Motif 1043 (n=111)

Position-wise Probabilities
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uniprot genes site source protein function
A6H8Y1 BDP1 S2044 ochoa Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269|PubMed:11040218}.
A6NKT7 RGPD3 T1475 ochoa RanBP2-like and GRIP domain-containing protein 3 None
E9PAV3 NACA S1977 ochoa Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC) Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity). {ECO:0000250|UniProtKB:P70670}.
E9PMD0 None S240 ochoa Uncharacterized protein None
I3L0D1 RBAK-RBAKDN S78 ochoa HCG1647537, isoform CRA_b (RBAK-RBAKDN readthrough) None
M0QX08 None S58 ochoa Protein kinase domain-containing protein None
O00562 PITPNM1 S896 ochoa|psp Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914). {ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:10531358, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057, ECO:0000269|PubMed:22822086}.
O14715 RGPD8 T1474 ochoa RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) None
O15061 SYNM S777 ochoa Synemin (Desmuslin) Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269|PubMed:11353857, ECO:0000269|PubMed:16777071, ECO:0000269|PubMed:18028034}.
O43491 EPB41L2 S598 ochoa Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G) Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
O60291 MGRN1 S506 ochoa E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1) E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074, ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.
O60292 SIPA1L3 S326 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O60292 SIPA1L3 S1534 ochoa Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217). {ECO:0000269|PubMed:26231217}.
O75376 NCOR1 S992 ochoa Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.
O94804 STK10 S438 ochoa Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966, ECO:0000269|PubMed:19255442}.
O96019 ACTL6A S86 ochoa|psp Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K) Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250|UniProtKB:Q9Z2N8, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:29374058, ECO:0000303|PubMed:15196461, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
O96020 CCNE2 S67 ochoa G1/S-specific cyclin-E2 Essential for the control of the cell cycle at the late G1 and early S phase. {ECO:0000269|PubMed:9840927, ECO:0000269|PubMed:9840943, ECO:0000269|PubMed:9858585}.
P05455 SSB S92 ochoa Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}.
P0DJD0 RGPD1 T1459 ochoa RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) None
P0DJD1 RGPD2 T1467 ochoa RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) None
P16157 ANK1 S856 ochoa Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646, ECO:0000269|PubMed:35835865}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.
P21283 ATP6V1C1 S269 ochoa V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). {ECO:0000250|UniProtKB:P21282, ECO:0000250|UniProtKB:P31412, ECO:0000269|PubMed:33065002}.
P30876 POLR2B S106 ochoa DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48) Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity) (PubMed:27193682, PubMed:30190596, PubMed:9852112). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:27193682, PubMed:30190596, PubMed:9852112). Forms Pol II active center together with the largest subunit POLR2A/RPB1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity) (PubMed:30190596, PubMed:9852112). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity) (PubMed:8381534). {ECO:0000250|UniProtKB:A5PJW8, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:8381534, ECO:0000269|PubMed:9852112}.; FUNCTION: RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription. {ECO:0000269|PubMed:23395899}.
P36404 ARL2 S45 ochoa ADP-ribosylation factor-like protein 2 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (PubMed:10831612, PubMed:16525022, PubMed:18234692, PubMed:18588884, PubMed:20740604). Also regulates mitochondrial integrity and function (PubMed:30945270). {ECO:0000269|PubMed:10831612, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18234692, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:20740604, ECO:0000269|PubMed:30945270}.
P38432 COIL S489 ochoa|psp Coilin (p80-coilin) Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}.
P41236 PPP1R2 S130 ochoa Protein phosphatase inhibitor 2 (IPP-2) Inhibitor of protein-phosphatase 1.
P42566 EPS15 S563 ochoa Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
P46100 ATRX S656 ochoa Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX) Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610). {ECO:0000269|PubMed:12953102, ECO:0000269|PubMed:14990586, ECO:0000269|PubMed:20504901, ECO:0000269|PubMed:20651253, ECO:0000269|PubMed:21029860, ECO:0000269|PubMed:22391447, ECO:0000269|PubMed:22829774, ECO:0000269|PubMed:24500201, ECO:0000269|PubMed:27029610}.
P49792 RANBP2 T2450 ochoa E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.
P51398 DAP3 S220 psp Small ribosomal subunit protein mS29 (EC 3.6.5.-) (28S ribosomal protein S29, mitochondrial) (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) As a component of the mitochondrial small ribosomal subunit, it plays a role in the translation of mitochondrial mRNAs (PubMed:39701103). Involved in mediating interferon-gamma-induced cell death (PubMed:7499268). Displays GTPase activity in vitro (PubMed:39701103). {ECO:0000269|PubMed:39701103, ECO:0000269|PubMed:7499268}.
P51587 BRCA2 S2095 ochoa Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180). {ECO:0000269|PubMed:15115758, ECO:0000269|PubMed:15199141, ECO:0000269|PubMed:15671039, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:20729832, ECO:0000269|PubMed:20729858, ECO:0000269|PubMed:20729859, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21719596, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:24896180}.
P54727 RAD23B S160 ochoa UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58) Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.
P78527 PRKDC S1203 ochoa DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}.
Q08AM6 VAC14 S743 ochoa Protein VAC14 homolog (Tax1-binding protein 2) Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371, ECO:0000269|PubMed:33098764}.
Q09019 DMWD S652 ochoa Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}.
Q12888 TP53BP1 S552 ochoa|psp TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}.
Q13177 PAK2 S152 ochoa Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}.
Q13568 IRF5 S301 psp Interferon regulatory factor 5 (IRF-5) Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000250|UniProtKB:P56477, ECO:0000269|PubMed:11303025, ECO:0000269|PubMed:15695821, ECO:0000269|PubMed:22412986, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:33440148}.
Q13796 SHROOM2 S1297 ochoa Protein Shroom2 (Apical-like protein) (Protein APXL) May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). {ECO:0000250}.
Q15262 PTPRK S828 ochoa Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}.
Q16236 NFE2L2 S577 psp Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2) Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). Also plays an important role in the regulation of the innate immune response and antiviral cytosolic DNA sensing. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF-alpha signaling (By similarity). Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6 (By similarity). Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the NRF2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (PubMed:30158636). Once activated, limits the release of pro-inflammatory cytokines in response to human coronavirus SARS-CoV-2 infection and to virus-derived ligands through a mechanism that involves inhibition of IRF3 dimerization. Also inhibits both SARS-CoV-2 replication, as well as the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism (PubMed:33009401). {ECO:0000250|UniProtKB:Q60795, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:19489739, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:29018201, ECO:0000269|PubMed:29590092, ECO:0000269|PubMed:30158636, ECO:0000269|PubMed:31398338, ECO:0000269|PubMed:33009401, ECO:0000269|PubMed:7937919}.
Q16649 NFIL3 S353 ochoa Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}.
Q2M3V2 SOWAHA S252 ochoa Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) None
Q2TB10 ZNF800 S419 ochoa Zinc finger protein 800 May be involved in transcriptional regulation.
Q5SVQ8 ZBTB41 S191 ochoa Zinc finger and BTB domain-containing protein 41 May be involved in transcriptional regulation.
Q5T0W9 FAM83B S915 ochoa Protein FAM83B Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}.
Q5T481 RBM20 S1120 ochoa RNA-binding protein 20 (RNA-binding motif protein 20) RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:26604136, PubMed:27496873, PubMed:27531932, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:34732726, PubMed:35427468). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:E9PT37, ECO:0000269|PubMed:22466703, ECO:0000269|PubMed:24960161, ECO:0000269|PubMed:26604136, ECO:0000269|PubMed:27496873, ECO:0000269|PubMed:27531932, ECO:0000269|PubMed:29895960, ECO:0000269|PubMed:30948719, ECO:0000269|PubMed:32840935, ECO:0000269|PubMed:34732726, ECO:0000269|PubMed:35427468}.
Q5VT25 CDC42BPA S674 ochoa Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9092543, PubMed:9418861). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.
Q68DQ2 CRYBG3 S716 ochoa Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}.
Q6KC79 NIPBL S103 ochoa Nipped-B-like protein (Delangin) (SCC2 homolog) Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.
Q6NXS1 PPP1R2B S130 ochoa Protein phosphatase inhibitor 2 family member B (PPP1R2 family member B) (Protein phosphatase 1, regulatory subunit 2 pseudogene 3) (Protein phosphatase inhibitor 2-like protein 3) Inhibitor of protein-phosphatase 1. {ECO:0000269|PubMed:23506001}.
Q6P0N0 MIS18BP1 S134 ochoa Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038, ECO:0000269|PubMed:17339379}.
Q6ZNJ1 NBEAL2 S1350 ochoa Neurobeachin-like protein 2 Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}.
Q711Q0 CEFIP S116 ochoa Cardiac-enriched FHL2-interacting protein Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}.
Q7Z2Z1 TICRR S1013 ochoa Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. {ECO:0000269|PubMed:20116089}.
Q7Z3J3 RGPD4 T1475 ochoa RanBP2-like and GRIP domain-containing protein 4 None
Q7Z4H7 HAUS6 S507 ochoa HAUS augmin-like complex subunit 6 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.
Q7Z6B7 SRGAP1 S196 ochoa SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269|PubMed:11672528}.
Q7Z7M9 GALNT5 S202 ochoa Polypeptide N-acetylgalactosaminyltransferase 5 (EC 2.4.1.41) (Polypeptide GalNAc transferase 5) (GalNAc-T5) (pp-GaNTase 5) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity). {ECO:0000250}.
Q86TU7 SETD3 S38 ochoa Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). {ECO:0000269|PubMed:30526847, ECO:0000269|PubMed:30626964, ECO:0000269|PubMed:30785395, ECO:0000269|PubMed:31388018, ECO:0000269|PubMed:31993215}.
Q86UX7 FERMT3 S31 ochoa Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2) Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}.
