ECO:0000269|PubMed:1447181, ECO:0000269|PubMed:1606621, ECO:0000269|PubMed:22456334, ECO:0000269|PubMed:33108101}. |
| P23471 | PTPRZ1 | T2054 | ochoa | Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) | Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). {ECO:0000250}. |
| P25445 | FAS | T305 | ochoa | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181, ECO:0000269|PubMed:9184224}. |
| P27448 | MARK3 | T438 | ochoa | MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) | Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. |
| P28290 | ITPRID2 | T828 | ochoa | Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2) | None |
| P30414 | NKTR | T193 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30414 | NKTR | T472 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30414 | NKTR | T512 | ochoa | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:8421688}. |
| P30556 | AGTR1 | T332 | psp | Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor) | Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768, PubMed:8987975). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106). {ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:1567413, ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0000269|PubMed:8987975}.; FUNCTION: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. {ECO:0000269|PubMed:33713620}. |
| P35251 | RFC1 | T1073 | ochoa | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35348 | ADRA1A | T411 | psp | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}. |
| P35968 | KDR | Y951 | ochoa|psp | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}. |
| P37198 | NUP62 | T269 | psp | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}. |
| P38432 | COIL | T303 | ochoa | Coilin (p80-coilin) | Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}. |
| P42331 | ARHGAP25 | T442 | ochoa | Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| P42695 | NCAPD3 | T1379 | ochoa | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269|PubMed:14532007, ECO:0000269|PubMed:27737959}. |
| P43630 | KIR3DL2 | T429 | ochoa | Killer cell immunoglobulin-like receptor 3DL2 (CD158 antigen-like family member K) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor clone CL-5) (p70 NK receptor CL-5) (CD antigen CD158k) | Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270). Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464). {ECO:0000269|PubMed:24018270, ECO:0000269|PubMed:26928464, ECO:0000269|PubMed:28636952}. |
| P46013 | MKI67 | T858 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2460 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2502 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46087 | NOP2 | T663 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P46100 | ATRX | T810 | ochoa | Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) | Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}. |
| P46736 | BRCC3 | T260 | ochoa | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) (PubMed:14636569, PubMed:16707425, PubMed:17525341, PubMed:19202061, PubMed:19261746, PubMed:19261748, PubMed:19261749). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26195665, PubMed:26344097). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity). {ECO:0000250|UniProtKB:P46737, ECO:0000269|PubMed:14636569, ECO:0000269|PubMed:16707425, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26344097}. |
| P46821 | MAP1B | T1680 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49639 | HOXA1 | T299 | ochoa | Homeobox protein Hox-A1 (Homeobox protein Hox-1F) | Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). {ECO:0000250|UniProtKB:P09022, ECO:0000250|UniProtKB:Q90423, ECO:0000269|PubMed:16155570}. |
| P49916 | LIG3 | T849 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P50851 | LRBA | T1579 | ochoa | Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein) | Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250|UniProtKB:Q9ESE1, ECO:0000269|PubMed:33773106}. |
| P51587 | BRCA2 | T363 | ochoa | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}. |
| P51817 | PRKX | T201 | ochoa | cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1) | Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:12082174, ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:17980165, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272, ECO:0000269|PubMed:9860982}. |
| P51825 | AFF1 | T220 | ochoa|psp | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P51825 | AFF1 | T379 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P51957 | NEK4 | T667 | ochoa | Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| P54296 | MYOM2 | T676 | ochoa | Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P54646 | PRKAA2 | T506 | ochoa | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) | Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). Involved in insulin receptor/INSR internalization (PubMed:25687571). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11518699, PubMed:11554766, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process, it also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (PubMed:36017701). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (PubMed:28552616). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (PubMed:36367943). {ECO:0000250|UniProtKB:Q09137, ECO:0000250|UniProtKB:Q8BRK8, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36017701, ECO:0000269|PubMed:36367943, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:7959015, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}. |
| P55199 | ELL | T180 | ochoa | RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) | Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. {ECO:0000269|PubMed:16006523, ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:22252557, ECO:0000269|PubMed:23932780, ECO:0000269|PubMed:8596958}. |
| P58753 | TIRAP | T28 | psp | Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2) | Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6). {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286, ECO:0000269|PubMed:21829704}. |
| P82094 | TMF1 | T255 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| P98196 | ATP11A | T733 | ochoa | Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401, PubMed:36300302). Does not show flippase activity toward phosphatidylcholine (PC) (PubMed:34403372). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. {ECO:0000269|PubMed:15860663, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:26567335, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:30018401, ECO:0000269|PubMed:34403372, ECO:0000269|PubMed:36300302, ECO:0000305}. |
| P98198 | ATP8B2 | T1178 | ochoa | Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2) | Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry. {ECO:0000269|PubMed:25315773}. |
| Q02641 | CACNB1 | T45 | ochoa | Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1) | Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}. |
| Q02952 | AKAP12 | T1115 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | T2172 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q05469 | LIPE | T813 | ochoa | Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH) | Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:15716583, PubMed:15955102, PubMed:19800417, PubMed:8812477). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and preferentially hydrolyzes the fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs (PubMed:19800417). Preferentially hydrolyzes FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity). {ECO:0000250|UniProtKB:P15304, ECO:0000250|UniProtKB:P54310, ECO:0000269|PubMed:15716583, ECO:0000269|PubMed:15955102, ECO:0000269|PubMed:19800417, ECO:0000269|PubMed:8812477}. |
| Q12830 | BPTF | T739 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12830 | BPTF | T2241 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12879 | GRIN2A | T888 | ochoa | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:20890276, PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:28242877, PubMed:36117210, PubMed:38538865, PubMed:8768735). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:23933818, PubMed:23933819, PubMed:23933820, PubMed:24504326, PubMed:26875626, PubMed:26919761, PubMed:27288002, PubMed:28095420, PubMed:28105280, PubMed:28126851, PubMed:28182669, PubMed:29644724, PubMed:38307912, PubMed:8768735). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626, PubMed:26919761). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:20890276, ECO:0000269|PubMed:23933818, ECO:0000269|PubMed:23933819, ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:24504326, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27288002, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:28182669, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:29644724, ECO:0000269|PubMed:36117210, ECO:0000269|PubMed:38307912, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}. |
| Q14004 | CDK13 | T1056 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14814 | MEF2D | T286 | ochoa | Myocyte-specific enhancer factor 2D | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}. |
| Q15276 | RABEP1 | T413 | ochoa | Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}. |
| Q15648 | MED1 | T796 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15650 | TRIP4 | T275 | ochoa | Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (PubMed:10454579, PubMed:25219498). May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 (PubMed:12077347). Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). {ECO:0000250|UniProtKB:Q9QXN3, ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26924529, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| Q15714 | TSC22D1 | T264 | ochoa | TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}. |
| Q15714 | TSC22D1 | T265 | ochoa | TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}. |
| Q15717 | ELAVL1 | T118 | psp | ELAV-like protein 1 (Hu-antigen R) (HuR) | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:17632515, ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23519412, ECO:0000269|PubMed:29180010, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8626503}. |
| Q15762 | CD226 | T288 | ochoa | CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226) | Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:9712030). Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:26755705, PubMed:31253644, PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity). {ECO:0000250|UniProtKB:Q8K4F0, ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:30591568, ECO:0000269|PubMed:31253644, ECO:0000269|PubMed:8673704, ECO:0000269|PubMed:9712030}. |
| Q15831 | STK11 | T402 | psp | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:11430832, ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379, ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.; FUNCTION: [Isoform 2]: Has a role in spermiogenesis. {ECO:0000250}. |
| Q1W6H9 | FAM110C | T238 | ochoa | Protein FAM110C | May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway. {ECO:0000269|PubMed:17499476, ECO:0000269|PubMed:19698782}. |
| Q2LD37 | BLTP1 | T1325 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q2LD37 | BLTP1 | T2605 | ochoa | Bridge-like lipid transfer protein family member 1 (Fragile site-associated protein) | Tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum (Probable). Plays a role in endosomal trafficking and endosome recycling. Also involved in the actin cytoskeleton and cilia structural dynamics (PubMed:30906834). Acts as a regulator of phagocytosis (PubMed:31540829). {ECO:0000269|PubMed:30906834, ECO:0000269|PubMed:31540829, ECO:0000305|PubMed:35015055, ECO:0000305|PubMed:35491307}. |
| Q3L8U1 | CHD9 | T2868 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q4KWH8 | PLCH1 | T1066 | ochoa | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3) | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}. |
| Q4W5G0 | TIGD2 | T445 | ochoa | Tigger transposable element-derived protein 2 | None |
| Q4ZHG4 | FNDC1 | T538 | ochoa | Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) | May be an activator of G protein signaling. {ECO:0000250}. |
| Q56NI9 | ESCO2 | T62 | ochoa | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}. |
