Motif 1042 (n=106)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A6NKT7 | RGPD3 | T1475 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NMY6 | ANXA2P2 | T105 | ochoa | Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. {ECO:0000250}. |
| O00148 | DDX39A | T171 | ochoa | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}. |
| O14562 | UBFD1 | T165 | ochoa | Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog) | May play a role as NF-kappa-B regulator. {ECO:0000269|PubMed:19285159}. |
| O14715 | RGPD8 | T1474 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15014 | ZNF609 | T746 | ochoa | Zinc finger protein 609 | Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.; FUNCTION: [Isoform 2]: Involved in the regulation of myoblast proliferation during myogenesis. {ECO:0000269|PubMed:28344082}. |
| O60271 | SPAG9 | T586 | ochoa|psp | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {ECO:0000250|UniProtKB:Q58A65, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:29146937}. |
| O60293 | ZFC3H1 | T766 | ochoa | Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2) | Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}. |
| O75449 | KATNA1 | T81 | ochoa | Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin) | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}. |
| O75781 | PALM | T145 | ochoa | Paralemmin-1 (Paralemmin) | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269|PubMed:14978216}. |
| O94830 | DDHD2 | T184 | ochoa | Triacylglycerol hydrolase DDHD2 (TAG hydrolase) (EC 3.1.1.3) (DDHD domain-containing protein 2) (KIAA0725p) (Phospholipase DDHD2) (EC 3.1.1.-) (SAM, WWE and DDHD domain-containing protein 1) (Triglyceride hydrolase DDHD2) (Triglyceride lipase) | Diacylglycerol (DAG) and triacylglycerol (TAG) lipase required for proper lipid homeostasis in the central nervous system (PubMed:29278326, PubMed:37832604). It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3 DAG downstream of PNPLA2/ATGL (By similarity). In vitro, it also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. {ECO:0000250|UniProtKB:Q80Y98, ECO:0000269|PubMed:11788596, ECO:0000269|PubMed:20932832, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:29278326, ECO:0000269|PubMed:37832604}. |
| O94986 | CEP152 | T1351 | ochoa | Centrosomal protein of 152 kDa (Cep152) | Necessary for centrosome duplication; the function also seems to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CPAP, 2 molecules involved in centriole formation (PubMed:20852615, PubMed:21059844). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615). {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}. |
| O95149 | SNUPN | T341 | ochoa | Snurportin-1 (RNA U transporter 1) | Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472, ECO:0000269|PubMed:16030253, ECO:0000269|PubMed:38413582, ECO:0000269|PubMed:9670026}. |
| P04049 | RAF1 | T260 | ochoa|psp | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P07355 | ANXA2 | T105 | ochoa | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity). {ECO:0000250|UniProtKB:P07356, ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. {ECO:0000269|PubMed:25139904}. |
| P0DJD0 | RGPD1 | T1459 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T1467 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10276 | RARA | T181 | psp | Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) | Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758). {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:16417524, ECO:0000269|PubMed:19398580, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:21152046, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9267036}. |
| P17480 | UBTF | T208 | ochoa | Nucleolar transcription factor 1 (Autoantigen NOR-90) (Upstream-binding factor 1) (UBF-1) | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11283244, ECO:0000269|PubMed:16858408, ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. |
| P18206 | VCL | T672 | ochoa | Vinculin (Metavinculin) (MV) | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}. |
| P27816 | MAP4 | T917 | ochoa|psp | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P35251 | RFC1 | T506 | ochoa|psp | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (PubMed:9488738). This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859, ECO:0000269|PubMed:9488738}. |
| P35609 | ACTN2 | T237 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P36405 | ARL3 | T46 | ochoa | ADP-ribosylation factor-like protein 3 | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). {ECO:0000250|UniProtKB:Q9WUL7, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}. |
| P46013 | MKI67 | T1111 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1233 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1355 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1476 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1719 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1841 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T1963 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2085 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2203 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2325 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46013 | MKI67 | T2927 | ochoa | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67) | Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636). {ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551, ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226, ECO:0000269|PubMed:28935370, ECO:0000269|PubMed:32879492, ECO:0000269|PubMed:35513709, ECO:0000269|PubMed:39153474}. |
| P46087 | NOP2 | T727 | ochoa | 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}. |
| P49792 | RANBP2 | T2450 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49916 | LIG3 | T204 | ochoa | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
| P51649 | ALDH5A1 | T181 | psp | Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase) | Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). {ECO:0000269|PubMed:19300440}. |
| P62191 | PSMC1 | T53 | ochoa | 26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1) | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. |
| Q03188 | CENPC | T734 | ochoa|psp | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q08043 | ACTN3 | T244 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q08999 | RBL2 | T401 | ochoa|psp | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Q09666 | AHNAK | T3366 | ochoa | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | May be required for neuronal cell differentiation. |
| Q12800 | TFCP2 | T258 | psp | Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF) | Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:8035790, ECO:0000269|PubMed:8157699}. |
| Q13177 | PAK2 | T83 | ochoa | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:12853446, PubMed:16617111, PubMed:9171063). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111, ECO:0000269|PubMed:19273597, ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21555521, ECO:0000269|PubMed:21724829, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:33693784, ECO:0000269|PubMed:7744004, ECO:0000269|PubMed:9171063}. |
| Q13422 | IKZF1 | T291 | ochoa | DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1) | Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067, ECO:0000269|PubMed:19141594}. |
| Q13838 | DDX39B | T172 | ochoa | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | Involved in nuclear export of spliced and unspliced mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). The THOC1-THOC2-THOC3 core complex alone is sufficient to promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). Associates with SARNP/CIP29, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export (PubMed:37578863). May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC4 and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:33191911, ECO:0000269|PubMed:37578863, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. |
| Q14680 | MELK | T466 | ochoa | Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) | Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. {ECO:0000269|PubMed:11802789, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:14699119, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:16216881, ECO:0000269|PubMed:17280616}. |
