Motif 1045 (n=155)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0C4DFX4 | None | T2707 | ochoa | Snf2 related CREBBP activator protein | None |
| A5YM69 | ARHGEF35 | T193 | ochoa | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | None |
| A8MTJ3 | GNAT3 | T48 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction (PubMed:38600377, PubMed:38776963). Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs such as TAS2R14 act as bitter sensors (PubMed:38600377, PubMed:38776963). Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330, ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}. |
| O00487 | PSMD14 | T266 | ochoa | 26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22909820, ECO:0000269|PubMed:9374539}. |
| O00592 | PODXL | T502 | ochoa | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) | Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}. |
| O15446 | POLR1G | T421 | ochoa | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) | Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. {ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.; FUNCTION: [Isoform 2]: Has been described as a component of preformed T-cell receptor (TCR) complex. {ECO:0000269|PubMed:10373416}. |
| O15551 | CLDN3 | T192 | psp | Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE-R 2) (CPE-receptor 2) (Rat ventral prostate.1 protein homolog) (hRVP1) | Barrier-forming claudin. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000269|PubMed:36008380}. |
| O43390 | HNRNPR | T21 | ochoa | Heterogeneous nuclear ribonucleoprotein R (hnRNP R) | Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. |
| O43707 | ACTN4 | T445 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O60306 | AQR | T771 | ochoa | RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28076346, PubMed:28502770). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:16949364, ECO:0000269|PubMed:25599396, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| O60566 | BUB1B | T284 | ochoa | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| O75052 | NOS1AP | T212 | ochoa | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000250|UniProtKB:O54960, ECO:0000269|PubMed:33523862}. |
| O75121 | MFAP3L | T361 | ochoa | Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9) | May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. {ECO:0000269|PubMed:24735981}. |
| O75554 | WBP4 | T324 | ochoa | WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4) | Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:19592703, PubMed:28781166, PubMed:9724750). May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (PubMed:9724750). {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9724750}. |
| O95602 | POLR1A | T360 | ochoa | DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) | Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity) (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). {ECO:0000250|UniProtKB:P10964, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}. |
| O95684 | CEP43 | T144 | ochoa | Centrosomal protein 43 (FGFR1 oncogene partner) | Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385). {ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:28659385}. |
| P00558 | PGK1 | T329 | ochoa | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959). {ECO:0000269|PubMed:18463139, ECO:0000269|PubMed:2324090, ECO:0000269|PubMed:26677959, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:30323285, ECO:0000269|PubMed:36849569, ECO:0000269|PubMed:7391028}. |
| P02679 | FGG | T400 | ochoa | Fibrinogen gamma chain | Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P04792 | HSPB1 | T184 | ochoa | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27) | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:20178975, ECO:0000269|PubMed:23728742}. |
| P04899 | GNAI2 | T48 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}. |
| P05062 | ALDOB | T281 | ochoa | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041). {ECO:0000269|PubMed:10970798, ECO:0000269|PubMed:12205126, ECO:0000269|PubMed:20848650, ECO:0000269|PubMed:35122041}. |
| P08047 | SP1 | T737 | psp | Transcription factor Sp1 | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity). {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}. |
| P08754 | GNAI3 | T48 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| P09471 | GNAO1 | T48 | ochoa | Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951, PubMed:33408414). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). {ECO:0000250|UniProtKB:P18872, ECO:0000269|PubMed:29925951, ECO:0000269|PubMed:33408414}. |
| P0CG47 | UBB | T22 | ochoa | Polyubiquitin-B [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}. |
| P0CG48 | UBC | T22 | ochoa | Polyubiquitin-C [Cleaved into: Ubiquitin] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (PubMed:38326650). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056). {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39548056, ECO:0000303|PubMed:19754430}. |
| P0DJD0 | RGPD1 | T1210 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T1218 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10966 | CD8B | T141 | ochoa | T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b) | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. {ECO:0000250|UniProtKB:P10300, ECO:0000269|PubMed:10925291, ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:17145893}. |
| P11488 | GNAT1 | T44 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000269|PubMed:22190596}. |
| P12270 | TPR | T1839 | ochoa | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. |
| P12814 | ACTN1 | T426 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P13667 | PDIA4 | T156 | ochoa | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
| P18583 | SON | T1549 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P19087 | GNAT2 | T48 | ochoa | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. |
| P21333 | FLNA | T2381 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P24593 | IGFBP5 | T124 | ochoa | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18930415, PubMed:7683690). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs (PubMed:20345844, PubMed:26103640). Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000250|UniProtKB:Q07079, ECO:0000269|PubMed:18930415, ECO:0000269|PubMed:20345844, ECO:0000269|PubMed:26103640, ECO:0000269|PubMed:36949068, ECO:0000269|PubMed:7683690}. |
| P36956 | SREBF1 | T426 | ochoa|psp | Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)] | [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:32322062}.; FUNCTION: [Processed sterol regulatory element-binding protein 1]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:12177166, PubMed:32322062, PubMed:8402897). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:12177166, PubMed:8402897). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:12177166, PubMed:32322062, PubMed:8402897). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:8402897}.; FUNCTION: [Isoform SREBP-1A]: Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:12177166, PubMed:32497488). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (By similarity). Required for innate immune response in macrophages by regulating lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32497488}.; FUNCTION: [Isoform SREBP-1C]: Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (PubMed:12177166). Strongly activates global lipid synthesis in rapidly growing cells (By similarity). {ECO:0000250|UniProtKB:Q9WTN3, ECO:0000269|PubMed:12177166}.; FUNCTION: [Isoform SREBP-1aDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}.; FUNCTION: [Isoform SREBP-1cDelta]: The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters. {ECO:0000305|PubMed:7759101}. |
| P40926 | MDH2 | T73 | ochoa | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | None |
| P46013 | MKI67 | T1120 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1485 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1606 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1972 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2212 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2333 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46821 | MAP1B | T2049 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49757 | NUMB | T304 | ochoa | Protein numb homolog (h-Numb) (Protein S171) | Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}. |
| P49792 | RANBP2 | T1156 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | T2201 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P62979 | RPS27A | T22 | ochoa | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome (PubMed:23636399, PubMed:9582194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:23636399, PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797, ECO:0000305|PubMed:9582194}. |
| P62987 | UBA52 | T22 | ochoa | Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40) (rpL40)] | [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:34239127, ECO:0000303|PubMed:19754430}.; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs (PubMed:23169626, PubMed:23636399, PubMed:32669547, PubMed:39048817, PubMed:39103523). {ECO:0000269|PubMed:23169626, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547, ECO:0000269|PubMed:39048817, ECO:0000269|PubMed:39103523}. |
| P63096 | GNAI1 | T48 | ochoa | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P78347 | GTF2I | T556 | ochoa | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. {ECO:0000269|PubMed:10373551, ECO:0000269|PubMed:11373296, ECO:0000269|PubMed:16738337}. |
| P78559 | MAP1A | T571 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P78559 | MAP1A | T1789 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P83916 | CBX1 | T51 | psp | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000250|UniProtKB:P83917}. |
| Q01826 | SATB1 | T188 | psp | DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1) | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. |
| Q05519 | SRSF11 | T452 | ochoa | Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11) | May function in pre-mRNA splicing. |
| Q0VF96 | CGNL1 | T252 | ochoa | Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin) | May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}. |
| Q12774 | ARHGEF5 | T193 | ochoa | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250|UniProtKB:E9Q7D5, ECO:0000269|PubMed:14662653, ECO:0000269|PubMed:15601624}. |
| Q12888 | TP53BP1 | T855 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13112 | CHAF1B | T397 | ochoa | Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) | Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}. |
| Q13501 | SQSTM1 | T350 | ochoa|psp | Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62) | Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (PubMed:16286508, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:34893540, PubMed:37802024). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (PubMed:15911346, PubMed:20168092, PubMed:22017874, PubMed:24128730, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:37802024). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:37802024). SQSTM1 is itself degraded along with its ubiquitinated cargos (PubMed:16286508, PubMed:17580304, PubMed:37802024). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (PubMed:26344566). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215, PubMed:37306101). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (PubMed:25101860). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 (PubMed:10356400, PubMed:10747026, PubMed:11244088, PubMed:12471037, PubMed:16079148, PubMed:19931284). May play a role in titin/TTN downstream signaling in muscle cells (PubMed:15802564). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). {ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22017874, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:25101860, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29343546, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:29507397, ECO:0000269|PubMed:31857589, ECO:0000269|PubMed:33393215, ECO:0000269|PubMed:33472082, ECO:0000269|PubMed:33509017, ECO:0000269|PubMed:34471133, ECO:0000269|PubMed:34893540, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:37306101, ECO:0000269|PubMed:37802024}. |
| Q13555 | CAMK2G | T368 | ochoa | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Q14126 | DSG2 | T650 | ochoa | Desmoglein-2 (Cadherin family member 5) (HDGC) | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). {ECO:0000250|UniProtKB:O55111, ECO:0000269|PubMed:27338829, ECO:0000269|PubMed:29910125, ECO:0000269|PubMed:38395410}. |
| Q14162 | SCARF1 | T689 | ochoa | Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) | Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity). {ECO:0000250}. |
| Q15046 | KARS1 | T52 | psp | Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216). {ECO:0000269|PubMed:14975237, ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:28887846, ECO:0000269|PubMed:5338216, ECO:0000269|PubMed:9278442}.; FUNCTION: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15220430}. |
| Q15326 | ZMYND11 | T415 | ochoa | Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69) | Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250|UniProtKB:Q8R5C8, ECO:0000269|PubMed:10734313, ECO:0000269|PubMed:16565076, ECO:0000269|PubMed:24675531}.; FUNCTION: (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. {ECO:0000269|PubMed:26845565}. |
| Q15527 | SURF2 | T190 | ochoa | Surfeit locus protein 2 (Surf-2) | None |
| Q15722 | LTB4R | T315 | ochoa|psp | Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Q16584 | MAP3K11 | T277 | psp | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Q16799 | RTN1 | T296 | ochoa | Reticulon-1 (Neuroendocrine-specific protein) | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}. |
| Q2NKX8 | ERCC6L | T740 | ochoa | DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15) | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}. |