| Q58EX2 | SDK2 | T2103 | ochoa | Protein sidekick-2 | Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions. {ECO:0000250|UniProtKB:Q6V4S5}. |
| Q5JTC6 | AMER1 | T326 | psp | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. {ECO:0000269|PubMed:17510365, ECO:0000269|PubMed:17925383, ECO:0000269|PubMed:19416806, ECO:0000269|PubMed:21304492, ECO:0000269|PubMed:21498506}. |
| Q5M775 | SPECC1 | T335 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5QJE6 | DNTTIP2 | T433 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5TC84 | OGFRL1 | T340 | ochoa | Opioid growth factor receptor-like protein 1 | None |
| Q5VST9 | OBSCN | T2441 | ochoa | Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) (PubMed:28826662). {ECO:0000250|UniProtKB:A2AAJ9, ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939, ECO:0000269|PubMed:28826662}. |
| Q5VT52 | RPRD2 | T734 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VZK9 | CARMIL1 | T1228 | ochoa | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). {ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}. |
| Q68CJ9 | CREB3L3 | T429 | psp | Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations (PubMed:21666694). {ECO:0000250, ECO:0000250|UniProtKB:Q91XE9, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704, ECO:0000269|PubMed:21666694}. |
| Q68DC2 | ANKS6 | T736 | ochoa | Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) | Required for renal function. {ECO:0000269|PubMed:23793029}. |
| Q6AHZ1 | ZNF518A | T532 | ochoa | Zinc finger protein 518A | Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. {ECO:0000250|UniProtKB:B2RRF6}. |
| Q6AWC2 | WWC2 | T530 | ochoa | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. {ECO:0000269|PubMed:24682284}. |
| Q6AWC2 | WWC2 | T533 | ochoa | Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. {ECO:0000269|PubMed:24682284}. |
| Q6N043 | ZNF280D | T804 | ochoa | Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634) | May function as a transcription factor. |
| Q6NXE6 | ARMC6 | T88 | ochoa | Armadillo repeat-containing protein 6 | None |
| Q6NXT6 | TAPT1 | T473 | ochoa | Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) | Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). {ECO:0000250|UniProtKB:A2BIE7, ECO:0000250|UniProtKB:Q4VBD2, ECO:0000269|PubMed:26365339}.; FUNCTION: (Microbial infection) In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169. {ECO:0000269|PubMed:10640539}. |
| Q6P3W7 | SCYL2 | T712 | ochoa | SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) | Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). {ECO:0000250|UniProtKB:Q8CFE4, ECO:0000269|PubMed:15809293, ECO:0000269|PubMed:16914521, ECO:0000305|PubMed:15809293, ECO:0000305|PubMed:16914521}. |
| Q6UB99 | ANKRD11 | T829 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6VMQ6 | ATF7IP | T928 | ochoa | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (PubMed:27732843). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 (PubMed:12665582). Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086, PubMed:27732843). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (PubMed:19106100). {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100, ECO:0000269|PubMed:27732843}. |
| Q6ZU80 | CEP128 | T128 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q6ZU80 | CEP128 | T1035 | ochoa | Centrosomal protein of 128 kDa (Cep128) | None |
| Q70E73 | RAPH1 | T190 | ochoa | Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Q70EL1 | USP54 | T1422 | ochoa | Ubiquitin carboxyl-terminal hydrolase 54 (EC 3.4.19.12) (Ubiquitin-specific peptidase 54) | Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171). {ECO:0000269|PubMed:36590171, ECO:0000269|PubMed:39587316}. |
| Q71F56 | MED13L | T779 | ochoa | Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Q765P7 | MTSS2 | T336 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q76N89 | HECW1 | T67 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Q7Z407 | CSMD3 | T2679 | ochoa | CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) | Involved in dendrite development. {ECO:0000250|UniProtKB:Q80T79}. |
| Q7Z6E9 | RBBP6 | T1222 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6E9 | RBBP6 | T1468 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q86VQ1 | GLCCI1 | T266 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q8IVM0 | CCDC50 | T280 | ochoa | Coiled-coil domain-containing protein 50 (Protein Ymer) | Involved in EGFR signaling. {ECO:0000269|PubMed:15314609}. |
| Q8IW50 | FAM219A | T113 | ochoa | Protein FAM219A | None |
| Q8IWU2 | LMTK2 | T789 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IX03 | WWC1 | T251 | ochoa | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway (PubMed:24682284). Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway (PubMed:24682284). Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway (PubMed:20159598). Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation (PubMed:16684779). Regulates collagen-stimulated activation of the ERK/MAPK cascade (PubMed:18190796). Modulates directional migration of podocytes (PubMed:18596123). Plays a role in cognition and memory performance (PubMed:18672031). Plays an important role in regulating AMPA-selective glutamate receptors (AMPARs) trafficking underlying synaptic plasticity and learning (By similarity). {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}. |
| Q8N1W1 | ARHGEF28 | T772 | ochoa | Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor) | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). {ECO:0000250}. |
| Q8N264 | ARHGAP24 | T624 | ochoa | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Q8N3S3 | PHTF2 | T223 | ochoa | Protein PHTF2 | None |
| Q8N4C8 | MINK1 | T809 | ochoa | Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:10708748, PubMed:16337592). Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (By similarity). Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (PubMed:18930710, PubMed:21690388). Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000250|UniProtKB:F1LP90, ECO:0000250|UniProtKB:Q9JM52, ECO:0000269|PubMed:10708748, ECO:0000269|PubMed:16337592, ECO:0000269|PubMed:18930710, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
| Q8N6T3 | ARFGAP1 | T189 | ochoa | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Q8NAN2 | MIGA1 | T142 | ochoa | Mitoguardin 1 (Protein FAM73A) | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. {ECO:0000269|PubMed:26711011}. |
| Q8NCE2 | MTMR14 | T424 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8ND82 | ZNF280C | T543 | ochoa | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | May function as a transcription factor. |
| Q8NDI1 | EHBP1 | T785 | ochoa | EH domain-binding protein 1 | May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}. |
| Q8NDL9 | AGBL5 | T587 | ochoa | Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein-like 5) (Protein deglutamylase CCP5) | Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation. {ECO:0000250|UniProtKB:Q09M02}. |
| Q8NEZ4 | KMT2C | T1219 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NG31 | KNL1 | T586 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TBA6 | GOLGA5 | T43 | ochoa | Golgin subfamily A member 5 (Cell proliferation-inducing gene 31 protein) (Golgin-84) (Protein Ret-II) (RET-fused gene 5 protein) | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}. |
| Q8TDN4 | CABLES1 | T415 | ochoa|psp | CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) | Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}. |
| Q8TEV9 | SMCR8 | T666 | psp | Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein) | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27103069, PubMed:27193190, PubMed:27559131, PubMed:27617292, PubMed:28195531, PubMed:32303654). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (PubMed:32303654). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531). {ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:27193190, ECO:0000269|PubMed:27559131, ECO:0000269|PubMed:27617292, ECO:0000269|PubMed:28195531, ECO:0000269|PubMed:32303654}. |
| Q8WUY3 | PRUNE2 | T1618 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WYP5 | AHCTF1 | T1175 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92547 | TOPBP1 | T298 | ochoa | DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1) | Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair (PubMed:10498869, PubMed:11395493, PubMed:11714696, PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:33592542, PubMed:35597237, PubMed:37674080). Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:17575048, PubMed:20545769, PubMed:21777809, PubMed:26811421, PubMed:30898438, PubMed:31135337, PubMed:35597237, PubMed:37674080). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (PubMed:30898438, PubMed:35597237, PubMed:37674080). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (PubMed:26811421, PubMed:35597237). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (PubMed:37674080). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (PubMed:37674080). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (PubMed:37674080). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (PubMed:31135337). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (PubMed:16530042, PubMed:21777809). Acts as an activator of the kinase activity of ATR (PubMed:16530042, PubMed:21777809). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (PubMed:12697828, PubMed:15075294). {ECO:0000250|UniProtKB:Q800K6, ECO:0000269|PubMed:10498869, ECO:0000269|PubMed:11395493, ECO:0000269|PubMed:11714696, ECO:0000269|PubMed:12697828, ECO:0000269|PubMed:15075294, ECO:0000269|PubMed:16530042, ECO:0000269|PubMed:17575048, ECO:0000269|PubMed:20545769, ECO:0000269|PubMed:21777809, ECO:0000269|PubMed:26811421, ECO:0000269|PubMed:30898438, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:33592542, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35597237, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668, ECO:0000269|PubMed:37674080}. |
| Q92610 | ZNF592 | T1049 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q92922 | SMARCC1 | T417 | ochoa | SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q96GQ7 | DDX27 | T346 | ochoa | Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27) | Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154). {ECO:0000269|PubMed:25825154}. |
| Q96HN2 | AHCYL2 | T163 | ochoa | Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.13.2.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) | May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705). {ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}. |
| Q96JE7 | SEC16B | T171 | ochoa | Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B) | Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:21768384, PubMed:22355596). Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes (PubMed:21768384). {ECO:0000269|PubMed:17192411, ECO:0000269|PubMed:21768384, ECO:0000303|PubMed:22355596}. |
| Q96QT4 | TRPM7 | T1583 | psp | Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form] | Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250|UniProtKB:Q923J1, ECO:0000269|PubMed:11385574, ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:18365021, ECO:0000269|PubMed:18394644, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741, ECO:0000269|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250|UniProtKB:Q923J1}. |
| Q96RU2 | USP28 | T710 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q9BZE9 | ASPSCR1 | T167 | ochoa | Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9) | Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT. {ECO:0000250, ECO:0000269|PubMed:23349634}. |
| Q9BZF1 | OSBPL8 | T819 | ochoa | Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935). Binds oxysterol, 25-hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:17991739, ECO:0000269|PubMed:21698267, ECO:0000269|PubMed:26206935}. |
| Q9C0B5 | ZDHHC5 | T452 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9C0C9 | UBE2O | T491 | ochoa | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:23455153, ECO:0000269|PubMed:24703950}. |
| Q9C0D5 | TANC1 | T180 | ochoa | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | May be a scaffold component in the postsynaptic density. {ECO:0000250}. |