| Q14CS0 | UBXN2B | T59 | psp | UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37) | Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807). {ECO:0000269|PubMed:17141156, ECO:0000269|PubMed:23649807}. |
| Q15059 | BRD3 | T257 | ochoa | Bromodomain-containing protein 3 (RING3-like protein) | Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}. |
| Q15334 | LLGL1 | T704 | ochoa | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}. |
| Q4FZB7 | KMT5B | T630 | ochoa | Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) | Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q3U8K7, ECO:0000269|PubMed:23720823, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}. |
| Q5JSP0 | FGD3 | T549 | ochoa | FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5) | Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}. |
| Q5M775 | SPECC1 | T338 | ochoa | Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1) | None |
| Q5QJE6 | DNTTIP2 | T232 | ochoa | Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2) | Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147, ECO:0000269|PubMed:34516797}. |
| Q5T5P2 | KIAA1217 | T613 | ochoa | Sickle tail protein homolog | Required for normal development of intervertebral disks. {ECO:0000250|UniProtKB:A2AQ25}. |
| Q6P4F7 | ARHGAP11A | T306 | ochoa | Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269|PubMed:27957544}. |
| Q6PKG0 | LARP1 | T649 | ochoa|psp | La-related protein 1 (La ribonucleoprotein domain family member 1) | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:26206669, PubMed:28379136, PubMed:28650797, PubMed:29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28379136, PubMed:28650797, PubMed:29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714, ECO:0000269|PubMed:25940091, ECO:0000269|PubMed:26206669, ECO:0000269|PubMed:28379136, ECO:0000269|PubMed:28650797, ECO:0000269|PubMed:28673543, ECO:0000269|PubMed:29244122}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}. |
| Q6VY07 | PACS1 | T504 | ochoa | Phosphofurin acidic cluster sorting protein 1 (PACS-1) | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250|UniProtKB:Q8K212, ECO:0000269|PubMed:11331585, ECO:0000269|PubMed:15692563}. |
| Q6WKZ4 | RAB11FIP1 | T229 | ochoa | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. Interaction with RAB14 may function in the process of neurite formation (PubMed:26032412). {ECO:0000269|PubMed:11786538, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:15355514, ECO:0000269|PubMed:16920206, ECO:0000269|PubMed:26032412}. |
| Q6Y7W6 | GIGYF2 | T370 | ochoa | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631, PubMed:35878012). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide (PubMed:32726578). GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (PubMed:32726578). {ECO:0000269|PubMed:12771153, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:31439631, ECO:0000269|PubMed:32726578, ECO:0000269|PubMed:35878012}.; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. {ECO:0000269|PubMed:35878012}. |
| Q76NI1 | KNDC1 | T265 | ochoa | Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2) | RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). {ECO:0000250|UniProtKB:Q0KK55, ECO:0000269|PubMed:24788352}. |
| Q7Z3J3 | RGPD4 | T1475 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q86TI0 | TBC1D1 | T652 | ochoa | TBC1 domain family member 1 | May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}. |
| Q86YT9 | JAML | T261 | ochoa | Junctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1) | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}. |
| Q86Z02 | HIPK1 | T351 | ochoa | Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). {ECO:0000269|PubMed:12702766, ECO:0000269|PubMed:12968034, ECO:0000269|PubMed:15701637, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:19646965, ECO:0000269|PubMed:24559171}. |
| Q8N1F7 | NUP93 | T236 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N3K9 | CMYA5 | T201 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8NEY1 | NAV1 | T1370 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8TEW0 | PARD3 | T579 | ochoa | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). {ECO:0000250|UniProtKB:Q99NH2, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:10934474, ECO:0000269|PubMed:10954424, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:27925688}. |
| Q8WWK9 | CKAP2 | T127 | ochoa | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q8WWK9 | CKAP2 | T623 | psp | Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}. |
| Q8WYP5 | AHCTF1 | T1257 | ochoa | Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) | Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:17235358}. |
| Q92539 | LPIN2 | T291 | ochoa | Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000250|UniProtKB:Q99PI5}. |
| Q92610 | ZNF592 | T1024 | ochoa | Zinc finger protein 592 | May be involved in transcriptional regulation. {ECO:0000269|PubMed:20531441}. |
| Q96KM6 | ZNF512B | T852 | ochoa | Zinc finger protein 512B | Involved in transcriptional regulation by repressing gene expression (PubMed:39460621). Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:39460621). {ECO:0000269|PubMed:39460621}. |
| Q96LT9 | RNPC3 | T291 | ochoa | RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K) | Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. {ECO:0000269|PubMed:16096647, ECO:0000269|PubMed:19447915, ECO:0000269|PubMed:24480542, ECO:0000269|PubMed:29255062}. |
| Q96LX8 | ZNF597 | T109 | ochoa | Zinc finger protein 597 | May be involved in transcriptional regulation. |
| Q96NA2 | RILP | T308 | ochoa | Rab-interacting lysosomal protein | Rab effector playing a role in late endocytic transport to degradative compartments (PubMed:11179213, PubMed:11696325, PubMed:12944476, PubMed:14668488, PubMed:27113757). Involved in the regulation of lysosomal morphology and distribution (PubMed:14668488, PubMed:27113757). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (PubMed:11179213, PubMed:11696325). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (PubMed:12944476). {ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:11696325, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14668488, ECO:0000269|PubMed:27113757}. |
| Q99666 | RGPD5 | T1474 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BQG0 | MYBBP1A | T1196 | ochoa | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q9BYG3 | NIFK | T223 | ochoa | MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK) | None |
| Q9H0H5 | RACGAP1 | T588 | ochoa | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:14729465, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16129829, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18511905, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19468302, ECO:0000269|PubMed:23235882, ECO:0000269|PubMed:9497316}. |
| Q9H1E3 | NUCKS1 | T202 | ochoa | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1) | Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318). {ECO:0000269|PubMed:26323318}. |
| Q9H1H9 | KIF13A | T1385 | ochoa | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}. |
| Q9H2X6 | HIPK2 | T360 | ochoa|psp | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. In response to DNA damage, phosphorylates DAZAP2 which localizes DAZAP2 to the nucleus, reduces interaction of DAZAP2 with HIPK2 and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent proteasomal degradation (PubMed:33591310). Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850, ECO:0000269|PubMed:33591310}. |
| Q9H422 | HIPK3 | T358 | ochoa | Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1) | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}. |
| Q9H7N4 | SCAF1 | T849 | ochoa | Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1) | May function in pre-mRNA splicing. {ECO:0000250}. |
| Q9H8U3 | ZFAND3 | T112 | ochoa | AN1-type zinc finger protein 3 (Testis-expressed protein 27) | None |
| Q9HCK8 | CHD8 | T537 | ochoa | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) | ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP (PubMed:28533432). Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692, ECO:0000269|PubMed:28533432, ECO:0000269|PubMed:36537238}. |