| Q4G0J3 | LARP7 | T440 | psp | La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S) | RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18281698, PubMed:18483487). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q05CL8, ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18281698, ECO:0000269|PubMed:18483487, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:32017898}. |
| Q4G0N4 | NADK2 | T357 | psp | NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial) | Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo. {ECO:0000269|PubMed:23212377}. |
| Q587J8 | KHDC3L | T156 | psp | KH domain-containing protein 3 (ES cell-associated transcript 1 protein) (KHDC3-like protein) | Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (By similarity). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (By similarity). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (By similarity). KHDC3 ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process (By similarity). Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity). As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation (PubMed:31609975). Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific (By similarity). Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks (By similarity). Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus (By similarity). May regulate normal development of learning, memory and anxiety (By similarity). Capable of binding RNA (By similarity). {ECO:0000250|UniProtKB:Q9CWU5, ECO:0000269|PubMed:31609975}. |
| Q5C9Z4 | NOM1 | T56 | ochoa | Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) | Plays a role in targeting PPP1CA to the nucleolus. {ECO:0000269|PubMed:17965019}. |
| Q5JWF2 | GNAS | T698 | ochoa | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas) | Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. {ECO:0000250|UniProtKB:Q6R0H7}. |
| Q63HN8 | RNF213 | T225 | ochoa | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213) | Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:21799892, PubMed:26126547, PubMed:26278786, PubMed:26766444, PubMed:30705059, PubMed:32139119, PubMed:34012115). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (PubMed:34012115). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (PubMed:34012115). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (PubMed:30705059). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (PubMed:30846318). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (PubMed:32139119, PubMed:33842849). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:34012115). {ECO:0000269|PubMed:21799892, ECO:0000269|PubMed:26126547, ECO:0000269|PubMed:26278786, ECO:0000269|PubMed:26766444, ECO:0000269|PubMed:30705059, ECO:0000269|PubMed:30846318, ECO:0000269|PubMed:32139119, ECO:0000269|PubMed:33842849, ECO:0000269|PubMed:34012115}. |
| Q63ZY3 | KANK2 | T573 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q641Q2 | WASHC2A | T1092 | ochoa | WASH complex subunit 2A | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L. {ECO:0000269|PubMed:25355947, ECO:0000269|PubMed:28892079}. |
| Q6FIF0 | ZFAND6 | T117 | ochoa | AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3) | Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}. |
| Q6P2E9 | EDC4 | T816 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6PFW1 | PPIP5K1 | T940 | ochoa | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1) | Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}. |
| Q6RW13 | AGTRAP | T135 | ochoa | Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) | Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}. |
| Q6UB99 | ANKRD11 | T1419 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UXT9 | ABHD15 | T421 | ochoa | Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) | May regulate adipocyte lipolysis and liver lipid accumulation. {ECO:0000250|UniProtKB:Q5F2F2}. |
| Q6XZF7 | DNMBP | T370 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZNJ1 | NBEAL2 | T1869 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZRS2 | SRCAP | T2884 | ochoa | Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator) | Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269|PubMed:10347196, ECO:0000269|PubMed:11522779, ECO:0000269|PubMed:14500758, ECO:0000269|PubMed:16024792, ECO:0000269|PubMed:16634648, ECO:0000269|PubMed:17617668}. |
| Q7Z3J3 | RGPD4 | T1226 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z7B0 | FILIP1 | T883 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q86X53 | ERICH1 | T56 | ochoa | Glutamate-rich protein 1 | None |
| Q86YT9 | JAML | T258 | ochoa | Junctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1) | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}. |
| Q8IVH8 | MAP4K3 | T458 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| Q8IWU2 | LMTK2 | T602 | ochoa | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Q8IZL8 | PELP1 | T1014 | ochoa | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}. |
| Q8N163 | CCAR2 | T454 | ochoa|psp | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N163 | CCAR2 | T489 | ochoa | Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC) | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (PubMed:22446626). Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis (PubMed:18235501, PubMed:18235502, PubMed:23352644). Inhibits SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress (PubMed:23398316). Regulates the circadian expression of the core clock components NR1D1 and BMAL1 (PubMed:23398316). Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978). {ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18235502, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:22446626, ECO:0000269|PubMed:23352644, ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:25732823}. |
| Q8N1F7 | NUP93 | T159 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N8Z6 | DCBLD1 | T572 | ochoa | Discoidin, CUB and LCCL domain-containing protein 1 | None |
| Q8TAQ2 | SMARCC2 | T390 | ochoa | SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity). {ECO:0000250|UniProtKB:Q6PDG5, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000269|PubMed:12192000, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
| Q8TF44 | C2CD4C | T73 | ochoa | C2 calcium-dependent domain-containing protein 4C (Nuclear-localized factor 3) (Protein FAM148C) | None |
| Q8WWI1 | LMO7 | T818 | ochoa | LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) | None |
| Q92797 | SYMPK | T1246 | ochoa | Symplekin | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}. |
| Q92973 | TNPO1 | T335 | ochoa | Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975}. |
| Q96C86 | DCPS | T25 | ochoa | m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) | Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. {ECO:0000269|PubMed:11747811, ECO:0000269|PubMed:12198172, ECO:0000269|PubMed:12871939, ECO:0000269|PubMed:14523240, ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:15383679, ECO:0000269|PubMed:15769464, ECO:0000269|PubMed:16140270, ECO:0000269|PubMed:18426921, ECO:0000269|PubMed:22985415}. |
| Q96F86 | EDC3 | T224 | ochoa | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}. |
| Q96NY8 | NECTIN4 | T393 | ochoa | Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4] | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; FUNCTION: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}. |
| Q96RL1 | UIMC1 | T396 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96S90 | LYSMD1 | T121 | ochoa | LysM and putative peptidoglycan-binding domain-containing protein 1 | None |
| Q99666 | RGPD5 | T1225 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99708 | RBBP8 | T859 | psp | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}. |
| Q9BQG0 | MYBBP1A | T946 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BW04 | SARG | T78 | ochoa | Specifically androgen-regulated gene protein | Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}. |
| Q9BYB0 | SHANK3 | T1234 | ochoa | SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:24132240}. |
| Q9C0C2 | TNKS1BP1 | T1430 | ochoa | 182 kDa tankyrase-1-binding protein | None |
| Q9H0E9 | BRD8 | T617 | ochoa | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
| Q9H4Z2 | ZNF335 | T1160 | ochoa | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (PubMed:19131338, PubMed:23178126). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:12215545, PubMed:18180299, PubMed:19131338). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST (PubMed:23178126). Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation (PubMed:23178126). {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:23178126}. |
| Q9NPQ8 | RIC8A | T443 | ochoa | Chaperone Ric-8A (Synembryn-A) | Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}. |
| Q9NTI7 | INKA2 | T265 | ochoa | PAK4-inhibitor INKA2 (Induced in neural crest by AP2-alpha protein-related homolog) (Inca-r) (Inka-box actin regulator 2) | Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity. {ECO:0000250|UniProtKB:Q96EL1}. |
| Q9NUY8 | TBC1D23 | T562 | ochoa | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. |
| Q9NYL2 | MAP3K20 | T161 | psp | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9P2K3 | RCOR3 | T384 | ochoa | REST corepressor 3 | May act as a component of a corepressor complex that represses transcription. {ECO:0000305}. |
| Q9UGY1 | NOL12 | T141 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. |
| Q9UKV8 | AGO2 | T303 | psp | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. {ECO:0000250|UniProtKB:Q8CJG0, ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:15105377, ECO:0000269|PubMed:15260970, ECO:0000269|PubMed:15284456, ECO:0000269|PubMed:15337849, ECO:0000269|PubMed:15800637, ECO:0000269|PubMed:16081698, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16756390, ECO:0000269|PubMed:16936728, ECO:0000269|PubMed:17382880, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:17524464, ECO:0000269|PubMed:17531811, ECO:0000269|PubMed:17932509, ECO:0000269|PubMed:18048652, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:18690212, ECO:0000269|PubMed:18771919, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:23746446, ECO:0000269|PubMed:37328606}.; FUNCTION: (Microbial infection) Upon Sars-CoV-2 infection, associates with viral miRNA-like small RNA, CoV2-miR-O7a, and may repress mRNAs, such as BATF2, to evade the IFN response. {ECO:0000269|PubMed:34903581}. |
| Q9UNX4 | WDR3 | T257 | ochoa | WD repeat-containing protein 3 | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000269|PubMed:34516797}. |
| Q9UPR0 | PLCL2 | T584 | ochoa | Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. {ECO:0000250}. |
| Q9Y2F5 | ICE1 | T1859 | ochoa | Little elongation complex subunit 1 (Interactor of little elongator complex ELL subunit 1) | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780). {ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. |
| Q9Y490 | TLN1 | T23 | ochoa | Talin-1 | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. {ECO:0000250|UniProtKB:P26039}. |
| Q9Y5B6 | PAXBP1 | T565 | ochoa | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. {ECO:0000250|UniProtKB:P58501}. |
| Q9Y6R0 | NUMBL | T333 | ochoa | Numb-like protein (Numb-related protein) (Numb-R) | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269|PubMed:18299187, ECO:0000269|PubMed:20079715}. |
| V9GYY5 | None | T134 | ochoa | Nucleolar protein 12 | Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly. {ECO:0000256|ARBA:ARBA00057078}. |
| P04406 | GAPDH | T104 | Sugiyama | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:11724794, PubMed:3170585). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:11724794, PubMed:3170585). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (By similarity). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity). {ECO:0000250|UniProtKB:P04797, ECO:0000269|PubMed:11724794, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23332158, ECO:0000269|PubMed:27387501, ECO:0000269|PubMed:3170585}. |
| P47712 | PLA2G4A | T425 | Sugiyama | Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] | Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891). {ECO:0000250|UniProtKB:P47713, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:12672805, ECO:0000269|PubMed:14709560, ECO:0000269|PubMed:16617059, ECO:0000269|PubMed:17472963, ECO:0000269|PubMed:18451993, ECO:0000269|PubMed:27642067, ECO:0000269|PubMed:7794891, ECO:0000269|PubMed:8619991, ECO:0000269|PubMed:8702602, ECO:0000269|PubMed:9425121}. |
| O94776 | MTA2 | T417 | Sugiyama | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}. |
| P05129 | PRKCG | T510 | Sugiyama | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). {ECO:0000250|UniProtKB:P63318, ECO:0000250|UniProtKB:P63319, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:36040231}. |
| Q00341 | HDLBP | T39 | Sugiyama | Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) | Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol. |
| P06493 | CDK1 | T47 | Sugiyama | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19202191, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25012651, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30704899, PubMed:32351706, PubMed:34741373). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007). Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007, PubMed:2188730, PubMed:2344612, PubMed:30139873). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188730, PubMed:2344612, PubMed:37788673). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706). Phosphorylates SKA3 on multiple sites during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (PubMed:28479321, PubMed:31804178, PubMed:32491969). {ECO:0000250|UniProtKB:P11440, ECO:0000250|UniProtKB:P39951, ECO:0000269|PubMed:16371510, ECO:0000269|PubMed:16407259, ECO:0000269|PubMed:16933150, ECO:0000269|PubMed:17459720, ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:18480403, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19509060, ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:20171170, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:20937773, ECO:0000269|PubMed:21063390, ECO:0000269|PubMed:2188730, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:2344612, ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:25012651, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26549230, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:28479321, ECO:0000269|PubMed:30139873, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:30723163, ECO:0000269|PubMed:31804178, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:32491969, ECO:0000269|PubMed:34741373, ECO:0000269|PubMed:37788673}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. {ECO:0000269|PubMed:21516087}. |
