Motif 1046 (n=138)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A5PL33 | KRBA1 | S101 | ochoa | Protein KRBA1 | None |
| E7EW31 | PROB1 | S260 | ochoa | Proline-rich basic protein 1 | None |
| O14579 | COPE | S45 | ochoa | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| O15061 | SYNM | S653 | ochoa | Synemin (Desmuslin) | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}. |
| O15234 | CASC3 | S363 | ochoa | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}. |
| O43164 | PJA2 | S282 | ochoa | E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2) | Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390). {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:33934390}. |
| O43314 | PPIP5K2 | S223 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114). {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653, ECO:0000269|PubMed:29590114}. |
| O60488 | ACSL4 | S674 | ochoa | Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 4) (LACS 4) | Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590). {ECO:0000250|UniProtKB:O35547, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. |
| O75376 | NCOR1 | S2120 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75533 | SF3B1 | S129 | ochoa | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250|UniProtKB:Q99NB9, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:33509932, ECO:0000269|PubMed:34822310}. |
| O95573 | ACSL3 | S683 | ochoa | Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). {ECO:0000250|UniProtKB:Q63151, ECO:0000269|PubMed:18003621, ECO:0000269|PubMed:22633490}. |
| O95685 | PPP1R3D | S78 | ochoa | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. |
| O95759 | TBC1D8 | S1054 | ochoa | TBC1 domain family member 8 (AD 3) (Vascular Rab-GAP/TBC-containing protein) | May act as a GTPase-activating protein for Rab family protein(s). |
| P11137 | MAP2 | S1353 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P14317 | HCLS1 | S275 | ochoa | Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75) | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| P16144 | ITGB4 | S1696 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P20749 | BCL3 | S41 | ochoa|psp | B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}. |
| P27708 | CAD | S1038 | ochoa | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate. {ECO:0000269|PubMed:24332717}. |
| P29317 | EPHA2 | S570 | ochoa | Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.; FUNCTION: Acts as a receptor for human cytomegalovirus (HCMV) to mediate viral entry and fusion in glioblastoma cells. {ECO:0000269|PubMed:37146061}. |
| P29590 | PML | S505 | ochoa|psp | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs (PubMed:11500381, PubMed:11575918, PubMed:18391071). Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration. {ECO:0000269|PubMed:11500381, ECO:0000269|PubMed:11575918, ECO:0000269|PubMed:18391071}.; FUNCTION: Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response (PubMed:20972456, PubMed:28250117). Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity (PubMed:20972456, PubMed:28250117). {ECO:0000269|PubMed:20972456, ECO:0000269|PubMed:28250117}. |
| P31274 | HOXC9 | S159 | ochoa | Homeobox protein Hox-C9 (Homeobox protein Hox-3B) | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| P35916 | FLT4 | S953 | ochoa | Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| P41229 | KDM5C | S301 | ochoa | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
| P41229 | KDM5C | S1359 | ochoa | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742, ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:28262558}. |
| P46013 | MKI67 | S3041 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P48681 | NES | S459 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P48681 | NES | S842 | ochoa | Nestin | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}. |
| P49321 | NASP | S344 | ochoa | Nuclear autoantigenic sperm protein (NASP) | Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:Q99MD9, ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 1]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}.; FUNCTION: [Isoform 2]: Stabilizes soluble histone H3-H4. {ECO:0000269|PubMed:22195965}. |
| P55265 | ADAR | S825 | ochoa|psp | Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269|PubMed:12618436, ECO:0000269|PubMed:15556947, ECO:0000269|PubMed:15858013, ECO:0000269|PubMed:16120648, ECO:0000269|PubMed:16475990, ECO:0000269|PubMed:17079286, ECO:0000269|PubMed:19605474, ECO:0000269|PubMed:19651874, ECO:0000269|PubMed:19710021, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159, ECO:0000269|PubMed:22278222, ECO:0000269|PubMed:7565688, ECO:0000269|PubMed:7972084}. |
| P57737 | CORO7 | S807 | ochoa | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
| Q01860 | POU5F1 | S111 | psp | POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}. |
| Q02040 | AKAP17A | S537 | ochoa | A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A) | Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. {ECO:0000269|PubMed:16982639, ECO:0000269|PubMed:19840947}. |
| Q08495 | DMTN | S383 | ochoa | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. |
| Q12888 | TP53BP1 | S294 | ochoa|psp | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S993 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q12888 | TP53BP1 | S1462 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13049 | TRIM32 | S328 | ochoa|psp | E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A) | E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy (PubMed:19349376, PubMed:31123703). Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1 (PubMed:22745133). Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages (PubMed:37543647). Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner (PubMed:28898289). Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions (PubMed:32918979). Ubiquitinates XIAP and targets it for proteasomal degradation (PubMed:21628460). Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation (PubMed:19349376). May ubiquitinate BBS2 (PubMed:22500027). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation (PubMed:31123703). Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL (PubMed:34888944). Under metabolic stress and phosphorylation by CHK2, mediates 'Lys-63'-linked ubiquitination of ATG7 at 'Lys-45' to initiate autophagy (PubMed:37943659). {ECO:0000250|UniProtKB:Q8CH72, ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:21628460, ECO:0000269|PubMed:22500027, ECO:0000269|PubMed:22745133, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:31123703, ECO:0000269|PubMed:32918979, ECO:0000269|PubMed:34888944, ECO:0000269|PubMed:37543647, ECO:0000269|PubMed:37943659}.; FUNCTION: (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo (PubMed:7778269). Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo (PubMed:7778269). {ECO:0000269|PubMed:7778269}. |
| Q13501 | SQSTM1 | S28 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13505 | MTX1 | S43 | ochoa | Metaxin-1 (Mitochondrial outer membrane import complex protein 1) | Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity). {ECO:0000250}. |
| Q14160 | SCRIB | S1475 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14676 | MDC1 | T1157 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1198 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1239 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1280 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1321 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1403 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1444 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1485 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1526 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1567 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1608 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14676 | MDC1 | T1649 | ochoa | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, PubMed:12607005, PubMed:12611903, PubMed:14695167, PubMed:15201865, PubMed:15377652, PubMed:16049003, PubMed:16377563, PubMed:30898438). Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:30898438). Also required for downstream events subsequent to the recruitment of these proteins (PubMed:12607005, PubMed:15201865, PubMed:16049003, PubMed:16377563, PubMed:18582474). These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis (PubMed:12499369, PubMed:12551934, PubMed:12607004). ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (PubMed:12499369, PubMed:12551934, PubMed:12607004). Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (PubMed:30898438). Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs (PubMed:18411307, PubMed:18582474, PubMed:18583988, PubMed:18678890). {ECO:0000269|PubMed:12475977, ECO:0000269|PubMed:12499369, ECO:0000269|PubMed:12551934, ECO:0000269|PubMed:12607003, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:12611903, ECO:0000269|PubMed:14695167, ECO:0000269|PubMed:15201865, ECO:0000269|PubMed:15377652, ECO:0000269|PubMed:16049003, ECO:0000269|PubMed:16377563, ECO:0000269|PubMed:18411307, ECO:0000269|PubMed:18582474, ECO:0000269|PubMed:18583988, ECO:0000269|PubMed:18678890, ECO:0000269|PubMed:30898438}. |