| Q9GZZ9 | UBA5 | T373 | ochoa | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:20368332, PubMed:25219498, PubMed:26929408, PubMed:27545674, PubMed:27545681, PubMed:27653677, PubMed:30412706, PubMed:30626644, PubMed:34588452). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:26929408, PubMed:27653677, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677, PubMed:34588452). Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:30412706, PubMed:32160526, PubMed:35394863). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity). {ECO:0000250|UniProtKB:Q8VE47, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:20368332, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27545674, ECO:0000269|PubMed:27545681, ECO:0000269|PubMed:27653677, ECO:0000269|PubMed:29295865, ECO:0000269|PubMed:30412706, ECO:0000269|PubMed:30626644, ECO:0000269|PubMed:32160526, ECO:0000269|PubMed:34588452, ECO:0000269|PubMed:35394863}. |
| Q9H9S0 | NANOG | T200 | psp | Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000269|PubMed:15983365, ECO:0000269|PubMed:16000880, ECO:0000269|PubMed:16391521, ECO:0000269|PubMed:25825768}. |
| Q9HA47 | UCK1 | T251 | ochoa | Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}. |
| Q9HCL0 | PCDH18 | T784 | ochoa | Protocadherin-18 | Potential calcium-dependent cell-adhesion protein. |
| Q9NP62 | GCM1 | T174 | psp | Chorion-specific transcription factor GCMa (hGCMa) (GCM motif protein 1) (Glial cells missing homolog 1) | Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). {ECO:0000269|PubMed:10542267, ECO:0000269|PubMed:18160678, ECO:0000269|PubMed:19219068, ECO:0000269|PubMed:27917469}. |
| Q9NQ75 | CASS4 | T388 | ochoa | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}. |
| Q9NQ88 | TIGAR | T164 | ochoa | Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase) | Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:22887998, PubMed:23726973, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:16839880, ECO:0000269|PubMed:19015259, ECO:0000269|PubMed:19713938, ECO:0000269|PubMed:22887998, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:23726973, ECO:0000269|PubMed:23817040, ECO:0000269|PubMed:25928429}. |
| Q9NQW6 | ANLN | T75 | ochoa | Anillin | Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269|PubMed:10931866, ECO:0000269|PubMed:12479805, ECO:0000269|PubMed:15496454, ECO:0000269|PubMed:16040610, ECO:0000269|PubMed:16357138, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:24676636}. |
| Q9NUQ6 | SPATS2L | T393 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NW68 | BSDC1 | T107 | ochoa | BSD domain-containing protein 1 | None |
| Q9NYB9 | ABI2 | T240 | ochoa | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Q9P0M6 | MACROH2A2 | T170 | ochoa | Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2) | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. {ECO:0000269|PubMed:15621527}. |
| Q9P1W3 | TMEM63C | T79 | ochoa | Osmosensitive cation channel TMEM63C (Calcium permeable stress-gated cation channel 1) (Transmembrane protein 63C) (hTMEM63C) | Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (PubMed:24503647, PubMed:35718349). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (PubMed:35718349). In particular may regulate mitochondrial motility and function in motor neuron axons (PubMed:35718349). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). {ECO:0000250|UniProtKB:D3ZNF5, ECO:0000269|PubMed:24503647, ECO:0000269|PubMed:35718349, ECO:0000269|PubMed:39716028}. |
| Q9P1Y6 | PHRF1 | T981 | ochoa | PHD and RING finger domain-containing protein 1 | None |
| Q9P242 | NYAP2 | T506 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P265 | DIP2B | T211 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9P2F8 | SIPA1L2 | T1486 | ochoa | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | None |
| Q9UBL0 | ARPP21 | T381 | ochoa | cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein) | Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. {ECO:0000250}. |
| Q9UHB6 | LIMA1 | T265 | ochoa | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) | Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. |
| Q9UHB7 | AFF4 | T359 | ochoa | AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) | Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Q9UKV3 | ACIN1 | T563 | ochoa | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
| Q9ULD2 | MTUS1 | T797 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULD2 | MTUS1 | T800 | ochoa | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. |
| Q9ULH0 | KIDINS220 | T1743 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULS5 | TMCC3 | T244 | ochoa | Transmembrane and coiled-coil domain protein 3 | None |
| Q9UMD9 | COL17A1 | T182 | ochoa | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; FUNCTION: The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. |
| Q9UNF0 | PACSIN2 | T391 | ochoa | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}. |
| Q9UPA5 | BSN | T1312 | ochoa | Protein bassoon (Zinc finger protein 231) | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12812759). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (PubMed:19380881). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000269|PubMed:12812759, ECO:0000269|PubMed:19380881}. |
| Q9UPM8 | AP4E1 | T859 | ochoa | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) | Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable). {ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000305|PubMed:10066790, ECO:0000305|PubMed:10436028}. |
| Q9UPQ9 | TNRC6B | T565 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPU5 | USP24 | T2565 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPW0 | FOXJ3 | T65 | ochoa | Forkhead box protein J3 | Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q8BUR3}. |
| Q9UQ35 | SRRM2 | T251 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9Y286 | SIGLEC7 | T411 | ochoa | Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328) | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}. |
| Q9Y2D8 | SSX2IP | T534 | ochoa | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). {ECO:0000250|UniProtKB:Q8VC66, ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449, ECO:0000305|PubMed:26545777}. |
| Q9Y2F5 | ICE1 | T455 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y2L6 | FRMD4B | T585 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y3M8 | STARD13 | T180 | ochoa | StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13) | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. {ECO:0000269|PubMed:14697242, ECO:0000269|PubMed:16217026}. |
| Q9Y426 | C2CD2 | T521 | ochoa | C2 domain-containing protein 2 (Transmembrane protein 24-like) | None |
| Q9Y483 | MTF2 | T451 | ochoa | Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250|UniProtKB:Q02395, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:31959557}. |
| Q9Y4B4 | RAD54L2 | T1029 | ochoa | Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) | DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity). {ECO:0000250}. |
| Q9Y4F3 | MARF1 | T714 | ochoa | Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1) | Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}. |
| Q9Y6D5 | ARFGEF2 | T243 | ochoa | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2) | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. {ECO:0000269|PubMed:12051703, ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15385626, ECO:0000269|PubMed:16477018, ECO:0000269|PubMed:17276987, ECO:0000269|PubMed:18625701, ECO:0000269|PubMed:20360857}. |
| P62917 | RPL8 | T135 | Sugiyama | Large ribosomal subunit protein uL2 (60S ribosomal protein L8) | Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000305|PubMed:12962325}. |
| P42167 | TMPO | T160 | Sugiyama | Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)] | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. |
| O43283 | MAP3K13 | T288 | Sugiyama | Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) | Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}. |
| P11766 | ADH5 | T127 | Sugiyama | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Class-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (PubMed:33355142). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity). {ECO:0000250|UniProtKB:P28474, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:33355142, ECO:0000269|PubMed:8460164}. |
| P35268 | RPL22 | T62 | Sugiyama | Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) | Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}. |
| P31327 | CPS1 | T771 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| Q15650 | TRIP4 | T280 | Sugiyama | Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (PubMed:10454579, PubMed:25219498). May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 (PubMed:12077347). Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). {ECO:0000250|UniProtKB:Q9QXN3, ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:25219498, ECO:0000269|PubMed:26924529, ECO:0000269|PubMed:32099016, ECO:0000269|PubMed:32579943, ECO:0000269|PubMed:36302773}. |
| O60941 | DTNB | T69 | EPSD|PSP | Dystrobrevin beta (DTN-B) (Beta-dystrobrevin) | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity). {ECO:0000250|UniProtKB:O70585, ECO:0000269|PubMed:27223470}. |
| P06213 | INSR | T1362 | SIGNOR|EPSD | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}. |
| P31939 | ATIC | T143 | Sugiyama | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10985775, ECO:0000269|PubMed:11948179, ECO:0000269|PubMed:14756554, ECO:0000269|PubMed:25687571, ECO:0000269|PubMed:9378707}. |
| P12270 | TPR | T2214 | SIGNOR | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| O60563 | CCNT1 | T580 | Sugiyama | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| Q9H2D6 | TRIOBP | T447 | SIGNOR | TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin) | [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}. |
| Q9UBK2 | PPARGC1A | T178 | SIGNOR | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250|UniProtKB:O70343, ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:28363985, ECO:0000269|PubMed:32433991}. |
| P35568 | IRS1 | T88 | SIGNOR | Insulin receptor substrate 1 (IRS-1) | Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250|UniProtKB:P35570, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16878150, ECO:0000269|PubMed:19639489, ECO:0000269|PubMed:38625937, ECO:0000269|PubMed:7541045, ECO:0000269|PubMed:8265614}. |
| Q16512 | PKN1 | T63 | Sugiyama | Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
| Q9Y5B9 | SUPT16H | T494 | EPSD|PSP | FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}. |
| Q15417 | CNN3 | T224 | Sugiyama | Calponin-3 (Calponin, acidic isoform) | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Q99700 | ATXN2 | T811 | Sugiyama | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q9H814 | PHAX | T49 | Sugiyama | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus (PubMed:39011894). Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA. {ECO:0000250, ECO:0000269|PubMed:15574332, ECO:0000269|PubMed:15574333}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.000092 | 4.037 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.001671 | 2.777 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.001671 | 2.777 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.002025 | 2.694 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.002174 | 2.663 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.001802 | 2.744 |
| R-HSA-74713 | IRS activation | 0.004858 | 2.314 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.005271 | 2.278 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.004891 | 2.311 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.007476 | 2.126 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.007467 | 2.127 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.007878 | 2.104 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.009634 | 2.016 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.010020 | 1.999 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.009057 | 2.043 |
| R-HSA-5467343 | Deletions in the AMER1 gene destabilize the destruction complex | 0.014488 | 1.839 |
| R-HSA-9673013 | Diseases of Telomere Maintenance | 0.028767 | 1.541 |
| R-HSA-9670621 | Defective Inhibition of DNA Recombination at Telomere | 0.028767 | 1.541 |