| P52888 | THOP1 | T76 | Sugiyama | Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:17251185, PubMed:7639763). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:17251185, PubMed:7639763). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000269|PubMed:17251185, ECO:0000269|PubMed:7639763}. |
| P30281 | CCND3 | T120 | Sugiyama | G1/S-specific cyclin-D3 | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:8114739). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:8114739). Hypophosphorylates RB1 in early G(1) phase (PubMed:8114739). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739). Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:16782892). Shows transcriptional coactivator activity with ATF5 independently of CDK4 (PubMed:15358120). {ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:8114739}. |
| P30101 | PDIA3 | T120 | Sugiyama | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323). {ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:27897272, ECO:0000269|PubMed:35948544, ECO:0000269|PubMed:36104323, ECO:0000269|PubMed:7487104}. |
| P19525 | EIF2AK2 | T529 | Sugiyama | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| P11586 | MTHFD1 | T511 | Sugiyama | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:18767138, PubMed:25633902). {ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:18767138, ECO:0000269|PubMed:1881876, ECO:0000269|PubMed:25633902}. |
| P24941 | CDK2 | T47 | Sugiyama | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:17495531, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226, PubMed:28666995). Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2 (PubMed:10499802, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431, PubMed:15800615, PubMed:19966300, PubMed:20935635, PubMed:21262353, PubMed:21596315, PubMed:28216226). Triggers duplication of centrosomes and DNA (PubMed:11051553). Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus (PubMed:18372919, PubMed:19238148, PubMed:19561645). Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs) (PubMed:18372919, PubMed:19238148, PubMed:19561645). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase (PubMed:18372919, PubMed:19238148, PubMed:19561645). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC (PubMed:19966300). Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis (PubMed:15800615, PubMed:20195506, PubMed:21319273). In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation (PubMed:15800615). Involved in regulation of telomere repair by mediating phosphorylation of NBN (PubMed:28216226). Phosphorylation of RB1 disturbs its interaction with E2F1 (PubMed:10499802). NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication (PubMed:11051553). Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase (PubMed:10995386, PubMed:10995387). Required for vitamin D-mediated growth inhibition by being itself inactivated (PubMed:20147522). Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner (PubMed:20079829). USP37 is activated by phosphorylation and thus triggers G1-S transition (PubMed:21596315). CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of the C-terminus of protein kinase B (PKB/AKT1 and PKB/AKT2), promoting its activation (PubMed:24670654). {ECO:0000250|UniProtKB:P97377, ECO:0000269|PubMed:10499802, ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:11051553, ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:12944431, ECO:0000269|PubMed:15800615, ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:18372919, ECO:0000269|PubMed:19966300, ECO:0000269|PubMed:20079829, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20195506, ECO:0000269|PubMed:20935635, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:21319273, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:28216226, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:29203878, ECO:0000303|PubMed:19238148, ECO:0000303|PubMed:19561645}. |
| P14314 | PRKCSH | T103 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
| P04083 | ANXA1 | T265 | Sugiyama | Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26] | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619, ECO:0000269|PubMed:17008549, ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504, ECO:0000269|PubMed:2936963, ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:22879591, ECO:0000269|PubMed:25664854}. |
| P80192 | MAP3K9 | T304 | GPS6|EPSD | Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}. |
| P23396 | RPS3 | T26 | Sugiyama | Small ribosomal subunit protein uS3 (40S ribosomal protein S3) (EC 4.2.99.18) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:8706699). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408). {ECO:0000269|PubMed:14706345, ECO:0000269|PubMed:14988002, ECO:0000269|PubMed:15518571, ECO:0000269|PubMed:15707971, ECO:0000269|PubMed:17049931, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:18610840, ECO:0000269|PubMed:18973764, ECO:0000269|PubMed:19656744, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:20605787, ECO:0000269|PubMed:22510408, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:23911537, ECO:0000269|PubMed:7775413, ECO:0000269|PubMed:8706699}. |
| Q32MK0 | MYLK3 | T361 | Sugiyama | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). {ECO:0000250}. |
| Q9UJW0 | DCTN4 | T141 | Sugiyama | Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. {ECO:0000250|UniProtKB:A0A4X1TB62}. |
| P46013 | MKI67 | T2094 | Sugiyama | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| Q9HDC9 | APMAP | T131 | Sugiyama | Adipocyte plasma membrane-associated protein (Protein BSCv) | Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation. {ECO:0000269|PubMed:18513186}. |
| Q6P1R4 | DUS1L | T365 | Sugiyama | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.88) (tRNA-dihydrouridine synthase 1-like) | Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:34798057, PubMed:39354220). Specifically modifies U16 and U17 in cytoplasmic tRNAs (PubMed:39354220). Affects the level of some mature tRNA and thereby the total cellular translation (PubMed:39354220). {ECO:0000269|PubMed:34798057, ECO:0000269|PubMed:39354220}. |
| P14314 | PRKCSH | T494 | Sugiyama | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:O08795, ECO:0000269|PubMed:10929008}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-9706377 | FLT3 signaling by CBL mutants | 8.674503e-07 | 6.062 |
| R-HSA-209560 | NF-kB is activated and signals survival | 4.946559e-07 | 6.306 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 6.033128e-07 | 6.219 |
| R-HSA-9664873 | Pexophagy | 2.457359e-07 | 6.610 |
| R-HSA-209543 | p75NTR recruits signalling complexes | 6.776340e-07 | 6.169 |
| R-HSA-69620 | Cell Cycle Checkpoints | 8.436618e-07 | 6.074 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 4.664097e-07 | 6.331 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 3.809694e-07 | 6.419 |
| R-HSA-9700206 | Signaling by ALK in cancer | 3.809694e-07 | 6.419 |
| R-HSA-5689901 | Metalloprotease DUBs | 9.684820e-07 | 6.014 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 1.473425e-06 | 5.832 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 1.473425e-06 | 5.832 |
| R-HSA-193639 | p75NTR signals via NF-kB | 1.562472e-06 | 5.806 |
| R-HSA-205043 | NRIF signals cell death from the nucleus | 1.201867e-06 | 5.920 |
| R-HSA-9683683 | Maturation of protein E | 1.468503e-06 | 5.833 |
| R-HSA-9694493 | Maturation of protein E | 1.468503e-06 | 5.833 |
| R-HSA-69481 | G2/M Checkpoints | 1.838656e-06 | 5.735 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 2.116027e-06 | 5.674 |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | 4.829048e-06 | 5.316 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 2.711459e-06 | 5.567 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 3.019147e-06 | 5.520 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 3.518851e-06 | 5.454 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 3.722392e-06 | 5.429 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 4.122209e-06 | 5.385 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 5.215228e-06 | 5.283 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 5.129546e-06 | 5.290 |
| R-HSA-8948747 | Regulation of PTEN localization | 3.530554e-06 | 5.452 |
| R-HSA-3785653 | Myoclonic epilepsy of Lafora | 5.129546e-06 | 5.290 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 5.129546e-06 | 5.290 |
| R-HSA-901042 | Calnexin/calreticulin cycle | 3.982936e-06 | 5.400 |
| R-HSA-418597 | G alpha (z) signalling events | 3.722392e-06 | 5.429 |
| R-HSA-68882 | Mitotic Anaphase | 4.784334e-06 | 5.320 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 4.991127e-06 | 5.302 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 5.215228e-06 | 5.283 |
| R-HSA-8953854 | Metabolism of RNA | 4.086097e-06 | 5.389 |
| R-HSA-9637628 | Modulation by Mtb of host immune system | 5.129546e-06 | 5.290 |
| R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | 5.129546e-06 | 5.290 |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | 7.092199e-06 | 5.149 |
| R-HSA-937042 | IRAK2 mediated activation of TAK1 complex | 7.209404e-06 | 5.142 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 7.628805e-06 | 5.118 |
| R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex | 9.854054e-06 | 5.006 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 9.720248e-06 | 5.012 |
| R-HSA-5689877 | Josephin domain DUBs | 9.854054e-06 | 5.006 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 1.087770e-05 | 4.963 |
| R-HSA-162909 | Host Interactions of HIV factors | 1.117311e-05 | 4.952 |
| R-HSA-112040 | G-protein mediated events | 1.143068e-05 | 4.942 |
| R-HSA-9645460 | Alpha-protein kinase 1 signaling pathway | 1.315291e-05 | 4.881 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 1.315291e-05 | 4.881 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 1.360666e-05 | 4.866 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 1.516478e-05 | 4.819 |
| R-HSA-69231 | Cyclin D associated events in G1 | 1.516478e-05 | 4.819 |
| R-HSA-69236 | G1 Phase | 1.516478e-05 | 4.819 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 1.720060e-05 | 4.764 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 1.686387e-05 | 4.773 |
| R-HSA-5610787 | Hedgehog 'off' state | 1.716643e-05 | 4.765 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 1.720060e-05 | 4.764 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 1.723678e-05 | 4.764 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.864915e-05 | 4.729 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 1.909880e-05 | 4.719 |
| R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling | 2.209676e-05 | 4.656 |
| R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants | 2.209676e-05 | 4.656 |
| R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer | 2.209676e-05 | 4.656 |
| R-HSA-937039 | IRAK1 recruits IKK complex | 2.209676e-05 | 4.656 |
| R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | 2.209676e-05 | 4.656 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 2.209676e-05 | 4.656 |
| R-HSA-9634597 | GPER1 signaling | 2.290293e-05 | 4.640 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 2.526387e-05 | 4.598 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 2.526387e-05 | 4.598 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 2.526387e-05 | 4.598 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 2.495597e-05 | 4.603 |
| R-HSA-5205685 | PINK1-PRKN Mediated Mitophagy | 2.545482e-05 | 4.594 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.586678e-05 | 4.587 |
| R-HSA-174490 | Membrane binding and targetting of GAG proteins | 2.794571e-05 | 4.554 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 3.793743e-05 | 4.421 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 3.485630e-05 | 4.458 |
| R-HSA-68949 | Orc1 removal from chromatin | 3.354477e-05 | 4.474 |
| R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins | 3.485630e-05 | 4.458 |
| R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation | 3.485630e-05 | 4.458 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 3.793743e-05 | 4.421 |
| R-HSA-1500931 | Cell-Cell communication | 3.368039e-05 | 4.473 |
| R-HSA-1640170 | Cell Cycle | 3.795417e-05 | 4.421 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 4.294162e-05 | 4.367 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 4.294162e-05 | 4.367 |
| R-HSA-110312 | Translesion synthesis by REV1 | 4.294162e-05 | 4.367 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 4.018347e-05 | 4.396 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 4.179643e-05 | 4.379 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 4.253481e-05 | 4.371 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 4.294162e-05 | 4.367 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 4.294162e-05 | 4.367 |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | 4.294162e-05 | 4.367 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 4.294162e-05 | 4.367 |
| R-HSA-5656121 | Translesion synthesis by POLI | 5.231879e-05 | 4.281 |
| R-HSA-9758274 | Regulation of NF-kappa B signaling | 5.231879e-05 | 4.281 |
| R-HSA-446728 | Cell junction organization | 4.663409e-05 | 4.331 |
| R-HSA-9708530 | Regulation of BACH1 activity | 5.231879e-05 | 4.281 |
| R-HSA-9706369 | Negative regulation of FLT3 | 5.231879e-05 | 4.281 |
| R-HSA-68886 | M Phase | 5.316922e-05 | 4.274 |
| R-HSA-5655862 | Translesion synthesis by POLK | 6.310874e-05 | 4.200 |
| R-HSA-5693538 | Homology Directed Repair | 5.770507e-05 | 4.239 |