| Q14807 | KIF22 | S140 | ochoa | Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205). {ECO:0000250|UniProtKB:Q9I869, ECO:0000269|PubMed:25743205}. |
| Q15149 | PLEC | S149 | ochoa | Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}. |
| Q3L8U1 | CHD9 | S550 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q5SRE5 | NUP188 | S1729 | ochoa | Nucleoporin NUP188 (hNup188) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). {ECO:0000269|PubMed:32275884, ECO:0000305|PubMed:32275884}. |
| Q5T200 | ZC3H13 | S77 | ochoa | Zinc finger CCCH domain-containing protein 13 | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250|UniProtKB:E9Q784}. |
| Q5TAX3 | TUT4 | S296 | ochoa | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| Q5U5Q3 | MEX3C | S88 | ochoa | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}. |
| Q5VV52 | ZNF691 | S39 | ochoa | Zinc finger protein 691 | May be involved in transcriptional regulation. |
| Q5VZP5 | STYXL2 | S1054 | ochoa | Serine/threonine/tyrosine-interacting-like protein 2 (Inactive dual specificity phosphatase 27) | May be required for myofiber maturation. {ECO:0000250|UniProtKB:F1QWM2}. |
| Q6MZP7 | LIN54 | S635 | ochoa | Protein lin-54 homolog (CXC domain-containing protein 1) | Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17531812, PubMed:17671431). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17531812, PubMed:17671431). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17531812, PubMed:17671431). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). {ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:19725879, ECO:0000269|PubMed:27465258}. |
| Q6ZS81 | WDFY4 | S1847 | ochoa | WD repeat- and FYVE domain-containing protein 4 | Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy. {ECO:0000250|UniProtKB:E9Q2M9}. |
| Q6ZT07 | TBC1D9 | S471 | ochoa | TBC1 domain family member 9 (TBC1 domain family member 9A) | May act as a GTPase-activating protein for Rab family protein(s). |
| Q7Z2Z1 | TICRR | S292 | ochoa | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}. |
| Q7Z417 | NUFIP2 | S113 | ochoa | FMR1-interacting protein NUFIP2 (82 kDa FMRP-interacting protein) (82-FIP) (Cell proliferation-inducing gene 1 protein) (FMRP-interacting protein 2) (Nuclear FMR1-interacting protein 2) | Binds RNA. {ECO:0000269|PubMed:12837692}. |
| Q7Z5L9 | IRF2BP2 | S360 | ochoa|psp | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798). {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369, ECO:0000269|PubMed:27016798}. |
| Q7Z6E9 | RBBP6 | S861 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z6I6 | ARHGAP30 | S678 | ochoa | Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30) | GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269|PubMed:21565175}. |
| Q86VQ1 | GLCCI1 | S140 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86X51 | EZHIP | S105 | ochoa | EZH inhibitory protein | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}. |
| Q86X53 | ERICH1 | S254 | ochoa | Glutamate-rich protein 1 | None |
| Q8IW40 | DNAAF19 | S91 | ochoa | Dynein axonemal assembly factor 19 (Coiled-coil domain-containing protein 103) | Dynein-attachment factor required for cilia motility. {ECO:0000269|PubMed:22581229}. |
| Q8IWC1 | MAP7D3 | S441 | ochoa | MAP7 domain-containing protein 3 | Promotes the assembly and stability of microtubules. {ECO:0000269|PubMed:22142902, ECO:0000269|PubMed:24927501}. |
| Q8IYK8 | REM2 | S295 | ochoa | GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2) | Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis. {ECO:0000250|UniProtKB:Q9WTY2}. |
| Q8N0Z3 | SPICE1 | S477 | ochoa | Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein) | Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. {ECO:0000269|PubMed:20736305}. |
| Q8N103 | TAGAP | S354 | ochoa | T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein) | May function as a GTPase-activating protein and may play important roles during T-cell activation. {ECO:0000269|PubMed:15177553}. |
| Q8N196 | SIX5 | S283 | ochoa | Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5) | Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). {ECO:0000250}. |
| Q8N201 | INTS1 | S1395 | ochoa | Integrator complex subunit 1 (Int1) | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:25201415, PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144, PubMed:26308897, PubMed:30737432). Within the integrator complex, INTS1 is involved in the post-termination step: INTS1 displaces INTS3 and the SOSS factors, allowing the integrator complex to return to the closed conformation, ready to bind to the paused elongation complex for another termination cycle (PubMed:38570683). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:25201415, ECO:0000269|PubMed:26308897, ECO:0000269|PubMed:30737432, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}. |
| Q8N3J3 | HROB | S619 | ochoa | Homologous recombination OB-fold protein | DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. {ECO:0000269|PubMed:31467087}. |
| Q8N3K9 | CMYA5 | S2123 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N3Z3 | GTPBP8 | S74 | ochoa | GTP-binding protein 8 | None |
| Q8NEG4 | FAM83F | S61 | ochoa | Protein FAM83F | None |
| Q8NF50 | DOCK8 | S139 | ochoa | Dedicator of cytokinesis protein 8 | Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). {ECO:0000250|UniProtKB:Q8C147, ECO:0000269|PubMed:22461490, ECO:0000269|PubMed:25762780, ECO:0000269|PubMed:28028151}. |
| Q8TEH3 | DENND1A | S523 | ochoa | DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A) | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}. |
| Q8TEW8 | PARD3B | S338 | ochoa | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) | Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. |
| Q8TF72 | SHROOM3 | S910 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q92499 | DDX1 | S481 | ochoa | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) | Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (PubMed:24870230). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity). {ECO:0000250|UniProtKB:Q91VR5, ECO:0000269|PubMed:12183465, ECO:0000269|PubMed:15567440, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:18710941, ECO:0000269|PubMed:20573827, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs. {ECO:0000269|PubMed:15567440}.; FUNCTION: (Microbial infection) Required for Coronavirus IBV replication. {ECO:0000269|PubMed:20573827}. |
| Q92674 | CENPI | S284 | ochoa | Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269|PubMed:12640463, ECO:0000269|PubMed:16622420}. |
| Q96E14 | RMI2 | S112 | psp | RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000269|PubMed:18923082, ECO:0000269|PubMed:18923083, ECO:0000269|PubMed:27977684}. |
| Q96FZ2 | HMCES | T263 | ochoa | Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1) | Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235913, PubMed:31235915, PubMed:32307824, PubMed:32492421). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). Promotes error-free repair by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). The HMCES DNA-protein cross-link is then either reversed or degraded (PubMed:30554877, PubMed:36608669, PubMed:37519246, PubMed:37950866). HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites (PubMed:37519246, PubMed:37950866). The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase (PubMed:36608669). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Plays a protective role during somatic hypermutation of immunoglobulin genes in B-cells: acts via its ability to form covalent cross-links with abasic sites, thereby limiting the accumulation of deletions in somatic hypermutation target regions (PubMed:35450882). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). {ECO:0000250|UniProtKB:Q8R1M0, ECO:0000269|PubMed:30554877, ECO:0000269|PubMed:31235913, ECO:0000269|PubMed:31235915, ECO:0000269|PubMed:31806351, ECO:0000269|PubMed:32307824, ECO:0000269|PubMed:32492421, ECO:0000269|PubMed:35450882, ECO:0000269|PubMed:36608669, ECO:0000269|PubMed:37519246, ECO:0000269|PubMed:37950866}. |
| Q96HB5 | CCDC120 | S256 | ochoa | Coiled-coil domain-containing protein 120 | Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. {ECO:0000269|PubMed:25326380}. |
| Q96JM7 | L3MBTL3 | S678 | ochoa | Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) | Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q8BLB7, ECO:0000269|PubMed:29030483, ECO:0000269|PubMed:29691401, ECO:0000269|PubMed:30442713}. |