| Q9NQW7 | XPNPEP1 | T435 | ochoa | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11106490, PubMed:18515364, PubMed:35165443). Contributes to the degradation of bradykinin (PubMed:11106490). {ECO:0000269|PubMed:11106490, ECO:0000269|PubMed:18515364, ECO:0000269|PubMed:35165443}. |
| Q9NSY1 | BMP2K | T1137 | ochoa | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | May be involved in osteoblast differentiation. {ECO:0000250|UniProtKB:Q91Z96}. |
| Q9P2E9 | RRBP1 | T225 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9P2E9 | RRBP1 | T275 | ochoa | Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) | Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}. |
| Q9UHI6 | DDX20 | T688 | ochoa | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}. |
| Q9Y2H0 | DLGAP4 | T915 | ochoa | Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4) | May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. |
| Q9Y3Y2 | CHTOP | T33 | ochoa | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}. |
| Q9Y4F5 | CEP170B | T485 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y4F5 | CEP170B | T1117 | ochoa | Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) | Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}. |
| Q9Y6M5 | SLC30A1 | T462 | ochoa | Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1) | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444). Forms a complex with TMC6/EVER1 and TMC8/EVER2 at the ER membrane of keratynocytes which facilitates zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). {ECO:0000250|UniProtKB:Q62720, ECO:0000269|PubMed:18158319, ECO:0000269|PubMed:31471319, ECO:0000269|PubMed:32441444}. |
| Q13153 | PAK1 | T84 | SIGNOR|iPTMNet|EPSD | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:10551809, PubMed:11896197, PubMed:12876277, PubMed:14585966, PubMed:15611088, PubMed:17726028, PubMed:17989089, PubMed:30290153, PubMed:17420447). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (PubMed:8805275, PubMed:9528787). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (PubMed:8805275, PubMed:9528787). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (PubMed:9032240, PubMed:9395435). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (PubMed:15831477). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (PubMed:22669945). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (PubMed:12624090). Phosphorylates MYL9/MLC2 (By similarity). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (PubMed:11733498). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (PubMed:15833848). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (PubMed:25766321). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (PubMed:23260667). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (PubMed:27012601). Phosphorylates FXR1, promoting its localization to stress granules and activity (PubMed:20417602). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (PubMed:17420447). {ECO:0000250|UniProtKB:O88643, ECO:0000250|UniProtKB:P35465, ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:11896197, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966, ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:17420447, ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089, ECO:0000269|PubMed:20417602, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:27012601, ECO:0000269|PubMed:30290153, ECO:0000269|PubMed:8805275, ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435, ECO:0000269|PubMed:9528787}. |
| Q14204 | DYNC1H1 | T4221 | Sugiyama | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| P48735 | IDH2 | T197 | SIGNOR | Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | Plays a role in intermediary metabolism and energy production (PubMed:19228619, PubMed:22416140). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:19228619, PubMed:22416140). {ECO:0000269|PubMed:19228619, ECO:0000269|PubMed:22416140}. |
| Q05209 | PTPN12 | T81 | Sugiyama | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}. |
| P07195 | LDHB | T75 | Sugiyama | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). {ECO:0000269|PubMed:27618187}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.000205 | 3.689 |
| R-HSA-397014 | Muscle contraction | 0.000150 | 3.824 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.000331 | 3.480 |
| R-HSA-191859 | snRNP Assembly | 0.001025 | 2.989 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.001025 | 2.989 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.000726 | 3.139 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.001052 | 2.978 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.001403 | 2.853 |
| R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell dif... | 0.001641 | 2.785 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.002196 | 2.658 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.002329 | 2.633 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.003476 | 2.459 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.003476 | 2.459 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.003744 | 2.427 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.006216 | 2.207 |
| R-HSA-428540 | Activation of RAC1 | 0.004445 | 2.352 |
| R-HSA-68882 | Mitotic Anaphase | 0.004643 | 2.333 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.004738 | 2.324 |
| R-HSA-68886 | M Phase | 0.005006 | 2.300 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.005119 | 2.291 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 0.005661 | 2.247 |
| R-HSA-5578768 | Physiological factors | 0.006320 | 2.199 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.006320 | 2.199 |
| R-HSA-72187 | mRNA 3'-end processing | 0.007309 | 2.136 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.007012 | 2.154 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.007007 | 2.154 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.008356 | 2.078 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.009079 | 2.042 |
| R-HSA-3928664 | Ephrin signaling | 0.010104 | 1.996 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.010659 | 1.972 |
| R-HSA-211728 | Regulation of PAK-2p34 activity by PS-GAP/RHG10 | 0.012957 | 1.887 |
| R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | 0.013691 | 1.864 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.013871 | 1.858 |
| R-HSA-68877 | Mitotic Prometaphase | 0.012911 | 1.889 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.012088 | 1.918 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.013691 | 1.864 |
| R-HSA-373753 | Nephrin family interactions | 0.011837 | 1.927 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.015662 | 1.805 |
| R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 | 0.025748 | 1.589 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.023437 | 1.630 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.024654 | 1.608 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.024654 | 1.608 |
| R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.024654 | 1.608 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.027163 | 1.566 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.027163 | 1.566 |
| R-HSA-390522 | Striated Muscle Contraction | 0.028455 | 1.546 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.028455 | 1.546 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.031110 | 1.507 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.036701 | 1.435 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.038155 | 1.418 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.041127 | 1.386 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.041127 | 1.386 |
| R-HSA-169911 | Regulation of Apoptosis | 0.031110 | 1.507 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.033860 | 1.470 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.031110 | 1.507 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.033860 | 1.470 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.018831 | 1.725 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.028455 | 1.546 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.039630 | 1.402 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.029771 | 1.526 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.039630 | 1.402 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.038155 | 1.418 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.038155 | 1.418 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.039630 | 1.402 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.033469 | 1.475 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.035269 | 1.453 |