Q8IXS8 HYCC2 S508 ochoa Hyccin 2 Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. {ECO:0000305|PubMed:26571211}.
Q8IXT5 RBM12B S638 ochoa RNA-binding protein 12B (RNA-binding motif protein 12B) None
Q8IXT5 RBM12B S710 ochoa RNA-binding protein 12B (RNA-binding motif protein 12B) None
Q8IXT5 RBM12B S718 ochoa RNA-binding protein 12B (RNA-binding motif protein 12B) None
Q8IZD2 KMT2E S531 ochoa Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5) Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:23798402, PubMed:24130829). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:23798402, PubMed:24130829). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}.
Q8NB16 MLKL S125 ochoa Mixed lineage kinase domain-like protein (hMLKL) Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). {ECO:0000250|UniProtKB:Q9D2Y4, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:29883610}.
Q8TE68 EPS8L1 Y684 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1) Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. {ECO:0000269|PubMed:14565974}.
Q8TF72 SHROOM3 S443 ochoa Protein Shroom3 (Shroom-related protein) (hShrmL) Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}.
Q92576 PHF3 S125 ochoa PHD finger protein 3 None
Q93009 USP7 S963 ochoa Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) Hydrolase that deubiquitinates target proteins such as ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX (PubMed:11923872, PubMed:15053880, PubMed:16964248, PubMed:18716620, PubMed:25283148, PubMed:25865756, PubMed:26678539, PubMed:28655758, PubMed:33544460, PubMed:35216969). Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation (PubMed:15053880, PubMed:16845383, PubMed:18566590, PubMed:20153724). Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis (PubMed:25283148). Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis (PubMed:11923872, PubMed:26786098). Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity (PubMed:16964248). In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML (PubMed:18716620). Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation (PubMed:26678539). Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (PubMed:22466611, PubMed:22466612). Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1 (PubMed:21745816, PubMed:22411829). Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937). Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo (PubMed:20601937). Exhibits a preference towards 'Lys-48'-linked ubiquitin chains (PubMed:22689415). Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222). Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins (PubMed:27123980). Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells (PubMed:21258371). Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling (PubMed:26365382). It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1 (PubMed:26365382). Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling (PubMed:35216969). {ECO:0000269|PubMed:11923872, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:16845383, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:20153724, ECO:0000269|PubMed:20601937, ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:21745816, ECO:0000269|PubMed:22411829, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612, ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:25865756, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:26365382, ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:26786098, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:28655758, ECO:0000269|PubMed:33544460, ECO:0000269|PubMed:35216969}.; FUNCTION: (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. {ECO:0000269|PubMed:14506283, ECO:0000269|PubMed:16160161, ECO:0000269|PubMed:18590780}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML. {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761}.
Q96GX5 MASTL S619 ochoa Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
Q96K31 C8orf76 S25 ochoa Uncharacterized protein C8orf76 None
Q96K83 ZNF521 S273 ochoa Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}.
Q96KP1 EXOC2 S404 ochoa Exocyst complex component 2 (Exocyst complex component Sec5) Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000269|PubMed:12459492, ECO:0000269|PubMed:32639540}.
Q96R06 SPAG5 S835 ochoa Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}.
Q99666 RGPD5 T1474 ochoa RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) None
Q99708 RBBP8 S276 psp DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:23273981, PubMed:26721387, PubMed:27814491, PubMed:27889449, PubMed:30787182). HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191, PubMed:23273981, PubMed:27814491, PubMed:27889449, PubMed:30787182). Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191). Specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts: recruited to DSBs by NBN following phosphorylation by CDK1, and promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (PubMed:27814491, PubMed:27889449, PubMed:30787182, PubMed:33836577). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462). Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity). Binds preferentially to DNA Y-junctions and to DNA substrates with blocked ends and promotes intermolecular DNA bridging (PubMed:30601117). {ECO:0000250|UniProtKB:Q80YR6, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:23273981, ECO:0000269|PubMed:26721387, ECO:0000269|PubMed:27814491, ECO:0000269|PubMed:27889449, ECO:0000269|PubMed:30601117, ECO:0000269|PubMed:30787182, ECO:0000269|PubMed:33836577}.
Q9BUG6 ZSCAN5A S245 ochoa Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) May be involved in transcriptional regulation.
Q9BVA0 KATNB1 S360 ochoa Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:10751153}.
Q9BW04 SARG S580 ochoa Specifically androgen-regulated gene protein Putative androgen-specific receptor. {ECO:0000269|PubMed:15525603}.
Q9BY89 KIAA1671 S1224 ochoa Uncharacterized protein KIAA1671 None
Q9BZK3 NACA4P S113 ochoa Putative nascent polypeptide-associated complex subunit alpha-like protein (Alpha-NAC pseudogene 1) (NAC-alpha pseudogene 1) (NACA family member 4, pseudogene) None
Q9C0D2 CEP295 S1388 ochoa Centrosomal protein of 295 kDa Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865, PubMed:38154379). Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865). May be involved in ciliogenesis (PubMed:38154379). {ECO:0000269|PubMed:20844083, ECO:0000269|PubMed:25131205, ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:32060285, ECO:0000269|PubMed:38154379}.
Q9C0D7 ZC3H12C S123 ochoa Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) May function as RNase and regulate the levels of target RNA species. {ECO:0000305}.
Q9H165 BCL11A S114 ochoa BCL11 transcription factor A (B-cell CLL/lymphoma 11A) (B-cell lymphoma/leukemia 11A) (BCL-11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353, PubMed:39423807). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:26375765, PubMed:29606353, PubMed:39423807, PubMed:39607926). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000269|PubMed:39423807, ECO:0000269|PubMed:39607926, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.
Q9H257 CARD9 S277 ochoa Caspase recruitment domain-containing protein 9 (hCARD9) Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors (PubMed:26961233, PubMed:33558980). CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota (PubMed:24231284, PubMed:25057046, PubMed:25702837, PubMed:26521038, PubMed:26679537, PubMed:26961233, PubMed:27777981, PubMed:29080677, PubMed:33558980). Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11053425, PubMed:26488816, PubMed:26961233, PubMed:31296852, PubMed:33558980). CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells (PubMed:24231284). Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota (PubMed:33548172). Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection (PubMed:33548172). Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:A2AIV8, ECO:0000269|PubMed:11053425, ECO:0000269|PubMed:24231284, ECO:0000269|PubMed:25057046, ECO:0000269|PubMed:25702837, ECO:0000269|PubMed:26488816, ECO:0000269|PubMed:26521038, ECO:0000269|PubMed:26679537, ECO:0000269|PubMed:26961233, ECO:0000269|PubMed:27777981, ECO:0000269|PubMed:29080677, ECO:0000269|PubMed:31296852, ECO:0000269|PubMed:33548172, ECO:0000269|PubMed:33558980}.
Q9H2Y7 ZNF106 S893 ochoa Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}.
Q9H582 ZNF644 S1189 ochoa Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) May be involved in transcriptional regulation.
Q9H694 BICC1 S633 ochoa Protein bicaudal C homolog 1 (Bic-C) Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}.
Q9H6S3 EPS8L2 Y678 ochoa Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.
Q9HCK8 CHD8 S2046 ochoa Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}.
Q9NQC3 RTN4 S739 ochoa Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). {ECO:0000269|PubMed:24262037, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26906412, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:27786289, ECO:0000305}.; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:19699797}.; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:11126360, ECO:0000269|PubMed:16965550, ECO:0000305}.; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550). {ECO:0000250|UniProtKB:Q99P72, ECO:0000269|PubMed:16965550}.
Q9NRR4 DROSHA S355 ochoa|psp Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity). {ECO:0000250|UniProtKB:Q5HZJ0, ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.
Q9NS25 SPANXB1 S69 ochoa Sperm protein associated with the nucleus on the X chromosome B1 (Cancer/testis antigen 11.2) (CT11.2) (Nuclear-associated protein SPAN-Xb) (SPANX-B) (SPANX family member B1) (SPANX family member F1) None
Q9NS26 SPANXA1 S63 ochoa Sperm protein associated with the nucleus on the X chromosome A (Cancer/testis antigen 11.1) (CT11.1) (Nuclear-associated protein SPAN-Xa) (SPAN-X) (SPANX-A) (SPANX family member A) None
Q9NXH9 TRMT1 S517 ochoa tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA methyltransferase 1) (hTRM1) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase) Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:10982862, PubMed:28784718, PubMed:37204604, PubMed:39786990). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (PubMed:28784718). {ECO:0000269|PubMed:10982862, ECO:0000269|PubMed:28784718, ECO:0000269|PubMed:37204604, ECO:0000269|PubMed:39786990}.
Q9NYW8 RBAK S78 ochoa RB-associated KRAB zinc finger protein (RB-associated KRAB repressor) (hRBaK) (Zinc finger protein 769) May repress E2F-dependent transcription. May promote AR-dependent transcription. {ECO:0000269|PubMed:10702291, ECO:0000269|PubMed:14664718}.
Q9NZ56 FMN2 S361 ochoa Formin-2 Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:21730168, PubMed:22330775). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:21730168, PubMed:22330775). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed:23375502). {ECO:0000250|UniProtKB:Q9JL04, ECO:0000269|PubMed:21730168, ECO:0000269|PubMed:22330775, ECO:0000269|PubMed:23375502, ECO:0000269|PubMed:26287480}.
Q9P0N8 MARCHF2 S223 ochoa E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2) E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:14722266, PubMed:16428329). Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Ubiquitinates and therefore mediates the degradation of DLG1 (PubMed:17980554). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (PubMed:31142615). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (PubMed:32935379). May be involved in endosomal trafficking through interaction with STX6 (PubMed:15689499). {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:15689499, ECO:0000269|PubMed:16428329, ECO:0000269|PubMed:17980554, ECO:0000269|PubMed:23818989, ECO:0000269|PubMed:31142615, ECO:0000269|PubMed:32935379}.; FUNCTION: (Microbial infection) Positively regulates the degradation of Vesicular stomatitis virus (VSV) G protein via the lysosomal degradation pathway (PubMed:29573664). Represses HIV-1 viral production and may inhibit the translocation of HIV-1 env to the cell surface, resulting in decreased viral cell-cell transmission (PubMed:29573664). {ECO:0000269|PubMed:29573664}.