| Q96QC0 | PPP1R10 | S337 | ochoa | Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99) | Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (PubMed:39603239, PubMed:39603240). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (PubMed:39603239, PubMed:39603240). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (PubMed:31677974). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (PubMed:33264625). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (PubMed:30158517). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (PubMed:9450550). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates, such as RB (PubMed:18360108). {ECO:0000250|UniProtKB:Q80W00, ECO:0000269|PubMed:18360108, ECO:0000269|PubMed:30158517, ECO:0000269|PubMed:31677974, ECO:0000269|PubMed:33264625, ECO:0000269|PubMed:39603239, ECO:0000269|PubMed:39603240, ECO:0000269|PubMed:9450550}. |
| Q96T37 | RBM15 | S365 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q96TA1 | NIBAN2 | S638 | ochoa | Protein Niban 2 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Niban-like protein 1) (Protein FAM129B) | May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. {ECO:0000269|PubMed:19362540, ECO:0000269|PubMed:21148485}. |
| Q99576 | TSC22D3 | S102 | ochoa | TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:15031210). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7, ECO:0000269|PubMed:11468175, ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:15031210}.; FUNCTION: [Isoform 1]: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. {ECO:0000250|UniProtKB:Q9Z2S7}. |
| Q9BSJ8 | ESYT1 | S1034 | ochoa | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels (PubMed:23791178, PubMed:24183667). Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (PubMed:24183667). Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium (PubMed:38758649). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24183667, ECO:0000269|PubMed:38758649}. |
| Q9C0C2 | TNKS1BP1 | S672 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H1B7 | IRF2BPL | S69 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H1B7 | IRF2BPL | S547 | ochoa | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). {ECO:0000250|UniProtKB:Q5EIC4, ECO:0000269|PubMed:29374064, ECO:0000305|PubMed:17334524, ECO:0000305|PubMed:29374064, ECO:0000305|PubMed:30057031}. |
| Q9H6R4 | NOL6 | S289 | ochoa | Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap) | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:11895476, ECO:0000269|PubMed:34516797}. |
| Q9H6X5 | C19orf44 | S185 | ochoa | Uncharacterized protein C19orf44 | None |
| Q9H773 | DCTPP1 | S26 | ochoa | dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein) | Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. {ECO:0000269|PubMed:24467396}. |
| Q9H910 | JPT2 | S30 | ochoa | Jupiter microtubule associated homolog 2 (Hematological and neurological expressed 1-like protein) (HN1-like protein) | Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed:33758061, PubMed:33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed:33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062). {ECO:0000269|PubMed:33758061, ECO:0000269|PubMed:33758062}.; FUNCTION: (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2. {ECO:0000269|PubMed:33758061}. |
| Q9HCE9 | ANO8 | S669 | ochoa | Anoctamin-8 (Transmembrane protein 16H) | Does not exhibit calcium-activated chloride channel (CaCC) activity. |
| Q9NRA8 | EIF4ENIF1 | S587 | ochoa|psp | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}. |
| Q9NW13 | RBM28 | S397 | ochoa | RNA-binding protein 28 (RNA-binding motif protein 28) | Nucleolar component of the spliceosomal ribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
| Q9NY59 | SMPD3 | S238 | ochoa | Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). {ECO:0000250|UniProtKB:O35049, ECO:0000250|UniProtKB:Q9JJY3, ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}. |
| Q9NYJ7 | DLL3 | T532 | ochoa | Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3) | Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). {ECO:0000250}. |
| Q9P107 | GMIP | S234 | ochoa | GEM-interacting protein (GMIP) | Stimulates, in vitro and in vivo, the GTPase activity of RhoA. {ECO:0000269|PubMed:12093360}. |
| Q9P206 | NHSL3 | S929 | ochoa | NHS-like protein 3 | Able to directly activate the TNF-NFkappaB signaling pathway. {ECO:0000269|PubMed:32854746}. |
| Q9P266 | JCAD | S237 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9UDY2 | TJP2 | S966 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9UF56 | FBXL17 | S303 | ochoa | F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) | Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity). {ECO:0000250|UniProtKB:B1H1X1, ECO:0000250|UniProtKB:Q9QZN1, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:27234298, ECO:0000269|PubMed:30190310}. |
| Q9ULD5 | ZNF777 | S604 | ochoa | Zinc finger protein 777 | May be involved in transcriptional repression (PubMed:31856708). Inhibits cell proliferation through CDKN1A/p21 induction by down-regulation of NIBAN1/FAM129A at low cell density (PubMed:25560148). {ECO:0000269|PubMed:25560148, ECO:0000269|PubMed:31856708}. |
| Q9ULH0 | KIDINS220 | S1662 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULK2 | ATXN7L1 | S38 | ochoa | Ataxin-7-like protein 1 (Ataxin-7-like protein 4) | None |
| Q9UPN4 | CEP131 | S417 | ochoa | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Also acts as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:30804208}. |
| Q9UQ35 | SRRM2 | S1621 | ochoa | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:19854871, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30705154, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}. |
| Q9UQF2 | MAPK8IP1 | S341 | psp | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}. |
| Q9Y2F5 | ICE1 | S1854 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y490 | TLN1 | S1878 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y490 | TLN1 | S2162 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y4F5 | CEP170B | S853 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y5B0 | CTDP1 | S904 | ochoa | RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}. |
| Q9Y613 | FHOD1 | S486 | ochoa | FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1) | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. {ECO:0000269|PubMed:14576350, ECO:0000269|PubMed:15878344, ECO:0000269|PubMed:18694941}. |
| Q9Y678 | COPG1 | S633 | ochoa | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |
| Q9Y6J0 | CABIN1 | S1695 | ochoa | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. |
| P05187 | ALPP | S438 | Sugiyama | Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}. |
| P10696 | ALPG | S435 | Sugiyama | Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) | Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159}. |
| P31327 | CPS1 | S819 | Sugiyama | Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I) | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| P0DPH7 | TUBA3C | T292 | Sugiyama | Tubulin alpha-3C chain (EC 3.6.5.-) (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68363 | TUBA1B | T292 | Sugiyama | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:34996871, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:38305685, PubMed:34996871, PubMed:38609661). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). {ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661}. |
| P68366 | TUBA4A | T292 | Sugiyama | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q6PEY2 | TUBA3E | T292 | Sugiyama | Tubulin alpha-3E chain (EC 3.6.5.-) (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q71U36 | TUBA1A | T292 | Sugiyama | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q8IYS1 | PM20D2 | S27 | Sugiyama | Xaa-Arg dipeptidase (EC 3.4.13.4) (Beta-Ala-Lys dipeptidase) | Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. Postulated to function in a metabolite repair mechanism by eliminating alternate dipeptide by-products formed during carnosine synthesis. {ECO:0000269|PubMed:24891507}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.000003 | 5.516 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.000005 | 5.306 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.000002 | 5.784 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.000002 | 5.691 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.000005 | 5.297 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.000007 | 5.135 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.000010 | 5.015 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.000013 | 4.875 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.000020 | 4.700 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.000026 | 4.592 |
| R-HSA-983189 | Kinesins | 0.000032 | 4.501 |