| R-HSA-1640170 | Cell Cycle | 0.020922 | 1.679 |
| R-HSA-8953854 | Metabolism of RNA | 0.024082 | 1.618 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.036701 | 1.435 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.035938 | 1.444 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.023348 | 1.632 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.036283 | 1.440 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.023437 | 1.630 |
| R-HSA-162906 | HIV Infection | 0.023241 | 1.634 |
| R-HSA-202433 | Generation of second messenger molecules | 0.038155 | 1.418 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.048922 | 1.310 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.048922 | 1.310 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.048922 | 1.310 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.048922 | 1.310 |
| R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium | 0.044627 | 1.350 |
| R-HSA-110381 | Resolution of AP sites via the single-nucleotide replacement pathway | 0.044627 | 1.350 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.047323 | 1.325 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.050839 | 1.294 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.047323 | 1.325 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.048922 | 1.310 |
| R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family | 0.044627 | 1.350 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.052178 | 1.283 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.045743 | 1.340 |
| R-HSA-202403 | TCR signaling | 0.046123 | 1.336 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.043396 | 1.363 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.043396 | 1.363 |
| R-HSA-164944 | Nef and signal transduction | 0.057011 | 1.244 |
| R-HSA-68875 | Mitotic Prophase | 0.057853 | 1.238 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.060986 | 1.215 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.063144 | 1.200 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.063144 | 1.200 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.069237 | 1.160 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.069237 | 1.160 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.116588 | 0.933 |
| R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL... | 0.122336 | 0.912 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.122336 | 0.912 |
| R-HSA-8964616 | G beta:gamma signalling through CDC42 | 0.128048 | 0.893 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.128048 | 0.893 |
| R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 0.139360 | 0.856 |
| R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex | 0.150528 | 0.822 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.161551 | 0.792 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.161551 | 0.792 |
| R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | 0.065933 | 1.181 |
| R-HSA-73728 | RNA Polymerase I Promoter Opening | 0.193780 | 0.713 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.078839 | 1.103 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.078839 | 1.103 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.082661 | 1.083 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.084593 | 1.073 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.098489 | 1.007 |
| R-HSA-380287 | Centrosome maturation | 0.102571 | 0.989 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.132336 | 0.878 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.204247 | 0.690 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.136738 | 0.864 |
| R-HSA-1538133 | G0 and Early G1 | 0.219697 | 0.658 |
| R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex | 0.177822 | 0.750 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.123637 | 0.908 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.116588 | 0.933 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 0.069237 | 1.160 |
| R-HSA-69091 | Polymerase switching | 0.099117 | 1.004 |
| R-HSA-69109 | Leading Strand Synthesis | 0.099117 | 1.004 |
| R-HSA-110320 | Translesion Synthesis by POLH | 0.144962 | 0.839 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.193780 | 0.713 |
| R-HSA-5673000 | RAF activation | 0.234849 | 0.629 |
| R-HSA-5696400 | Dual Incision in GG-NER | 0.234849 | 0.629 |
| R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement P... | 0.075290 | 1.123 |
| R-HSA-4419969 | Depolymerization of the Nuclear Lamina | 0.139360 | 0.856 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.183176 | 0.737 |
| R-HSA-9925563 | Developmental Lineage of Pancreatic Ductal Cells | 0.090471 | 1.043 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.229831 | 0.639 |
| R-HSA-9620244 | Long-term potentiation | 0.183176 | 0.737 |
| R-HSA-397795 | G-protein beta:gamma signalling | 0.224780 | 0.648 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.224780 | 0.648 |
| R-HSA-525793 | Myogenesis | 0.188495 | 0.725 |
| R-HSA-916853 | Degradation of GABA | 0.075290 | 1.123 |
| R-HSA-420029 | Tight junction interactions | 0.183176 | 0.737 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.075075 | 1.125 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 0.209430 | 0.679 |
| R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | 0.219697 | 0.658 |
| R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | 0.239835 | 0.620 |
| R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 | 0.239835 | 0.620 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.121485 | 0.915 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.143816 | 0.842 |
| R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 0.188495 | 0.725 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.152208 | 0.818 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.224780 | 0.648 |
| R-HSA-4641258 | Degradation of DVL | 0.249710 | 0.603 |
| R-HSA-5617833 | Cilium Assembly | 0.156586 | 0.805 |
| R-HSA-69186 | Lagging Strand Synthesis | 0.156057 | 0.807 |
| R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) | 0.104978 | 0.979 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.161551 | 0.792 |
| R-HSA-9839394 | TGFBR3 expression | 0.183176 | 0.737 |
| R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 0.244789 | 0.611 |
| R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 0.244789 | 0.611 |
| R-HSA-4641257 | Degradation of AXIN | 0.249710 | 0.603 |
| R-HSA-9762114 | GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | 0.249710 | 0.603 |
| R-HSA-9609690 | HCMV Early Events | 0.165984 | 0.780 |
| R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | 0.102571 | 0.989 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.172989 | 0.762 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.075290 | 1.123 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.177629 | 0.750 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.133722 | 0.874 |
| R-HSA-69190 | DNA strand elongation | 0.219697 | 0.658 |
| R-HSA-9930044 | Nuclear RNA decay | 0.224780 | 0.648 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.096466 | 1.016 |
| R-HSA-180534 | Vpu mediated degradation of CD4 | 0.229831 | 0.639 |
| R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 | 0.234849 | 0.629 |
| R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D | 0.234849 | 0.629 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.121485 | 0.915 |
| R-HSA-9820448 | Developmental Cell Lineages of the Exocrine Pancreas | 0.100335 | 0.999 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.198731 | 0.702 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.067730 | 1.169 |
| R-HSA-69239 | Synthesis of DNA | 0.182288 | 0.739 |
| R-HSA-73886 | Chromosome Maintenance | 0.220120 | 0.657 |
| R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | 0.128048 | 0.893 |
| R-HSA-114608 | Platelet degranulation | 0.236889 | 0.625 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.182326 | 0.739 |