| R-HSA-9006821 | Alternative Lengthening of Telomeres (ALT) | 0.028767 | 1.541 |
| R-HSA-9670615 | Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations | 0.028767 | 1.541 |
| R-HSA-9763198 | Impaired BRCA2 binding to SEM1 (DSS1) | 0.028767 | 1.541 |
| R-HSA-9670613 | Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations | 0.028767 | 1.541 |
| R-HSA-9709275 | Impaired BRCA2 translocation to the nucleus | 0.028767 | 1.541 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.042840 | 1.368 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.070380 | 1.153 |
| R-HSA-5368598 | Negative regulation of TCF-dependent signaling by DVL-interacting proteins | 0.070380 | 1.153 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 0.083852 | 1.076 |
| R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation | 0.015823 | 1.801 |
| R-HSA-9673768 | Signaling by membrane-tethered fusions of PDGFRA or PDGFRB | 0.097130 | 1.013 |
| R-HSA-4839748 | Signaling by AMER1 mutants | 0.020670 | 1.685 |
| R-HSA-9833576 | CDH11 homotypic and heterotypic interactions | 0.110217 | 0.958 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 0.110217 | 0.958 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 0.110217 | 0.958 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 0.123114 | 0.910 |
| R-HSA-112412 | SOS-mediated signalling | 0.135826 | 0.867 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.012919 | 1.889 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.012919 | 1.889 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 0.148354 | 0.829 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.148354 | 0.829 |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | 0.160701 | 0.794 |
| R-HSA-170984 | ARMS-mediated activation | 0.160701 | 0.794 |
| R-HSA-201688 | WNT mediated activation of DVL | 0.160701 | 0.794 |
| R-HSA-5218900 | CASP8 activity is inhibited | 0.160701 | 0.794 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.059822 | 1.223 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.184863 | 0.733 |
| R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex | 0.184863 | 0.733 |
| R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex | 0.184863 | 0.733 |
| R-HSA-5467337 | APC truncation mutants have impaired AXIN binding | 0.184863 | 0.733 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.184863 | 0.733 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.196683 | 0.706 |
| R-HSA-5339716 | Signaling by GSK3beta mutants | 0.196683 | 0.706 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.030525 | 1.515 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.032221 | 1.492 |
| R-HSA-4839743 | Signaling by CTNNB1 phospho-site mutants | 0.208332 | 0.681 |
| R-HSA-5358749 | CTNNB1 S37 mutants aren't phosphorylated | 0.208332 | 0.681 |
| R-HSA-5358751 | CTNNB1 S45 mutants aren't phosphorylated | 0.208332 | 0.681 |
| R-HSA-5358752 | CTNNB1 T41 mutants aren't phosphorylated | 0.208332 | 0.681 |
| R-HSA-5358747 | CTNNB1 S33 mutants aren't phosphorylated | 0.208332 | 0.681 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 0.219813 | 0.658 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 0.093325 | 1.030 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.093325 | 1.030 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.097827 | 1.010 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.231128 | 0.636 |
| R-HSA-9933937 | Formation of the canonical BAF (cBAF) complex | 0.231128 | 0.636 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 0.231128 | 0.636 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.102389 | 0.990 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.102389 | 0.990 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.242280 | 0.616 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.242280 | 0.616 |
| R-HSA-196299 | Beta-catenin phosphorylation cascade | 0.242280 | 0.616 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 0.242280 | 0.616 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 0.242280 | 0.616 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.111682 | 0.952 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.111682 | 0.952 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.116409 | 0.934 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.253271 | 0.596 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.121185 | 0.917 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.126009 | 0.900 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.264103 | 0.578 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.264103 | 0.578 |
| R-HSA-4641258 | Degradation of DVL | 0.135789 | 0.867 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.145732 | 0.836 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.285299 | 0.545 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.150759 | 0.822 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.295669 | 0.529 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.305888 | 0.514 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.305888 | 0.514 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.305888 | 0.514 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.305888 | 0.514 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.305888 | 0.514 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.305888 | 0.514 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.315960 | 0.500 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.069142 | 1.160 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.116207 | 0.935 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.325886 | 0.487 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.345311 | 0.462 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.145541 | 0.837 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.239926 | 0.620 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.180603 | 0.743 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.184229 | 0.735 |
| R-HSA-192823 | Viral mRNA Translation | 0.232902 | 0.633 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.252216 | 0.598 |
| R-HSA-1989781 | PPARA activates gene expression | 0.247158 | 0.607 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.315960 | 0.500 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.315960 | 0.500 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.274778 | 0.561 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.274778 | 0.561 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.253469 | 0.596 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.055821 | 1.253 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.055821 | 1.253 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.285299 | 0.545 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.097827 | 1.010 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.055821 | 1.253 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.148354 | 0.829 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.354813 | 0.450 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.271752 | 0.566 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.028877 | 1.539 |
| R-HSA-180292 | GAB1 signalosome | 0.285299 | 0.545 |
| R-HSA-198203 | PI3K/AKT activation | 0.172870 | 0.762 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.242280 | 0.616 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 0.253271 | 0.596 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.325886 | 0.487 |
| R-HSA-156902 | Peptide chain elongation | 0.169847 | 0.770 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.192252 | 0.716 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.271752 | 0.566 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.121185 | 0.917 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.354813 | 0.450 |
| R-HSA-163680 | AMPK inhibits chREBP transcriptional activation activity | 0.013611 | 1.866 |
| R-HSA-69091 | Polymerase switching | 0.208332 | 0.681 |
| R-HSA-69109 | Leading Strand Synthesis | 0.208332 | 0.681 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.264103 | 0.578 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.295669 | 0.529 |
| R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | 0.084514 | 1.073 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.126009 | 0.900 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.140741 | 0.852 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.202636 | 0.693 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.097130 | 1.013 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.097130 | 1.013 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 0.208332 | 0.681 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.231128 | 0.636 |
| R-HSA-9673324 | WNT5:FZD7-mediated leishmania damping | 0.253271 | 0.596 |
| R-HSA-9664420 | Killing mechanisms | 0.253271 | 0.596 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.264103 | 0.578 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.098057 | 1.009 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.256107 | 0.592 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.041798 | 1.379 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.091419 | 1.039 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.091419 | 1.039 |
| R-HSA-9613354 | Lipophagy | 0.160701 | 0.794 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.202636 | 0.693 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.291447 | 0.535 |
| R-HSA-74749 | Signal attenuation | 0.015823 | 1.801 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.060911 | 1.215 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.315088 | 0.502 |
| R-HSA-4791275 | Signaling by WNT in cancer | 0.107008 | 0.971 |
| R-HSA-74751 | Insulin receptor signalling cascade | 0.282939 | 0.548 |
| R-HSA-194138 | Signaling by VEGF | 0.335036 | 0.475 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.160701 | 0.794 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.114267 | 0.942 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.048612 | 1.313 |
| R-HSA-167169 | HIV Transcription Elongation | 0.032221 | 1.492 |
| R-HSA-5693538 | Homology Directed Repair | 0.045540 | 1.342 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.072959 | 1.137 |
| R-HSA-373756 | SDK interactions | 0.028767 | 1.541 |
| R-HSA-194306 | Neurophilin interactions with VEGF and VEGFR | 0.056710 | 1.246 |
| R-HSA-3371378 | Regulation by c-FLIP | 0.148354 | 0.829 |
| R-HSA-9762292 | Regulation of CDH11 function | 0.172870 | 0.762 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 0.172870 | 0.762 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.172870 | 0.762 |
| R-HSA-4839744 | Signaling by APC mutants | 0.184863 | 0.733 |
| R-HSA-4839735 | Signaling by AXIN mutants | 0.196683 | 0.706 |
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 0.264103 | 0.578 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.135789 | 0.867 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.181567 | 0.741 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.202636 | 0.693 |
| R-HSA-9843745 | Adipogenesis | 0.169234 | 0.772 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.066351 | 1.178 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 0.253271 | 0.596 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.187875 | 0.726 |
| R-HSA-9851151 | MDK and PTN in ALK signaling | 0.083852 | 1.076 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 0.274778 | 0.561 |
| R-HSA-167172 | Transcription of the HIV genome | 0.026085 | 1.584 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.242280 | 0.616 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.135826 | 0.867 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.080210 | 1.096 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.116409 | 0.934 |
| R-HSA-9909396 | Circadian clock | 0.067336 | 1.172 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.044341 | 1.353 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.026051 | 1.584 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.042509 | 1.372 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.285299 | 0.545 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.033965 | 1.469 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.100997 | 0.996 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.110217 | 0.958 |