| R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA | 6.310874e-05 | 4.200 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 5.470775e-05 | 4.262 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 6.140910e-05 | 4.212 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 6.140910e-05 | 4.212 |
| R-HSA-1236974 | ER-Phagosome pathway | 6.156564e-05 | 4.211 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 6.146171e-05 | 4.211 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 6.310874e-05 | 4.200 |
| R-HSA-392518 | Signal amplification | 6.140910e-05 | 4.212 |
| R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | 6.310874e-05 | 4.200 |
| R-HSA-5205647 | Mitophagy | 6.140910e-05 | 4.212 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 6.737829e-05 | 4.171 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 6.872665e-05 | 4.163 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 6.872665e-05 | 4.163 |
| R-HSA-169911 | Regulation of Apoptosis | 6.872665e-05 | 4.163 |
| R-HSA-2559585 | Oncogene Induced Senescence | 6.872665e-05 | 4.163 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 8.536395e-05 | 4.069 |
| R-HSA-4641258 | Degradation of DVL | 8.536395e-05 | 4.069 |
| R-HSA-4641263 | Regulation of FZD by ubiquitination | 7.543599e-05 | 4.122 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 7.669850e-05 | 4.115 |
| R-HSA-4641257 | Degradation of AXIN | 8.536395e-05 | 4.069 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 8.536395e-05 | 4.069 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 8.942846e-05 | 4.049 |
| R-HSA-69278 | Cell Cycle, Mitotic | 7.884664e-05 | 4.103 |
| R-HSA-69206 | G1/S Transition | 8.648186e-05 | 4.063 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 8.536395e-05 | 4.069 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 8.427163e-05 | 4.074 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 7.802341e-05 | 4.108 |
| R-HSA-5683057 | MAPK family signaling cascades | 8.167938e-05 | 4.088 |
| R-HSA-3229121 | Glycogen storage diseases | 7.543599e-05 | 4.122 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 8.427163e-05 | 4.074 |
| R-HSA-8848021 | Signaling by PTK6 | 8.427163e-05 | 4.074 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 8.942846e-05 | 4.049 |
| R-HSA-2467813 | Separation of Sister Chromatids | 9.347853e-05 | 4.029 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 1.049386e-04 | 3.979 |
| R-HSA-69541 | Stabilization of p53 | 1.049386e-04 | 3.979 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 1.049386e-04 | 3.979 |
| R-HSA-110320 | Translesion Synthesis by POLH | 1.052172e-04 | 3.978 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.052172e-04 | 3.978 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.052172e-04 | 3.978 |
| R-HSA-5693606 | DNA Double Strand Break Response | 1.133658e-04 | 3.946 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 1.427227e-04 | 3.846 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 1.400151e-04 | 3.854 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 1.405512e-04 | 3.852 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 1.405512e-04 | 3.852 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 1.405512e-04 | 3.852 |
| R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human ... | 1.427227e-04 | 3.846 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.159322e-04 | 3.936 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 1.159322e-04 | 3.936 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 1.277881e-04 | 3.894 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 1.277881e-04 | 3.894 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.229364e-04 | 3.910 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 1.277881e-04 | 3.894 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.252722e-04 | 3.902 |
| R-HSA-9636383 | Prevention of phagosomal-lysosomal fusion | 1.427227e-04 | 3.846 |
| R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus | 1.427227e-04 | 3.846 |
| R-HSA-9931295 | PD-L1(CD274) glycosylation and translocation to plasma membrane | 1.427227e-04 | 3.846 |
| R-HSA-3322077 | Glycogen synthesis | 1.229364e-04 | 3.910 |
| R-HSA-9683701 | Translation of Structural Proteins | 1.405512e-04 | 3.852 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 1.427227e-04 | 3.846 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 1.427227e-04 | 3.846 |
| R-HSA-5632684 | Hedgehog 'on' state | 1.499230e-04 | 3.824 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 1.603780e-04 | 3.795 |
| R-HSA-111885 | Opioid Signalling | 1.641480e-04 | 3.785 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 1.647157e-04 | 3.783 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.647157e-04 | 3.783 |
| R-HSA-175474 | Assembly Of The HIV Virion | 1.647157e-04 | 3.783 |
| R-HSA-450302 | activated TAK1 mediates p38 MAPK activation | 1.647157e-04 | 3.783 |
| R-HSA-9705462 | Inactivation of CSF3 (G-CSF) signaling | 1.647157e-04 | 3.783 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 1.689845e-04 | 3.772 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 1.714014e-04 | 3.766 |
| R-HSA-5358351 | Signaling by Hedgehog | 1.724835e-04 | 3.763 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 1.829352e-04 | 3.738 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 1.890573e-04 | 3.723 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 1.890573e-04 | 3.723 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 1.918122e-04 | 3.717 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 2.016136e-04 | 3.695 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.016136e-04 | 3.695 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.016136e-04 | 3.695 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 2.016136e-04 | 3.695 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 2.016136e-04 | 3.695 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 2.122627e-04 | 3.673 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 2.196254e-04 | 3.658 |
| R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | 2.196254e-04 | 3.658 |
| R-HSA-4086400 | PCP/CE pathway | 2.358306e-04 | 3.627 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 2.388368e-04 | 3.622 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 2.453645e-04 | 3.610 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.367902e-04 | 3.473 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 3.316949e-04 | 3.479 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 3.041963e-04 | 3.517 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 3.287387e-04 | 3.483 |
| R-HSA-9766229 | Degradation of CDH1 | 2.810685e-04 | 3.551 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 3.287387e-04 | 3.483 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 3.069199e-04 | 3.513 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 3.287387e-04 | 3.483 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 3.128210e-04 | 3.505 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 3.128210e-04 | 3.505 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 3.511056e-04 | 3.455 |
| R-HSA-901032 | ER Quality Control Compartment (ERQC) | 3.511056e-04 | 3.455 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 3.511056e-04 | 3.455 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 3.547517e-04 | 3.450 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 3.822923e-04 | 3.418 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 3.822923e-04 | 3.418 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 3.926312e-04 | 3.406 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 3.985588e-04 | 3.400 |
| R-HSA-421270 | Cell-cell junction organization | 4.003874e-04 | 3.398 |
| R-HSA-3371556 | Cellular response to heat stress | 4.283122e-04 | 3.368 |
| R-HSA-5633007 | Regulation of TP53 Activity | 4.315926e-04 | 3.365 |
| R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) | 4.375516e-04 | 3.359 |
| R-HSA-9615710 | Late endosomal microautophagy | 4.375516e-04 | 3.359 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 4.375516e-04 | 3.359 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 4.375516e-04 | 3.359 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 4.375516e-04 | 3.359 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 4.746626e-04 | 3.324 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 4.746626e-04 | 3.324 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 4.860222e-04 | 3.313 |
| R-HSA-9764561 | Regulation of CDH1 Function | 5.089005e-04 | 3.293 |
| R-HSA-162588 | Budding and maturation of HIV virion | 5.381991e-04 | 3.269 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 5.381991e-04 | 3.269 |
| R-HSA-182971 | EGFR downregulation | 5.381991e-04 | 3.269 |
| R-HSA-6782135 | Dual incision in TC-NER | 5.449635e-04 | 3.264 |
| R-HSA-9033241 | Peroxisomal protein import | 5.829135e-04 | 3.234 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 5.942394e-04 | 3.226 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 6.543007e-04 | 3.184 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 6.543007e-04 | 3.184 |
| R-HSA-418990 | Adherens junctions interactions | 6.564796e-04 | 3.183 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 6.647256e-04 | 3.177 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 6.704736e-04 | 3.174 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 7.047841e-04 | 3.152 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 7.047841e-04 | 3.152 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 7.185415e-04 | 3.144 |
| R-HSA-9909396 | Circadian clock | 7.332250e-04 | 3.135 |
| R-HSA-913531 | Interferon Signaling | 7.371549e-04 | 3.132 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 7.532038e-04 | 3.123 |
| R-HSA-5696400 | Dual Incision in GG-NER | 7.871205e-04 | 3.104 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 7.871205e-04 | 3.104 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 7.871205e-04 | 3.104 |
| R-HSA-1980145 | Signaling by NOTCH2 | 7.871205e-04 | 3.104 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 7.871205e-04 | 3.104 |
| R-HSA-162906 | HIV Infection | 8.509354e-04 | 3.070 |
| R-HSA-1234174 | Cellular response to hypoxia | 8.537949e-04 | 3.069 |
| R-HSA-168255 | Influenza Infection | 8.580818e-04 | 3.066 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 8.601968e-04 | 3.065 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 8.751647e-04 | 3.058 |
| R-HSA-70171 | Glycolysis | 8.917972e-04 | 3.050 |
| R-HSA-9020702 | Interleukin-1 signaling | 9.335809e-04 | 3.030 |
| R-HSA-9682385 | FLT3 signaling in disease | 9.379298e-04 | 3.028 |
| R-HSA-9948299 | Ribosome-associated quality control | 9.571410e-04 | 3.019 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 9.621017e-04 | 3.017 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.200664e-03 | 2.921 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.298618e-03 | 2.887 |
| R-HSA-9646399 | Aggrephagy | 1.298618e-03 | 2.887 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 1.402025e-03 | 2.853 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 1.298618e-03 | 2.887 |
| R-HSA-6807070 | PTEN Regulation | 9.930977e-04 | 3.003 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 1.137189e-03 | 2.944 |
| R-HSA-69275 | G2/M Transition | 1.069646e-03 | 2.971 |
| R-HSA-418594 | G alpha (i) signalling events | 1.204472e-03 | 2.919 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 9.768562e-04 | 3.010 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.200664e-03 | 2.921 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 1.108004e-03 | 2.955 |
| R-HSA-69239 | Synthesis of DNA | 1.269843e-03 | 2.896 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 1.381086e-03 | 2.860 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 1.278565e-03 | 2.893 |
| R-HSA-9833110 | RSV-host interactions | 1.115988e-03 | 2.952 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 1.442224e-03 | 2.841 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.143289e-03 | 2.942 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.143289e-03 | 2.942 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 1.147696e-03 | 2.940 |
| R-HSA-9013694 | Signaling by NOTCH4 | 1.422724e-03 | 2.847 |
| R-HSA-2262752 | Cellular responses to stress | 1.455265e-03 | 2.837 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.180167e-03 | 2.928 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.147696e-03 | 2.940 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 1.020479e-03 | 2.991 |
| R-HSA-8982491 | Glycogen metabolism | 1.298618e-03 | 2.887 |
| R-HSA-9648002 | RAS processing | 1.200664e-03 | 2.921 |
| R-HSA-5663084 | Diseases of carbohydrate metabolism | 1.348601e-03 | 2.870 |
| R-HSA-9607240 | FLT3 Signaling | 1.402025e-03 | 2.853 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 1.499808e-03 | 2.824 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 1.511043e-03 | 2.821 |
| R-HSA-5689603 | UCH proteinases | 1.579924e-03 | 2.801 |
| R-HSA-1980143 | Signaling by NOTCH1 | 1.579924e-03 | 2.801 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.617434e-03 | 2.791 |
| R-HSA-991365 | Activation of GABAB receptors | 1.625831e-03 | 2.789 |
| R-HSA-977444 | GABA B receptor activation | 1.625831e-03 | 2.789 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 1.625831e-03 | 2.789 |
| R-HSA-9694635 | Translation of Structural Proteins | 1.663144e-03 | 2.779 |
| R-HSA-73887 | Death Receptor Signaling | 1.727141e-03 | 2.763 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 1.746546e-03 | 2.758 |
| R-HSA-5654743 | Signaling by FGFR4 | 1.746546e-03 | 2.758 |
| R-HSA-5619084 | ABC transporter disorders | 1.749539e-03 | 2.757 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 1.784121e-03 | 2.749 |
| R-HSA-909733 | Interferon alpha/beta signaling | 1.902088e-03 | 2.721 |
| R-HSA-162587 | HIV Life Cycle | 1.902458e-03 | 2.721 |
| R-HSA-6783310 | Fanconi Anemia Pathway | 2.006381e-03 | 2.698 |
| R-HSA-5654741 | Signaling by FGFR3 | 2.006381e-03 | 2.698 |