Q9UHN1 POLG2 S38 ochoa DNA polymerase subunit gamma-2 (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta) Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. {ECO:0000269|PubMed:11477093, ECO:0000269|PubMed:11477094, ECO:0000269|PubMed:11504725, ECO:0000269|PubMed:15167897, ECO:0000269|PubMed:19837034, ECO:0000269|PubMed:26056153, ECO:0000269|PubMed:30157269, ECO:0000269|PubMed:31778857, ECO:0000269|PubMed:37202477}.
Q9UNZ2 NSFL1C S177 ochoa NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000250|UniProtKB:O35987, ECO:0000269|PubMed:15498563, ECO:0000269|PubMed:23649807}.
Q9UPV0 CEP164 S472 ochoa Centrosomal protein of 164 kDa (Cep164) Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.
Q9UPV9 TRAK1 S393 ochoa Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). {ECO:0000250|UniProtKB:Q960V3, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:24995978}.
Q9Y250 LZTS1 S254 ochoa Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.
Q9Y520 PRRC2C S2143 ochoa Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Required for efficient formation of stress granules. {ECO:0000269|PubMed:29395067}.
V9GYD0 ARL2-SNX15 S45 ochoa ARL2-SNX15 readthrough (NMD candidate) None
P13798 APEH S97 Sugiyama Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus (PubMed:10719179, PubMed:1740429, PubMed:2006156). It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins (PubMed:10719179). {ECO:0000250|UniProtKB:P13676, ECO:0000269|PubMed:10719179, ECO:0000269|PubMed:1740429, ECO:0000269|PubMed:2006156}.
Q12824 SMARCB1 S111 Sugiyama SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5) Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. {ECO:0000250|UniProtKB:Q9Z0H3, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:12226744, ECO:0000269|PubMed:14604992, ECO:0000269|PubMed:16267391, ECO:0000269|PubMed:16314535, ECO:0000269|PubMed:9448295}.
P09132 SRP19 S69 Sugiyama Signal recognition particle 19 kDa protein (SRP19) Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity). {ECO:0000250|UniProtKB:J9PAS6}.
Q8NE63 HIPK4 S337 Sugiyama Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). {ECO:0000250, ECO:0000305}.
Download
reactome_id name p -log10_p
R-HSA-9933946 Formation of the embryonic stem cell BAF (esBAF) complex 0.000386 3.413
R-HSA-9934037 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 0.000853 3.069
R-HSA-9932451 SWI/SNF chromatin remodelers 0.001575 2.803
R-HSA-9932444 ATP-dependent chromatin remodelers 0.001575 2.803
R-HSA-9818749 Regulation of NFE2L2 gene expression 0.002031 2.692
R-HSA-1640170 Cell Cycle 0.002542 2.595
R-HSA-9006821 Alternative Lengthening of Telomeres (ALT) 0.014427 1.841
R-HSA-9673013 Diseases of Telomere Maintenance 0.014427 1.841
R-HSA-9670621 Defective Inhibition of DNA Recombination at Telomere 0.014427 1.841
R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.014427 1.841
R-HSA-9670613 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 0.014427 1.841
R-HSA-9709275 Impaired BRCA2 translocation to the nucleus 0.014427 1.841
R-HSA-9763198 Impaired BRCA2 binding to SEM1 (DSS1) 0.014427 1.841
R-HSA-9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 0.014427 1.841
R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.006978 2.156
R-HSA-9709603 Impaired BRCA2 binding to PALB2 0.013456 1.871
R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function 0.014533 1.838
R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.014533 1.838
R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... 0.014533 1.838
R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 0.014533 1.838
R-HSA-9933939 Formation of the polybromo-BAF (pBAF) complex 0.007786 2.109
R-HSA-9933937 Formation of the canonical BAF (cBAF) complex 0.007786 2.109
R-HSA-5696398 Nucleotide Excision Repair 0.010794 1.967
R-HSA-9823739 Formation of the anterior neural plate 0.008634 2.064
R-HSA-73894 DNA Repair 0.006759 2.170
R-HSA-177929 Signaling by EGFR 0.011666 1.933
R-HSA-1852241 Organelle biogenesis and maintenance 0.012391 1.907
R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.028648 1.543
R-HSA-9818035 NFE2L2 regulating ER-stress associated genes 0.042666 1.370
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 ... 0.042666 1.370
R-HSA-9818025 NFE2L2 regulating TCA cycle genes 0.049599 1.305
R-HSA-9818026 NFE2L2 regulating inflammation associated genes 0.049599 1.305
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 0.056482 1.248
R-HSA-9818032 NFE2L2 regulating MDR associated enzymes 0.083526 1.078
R-HSA-9700645 ALK mutants bind TKIs 0.083526 1.078
R-HSA-9818028 NFE2L2 regulates pentose phosphate pathway genes 0.103302 0.986
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... 0.021726 1.663
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 0.116251 0.935
R-HSA-9709570 Impaired BRCA2 binding to RAD51 0.027181 1.566
R-HSA-5696394 DNA Damage Recognition in GG-NER 0.034684 1.460
R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 0.036271 1.440
R-HSA-9670095 Inhibition of DNA recombination at telomere 0.046355 1.334
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.160129 0.796
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.059241 1.227
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.063126 1.200
R-HSA-6803529 FGFR2 alternative splicing 0.184226 0.735
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.190142 0.721
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.190142 0.721
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.079472 1.100
R-HSA-6782135 Dual incision in TC-NER 0.083745 1.077
R-HSA-445095 Interaction between L1 and Ankyrins 0.213384 0.671
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.213384 0.671
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.213384 0.671
R-HSA-9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 0.088087 1.055
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.219090 0.659
R-HSA-167287 HIV elongation arrest and recovery 0.219090 0.659
R-HSA-113418 Formation of the Early Elongation Complex 0.219090 0.659
R-HSA-167290 Pausing and recovery of HIV elongation 0.219090 0.659
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centr... 0.094723 1.024
R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.094723 1.024
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... 0.230380 0.638
R-HSA-8854518 AURKA Activation by TPX2 0.101497 0.994
R-HSA-1855196 IP3 and IP4 transport between cytosol and nucleus 0.235965 0.627
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.235965 0.627
R-HSA-1855229 IP6 and IP7 transport between cytosol and nucleus 0.235965 0.627
R-HSA-1855170 IPs transport between nucleus and cytosol 0.247013 0.607
R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.247013 0.607
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.252477 0.598
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.117797 0.929
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.122568 0.912
R-HSA-380287 Centrosome maturation 0.122568 0.912
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.263289 0.580
R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 0.273945 0.562
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.284449 0.546
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.289644 0.538
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.289644 0.538
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.157154 0.804
R-HSA-9759194 Nuclear events mediated by NFE2L2 0.257173 0.590
R-HSA-5693607 Processing of DNA double-strand break ends 0.137155 0.863
R-HSA-167169 HIV Transcription Elongation 0.289644 0.538