| R-HSA-69416 | Dimerization of procaspase-8 | 0.148354 | 0.829 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.016250 | 1.789 |
| R-HSA-191859 | snRNP Assembly | 0.075874 | 1.120 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.075874 | 1.120 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 0.295669 | 0.529 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.266805 | 0.574 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.256107 | 0.592 |
| R-HSA-68875 | Mitotic Prophase | 0.134172 | 0.872 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.093325 | 1.030 |
| R-HSA-169893 | Prolonged ERK activation events | 0.253271 | 0.596 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.113098 | 0.947 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.229072 | 0.640 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.070720 | 1.150 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.304968 | 0.516 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.111682 | 0.952 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.107148 | 0.970 |
| R-HSA-9842663 | Signaling by LTK | 0.208332 | 0.681 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.126009 | 0.900 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 0.080210 | 1.096 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.122518 | 0.912 |
| R-HSA-73886 | Chromosome Maintenance | 0.315203 | 0.501 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.028932 | 1.539 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.121185 | 0.917 |
| R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse | 0.305888 | 0.514 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.100997 | 0.996 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.111061 | 0.954 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.225255 | 0.647 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.323136 | 0.491 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.031152 | 1.507 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.315960 | 0.500 |
| R-HSA-73894 | DNA Repair | 0.320266 | 0.494 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.051672 | 1.287 |
| R-HSA-9854907 | Regulation of MITF-M dependent genes involved in metabolism | 0.070380 | 1.153 |
| R-HSA-390696 | Adrenoceptors | 0.011546 | 1.938 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.110217 | 0.958 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.026051 | 1.584 |
| R-HSA-425381 | Bicarbonate transporters | 0.184863 | 0.733 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.150759 | 0.822 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.150759 | 0.822 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.155820 | 0.807 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.325886 | 0.487 |
| R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes | 0.354813 | 0.450 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.236744 | 0.626 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.256107 | 0.592 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.325741 | 0.487 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.336350 | 0.473 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.244460 | 0.612 |
| R-HSA-9659379 | Sensory processing of sound | 0.135505 | 0.868 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.033965 | 1.469 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.138823 | 0.858 |
| R-HSA-165159 | MTOR signalling | 0.166036 | 0.780 |
| R-HSA-9675135 | Diseases of DNA repair | 0.186791 | 0.729 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.119113 | 0.924 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.110217 | 0.958 |
| R-HSA-419408 | Lysosphingolipid and LPA receptors | 0.242280 | 0.616 |
| R-HSA-1483148 | Synthesis of PG | 0.264103 | 0.578 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.140741 | 0.852 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.315960 | 0.500 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.186791 | 0.729 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.236744 | 0.626 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.325741 | 0.487 |
| R-HSA-416476 | G alpha (q) signalling events | 0.236614 | 0.626 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.354845 | 0.450 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.041421 | 1.383 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.123114 | 0.910 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.295399 | 0.530 |
| R-HSA-162587 | HIV Life Cycle | 0.044777 | 1.349 |
| R-HSA-73884 | Base Excision Repair | 0.176997 | 0.752 |
| R-HSA-199991 | Membrane Trafficking | 0.067484 | 1.171 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.274778 | 0.561 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.052256 | 1.282 |
| R-HSA-442720 | CREB1 phosphorylation through the activation of Adenylate Cyclase | 0.219813 | 0.658 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.145732 | 0.836 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.285299 | 0.545 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.128953 | 0.890 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.293680 | 0.532 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.295399 | 0.530 |
| R-HSA-162906 | HIV Infection | 0.155022 | 0.810 |
| R-HSA-9707616 | Heme signaling | 0.020063 | 1.698 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.252216 | 0.598 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.232228 | 0.634 |
| R-HSA-162582 | Signal Transduction | 0.249445 | 0.603 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.018177 | 1.740 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.014986 | 1.824 |
| R-HSA-525793 | Myogenesis | 0.080210 | 1.096 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.274778 | 0.561 |
| R-HSA-111931 | PKA-mediated phosphorylation of CREB | 0.315960 | 0.500 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.325886 | 0.487 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.272185 | 0.565 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.252216 | 0.598 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.271752 | 0.566 |
| R-HSA-74160 | Gene expression (Transcription) | 0.050713 | 1.295 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.299482 | 0.524 |
| R-HSA-9614657 | FOXO-mediated transcription of cell death genes | 0.045066 | 1.346 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 0.335669 | 0.474 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.331052 | 0.480 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.357470 | 0.447 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.327103 | 0.485 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.166305 | 0.779 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.135826 | 0.867 |
| R-HSA-418889 | Caspase activation via Dependence Receptors in the absence of ligand | 0.160701 | 0.794 |
| R-HSA-71384 | Ethanol oxidation | 0.335669 | 0.474 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.239926 | 0.620 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.229072 | 0.640 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.021000 | 1.678 |
| R-HSA-201556 | Signaling by ALK | 0.145732 | 0.836 |
| R-HSA-168255 | Influenza Infection | 0.165413 | 0.781 |
| R-HSA-1640170 | Cell Cycle | 0.069926 | 1.155 |
| R-HSA-1483166 | Synthesis of PA | 0.245295 | 0.610 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.282939 | 0.548 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.346928 | 0.460 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 0.038282 | 1.417 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.088792 | 1.052 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.065731 | 1.182 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.041621 | 1.381 |
| R-HSA-2586552 | Signaling by Leptin | 0.172870 | 0.762 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.325886 | 0.487 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.180603 | 0.743 |
| R-HSA-9629569 | Protein hydroxylation | 0.305888 | 0.514 |
| R-HSA-200425 | Carnitine shuttle | 0.345311 | 0.462 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.039677 | 1.401 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.153102 | 0.815 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.097827 | 1.010 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.295669 | 0.529 |
| R-HSA-445144 | Signal transduction by L1 | 0.305888 | 0.514 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.272185 | 0.565 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.187875 | 0.726 |
| R-HSA-212436 | Generic Transcription Pathway | 0.357465 | 0.447 |
| R-HSA-375280 | Amine ligand-binding receptors | 0.176365 | 0.754 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.325886 | 0.487 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.345311 | 0.462 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.217658 | 0.662 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.027435 | 1.562 |
| R-HSA-9022699 | MECP2 regulates neuronal receptors and channels | 0.080210 | 1.096 |
| R-HSA-211000 | Gene Silencing by RNA | 0.252216 | 0.598 |
| R-HSA-1538133 | G0 and Early G1 | 0.107008 | 0.971 |
| R-HSA-9833110 | RSV-host interactions | 0.240597 | 0.619 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.262997 | 0.580 |
| R-HSA-163685 | Integration of energy metabolism | 0.186406 | 0.730 |
| R-HSA-2028269 | Signaling by Hippo | 0.041621 | 1.381 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.242280 | 0.616 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.295669 | 0.529 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.341637 | 0.466 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.031848 | 1.497 |
| R-HSA-449836 | Other interleukin signaling | 0.295669 | 0.529 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.121185 | 0.917 |
| R-HSA-422475 | Axon guidance | 0.314389 | 0.503 |
| R-HSA-73887 | Death Receptor Signaling | 0.109096 | 0.962 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.343032 | 0.465 |
| R-HSA-2262752 | Cellular responses to stress | 0.348791 | 0.457 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.135789 | 0.867 |
| R-HSA-982772 | Growth hormone receptor signaling | 0.345311 | 0.462 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.189322 | 0.723 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.341637 | 0.466 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.078881 | 1.103 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.239926 | 0.620 |
| R-HSA-1474165 | Reproduction | 0.358799 | 0.445 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.364178 | 0.439 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.364178 | 0.439 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.364178 | 0.439 |
| R-HSA-9839394 | TGFBR3 expression | 0.364178 | 0.439 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.364178 | 0.439 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.364178 | 0.439 |
| R-HSA-400685 | Sema4D in semaphorin signaling | 0.364178 | 0.439 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.364178 | 0.439 |
| R-HSA-9620244 | Long-term potentiation | 0.364178 | 0.439 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.364178 | 0.439 |
| R-HSA-1266695 | Interleukin-7 signaling | 0.364178 | 0.439 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.373054 | 0.428 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.373407 | 0.428 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.373407 | 0.428 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.373407 | 0.428 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.373407 | 0.428 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.373407 | 0.428 |
| R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane | 0.373407 | 0.428 |
| R-HSA-3295583 | TRP channels | 0.373407 | 0.428 |
| R-HSA-70635 | Urea cycle | 0.373407 | 0.428 |
| R-HSA-9845614 | Sphingolipid catabolism | 0.373407 | 0.428 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.382503 | 0.417 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.383396 | 0.416 |
| R-HSA-9609690 | HCMV Early Events | 0.383772 | 0.416 |