| R-HSA-70326 | Glucose metabolism | 2.052919e-03 | 2.688 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 2.128313e-03 | 2.672 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 2.128313e-03 | 2.672 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 2.145813e-03 | 2.668 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 2.145813e-03 | 2.668 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 2.145813e-03 | 2.668 |
| R-HSA-6802949 | Signaling by RAS mutants | 2.145813e-03 | 2.668 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 2.145813e-03 | 2.668 |
| R-HSA-9861718 | Regulation of pyruvate metabolism | 2.145813e-03 | 2.668 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 2.212624e-03 | 2.655 |
| R-HSA-109581 | Apoptosis | 2.225008e-03 | 2.653 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 2.231669e-03 | 2.651 |
| R-HSA-445989 | TAK1-dependent IKK and NF-kappa-B activation | 2.291794e-03 | 2.640 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 2.338635e-03 | 2.631 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 2.381532e-03 | 2.623 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 2.449285e-03 | 2.611 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 2.563692e-03 | 2.591 |
| R-HSA-73893 | DNA Damage Bypass | 2.604012e-03 | 2.584 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.604012e-03 | 2.584 |
| R-HSA-162582 | Signal Transduction | 2.663922e-03 | 2.574 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.910448e-03 | 2.536 |
| R-HSA-9663891 | Selective autophagy | 2.930191e-03 | 2.533 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 3.125248e-03 | 2.505 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 3.125248e-03 | 2.505 |
| R-HSA-202424 | Downstream TCR signaling | 3.194656e-03 | 2.496 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 3.285477e-03 | 2.483 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 3.623021e-03 | 2.441 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 3.623021e-03 | 2.441 |
| R-HSA-9012852 | Signaling by NOTCH3 | 3.713529e-03 | 2.430 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.774549e-03 | 2.423 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 3.824556e-03 | 2.417 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 3.849709e-03 | 2.415 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 3.879087e-03 | 2.411 |
| R-HSA-75893 | TNF signaling | 3.925199e-03 | 2.406 |
| R-HSA-177929 | Signaling by EGFR | 3.925199e-03 | 2.406 |
| R-HSA-5654736 | Signaling by FGFR1 | 3.925199e-03 | 2.406 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 4.144893e-03 | 2.382 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 4.256370e-03 | 2.371 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 4.426300e-03 | 2.354 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 4.509469e-03 | 2.346 |
| R-HSA-195721 | Signaling by WNT | 4.597944e-03 | 2.337 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 4.601013e-03 | 2.337 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 4.601013e-03 | 2.337 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 4.608913e-03 | 2.336 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 4.755933e-03 | 2.323 |
| R-HSA-977443 | GABA receptor activation | 4.853513e-03 | 2.314 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 4.853513e-03 | 2.314 |
| R-HSA-1227986 | Signaling by ERBB2 | 4.853513e-03 | 2.314 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 4.853513e-03 | 2.314 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 4.853513e-03 | 2.314 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 4.853513e-03 | 2.314 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 4.853513e-03 | 2.314 |
| R-HSA-450294 | MAP kinase activation | 5.106687e-03 | 2.292 |
| R-HSA-382556 | ABC-family proteins mediated transport | 5.154568e-03 | 2.288 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 5.328543e-03 | 2.273 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 5.349132e-03 | 2.272 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 5.666357e-03 | 2.247 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 5.918969e-03 | 2.228 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 6.107987e-03 | 2.214 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 6.107987e-03 | 2.214 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 6.207748e-03 | 2.207 |
| R-HSA-5696398 | Nucleotide Excision Repair | 6.400492e-03 | 2.194 |
| R-HSA-69242 | S Phase | 6.429367e-03 | 2.192 |
| R-HSA-1538133 | G0 and Early G1 | 6.569642e-03 | 2.182 |
| R-HSA-376176 | Signaling by ROBO receptors | 6.875319e-03 | 2.163 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 7.051544e-03 | 2.152 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 7.051544e-03 | 2.152 |
| R-HSA-5218859 | Regulated Necrosis | 7.129891e-03 | 2.147 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 7.181932e-03 | 2.144 |
| R-HSA-446652 | Interleukin-1 family signaling | 7.184648e-03 | 2.144 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 1.254398e-02 | 1.902 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 7.553901e-03 | 2.122 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 8.494109e-03 | 2.071 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 8.859985e-03 | 2.053 |
| R-HSA-8852135 | Protein ubiquitination | 9.622292e-03 | 2.017 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 1.073036e-02 | 1.969 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.015160e-02 | 1.993 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 1.302432e-02 | 1.885 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 8.138274e-03 | 2.089 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 1.357690e-02 | 1.867 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 1.374020e-02 | 1.862 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 1.254398e-02 | 1.902 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 9.771652e-03 | 2.010 |
| R-HSA-418555 | G alpha (s) signalling events | 1.194935e-02 | 1.923 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 7.553901e-03 | 2.122 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 1.223447e-02 | 1.912 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.138269e-02 | 1.944 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 1.072918e-02 | 1.969 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 1.072918e-02 | 1.969 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 1.171941e-02 | 1.931 |
| R-HSA-8951664 | Neddylation | 1.048201e-02 | 1.980 |
| R-HSA-72312 | rRNA processing | 1.311335e-02 | 1.882 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 1.171941e-02 | 1.931 |
| R-HSA-73894 | DNA Repair | 1.372110e-02 | 1.863 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 8.076911e-03 | 2.093 |
| R-HSA-111996 | Ca-dependent events | 1.374020e-02 | 1.862 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 9.236010e-03 | 2.035 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 1.027680e-02 | 1.988 |
| R-HSA-180746 | Nuclear import of Rev protein | 8.076911e-03 | 2.093 |
| R-HSA-388396 | GPCR downstream signalling | 1.260696e-02 | 1.899 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 1.254398e-02 | 1.902 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.165825e-02 | 1.933 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.165825e-02 | 1.933 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.233037e-02 | 1.909 |
| R-HSA-9006936 | Signaling by TGFB family members | 8.884770e-03 | 2.051 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.037901e-02 | 1.984 |
| R-HSA-114608 | Platelet degranulation | 1.388291e-02 | 1.858 |
| R-HSA-69306 | DNA Replication | 7.383091e-03 | 2.132 |
| R-HSA-977225 | Amyloid fiber formation | 1.216107e-02 | 1.915 |
| R-HSA-9711123 | Cellular response to chemical stress | 8.226683e-03 | 2.085 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 1.252435e-02 | 1.902 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 1.252435e-02 | 1.902 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 1.436962e-02 | 1.843 |
| R-HSA-448424 | Interleukin-17 signaling | 7.792368e-03 | 2.108 |
| R-HSA-109582 | Hemostasis | 1.397973e-02 | 1.855 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 7.792368e-03 | 2.108 |
| R-HSA-202403 | TCR signaling | 7.589160e-03 | 2.120 |
| R-HSA-5654738 | Signaling by FGFR2 | 1.171113e-02 | 1.931 |
| R-HSA-6806834 | Signaling by MET | 1.171113e-02 | 1.931 |
| R-HSA-5357801 | Programmed Cell Death | 7.372051e-03 | 2.132 |
| R-HSA-9679506 | SARS-CoV Infections | 1.231881e-02 | 1.909 |
| R-HSA-1236394 | Signaling by ERBB4 | 9.236010e-03 | 2.035 |
| R-HSA-917937 | Iron uptake and transport | 9.622292e-03 | 2.017 |
| R-HSA-8939211 | ESR-mediated signaling | 1.445443e-02 | 1.840 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 1.457666e-02 | 1.836 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 1.457666e-02 | 1.836 |
| R-HSA-2559583 | Cellular Senescence | 1.469009e-02 | 1.833 |
| R-HSA-157118 | Signaling by NOTCH | 1.530468e-02 | 1.815 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 1.546957e-02 | 1.811 |
| R-HSA-70268 | Pyruvate metabolism | 1.562187e-02 | 1.806 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 1.602018e-02 | 1.795 |
| R-HSA-156902 | Peptide chain elongation | 1.616172e-02 | 1.792 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 1.682453e-02 | 1.774 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 1.682453e-02 | 1.774 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 1.703142e-02 | 1.769 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 1.703142e-02 | 1.769 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 1.785109e-02 | 1.748 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.843771e-02 | 1.734 |
| R-HSA-70263 | Gluconeogenesis | 1.850012e-02 | 1.733 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 1.865742e-02 | 1.729 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 1.903620e-02 | 1.720 |
| R-HSA-68877 | Mitotic Prometaphase | 1.938018e-02 | 1.713 |
| R-HSA-5657560 | Hereditary fructose intolerance | 1.955536e-02 | 1.709 |
| R-HSA-169131 | Inhibition of PKR | 1.955536e-02 | 1.709 |
| R-HSA-5688426 | Deubiquitination | 2.009650e-02 | 1.697 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 2.034618e-02 | 1.692 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 2.042824e-02 | 1.690 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 2.090343e-02 | 1.680 |
| R-HSA-1632852 | Macroautophagy | 2.092566e-02 | 1.679 |
| R-HSA-3371571 | HSF1-dependent transactivation | 2.118121e-02 | 1.674 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 2.154996e-02 | 1.667 |
| R-HSA-72764 | Eukaryotic Translation Termination | 2.154996e-02 | 1.667 |
| R-HSA-164378 | PKA activation in glucagon signalling | 2.209632e-02 | 1.656 |
| R-HSA-389948 | Co-inhibition by PD-1 | 2.228736e-02 | 1.652 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 2.299279e-02 | 1.638 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.308066e-02 | 1.637 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 2.316184e-02 | 1.635 |
| R-HSA-422356 | Regulation of insulin secretion | 2.356260e-02 | 1.628 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 2.356260e-02 | 1.628 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 2.356260e-02 | 1.628 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 2.356260e-02 | 1.628 |
| R-HSA-190236 | Signaling by FGFR | 2.356260e-02 | 1.628 |
| R-HSA-392851 | Prostacyclin signalling through prostacyclin receptor | 2.390648e-02 | 1.621 |
| R-HSA-72649 | Translation initiation complex formation | 2.406401e-02 | 1.619 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.406401e-02 | 1.619 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 2.496574e-02 | 1.603 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 2.518801e-02 | 1.599 |
| R-HSA-2408557 | Selenocysteine synthesis | 2.568585e-02 | 1.590 |
| R-HSA-373753 | Nephrin family interactions | 2.577533e-02 | 1.589 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.609794e-02 | 1.583 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.641837e-02 | 1.578 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 2.714846e-02 | 1.566 |
| R-HSA-192823 | Viral mRNA Translation | 2.716335e-02 | 1.566 |
| R-HSA-372790 | Signaling by GPCR | 2.783225e-02 | 1.555 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 2.792081e-02 | 1.554 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 2.792081e-02 | 1.554 |
| R-HSA-9609507 | Protein localization | 2.811576e-02 | 1.551 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.822133e-02 | 1.549 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 2.844038e-02 | 1.546 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 2.919006e-02 | 1.535 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.931650e-02 | 1.533 |
| R-HSA-191859 | snRNP Assembly | 2.931650e-02 | 1.533 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 2.947332e-02 | 1.531 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 2.968389e-02 | 1.527 |
| R-HSA-1643685 | Disease | 2.982416e-02 | 1.525 |
| R-HSA-9612973 | Autophagy | 2.997200e-02 | 1.523 |
| R-HSA-5663205 | Infectious disease | 3.027470e-02 | 1.519 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.107614e-02 | 1.508 |
| R-HSA-211000 | Gene Silencing by RNA | 3.107614e-02 | 1.508 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 3.125148e-02 | 1.505 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 3.157358e-02 | 1.501 |
| R-HSA-112043 | PLC beta mediated events | 3.157358e-02 | 1.501 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 3.189648e-02 | 1.496 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 3.189648e-02 | 1.496 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 3.189648e-02 | 1.496 |
| R-HSA-2672351 | Stimuli-sensing channels | 3.189648e-02 | 1.496 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 3.272947e-02 | 1.485 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 3.272947e-02 | 1.485 |
| R-HSA-6784531 | tRNA processing in the nucleus | 3.273539e-02 | 1.485 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 3.357513e-02 | 1.474 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 3.357513e-02 | 1.474 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 3.391929e-02 | 1.470 |