R-HSA-9818027 NFE2L2 regulating anti-oxidant/detoxification enzymes 0.252477 0.598
R-HSA-9818030 NFE2L2 regulating tumorigenic genes 0.116251 0.935
R-HSA-72086 mRNA Capping 0.224756 0.648
R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.162238 0.790
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.289644 0.538
R-HSA-169911 Regulation of Apoptosis 0.263289 0.580
R-HSA-5693538 Homology Directed Repair 0.072172 1.142
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.284449 0.546
R-HSA-9675136 Diseases of DNA Double-Strand Break Repair 0.036271 1.440
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.039527 1.403
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 0.064714 1.189
R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.083526 1.078
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.178267 0.749
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.184226 0.735
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.037886 1.422
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.042889 1.368
R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 0.284449 0.546
R-HSA-76046 RNA Polymerase III Transcription Initiation 0.230380 0.638
R-HSA-9860276 SLC15A4:TASL-dependent IRF5 activation 0.056482 1.248
R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.103785 0.984
R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.247013 0.607
R-HSA-74158 RNA Polymerase III Transcription 0.039527 1.403
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogen... 0.206469 0.685
R-HSA-5619507 Activation of HOX genes during differentiation 0.206469 0.685
R-HSA-5693537 Resolution of D-Loop Structures 0.034684 1.460
R-HSA-9675126 Diseases of mitotic cell cycle 0.031596 1.500
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.184226 0.735
R-HSA-912446 Meiotic recombination 0.069109 1.160
R-HSA-5696395 Formation of Incision Complex in GG-NER 0.289644 0.538
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.289644 0.538
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.033126 1.480
R-HSA-9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 0.294801 0.530
R-HSA-5693532 DNA Double-Strand Break Repair 0.036702 1.435
R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.144587 0.840
R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication 0.160129 0.796
R-HSA-2470946 Cohesin Loading onto Chromatin 0.070101 1.154
R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.076838 1.114
R-HSA-428543 Inactivation of CDC42 and RAC1 0.083526 1.078
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects 0.116251 0.935
R-HSA-9933947 Formation of the non-canonical BAF (ncBAF) complex 0.116251 0.935
R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.129015 0.889
R-HSA-73980 RNA Polymerase III Transcription Termination 0.153996 0.812
R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.160129 0.796
R-HSA-350054 Notch-HLH transcription pathway 0.184226 0.735
R-HSA-168325 Viral Messenger RNA Synthesis 0.090283 1.044
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.252477 0.598
R-HSA-180910 Vpr-mediated nuclear import of PICs 0.273945 0.562
R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 0.230380 0.638
R-HSA-9707616 Heme signaling 0.092495 1.034
R-HSA-447043 Neurofascin interactions 0.063316 1.198
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.147818 0.830
R-HSA-3295583 TRP channels 0.207636 0.683
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 0.166219 0.779
R-HSA-5578749 Transcriptional regulation by small RNAs 0.115429 0.938
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.252477 0.598
R-HSA-5213460 RIPK1-mediated regulated necrosis 0.279216 0.554
R-HSA-193697 p75NTR regulates axonogenesis 0.083526 1.078
R-HSA-1500620 Meiosis 0.147083 0.832
R-HSA-9832991 Formation of the posterior neural plate 0.096758 1.014
R-HSA-1483226 Synthesis of PI 0.096758 1.014
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis 0.103302 0.986
R-HSA-77387 Insulin receptor recycling 0.219090 0.659
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects 0.230380 0.638
R-HSA-5675482 Regulation of necroptotic cell death 0.247013 0.607
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.144587 0.840
R-HSA-162906 HIV Infection 0.267510 0.573
R-HSA-68877 Mitotic Prometaphase 0.200562 0.698
R-HSA-182971 EGFR downregulation 0.030095 1.522
R-HSA-6794361 Neurexins and neuroligins 0.071143 1.148
R-HSA-180746 Nuclear import of Rev protein 0.257903 0.589
R-HSA-3928664 Ephrin signaling 0.153996 0.812
R-HSA-5218920 VEGFR2 mediated vascular permeability 0.294801 0.530
R-HSA-9707587 Regulation of HMOX1 expression and activity 0.042666 1.370
R-HSA-447038 NrCAM interactions 0.049599 1.305
R-HSA-8948747 Regulation of PTEN localization 0.070101 1.154
R-HSA-68884 Mitotic Telophase/Cytokinesis 0.103302 0.986
R-HSA-428540 Activation of RAC1 0.103302 0.986
R-HSA-203927 MicroRNA (miRNA) biogenesis 0.021726 1.663
R-HSA-429947 Deadenylation of mRNA 0.196015 0.708
R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma ... 0.213384 0.671
R-HSA-69473 G2/M DNA damage checkpoint 0.120177 0.920
R-HSA-177243 Interactions of Rev with host cellular proteins 0.289644 0.538
R-HSA-176033 Interactions of Vpr with host cellular proteins 0.289644 0.538
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.294801 0.530
R-HSA-5617833 Cilium Assembly 0.066750 1.176
R-HSA-9686347 Microbial modulation of RIPK1-mediated regulated necrosis 0.070101 1.154
R-HSA-4839726 Chromatin organization 0.047157 1.326
R-HSA-73886 Chromosome Maintenance 0.076041 1.119
R-HSA-9675135 Diseases of DNA repair 0.059241 1.227
R-HSA-164944 Nef and signal transduction 0.063316 1.198
R-HSA-447041 CHL1 interactions 0.070101 1.154
R-HSA-9693928 Defective RIPK1-mediated regulated necrosis 0.090166 1.045
R-HSA-9005895 Pervasive developmental disorders 0.109800 0.959
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 0.109800 0.959
R-HSA-9697154 Disorders of Nervous System Development 0.109800 0.959
R-HSA-3270619 IRF3-mediated induction of type I IFN 0.129015 0.889
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... 0.033126 1.480
R-HSA-5620916 VxPx cargo-targeting to cilium 0.166219 0.779
R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.279216 0.554
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.207636 0.683
R-HSA-917977 Transferrin endocytosis and recycling 0.263289 0.580
R-HSA-6794362 Protein-protein interactions at synapses 0.147083 0.832
R-HSA-1251985 Nuclear signaling by ERBB4 0.289644 0.538
R-HSA-9824585 Regulation of MITF-M-dependent genes involved in pigmentation 0.057331 1.242
R-HSA-5689877 Josephin domain DUBs 0.090166 1.045
R-HSA-389359 CD28 dependent Vav1 pathway 0.116251 0.935
R-HSA-9675151 Disorders of Developmental Biology 0.141595 0.849
R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.284449 0.546
R-HSA-68886 M Phase 0.170553 0.768
R-HSA-69275 G2/M Transition 0.063124 1.200
R-HSA-453274 Mitotic G2-G2/M phases 0.064924 1.188
R-HSA-9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... 0.017975 1.745
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.201847 0.695
R-HSA-1538133 G0 and Early G1 0.241509 0.617
R-HSA-68875 Mitotic Prophase 0.254490 0.594
R-HSA-8863795 Downregulation of ERBB2 signaling 0.230380 0.638
R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.113074 0.947
R-HSA-3214858 RMTs methylate histone arginines 0.055444 1.256
R-HSA-1474165 Reproduction 0.286693 0.543
R-HSA-69278 Cell Cycle, Mitotic 0.064869 1.188
R-HSA-69620 Cell Cycle Checkpoints 0.144913 0.839
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.129015 0.889