| R-HSA-9675108 | Nervous system development | 0.385726 | 0.414 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.386367 | 0.413 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.388539 | 0.411 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.391468 | 0.407 |
| R-HSA-77387 | Insulin receptor recycling | 0.391468 | 0.407 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.391468 | 0.407 |
| R-HSA-73614 | Pyrimidine salvage | 0.391468 | 0.407 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.393664 | 0.405 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.396884 | 0.401 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.396884 | 0.401 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.398102 | 0.400 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.398769 | 0.399 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.398769 | 0.399 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.400303 | 0.398 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.400303 | 0.398 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.403855 | 0.394 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.409010 | 0.388 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.409010 | 0.388 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.409010 | 0.388 |
| R-HSA-182971 | EGFR downregulation | 0.417591 | 0.379 |
| R-HSA-9913351 | Formation of the dystrophin-glycoprotein complex (DGC) | 0.417591 | 0.379 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 0.417591 | 0.379 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.426049 | 0.371 |
| R-HSA-69190 | DNA strand elongation | 0.426049 | 0.371 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.426049 | 0.371 |
| R-HSA-1266738 | Developmental Biology | 0.428667 | 0.368 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.429077 | 0.367 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.432911 | 0.364 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.433921 | 0.363 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.434383 | 0.362 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.434383 | 0.362 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.434383 | 0.362 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.434383 | 0.362 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.434383 | 0.362 |
| R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol | 0.434383 | 0.362 |
| R-HSA-69242 | S Phase | 0.436736 | 0.360 |
| R-HSA-166520 | Signaling by NTRKs | 0.436736 | 0.360 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.438854 | 0.358 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.442345 | 0.354 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.442454 | 0.354 |
| R-HSA-390522 | Striated Muscle Contraction | 0.442598 | 0.354 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.442598 | 0.354 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.442598 | 0.354 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.442598 | 0.354 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.442598 | 0.354 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.444356 | 0.352 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.448649 | 0.348 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.450694 | 0.346 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.450694 | 0.346 |
| R-HSA-5673000 | RAF activation | 0.450694 | 0.346 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.450694 | 0.346 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.451936 | 0.345 |
| R-HSA-68882 | Mitotic Anaphase | 0.451965 | 0.345 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.455161 | 0.342 |
| R-HSA-187687 | Signalling to ERKs | 0.458672 | 0.338 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.458672 | 0.338 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.463160 | 0.334 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.463160 | 0.334 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.466535 | 0.331 |
| R-HSA-163560 | Triglyceride catabolism | 0.466535 | 0.331 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 0.466535 | 0.331 |
| R-HSA-111933 | Calmodulin induced events | 0.466535 | 0.331 |
| R-HSA-111997 | CaM pathway | 0.466535 | 0.331 |
| R-HSA-157579 | Telomere Maintenance | 0.467947 | 0.330 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.467947 | 0.330 |
| R-HSA-9610379 | HCMV Late Events | 0.470697 | 0.327 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.474285 | 0.324 |
| R-HSA-419037 | NCAM1 interactions | 0.474285 | 0.324 |
| R-HSA-8948216 | Collagen chain trimerization | 0.474285 | 0.324 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.474285 | 0.324 |
| R-HSA-9711097 | Cellular response to starvation | 0.474415 | 0.324 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.481815 | 0.317 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.481922 | 0.317 |
| R-HSA-9958790 | SLC-mediated transport of inorganic anions | 0.481922 | 0.317 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.482156 | 0.317 |
| R-HSA-70171 | Glycolysis | 0.482156 | 0.317 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.483627 | 0.315 |
| R-HSA-1483257 | Phospholipid metabolism | 0.487303 | 0.312 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.487532 | 0.312 |
| R-HSA-109581 | Apoptosis | 0.489166 | 0.311 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.489449 | 0.310 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.491498 | 0.308 |
| R-HSA-1483255 | PI Metabolism | 0.491498 | 0.308 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.491498 | 0.308 |
| R-HSA-195721 | Signaling by WNT | 0.495579 | 0.305 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.496467 | 0.304 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.496867 | 0.304 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.496867 | 0.304 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.496867 | 0.304 |
| R-HSA-5260271 | Diseases of Immune System | 0.496867 | 0.304 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.496867 | 0.304 |
| R-HSA-72312 | rRNA processing | 0.502277 | 0.299 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.504177 | 0.297 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.504177 | 0.297 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.504177 | 0.297 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.504177 | 0.297 |
| R-HSA-9694548 | Maturation of spike protein | 0.504177 | 0.297 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.504177 | 0.297 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.508429 | 0.294 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.511382 | 0.291 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.511382 | 0.291 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.511382 | 0.291 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.511382 | 0.291 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.511382 | 0.291 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.511382 | 0.291 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.511382 | 0.291 |
| R-HSA-8939211 | ESR-mediated signaling | 0.517593 | 0.286 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.518483 | 0.285 |
| R-HSA-73928 | Depyrimidination | 0.518483 | 0.285 |
| R-HSA-111996 | Ca-dependent events | 0.518483 | 0.285 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.521599 | 0.283 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.523935 | 0.281 |
| R-HSA-8854214 | TBC/RABGAPs | 0.525480 | 0.279 |
| R-HSA-157118 | Signaling by NOTCH | 0.526678 | 0.278 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.527789 | 0.278 |
| R-HSA-373752 | Netrin-1 signaling | 0.532377 | 0.274 |
| R-HSA-3214858 | RMTs methylate histone arginines | 0.532377 | 0.274 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.535652 | 0.271 |
| R-HSA-68886 | M Phase | 0.536885 | 0.270 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.539129 | 0.268 |
| R-HSA-774815 | Nucleosome assembly | 0.539174 | 0.268 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.539174 | 0.268 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.539174 | 0.268 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.539174 | 0.268 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 0.539174 | 0.268 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.539174 | 0.268 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.545872 | 0.263 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.545872 | 0.263 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.545872 | 0.263 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.545872 | 0.263 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.545872 | 0.263 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.545872 | 0.263 |
| R-HSA-75153 | Apoptotic execution phase | 0.545872 | 0.263 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.549568 | 0.260 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.552473 | 0.258 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.552473 | 0.258 |
| R-HSA-4839726 | Chromatin organization | 0.553426 | 0.257 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.554596 | 0.256 |
| R-HSA-2559583 | Cellular Senescence | 0.556288 | 0.255 |
| R-HSA-9609646 | HCMV Infection | 0.556349 | 0.255 |
| R-HSA-8963899 | Plasma lipoprotein remodeling | 0.558979 | 0.253 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.558979 | 0.253 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.558979 | 0.253 |
| R-HSA-73893 | DNA Damage Bypass | 0.565391 | 0.248 |
| R-HSA-9766229 | Degradation of CDH1 | 0.565391 | 0.248 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.566400 | 0.247 |
| R-HSA-70326 | Glucose metabolism | 0.570635 | 0.244 |
| R-HSA-109704 | PI3K Cascade | 0.571710 | 0.243 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.573671 | 0.241 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.574762 | 0.241 |
| R-HSA-912446 | Meiotic recombination | 0.577937 | 0.238 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.579361 | 0.237 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.580319 | 0.236 |
| R-HSA-72187 | mRNA 3'-end processing | 0.584074 | 0.234 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.584074 | 0.234 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.584074 | 0.234 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.584074 | 0.234 |
| R-HSA-983712 | Ion channel transport | 0.586198 | 0.232 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.586971 | 0.231 |
| R-HSA-3371556 | Cellular response to heat stress | 0.586971 | 0.231 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.590123 | 0.229 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.596083 | 0.225 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.607151 | 0.217 |
| R-HSA-177929 | Signaling by EGFR | 0.607747 | 0.216 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.610070 | 0.215 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.613453 | 0.212 |
| R-HSA-112399 | IRS-mediated signalling | 0.613453 | 0.212 |
| R-HSA-69481 | G2/M Checkpoints | 0.614445 | 0.212 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.619075 | 0.208 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.619075 | 0.208 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.622114 | 0.206 |
| R-HSA-8979227 | Triglyceride metabolism | 0.624617 | 0.204 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.624617 | 0.204 |
| R-HSA-180786 | Extension of Telomeres | 0.624617 | 0.204 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.624617 | 0.204 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.627076 | 0.203 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 0.630078 | 0.201 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.630078 | 0.201 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.630104 | 0.201 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.630104 | 0.201 |
| R-HSA-446728 | Cell junction organization | 0.633802 | 0.198 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.635460 | 0.197 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.635460 | 0.197 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.635460 | 0.197 |
| R-HSA-8956321 | Nucleotide salvage | 0.635460 | 0.197 |
| R-HSA-112043 | PLC beta mediated events | 0.635460 | 0.197 |
| R-HSA-1442490 | Collagen degradation | 0.635460 | 0.197 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.636868 | 0.196 |