| R-HSA-2408522 | Selenoamino acid metabolism | 3.529388e-02 | 1.452 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 3.530452e-02 | 1.452 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 3.530452e-02 | 1.452 |
| R-HSA-1483249 | Inositol phosphate metabolism | 3.530452e-02 | 1.452 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 3.618829e-02 | 1.441 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 3.778559e-02 | 1.423 |
| R-HSA-9839394 | TGFBR3 expression | 3.814889e-02 | 1.419 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 3.891599e-02 | 1.410 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 4.039294e-02 | 1.394 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 4.039294e-02 | 1.394 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 4.039294e-02 | 1.394 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 4.079819e-02 | 1.389 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 4.079819e-02 | 1.389 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 4.116628e-02 | 1.385 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 4.268572e-02 | 1.370 |
| R-HSA-5689880 | Ub-specific processing proteases | 4.272152e-02 | 1.369 |
| R-HSA-68875 | Mitotic Prophase | 4.471565e-02 | 1.350 |
| R-HSA-4086398 | Ca2+ pathway | 4.695666e-02 | 1.328 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 4.741285e-02 | 1.324 |
| R-HSA-420092 | Glucagon-type ligand receptors | 4.741285e-02 | 1.324 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 4.984494e-02 | 1.302 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 4.984494e-02 | 1.302 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 5.102559e-02 | 1.292 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 5.128404e-02 | 1.290 |
| R-HSA-399719 | Trafficking of AMPA receptors | 5.232122e-02 | 1.281 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 5.276815e-02 | 1.278 |
| R-HSA-74160 | Gene expression (Transcription) | 5.398307e-02 | 1.268 |
| R-HSA-73864 | RNA Polymerase I Transcription | 5.427286e-02 | 1.265 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 5.484060e-02 | 1.261 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 5.484060e-02 | 1.261 |
| R-HSA-422475 | Axon guidance | 5.517815e-02 | 1.258 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 5.579804e-02 | 1.253 |
| R-HSA-983712 | Ion channel transport | 5.643226e-02 | 1.248 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 5.716559e-02 | 1.243 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 5.734357e-02 | 1.242 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 5.734357e-02 | 1.242 |
| R-HSA-354192 | Integrin signaling | 5.740202e-02 | 1.241 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 5.740202e-02 | 1.241 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 5.740202e-02 | 1.241 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 5.740202e-02 | 1.241 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 5.740202e-02 | 1.241 |
| R-HSA-9754119 | Drug-mediated inhibition of CDK4/CDK6 activity | 5.753327e-02 | 1.240 |
| R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... | 5.753327e-02 | 1.240 |
| R-HSA-168898 | Toll-like Receptor Cascades | 5.830531e-02 | 1.234 |
| R-HSA-163359 | Glucagon signaling in metabolic regulation | 6.000440e-02 | 1.222 |
| R-HSA-9824446 | Viral Infection Pathways | 6.194594e-02 | 1.208 |
| R-HSA-5673000 | RAF activation | 6.264672e-02 | 1.203 |
| R-HSA-163685 | Integration of energy metabolism | 6.609077e-02 | 1.180 |
| R-HSA-68911 | G2 Phase | 6.679705e-02 | 1.175 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 6.679705e-02 | 1.175 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 6.679705e-02 | 1.175 |
| R-HSA-111933 | Calmodulin induced events | 6.804707e-02 | 1.167 |
| R-HSA-111997 | CaM pathway | 6.804707e-02 | 1.167 |
| R-HSA-3371511 | HSF1 activation | 6.804707e-02 | 1.167 |
| R-HSA-69205 | G1/S-Specific Transcription | 6.804707e-02 | 1.167 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 7.028498e-02 | 1.153 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 7.080310e-02 | 1.150 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 7.562392e-02 | 1.121 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 7.597035e-02 | 1.119 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 7.597035e-02 | 1.119 |
| R-HSA-176417 | Phosphorylation of Emi1 | 7.597035e-02 | 1.119 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 7.597035e-02 | 1.119 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 7.642199e-02 | 1.117 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 7.643074e-02 | 1.117 |
| R-HSA-9675108 | Nervous system development | 7.688660e-02 | 1.114 |
| R-HSA-72766 | Translation | 7.909553e-02 | 1.102 |
| R-HSA-9658195 | Leishmania infection | 7.923048e-02 | 1.101 |
| R-HSA-9824443 | Parasitic Infection Pathways | 7.923048e-02 | 1.101 |
| R-HSA-3371568 | Attenuation phase | 7.928294e-02 | 1.101 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 8.217697e-02 | 1.085 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 8.237213e-02 | 1.084 |
| R-HSA-426486 | Small interfering RNA (siRNA) biogenesis | 8.505404e-02 | 1.070 |
| R-HSA-69478 | G2/M DNA replication checkpoint | 8.505404e-02 | 1.070 |
| R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation | 8.505404e-02 | 1.070 |
| R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 8.505404e-02 | 1.070 |
| R-HSA-8964011 | HDL clearance | 8.505404e-02 | 1.070 |
| R-HSA-391906 | Leukotriene receptors | 8.505404e-02 | 1.070 |
| R-HSA-5674135 | MAP2K and MAPK activation | 8.510318e-02 | 1.070 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 8.510318e-02 | 1.070 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 8.610599e-02 | 1.065 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 8.806066e-02 | 1.055 |
| R-HSA-114516 | Disinhibition of SNARE formation | 9.404898e-02 | 1.027 |
| R-HSA-8849473 | PTK6 Expression | 9.404898e-02 | 1.027 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 9.422825e-02 | 1.026 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 9.711193e-02 | 1.013 |
| R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | 9.711193e-02 | 1.013 |
| R-HSA-1489509 | DAG and IP3 signaling | 9.711193e-02 | 1.013 |
| R-HSA-9711097 | Cellular response to starvation | 9.785616e-02 | 1.009 |
| R-HSA-9839373 | Signaling by TGFBR3 | 1.001858e-01 | 0.999 |
| R-HSA-75153 | Apoptotic execution phase | 1.001858e-01 | 0.999 |
| R-HSA-111995 | phospho-PLA2 pathway | 1.029560e-01 | 0.987 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 1.029560e-01 | 0.987 |
| R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands | 1.029560e-01 | 0.987 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 1.029560e-01 | 0.987 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 1.029560e-01 | 0.987 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 1.061920e-01 | 0.974 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 1.064135e-01 | 0.973 |
| R-HSA-1433617 | Regulation of signaling by NODAL | 1.117761e-01 | 0.952 |
| R-HSA-2465910 | MASTL Facilitates Mitotic Progression | 1.117761e-01 | 0.952 |
| R-HSA-9762293 | Regulation of CDH11 gene transcription | 1.117761e-01 | 0.952 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 1.117761e-01 | 0.952 |
| R-HSA-418346 | Platelet homeostasis | 1.123868e-01 | 0.949 |
| R-HSA-912446 | Meiotic recombination | 1.159433e-01 | 0.936 |
| R-HSA-72187 | mRNA 3'-end processing | 1.191670e-01 | 0.924 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.191670e-01 | 0.924 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 1.205099e-01 | 0.919 |
| R-HSA-9683686 | Maturation of spike protein | 1.205099e-01 | 0.919 |
| R-HSA-110056 | MAPK3 (ERK1) activation | 1.205099e-01 | 0.919 |
| R-HSA-9764790 | Positive Regulation of CDH1 Gene Transcription | 1.205099e-01 | 0.919 |
| R-HSA-445355 | Smooth Muscle Contraction | 1.224129e-01 | 0.912 |
| R-HSA-112315 | Transmission across Chemical Synapses | 1.255974e-01 | 0.901 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 1.289685e-01 | 0.890 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 1.291585e-01 | 0.889 |
| R-HSA-9635465 | Suppression of apoptosis | 1.291585e-01 | 0.889 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 1.295527e-01 | 0.888 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.317610e-01 | 0.880 |
| R-HSA-193648 | NRAGE signals death through JNK | 1.322768e-01 | 0.879 |
| R-HSA-2514853 | Condensation of Prometaphase Chromosomes | 1.377224e-01 | 0.861 |
| R-HSA-9845323 | Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) | 1.456968e-01 | 0.837 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 1.462027e-01 | 0.835 |
| R-HSA-879415 | Advanced glycosylation endproduct receptor signaling | 1.462027e-01 | 0.835 |
| R-HSA-8983711 | OAS antiviral response | 1.462027e-01 | 0.835 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 1.490951e-01 | 0.827 |
| R-HSA-445717 | Aquaporin-mediated transport | 1.490951e-01 | 0.827 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 1.503716e-01 | 0.823 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 1.546002e-01 | 0.811 |
| R-HSA-9933947 | Formation of the non-canonical BAF (ncBAF) complex | 1.546002e-01 | 0.811 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 1.546002e-01 | 0.811 |
| R-HSA-9818030 | NFE2L2 regulating tumorigenic genes | 1.546002e-01 | 0.811 |
| R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization | 1.546002e-01 | 0.811 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 1.559391e-01 | 0.807 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 1.559391e-01 | 0.807 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 1.608157e-01 | 0.794 |
| R-HSA-1266738 | Developmental Biology | 1.617742e-01 | 0.791 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 1.629155e-01 | 0.788 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 1.629155e-01 | 0.788 |
| R-HSA-1483115 | Hydrolysis of LPC | 1.629155e-01 | 0.788 |
| R-HSA-9856872 | Malate-aspartate shuttle | 1.629155e-01 | 0.788 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 1.629155e-01 | 0.788 |
| R-HSA-9609690 | HCMV Early Events | 1.645739e-01 | 0.784 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 1.663143e-01 | 0.779 |
| R-HSA-1280218 | Adaptive Immune System | 1.704189e-01 | 0.768 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 1.711496e-01 | 0.767 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 1.711496e-01 | 0.767 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 1.711496e-01 | 0.767 |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | 1.711496e-01 | 0.767 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 1.768059e-01 | 0.753 |
| R-HSA-73857 | RNA Polymerase II Transcription | 1.779223e-01 | 0.750 |
| R-HSA-9843745 | Adipogenesis | 1.784488e-01 | 0.748 |
| R-HSA-2485179 | Activation of the phototransduction cascade | 1.793031e-01 | 0.746 |
| R-HSA-176412 | Phosphorylation of the APC/C | 1.793031e-01 | 0.746 |
| R-HSA-70350 | Fructose catabolism | 1.793031e-01 | 0.746 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 1.793031e-01 | 0.746 |
| R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | 1.793031e-01 | 0.746 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.793031e-01 | 0.746 |
| R-HSA-72172 | mRNA Splicing | 1.818675e-01 | 0.740 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 1.838574e-01 | 0.736 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 1.873770e-01 | 0.727 |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | 1.873770e-01 | 0.727 |
| R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anapha... | 1.873770e-01 | 0.727 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 1.873770e-01 | 0.727 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 1.909493e-01 | 0.719 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.953719e-01 | 0.709 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 1.953719e-01 | 0.709 |
| R-HSA-380287 | Centrosome maturation | 1.980775e-01 | 0.703 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 2.032887e-01 | 0.692 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 2.032887e-01 | 0.692 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 2.032887e-01 | 0.692 |
| R-HSA-432142 | Platelet sensitization by LDL | 2.032887e-01 | 0.692 |
| R-HSA-416482 | G alpha (12/13) signalling events | 2.088288e-01 | 0.680 |
| R-HSA-112316 | Neuronal System | 2.106006e-01 | 0.677 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 2.111280e-01 | 0.675 |
| R-HSA-429958 | mRNA decay by 3' to 5' exoribonuclease | 2.111280e-01 | 0.675 |
| R-HSA-113510 | E2F mediated regulation of DNA replication | 2.111280e-01 | 0.675 |
| R-HSA-9833482 | PKR-mediated signaling | 2.160299e-01 | 0.665 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 2.160299e-01 | 0.665 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 2.188907e-01 | 0.660 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 2.188907e-01 | 0.660 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 2.188907e-01 | 0.660 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.188907e-01 | 0.660 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 2.188907e-01 | 0.660 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 2.188907e-01 | 0.660 |
| R-HSA-1181150 | Signaling by NODAL | 2.188907e-01 | 0.660 |
| R-HSA-1482922 | Acyl chain remodelling of PI | 2.188907e-01 | 0.660 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 2.188907e-01 | 0.660 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 2.188907e-01 | 0.660 |
| R-HSA-597592 | Post-translational protein modification | 2.205076e-01 | 0.657 |
| R-HSA-9824439 | Bacterial Infection Pathways | 2.220775e-01 | 0.653 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 2.265775e-01 | 0.645 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 2.265775e-01 | 0.645 |
| R-HSA-1482925 | Acyl chain remodelling of PG | 2.265775e-01 | 0.645 |