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.213384 0.671
R-HSA-211000 Gene Silencing by RNA 0.056494 1.248
R-HSA-8852135 Protein ubiquitination 0.122568 0.912
R-HSA-69481 G2/M Checkpoints 0.275963 0.559
R-HSA-157579 Telomere Maintenance 0.185457 0.732
R-HSA-9842860 Regulation of endogenous retroelements 0.198556 0.702
R-HSA-6787450 tRNA modification in the mitochondrion 0.141595 0.849
R-HSA-389977 Post-chaperonin tubulin folding pathway 0.166219 0.779
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.241509 0.617
R-HSA-162909 Host Interactions of HIV factors 0.265225 0.576
R-HSA-6804757 Regulation of TP53 Degradation 0.268636 0.571
R-HSA-9648002 RAS processing 0.284449 0.546
R-HSA-5621575 CD209 (DC-SIGN) signaling 0.196015 0.708
R-HSA-9707564 Cytoprotection by HMOX1 0.142100 0.847
R-HSA-3214841 PKMTs methylate histone lysines 0.294801 0.530
R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.284449 0.546
R-HSA-6807004 Negative regulation of MET activity 0.166219 0.779
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 0.219090 0.659
R-HSA-3247509 Chromatin modifying enzymes 0.114600 0.941
R-HSA-909733 Interferon alpha/beta signaling 0.241088 0.618
R-HSA-8876384 Listeria monocytogenes entry into host cells 0.178267 0.749
R-HSA-9008059 Interleukin-37 signaling 0.028623 1.543
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in ... 0.184226 0.735
R-HSA-9022692 Regulation of MECP2 expression and activity 0.247013 0.607
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.273945 0.562
R-HSA-391251 Protein folding 0.169919 0.770
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.201847 0.695
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.027563 1.560
R-HSA-8941326 RUNX2 regulates bone development 0.268636 0.571
R-HSA-8953750 Transcriptional Regulation by E2F6 0.044609 1.351
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.135328 0.869
R-HSA-264876 Insulin processing 0.213384 0.671
R-HSA-202433 Generation of second messenger molecules 0.289644 0.538
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 0.033126 1.480
R-HSA-168638 NOD1/2 Signaling Pathway 0.257903 0.589
R-HSA-1839126 FGFR2 mutant receptor activation 0.268636 0.571
R-HSA-1592230 Mitochondrial biogenesis 0.070903 1.149
R-HSA-9856651 MITF-M-dependent gene expression 0.034753 1.459
R-HSA-1834941 STING mediated induction of host immune responses 0.160129 0.796
R-HSA-72306 tRNA processing 0.159179 0.798
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.190142 0.721
R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.081600 1.088
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.091408 1.039
R-HSA-9700206 Signaling by ALK in cancer 0.214416 0.669
R-HSA-9730414 MITF-M-regulated melanocyte development 0.090709 1.042
R-HSA-3700989 Transcriptional Regulation by TP53 0.279059 0.554
R-HSA-9725370 Signaling by ALK fusions and activated point mutants 0.214416 0.669
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... 0.099224 1.003
R-HSA-9020591 Interleukin-12 signaling 0.124972 0.903
R-HSA-447115 Interleukin-12 family signaling 0.154624 0.811
R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.299922 0.523
R-HSA-167161 HIV Transcription Initiation 0.299922 0.523
R-HSA-75953 RNA Polymerase II Transcription Initiation 0.299922 0.523
R-HSA-73776 RNA Polymerase II Promoter Escape 0.310053 0.509
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.315063 0.502
R-HSA-69231 Cyclin D associated events in G1 0.315063 0.502
R-HSA-69236 G1 Phase 0.315063 0.502
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.320038 0.495
R-HSA-774815 Nucleosome assembly 0.320038 0.495
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.320038 0.495
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.320038 0.495
R-HSA-5688426 Deubiquitination 0.322791 0.491
R-HSA-162599 Late Phase of HIV Life Cycle 0.324078 0.489
R-HSA-72165 mRNA Splicing - Minor Pathway 0.324977 0.488
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.324977 0.488
R-HSA-75153 Apoptotic execution phase 0.324977 0.488
R-HSA-389356 Co-stimulation by CD28 0.334748 0.475
R-HSA-9766229 Degradation of CDH1 0.339581 0.469
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.339581 0.469
R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.339581 0.469
R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.339581 0.469
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.339581 0.469
R-HSA-9758941 Gastrulation 0.342601 0.465
R-HSA-5655253 Signaling by FGFR2 in disease 0.344379 0.463
R-HSA-9755511 KEAP1-NFE2L2 pathway 0.347866 0.459
R-HSA-9711123 Cellular response to chemical stress 0.348571 0.458
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.350177 0.456
R-HSA-446652 Interleukin-1 family signaling 0.350493 0.455
R-HSA-69306 DNA Replication 0.353117 0.452
R-HSA-112382 Formation of RNA Pol II elongation complex 0.353872 0.451
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.353872 0.451
R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.358354 0.446
R-HSA-75955 RNA Polymerase II Transcription Elongation 0.358567 0.445
R-HSA-9639288 Amino acids regulate mTORC1 0.358567 0.445
R-HSA-445355 Smooth Muscle Contraction 0.358567 0.445
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.363229 0.440
R-HSA-162587 HIV Life Cycle 0.363575 0.439
R-HSA-3214815 HDACs deacetylate histones 0.367856 0.434
R-HSA-877300 Interferon gamma signaling 0.368781 0.433
R-HSA-5633007 Regulation of TP53 Activity 0.371378 0.430
R-HSA-9662361 Sensory processing of sound by outer hair cells of the cochlea 0.372451 0.429
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.372451 0.429
R-HSA-2980766 Nuclear Envelope Breakdown 0.377012 0.424
R-HSA-9764561 Regulation of CDH1 Function 0.377012 0.424
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... 0.381540 0.418
R-HSA-194441 Metabolism of non-coding RNA 0.386036 0.413
R-HSA-191859 snRNP Assembly 0.386036 0.413
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... 0.386036 0.413
R-HSA-429914 Deadenylation-dependent mRNA decay 0.386036 0.413
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.390500 0.408
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.390500 0.408
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.390500 0.408
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.390500 0.408
R-HSA-1227986 Signaling by ERBB2 0.390500 0.408
R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.390500 0.408
R-HSA-6784531 tRNA processing in the nucleus 0.399330 0.399
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.399330 0.399
R-HSA-5621481 C-type lectin receptors (CLRs) 0.402195 0.396
R-HSA-373755 Semaphorin interactions 0.403698 0.394
R-HSA-69615 G1/S DNA Damage Checkpoints 0.403698 0.394
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... 0.408034 0.389
R-HSA-6802952 Signaling by BRAF and RAF1 fusions 0.412338 0.385
R-HSA-9909649 Regulation of PD-L1(CD274) transcription 0.416612 0.380
R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.416612 0.380
R-HSA-5693606 DNA Double Strand Break Response 0.420855 0.376
R-HSA-168255 Influenza Infection 0.422349 0.374
R-HSA-167172 Transcription of the HIV genome 0.425067 0.372
R-HSA-5218859 Regulated Necrosis 0.425067 0.372
R-HSA-9662360 Sensory processing of sound by inner hair cells of the cochlea 0.425067 0.372
R-HSA-913709 O-linked glycosylation of mucins 0.425067 0.372
R-HSA-69202 Cyclin E associated events during G1/S transition 0.433401 0.363
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.433401 0.363
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.441615 0.355
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.445678 0.351