| R-HSA-190861 | Gap junction assembly | 0.000032 | 4.489 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.000045 | 4.343 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.000049 | 4.307 |
| R-HSA-9646399 | Aggrephagy | 0.000062 | 4.211 |
| R-HSA-190828 | Gap junction trafficking | 0.000099 | 4.006 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.000133 | 3.875 |
| R-HSA-437239 | Recycling pathway of L1 | 0.000128 | 3.893 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.000129 | 3.891 |
| R-HSA-9833482 | PKR-mediated signaling | 0.000129 | 3.891 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.000151 | 3.822 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.000217 | 3.664 |
| R-HSA-9663891 | Selective autophagy | 0.000217 | 3.664 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.000205 | 3.688 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.000239 | 3.622 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.000385 | 3.414 |
| R-HSA-69275 | G2/M Transition | 0.000444 | 3.353 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.000473 | 3.325 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.000484 | 3.315 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.000558 | 3.254 |
| R-HSA-9609690 | HCMV Early Events | 0.000605 | 3.218 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.000624 | 3.205 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.000663 | 3.179 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.000690 | 3.161 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.000741 | 3.130 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.000794 | 3.100 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.001207 | 2.918 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.001300 | 2.886 |
| R-HSA-5620924 | Intraflagellar transport | 0.001500 | 2.824 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.001564 | 2.806 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.001578 | 2.802 |
| R-HSA-391251 | Protein folding | 0.002033 | 2.692 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.002131 | 2.671 |
| R-HSA-9609646 | HCMV Infection | 0.002527 | 2.597 |
| R-HSA-68877 | Mitotic Prometaphase | 0.002586 | 2.587 |
| R-HSA-434313 | Intracellular metabolism of fatty acids regulates insulin secretion | 0.002847 | 2.546 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.002925 | 2.534 |
| R-HSA-1632852 | Macroautophagy | 0.002643 | 2.578 |
| R-HSA-913531 | Interferon Signaling | 0.002802 | 2.553 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.003247 | 2.489 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.004206 | 2.376 |
| R-HSA-9612973 | Autophagy | 0.004218 | 2.375 |
| R-HSA-68882 | Mitotic Anaphase | 0.004627 | 2.335 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.004732 | 2.325 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.005226 | 2.282 |
| R-HSA-373760 | L1CAM interactions | 0.005650 | 2.248 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.006846 | 2.165 |
| R-HSA-452723 | Transcriptional regulation of pluripotent stem cells | 0.007205 | 2.142 |
| R-HSA-5617833 | Cilium Assembly | 0.009943 | 2.002 |
| R-HSA-1640170 | Cell Cycle | 0.010754 | 1.968 |
| R-HSA-75153 | Apoptotic execution phase | 0.011774 | 1.929 |
| R-HSA-9827857 | Specification of primordial germ cells | 0.015816 | 1.801 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.015877 | 1.799 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.016132 | 1.792 |
| R-HSA-77042 | Formation of editosomes by ADAR proteins | 0.017117 | 1.767 |
| R-HSA-9754189 | Germ layer formation at gastrulation | 0.018614 | 1.730 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 0.021603 | 1.665 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.021603 | 1.665 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.024094 | 1.618 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.024094 | 1.618 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.026780 | 1.572 |
| R-HSA-429947 | Deadenylation of mRNA | 0.028128 | 1.551 |
| R-HSA-68886 | M Phase | 0.024262 | 1.615 |
| R-HSA-400451 | Free fatty acids regulate insulin secretion | 0.026431 | 1.578 |
| R-HSA-3214842 | HDMs demethylate histones | 0.029868 | 1.525 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.031569 | 1.501 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.033644 | 1.473 |
| R-HSA-75064 | mRNA Editing: A to I Conversion | 0.033943 | 1.469 |
| R-HSA-75102 | C6 deamination of adenosine | 0.033943 | 1.469 |
| R-HSA-376172 | DSCAM interactions | 0.033943 | 1.469 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.034692 | 1.460 |
| R-HSA-380287 | Centrosome maturation | 0.035757 | 1.447 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.039179 | 1.407 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.042498 | 1.372 |
| R-HSA-5626978 | TNFR1-mediated ceramide production | 0.050482 | 1.297 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.046090 | 1.336 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.043173 | 1.365 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.046134 | 1.336 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.055035 | 1.259 |
| R-HSA-422475 | Axon guidance | 0.057511 | 1.240 |
| R-HSA-9758941 | Gastrulation | 0.057559 | 1.240 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.060537 | 1.218 |
| R-HSA-199991 | Membrane Trafficking | 0.065124 | 1.186 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.066741 | 1.176 |
| R-HSA-2892245 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | 0.082723 | 1.082 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.082723 | 1.082 |
| R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization | 0.066741 | 1.176 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.084940 | 1.071 |
| R-HSA-194313 | VEGF ligand-receptor interactions | 0.066741 | 1.176 |
| R-HSA-8948747 | Regulation of PTEN localization | 0.082723 | 1.082 |
| R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs | 0.072400 | 1.140 |
| R-HSA-9675108 | Nervous system development | 0.078393 | 1.106 |
| R-HSA-9824272 | Somitogenesis | 0.077339 | 1.112 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.077854 | 1.109 |
| R-HSA-2262752 | Cellular responses to stress | 0.065653 | 1.183 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.079010 | 1.102 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.090261 | 1.044 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 0.090612 | 1.043 |
| R-HSA-170984 | ARMS-mediated activation | 0.098434 | 1.007 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.136551 | 0.865 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.151346 | 0.820 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.158649 | 0.800 |
| R-HSA-2892247 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | 0.165889 | 0.780 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.173068 | 0.762 |
| R-HSA-167242 | Abortive elongation of HIV-1 transcript in the absence of Tat | 0.187241 | 0.728 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.187241 | 0.728 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.194237 | 0.712 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.194237 | 0.712 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.194237 | 0.712 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.194237 | 0.712 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.194237 | 0.712 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.208051 | 0.682 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.208051 | 0.682 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.234976 | 0.629 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.248096 | 0.605 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.248096 | 0.605 |
| R-HSA-113418 | Formation of the Early Elongation Complex | 0.254571 | 0.594 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.254571 | 0.594 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.254571 | 0.594 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.260992 | 0.583 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.267358 | 0.573 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.273669 | 0.563 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.273669 | 0.563 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.286129 | 0.543 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.286129 | 0.543 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.155257 | 0.809 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.182695 | 0.738 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.279442 | 0.554 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.258996 | 0.587 |
| R-HSA-140342 | Apoptosis induced DNA fragmentation | 0.106189 | 0.974 |
| R-HSA-354192 | Integrin signaling | 0.286129 | 0.543 |