| R-HSA-1500620 | Meiosis | 2.341234e-01 | 0.631 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 2.341891e-01 | 0.630 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 2.341891e-01 | 0.630 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 2.341891e-01 | 0.630 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 2.341891e-01 | 0.630 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 2.341891e-01 | 0.630 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 2.413879e-01 | 0.617 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 2.413879e-01 | 0.617 |
| R-HSA-5652084 | Fructose metabolism | 2.417263e-01 | 0.617 |
| R-HSA-112409 | RAF-independent MAPK1/3 activation | 2.417263e-01 | 0.617 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 2.417263e-01 | 0.617 |
| R-HSA-1989781 | PPARA activates gene expression | 2.445198e-01 | 0.612 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 2.486628e-01 | 0.604 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 2.491897e-01 | 0.603 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 2.491897e-01 | 0.603 |
| R-HSA-1855167 | Synthesis of pyrophosphates in the cytosol | 2.491897e-01 | 0.603 |
| R-HSA-3000170 | Syndecan interactions | 2.491897e-01 | 0.603 |
| R-HSA-9610379 | HCMV Late Events | 2.497712e-01 | 0.602 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 2.497712e-01 | 0.602 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 2.521224e-01 | 0.598 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 2.559451e-01 | 0.592 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 2.559451e-01 | 0.592 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 2.565802e-01 | 0.591 |
| R-HSA-429947 | Deadenylation of mRNA | 2.565802e-01 | 0.591 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 2.565802e-01 | 0.591 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 2.595880e-01 | 0.586 |
| R-HSA-381070 | IRE1alpha activates chaperones | 2.632315e-01 | 0.580 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 2.638983e-01 | 0.579 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 2.638983e-01 | 0.579 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 2.638983e-01 | 0.579 |
| R-HSA-9620244 | Long-term potentiation | 2.638983e-01 | 0.579 |
| R-HSA-203927 | MicroRNA (miRNA) biogenesis | 2.638983e-01 | 0.579 |
| R-HSA-420029 | Tight junction interactions | 2.638983e-01 | 0.579 |
| R-HSA-1482801 | Acyl chain remodelling of PS | 2.638983e-01 | 0.579 |
| R-HSA-9837999 | Mitochondrial protein degradation | 2.741628e-01 | 0.562 |
| R-HSA-5619102 | SLC transporter disorders | 2.762601e-01 | 0.559 |
| R-HSA-9609646 | HCMV Infection | 2.777898e-01 | 0.556 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 2.850877e-01 | 0.545 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 2.854260e-01 | 0.545 |
| R-HSA-171319 | Telomere Extension By Telomerase | 2.854260e-01 | 0.545 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 2.858306e-01 | 0.544 |
| R-HSA-72306 | tRNA processing | 2.869399e-01 | 0.542 |
| R-HSA-212436 | Generic Transcription Pathway | 2.906278e-01 | 0.537 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 2.924620e-01 | 0.534 |
| R-HSA-9614085 | FOXO-mediated transcription | 2.959972e-01 | 0.529 |
| R-HSA-68962 | Activation of the pre-replicative complex | 2.994291e-01 | 0.524 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 3.068831e-01 | 0.513 |
| R-HSA-449147 | Signaling by Interleukins | 3.076925e-01 | 0.512 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 3.131594e-01 | 0.504 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 3.199239e-01 | 0.495 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 3.199239e-01 | 0.495 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 3.199239e-01 | 0.495 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 3.199239e-01 | 0.495 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 3.199239e-01 | 0.495 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 3.199239e-01 | 0.495 |
| R-HSA-6804758 | Regulation of TP53 Activity through Acetylation | 3.199239e-01 | 0.495 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 3.266223e-01 | 0.486 |
| R-HSA-1482788 | Acyl chain remodelling of PC | 3.266223e-01 | 0.486 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 3.266223e-01 | 0.486 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 3.332550e-01 | 0.477 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 3.332550e-01 | 0.477 |
| R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | 3.332550e-01 | 0.477 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 3.332550e-01 | 0.477 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 3.398229e-01 | 0.469 |
| R-HSA-1482839 | Acyl chain remodelling of PE | 3.398229e-01 | 0.469 |
| R-HSA-5617833 | Cilium Assembly | 3.406558e-01 | 0.468 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 3.463264e-01 | 0.461 |
| R-HSA-8853659 | RET signaling | 3.463264e-01 | 0.461 |
| R-HSA-196757 | Metabolism of folate and pterines | 3.527663e-01 | 0.453 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.591431e-01 | 0.445 |
| R-HSA-392499 | Metabolism of proteins | 3.607468e-01 | 0.443 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 3.654575e-01 | 0.437 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 3.654575e-01 | 0.437 |
| R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | 3.654575e-01 | 0.437 |
| R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 3.717101e-01 | 0.430 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 3.717101e-01 | 0.430 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 3.717101e-01 | 0.430 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 3.717101e-01 | 0.430 |
| R-HSA-5260271 | Diseases of Immune System | 3.717101e-01 | 0.430 |
| R-HSA-379726 | Mitochondrial tRNA aminoacylation | 3.717101e-01 | 0.430 |
| R-HSA-9694548 | Maturation of spike protein | 3.779014e-01 | 0.423 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 3.840321e-01 | 0.416 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 3.840321e-01 | 0.416 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 3.901028e-01 | 0.409 |
| R-HSA-400508 | Incretin synthesis, secretion, and inactivation | 3.901028e-01 | 0.409 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 3.922666e-01 | 0.406 |
| R-HSA-397014 | Muscle contraction | 4.020656e-01 | 0.396 |
| R-HSA-9907900 | Proteasome assembly | 4.020664e-01 | 0.396 |
| R-HSA-3214858 | RMTs methylate histone arginines | 4.020664e-01 | 0.396 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 4.079604e-01 | 0.389 |
| R-HSA-9824272 | Somitogenesis | 4.079604e-01 | 0.389 |
| R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | 4.137967e-01 | 0.383 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 4.137967e-01 | 0.383 |
| R-HSA-9675135 | Diseases of DNA repair | 4.137967e-01 | 0.383 |
| R-HSA-437239 | Recycling pathway of L1 | 4.195758e-01 | 0.377 |
| R-HSA-1474165 | Reproduction | 4.231256e-01 | 0.374 |
| R-HSA-5620924 | Intraflagellar transport | 4.252983e-01 | 0.371 |
| R-HSA-9725371 | Nuclear events stimulated by ALK signaling in cancer | 4.252983e-01 | 0.371 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 4.298754e-01 | 0.367 |
| R-HSA-8957322 | Metabolism of steroids | 4.418407e-01 | 0.355 |
| R-HSA-2514856 | The phototransduction cascade | 4.421316e-01 | 0.354 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 4.465662e-01 | 0.350 |
| R-HSA-6794361 | Neurexins and neuroligins | 4.476330e-01 | 0.349 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 4.476330e-01 | 0.349 |
| R-HSA-5668914 | Diseases of metabolism | 4.544607e-01 | 0.343 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 4.564503e-01 | 0.341 |
| R-HSA-3247509 | Chromatin modifying enzymes | 4.592655e-01 | 0.338 |
| R-HSA-3214815 | HDACs deacetylate histones | 4.638161e-01 | 0.334 |
| R-HSA-5578775 | Ion homeostasis | 4.691050e-01 | 0.329 |
| R-HSA-1483166 | Synthesis of PA | 4.743421e-01 | 0.324 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 4.795279e-01 | 0.319 |
| R-HSA-180786 | Extension of Telomeres | 4.846628e-01 | 0.315 |
| R-HSA-379724 | tRNA Aminoacylation | 4.897474e-01 | 0.310 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 4.897474e-01 | 0.310 |
| R-HSA-351202 | Metabolism of polyamines | 4.897474e-01 | 0.310 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 4.947821e-01 | 0.306 |
| R-HSA-4839726 | Chromatin organization | 4.969272e-01 | 0.304 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 4.997675e-01 | 0.301 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 4.997675e-01 | 0.301 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 5.011978e-01 | 0.300 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 5.047039e-01 | 0.297 |
| R-HSA-373755 | Semaphorin interactions | 5.047039e-01 | 0.297 |
| R-HSA-936837 | Ion transport by P-type ATPases | 5.095920e-01 | 0.293 |
| R-HSA-196807 | Nicotinate metabolism | 5.239704e-01 | 0.281 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 5.286694e-01 | 0.277 |
| R-HSA-9734767 | Developmental Cell Lineages | 5.308742e-01 | 0.275 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 5.379298e-01 | 0.269 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 5.379298e-01 | 0.269 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 5.424919e-01 | 0.266 |
| R-HSA-1226099 | Signaling by FGFR in disease | 5.559115e-01 | 0.255 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 5.602971e-01 | 0.252 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 5.602971e-01 | 0.252 |
| R-HSA-216083 | Integrin cell surface interactions | 5.731976e-01 | 0.242 |
| R-HSA-191273 | Cholesterol biosynthesis | 5.731976e-01 | 0.242 |
| R-HSA-168256 | Immune System | 5.807424e-01 | 0.236 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 6.018546e-01 | 0.221 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 6.066900e-01 | 0.217 |
| R-HSA-438064 | Post NMDA receptor activation events | 6.135430e-01 | 0.212 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 6.179510e-01 | 0.209 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 6.285988e-01 | 0.202 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 6.381476e-01 | 0.195 |
| R-HSA-199991 | Membrane Trafficking | 6.509712e-01 | 0.186 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 6.535570e-01 | 0.185 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 6.547622e-01 | 0.184 |
| R-HSA-157579 | Telomere Maintenance | 6.569837e-01 | 0.182 |
| R-HSA-382551 | Transport of small molecules | 6.621087e-01 | 0.179 |
| R-HSA-3214847 | HATs acetylate histones | 6.637363e-01 | 0.178 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 6.736184e-01 | 0.172 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 6.832118e-01 | 0.165 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 6.832118e-01 | 0.165 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 6.955685e-01 | 0.158 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 7.064911e-01 | 0.151 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 7.085737e-01 | 0.150 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 7.103429e-01 | 0.149 |
| R-HSA-5653656 | Vesicle-mediated transport | 7.154852e-01 | 0.145 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 7.188632e-01 | 0.143 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 7.216475e-01 | 0.142 |
| R-HSA-373760 | L1CAM interactions | 7.244045e-01 | 0.140 |
| R-HSA-2980736 | Peptide hormone metabolism | 7.271344e-01 | 0.138 |
| R-HSA-73886 | Chromosome Maintenance | 7.377876e-01 | 0.132 |
| R-HSA-9717207 | Sensory perception of sweet, bitter, and umami (glutamate) taste | 7.429582e-01 | 0.129 |
| R-HSA-2132295 | MHC class II antigen presentation | 7.429582e-01 | 0.129 |
| R-HSA-6809371 | Formation of the cornified envelope | 7.455053e-01 | 0.128 |
| R-HSA-194138 | Signaling by VEGF | 7.505247e-01 | 0.125 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 7.537926e-01 | 0.123 |
| R-HSA-9717189 | Sensory perception of taste | 7.673300e-01 | 0.115 |
| R-HSA-5576891 | Cardiac conduction | 7.673300e-01 | 0.115 |
| R-HSA-416476 | G alpha (q) signalling events | 7.723551e-01 | 0.112 |
| R-HSA-2187338 | Visual phototransduction | 8.055546e-01 | 0.094 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 8.055546e-01 | 0.094 |
| R-HSA-9758941 | Gastrulation | 8.093960e-01 | 0.092 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 8.112884e-01 | 0.091 |
| R-HSA-9679191 | Potential therapeutics for SARS | 8.112884e-01 | 0.091 |
| R-HSA-2142753 | Arachidonate metabolism | 8.150172e-01 | 0.089 |
| R-HSA-877300 | Interferon gamma signaling | 8.275008e-01 | 0.082 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 8.544413e-01 | 0.068 |
| R-HSA-500792 | GPCR ligand binding | 8.559547e-01 | 0.068 |
| R-HSA-611105 | Respiratory electron transport | 8.587412e-01 | 0.066 |
| R-HSA-1474244 | Extracellular matrix organization | 8.633727e-01 | 0.064 |
| R-HSA-375276 | Peptide ligand-binding receptors | 8.696004e-01 | 0.061 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 8.888920e-01 | 0.051 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 8.899988e-01 | 0.051 |
| R-HSA-6805567 | Keratinization | 8.943176e-01 | 0.049 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 8.947611e-01 | 0.048 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 9.180449e-01 | 0.037 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 9.225459e-01 | 0.035 |
| R-HSA-6798695 | Neutrophil degranulation | 9.513136e-01 | 0.022 |
| R-HSA-1483257 | Phospholipid metabolism | 9.567654e-01 | 0.019 |
| R-HSA-168249 | Innate Immune System | 9.609348e-01 | 0.017 |
| R-HSA-1430728 | Metabolism | 9.802054e-01 | 0.009 |
| R-HSA-8978868 | Fatty acid metabolism | 9.862019e-01 | 0.006 |
| R-HSA-556833 | Metabolism of lipids | 9.993886e-01 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 9.999650e-01 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.813 | 0.013 | 1 | 0.807 |
ALPHAK3 |
0.812 | 0.147 | -1 | 0.755 |
MST2 |
0.809 | 0.057 | 1 | 0.801 |
TAK1 |
0.808 | -0.039 | 1 | 0.810 |
EEF2K |
0.808 | 0.069 | 3 | 0.877 |
TNIK |
0.807 | 0.058 | 3 | 0.903 |
PKR |
0.807 | 0.035 | 1 | 0.831 |
GCK |
0.806 | 0.030 | 1 | 0.775 |
MINK |
0.805 | 0.014 | 1 | 0.775 |
OSR1 |
0.805 | 0.058 | 2 | 0.617 |
MEKK2 |