| R-HSA-5357801 | Programmed Cell Death | 0.639085 | 0.194 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.640764 | 0.193 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.640764 | 0.193 |
| R-HSA-9658195 | Leishmania infection | 0.641568 | 0.193 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.641568 | 0.193 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.644133 | 0.191 |
| R-HSA-8848021 | Signaling by PTK6 | 0.645991 | 0.190 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.645991 | 0.190 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.645991 | 0.190 |
| R-HSA-373755 | Semaphorin interactions | 0.645991 | 0.190 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.651143 | 0.186 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.654766 | 0.184 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.656219 | 0.183 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.656219 | 0.183 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.659445 | 0.181 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.666153 | 0.176 |
| R-HSA-112040 | G-protein mediated events | 0.666153 | 0.176 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.668574 | 0.175 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.668574 | 0.175 |
| R-HSA-9664407 | Parasite infection | 0.668574 | 0.175 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 0.671013 | 0.173 |
| R-HSA-5218859 | Regulated Necrosis | 0.671013 | 0.173 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.671956 | 0.173 |
| R-HSA-1632852 | Macroautophagy | 0.671956 | 0.173 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.676375 | 0.170 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.678636 | 0.168 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.680521 | 0.167 |
| R-HSA-204005 | COPII-mediated vesicle transport | 0.680521 | 0.167 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.680521 | 0.167 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.680521 | 0.167 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.685172 | 0.164 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.689755 | 0.161 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.689755 | 0.161 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.689755 | 0.161 |
| R-HSA-4086398 | Ca2+ pathway | 0.694272 | 0.158 |
| R-HSA-1280218 | Adaptive Immune System | 0.696994 | 0.157 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.698724 | 0.156 |
| R-HSA-9758941 | Gastrulation | 0.701149 | 0.154 |
| R-HSA-8852135 | Protein ubiquitination | 0.703111 | 0.153 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.703111 | 0.153 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.704090 | 0.152 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.707337 | 0.150 |
| R-HSA-9824446 | Viral Infection Pathways | 0.707560 | 0.150 |
| R-HSA-8953854 | Metabolism of RNA | 0.708707 | 0.150 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.711695 | 0.148 |
| R-HSA-69306 | DNA Replication | 0.713419 | 0.147 |
| R-HSA-4086400 | PCP/CE pathway | 0.715894 | 0.145 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.715894 | 0.145 |
| R-HSA-216083 | Integrin cell surface interactions | 0.715894 | 0.145 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.716420 | 0.145 |
| R-HSA-9612973 | Autophagy | 0.722343 | 0.141 |
| R-HSA-1500931 | Cell-Cell communication | 0.724081 | 0.140 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.724110 | 0.140 |
| R-HSA-388396 | GPCR downstream signalling | 0.727434 | 0.138 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.738779 | 0.131 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.739840 | 0.131 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.739840 | 0.131 |
| R-HSA-8957322 | Metabolism of steroids | 0.740830 | 0.130 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.743630 | 0.129 |
| R-HSA-1500620 | Meiosis | 0.743630 | 0.129 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.743630 | 0.129 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.745003 | 0.128 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.747366 | 0.126 |
| R-HSA-163841 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation | 0.751048 | 0.124 |
| R-HSA-5619102 | SLC transporter disorders | 0.753085 | 0.123 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.754676 | 0.122 |
| R-HSA-421270 | Cell-cell junction organization | 0.757689 | 0.121 |
| R-HSA-9663891 | Selective autophagy | 0.758251 | 0.120 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.761775 | 0.118 |
| R-HSA-72306 | tRNA processing | 0.763518 | 0.117 |
| R-HSA-5688426 | Deubiquitination | 0.766349 | 0.116 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.768669 | 0.114 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.771091 | 0.113 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.771091 | 0.113 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.771091 | 0.113 |
| R-HSA-391251 | Protein folding | 0.775365 | 0.110 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.775365 | 0.110 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.775365 | 0.110 |
| R-HSA-1474290 | Collagen formation | 0.781867 | 0.107 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.782915 | 0.106 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.806057 | 0.094 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.814316 | 0.089 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.814422 | 0.089 |
| R-HSA-111885 | Opioid Signalling | 0.814422 | 0.089 |
| R-HSA-68877 | Mitotic Prometaphase | 0.816376 | 0.088 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.818416 | 0.087 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.822435 | 0.085 |
| R-HSA-69239 | Synthesis of DNA | 0.825020 | 0.084 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.827573 | 0.082 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.827573 | 0.082 |
| R-HSA-372790 | Signaling by GPCR | 0.828920 | 0.081 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.830188 | 0.081 |
| R-HSA-72172 | mRNA Splicing | 0.839553 | 0.076 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.839797 | 0.076 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.841311 | 0.075 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.848951 | 0.071 |
| R-HSA-373760 | L1CAM interactions | 0.851157 | 0.070 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.853331 | 0.069 |
| R-HSA-397014 | Muscle contraction | 0.853504 | 0.069 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.857194 | 0.067 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.857584 | 0.067 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.857584 | 0.067 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.857584 | 0.067 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.861714 | 0.065 |
| R-HSA-418990 | Adherens junctions interactions | 0.863235 | 0.064 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.863735 | 0.064 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.863735 | 0.064 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.867688 | 0.062 |
| R-HSA-8951664 | Neddylation | 0.867876 | 0.062 |
| R-HSA-69206 | G1/S Transition | 0.871526 | 0.060 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.873404 | 0.059 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.878149 | 0.056 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.880947 | 0.055 |
| R-HSA-5576891 | Cardiac conduction | 0.884109 | 0.053 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 0.885803 | 0.053 |
| R-HSA-1474244 | Extracellular matrix organization | 0.887954 | 0.052 |
| R-HSA-15869 | Metabolism of nucleotides | 0.888988 | 0.051 |
| R-HSA-72766 | Translation | 0.896011 | 0.048 |
| R-HSA-6807070 | PTEN Regulation | 0.898500 | 0.046 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.902441 | 0.045 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.906838 | 0.042 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.912411 | 0.040 |
| R-HSA-5663205 | Infectious disease | 0.919501 | 0.036 |
| R-HSA-112316 | Neuronal System | 0.928101 | 0.032 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.940323 | 0.027 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.940323 | 0.027 |
| R-HSA-375276 | Peptide ligand-binding receptors | 0.950752 | 0.022 |
| R-HSA-69275 | G2/M Transition | 0.950752 | 0.022 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.952187 | 0.021 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.954261 | 0.020 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.957830 | 0.019 |
| R-HSA-428157 | Sphingolipid metabolism | 0.960550 | 0.017 |
| R-HSA-6805567 | Keratinization | 0.963902 | 0.016 |
| R-HSA-6798695 | Neutrophil degranulation | 0.971485 | 0.013 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.976801 | 0.010 |
| R-HSA-556833 | Metabolism of lipids | 0.977674 | 0.010 |
| R-HSA-500792 | GPCR ligand binding | 0.979025 | 0.009 |
| R-HSA-913531 | Interferon Signaling | 0.982017 | 0.008 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.984644 | 0.007 |
| R-HSA-449147 | Signaling by Interleukins | 0.985769 | 0.006 |
| R-HSA-418594 | G alpha (i) signalling events | 0.986791 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 0.986791 | 0.006 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.987595 | 0.005 |
| R-HSA-597592 | Post-translational protein modification | 0.988234 | 0.005 |
| R-HSA-1643685 | Disease | 0.990238 | 0.004 |
| R-HSA-9679506 | SARS-CoV Infections | 0.990887 | 0.004 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.992933 | 0.003 |
| R-HSA-168256 | Immune System | 0.997163 | 0.001 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.997931 | 0.001 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.998939 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999122 | 0.000 |
| R-HSA-109582 | Hemostasis | 0.999478 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999565 | 0.000 |
| R-HSA-211859 | Biological oxidations | 0.999689 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.999796 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.889 | 0.103 | 1 | 0.859 |
TAK1 |
0.877 | -0.000 | 1 | 0.846 |
PKR |
0.876 | 0.031 | 1 | 0.877 |
GCK |
0.876 | 0.078 | 1 | 0.836 |
VRK2 |
0.876 | -0.166 | 1 | 0.910 |
LRRK2 |
0.874 | -0.074 | 2 | 0.794 |
VRK1 |
0.872 | -0.146 | 2 | 0.787 |
MINK |
0.871 | -0.032 | 1 | 0.821 |
NIK |
0.870 | 0.073 | -3 | 0.902 |
DAPK2 |
0.870 | 0.118 | -3 | 0.892 |
TNIK |
0.869 | -0.011 | 3 | 0.874 |
CAMLCK |
0.869 | 0.134 | -2 | 0.827 |
PASK |
0.869 | 0.192 | -3 | 0.873 |
TTK |
0.868 | -0.020 | -2 | 0.795 |
LKB1 |
0.868 | -0.008 | -3 | 0.853 |
KHS2 |
0.868 | 0.077 | 1 | 0.827 |
NEK1 |
0.867 | -0.108 | 1 | 0.828 |
HPK1 |
0.867 | 0.057 | 1 | 0.819 |
KHS1 |
0.866 | 0.016 | 1 | 0.811 |
MEK1 |
0.866 | -0.143 | 2 | 0.792 |
DMPK1 |
0.866 | 0.181 | -3 | 0.799 |
BMPR2 |
0.865 | -0.117 | -2 | 0.834 |
LATS1 |
0.865 | 0.133 | -3 | 0.862 |
BRAF |
0.865 | -0.090 | -4 | 0.854 |
EEF2K |
0.865 | -0.034 | 3 | 0.858 |
MST3 |
0.864 | 0.053 | 2 | 0.776 |
MEK5 |
0.864 | -0.192 | 2 | 0.768 |
MST1 |
0.864 | -0.099 | 1 | 0.823 |
HGK |
0.864 | -0.058 | 3 | 0.875 |
ALK4 |
0.864 | 0.037 | -2 | 0.789 |
ALPHAK3 |
0.864 | 0.003 | -1 | 0.802 |
TAO2 |
0.864 | -0.101 | 2 | 0.783 |
MOS |
0.863 | 0.188 | 1 | 0.904 |
TAO3 |
0.863 | -0.006 | 1 | 0.837 |
NEK5 |
0.863 | -0.101 | 1 | 0.845 |
MST2 |
0.862 | -0.104 | 1 | 0.837 |
ASK1 |
0.862 | -0.199 | 1 | 0.776 |
CAMKK2 |
0.862 | -0.097 | -2 | 0.725 |
MEKK2 |
0.862 | -0.126 | 2 | 0.737 |
JNK2 |
0.862 | 0.237 | 1 | 0.731 |
NLK |
0.862 | 0.194 | 1 | 0.913 |
CAMKK1 |
0.861 | -0.109 | -2 | 0.731 |
DAPK3 |
0.861 | 0.140 | -3 | 0.835 |
CAMK1B |
0.861 | 0.119 | -3 | 0.891 |
DLK |
0.861 | -0.034 | 1 | 0.867 |
CDKL1 |
0.861 | 0.155 | -3 | 0.837 |
ICK |
0.860 | 0.181 | -3 | 0.864 |
MYO3B |
0.860 | -0.056 | 2 | 0.755 |
MEKK6 |
0.860 | -0.106 | 1 | 0.833 |
MAP3K15 |
0.859 | -0.143 | 1 | 0.789 |
SMMLCK |
0.859 | 0.103 | -3 | 0.851 |
PDK1 |
0.859 | -0.132 | 1 | 0.795 |
ROCK2 |
0.859 | 0.142 | -3 | 0.820 |
ALK2 |
0.859 | 0.090 | -2 | 0.785 |
OSR1 |
0.859 | -0.089 | 2 | 0.734 |
PRPK |
0.858 | -0.082 | -1 | 0.895 |
PBK |
0.858 | -0.020 | 1 | 0.767 |
MPSK1 |
0.857 | 0.033 | 1 | 0.813 |
JNK3 |
0.857 | 0.204 | 1 | 0.761 |
BIKE |
0.857 | -0.042 | 1 | 0.716 |