| R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | 0.254571 | 0.594 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.248096 | 0.605 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.286129 | 0.543 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.286129 | 0.543 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.096387 | 1.016 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.114535 | 0.941 |
| R-HSA-1538133 | G0 and Early G1 | 0.279926 | 0.553 |
| R-HSA-5693538 | Homology Directed Repair | 0.106909 | 0.971 |
| R-HSA-209560 | NF-kB is activated and signals survival | 0.121500 | 0.915 |
| R-HSA-418890 | Role of second messengers in netrin-1 signaling | 0.129058 | 0.889 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.214869 | 0.668 |
| R-HSA-8949613 | Cristae formation | 0.248096 | 0.605 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.137461 | 0.862 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.184467 | 0.734 |
| R-HSA-193639 | p75NTR signals via NF-kB | 0.151346 | 0.820 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.198233 | 0.703 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 0.129058 | 0.889 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.264666 | 0.577 |
| R-HSA-500753 | Pyrimidine biosynthesis | 0.187241 | 0.728 |
| R-HSA-9620244 | Long-term potentiation | 0.234976 | 0.629 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.098434 | 1.007 |
| R-HSA-156711 | Polo-like kinase mediated events | 0.180185 | 0.744 |
| R-HSA-9707616 | Heme signaling | 0.123012 | 0.910 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.158649 | 0.800 |
| R-HSA-75072 | mRNA Editing | 0.098434 | 1.007 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.121500 | 0.915 |
| R-HSA-169893 | Prolonged ERK activation events | 0.158649 | 0.800 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.236075 | 0.627 |
| R-HSA-9664873 | Pexophagy | 0.106189 | 0.974 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 0.143980 | 0.842 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.123012 | 0.910 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.286129 | 0.543 |
| R-HSA-9834899 | Specification of the neural plate border | 0.187241 | 0.728 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.129058 | 0.889 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.208051 | 0.682 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.098079 | 1.008 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 0.234976 | 0.629 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 0.165889 | 0.780 |
| R-HSA-8953854 | Metabolism of RNA | 0.206024 | 0.686 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 0.286129 | 0.543 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.129058 | 0.889 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.129058 | 0.889 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.129058 | 0.889 |
| R-HSA-9733458 | Induction of Cell-Cell Fusion | 0.158649 | 0.800 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.241564 | 0.617 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.114535 | 0.941 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 0.254571 | 0.594 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.165889 | 0.780 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.176533 | 0.753 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.120170 | 0.920 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.180172 | 0.744 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 0.221629 | 0.654 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.116005 | 0.936 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.158649 | 0.800 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 0.158649 | 0.800 |
| R-HSA-70635 | Urea cycle | 0.241564 | 0.617 |
| R-HSA-69481 | G2/M Checkpoints | 0.125381 | 0.902 |
| R-HSA-1266738 | Developmental Biology | 0.179780 | 0.745 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.279926 | 0.553 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.220106 | 0.657 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.098434 | 1.007 |
| R-HSA-2028269 | Signaling by Hippo | 0.173068 | 0.762 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.158266 | 0.801 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.105141 | 0.978 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.261534 | 0.582 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.180428 | 0.744 |
| R-HSA-109581 | Apoptosis | 0.204115 | 0.690 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.105125 | 0.978 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.146302 | 0.835 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.214869 | 0.668 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.286129 | 0.543 |
| R-HSA-112316 | Neuronal System | 0.248297 | 0.605 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.151346 | 0.820 |
| R-HSA-3000170 | Syndecan interactions | 0.221629 | 0.654 |
| R-HSA-3000157 | Laminin interactions | 0.234976 | 0.629 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.179610 | 0.746 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.277468 | 0.557 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.241564 | 0.617 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.185788 | 0.731 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.114535 | 0.941 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.128802 | 0.890 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.286129 | 0.543 |
| R-HSA-422356 | Regulation of insulin secretion | 0.242430 | 0.615 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.198233 | 0.703 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.217077 | 0.663 |
| R-HSA-1474290 | Collagen formation | 0.226561 | 0.645 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.290203 | 0.537 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.292280 | 0.534 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.292280 | 0.534 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.292280 | 0.534 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 0.292280 | 0.534 |
| R-HSA-5223345 | Miscellaneous transport and binding events | 0.292280 | 0.534 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.296561 | 0.528 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.298378 | 0.525 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.298378 | 0.525 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.298378 | 0.525 |
| R-HSA-5205647 | Mitophagy | 0.298378 | 0.525 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.298378 | 0.525 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.304424 | 0.517 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.304424 | 0.517 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 0.304424 | 0.517 |
| R-HSA-187687 | Signalling to ERKs | 0.304424 | 0.517 |
| R-HSA-72172 | mRNA Splicing | 0.305214 | 0.515 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.306083 | 0.514 |
| R-HSA-5357801 | Programmed Cell Death | 0.307564 | 0.512 |
| R-HSA-9845576 | Glycosphingolipid transport | 0.310418 | 0.508 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.310418 | 0.508 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.316361 | 0.500 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.316361 | 0.500 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.322253 | 0.492 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.322253 | 0.492 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.325052 | 0.488 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.328094 | 0.484 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.328094 | 0.484 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.328094 | 0.484 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.328094 | 0.484 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.333886 | 0.476 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.333886 | 0.476 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.333886 | 0.476 |
| R-HSA-167169 | HIV Transcription Elongation | 0.333886 | 0.476 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.333886 | 0.476 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.333886 | 0.476 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.333886 | 0.476 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.339628 | 0.469 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.339628 | 0.469 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.345321 | 0.462 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.345321 | 0.462 |
| R-HSA-6811438 | Intra-Golgi traffic | 0.345321 | 0.462 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.346274 | 0.461 |
| R-HSA-114608 | Platelet degranulation | 0.347012 | 0.460 |
| R-HSA-1474165 | Reproduction | 0.359458 | 0.444 |
| R-HSA-373752 | Netrin-1 signaling | 0.362108 | 0.441 |
| R-HSA-9843745 | Adipogenesis | 0.362556 | 0.441 |
| R-HSA-9909396 | Circadian clock | 0.365649 | 0.437 |