0.804 | 0.027 | 2 | 0.635 |
MOS |
0.804 | 0.252 | 1 | 0.887 |
VRK1 |
0.802 | -0.093 | 2 | 0.670 |
VRK2 |
0.801 | -0.173 | 1 | 0.848 |
BRAF |
0.800 | -0.017 | -4 | 0.763 |
TAO3 |
0.800 | 0.063 | 1 | 0.764 |
TTK |
0.799 | 0.000 | -2 | 0.728 |
MST1 |
0.799 | -0.036 | 1 | 0.780 |
LRRK2 |
0.798 | -0.131 | 2 | 0.654 |
MYO3A |
0.797 | -0.001 | 1 | 0.775 |
KHS2 |
0.797 | 0.023 | 1 | 0.771 |
HGK |
0.796 | -0.013 | 3 | 0.878 |
KHS1 |
0.796 | -0.007 | 1 | 0.766 |
MPSK1 |
0.796 | 0.110 | 1 | 0.754 |
TAO2 |
0.796 | -0.045 | 2 | 0.680 |
MEK1 |
0.796 | -0.092 | 2 | 0.661 |
BMPR2 |
0.795 | 0.004 | -2 | 0.800 |
MEKK1 |
0.793 | -0.029 | 1 | 0.807 |
MEK5 |
0.792 | -0.163 | 2 | 0.642 |
LATS1 |
0.792 | 0.084 | -3 | 0.744 |
MYO3B |
0.792 | -0.035 | 2 | 0.638 |
ALK2 |
0.792 | 0.088 | -2 | 0.714 |
PRP4 |
0.791 | 0.106 | -3 | 0.785 |
MST3 |
0.791 | -0.029 | 2 | 0.660 |
BMPR1B |
0.791 | 0.130 | 1 | 0.792 |
NEK5 |
0.790 | -0.124 | 1 | 0.809 |
ASK1 |
0.790 | -0.142 | 1 | 0.718 |
MAP3K15 |
0.790 | -0.089 | 1 | 0.729 |
HPK1 |
0.789 | -0.061 | 1 | 0.762 |
NEK1 |
0.789 | -0.178 | 1 | 0.782 |
MEKK3 |
0.789 | -0.035 | 1 | 0.778 |
PRPK |
0.789 | 0.011 | -1 | 0.812 |
CAMKK1 |
0.788 | -0.131 | -2 | 0.693 |
DLK |
0.788 | -0.058 | 1 | 0.806 |
PDK1 |
0.788 | -0.127 | 1 | 0.752 |
NIK |
0.787 | -0.136 | -3 | 0.748 |
ALK4 |
0.786 | -0.035 | -2 | 0.724 |
GRK7 |
0.786 | 0.155 | 1 | 0.739 |
COT |
0.786 | 0.248 | 2 | 0.718 |
LKB1 |
0.786 | -0.147 | -3 | 0.740 |
ACVR2B |
0.786 | 0.083 | -2 | 0.711 |
CAMKK2 |
0.786 | -0.163 | -2 | 0.692 |
YSK4 |
0.786 | -0.050 | 1 | 0.748 |
PASK |
0.785 | 0.007 | -3 | 0.736 |
TGFBR1 |
0.785 | 0.057 | -2 | 0.697 |
STLK3 |
0.785 | -0.124 | 1 | 0.741 |
ATR |
0.784 | 0.052 | 1 | 0.832 |
CDKL1 |
0.784 | 0.068 | -3 | 0.669 |
MLK1 |
0.784 | 0.087 | 2 | 0.663 |
NEK8 |
0.784 | -0.133 | 2 | 0.634 |
YSK1 |
0.783 | -0.097 | 2 | 0.635 |
BIKE |
0.782 | -0.041 | 1 | 0.684 |
MLK2 |
0.782 | -0.023 | 2 | 0.655 |
ACVR2A |
0.782 | 0.055 | -2 | 0.691 |
MEKK6 |
0.782 | -0.155 | 1 | 0.766 |
ANKRD3 |
0.782 | -0.145 | 1 | 0.836 |
ZAK |
0.782 | -0.074 | 1 | 0.757 |
MEK2 |
0.781 | -0.192 | 2 | 0.625 |
ICK |
0.781 | 0.095 | -3 | 0.703 |
BMPR1A |
0.781 | 0.116 | 1 | 0.779 |
DAPK2 |
0.781 | -0.138 | -3 | 0.732 |
MLK4 |
0.781 | 0.117 | 2 | 0.597 |
CAMLCK |
0.780 | -0.104 | -2 | 0.758 |
MLK3 |
0.779 | 0.110 | 2 | 0.612 |
CLK3 |
0.778 | 0.202 | 1 | 0.785 |
CHAK2 |
0.778 | 0.072 | -1 | 0.775 |
P38A |
0.778 | 0.076 | 1 | 0.632 |
P38B |
0.778 | 0.087 | 1 | 0.566 |
NEK11 |
0.778 | -0.179 | 1 | 0.760 |
JNK3 |
0.778 | 0.018 | 1 | 0.581 |
NLK |
0.777 | -0.036 | 1 | 0.772 |
NEK4 |
0.777 | -0.196 | 1 | 0.780 |
PBK |
0.777 | -0.081 | 1 | 0.736 |
RAF1 |
0.776 | -0.018 | 1 | 0.830 |
JNK2 |
0.776 | 0.022 | 1 | 0.544 |
GRK1 |
0.774 | 0.206 | -2 | 0.798 |
DSTYK |
0.773 | 0.105 | 2 | 0.756 |
LOK |
0.773 | -0.115 | -2 | 0.730 |
TLK2 |
0.772 | -0.009 | 1 | 0.805 |
PERK |
0.772 | -0.130 | -2 | 0.759 |
CAMK1B |
0.772 | -0.121 | -3 | 0.720 |
CAMK2G |
0.772 | 0.024 | 2 | 0.683 |
GRK6 |
0.772 | 0.025 | 1 | 0.832 |
CDK1 |
0.771 | 0.112 | 1 | 0.559 |
SLK |
0.771 | -0.062 | -2 | 0.707 |
CDK5 |
0.771 | 0.087 | 1 | 0.623 |
TAO1 |
0.771 | -0.069 | 1 | 0.698 |
SKMLCK |
0.770 | -0.024 | -2 | 0.776 |
ROCK2 |
0.770 | -0.076 | -3 | 0.645 |
GRK5 |
0.769 | -0.063 | -3 | 0.761 |
ERK5 |
0.769 | 0.018 | 1 | 0.758 |
AAK1 |
0.768 | -0.018 | 1 | 0.573 |
DAPK3 |
0.768 | -0.093 | -3 | 0.654 |
FAM20C |
0.767 | 0.467 | 2 | 0.833 |
MAK |
0.767 | 0.150 | -2 | 0.850 |
NEK9 |
0.767 | -0.151 | 2 | 0.658 |
PIM3 |
0.765 | 0.020 | -3 | 0.714 |
HRI |
0.765 | -0.166 | -2 | 0.773 |
PLK1 |
0.765 | -0.060 | -2 | 0.709 |
PLK2 |
0.764 | 0.169 | -3 | 0.856 |
PDHK4 |
0.764 | -0.123 | 1 | 0.827 |
P38G |
0.763 | 0.034 | 1 | 0.466 |
PKCD |
0.763 | -0.001 | 2 | 0.639 |
CDKL5 |
0.763 | 0.087 | -3 | 0.659 |
TLK1 |
0.763 | -0.106 | -2 | 0.748 |
SMMLCK |
0.762 | -0.148 | -3 | 0.664 |
DMPK1 |
0.762 | -0.099 | -3 | 0.602 |
HASPIN |
0.761 | -0.025 | -1 | 0.643 |
GSK3A |
0.761 | 0.108 | 4 | 0.564 |
CDK3 |
0.761 | 0.139 | 1 | 0.496 |
PKN3 |
0.760 | -0.049 | -3 | 0.689 |
P38D |
0.760 | 0.048 | 1 | 0.493 |
MASTL |
0.760 | -0.244 | -2 | 0.776 |
MST4 |
0.760 | 0.006 | 2 | 0.682 |
CDC7 |
0.760 | 0.032 | 1 | 0.866 |
GRK2 |
0.760 | -0.009 | -2 | 0.688 |
PINK1 |
0.760 | -0.083 | 1 | 0.787 |
ERK1 |
0.760 | 0.061 | 1 | 0.548 |
ATM |
0.760 | 0.075 | 1 | 0.783 |
PIM1 |
0.760 | -0.010 | -3 | 0.642 |
CHAK1 |
0.759 | -0.053 | 2 | 0.581 |
ERK7 |
0.759 | 0.004 | 2 | 0.454 |
TSSK2 |
0.758 | -0.073 | -5 | 0.702 |
PLK3 |
0.758 | 0.026 | 2 | 0.617 |
WNK4 |
0.758 | -0.165 | -2 | 0.803 |
NEK2 |
0.758 | -0.166 | 2 | 0.626 |
BUB1 |
0.757 | -0.026 | -5 | 0.636 |
TBK1 |
0.757 | 0.041 | 1 | 0.730 |
ERK2 |
0.757 | -0.015 | 1 | 0.592 |
CDK2 |
0.757 | 0.082 | 1 | 0.644 |
DNAPK |
0.757 | 0.043 | 1 | 0.693 |
JNK1 |
0.756 | 0.009 | 1 | 0.532 |
NEK7 |
0.756 | -0.081 | -3 | 0.742 |
IRAK4 |
0.756 | -0.158 | 1 | 0.781 |
RIPK3 |
0.755 | -0.085 | 3 | 0.687 |
WNK1 |
0.755 | -0.101 | -2 | 0.805 |
PDHK1 |
0.755 | -0.206 | 1 | 0.830 |
HIPK1 |
0.755 | -0.017 | 1 | 0.656 |
MARK4 |
0.754 | -0.045 | 4 | 0.821 |
GSK3B |
0.753 | 0.043 | 4 | 0.556 |
DAPK1 |
0.753 | -0.107 | -3 | 0.636 |
GRK4 |
0.753 | 0.025 | -2 | 0.791 |
IKKA |
0.753 | 0.134 | -2 | 0.711 |
ULK2 |
0.753 | -0.113 | 2 | 0.612 |
MOK |
0.753 | 0.055 | 1 | 0.685 |
NEK6 |
0.753 | -0.028 | -2 | 0.763 |
RIPK1 |
0.753 | -0.204 | 1 | 0.787 |
MTOR |
0.753 | -0.039 | 1 | 0.721 |
IKKE |
0.751 | 0.013 | 1 | 0.728 |
ROCK1 |
0.751 | -0.104 | -3 | 0.600 |
TGFBR2 |
0.751 | -0.074 | -2 | 0.694 |
DYRK2 |
0.750 | 0.010 | 1 | 0.645 |
IKKB |
0.750 | 0.034 | -2 | 0.708 |
CHK1 |
0.750 | -0.101 | -3 | 0.714 |
HUNK |
0.750 | -0.157 | 2 | 0.640 |
AMPKA1 |
0.749 | -0.130 | -3 | 0.713 |
DRAK1 |
0.749 | -0.122 | 1 | 0.711 |
IRE2 |
0.749 | -0.046 | 2 | 0.587 |
NEK3 |
0.749 | -0.222 | 1 | 0.731 |
CDK6 |
0.748 | 0.008 | 1 | 0.547 |
IRE1 |
0.748 | -0.072 | 1 | 0.773 |
PKN2 |
0.748 | -0.106 | -3 | 0.685 |
CDK8 |
0.747 | 0.069 | 1 | 0.595 |
SMG1 |
0.746 | -0.055 | 1 | 0.786 |
PKCZ |
0.746 | -0.070 | 2 | 0.616 |
CAMK2B |
0.746 | 0.050 | 2 | 0.708 |
PIM2 |
0.746 | -0.079 | -3 | 0.599 |
TTBK2 |
0.745 | -0.120 | 2 | 0.543 |
PKCA |
0.745 | -0.033 | 2 | 0.593 |
NUAK2 |
0.745 | -0.112 | -3 | 0.696 |
TSSK1 |
0.745 | -0.085 | -3 | 0.739 |
CK2A2 |
0.744 | 0.136 | 1 | 0.754 |
PKCB |
0.744 | -0.033 | 2 | 0.602 |
HIPK4 |
0.744 | 0.031 | 1 | 0.747 |
SRPK1 |
0.743 | 0.014 | -3 | 0.617 |
P70S6KB |
0.743 | -0.108 | -3 | 0.648 |
PKCH |
0.743 | -0.077 | 2 | 0.582 |
SRPK3 |
0.742 | -0.013 | -3 | 0.587 |
DCAMKL1 |
0.742 | -0.152 | -3 | 0.646 |
CAMK2D |
0.742 | -0.078 | -3 | 0.696 |
HIPK3 |
0.741 | -0.059 | 1 | 0.655 |
CDK4 |
0.741 | -0.015 | 1 | 0.535 |
DYRK1A |
0.741 | -0.010 | 1 | 0.670 |
WNK3 |
0.741 | -0.228 | 1 | 0.794 |
MRCKB |
0.741 | -0.109 | -3 | 0.580 |
GRK3 |
0.740 | 0.009 | -2 | 0.649 |
CDK17 |
0.740 | 0.010 | 1 | 0.474 |
CDK18 |
0.740 | 0.035 | 1 | 0.527 |
CDK16 |
0.739 | 0.023 | 1 | 0.497 |
MRCKA |
0.738 | -0.128 | -3 | 0.601 |
IRAK1 |
0.738 | -0.226 | -1 | 0.680 |
CDK14 |
0.738 | -0.043 | 1 | 0.572 |
PKCG |
0.738 | -0.048 | 2 | 0.596 |
GCN2 |
0.737 | -0.074 | 2 | 0.617 |
HIPK2 |
0.736 | 0.032 | 1 | 0.548 |
CK2A1 |
0.736 | 0.124 | 1 | 0.728 |
SGK3 |
0.736 | -0.106 | -3 | 0.619 |
ULK1 |
0.736 | -0.144 | -3 | 0.707 |
CDK13 |
0.736 | -0.022 | 1 | 0.574 |
CK1D |
0.736 | -0.009 | -3 | 0.435 |
CLK4 |
0.736 | -0.060 | -3 | 0.623 |
MARK2 |
0.735 | -0.064 | 4 | 0.719 |
PAK1 |
0.735 | -0.110 | -2 | 0.713 |
NDR1 |
0.735 | -0.104 | -3 | 0.699 |
CAMK2A |
0.735 | -0.028 | 2 | 0.677 |
PDHK3_TYR |
0.734 | 0.115 | 4 | 0.885 |
AKT2 |
0.734 | -0.076 | -3 | 0.543 |
CRIK |
0.734 | -0.115 | -3 | 0.561 |
AMPKA2 |
0.733 | -0.139 | -3 | 0.675 |
CDK19 |
0.733 | 0.068 | 1 | 0.552 |
BMPR2_TYR |
0.733 | 0.146 | -1 | 0.889 |
DCAMKL2 |
0.733 | -0.176 | -3 | 0.662 |
MYLK4 |
0.733 | -0.132 | -2 | 0.681 |
PAK2 |
0.733 | -0.163 | -2 | 0.698 |
CDK12 |
0.732 | -0.025 | 1 | 0.544 |
NDR2 |
0.731 | -0.019 | -3 | 0.720 |
PKCE |
0.731 | -0.058 | 2 | 0.586 |
RSK2 |
0.731 | -0.073 | -3 | 0.638 |
STK33 |
0.731 | -0.168 | 2 | 0.454 |
DYRK3 |
0.731 | -0.052 | 1 | 0.667 |
QIK |
0.731 | -0.178 | -3 | 0.689 |
SSTK |
0.731 | -0.106 | 4 | 0.789 |
PLK4 |
0.731 | -0.133 | 2 | 0.455 |
QSK |
0.730 | -0.084 | 4 | 0.792 |
PDHK1_TYR |
0.729 | 0.124 | -1 | 0.868 |
DYRK4 |
0.729 | -0.004 | 1 | 0.559 |
CDK7 |
0.729 | -0.021 | 1 | 0.605 |
MAP2K6_TYR |
0.729 | 0.082 | -1 | 0.850 |
TXK |
0.729 | 0.194 | 1 | 0.843 |
PDHK4_TYR |
0.729 | 0.078 | 2 | 0.685 |
DYRK1B |
0.729 | -0.052 | 1 | 0.588 |
CK1E |
0.728 | 0.008 | -3 | 0.493 |
NIM1 |
0.728 | -0.153 | 3 | 0.733 |
MARK3 |
0.728 | -0.074 | 4 | 0.755 |
MARK1 |
0.728 | -0.108 | 4 | 0.776 |
AURA |
0.728 | -0.051 | -2 | 0.514 |
RIPK2 |
0.728 | -0.265 | 1 | 0.725 |
P90RSK |
0.727 | -0.106 | -3 | 0.646 |
SGK1 |
0.727 | -0.077 | -3 | 0.474 |
PKACG |
0.727 | -0.085 | -2 | 0.685 |
EPHA6 |
0.727 | 0.121 | -1 | 0.860 |
RSK4 |
0.727 | -0.042 | -3 | 0.614 |
CK1A2 |
0.727 | -0.025 | -3 | 0.431 |
MAPKAPK3 |
0.726 | -0.131 | -3 | 0.630 |
CLK2 |
0.726 | 0.036 | -3 | 0.613 |
AURB |
0.726 | -0.095 | -2 | 0.558 |
MELK |
0.726 | -0.192 | -3 | 0.653 |
PKCI |
0.726 | -0.119 | 2 | 0.594 |
PRKD1 |
0.725 | -0.068 | -3 | 0.695 |
PAK3 |
0.725 | -0.166 | -2 | 0.705 |
CAMK4 |
0.725 | -0.219 | -3 | 0.668 |
AKT1 |
0.725 | -0.088 | -3 | 0.559 |
PKCT |
0.725 | -0.110 | 2 | 0.588 |
MAP2K4_TYR |
0.724 | -0.026 | -1 | 0.840 |
EPHB4 |
0.724 | 0.106 | -1 | 0.810 |
PKG2 |
0.723 | -0.080 | -2 | 0.606 |
BLK |
0.723 | 0.183 | -1 | 0.841 |
LCK |
0.723 | 0.174 | -1 | 0.831 |
TESK1_TYR |
0.723 | -0.072 | 3 | 0.849 |
BCKDK |
0.723 | -0.158 | -1 | 0.727 |
PRKD3 |
0.722 | -0.111 | -3 | 0.592 |
CLK1 |
0.722 | -0.051 | -3 | 0.594 |
MNK1 |
0.722 | -0.102 | -2 | 0.699 |
KIS |
0.722 | 0.058 | 1 | 0.633 |
CDK9 |
0.721 | -0.080 | 1 | 0.575 |
CHK2 |
0.721 | -0.132 | -3 | 0.486 |
CAMK1D |
0.721 | -0.130 | -3 | 0.539 |
CDK10 |
0.721 | -0.038 | 1 | 0.557 |
LATS2 |
0.721 | -0.094 | -5 | 0.626 |
SRPK2 |
0.720 | -0.009 | -3 | 0.540 |
MAP2K7_TYR |
0.720 | -0.145 | 2 | 0.675 |
MSK1 |
0.720 | -0.084 | -3 | 0.607 |
SIK |
0.720 | -0.092 | -3 | 0.611 |
PKMYT1_TYR |
0.720 | -0.098 | 3 | 0.806 |
PINK1_TYR |
0.720 | -0.050 | 1 | 0.807 |
MNK2 |
0.720 | -0.099 | -2 | 0.681 |
ABL2 |
0.719 | 0.108 | -1 | 0.763 |
MSK2 |
0.719 | -0.111 | -3 | 0.608 |
PKACB |
0.719 | -0.052 | -2 | 0.585 |
YANK3 |
0.718 | -0.075 | 2 | 0.293 |
YES1 |
0.718 | 0.093 | -1 | 0.796 |
FYN |
0.718 | 0.196 | -1 | 0.828 |
EPHA4 |
0.718 | 0.077 | 2 | 0.626 |
RSK3 |
0.717 | -0.108 | -3 | 0.638 |
CAMK1G |
0.717 | -0.161 | -3 | 0.598 |
PRKD2 |
0.717 | -0.072 | -3 | 0.628 |
HCK |
0.716 | 0.090 | -1 | 0.818 |
AURC |
0.716 | -0.067 | -2 | 0.564 |
CSF1R |
0.715 | 0.055 | 3 | 0.758 |
EPHB2 |
0.715 | 0.100 | -1 | 0.797 |
ITK |
0.715 | 0.069 | -1 | 0.768 |
MAPKAPK2 |
0.714 | -0.059 | -3 | 0.593 |
SRMS |
0.714 | 0.073 | 1 | 0.862 |
TTBK1 |
0.714 | -0.177 | 2 | 0.472 |
FER |
0.713 | 0.038 | 1 | 0.873 |
LIMK2_TYR |
0.713 | -0.105 | -3 | 0.771 |
EPHB1 |
0.712 | 0.044 | 1 | 0.853 |
YANK2 |
0.712 | -0.081 | 2 | 0.325 |
RET |
0.711 | -0.061 | 1 | 0.781 |
SYK |
0.711 | 0.166 | -1 | 0.832 |
FGR |
0.711 | -0.018 | 1 | 0.836 |
JAK2 |
0.711 | -0.046 | 1 | 0.777 |
TYK2 |
0.710 | -0.097 | 1 | 0.788 |
ROS1 |
0.710 | -0.059 | 3 | 0.746 |
ABL1 |
0.710 | 0.036 | -1 | 0.748 |
INSRR |
0.710 | 0.036 | 3 | 0.702 |
TYRO3 |
0.710 | -0.063 | 3 | 0.776 |
EPHB3 |
0.710 | 0.036 | -1 | 0.793 |
PTK2 |
0.710 | 0.140 | -1 | 0.861 |
BMX |
0.709 | 0.048 | -1 | 0.706 |
LIMK1_TYR |
0.709 | -0.171 | 2 | 0.676 |
SBK |
0.709 | -0.101 | -3 | 0.426 |
NUAK1 |
0.708 | -0.158 | -3 | 0.637 |
PHKG1 |
0.708 | -0.175 | -3 | 0.685 |
JAK3 |
0.708 | -0.025 | 1 | 0.745 |
MST1R |
0.708 | -0.109 | 3 | 0.778 |
MET |
0.707 | 0.030 | 3 | 0.741 |
LYN |
0.706 | 0.094 | 3 | 0.668 |
KIT |
0.706 | -0.006 | 3 | 0.749 |
EPHA7 |
0.705 | 0.038 | 2 | 0.622 |
EPHA8 |
0.704 | 0.094 | -1 | 0.812 |
P70S6K |
0.704 | -0.154 | -3 | 0.554 |
PKACA |
0.704 | -0.075 | -2 | 0.536 |
PRKX |
0.704 | -0.014 | -3 | 0.547 |
FLT3 |
0.704 | -0.017 | 3 | 0.770 |
FRK |
0.704 | 0.050 | -1 | 0.829 |
SNRK |
0.703 | -0.271 | 2 | 0.484 |
BTK |
0.703 | -0.010 | -1 | 0.708 |
AKT3 |
0.702 | -0.085 | -3 | 0.490 |
TEC |
0.702 | 0.001 | -1 | 0.683 |
EPHA5 |
0.702 | 0.076 | 2 | 0.624 |
TNK2 |
0.702 | -0.082 | 3 | 0.698 |
BRSK1 |
0.701 | -0.137 | -3 | 0.645 |
SRC |
0.701 | 0.072 | -1 | 0.794 |
CAMK1A |
0.701 | -0.153 | -3 | 0.500 |
FLT1 |
0.701 | -0.017 | -1 | 0.839 |
DDR1 |
0.700 | -0.160 | 4 | 0.798 |
PDGFRB |
0.700 | -0.098 | 3 | 0.771 |
KDR |
0.700 | -0.075 | 3 | 0.716 |
TNNI3K_TYR |
0.699 | -0.068 | 1 | 0.821 |
MAPKAPK5 |
0.699 | -0.174 | -3 | 0.568 |
PKN1 |
0.699 | -0.145 | -3 | 0.567 |
FGFR2 |
0.699 | -0.068 | 3 | 0.724 |
PAK6 |
0.698 | -0.107 | -2 | 0.610 |
BRSK2 |
0.698 | -0.189 | -3 | 0.663 |
EPHA3 |
0.698 | -0.043 | 2 | 0.595 |
MERTK |
0.697 | -0.039 | 3 | 0.720 |
EGFR |
0.697 | 0.034 | 1 | 0.649 |
JAK1 |
0.697 | -0.080 | 1 | 0.718 |
ERBB2 |
0.695 | -0.052 | 1 | 0.733 |
WEE1_TYR |
0.695 | -0.065 | -1 | 0.683 |
MATK |
0.694 | -0.028 | -1 | 0.690 |
CSK |
0.694 | 0.034 | 2 | 0.611 |
NTRK1 |
0.694 | -0.083 | -1 | 0.760 |
ALK |
0.693 | -0.090 | 3 | 0.682 |
EPHA2 |
0.693 | 0.054 | -1 | 0.788 |
LTK |
0.692 | -0.083 | 3 | 0.699 |
FGFR3 |
0.691 | -0.060 | 3 | 0.700 |
INSR |
0.691 | -0.054 | 3 | 0.686 |
TEK |
0.691 | -0.143 | 3 | 0.690 |
PHKG2 |
0.691 | -0.165 | -3 | 0.636 |
ERBB4 |
0.691 | 0.052 | 1 | 0.693 |
TNK1 |
0.691 | -0.152 | 3 | 0.753 |
FGFR4 |
0.690 | 0.022 | -1 | 0.738 |
FGFR1 |
0.690 | -0.136 | 3 | 0.704 |
CK1G1 |
0.690 | -0.054 | -3 | 0.483 |
PTK6 |
0.690 | -0.122 | -1 | 0.655 |
PDGFRA |
0.690 | -0.174 | 3 | 0.782 |
AXL |
0.690 | -0.128 | 3 | 0.709 |
EPHA1 |
0.690 | -0.071 | 3 | 0.724 |
NTRK3 |
0.690 | -0.051 | -1 | 0.715 |
NEK10_TYR |
0.688 | -0.161 | 1 | 0.628 |
CK1G3 |
0.687 | -0.053 | -3 | 0.308 |
PAK5 |
0.686 | -0.132 | -2 | 0.569 |
PTK2B |
0.686 | -0.065 | -1 | 0.704 |
FLT4 |
0.686 | -0.130 | 3 | 0.697 |
NTRK2 |
0.685 | -0.139 | 3 | 0.693 |
DDR2 |
0.685 | -0.055 | 3 | 0.675 |
ZAP70 |
0.684 | 0.051 | -1 | 0.740 |
CK1G2 |
0.682 | 0.001 | -3 | 0.399 |
IGF1R |
0.681 | -0.027 | 3 | 0.613 |
PAK4 |
0.677 | -0.120 | -2 | 0.561 |
PKG1 |
0.670 | -0.129 | -2 | 0.509 |
MUSK |
0.670 | -0.135 | 1 | 0.635 |
CK1A |
0.668 | -0.036 | -3 | 0.356 |
FES |
0.664 | -0.093 | -1 | 0.663 |