| R-HSA-69275 | G2/M Transition | 0.150418 | 0.823 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.112974 | 0.947 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.153492 | 0.814 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 0.194013 | 0.712 |
| R-HSA-69242 | S Phase | 0.095118 | 1.022 |
| R-HSA-392517 | Rap1 signalling | 0.144962 | 0.839 |
| R-HSA-75109 | Triglyceride biosynthesis | 0.193780 | 0.713 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.076950 | 1.114 |
| R-HSA-73884 | Base Excision Repair | 0.136738 | 0.864 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.194013 | 0.712 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.099117 | 1.004 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.127969 | 0.893 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.205834 | 0.686 |
| R-HSA-1483213 | Synthesis of PE | 0.193780 | 0.713 |
| R-HSA-69205 | G1/S-Specific Transcription | 0.244789 | 0.611 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.096466 | 1.016 |
| R-HSA-194138 | Signaling by VEGF | 0.232089 | 0.634 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.172342 | 0.764 |
| R-HSA-888590 | GABA synthesis, release, reuptake and degradation | 0.209430 | 0.679 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.092457 | 1.034 |
| R-HSA-69306 | DNA Replication | 0.101657 | 0.993 |
| R-HSA-445144 | Signal transduction by L1 | 0.150528 | 0.822 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 0.209430 | 0.679 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.143400 | 0.843 |
| R-HSA-70171 | Glycolysis | 0.163773 | 0.786 |
| R-HSA-4086400 | PCP/CE pathway | 0.108780 | 0.963 |
| R-HSA-69206 | G1/S Transition | 0.232089 | 0.634 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.138335 | 0.859 |
| R-HSA-435354 | Zinc transporters | 0.110802 | 0.955 |
| R-HSA-373755 | Semaphorin interactions | 0.078839 | 1.103 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.209430 | 0.679 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.224780 | 0.648 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.249710 | 0.603 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.168370 | 0.774 |
| R-HSA-9913635 | Strand-asynchronous mitochondrial DNA replication | 0.144962 | 0.839 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.087513 | 1.058 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.102571 | 0.989 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.177155 | 0.752 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.079680 | 1.099 |
| R-HSA-5693538 | Homology Directed Repair | 0.212965 | 0.672 |
| R-HSA-70326 | Glucose metabolism | 0.210585 | 0.677 |
| R-HSA-75205 | Dissolution of Fibrin Clot | 0.087281 | 1.059 |
| R-HSA-182971 | EGFR downregulation | 0.214580 | 0.668 |
| R-HSA-3371556 | Cellular response to heat stress | 0.220120 | 0.657 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.177155 | 0.752 |
| R-HSA-74160 | Gene expression (Transcription) | 0.148231 | 0.829 |
| R-HSA-196757 | Metabolism of folate and pterines | 0.249710 | 0.603 |
| R-HSA-5576891 | Cardiac conduction | 0.248912 | 0.604 |
| R-HSA-1500931 | Cell-Cell communication | 0.069463 | 1.158 |
| R-HSA-211000 | Gene Silencing by RNA | 0.182288 | 0.739 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.161484 | 0.792 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.100335 | 0.999 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.221087 | 0.655 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.209430 | 0.679 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.176950 | 0.752 |
| R-HSA-449147 | Signaling by Interleukins | 0.129696 | 0.887 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.251320 | 0.600 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.253047 | 0.597 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.253728 | 0.596 |
| R-HSA-9609646 | HCMV Infection | 0.258288 | 0.588 |
| R-HSA-9929356 | GSK3B-mediated proteasomal degradation of PD-L1(CD274) | 0.259458 | 0.586 |
| R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 0.259458 | 0.586 |
| R-HSA-69541 | Stabilization of p53 | 0.259458 | 0.586 |
| R-HSA-421270 | Cell-cell junction organization | 0.260039 | 0.585 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.263366 | 0.579 |
| R-HSA-9646399 | Aggrephagy | 0.264285 | 0.578 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.264285 | 0.578 |
| R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 0.264285 | 0.578 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.264285 | 0.578 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.268816 | 0.571 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.269081 | 0.570 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.269081 | 0.570 |
| R-HSA-5362768 | Hh mutants are degraded by ERAD | 0.269081 | 0.570 |
| R-HSA-9929491 | SPOP-mediated proteasomal degradation of PD-L1(CD274) | 0.269081 | 0.570 |
| R-HSA-5676590 | NIK-->noncanonical NF-kB signaling | 0.269081 | 0.570 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.269081 | 0.570 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.273846 | 0.562 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.273846 | 0.562 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.273846 | 0.562 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.273846 | 0.562 |
| R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome | 0.273846 | 0.562 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.273846 | 0.562 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.273846 | 0.562 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.278580 | 0.555 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.280236 | 0.552 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.281162 | 0.551 |
| R-HSA-5387390 | Hh mutants abrogate ligand secretion | 0.283283 | 0.548 |
| R-HSA-69236 | G1 Phase | 0.287956 | 0.541 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.287956 | 0.541 |
| R-HSA-9907900 | Proteasome assembly | 0.287956 | 0.541 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.287956 | 0.541 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.287956 | 0.541 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.289867 | 0.538 |
| R-HSA-774815 | Nucleosome assembly | 0.292599 | 0.534 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.292599 | 0.534 |
| R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 0.292599 | 0.534 |
| R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 0.292599 | 0.534 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.292599 | 0.534 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.292599 | 0.534 |
| R-HSA-9824272 | Somitogenesis | 0.292599 | 0.534 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.297212 | 0.527 |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | 0.297212 | 0.527 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.297212 | 0.527 |
| R-HSA-75153 | Apoptotic execution phase | 0.297212 | 0.527 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.300665 | 0.522 |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | 0.301795 | 0.520 |
| R-HSA-1483191 | Synthesis of PC | 0.301795 | 0.520 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.301795 | 0.520 |
| R-HSA-425410 | Metal ion SLC transporters | 0.306349 | 0.514 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.306685 | 0.513 |
| R-HSA-446728 | Cell junction organization | 0.307779 | 0.512 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.309082 | 0.510 |
| R-HSA-73893 | DNA Damage Bypass | 0.310873 | 0.507 |
| R-HSA-9766229 | Degradation of CDH1 | 0.310873 | 0.507 |
| R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 0.310873 | 0.507 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.310873 | 0.507 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.310873 | 0.507 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.311478 | 0.507 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.315368 | 0.501 |
| R-HSA-9610379 | HCMV Late Events | 0.316264 | 0.500 |
| R-HSA-162587 | HIV Life Cycle | 0.316264 | 0.500 |
| R-HSA-9864848 | Complex IV assembly | 0.319833 | 0.495 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.319833 | 0.495 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | 0.319833 | 0.495 |