| R-HSA-774815 | Nucleosome assembly | 0.367609 | 0.435 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.367609 | 0.435 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.367609 | 0.435 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.367609 | 0.435 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.367609 | 0.435 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.368737 | 0.433 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.373062 | 0.428 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.373062 | 0.428 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.373062 | 0.428 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.373062 | 0.428 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.373062 | 0.428 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.373062 | 0.428 |
| R-HSA-9675135 | Diseases of DNA repair | 0.373062 | 0.428 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.375684 | 0.425 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.378469 | 0.422 |
| R-HSA-163685 | Integration of energy metabolism | 0.381027 | 0.419 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.389143 | 0.410 |
| R-HSA-157118 | Signaling by NOTCH | 0.389668 | 0.409 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.390178 | 0.409 |
| R-HSA-109582 | Hemostasis | 0.393412 | 0.405 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.402288 | 0.395 |
| R-HSA-72187 | mRNA 3'-end processing | 0.404815 | 0.393 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.404815 | 0.393 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.409950 | 0.387 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.409950 | 0.387 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.409950 | 0.387 |
| R-HSA-4839726 | Chromatin organization | 0.410498 | 0.387 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.420088 | 0.377 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.425092 | 0.372 |
| R-HSA-75893 | TNF signaling | 0.425092 | 0.372 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.430052 | 0.366 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.430052 | 0.366 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.434971 | 0.362 |
| R-HSA-73887 | Death Receptor Signaling | 0.437913 | 0.359 |
| R-HSA-191859 | snRNP Assembly | 0.439847 | 0.357 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.439847 | 0.357 |
| R-HSA-1989781 | PPARA activates gene expression | 0.440831 | 0.356 |
| R-HSA-1280218 | Adaptive Immune System | 0.441187 | 0.355 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.444682 | 0.352 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.444682 | 0.352 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.444682 | 0.352 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.444682 | 0.352 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.444682 | 0.352 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.446642 | 0.350 |
| R-HSA-162587 | HIV Life Cycle | 0.446642 | 0.350 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.449475 | 0.347 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.449475 | 0.347 |
| R-HSA-877300 | Interferon gamma signaling | 0.452420 | 0.344 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.454227 | 0.343 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.454227 | 0.343 |
| R-HSA-1268020 | Mitochondrial protein import | 0.454227 | 0.343 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.455296 | 0.342 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.458938 | 0.338 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.458938 | 0.338 |
| R-HSA-373755 | Semaphorin interactions | 0.458938 | 0.338 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.461960 | 0.335 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.468240 | 0.330 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.477383 | 0.321 |
| R-HSA-167172 | Transcription of the HIV genome | 0.481896 | 0.317 |
| R-HSA-597592 | Post-translational protein modification | 0.485456 | 0.314 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.486353 | 0.313 |
| R-HSA-72306 | tRNA processing | 0.486353 | 0.313 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.490806 | 0.309 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.490806 | 0.309 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 0.490806 | 0.309 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.495204 | 0.305 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.499564 | 0.301 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.499564 | 0.301 |
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | 0.499564 | 0.301 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.503887 | 0.298 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.508172 | 0.294 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.508172 | 0.294 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.512421 | 0.290 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.512421 | 0.290 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.516633 | 0.287 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.520810 | 0.283 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.524950 | 0.280 |
| R-HSA-4086400 | PCP/CE pathway | 0.524950 | 0.280 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.529055 | 0.276 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.534751 | 0.272 |
| R-HSA-9824446 | Viral Infection Pathways | 0.534955 | 0.272 |
| R-HSA-983712 | Ion channel transport | 0.537347 | 0.270 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.552955 | 0.257 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.556820 | 0.254 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.556820 | 0.254 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.556820 | 0.254 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.560651 | 0.251 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.572656 | 0.242 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.579321 | 0.237 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.586566 | 0.232 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.586566 | 0.232 |
| R-HSA-397014 | Muscle contraction | 0.596666 | 0.224 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.607567 | 0.216 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.610962 | 0.214 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.614329 | 0.212 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.617666 | 0.209 |
| R-HSA-70171 | Glycolysis | 0.617666 | 0.209 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.620975 | 0.207 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.624256 | 0.205 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.627854 | 0.202 |
| R-HSA-162906 | HIV Infection | 0.630779 | 0.200 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.633929 | 0.198 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.633929 | 0.198 |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | 0.633929 | 0.198 |
| R-HSA-73894 | DNA Repair | 0.639663 | 0.194 |
| R-HSA-72312 | rRNA processing | 0.641644 | 0.193 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.643355 | 0.192 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.643355 | 0.192 |
| R-HSA-211000 | Gene Silencing by RNA | 0.643355 | 0.192 |
| R-HSA-162582 | Signal Transduction | 0.645928 | 0.190 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.646443 | 0.189 |
| R-HSA-15869 | Metabolism of nucleotides | 0.650156 | 0.187 |
| R-HSA-74160 | Gene expression (Transcription) | 0.657375 | 0.182 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.658532 | 0.181 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.658532 | 0.181 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.667329 | 0.176 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.678709 | 0.168 |
| R-HSA-70326 | Glucose metabolism | 0.678709 | 0.168 |
| R-HSA-68875 | Mitotic Prophase | 0.686989 | 0.163 |
| R-HSA-73886 | Chromosome Maintenance | 0.689702 | 0.161 |
| R-HSA-3371556 | Cellular response to heat stress | 0.689702 | 0.161 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 0.695058 | 0.158 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.697701 | 0.156 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.702920 | 0.153 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.702920 | 0.153 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.702920 | 0.153 |
| R-HSA-69206 | G1/S Transition | 0.702920 | 0.153 |
| R-HSA-194138 | Signaling by VEGF | 0.702920 | 0.153 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.710581 | 0.148 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.723207 | 0.141 |
| R-HSA-446728 | Cell junction organization | 0.730103 | 0.137 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.734728 | 0.134 |