R-HSA-69052 Switching of origins to a post-replicative state 0.445678 0.351
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.445678 0.351
R-HSA-983712 Ion channel transport 0.447048 0.350
R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.449711 0.347
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 0.449711 0.347
R-HSA-1236394 Signaling by ERBB4 0.449711 0.347
R-HSA-1222556 ROS and RNS production in phagocytes 0.449711 0.347
R-HSA-1226099 Signaling by FGFR in disease 0.449711 0.347
R-HSA-1169408 ISG15 antiviral mechanism 0.453715 0.343
R-HSA-917937 Iron uptake and transport 0.453715 0.343
R-HSA-212165 Epigenetic regulation of gene expression 0.455530 0.341
R-HSA-5689603 UCH proteinases 0.457691 0.339
R-HSA-1980143 Signaling by NOTCH1 0.457691 0.339
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling 0.461637 0.336
R-HSA-9609690 HCMV Early Events 0.463987 0.333
R-HSA-383280 Nuclear Receptor transcription pathway 0.465555 0.332
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.465555 0.332
R-HSA-9659379 Sensory processing of sound 0.469445 0.328
R-HSA-5654738 Signaling by FGFR2 0.473307 0.325
R-HSA-6806834 Signaling by MET 0.473307 0.325
R-HSA-376176 Signaling by ROBO receptors 0.480623 0.318
R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.480947 0.318
R-HSA-74160 Gene expression (Transcription) 0.481212 0.318
R-HSA-5357801 Programmed Cell Death 0.487657 0.312
R-HSA-6802957 Oncogenic MAPK signaling 0.492202 0.308
R-HSA-5687128 MAPK6/MAPK4 signaling 0.492202 0.308
R-HSA-141424 Amplification of signal from the kinetochores 0.495899 0.305
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... 0.495899 0.305
R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.499570 0.301
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.499570 0.301
R-HSA-390466 Chaperonin-mediated protein folding 0.503215 0.298
R-HSA-9645723 Diseases of programmed cell death 0.506833 0.295
R-HSA-8986944 Transcriptional Regulation by MECP2 0.517531 0.286
R-HSA-74752 Signaling by Insulin receptor 0.524535 0.280
R-HSA-2682334 EPH-Ephrin signaling 0.524535 0.280
R-HSA-8878171 Transcriptional regulation by RUNX1 0.535208 0.271
R-HSA-72764 Eukaryotic Translation Termination 0.538241 0.269
R-HSA-5389840 Mitochondrial translation elongation 0.541606 0.266
R-HSA-6807878 COPI-mediated anterograde transport 0.541606 0.266
R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.541606 0.266
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.541606 0.266
R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.544947 0.264
R-HSA-5368286 Mitochondrial translation initiation 0.548264 0.261
R-HSA-190236 Signaling by FGFR 0.548264 0.261
R-HSA-3214847 HATs acetylate histones 0.551556 0.258
R-HSA-193704 p75 NTR receptor-mediated signalling 0.551556 0.258
R-HSA-69618 Mitotic Spindle Checkpoint 0.554825 0.256
R-HSA-70171 Glycolysis 0.554825 0.256
R-HSA-1483255 PI Metabolism 0.561292 0.251
R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.561292 0.251
R-HSA-9937383 Mitochondrial ribosome-associated quality control 0.564491 0.248
R-HSA-913531 Interferon Signaling 0.564892 0.248
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.567666 0.246
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.580139 0.236
R-HSA-69239 Synthesis of DNA 0.580139 0.236
R-HSA-2672351 Stimuli-sensing channels 0.583201 0.234
R-HSA-9609646 HCMV Infection 0.585784 0.232
R-HSA-5419276 Mitochondrial translation termination 0.586241 0.232
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 0.586241 0.232
R-HSA-202403 TCR signaling 0.589259 0.230
R-HSA-2871796 FCERI mediated MAPK activation 0.595230 0.225
R-HSA-1483249 Inositol phosphate metabolism 0.595230 0.225
R-HSA-388841 Regulation of T cell activation by CD28 family 0.597784 0.223
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.598183 0.223
R-HSA-212436 Generic Transcription Pathway 0.598665 0.223
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.606915 0.217
R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.609783 0.215
R-HSA-373760 L1CAM interactions 0.612631 0.213
R-HSA-70326 Glucose metabolism 0.615458 0.211
R-HSA-2980736 Peptide hormone metabolism 0.615458 0.211
R-HSA-8878166 Transcriptional regulation by RUNX2 0.621051 0.207
R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.626564 0.203
R-HSA-3371556 Cellular response to heat stress 0.626564 0.203
R-HSA-9816359 Maternal to zygotic transition (MZT) 0.631997 0.199
R-HSA-72766 Translation 0.638085 0.195
R-HSA-69206 G1/S Transition 0.639999 0.194
R-HSA-9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... 0.639999 0.194
R-HSA-9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 0.639999 0.194
R-HSA-194138 Signaling by VEGF 0.639999 0.194
R-HSA-9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 0.639999 0.194
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.641382 0.193
R-HSA-114608 Platelet degranulation 0.645238 0.190
R-HSA-9843745 Adipogenesis 0.658008 0.182
R-HSA-9909396 Circadian clock 0.660506 0.180
R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.662987 0.178
R-HSA-1483257 Phospholipid metabolism 0.669485 0.174
R-HSA-9018519 Estrogen-dependent gene expression 0.672730 0.172
R-HSA-5173105 O-linked glycosylation 0.675122 0.171
R-HSA-5368287 Mitochondrial translation 0.677497 0.169
R-HSA-6798695 Neutrophil degranulation 0.678285 0.169
R-HSA-6807070 PTEN Regulation 0.679854 0.168
R-HSA-9705671 SARS-CoV-2 activates/modulates innate and adaptive immune responses 0.689114 0.162
R-HSA-1280215 Cytokine Signaling in Immune system 0.689749 0.161
R-HSA-8856828 Clathrin-mediated endocytosis 0.691388 0.160
R-HSA-449147 Signaling by Interleukins 0.694788 0.158
R-HSA-453279 Mitotic G1 phase and G1/S transition 0.698109 0.156
R-HSA-199977 ER to Golgi Anterograde Transport 0.700317 0.155
R-HSA-69242 S Phase 0.702509 0.153
R-HSA-9679191 Potential therapeutics for SARS 0.706845 0.151
R-HSA-73857 RNA Polymerase II Transcription 0.712593 0.147
R-HSA-9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 0.715331 0.145
R-HSA-73887 Death Receptor Signaling 0.715331 0.145
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.715331 0.145
R-HSA-1989781 PPARA activates gene expression 0.717414 0.144
R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.721535 0.142
R-HSA-9610379 HCMV Late Events 0.721535 0.142
R-HSA-9711097 Cellular response to starvation 0.723573 0.141
R-HSA-9006936 Signaling by TGFB family members 0.727605 0.138
R-HSA-109581 Apoptosis 0.731578 0.136
R-HSA-2467813 Separation of Sister Chromatids 0.735494 0.133
R-HSA-5619102 SLC transporter disorders 0.741262 0.130
R-HSA-5683057 MAPK family signaling cascades 0.748752 0.126
R-HSA-8953854 Metabolism of RNA 0.750756 0.125
R-HSA-9909648 Regulation of PD-L1(CD274) expression 0.752427 0.124
R-HSA-5689880 Ub-specific processing proteases 0.754241 0.122
R-HSA-9764265 Regulation of CDH1 Expression and Function 0.754241 0.122
R-HSA-9764274 Regulation of Expression and Function of Type I Classical Cadherins 0.754241 0.122
R-HSA-2559583 Cellular Senescence 0.766573 0.115
R-HSA-9006931 Signaling by Nuclear Receptors 0.769655 0.114
R-HSA-201681 TCF dependent signaling in response to WNT 0.771669 0.113
R-HSA-2262752 Cellular responses to stress 0.773011 0.112
R-HSA-168249 Innate Immune System 0.773748 0.111
R-HSA-1266738 Developmental Biology 0.781329 0.107
R-HSA-422475 Axon guidance 0.783119 0.106
R-HSA-168898 Toll-like Receptor Cascades 0.784725 0.105
R-HSA-72163 mRNA Splicing - Major Pathway 0.789428 0.103
R-HSA-392499 Metabolism of proteins 0.789594 0.103