NEK8 |
0.857 | -0.125 | 2 | 0.761 |
MYO3A |
0.857 | -0.100 | 1 | 0.826 |
SKMLCK |
0.857 | 0.179 | -2 | 0.832 |
NEK11 |
0.857 | -0.112 | 1 | 0.808 |
NEK4 |
0.856 | -0.122 | 1 | 0.821 |
MEKK3 |
0.855 | -0.044 | 1 | 0.835 |
PRP4 |
0.855 | 0.138 | -3 | 0.796 |
ANKRD3 |
0.855 | -0.142 | 1 | 0.863 |
BMPR1B |
0.854 | 0.186 | 1 | 0.838 |
YSK1 |
0.854 | -0.117 | 2 | 0.738 |
CLK3 |
0.853 | 0.379 | 1 | 0.927 |
P38A |
0.853 | 0.178 | 1 | 0.803 |
TGFBR1 |
0.852 | 0.063 | -2 | 0.763 |
YSK4 |
0.852 | -0.095 | 1 | 0.806 |
ATR |
0.852 | 0.001 | 1 | 0.846 |
MEKK1 |
0.851 | -0.219 | 1 | 0.832 |
DAPK1 |
0.851 | 0.145 | -3 | 0.823 |
P38B |
0.851 | 0.201 | 1 | 0.738 |
LOK |
0.851 | -0.049 | -2 | 0.731 |
MEK2 |
0.849 | -0.305 | 2 | 0.749 |
STLK3 |
0.849 | -0.253 | 1 | 0.783 |
RAF1 |
0.849 | 0.025 | 1 | 0.869 |
ACVR2B |
0.848 | 0.058 | -2 | 0.763 |
ZAK |
0.847 | -0.169 | 1 | 0.805 |
HIPK1 |
0.847 | 0.229 | 1 | 0.825 |
ACVR2A |
0.845 | 0.030 | -2 | 0.749 |
GRK7 |
0.845 | 0.157 | 1 | 0.814 |
ERK5 |
0.845 | 0.102 | 1 | 0.861 |
PIM1 |
0.844 | 0.172 | -3 | 0.820 |
MLK2 |
0.844 | -0.151 | 2 | 0.745 |
ROCK1 |
0.844 | 0.124 | -3 | 0.792 |
AAK1 |
0.844 | -0.005 | 1 | 0.610 |
GRK6 |
0.844 | 0.081 | 1 | 0.871 |
PERK |
0.843 | -0.145 | -2 | 0.801 |
WNK4 |
0.843 | -0.041 | -2 | 0.813 |
COT |
0.843 | 0.171 | 2 | 0.827 |
PLK1 |
0.843 | -0.021 | -2 | 0.775 |
MRCKA |
0.843 | 0.139 | -3 | 0.791 |
WNK1 |
0.843 | 0.096 | -2 | 0.824 |
MAK |
0.842 | 0.228 | -2 | 0.743 |
SLK |
0.842 | -0.045 | -2 | 0.685 |
RIPK1 |
0.842 | -0.043 | 1 | 0.833 |
BMPR1A |
0.842 | 0.121 | 1 | 0.816 |
PIM3 |
0.842 | 0.154 | -3 | 0.860 |
CAMK2G |
0.841 | 0.005 | 2 | 0.793 |
ERK2 |
0.841 | 0.147 | 1 | 0.784 |
DYRK2 |
0.841 | 0.234 | 1 | 0.808 |
TSSK2 |
0.841 | 0.051 | -5 | 0.871 |
HASPIN |
0.841 | 0.092 | -1 | 0.795 |
CLK4 |
0.841 | 0.246 | -3 | 0.810 |
CRIK |
0.840 | 0.145 | -3 | 0.742 |
BUB1 |
0.839 | 0.122 | -5 | 0.848 |
PIM2 |
0.839 | 0.135 | -3 | 0.787 |
GRK5 |
0.839 | -0.053 | -3 | 0.868 |
MLK1 |
0.839 | -0.086 | 2 | 0.749 |
RIPK3 |
0.839 | 0.047 | 3 | 0.774 |
P38G |
0.839 | 0.181 | 1 | 0.667 |
PKCD |
0.838 | 0.085 | 2 | 0.724 |
CHAK2 |
0.838 | -0.013 | -1 | 0.891 |
MRCKB |
0.838 | 0.128 | -3 | 0.781 |
MOK |
0.838 | 0.194 | 1 | 0.823 |
CDC7 |
0.837 | 0.116 | 1 | 0.873 |
AMPKA1 |
0.837 | 0.056 | -3 | 0.878 |
CDKL5 |
0.837 | 0.135 | -3 | 0.828 |
PDHK4 |
0.837 | -0.206 | 1 | 0.888 |
HRI |
0.837 | -0.222 | -2 | 0.796 |
IRAK4 |
0.837 | -0.083 | 1 | 0.827 |
PKN3 |
0.837 | 0.029 | -3 | 0.853 |
TLK2 |
0.837 | -0.112 | 1 | 0.826 |
P70S6KB |
0.836 | 0.122 | -3 | 0.833 |
MYLK4 |
0.836 | 0.152 | -2 | 0.763 |
MASTL |
0.836 | -0.254 | -2 | 0.772 |
TAO1 |
0.836 | -0.154 | 1 | 0.757 |
NUAK2 |
0.836 | 0.096 | -3 | 0.870 |
NEK9 |
0.836 | -0.197 | 2 | 0.768 |
CDK1 |
0.836 | 0.213 | 1 | 0.752 |
DCAMKL1 |
0.835 | 0.030 | -3 | 0.818 |
JNK1 |
0.835 | 0.167 | 1 | 0.720 |
DYRK1A |
0.835 | 0.183 | 1 | 0.843 |
P38D |
0.835 | 0.191 | 1 | 0.667 |
CDK14 |
0.834 | 0.193 | 1 | 0.759 |
TLK1 |
0.834 | -0.118 | -2 | 0.786 |
PKN2 |
0.834 | 0.082 | -3 | 0.867 |
CDK5 |
0.834 | 0.164 | 1 | 0.800 |
NEK2 |
0.833 | -0.116 | 2 | 0.746 |
HIPK3 |
0.833 | 0.173 | 1 | 0.817 |
TSSK1 |
0.833 | 0.074 | -3 | 0.892 |
MST4 |
0.833 | 0.059 | 2 | 0.787 |
MTOR |
0.833 | 0.056 | 1 | 0.841 |
DYRK3 |
0.833 | 0.229 | 1 | 0.823 |
DSTYK |
0.832 | 0.014 | 2 | 0.834 |
CHK1 |
0.832 | -0.007 | -3 | 0.835 |
RSK2 |
0.831 | 0.194 | -3 | 0.808 |
ERK1 |
0.831 | 0.166 | 1 | 0.727 |
PDHK1 |
0.830 | -0.256 | 1 | 0.870 |
AKT2 |
0.829 | 0.145 | -3 | 0.736 |
DNAPK |
0.829 | 0.031 | 1 | 0.697 |
DYRK1B |
0.829 | 0.196 | 1 | 0.769 |
GSK3B |
0.829 | 0.086 | 4 | 0.500 |
MLK3 |
0.829 | -0.037 | 2 | 0.670 |
SGK3 |
0.829 | 0.107 | -3 | 0.797 |
GRK2 |
0.829 | -0.003 | -2 | 0.704 |
HUNK |
0.829 | -0.046 | 2 | 0.767 |
SRPK1 |
0.828 | 0.207 | -3 | 0.791 |
MLK4 |
0.828 | -0.079 | 2 | 0.654 |
DRAK1 |
0.828 | -0.001 | 1 | 0.765 |
HIPK4 |
0.828 | 0.172 | 1 | 0.887 |
PAK2 |
0.828 | 0.055 | -2 | 0.767 |
P90RSK |
0.828 | 0.140 | -3 | 0.810 |
MARK4 |
0.828 | -0.008 | 4 | 0.852 |
DCAMKL2 |
0.827 | -0.026 | -3 | 0.840 |
ERK7 |
0.827 | 0.057 | 2 | 0.507 |
PINK1 |
0.827 | -0.144 | 1 | 0.884 |
PLK3 |
0.827 | -0.059 | 2 | 0.759 |
NEK3 |
0.827 | -0.209 | 1 | 0.781 |
GSK3A |
0.827 | 0.136 | 4 | 0.508 |
CLK1 |
0.827 | 0.233 | -3 | 0.788 |
TGFBR2 |
0.827 | -0.029 | -2 | 0.773 |
SRPK3 |
0.827 | 0.150 | -3 | 0.767 |
PAK1 |
0.827 | 0.096 | -2 | 0.777 |
AMPKA2 |
0.826 | 0.057 | -3 | 0.850 |
GRK1 |
0.826 | 0.182 | -2 | 0.814 |
DYRK4 |
0.826 | 0.250 | 1 | 0.740 |
CDK2 |
0.826 | 0.122 | 1 | 0.821 |
CDK4 |
0.825 | 0.147 | 1 | 0.725 |
WNK3 |
0.825 | -0.149 | 1 | 0.843 |
CAMK2D |
0.825 | 0.012 | -3 | 0.864 |
SGK1 |
0.825 | 0.132 | -3 | 0.656 |
CHAK1 |
0.824 | -0.129 | 2 | 0.703 |
AURB |
0.824 | 0.146 | -2 | 0.676 |
CLK2 |
0.824 | 0.332 | -3 | 0.790 |
MSK1 |
0.823 | 0.178 | -3 | 0.782 |
CAMK1D |
0.823 | 0.085 | -3 | 0.731 |
PKCZ |
0.823 | 0.019 | 2 | 0.713 |
CAMK4 |
0.823 | 0.010 | -3 | 0.850 |
ATM |
0.823 | -0.017 | 1 | 0.773 |
CHK2 |
0.823 | 0.079 | -3 | 0.682 |
CDK6 |
0.823 | 0.136 | 1 | 0.733 |
CAMK2B |
0.822 | 0.106 | 2 | 0.769 |
NEK7 |
0.822 | -0.149 | -3 | 0.856 |
HIPK2 |
0.822 | 0.237 | 1 | 0.731 |
PKCA |
0.822 | 0.042 | 2 | 0.661 |
IRE1 |
0.821 | -0.057 | 1 | 0.829 |
NDR1 |
0.821 | 0.082 | -3 | 0.858 |
IRE2 |
0.821 | -0.065 | 2 | 0.703 |
CAMK2A |
0.821 | 0.137 | 2 | 0.793 |
RSK4 |
0.821 | 0.195 | -3 | 0.777 |
MELK |
0.821 | 0.011 | -3 | 0.836 |
TBK1 |
0.821 | -0.103 | 1 | 0.749 |
SMG1 |
0.821 | -0.060 | 1 | 0.791 |
PKCH |
0.820 | 0.012 | 2 | 0.658 |
ULK2 |
0.819 | -0.205 | 2 | 0.730 |
PAK3 |
0.819 | 0.050 | -2 | 0.767 |
MAPKAPK3 |
0.819 | 0.060 | -3 | 0.803 |
AKT1 |
0.819 | 0.130 | -3 | 0.750 |
CDK10 |
0.819 | 0.213 | 1 | 0.743 |
CDK3 |
0.819 | 0.189 | 1 | 0.688 |
PRKD3 |
0.819 | 0.109 | -3 | 0.784 |
PKACG |
0.819 | 0.126 | -2 | 0.742 |
CDK17 |
0.818 | 0.163 | 1 | 0.672 |
PKCB |
0.818 | 0.049 | 2 | 0.667 |
CDK13 |
0.818 | 0.132 | 1 | 0.758 |
IRAK1 |
0.817 | -0.255 | -1 | 0.805 |
CAMK1G |
0.817 | 0.064 | -3 | 0.802 |
QIK |
0.817 | -0.038 | -3 | 0.862 |
NEK6 |
0.817 | -0.080 | -2 | 0.806 |
CDK16 |
0.817 | 0.170 | 1 | 0.689 |
CDK18 |
0.817 | 0.182 | 1 | 0.719 |
CDK12 |
0.816 | 0.143 | 1 | 0.733 |
AURA |
0.816 | 0.130 | -2 | 0.663 |
CDK7 |
0.816 | 0.135 | 1 | 0.783 |
RSK3 |
0.816 | 0.131 | -3 | 0.800 |
PKCG |
0.815 | 0.050 | 2 | 0.669 |
MSK2 |
0.815 | 0.106 | -3 | 0.780 |
PKCE |
0.814 | 0.076 | 2 | 0.656 |
IKKE |
0.814 | -0.116 | 1 | 0.747 |
SSTK |
0.814 | -0.003 | 4 | 0.813 |
GRK4 |
0.813 | -0.047 | -2 | 0.815 |
PKCI |
0.813 | 0.032 | 2 | 0.683 |
PKG2 |
0.813 | 0.109 | -2 | 0.680 |
QSK |
0.813 | 0.031 | 4 | 0.827 |
PKACB |
0.813 | 0.185 | -2 | 0.684 |
TTBK2 |
0.813 | -0.154 | 2 | 0.629 |
MARK2 |
0.813 | -0.024 | 4 | 0.757 |
PLK2 |
0.813 | -0.021 | -3 | 0.788 |
STK33 |
0.812 | -0.124 | 2 | 0.569 |
PDHK3_TYR |
0.812 | 0.255 | 4 | 0.911 |
RIPK2 |
0.812 | -0.253 | 1 | 0.749 |
CDK8 |
0.812 | 0.128 | 1 | 0.774 |
IKKB |
0.812 | -0.058 | -2 | 0.706 |
NIM1 |
0.812 | -0.076 | 3 | 0.812 |
PRKD1 |
0.812 | 0.100 | -3 | 0.842 |
SBK |
0.811 | 0.097 | -3 | 0.618 |
LATS2 |
0.811 | 0.061 | -5 | 0.795 |
MNK1 |
0.811 | 0.090 | -2 | 0.780 |
AURC |
0.811 | 0.175 | -2 | 0.676 |
CDK9 |
0.811 | 0.109 | 1 | 0.763 |
PRKD2 |
0.811 | 0.154 | -3 | 0.803 |
MARK1 |
0.810 | -0.024 | 4 | 0.808 |
MARK3 |
0.810 | 0.018 | 4 | 0.786 |
NDR2 |
0.809 | 0.100 | -3 | 0.860 |
P70S6K |
0.809 | 0.082 | -3 | 0.749 |
PKCT |
0.809 | 0.012 | 2 | 0.661 |
MNK2 |
0.808 | 0.080 | -2 | 0.769 |
SRPK2 |
0.808 | 0.175 | -3 | 0.719 |
CAMK1A |
0.807 | 0.077 | -3 | 0.699 |
MAPKAPK2 |
0.807 | 0.113 | -3 | 0.760 |
PDHK4_TYR |
0.807 | 0.203 | 2 | 0.859 |
PLK4 |
0.805 | -0.140 | 2 | 0.592 |
NUAK1 |
0.805 | 0.013 | -3 | 0.823 |
IKKA |
0.804 | -0.041 | -2 | 0.698 |
GCN2 |
0.804 | -0.177 | 2 | 0.757 |
ULK1 |
0.802 | -0.226 | -3 | 0.823 |
MAP2K6_TYR |
0.802 | 0.098 | -1 | 0.898 |
GRK3 |
0.802 | 0.001 | -2 | 0.676 |
CK1D |
0.801 | 0.069 | -3 | 0.531 |
TESK1_TYR |
0.801 | -0.001 | 3 | 0.901 |
MAP2K4_TYR |
0.801 | 0.016 | -1 | 0.898 |
SIK |
0.801 | 0.016 | -3 | 0.799 |
BMPR2_TYR |
0.800 | 0.100 | -1 | 0.887 |
PKACA |
0.800 | 0.144 | -2 | 0.635 |
AKT3 |
0.800 | 0.129 | -3 | 0.672 |
BCKDK |
0.799 | -0.173 | -1 | 0.827 |
CDK19 |
0.799 | 0.137 | 1 | 0.737 |
PDHK1_TYR |
0.798 | 0.043 | -1 | 0.900 |
PKMYT1_TYR |
0.797 | -0.067 | 3 | 0.871 |
MAP2K7_TYR |
0.797 | -0.139 | 2 | 0.817 |
LIMK2_TYR |
0.797 | 0.033 | -3 | 0.900 |
PRKX |
0.795 | 0.213 | -3 | 0.723 |
PHKG1 |
0.794 | -0.071 | -3 | 0.854 |
PAK6 |
0.794 | 0.095 | -2 | 0.707 |
CK1A2 |
0.794 | 0.044 | -3 | 0.534 |
SNRK |
0.793 | -0.158 | 2 | 0.650 |
CK2A2 |
0.793 | 0.096 | 1 | 0.731 |
PINK1_TYR |
0.793 | -0.159 | 1 | 0.879 |
YANK3 |
0.791 | -0.065 | 2 | 0.379 |
KIS |
0.791 | 0.225 | 1 | 0.799 |
PKN1 |
0.790 | 0.004 | -3 | 0.765 |
CK1E |
0.790 | 0.056 | -3 | 0.581 |
EPHA6 |
0.790 | 0.011 | -1 | 0.873 |
FAM20C |
0.789 | 0.071 | 2 | 0.598 |
BRSK2 |
0.789 | -0.075 | -3 | 0.845 |
BRSK1 |
0.788 | -0.017 | -3 | 0.824 |
MAPKAPK5 |
0.788 | -0.067 | -3 | 0.753 |
TXK |
0.787 | 0.108 | 1 | 0.858 |
LIMK1_TYR |
0.787 | -0.186 | 2 | 0.793 |
RET |
0.787 | -0.147 | 1 | 0.839 |
TTBK1 |
0.786 | -0.197 | 2 | 0.560 |
EPHB4 |
0.786 | -0.036 | -1 | 0.856 |
CK2A1 |
0.786 | 0.090 | 1 | 0.711 |
MST1R |
0.784 | -0.157 | 3 | 0.818 |
TYRO3 |
0.784 | -0.149 | 3 | 0.811 |
DDR1 |
0.782 | -0.152 | 4 | 0.821 |
PAK5 |
0.782 | 0.063 | -2 | 0.661 |
YES1 |
0.782 | -0.054 | -1 | 0.856 |
ROS1 |
0.781 | -0.176 | 3 | 0.781 |
ITK |
0.780 | -0.000 | -1 | 0.827 |
TNK2 |
0.780 | -0.038 | 3 | 0.760 |
FGR |
0.780 | -0.102 | 1 | 0.869 |
INSRR |
0.780 | -0.077 | 3 | 0.766 |
CSF1R |
0.780 | -0.132 | 3 | 0.796 |
EPHA4 |
0.780 | -0.020 | 2 | 0.768 |
FER |
0.779 | -0.124 | 1 | 0.890 |
SRMS |
0.779 | -0.029 | 1 | 0.875 |
YANK2 |
0.779 | -0.100 | 2 | 0.390 |
TYK2 |
0.778 | -0.300 | 1 | 0.828 |
ABL2 |
0.778 | -0.076 | -1 | 0.839 |
JAK3 |
0.777 | -0.146 | 1 | 0.809 |
LCK |
0.776 | -0.011 | -1 | 0.842 |
PHKG2 |
0.776 | -0.072 | -3 | 0.833 |
FGFR2 |
0.776 | -0.136 | 3 | 0.814 |
JAK2 |
0.776 | -0.263 | 1 | 0.826 |
EPHB1 |
0.776 | -0.078 | 1 | 0.864 |
BMX |
0.775 | 0.005 | -1 | 0.769 |
ABL1 |
0.775 | -0.096 | -1 | 0.831 |
HCK |
0.775 | -0.102 | -1 | 0.841 |
TNK1 |
0.775 | -0.098 | 3 | 0.793 |
BLK |
0.774 | 0.016 | -1 | 0.840 |
EPHB2 |
0.774 | -0.056 | -1 | 0.831 |
KIT |
0.774 | -0.122 | 3 | 0.806 |
TEK |
0.774 | -0.130 | 3 | 0.756 |
EPHB3 |
0.774 | -0.090 | -1 | 0.839 |
TEC |
0.773 | -0.037 | -1 | 0.780 |
NEK10_TYR |
0.773 | -0.124 | 1 | 0.723 |
PAK4 |
0.772 | 0.066 | -2 | 0.671 |
KDR |
0.772 | -0.121 | 3 | 0.761 |
MERTK |
0.771 | -0.102 | 3 | 0.779 |
AXL |
0.771 | -0.149 | 3 | 0.784 |
MET |
0.771 | -0.084 | 3 | 0.790 |
FYN |
0.770 | 0.025 | -1 | 0.819 |
WEE1_TYR |
0.770 | -0.082 | -1 | 0.807 |
FLT3 |
0.770 | -0.199 | 3 | 0.803 |
TNNI3K_TYR |
0.770 | -0.111 | 1 | 0.842 |
PDGFRB |
0.769 | -0.251 | 3 | 0.814 |
DDR2 |
0.768 | -0.019 | 3 | 0.751 |
FGFR1 |
0.768 | -0.208 | 3 | 0.774 |
PKG1 |
0.768 | 0.049 | -2 | 0.600 |
EPHA7 |
0.768 | -0.072 | 2 | 0.760 |
FLT1 |
0.767 | -0.102 | -1 | 0.832 |
BTK |
0.766 | -0.193 | -1 | 0.800 |
FGFR3 |
0.766 | -0.132 | 3 | 0.787 |
EPHA3 |
0.765 | -0.134 | 2 | 0.733 |
JAK1 |
0.764 | -0.179 | 1 | 0.759 |
PTK2B |
0.764 | -0.045 | -1 | 0.813 |
PTK6 |
0.764 | -0.235 | -1 | 0.770 |
ERBB2 |
0.763 | -0.170 | 1 | 0.792 |
ALK |
0.762 | -0.207 | 3 | 0.728 |
LTK |
0.762 | -0.190 | 3 | 0.748 |
EPHA5 |
0.761 | -0.062 | 2 | 0.755 |
FRK |
0.761 | -0.118 | -1 | 0.850 |
EPHA1 |
0.761 | -0.156 | 3 | 0.763 |
NTRK1 |
0.761 | -0.252 | -1 | 0.842 |
PTK2 |
0.760 | 0.039 | -1 | 0.782 |
PDGFRA |
0.760 | -0.326 | 3 | 0.812 |
LYN |
0.760 | -0.115 | 3 | 0.738 |
INSR |
0.759 | -0.207 | 3 | 0.745 |
MATK |
0.759 | -0.128 | -1 | 0.770 |
SRC |
0.758 | -0.072 | -1 | 0.815 |
FLT4 |
0.758 | -0.224 | 3 | 0.764 |
EPHA8 |
0.757 | -0.091 | -1 | 0.818 |
SYK |
0.757 | 0.052 | -1 | 0.775 |
NTRK2 |
0.756 | -0.279 | 3 | 0.767 |
NTRK3 |
0.754 | -0.199 | -1 | 0.799 |
EGFR |
0.753 | -0.111 | 1 | 0.700 |
CK1G1 |
0.752 | -0.030 | -3 | 0.572 |
CSK |
0.752 | -0.186 | 2 | 0.754 |
FGFR4 |
0.751 | -0.128 | -1 | 0.786 |
CK1G3 |
0.749 | -0.003 | -3 | 0.397 |
EPHA2 |
0.749 | -0.084 | -1 | 0.784 |
ERBB4 |
0.745 | -0.058 | 1 | 0.717 |
IGF1R |
0.745 | -0.182 | 3 | 0.696 |
MUSK |
0.738 | -0.220 | 1 | 0.689 |
FES |
0.734 | -0.152 | -1 | 0.745 |
ZAP70 |
0.734 | -0.010 | -1 | 0.725 |
CK1G2 |
0.728 | -0.003 | -3 | 0.491 |
CK1A |
0.725 | 0.011 | -3 | 0.442 |