| R-HSA-6807070 | PTEN Regulation | 0.741574 | 0.130 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.748324 | 0.126 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.750430 | 0.125 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.758985 | 0.120 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.759366 | 0.120 |
| R-HSA-166520 | Signaling by NTRKs | 0.763152 | 0.117 |
| R-HSA-69242 | S Phase | 0.763152 | 0.117 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.771274 | 0.113 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.771274 | 0.113 |
| R-HSA-9609507 | Protein localization | 0.773261 | 0.112 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.775230 | 0.111 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.777183 | 0.109 |
| R-HSA-9610379 | HCMV Late Events | 0.781038 | 0.107 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.786696 | 0.104 |
| R-HSA-1500931 | Cell-Cell communication | 0.788648 | 0.103 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.798137 | 0.098 |
| R-HSA-5619102 | SLC transporter disorders | 0.799342 | 0.097 |
| R-HSA-212436 | Generic Transcription Pathway | 0.808261 | 0.092 |
| R-HSA-1474244 | Extracellular matrix organization | 0.808522 | 0.092 |
| R-HSA-168255 | Influenza Infection | 0.820883 | 0.086 |
| R-HSA-2559583 | Cellular Senescence | 0.822442 | 0.085 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.827884 | 0.082 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.830178 | 0.081 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.844807 | 0.073 |
| R-HSA-428157 | Sphingolipid metabolism | 0.852233 | 0.069 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.854797 | 0.068 |
| R-HSA-8951664 | Neddylation | 0.877055 | 0.057 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.882327 | 0.054 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.884372 | 0.053 |
| R-HSA-8978868 | Fatty acid metabolism | 0.886597 | 0.052 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.902123 | 0.045 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.914239 | 0.039 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.914954 | 0.039 |
| R-HSA-5663205 | Infectious disease | 0.933632 | 0.030 |
| R-HSA-1483257 | Phospholipid metabolism | 0.935816 | 0.029 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.935816 | 0.029 |
| R-HSA-195721 | Signaling by WNT | 0.937489 | 0.028 |
| R-HSA-392499 | Metabolism of proteins | 0.942950 | 0.026 |
| R-HSA-8957322 | Metabolism of steroids | 0.950291 | 0.022 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.957592 | 0.019 |
| R-HSA-168256 | Immune System | 0.960879 | 0.017 |
| R-HSA-9679506 | SARS-CoV Infections | 0.961055 | 0.017 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.964774 | 0.016 |
| R-HSA-382551 | Transport of small molecules | 0.976122 | 0.010 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.984559 | 0.007 |
| R-HSA-6798695 | Neutrophil degranulation | 0.984832 | 0.007 |
| R-HSA-556833 | Metabolism of lipids | 0.991895 | 0.004 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.996405 | 0.002 |
| R-HSA-449147 | Signaling by Interleukins | 0.996624 | 0.001 |
| R-HSA-1643685 | Disease | 0.998113 | 0.001 |
| R-HSA-168249 | Innate Immune System | 0.999929 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
HIPK2 |
0.782 | 0.590 | 1 | 0.828 |
DYRK4 |
0.775 | 0.604 | 1 | 0.840 |
DYRK2 |
0.769 | 0.588 | 1 | 0.751 |
P38G |
0.769 | 0.599 | 1 | 0.878 |
KIS |
0.768 | 0.562 | 1 | 0.787 |
JNK2 |
0.766 | 0.604 | 1 | 0.849 |
HIPK1 |
0.765 | 0.549 | 1 | 0.731 |
CLK3 |
0.764 | 0.465 | 1 | 0.538 |
CDK19 |
0.764 | 0.574 | 1 | 0.839 |
P38D |
0.763 | 0.591 | 1 | 0.878 |
CDK8 |
0.763 | 0.578 | 1 | 0.811 |
DYRK1B |
0.763 | 0.576 | 1 | 0.794 |
P38B |
0.761 | 0.584 | 1 | 0.816 |
CDK17 |
0.761 | 0.582 | 1 | 0.872 |
CDK1 |
0.760 | 0.561 | 1 | 0.833 |
CDK3 |
0.760 | 0.506 | 1 | 0.869 |
CDK18 |
0.760 | 0.566 | 1 | 0.846 |
CDK10 |
0.760 | 0.557 | 1 | 0.823 |
HIPK4 |
0.759 | 0.417 | 1 | 0.563 |
JNK3 |
0.758 | 0.593 | 1 | 0.827 |
CLK2 |
0.757 | 0.406 | -3 | 0.811 |
CDK12 |
0.756 | 0.575 | 1 | 0.846 |
CDK13 |
0.756 | 0.574 | 1 | 0.830 |
SRPK1 |
0.756 | 0.351 | -3 | 0.822 |
ERK1 |
0.756 | 0.555 | 1 | 0.830 |
HIPK3 |
0.755 | 0.527 | 1 | 0.701 |
CDK7 |
0.754 | 0.560 | 1 | 0.817 |
CDK16 |
0.754 | 0.551 | 1 | 0.862 |
CDK5 |
0.753 | 0.532 | 1 | 0.790 |
P38A |
0.753 | 0.559 | 1 | 0.755 |
DYRK1A |
0.753 | 0.484 | 1 | 0.723 |
CDK9 |
0.750 | 0.563 | 1 | 0.819 |
SRPK2 |
0.749 | 0.316 | -3 | 0.770 |
FAM20C |
0.749 | 0.543 | 2 | 0.825 |
CDK14 |
0.749 | 0.553 | 1 | 0.808 |
DYRK3 |
0.748 | 0.461 | 1 | 0.694 |
CDK4 |
0.747 | 0.563 | 1 | 0.854 |
CLK1 |
0.745 | 0.366 | -3 | 0.814 |
CLK4 |
0.743 | 0.354 | -3 | 0.835 |
ERK2 |
0.743 | 0.549 | 1 | 0.782 |
JNK1 |
0.743 | 0.535 | 1 | 0.849 |
SRPK3 |
0.742 | 0.287 | -3 | 0.810 |
CDK6 |
0.741 | 0.529 | 1 | 0.824 |
NLK |
0.741 | 0.483 | 1 | 0.562 |
MAK |
0.735 | 0.395 | -2 | 0.749 |
ICK |
0.731 | 0.305 | -3 | 0.865 |
CDKL5 |
0.730 | 0.176 | -3 | 0.844 |
MOK |
0.729 | 0.386 | 1 | 0.619 |
CDK2 |
0.729 | 0.407 | 1 | 0.716 |
CDKL1 |
0.728 | 0.183 | -3 | 0.851 |
ERK5 |
0.725 | 0.243 | 1 | 0.479 |
ERK7 |
0.722 | 0.155 | 2 | 0.095 |
CAMK1B |
0.719 | 0.077 | -3 | 0.877 |
PRP4 |
0.718 | 0.316 | -3 | 0.690 |
RSK2 |
0.717 | 0.102 | -3 | 0.820 |
MTOR |
0.716 | 0.139 | 1 | 0.354 |
PIM1 |
0.714 | 0.114 | -3 | 0.821 |
P90RSK |
0.712 | 0.092 | -3 | 0.830 |
PRKD2 |
0.712 | 0.091 | -3 | 0.790 |
PRKD1 |
0.712 | 0.070 | -3 | 0.824 |
NUAK2 |
0.711 | 0.049 | -3 | 0.854 |
PKN3 |
0.710 | 0.016 | -3 | 0.840 |
MOS |
0.710 | -0.022 | 1 | 0.253 |
PRPK |
0.709 | -0.029 | -1 | 0.816 |
RSK3 |
0.709 | 0.083 | -3 | 0.818 |
PIM3 |
0.709 | 0.044 | -3 | 0.839 |
ATR |
0.708 | -0.011 | 1 | 0.237 |
CDC7 |
0.708 | -0.075 | 1 | 0.209 |
P70S6KB |
0.707 | 0.084 | -3 | 0.831 |
COT |
0.707 | -0.073 | 2 | 0.235 |
CAMLCK |
0.707 | 0.055 | -2 | 0.836 |
WNK1 |
0.707 | -0.019 | -2 | 0.847 |
PRKD3 |
0.706 | 0.077 | -3 | 0.812 |
RSK4 |
0.706 | 0.106 | -3 | 0.789 |
CAMK2G |
0.706 | 0.018 | 2 | 0.287 |
CAMK2B |
0.706 | 0.125 | 2 | 0.370 |
NIK |
0.705 | -0.014 | -3 | 0.857 |
CAMK2D |
0.704 | 0.075 | -3 | 0.835 |
TSSK2 |
0.704 | -0.013 | -5 | 0.743 |
DAPK2 |
0.704 | 0.025 | -3 | 0.869 |
MAPKAPK2 |
0.704 | 0.082 | -3 | 0.761 |
PIM2 |
0.704 | 0.121 | -3 | 0.809 |
BMPR2 |
0.704 | -0.064 | -2 | 0.873 |
PKCD |
0.702 | -0.019 | 2 | 0.155 |
PDHK4 |
0.702 | -0.001 | 1 | 0.250 |
NDR1 |
0.702 | 0.008 | -3 | 0.825 |
BMPR1B |
0.702 | 0.027 | 1 | 0.177 |
MAPKAPK3 |
0.702 | 0.037 | -3 | 0.792 |
TSSK1 |
0.701 | -0.011 | -3 | 0.843 |
AMPKA1 |
0.701 | -0.018 | -3 | 0.838 |
SKMLCK |
0.701 | 0.020 | -2 | 0.841 |
MARK4 |
0.700 | -0.005 | 4 | 0.805 |
NDR2 |
0.700 | 0.010 | -3 | 0.812 |
CAMK2A |
0.700 | 0.077 | 2 | 0.292 |
TBK1 |
0.700 | -0.115 | 1 | 0.157 |
MST4 |
0.700 | -0.044 | 2 | 0.190 |
AKT2 |
0.700 | 0.090 | -3 | 0.777 |
PKN2 |
0.699 | -0.040 | -3 | 0.835 |
LATS1 |
0.698 | 0.117 | -3 | 0.812 |
DSTYK |
0.698 | -0.056 | 2 | 0.282 |
AMPKA2 |
0.698 | 0.005 | -3 | 0.817 |
DNAPK |
0.697 | 0.053 | 1 | 0.212 |
PKACG |
0.697 | 0.037 | -2 | 0.738 |
GCN2 |
0.697 | -0.158 | 2 | 0.165 |
RAF1 |
0.696 | -0.159 | 1 | 0.188 |
TGFBR1 |
0.696 | 0.036 | -2 | 0.854 |
TGFBR2 |
0.696 | -0.055 | -2 | 0.844 |
SSTK |
0.695 | 0.010 | 4 | 0.815 |
BRSK1 |
0.695 | 0.014 | -3 | 0.817 |
HUNK |
0.695 | -0.139 | 2 | 0.180 |
SGK3 |
0.695 | 0.042 | -3 | 0.791 |
PDHK1 |
0.694 | -0.138 | 1 | 0.228 |
AURC |
0.694 | 0.029 | -2 | 0.674 |
ALK4 |
0.694 | -0.007 | -2 | 0.874 |
CHAK2 |
0.694 | -0.089 | -1 | 0.860 |
PKACB |
0.694 | 0.070 | -2 | 0.685 |
MSK1 |
0.693 | 0.071 | -3 | 0.798 |
PKCA |
0.693 | -0.033 | 2 | 0.131 |
LATS2 |
0.693 | 0.006 | -5 | 0.652 |
MSK2 |
0.693 | 0.050 | -3 | 0.809 |
ULK2 |
0.693 | -0.208 | 2 | 0.165 |
PAK1 |
0.693 | -0.015 | -2 | 0.770 |
IKKE |
0.693 | -0.132 | 1 | 0.156 |
IKKB |
0.692 | -0.098 | -2 | 0.709 |
NIM1 |
0.692 | -0.063 | 3 | 0.638 |
IRE1 |
0.692 | -0.114 | 1 | 0.177 |
GRK7 |
0.692 | -0.006 | 1 | 0.209 |
DCAMKL2 |
0.692 | -0.008 | -3 | 0.828 |
ATM |
0.692 | 0.001 | 1 | 0.202 |
CAMK1G |
0.691 | 0.021 | -3 | 0.824 |
GRK6 |
0.691 | -0.076 | 1 | 0.186 |
ALK2 |
0.691 | 0.051 | -2 | 0.852 |
QSK |
0.691 | -0.001 | 4 | 0.799 |
DCAMKL1 |
0.691 | 0.007 | -3 | 0.802 |
PKR |
0.691 | -0.076 | 1 | 0.202 |
PKCB |
0.691 | -0.047 | 2 | 0.137 |
PAK3 |
0.691 | -0.033 | -2 | 0.763 |
MYLK4 |
0.690 | 0.033 | -2 | 0.759 |
PAK6 |
0.689 | 0.001 | -2 | 0.691 |
GRK1 |
0.689 | -0.015 | -2 | 0.753 |
PKCG |
0.689 | -0.048 | 2 | 0.133 |
MNK2 |
0.689 | -0.015 | -2 | 0.782 |
BRSK2 |
0.689 | -0.033 | -3 | 0.822 |
PHKG1 |
0.689 | -0.049 | -3 | 0.825 |
PKCH |
0.689 | -0.055 | 2 | 0.131 |
MNK1 |
0.689 | -0.002 | -2 | 0.791 |
GRK5 |
0.689 | -0.136 | -3 | 0.814 |
CAMK4 |
0.689 | -0.053 | -3 | 0.827 |
SBK |
0.689 | 0.170 | -3 | 0.681 |
NEK6 |
0.689 | -0.140 | -2 | 0.847 |
PINK1 |
0.688 | 0.083 | 1 | 0.406 |
CAMK1D |
0.688 | 0.072 | -3 | 0.761 |
RIPK1 |
0.688 | -0.113 | 1 | 0.160 |
MPSK1 |
0.688 | 0.008 | 1 | 0.259 |
NUAK1 |
0.688 | -0.011 | -3 | 0.815 |
PKG2 |