| R-HSA-5358346 | Hedgehog ligand biogenesis | 0.319833 | 0.495 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.323430 | 0.490 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.323430 | 0.490 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.324270 | 0.489 |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 0.324270 | 0.489 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.324270 | 0.489 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.324270 | 0.489 |
| R-HSA-9931269 | AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) | 0.324270 | 0.489 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.326073 | 0.487 |
| R-HSA-109581 | Apoptosis | 0.328197 | 0.484 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.328679 | 0.483 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.328679 | 0.483 |
| R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th... | 0.328679 | 0.483 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.328679 | 0.483 |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 0.333058 | 0.477 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.333058 | 0.477 |
| R-HSA-162582 | Signal Transduction | 0.335562 | 0.474 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.337410 | 0.472 |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | 0.337410 | 0.472 |
| R-HSA-9012852 | Signaling by NOTCH3 | 0.337410 | 0.472 |
| R-HSA-5619102 | SLC transporter disorders | 0.340076 | 0.468 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.341733 | 0.466 |
| R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | 0.341733 | 0.466 |
| R-HSA-177929 | Signaling by EGFR | 0.341733 | 0.466 |
| R-HSA-195721 | Signaling by WNT | 0.343407 | 0.464 |
| R-HSA-1483166 | Synthesis of PA | 0.346029 | 0.461 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.346029 | 0.461 |
| R-HSA-72306 | tRNA processing | 0.349534 | 0.457 |
| R-HSA-6782135 | Dual incision in TC-NER | 0.350296 | 0.456 |
| R-HSA-180786 | Extension of Telomeres | 0.354536 | 0.450 |
| R-HSA-8979227 | Triglyceride metabolism | 0.354536 | 0.450 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.356598 | 0.448 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.356598 | 0.448 |
| R-HSA-983189 | Kinesins | 0.358749 | 0.445 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.358749 | 0.445 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.358749 | 0.445 |
| R-HSA-351202 | Metabolism of polyamines | 0.358749 | 0.445 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.362935 | 0.440 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 0.362935 | 0.440 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.367093 | 0.435 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.367093 | 0.435 |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | 0.367093 | 0.435 |
| R-HSA-186797 | Signaling by PDGF | 0.367093 | 0.435 |
| R-HSA-168255 | Influenza Infection | 0.370645 | 0.431 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.371224 | 0.430 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.371224 | 0.430 |
| R-HSA-1234174 | Cellular response to hypoxia | 0.379407 | 0.421 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.379944 | 0.420 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.387485 | 0.412 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.391132 | 0.408 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.391485 | 0.407 |
| R-HSA-1280218 | Adaptive Immune System | 0.394659 | 0.404 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.399406 | 0.399 |
| R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 0.399406 | 0.399 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.403329 | 0.394 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.403329 | 0.394 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.403329 | 0.394 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.403329 | 0.394 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.403329 | 0.394 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.403329 | 0.394 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.407226 | 0.390 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.409758 | 0.387 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.411098 | 0.386 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.411098 | 0.386 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.411098 | 0.386 |
| R-HSA-9013694 | Signaling by NOTCH4 | 0.414945 | 0.382 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.418767 | 0.378 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.419256 | 0.378 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.422564 | 0.374 |
| R-HSA-5689603 | UCH proteinases | 0.422564 | 0.374 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.425528 | 0.371 |
| R-HSA-109582 | Hemostasis | 0.428738 | 0.368 |
| R-HSA-72172 | mRNA Splicing | 0.429994 | 0.367 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.430085 | 0.366 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.430085 | 0.366 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.430085 | 0.366 |
| R-HSA-5619084 | ABC transporter disorders | 0.430085 | 0.366 |
| R-HSA-5357801 | Programmed Cell Death | 0.432220 | 0.364 |
| R-HSA-9925561 | Developmental Lineage of Pancreatic Acinar Cells | 0.433809 | 0.363 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.437509 | 0.359 |
| R-HSA-9856530 | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR... | 0.437509 | 0.359 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.441185 | 0.355 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.448465 | 0.348 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.448465 | 0.348 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.452070 | 0.345 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.455652 | 0.341 |
| R-HSA-9909615 | Regulation of PD-L1(CD274) Post-translational modification | 0.459211 | 0.338 |
| R-HSA-418990 | Adherens junctions interactions | 0.460738 | 0.337 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.466259 | 0.331 |
| R-HSA-70268 | Pyruvate metabolism | 0.466259 | 0.331 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.466259 | 0.331 |
| R-HSA-9663891 | Selective autophagy | 0.469748 | 0.328 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.473216 | 0.325 |
| R-HSA-9824446 | Viral Infection Pathways | 0.475863 | 0.323 |
| R-HSA-202424 | Downstream TCR signaling | 0.476660 | 0.322 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.476660 | 0.322 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.477875 | 0.321 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.480083 | 0.319 |
| R-HSA-391251 | Protein folding | 0.486861 | 0.313 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.490218 | 0.310 |
| R-HSA-913531 | Interferon Signaling | 0.492151 | 0.308 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.493552 | 0.307 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 0.500157 | 0.301 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.503427 | 0.298 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.503427 | 0.298 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.503427 | 0.298 |
| R-HSA-157579 | Telomere Maintenance | 0.506676 | 0.295 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.506676 | 0.295 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.506676 | 0.295 |
| R-HSA-157118 | Signaling by NOTCH | 0.507066 | 0.295 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.513111 | 0.290 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.516297 | 0.287 |
| R-HSA-382556 | ABC-family proteins mediated transport | 0.516297 | 0.287 |
| R-HSA-9020702 | Interleukin-1 signaling | 0.519463 | 0.284 |
| R-HSA-9679506 | SARS-CoV Infections | 0.520279 | 0.284 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.522608 | 0.282 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.531921 | 0.274 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.531921 | 0.274 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.544059 | 0.264 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.544059 | 0.264 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.547045 | 0.262 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.561685 | 0.251 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.562216 | 0.250 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.567409 | 0.246 |
| R-HSA-373760 | L1CAM interactions | 0.573059 | 0.242 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.575856 | 0.240 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.581396 | 0.236 |