R-HSA-9759476 Regulation of Homotypic Cell-Cell Adhesion 0.792506 0.101
R-HSA-389948 Co-inhibition by PD-1 0.798530 0.098
R-HSA-948021 Transport to the Golgi and subsequent modification 0.801476 0.096
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.802933 0.095
R-HSA-1483206 Glycerophospholipid biosynthesis 0.802933 0.095
R-HSA-72172 mRNA Splicing 0.805816 0.094
R-HSA-397014 Muscle contraction 0.816934 0.088
R-HSA-9675108 Nervous system development 0.818040 0.087
R-HSA-68882 Mitotic Anaphase 0.822254 0.085
R-HSA-2555396 Mitotic Metaphase and Anaphase 0.823560 0.084
R-HSA-418990 Adherens junctions interactions 0.824856 0.084
R-HSA-8951664 Neddylation 0.828689 0.082
R-HSA-446203 Asparagine N-linked glycosylation 0.835186 0.078
R-HSA-9705683 SARS-CoV-2-host interactions 0.837312 0.077
R-HSA-8939211 ESR-mediated signaling 0.847769 0.072
R-HSA-157118 Signaling by NOTCH 0.851104 0.070
R-HSA-8953897 Cellular responses to stimuli 0.858073 0.066
R-HSA-5619115 Disorders of transmembrane transporters 0.858607 0.066
R-HSA-421270 Cell-cell junction organization 0.862725 0.064
R-HSA-162582 Signal Transduction 0.865329 0.063
R-HSA-199991 Membrane Trafficking 0.868616 0.061
R-HSA-597592 Post-translational protein modification 0.871923 0.060
R-HSA-112316 Neuronal System 0.873572 0.059
R-HSA-76002 Platelet activation, signaling and aggregation 0.884197 0.053
R-HSA-446728 Cell junction organization 0.887575 0.052
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.890856 0.050
R-HSA-5673001 RAF/MAP kinase cascade 0.896370 0.048
R-HSA-1257604 PIP3 activates AKT signaling 0.900876 0.045
R-HSA-5684996 MAPK1/MAPK3 signaling 0.901608 0.045
R-HSA-195721 Signaling by WNT 0.903056 0.044
R-HSA-1500931 Cell-Cell communication 0.915171 0.038
R-HSA-9679506 SARS-CoV Infections 0.924714 0.034
R-HSA-9824446 Viral Infection Pathways 0.925805 0.033
R-HSA-168256 Immune System 0.926039 0.033
R-HSA-9006925 Intracellular signaling by second messengers 0.930066 0.031
R-HSA-9694516 SARS-CoV-2 Infection 0.933613 0.030
R-HSA-5653656 Vesicle-mediated transport 0.943612 0.025
R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.948840 0.023
R-HSA-9824439 Bacterial Infection Pathways 0.951441 0.022
R-HSA-425407 SLC-mediated transmembrane transport 0.953911 0.020
R-HSA-71387 Metabolism of carbohydrates and carbohydrate derivatives 0.970122 0.013
R-HSA-382551 Transport of small molecules 0.978981 0.009
R-HSA-1643685 Disease 0.981807 0.008
R-HSA-1280218 Adaptive Immune System 0.985723 0.006
R-HSA-5663205 Infectious disease 0.988290 0.005
R-HSA-109582 Hemostasis 0.997522 0.001
R-HSA-556833 Metabolism of lipids 0.999143 0.000
R-HSA-9709957 Sensory Perception 0.999926 0.000
R-HSA-1430728 Metabolism 1.000000 0.000
Download
kinase JSD_mean pearson_surrounding kinase_max_IC_position max_position_JSD
JNK2JNK2 0.851 0.825 1 0.888
P38GP38G 0.850 0.816 1 0.911
HIPK2HIPK2 0.850 0.735 1 0.871
CDK17CDK17 0.846 0.792 1 0.903
DYRK4DYRK4 0.846 0.747 1 0.878
DYRK2DYRK2 0.846 0.726 1 0.800
CDK18CDK18 0.846 0.775 1 0.886
CDK8CDK8 0.844 0.759 1 0.848
ERK1ERK1 0.843 0.777 1 0.871
CDK7CDK7 0.843 0.757 1 0.851
CDK19CDK19 0.843 0.749 1 0.880
P38DP38D 0.842 0.787 1 0.919
DYRK1BDYRK1B 0.841 0.731 1 0.842
P38BP38B 0.841 0.772 1 0.850
JNK3JNK3 0.839 0.805 1 0.858
CDK1CDK1 0.839 0.756 1 0.861
KISKIS 0.838 0.690 1 0.828
CDK3CDK3 0.838 0.696 1 0.898
CDK12CDK12 0.837 0.766 1 0.884
CLK3CLK3 0.837 0.524 1 0.569
HIPK1HIPK1 0.837 0.682 1 0.788
CDK13CDK13 0.836 0.755 1 0.868
CDK16CDK16 0.836 0.755 1 0.895
P38AP38A 0.835 0.758 1 0.800
CDK14CDK14 0.834 0.766 1 0.861
ERK2ERK2 0.834 0.783 1 0.828
NLKNLK 0.831 0.707 1 0.622
CDK10CDK10 0.830 0.721 1 0.873
DYRK3DYRK3 0.829 0.594 1 0.753
CLK4CLK4 0.828 0.464 -3 0.702
HIPK3HIPK3 0.826 0.662 1 0.768
CDK5CDK5 0.826 0.709 1 0.827
CDK9CDK9 0.826 0.737 1 0.865
CLK1CLK1 0.826 0.468 -3 0.678
DYRK1ADYRK1A 0.824 0.585 1 0.768
JNK1JNK1 0.823 0.726 1 0.878
HIPK4HIPK4 0.822 0.439 1 0.607
CLK2CLK2 0.821 0.452 -3 0.676
CDK4CDK4 0.820 0.741 1 0.892
CDK6CDK6 0.817 0.712 1 0.878
SRPK1SRPK1 0.816 0.312 -3 0.669
ERK5ERK5 0.816 0.380 1 0.524
CDK2CDK2 0.812 0.585 1 0.758
ICKICK 0.809 0.358 -3 0.752
MAKMAK 0.807 0.477 -2 0.804
SRPK2SRPK2 0.804 0.248 -3 0.604
COTCOT 0.804 -0.025 2 0.892
MTORMTOR 0.804 0.189 1 0.414
PRP4PRP4 0.802 0.446 -3 0.719
CDKL1CDKL1 0.799 0.130 -3 0.723
CDKL5CDKL5 0.797 0.143 -3 0.711
MOKMOK 0.795 0.439 1 0.679
AURCAURC 0.795 0.171 -2 0.828
SRPK3SRPK3 0.794 0.203 -3 0.648
RSK2RSK2 0.794 0.063 -3 0.695
CAMLCKCAMLCK 0.794 0.110 -2 0.909
CDC7CDC7 0.793 -0.083 1 0.235
CAMK1BCAMK1B 0.793 0.028 -3 0.784
PIM3PIM3 0.793 -0.002 -3 0.755
MOSMOS 0.792 -0.028 1 0.286
SKMLCKSKMLCK 0.792 0.054 -2 0.909
PRPKPRPK 0.792 -0.092 -1 0.801
TBK1TBK1 0.792 -0.124 1 0.226
IKKBIKKB 0.791 -0.111 -2 0.705
IKKEIKKE 0.790 -0.127 1 0.221
RAF1RAF1 0.790 -0.135 1 0.249
PIM1PIM1 0.789 0.056 -3 0.709
P70S6KBP70S6KB 0.789 0.060 -3 0.717
RIPK3RIPK3 0.789 -0.060 3 0.762
AURBAURB 0.789 0.151 -2 0.824
PAK6PAK6 0.789 0.137 -2 0.861
DAPK2DAPK2 0.789 0.058 -3 0.784
PKACGPKACG 0.788 0.081 -2 0.846
WNK1WNK1 0.788 -0.021 -2 0.873
ATRATR 0.788 -0.045 1 0.295
BMPR2BMPR2 0.788 -0.139 -2 0.822
CAMK2GCAMK2G 0.787 -0.044 2 0.825
PAK1PAK1 0.787 0.094 -2 0.895
NDR1NDR1 0.787 0.006 -3 0.749
P90RSKP90RSK 0.787 0.030 -3 0.700
RSK3RSK3 0.786 0.038 -3 0.692
MST4MST4 0.786 -0.019 2 0.831
PDHK4PDHK4 0.785 -0.155 1 0.310
DSTYKDSTYK 0.785 -0.118 2 0.900
GCN2GCN2 0.785 -0.157 2 0.803
PAK3PAK3 0.785 0.070 -2 0.890
NIKNIK 0.785 -0.021 -3 0.797
PRKD2PRKD2 0.785 0.020 -3 0.685
PKN3PKN3 0.785 -0.036 -3 0.749
GRK1GRK1 0.784 0.004 -2 0.713
PKACBPKACB 0.784 0.132 -2 0.831
NDR2NDR2 0.784 -0.021 -3 0.753
ERK7ERK7 0.783 0.246 2 0.548
RSK4RSK4 0.783 0.074 -3 0.674
PKCDPKCD 0.783 0.009 2 0.788
GRK6GRK6 0.782 -0.040 1 0.232
PKG2PKG2 0.781 0.107 -2 0.822
ULK2ULK2 0.781 -0.191 2 0.791
TGFBR2TGFBR2 0.781 -0.081 -2 0.758
MNK2MNK2 0.781 0.078 -2 0.893
AURAAURA 0.781 0.132 -2 0.798
WNK3WNK3 0.780 -0.132 1 0.255
MLK1MLK1 0.780 -0.118 2 0.814
PAK2PAK2 0.780 0.073 -2 0.883
PKN2PKN2 0.780 -0.036 -3 0.749
NEK7NEK7 0.780 -0.156 -3 0.761
NUAK2NUAK2 0.780 -0.011 -3 0.768
CHAK2CHAK2 0.780 -0.061 -1 0.832
GRK5GRK5 0.780 -0.103 -3 0.798
PRKD1PRKD1 0.780 -0.038 -3 0.720
PRKXPRKX 0.780 0.134 -3 0.625
IKKAIKKA 0.780 -0.062 -2 0.678
MSK1MSK1 0.779 0.082 -3 0.662
MSK2MSK2 0.779 0.043 -3 0.660
MYLK4MYLK4 0.779 0.082 -2 0.884
BMPR1BBMPR1B 0.779 -0.007 1 0.200
PDHK1PDHK1 0.778 -0.199 1 0.293
RIPK1RIPK1 0.778 -0.122 1 0.241
GRK7GRK7 0.778 0.034 1 0.251
NEK6NEK6 0.778 -0.096 -2 0.795
ALK4ALK4 0.778 -0.019 -2 0.774
ATMATM 0.777 -0.049 1 0.254
AKT2AKT2 0.777 0.080 -3 0.624
SGK3SGK3 0.777 0.062 -3 0.679
PKRPKR 0.777 -0.030 1 0.271
MAPKAPK3MAPKAPK3 0.776 -0.058 -3 0.681
TGFBR1TGFBR1 0.776 -0.019 -2 0.742
ANKRD3ANKRD3 0.776 -0.128 1 0.270
PRKD3PRKD3 0.776 0.011 -3 0.661
DNAPKDNAPK 0.776 -0.024 1 0.280
GSK3AGSK3A 0.776 0.228 4 0.555
MNK1MNK1 0.775 0.071 -2 0.891
CAMK4CAMK4 0.775 -0.038 -3 0.745
PIM2PIM2 0.774 0.056 -3 0.675
LATS1LATS1 0.774 0.004 -3 0.762
DLKDLK 0.773 -0.166 1 0.252
ULK1ULK1 0.773 -0.162 -3 0.747
PAK5PAK5 0.773 0.112 -2 0.814
PLK1PLK1 0.773 -0.091 -2 0.749
MLK3MLK3 0.772 -0.062 2 0.744
NEK9NEK9 0.772 -0.190 2 0.832
CAMK2DCAMK2D 0.772 -0.107 -3 0.746
AMPKA1AMPKA1 0.771 -0.078 -3 0.766
FAM20CFAM20C 0.771 0.048 2 0.697
TTBK2TTBK2 0.771 -0.143 2 0.713
ALK2ALK2 0.771 -0.028 -2 0.746
ACVR2AACVR2A 0.771 -0.048 -2 0.736
VRK2VRK2 0.770 -0.002 1 0.353
MEK1MEK1 0.770 -0.088 2 0.865
PKACAPKACA 0.770 0.111 -2 0.800
LATS2LATS2 0.770 -0.062 -5 0.738
MAPKAPK2MAPKAPK2 0.770 -0.041 -3 0.649
PAK4PAK4 0.770 0.122 -2 0.820
AKT1AKT1 0.770 0.080 -3 0.635
TSSK2TSSK2 0.770 -0.074 -5 0.810
ACVR2BACVR2B 0.770 -0.053 -2 0.746