0.688 | 0.021 | -2 | 0.689 |
QIK |
0.687 | -0.055 | -3 | 0.838 |
MEK1 |
0.687 | -0.116 | 2 | 0.209 |
ULK1 |
0.687 | -0.170 | -3 | 0.779 |
MLK1 |
0.687 | -0.186 | 2 | 0.183 |
WNK3 |
0.687 | -0.167 | 1 | 0.183 |
AKT1 |
0.687 | 0.060 | -3 | 0.771 |
DLK |
0.687 | -0.167 | 1 | 0.196 |
TTBK2 |
0.686 | -0.179 | 2 | 0.149 |
MARK3 |
0.686 | -0.003 | 4 | 0.752 |
SIK |
0.686 | 0.007 | -3 | 0.801 |
PRKX |
0.686 | 0.087 | -3 | 0.725 |
SGK1 |
0.686 | 0.108 | -3 | 0.708 |
MELK |
0.686 | -0.046 | -3 | 0.813 |
VRK2 |
0.686 | -0.093 | 1 | 0.282 |
MARK2 |
0.685 | -0.001 | 4 | 0.732 |
BMPR1A |
0.685 | 0.015 | 1 | 0.168 |
P70S6K |
0.685 | 0.076 | -3 | 0.779 |
PAK2 |
0.685 | -0.034 | -2 | 0.752 |
AURB |
0.685 | 0.006 | -2 | 0.668 |
ACVR2A |
0.684 | -0.032 | -2 | 0.833 |
NEK7 |
0.684 | -0.213 | -3 | 0.804 |
BUB1 |
0.684 | 0.053 | -5 | 0.738 |
PLK3 |
0.684 | -0.051 | 2 | 0.249 |
IRE2 |
0.684 | -0.105 | 2 | 0.136 |
MASTL |
0.684 | -0.182 | -2 | 0.773 |
PASK |
0.683 | 0.024 | -3 | 0.846 |
PKCZ |
0.683 | -0.069 | 2 | 0.145 |
MARK1 |
0.683 | -0.006 | 4 | 0.773 |
PKCE |
0.683 | 0.009 | 2 | 0.127 |
MLK3 |
0.683 | -0.125 | 2 | 0.153 |
CHK1 |
0.683 | -0.013 | -3 | 0.776 |
RIPK3 |
0.683 | -0.163 | 3 | 0.564 |
ACVR2B |
0.682 | -0.040 | -2 | 0.838 |
BCKDK |
0.682 | -0.110 | -1 | 0.739 |
ANKRD3 |
0.682 | -0.199 | 1 | 0.195 |
MAPKAPK5 |
0.682 | 0.026 | -3 | 0.787 |
SMG1 |
0.682 | -0.060 | 1 | 0.218 |
WNK4 |
0.682 | -0.083 | -2 | 0.836 |
PKCI |
0.681 | -0.022 | 2 | 0.133 |
AKT3 |
0.681 | 0.081 | -3 | 0.722 |
TLK1 |
0.681 | -0.084 | -2 | 0.837 |
MLK2 |
0.681 | -0.191 | 2 | 0.177 |
SMMLCK |
0.680 | 0.027 | -3 | 0.852 |
PKCT |
0.680 | -0.041 | 2 | 0.130 |
TLK2 |
0.680 | -0.110 | 1 | 0.192 |
PHKG2 |
0.680 | -0.041 | -3 | 0.818 |
PKACA |
0.680 | 0.059 | -2 | 0.645 |
CRIK |
0.680 | 0.134 | -3 | 0.763 |
NEK9 |
0.680 | -0.236 | 2 | 0.169 |
NEK2 |
0.679 | -0.164 | 2 | 0.151 |
PLK4 |
0.679 | -0.142 | 2 | 0.119 |
PLK1 |
0.679 | -0.128 | -2 | 0.806 |
AURA |
0.679 | 0.008 | -2 | 0.641 |
MRCKB |
0.679 | 0.058 | -3 | 0.789 |
GRK4 |
0.678 | -0.130 | -2 | 0.801 |
GSK3A |
0.678 | 0.107 | 4 | 0.304 |
PERK |
0.678 | -0.140 | -2 | 0.845 |
IKKA |
0.678 | -0.085 | -2 | 0.699 |
CAMK1A |
0.678 | 0.052 | -3 | 0.736 |
DAPK3 |
0.677 | 0.042 | -3 | 0.832 |
CHAK1 |
0.676 | -0.180 | 2 | 0.131 |
GRK2 |
0.676 | -0.060 | -2 | 0.703 |
YSK4 |
0.676 | -0.183 | 1 | 0.165 |
CHK2 |
0.676 | 0.045 | -3 | 0.734 |
SNRK |
0.676 | -0.124 | 2 | 0.115 |
MEK5 |
0.676 | -0.175 | 2 | 0.181 |
PKN1 |
0.676 | -0.000 | -3 | 0.793 |
GAK |
0.676 | -0.031 | 1 | 0.236 |
MLK4 |
0.675 | -0.152 | 2 | 0.157 |
ROCK2 |
0.675 | 0.054 | -3 | 0.806 |
MST3 |
0.675 | -0.102 | 2 | 0.158 |
CK1E |
0.674 | -0.004 | -3 | 0.612 |
DMPK1 |
0.674 | 0.084 | -3 | 0.803 |
DRAK1 |
0.674 | -0.132 | 1 | 0.148 |
PDK1 |
0.673 | -0.057 | 1 | 0.213 |
DAPK1 |
0.673 | 0.035 | -3 | 0.833 |
TAO3 |
0.673 | -0.082 | 1 | 0.209 |
BRAF |
0.673 | -0.107 | -4 | 0.745 |
CK1D |
0.672 | 0.029 | -3 | 0.566 |
MEKK2 |
0.672 | -0.171 | 2 | 0.169 |
MRCKA |
0.671 | 0.043 | -3 | 0.794 |
PBK |
0.671 | -0.009 | 1 | 0.214 |
HRI |
0.671 | -0.164 | -2 | 0.849 |
TTBK1 |
0.671 | -0.146 | 2 | 0.122 |
MEKK3 |
0.671 | -0.176 | 1 | 0.180 |
IRAK4 |
0.670 | -0.161 | 1 | 0.152 |
TAO2 |
0.669 | -0.087 | 2 | 0.186 |
YANK3 |
0.669 | -0.034 | 2 | 0.092 |
ZAK |
0.669 | -0.191 | 1 | 0.170 |
HASPIN |
0.669 | 0.015 | -1 | 0.740 |
CK2A2 |
0.668 | -0.014 | 1 | 0.166 |
LKB1 |
0.668 | -0.072 | -3 | 0.781 |
MEKK6 |
0.668 | -0.126 | 1 | 0.189 |
NEK5 |
0.668 | -0.197 | 1 | 0.177 |
CK1A2 |
0.667 | 0.003 | -3 | 0.575 |
PAK5 |
0.667 | -0.024 | -2 | 0.627 |
NEK11 |
0.667 | -0.163 | 1 | 0.202 |
TNIK |
0.667 | -0.062 | 3 | 0.765 |
LRRK2 |
0.666 | -0.060 | 2 | 0.179 |
MEKK1 |
0.666 | -0.210 | 1 | 0.189 |
KHS2 |
0.666 | -0.020 | 1 | 0.196 |
MAP3K15 |
0.666 | -0.135 | 1 | 0.179 |
HPK1 |
0.666 | -0.060 | 1 | 0.187 |
GCK |
0.665 | -0.082 | 1 | 0.196 |
PAK4 |
0.665 | -0.019 | -2 | 0.638 |
HGK |
0.664 | -0.088 | 3 | 0.753 |
STK33 |
0.664 | -0.106 | 2 | 0.114 |
GSK3B |
0.664 | 0.003 | 4 | 0.298 |
LOK |
0.664 | -0.080 | -2 | 0.737 |
NEK8 |
0.664 | -0.193 | 2 | 0.155 |
ROCK1 |
0.664 | 0.046 | -3 | 0.792 |
BIKE |
0.663 | -0.002 | 1 | 0.216 |
AAK1 |
0.663 | 0.024 | 1 | 0.214 |
EEF2K |
0.663 | -0.120 | 3 | 0.736 |
PLK2 |
0.662 | -0.038 | -3 | 0.751 |
KHS1 |
0.662 | -0.059 | 1 | 0.182 |
CK1G1 |
0.662 | -0.037 | -3 | 0.605 |
GRK3 |
0.661 | -0.064 | -2 | 0.665 |
NEK4 |
0.661 | -0.170 | 1 | 0.159 |
MINK |
0.660 | -0.110 | 1 | 0.167 |
CK2A1 |
0.660 | -0.021 | 1 | 0.154 |
SLK |
0.659 | -0.072 | -2 | 0.682 |
CAMKK2 |
0.658 | -0.131 | -2 | 0.719 |
IRAK1 |
0.658 | -0.150 | -1 | 0.721 |
CAMKK1 |
0.658 | -0.178 | -2 | 0.714 |
NEK1 |
0.656 | -0.175 | 1 | 0.153 |
TAK1 |
0.656 | -0.183 | 1 | 0.197 |
PKG1 |
0.655 | 0.007 | -2 | 0.629 |
YSK1 |
0.654 | -0.148 | 2 | 0.151 |
NEK3 |
0.652 | -0.120 | 1 | 0.176 |
MST2 |
0.652 | -0.181 | 1 | 0.178 |
MEK2 |
0.651 | -0.199 | 2 | 0.178 |
MST1 |
0.650 | -0.168 | 1 | 0.164 |
VRK1 |
0.649 | -0.232 | 2 | 0.173 |
ASK1 |
0.646 | -0.134 | 1 | 0.179 |
ALPHAK3 |
0.646 | 0.000 | -1 | 0.714 |
RIPK2 |
0.646 | -0.193 | 1 | 0.152 |
OSR1 |
0.643 | -0.132 | 2 | 0.153 |
TAO1 |
0.643 | -0.112 | 1 | 0.171 |
TTK |
0.641 | -0.120 | -2 | 0.833 |
MYO3B |
0.641 | -0.121 | 2 | 0.159 |
YANK2 |
0.637 | -0.046 | 2 | 0.119 |
MYO3A |
0.634 | -0.145 | 1 | 0.178 |
CK1A |
0.626 | -0.029 | -3 | 0.486 |
PDHK3_TYR |
0.625 | 0.080 | 4 | 0.823 |
STLK3 |
0.623 | -0.216 | 1 | 0.155 |
TESK1_TYR |
0.622 | 0.051 | 3 | 0.769 |
LIMK2_TYR |
0.621 | 0.080 | -3 | 0.825 |
CK1G3 |
0.621 | -0.016 | -3 | 0.444 |
PKMYT1_TYR |
0.618 | 0.064 | 3 | 0.725 |
MAP2K6_TYR |
0.617 | 0.065 | -1 | 0.817 |
MAP2K4_TYR |
0.617 | 0.025 | -1 | 0.825 |
PDHK4_TYR |
0.616 | 0.038 | 2 | 0.231 |
MAP2K7_TYR |
0.615 | -0.060 | 2 | 0.218 |
PINK1_TYR |
0.613 | -0.074 | 1 | 0.241 |
BMPR2_TYR |
0.612 | 0.033 | -1 | 0.800 |
LIMK1_TYR |
0.611 | -0.020 | 2 | 0.206 |
PDHK1_TYR |
0.611 | -0.032 | -1 | 0.822 |
EPHA6 |
0.609 | -0.039 | -1 | 0.777 |
RET |
0.607 | -0.085 | 1 | 0.198 |
FGFR2 |
0.603 | 0.009 | 3 | 0.644 |
DDR1 |
0.602 | -0.042 | 4 | 0.797 |
EPHA4 |
0.602 | -0.020 | 2 | 0.256 |
MST1R |
0.602 | -0.114 | 3 | 0.670 |
ABL2 |
0.601 | -0.036 | -1 | 0.744 |
NEK10_TYR |
0.600 | -0.101 | 1 | 0.181 |
JAK2 |
0.599 | -0.137 | 1 | 0.208 |
CK1G2 |
0.598 | -0.024 | -3 | 0.528 |
ABL1 |
0.598 | -0.057 | -1 | 0.744 |
TNK1 |
0.598 | -0.085 | 3 | 0.637 |
TNNI3K_TYR |
0.597 | -0.095 | 1 | 0.220 |
TYRO3 |
0.597 | -0.156 | 3 | 0.648 |
TYK2 |
0.597 | -0.213 | 1 | 0.188 |
EPHB4 |
0.597 | -0.102 | -1 | 0.742 |
YES1 |
0.597 | -0.065 | -1 | 0.801 |
CSF1R |
0.596 | -0.112 | 3 | 0.637 |
TXK |
0.596 | -0.074 | 1 | 0.173 |
FGR |
0.595 | -0.123 | 1 | 0.177 |
FGFR1 |
0.595 | -0.045 | 3 | 0.603 |
ROS1 |
0.594 | -0.189 | 3 | 0.599 |
FLT3 |
0.594 | -0.111 | 3 | 0.657 |
TEK |
0.594 | -0.028 | 3 | 0.560 |
FER |
0.593 | -0.120 | 1 | 0.196 |
INSRR |
0.591 | -0.075 | 3 | 0.576 |
SRMS |
0.591 | -0.084 | 1 | 0.167 |
JAK3 |
0.590 | -0.141 | 1 | 0.193 |
FGFR3 |
0.590 | -0.031 | 3 | 0.610 |
KIT |
0.589 | -0.103 | 3 | 0.641 |
HCK |
0.588 | -0.116 | -1 | 0.759 |
PTK2B |
0.588 | -0.052 | -1 | 0.732 |
KDR |
0.588 | -0.117 | 3 | 0.603 |
LCK |
0.588 | -0.090 | -1 | 0.759 |
PDGFRB |
0.588 | -0.169 | 3 | 0.650 |
TNK2 |
0.588 | -0.130 | 3 | 0.581 |
FYN |
0.588 | -0.038 | -1 | 0.747 |
MERTK |
0.587 | -0.124 | 3 | 0.628 |
EGFR |
0.587 | -0.044 | 1 | 0.144 |
ITK |
0.587 | -0.134 | -1 | 0.726 |
BLK |
0.586 | -0.085 | -1 | 0.769 |
PTK2 |
0.586 | -0.023 | -1 | 0.701 |
DDR2 |
0.586 | 0.001 | 3 | 0.560 |
JAK1 |
0.586 | -0.166 | 1 | 0.170 |
EPHB2 |
0.586 | -0.104 | -1 | 0.710 |
EPHA3 |
0.586 | -0.085 | 2 | 0.228 |
WEE1_TYR |
0.585 | -0.106 | -1 | 0.696 |
EPHA7 |
0.585 | -0.081 | 2 | 0.240 |
EPHB3 |
0.585 | -0.124 | -1 | 0.722 |
AXL |
0.585 | -0.142 | 3 | 0.606 |
EPHB1 |
0.585 | -0.152 | 1 | 0.168 |
ERBB2 |
0.584 | -0.113 | 1 | 0.172 |
MET |
0.583 | -0.112 | 3 | 0.641 |
PDGFRA |
0.583 | -0.203 | 3 | 0.647 |
LTK |
0.582 | -0.133 | 3 | 0.592 |
TEC |
0.581 | -0.124 | -1 | 0.693 |
EPHA1 |
0.581 | -0.115 | 3 | 0.619 |
ALK |
0.581 | -0.154 | 3 | 0.560 |
BTK |
0.581 | -0.156 | -1 | 0.703 |
BMX |
0.581 | -0.102 | -1 | 0.649 |
FGFR4 |
0.580 | -0.046 | -1 | 0.675 |
EPHA5 |
0.580 | -0.055 | 2 | 0.270 |
FLT1 |
0.579 | -0.125 | -1 | 0.726 |
FRK |
0.579 | -0.151 | -1 | 0.761 |
EPHA8 |
0.578 | -0.073 | -1 | 0.705 |
PTK6 |
0.578 | -0.201 | -1 | 0.666 |
LYN |
0.577 | -0.088 | 3 | 0.567 |
FLT4 |
0.577 | -0.146 | 3 | 0.590 |
INSR |
0.576 | -0.120 | 3 | 0.552 |
NTRK1 |
0.576 | -0.155 | -1 | 0.728 |
SYK |
0.575 | -0.039 | -1 | 0.668 |
SRC |
0.575 | -0.090 | -1 | 0.754 |
ERBB4 |
0.575 | -0.043 | 1 | 0.149 |
CSK |
0.574 | -0.111 | 2 | 0.224 |
MATK |
0.573 | -0.101 | -1 | 0.671 |
NTRK2 |
0.569 | -0.202 | 3 | 0.587 |
NTRK3 |
0.569 | -0.136 | -1 | 0.676 |
EPHA2 |
0.569 | -0.073 | -1 | 0.654 |
IGF1R |
0.567 | -0.098 | 3 | 0.500 |
MUSK |
0.563 | -0.158 | 1 | 0.123 |
ZAP70 |
0.562 | -0.038 | -1 | 0.609 |
FES |
0.549 | -0.141 | -1 | 0.638 |