| R-HSA-212436 | Generic Transcription Pathway | 0.581681 | 0.235 |
| R-HSA-9759194 | Nuclear events mediated by NFE2L2 | 0.586865 | 0.231 |
| R-HSA-69481 | G2/M Checkpoints | 0.605455 | 0.218 |
| R-HSA-6798695 | Neutrophil degranulation | 0.606088 | 0.217 |
| R-HSA-1483257 | Phospholipid metabolism | 0.611146 | 0.214 |
| R-HSA-9909396 | Circadian clock | 0.620727 | 0.207 |
| R-HSA-112316 | Neuronal System | 0.621542 | 0.207 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.637807 | 0.195 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.637807 | 0.195 |
| R-HSA-199991 | Membrane Trafficking | 0.639035 | 0.194 |
| R-HSA-6807070 | PTEN Regulation | 0.640183 | 0.194 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.643875 | 0.191 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.644891 | 0.191 |
| R-HSA-1632852 | Macroautophagy | 0.644891 | 0.191 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.654124 | 0.184 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.657427 | 0.182 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.657427 | 0.182 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.660892 | 0.180 |
| R-HSA-9758941 | Gastrulation | 0.665331 | 0.177 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.669713 | 0.174 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.671882 | 0.173 |
| R-HSA-73887 | Death Receptor Signaling | 0.676178 | 0.170 |
| R-HSA-9612973 | Autophagy | 0.680419 | 0.167 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.684605 | 0.165 |
| R-HSA-877300 | Interferon gamma signaling | 0.686678 | 0.163 |
| R-HSA-73894 | DNA Repair | 0.711780 | 0.148 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.714315 | 0.146 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.716194 | 0.145 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.718061 | 0.144 |
| R-HSA-422475 | Axon guidance | 0.718110 | 0.144 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.719915 | 0.143 |
| R-HSA-611105 | Respiratory electron transport | 0.725407 | 0.139 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.742954 | 0.129 |
| R-HSA-983712 | Ion channel transport | 0.744646 | 0.128 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.752944 | 0.123 |
| R-HSA-168256 | Immune System | 0.753073 | 0.123 |
| R-HSA-9675108 | Nervous system development | 0.757315 | 0.121 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.762549 | 0.118 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.765668 | 0.116 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.782110 | 0.107 |
| R-HSA-168249 | Innate Immune System | 0.786526 | 0.104 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.786724 | 0.104 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.787800 | 0.104 |
| R-HSA-8951664 | Neddylation | 0.794708 | 0.100 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.794840 | 0.100 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.805300 | 0.094 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.806585 | 0.093 |
| R-HSA-72312 | rRNA processing | 0.809130 | 0.092 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.811643 | 0.091 |
| R-HSA-2262752 | Cellular responses to stress | 0.814669 | 0.089 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.815350 | 0.089 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.820195 | 0.086 |
| R-HSA-4839726 | Chromatin organization | 0.829469 | 0.081 |
| R-HSA-5688426 | Deubiquitination | 0.836122 | 0.078 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.863017 | 0.064 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.874358 | 0.058 |
| R-HSA-5663205 | Infectious disease | 0.880940 | 0.055 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.908129 | 0.042 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.920145 | 0.036 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.920676 | 0.036 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.930602 | 0.031 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.936808 | 0.028 |
| R-HSA-72766 | Translation | 0.949004 | 0.023 |
| R-HSA-1266738 | Developmental Biology | 0.951917 | 0.021 |
| R-HSA-382551 | Transport of small molecules | 0.962363 | 0.017 |
| R-HSA-388396 | GPCR downstream signalling | 0.968305 | 0.014 |
| R-HSA-597592 | Post-translational protein modification | 0.968480 | 0.014 |
| R-HSA-1643685 | Disease | 0.971088 | 0.013 |
| R-HSA-372790 | Signaling by GPCR | 0.980420 | 0.009 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.985758 | 0.006 |
| R-HSA-392499 | Metabolism of proteins | 0.993012 | 0.003 |
| R-HSA-556833 | Metabolism of lipids | 0.999614 | 0.000 |
| R-HSA-1430728 | Metabolism | 0.999980 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
JNK2 |
0.805 | 0.785 | 1 | 0.858 |
JNK3 |
0.794 | 0.765 | 1 | 0.838 |
P38G |
0.794 | 0.768 | 1 | 0.898 |
P38B |
0.792 | 0.726 | 1 | 0.838 |
P38D |
0.788 | 0.748 | 1 | 0.873 |
ERK2 |
0.784 | 0.749 | 1 | 0.806 |
CDK6 |
0.782 | 0.709 | 1 | 0.836 |
P38A |
0.781 | 0.697 | 1 | 0.766 |
CDK1 |
0.780 | 0.733 | 1 | 0.847 |
CDK16 |
0.780 | 0.738 | 1 | 0.881 |
CDK4 |
0.780 | 0.718 | 1 | 0.864 |
ERK1 |
0.779 | 0.725 | 1 | 0.844 |
CDK3 |
0.778 | 0.679 | 1 | 0.883 |
JNK1 |
0.778 | 0.695 | 1 | 0.865 |
CDK5 |
0.777 | 0.710 | 1 | 0.789 |
CDK17 |
0.774 | 0.751 | 1 | 0.892 |
CDK14 |
0.770 | 0.706 | 1 | 0.828 |
CDK2 |
0.765 | 0.610 | 1 | 0.746 |
NLK |
0.765 | 0.675 | 1 | 0.574 |
CDK18 |
0.764 | 0.724 | 1 | 0.861 |
CDK10 |
0.763 | 0.685 | 1 | 0.837 |
CDK13 |
0.762 | 0.726 | 1 | 0.836 |
GAK |
0.759 | -0.001 | 1 | 0.241 |
HIPK1 |
0.759 | 0.570 | 1 | 0.746 |
CDK12 |
0.759 | 0.714 | 1 | 0.856 |
CDK9 |
0.757 | 0.715 | 1 | 0.829 |
TAK1 |
0.753 | -0.081 | 1 | 0.172 |
PRP4 |
0.752 | 0.370 | -3 | 0.609 |
DYRK1B |
0.750 | 0.618 | 1 | 0.813 |
PKR |
0.750 | -0.029 | 1 | 0.204 |
CDK8 |
0.749 | 0.701 | 1 | 0.816 |
MINK |
0.749 | -0.073 | 1 | 0.178 |
VRK2 |
0.748 | 0.003 | 1 | 0.297 |
LRRK2 |
0.747 | -0.028 | 2 | 0.782 |
CDK7 |
0.747 | 0.693 | 1 | 0.814 |
HIPK2 |
0.747 | 0.627 | 1 | 0.834 |
HIPK3 |
0.746 | 0.548 | 1 | 0.718 |
TNIK |
0.746 | -0.042 | 3 | 0.830 |
MEK1 |
0.746 | -0.005 | 2 | 0.819 |
DYRK2 |
0.745 | 0.609 | 1 | 0.760 |
CAMKK1 |
0.745 | -0.026 | -2 | 0.763 |
MAK |
0.745 | 0.380 | -2 | 0.550 |
EEF2K |
0.745 | -0.033 | 3 | 0.822 |
MOK |
0.744 | 0.366 | 1 | 0.633 |
HGK |
0.744 | -0.051 | 3 | 0.827 |
BIKE |
0.743 | -0.040 | 1 | 0.218 |
ERK5 |
0.743 | 0.385 | 1 | 0.488 |
TAO2 |
0.743 | -0.038 | 2 | 0.804 |
MST1 |
0.742 | -0.098 | 1 | 0.187 |
NEK1 |
0.742 | -0.105 | 1 | 0.170 |
BRAF |
0.742 | -0.052 | -4 | 0.755 |
KHS2 |
0.742 | -0.021 | 1 | 0.206 |
ASK1 |
0.742 | -0.127 | 1 | 0.211 |
MST2 |
0.741 | -0.098 | 1 | 0.193 |
MEKK2 |
0.741 | -0.062 | 2 | 0.805 |
CDK19 |
0.741 | 0.692 | 1 | 0.844 |
CAMKK2 |
0.741 | -0.042 | -2 | 0.755 |
MST3 |
0.741 | -0.012 | 2 | 0.797 |
GCK |
0.740 | -0.092 | 1 | 0.202 |
MPSK1 |
0.740 | 0.006 | 1 | 0.245 |
MEK5 |
0.739 | -0.088 | 2 | 0.804 |
KHS1 |
0.739 | -0.068 | 1 | 0.196 |
AAK1 |
0.739 | -0.017 | 1 | 0.215 |
TAO3 |
0.739 | -0.030 | 1 | 0.235 |
OSR1 |
0.739 | -0.042 | 2 | 0.824 |
ERK7 |
0.738 | 0.234 | 2 | 0.519 |
MYO3A |
0.738 | -0.064 | 1 | 0.194 |
ALK4 |
0.738 | 0.009 | -2 | 0.780 |
ICK |
0.737 | 0.265 | -3 | 0.721 |
LKB1 |
0.737 | -0.026 | -3 | 0.754 |
DYRK1A |
0.737 | 0.485 | 1 | 0.731 |
DYRK4 |
0.737 | 0.628 | 1 | 0.848 |
VRK1 |
0.737 | -0.195 | 2 | 0.783 |
HPK1 |
0.737 | -0.072 | 1 | 0.205 |
PBK |
0.736 | -0.035 | 1 | 0.207 |
YSK1 |
0.736 | -0.079 | 2 | 0.796 |
ZAK |
0.736 | -0.060 | 1 | 0.199 |
STLK3 |
0.736 | -0.108 | 1 | 0.188 |
MEK2 |
0.736 | -0.096 | 2 | 0.806 |
MAP3K15 |
0.735 | -0.128 | 1 | 0.208 |
NIK |
0.734 | -0.067 | -3 | 0.771 |
TTK |
0.733 | -0.079 | -2 | 0.696 |
ALPHAK3 |
0.733 | -0.062 | -1 | 0.681 |
PDK1 |
0.733 | -0.101 | 1 | 0.223 |
MYO3B |
0.733 | -0.078 | 2 | 0.791 |
NEK5 |
0.733 | -0.130 | 1 | 0.182 |
MEKK6 |
0.732 | -0.116 | 1 | 0.203 |
NEK4 |
0.732 | -0.107 | 1 | 0.172 |
MEKK3 |
0.732 | -0.072 | 1 | 0.207 |
DLK |
0.732 | -0.111 | 1 | 0.220 |
BMPR2 |
0.732 | -0.155 | -2 | 0.776 |
CDKL1 |
0.732 | 0.101 | -3 | 0.690 |
CLK3 |
0.731 | 0.416 | 1 | 0.544 |
NEK8 |
0.731 | -0.104 | 2 | 0.772 |
NEK11 |
0.730 | -0.124 | 1 | 0.220 |
MEKK1 |
0.729 | -0.137 | 1 | 0.205 |
LOK |
0.728 | -0.050 | -2 | 0.665 |
CLK4 |
0.728 | 0.311 | -3 | 0.657 |