MLK2MLK2 0.770 -0.159 2 0.832
IRE1IRE1 0.770 -0.104 1 0.246
BMPR1ABMPR1A 0.769 -0.001 1 0.188
BCKDKBCKDK 0.769 -0.167 -1 0.731
PLK3PLK3 0.769 -0.045 2 0.787
PINK1PINK1 0.769 0.138 1 0.451
MARK4MARK4 0.769 -0.107 4 0.834
HUNKHUNK 0.769 -0.155 2 0.799
CAMK2BCAMK2B 0.768 -0.043 2 0.819
TSSK1TSSK1 0.768 -0.055 -3 0.778
MASTLMASTL 0.768 -0.223 -2 0.767
SMMLCKSMMLCK 0.768 0.064 -3 0.733
GRK4GRK4 0.768 -0.124 -2 0.730
PKCGPKCG 0.767 -0.019 2 0.735
PKCAPKCA 0.767 -0.016 2 0.722
NEK2NEK2 0.766 -0.113 2 0.810
SMG1SMG1 0.766 -0.074 1 0.280
CAMK2ACAMK2A 0.766 -0.024 2 0.821
MELKMELK 0.766 -0.075 -3 0.715
PKCZPKCZ 0.765 -0.032 2 0.784
AMPKA2AMPKA2 0.765 -0.067 -3 0.735
MLK4MLK4 0.765 -0.083 2 0.735
PHKG1PHKG1 0.765 -0.079 -3 0.740
NIM1NIM1 0.765 -0.107 3 0.756
PKCBPKCB 0.764 -0.038 2 0.741
DRAK1DRAK1 0.764 -0.101 1 0.193
DAPK3DAPK3 0.764 0.081 -3 0.723
PKCHPKCH 0.764 -0.034 2 0.719
MPSK1MPSK1 0.763 0.008 1 0.322
SGK1SGK1 0.763 0.089 -3 0.547
WNK4WNK4 0.763 -0.077 -2 0.855
P70S6KP70S6K 0.762 0.007 -3 0.631
YSK4YSK4 0.762 -0.184 1 0.226
IRE2IRE2 0.762 -0.108 2 0.734
TLK2TLK2 0.761 -0.124 1 0.236
GSK3BGSK3B 0.761 0.086 4 0.547
MAPKAPK5MAPKAPK5 0.761 -0.078 -3 0.627
QIKQIK 0.761 -0.111 -3 0.755
PERKPERK 0.760 -0.132 -2 0.782
MEKK3MEKK3 0.760 -0.126 1 0.252
CHAK1CHAK1 0.760 -0.150 2 0.779
DAPK1DAPK1 0.759 0.075 -3 0.710
AKT3AKT3 0.759 0.076 -3 0.560
GRK2GRK2 0.759 -0.069 -2 0.634
CHK1CHK1 0.759 -0.081 -3 0.752
NUAK1NUAK1 0.759 -0.073 -3 0.713
GAKGAK 0.758 0.003 1 0.316
MRCKBMRCKB 0.758 0.087 -3 0.663
MEK5MEK5 0.758 -0.143 2 0.837
MEKK1MEKK1 0.758 -0.149 1 0.266
HRIHRI 0.758 -0.166 -2 0.803
PKCIPKCI 0.758 0.016 2 0.745
IRAK4IRAK4 0.758 -0.104 1 0.238
CAMK1GCAMK1G 0.758 -0.038 -3 0.683
DCAMKL1DCAMKL1 0.757 -0.050 -3 0.708
QSKQSK 0.757 -0.075 4 0.806
BRAFBRAF 0.757 -0.117 -4 0.768
MST3MST3 0.757 -0.065 2 0.822
MEKK2MEKK2 0.757 -0.109 2 0.816
MRCKAMRCKA 0.757 0.077 -3 0.679
PKCTPKCT 0.756 -0.020 2 0.730
TAO3TAO3 0.756 -0.061 1 0.272
PLK4PLK4 0.755 -0.133 2 0.624
DCAMKL2DCAMKL2 0.755 -0.047 -3 0.733
ZAKZAK 0.755 -0.160 1 0.233
DMPK1DMPK1 0.755 0.127 -3 0.689
HASPINHASPIN 0.754 0.111 -1 0.815
ROCK2ROCK2 0.754 0.071 -3 0.707
SIKSIK 0.754 -0.078 -3 0.690
PASKPASK 0.753 -0.052 -3 0.775
NEK5NEK5 0.753 -0.165 1 0.255
PHKG2PHKG2 0.753 -0.064 -3 0.722
BRSK1BRSK1 0.753 -0.084 -3 0.706
TLK1TLK1 0.753 -0.142 -2 0.749
SBKSBK 0.752 0.101 -3 0.512
PDK1PDK1 0.752 -0.067 1 0.276
CK1ECK1E 0.752 -0.006 -3 0.579
MARK2MARK2 0.751 -0.085 4 0.733
CAMK1DCAMK1D 0.751 -0.014 -3 0.617
TTBK1TTBK1 0.751 -0.129 2 0.623
PKCEPKCE 0.751 0.022 2 0.710
MARK3MARK3 0.750 -0.079 4 0.769
CK1DCK1D 0.750 0.018 -3 0.528
CK1A2CK1A2 0.750 0.015 -3 0.529
BUB1BUB1 0.750 0.038 -5 0.773
TAO2TAO2 0.750 -0.082 2 0.838
PLK2PLK2 0.749 0.019 -3 0.835
BRSK2BRSK2 0.749 -0.126 -3 0.726
SSTKSSTK 0.749 -0.053 4 0.788
SNRKSNRK 0.748 -0.157 2 0.672
CK2A2CK2A2 0.748 -0.020 1 0.162
PKN1PKN1 0.748 -0.026 -3 0.647
PKG1PKG1 0.747 0.074 -2 0.769
MARK1MARK1 0.747 -0.105 4 0.789
LOKLOK 0.747 -0.051 -2 0.790
LKB1LKB1 0.747 -0.075 -3 0.747
NEK8NEK8 0.747 -0.143 2 0.805
GRK3GRK3 0.747 -0.064 -2 0.587
CHK2CHK2 0.746 -0.012 -3 0.574
CAMKK1CAMKK1 0.746 -0.171 -2 0.741
NEK11NEK11 0.746 -0.167 1 0.265
IRAK1IRAK1 0.746 -0.185 -1 0.788
TAK1TAK1 0.744 -0.142 1 0.238
PBKPBK 0.743 -0.029 1 0.296
ROCK1ROCK1 0.743 0.070 -3 0.676
CAMKK2CAMKK2 0.743 -0.149 -2 0.759
CRIKCRIK 0.743 0.053 -3 0.632
SLKSLK 0.743 -0.060 -2 0.718
GCKGCK 0.743 -0.116 1 0.261
NEK4NEK4 0.742 -0.172 1 0.248
HPK1HPK1 0.742 -0.089 1 0.259
CK1G1CK1G1 0.742 -0.038 -3 0.561
LRRK2LRRK2 0.741 -0.062 2 0.837
TNIKTNIK 0.741 -0.084 3 0.804
CK2A1CK2A1 0.741 -0.024 1 0.149
MINKMINK 0.740 -0.148 1 0.241
HGKHGK 0.740 -0.126 3 0.802
CAMK1ACAMK1A 0.740 -0.006 -3 0.585
MEKK6MEKK6 0.739 -0.145 1 0.257
MAP3K15MAP3K15 0.739 -0.148 1 0.246
MST2MST2 0.739 -0.164 1 0.246
RIPK2RIPK2 0.738 -0.181 1 0.214
BIKEBIKE 0.738 -0.011 1 0.307
NEK1NEK1 0.738 -0.172 1 0.240
MEK2MEK2 0.736 -0.161 2 0.830
KHS2KHS2 0.736 -0.056 1 0.269
VRK1VRK1 0.735 -0.189 2 0.831
KHS1KHS1 0.735 -0.093 1 0.256
STK33STK33 0.733 -0.115 2 0.618
YSK1YSK1 0.732 -0.136 2 0.798
EEF2KEEF2K 0.732 -0.138 3 0.763
MST1MST1 0.731 -0.175 1 0.236
TTKTTK 0.731 -0.052 -2 0.763
AAK1AAK1 0.730 0.014 1 0.305
NEK3NEK3 0.729 -0.140 1 0.260
PDHK3_TYRPDHK3_TYR 0.726 0.146 4 0.920
OSR1OSR1 0.725 -0.090 2 0.820
TAO1TAO1 0.724 -0.101 1 0.241
ALPHAK3ALPHAK3 0.724 -0.053 -1 0.728
ASK1ASK1 0.723 -0.142 1 0.240
MYO3BMYO3B 0.720 -0.101 2 0.813
YANK3YANK3 0.718 -0.039 2 0.405
MYO3AMYO3A 0.717 -0.118 1 0.259
PDHK4_TYRPDHK4_TYR 0.717 0.060 2 0.886
TESK1_TYRTESK1_TYR 0.716 0.014 3 0.839
LIMK2_TYRLIMK2_TYR 0.716 0.095 -3 0.792
PKMYT1_TYRPKMYT1_TYR 0.715 0.065 3 0.840
MAP2K4_TYRMAP2K4_TYR 0.712 -0.034 -1 0.802
BMPR2_TYRBMPR2_TYR 0.712 0.022 -1 0.809
MAP2K7_TYRMAP2K7_TYR 0.712 -0.066 2 0.855
RETRET 0.712 -0.063 1 0.270
MAP2K6_TYRMAP2K6_TYR 0.711 0.004 -1 0.796
PDHK1_TYRPDHK1_TYR 0.711 -0.035 -1 0.829
YES1YES1 0.710 0.006 -1 0.869
PINK1_TYRPINK1_TYR 0.710 -0.084 1 0.293
TXKTXK 0.709 -0.002 1 0.221
MST1RMST1R 0.708 -0.059 3 0.834
EPHA6EPHA6 0.708 -0.052 -1 0.838
STLK3STLK3 0.707 -0.178 1 0.220
CSF1RCSF1R 0.707 -0.043 3 0.817
EPHB4EPHB4 0.706 -0.070 -1 0.821
ABL2ABL2 0.706 -0.047 -1 0.830
TNK2TNK2 0.705 -0.032 3 0.821
CK1ACK1A 0.704 -0.033 -3 0.448
JAK2JAK2 0.704 -0.111 1 0.280
LIMK1_TYRLIMK1_TYR 0.704 -0.034 2 0.847
BLKBLK 0.703 -0.002 -1 0.864
ABL1ABL1 0.703 -0.052 -1 0.833
LCKLCK 0.703 -0.030 -1 0.854
FGFR2FGFR2 0.702 0.002 3 0.814
SRMSSRMS 0.702 -0.077 1 0.219
TYRO3TYRO3 0.701 -0.122 3 0.804
TYK2TYK2 0.700 -0.203 1 0.259
HCKHCK 0.700 -0.077 -1 0.855
DDR1DDR1 0.700 -0.094 4 0.824
FYNFYN 0.699 0.001 -1 0.841
NEK10_TYRNEK10_TYR 0.699 -0.101 1 0.230
TECTEC 0.699 -0.035 -1 0.826
KITKIT 0.699 -0.067 3 0.818
EPHB1EPHB1 0.699 -0.098 1 0.219
TNK1TNK1 0.699 -0.027 3 0.788
EPHA4EPHA4 0.698 -0.054 2 0.775
KDRKDR 0.698 -0.044 3 0.799
TEKTEK 0.698 0.005 3 0.768
FGFR1FGFR1 0.698 -0.020 3 0.804
ROS1ROS1 0.698 -0.145 3 0.783
INSRRINSRR 0.697 -0.088 3 0.770
JAK1JAK1 0.697 -0.089 1 0.246
JAK3JAK3 0.696 -0.122 1 0.248
EPHB2EPHB2 0.696 -0.086 -1 0.809
MERTKMERTK 0.696 -0.081 3 0.804
FERFER 0.696 -0.139 1 0.249
AXLAXL 0.695 -0.097 3 0.808
CK1G3CK1G3 0.695 -0.022 -3 0.405
EPHA7EPHA7 0.695 -0.058 2 0.777
DDR2DDR2 0.695 0.009 3 0.782
FGRFGR 0.695 -0.151 1 0.250
ITKITK 0.695 -0.107 -1 0.833
BMXBMX 0.695 -0.068 -1 0.778
METMET 0.695 -0.060 3 0.822
FLT3FLT3 0.694 -0.123 3 0.808
PDGFRBPDGFRB 0.694 -0.149 3 0.821
EPHB3EPHB3 0.694 -0.118 -1 0.819
FGFR3FGFR3 0.693 -0.018 3 0.797
BTKBTK 0.692 -0.129 -1 0.823
EPHA1EPHA1 0.691 -0.076 3 0.810
LTKLTK 0.691 -0.092 3 0.790
PTK2BPTK2B 0.691 -0.032 -1 0.838
LYNLYN 0.690 -0.054 3 0.754
SRCSRC 0.690 -0.031 -1 0.854
ALKALK 0.689 -0.100 3 0.769
EPHA8EPHA8 0.688 -0.046 -1 0.823
FRKFRK 0.688 -0.087 -1 0.867
WEE1_TYRWEE1_TYR 0.687 -0.085 -1 0.754
PDGFRAPDGFRA 0.687 -0.178 3 0.822
ERBB2ERBB2 0.687 -0.119 1 0.228
FGFR4FGFR4 0.687 -0.041 -1 0.752
FLT1FLT1 0.686 -0.106 -1 0.782
EGFREGFR 0.686 -0.067 1 0.191
EPHA3EPHA3 0.685 -0.106 2 0.744
NTRK1NTRK1 0.685 -0.164 -1 0.774
PTK6PTK6 0.685 -0.152 -1 0.772
TNNI3K_TYRTNNI3K_TYR 0.684 -0.113 1 0.294
EPHA5EPHA5 0.684 -0.083 2 0.765
FLT4FLT4 0.684 -0.120 3 0.779
MATKMATK 0.683 -0.062 -1 0.755
NTRK2NTRK2 0.683 -0.161 3 0.793
YANK2YANK2 0.682 -0.071 2 0.428
CSKCSK 0.682 -0.083 2 0.777
NTRK3NTRK3 0.680 -0.132 -1 0.726
INSRINSR 0.680 -0.143 3 0.747
PTK2PTK2 0.679 -0.030 -1 0.747
ERBB4ERBB4 0.677 -0.052 1 0.192
EPHA2EPHA2 0.676 -0.078 -1 0.772
SYKSYK 0.674 -0.059 -1 0.733
CK1G2CK1G2 0.669 -0.049 -3 0.489
MUSKMUSK 0.668 -0.144 1 0.176
IGF1RIGF1R 0.666 -0.124 3 0.698
FESFES 0.665 -0.084 -1 0.762
ZAP70ZAP70 0.654 -0.064 -1 0.664