ALK2 |
0.727 | -0.020 | -2 | 0.769 |
YSK4 |
0.727 | -0.130 | 1 | 0.187 |
ANKRD3 |
0.726 | -0.139 | 1 | 0.205 |
DYRK3 |
0.725 | 0.425 | 1 | 0.707 |
PERK |
0.724 | -0.090 | -2 | 0.795 |
PRPK |
0.724 | -0.098 | -1 | 0.756 |
TAO1 |
0.723 | -0.075 | 1 | 0.198 |
PINK1 |
0.723 | 0.181 | 1 | 0.391 |
TGFBR1 |
0.723 | -0.016 | -2 | 0.760 |
HASPIN |
0.722 | 0.007 | -1 | 0.659 |
CLK1 |
0.722 | 0.344 | -3 | 0.631 |
GRK7 |
0.722 | 0.035 | 1 | 0.254 |
BMPR1B |
0.722 | -0.005 | 1 | 0.171 |
DAPK2 |
0.721 | -0.118 | -3 | 0.765 |
CAMLCK |
0.720 | -0.085 | -2 | 0.669 |
MLK2 |
0.720 | -0.110 | 2 | 0.818 |
DMPK1 |
0.720 | -0.011 | -3 | 0.642 |
PASK |
0.719 | -0.065 | -3 | 0.736 |
KIS |
0.719 | 0.656 | 1 | 0.799 |
SLK |
0.718 | -0.050 | -2 | 0.640 |
LATS1 |
0.718 | -0.044 | -3 | 0.700 |
NEK9 |
0.718 | -0.100 | 2 | 0.820 |
MTOR |
0.717 | 0.209 | 1 | 0.379 |
NEK3 |
0.717 | -0.082 | 1 | 0.194 |
MOS |
0.717 | -0.087 | 1 | 0.239 |
HRI |
0.717 | -0.128 | -2 | 0.750 |
CAMK1B |
0.717 | -0.079 | -3 | 0.757 |
ACVR2A |
0.717 | -0.049 | -2 | 0.738 |
ATR |
0.716 | -0.077 | 1 | 0.236 |
SRPK1 |
0.716 | 0.277 | -3 | 0.625 |
DSTYK |
0.716 | -0.014 | 2 | 0.820 |
MLK1 |
0.715 | -0.082 | 2 | 0.804 |
CDKL5 |
0.715 | 0.113 | -3 | 0.681 |
BMPR1A |
0.715 | -0.004 | 1 | 0.159 |
ACVR2B |
0.714 | -0.068 | -2 | 0.750 |
IRAK4 |
0.713 | -0.089 | 1 | 0.160 |
GRK6 |
0.713 | -0.030 | 1 | 0.209 |
PLK1 |
0.713 | -0.088 | -2 | 0.697 |
GSK3A |
0.713 | 0.221 | 4 | 0.595 |
MST4 |
0.713 | 0.011 | 2 | 0.827 |
NEK2 |
0.712 | -0.098 | 2 | 0.789 |
RAF1 |
0.712 | -0.138 | 1 | 0.193 |
COT |
0.711 | -0.013 | 2 | 0.821 |
SRPK3 |
0.711 | 0.192 | -3 | 0.613 |
GRK5 |
0.711 | -0.073 | -3 | 0.801 |
CHAK2 |
0.711 | -0.057 | -1 | 0.787 |
HIPK4 |
0.711 | 0.332 | 1 | 0.553 |
ROCK2 |
0.710 | -0.056 | -3 | 0.661 |
WNK4 |
0.709 | -0.136 | -2 | 0.706 |
MLK4 |
0.708 | -0.059 | 2 | 0.739 |
CLK2 |
0.707 | 0.341 | -3 | 0.612 |
GSK3B |
0.707 | 0.107 | 4 | 0.588 |
MLK3 |
0.707 | -0.040 | 2 | 0.743 |
CAMK2G |
0.707 | -0.066 | 2 | 0.696 |
SMMLCK |
0.706 | -0.107 | -3 | 0.714 |
PKN3 |
0.706 | -0.064 | -3 | 0.705 |
WNK1 |
0.706 | -0.070 | -2 | 0.700 |
NEK7 |
0.706 | -0.058 | -3 | 0.811 |
DAPK3 |
0.705 | -0.098 | -3 | 0.678 |
ULK2 |
0.705 | -0.084 | 2 | 0.764 |
PIM1 |
0.705 | 0.011 | -3 | 0.660 |
PKCD |
0.704 | -0.037 | 2 | 0.772 |
PIM2 |
0.704 | 0.011 | -3 | 0.637 |
RIPK1 |
0.703 | -0.176 | 1 | 0.177 |
DNAPK |
0.703 | -0.044 | 1 | 0.199 |
CHAK1 |
0.701 | -0.112 | 2 | 0.718 |
BUB1 |
0.701 | -0.054 | -5 | 0.670 |
MASTL |
0.700 | -0.206 | -2 | 0.730 |
PDHK4 |
0.700 | -0.192 | 1 | 0.262 |
MRCKA |
0.700 | -0.024 | -3 | 0.635 |
PDHK1 |
0.700 | -0.178 | 1 | 0.242 |
PKN2 |
0.700 | -0.073 | -3 | 0.732 |
NUAK2 |
0.700 | -0.024 | -3 | 0.734 |
TLK2 |
0.700 | -0.147 | 1 | 0.177 |
IRE1 |
0.699 | -0.058 | 1 | 0.179 |
TLK1 |
0.699 | -0.152 | -2 | 0.719 |
GRK2 |
0.699 | -0.059 | -2 | 0.640 |
P70S6KB |
0.699 | -0.020 | -3 | 0.681 |
DRAK1 |
0.699 | -0.116 | 1 | 0.164 |
CRIK |
0.698 | -0.034 | -3 | 0.587 |
ROCK1 |
0.698 | -0.064 | -3 | 0.633 |
GRK1 |
0.698 | 0.015 | -2 | 0.754 |
SRPK2 |
0.698 | 0.226 | -3 | 0.558 |
HUNK |
0.698 | -0.118 | 2 | 0.769 |
PIM3 |
0.697 | -0.040 | -3 | 0.696 |
DCAMKL1 |
0.697 | -0.081 | -3 | 0.648 |
TSSK2 |
0.697 | -0.121 | -5 | 0.721 |
NEK6 |
0.696 | -0.040 | -2 | 0.724 |
MRCKB |
0.696 | -0.040 | -3 | 0.627 |
CDC7 |
0.696 | -0.091 | 1 | 0.192 |
AMPKA1 |
0.695 | -0.102 | -3 | 0.734 |
DAPK1 |
0.695 | -0.094 | -3 | 0.675 |
TGFBR2 |
0.695 | -0.067 | -2 | 0.720 |
ULK1 |
0.694 | -0.067 | -3 | 0.770 |
DCAMKL2 |
0.694 | -0.083 | -3 | 0.683 |
STK33 |
0.694 | -0.074 | 2 | 0.558 |
RIPK3 |
0.693 | -0.156 | 3 | 0.627 |
CHK1 |
0.693 | -0.117 | -3 | 0.677 |
TBK1 |
0.693 | -0.151 | 1 | 0.176 |
SKMLCK |
0.693 | -0.150 | -2 | 0.648 |
SMG1 |
0.692 | -0.087 | 1 | 0.213 |
WNK3 |
0.691 | -0.179 | 1 | 0.189 |
AKT2 |
0.691 | -0.017 | -3 | 0.584 |
PLK3 |
0.691 | -0.114 | 2 | 0.657 |
RIPK2 |
0.691 | -0.171 | 1 | 0.177 |
IRE2 |
0.690 | -0.087 | 2 | 0.727 |
IRAK1 |
0.690 | -0.182 | -1 | 0.703 |
TTBK2 |
0.690 | -0.135 | 2 | 0.670 |
PKCI |
0.689 | -0.034 | 2 | 0.740 |
PKCH |
0.689 | -0.071 | 2 | 0.726 |
IKKE |
0.688 | -0.145 | 1 | 0.175 |
MARK4 |
0.688 | -0.099 | 4 | 0.777 |
SGK3 |
0.688 | -0.062 | -3 | 0.643 |
PKCZ |
0.687 | -0.086 | 2 | 0.763 |
PKCA |
0.686 | -0.055 | 2 | 0.728 |
IKKB |
0.686 | -0.101 | -2 | 0.735 |
NIM1 |
0.686 | -0.055 | 3 | 0.700 |
MELK |
0.686 | -0.096 | -3 | 0.684 |
RSK2 |
0.686 | -0.022 | -3 | 0.645 |
PKCB |
0.686 | -0.045 | 2 | 0.746 |
ATM |
0.686 | -0.093 | 1 | 0.193 |
SGK1 |
0.686 | -0.011 | -3 | 0.498 |
NDR1 |
0.685 | -0.031 | -3 | 0.698 |
PKCE |
0.684 | -0.027 | 2 | 0.708 |
AMPKA2 |
0.684 | -0.090 | -3 | 0.697 |
QIK |
0.684 | -0.102 | -3 | 0.754 |
TSSK1 |
0.684 | -0.123 | -3 | 0.741 |
AKT1 |
0.683 | -0.039 | -3 | 0.596 |
P90RSK |
0.682 | -0.032 | -3 | 0.642 |
CAMK2D |
0.682 | -0.140 | -3 | 0.735 |
PLK4 |
0.682 | -0.112 | 2 | 0.592 |
IKKA |
0.682 | -0.052 | -2 | 0.730 |
CK1D |
0.681 | 0.063 | -3 | 0.618 |
GCN2 |
0.681 | -0.130 | 2 | 0.766 |
PAK2 |
0.680 | -0.118 | -2 | 0.578 |
GRK4 |
0.680 | -0.109 | -2 | 0.736 |
PKCG |
0.679 | -0.059 | 2 | 0.720 |
PAK1 |
0.679 | -0.092 | -2 | 0.576 |
PKCT |
0.678 | -0.077 | 2 | 0.740 |
CHK2 |
0.678 | -0.077 | -3 | 0.529 |
MYLK4 |
0.678 | -0.098 | -2 | 0.567 |
MAPKAPK3 |
0.677 | -0.109 | -3 | 0.645 |
CAMK4 |
0.677 | -0.158 | -3 | 0.718 |
SBK |
0.677 | 0.041 | -3 | 0.464 |
PAK3 |
0.677 | -0.111 | -2 | 0.589 |
SSTK |
0.676 | -0.092 | 4 | 0.731 |
P70S6K |
0.675 | -0.042 | -3 | 0.609 |
PDHK3_TYR |
0.674 | 0.100 | 4 | 0.867 |
GRK3 |
0.674 | -0.054 | -2 | 0.605 |
RSK4 |
0.674 | -0.016 | -3 | 0.608 |
MARK2 |
0.673 | -0.092 | 4 | 0.670 |
CAMK1G |
0.673 | -0.095 | -3 | 0.663 |
PRKD3 |
0.673 | -0.072 | -3 | 0.629 |
PLK2 |
0.673 | -0.089 | -3 | 0.663 |
CK1A2 |
0.673 | 0.044 | -3 | 0.618 |
AURB |
0.672 | -0.069 | -2 | 0.436 |
TTBK1 |
0.672 | -0.112 | 2 | 0.570 |
BCKDK |
0.671 | -0.143 | -1 | 0.740 |
MARK1 |
0.671 | -0.107 | 4 | 0.732 |
CAMK2B |
0.670 | -0.099 | 2 | 0.677 |
PKACG |
0.670 | -0.074 | -2 | 0.530 |
CAMK1D |
0.669 | -0.101 | -3 | 0.566 |
RSK3 |
0.669 | -0.055 | -3 | 0.630 |
QSK |
0.669 | -0.094 | 4 | 0.749 |
PHKG1 |
0.669 | -0.093 | -3 | 0.701 |
PKG2 |
0.668 | -0.069 | -2 | 0.452 |
CK1E |
0.668 | 0.043 | -3 | 0.649 |
MARK3 |
0.668 | -0.083 | 4 | 0.713 |
MNK1 |
0.667 | -0.079 | -2 | 0.591 |
LATS2 |
0.667 | -0.066 | -5 | 0.754 |
MNK2 |
0.667 | -0.091 | -2 | 0.572 |
TESK1_TYR |
0.667 | 0.005 | 3 | 0.808 |
CAMK2A |
0.666 | -0.085 | 2 | 0.679 |
PAK6 |
0.666 | -0.035 | -2 | 0.542 |
PINK1_TYR |
0.666 | -0.052 | 1 | 0.262 |
NUAK1 |
0.665 | -0.081 | -3 | 0.668 |
PDHK4_TYR |
0.665 | 0.032 | 2 | 0.769 |
PKN1 |
0.665 | -0.073 | -3 | 0.629 |
CK2A2 |
0.665 | -0.049 | 1 | 0.143 |
NDR2 |
0.665 | -0.039 | -3 | 0.697 |
PKMYT1_TYR |
0.664 | 0.050 | 3 | 0.760 |
MSK2 |
0.664 | -0.089 | -3 | 0.626 |
AKT3 |
0.664 | -0.026 | -3 | 0.511 |
LIMK2_TYR |
0.664 | 0.053 | -3 | 0.775 |
MAPKAPK2 |
0.664 | -0.069 | -3 | 0.588 |
BMPR2_TYR |
0.663 | 0.009 | -1 | 0.789 |
YANK3 |
0.663 | -0.042 | 2 | 0.322 |
PRKD1 |
0.662 | -0.110 | -3 | 0.683 |
MAP2K6_TYR |
0.661 | -0.007 | -1 | 0.785 |
CK2A1 |
0.661 | -0.040 | 1 | 0.136 |
SIK |
0.661 | -0.086 | -3 | 0.655 |
MAP2K4_TYR |
0.661 | -0.051 | -1 | 0.778 |
MAP2K7_TYR |
0.661 | -0.098 | 2 | 0.772 |
MSK1 |
0.661 | -0.087 | -3 | 0.627 |
YANK2 |
0.660 | -0.046 | 2 | 0.349 |
AURC |
0.660 | -0.045 | -2 | 0.433 |
PRKD2 |
0.659 | -0.074 | -3 | 0.632 |
PHKG2 |
0.658 | -0.079 | -3 | 0.692 |
PKACB |
0.658 | -0.044 | -2 | 0.440 |
PDHK1_TYR |
0.657 | -0.082 | -1 | 0.802 |
CAMK1A |
0.656 | -0.099 | -3 | 0.532 |
AURA |
0.655 | -0.092 | -2 | 0.411 |
MAPKAPK5 |
0.655 | -0.117 | -3 | 0.619 |
LIMK1_TYR |
0.654 | -0.055 | 2 | 0.793 |
FAM20C |
0.654 | -0.000 | 2 | 0.542 |
SNRK |
0.653 | -0.192 | 2 | 0.611 |
TYK2 |
0.652 | -0.182 | 1 | 0.217 |
NEK10_TYR |
0.652 | -0.083 | 1 | 0.199 |
MST1R |
0.652 | -0.120 | 3 | 0.740 |
EPHA6 |
0.652 | -0.096 | -1 | 0.786 |
RET |
0.651 | -0.161 | 1 | 0.232 |
JAK2 |
0.650 | -0.139 | 1 | 0.236 |
CSF1R |
0.649 | -0.108 | 3 | 0.717 |
BRSK2 |
0.648 | -0.138 | -3 | 0.699 |
PAK5 |
0.646 | -0.081 | -2 | 0.465 |
ROS1 |
0.646 | -0.154 | 3 | 0.724 |
TXK |
0.646 | -0.070 | 1 | 0.174 |
TNNI3K_TYR |
0.646 | -0.063 | 1 | 0.233 |
PKACA |
0.646 | -0.064 | -2 | 0.395 |
TYRO3 |
0.645 | -0.166 | 3 | 0.755 |
FGFR2 |
0.644 | -0.060 | 3 | 0.729 |
EPHB4 |
0.644 | -0.145 | -1 | 0.764 |
JAK3 |
0.644 | -0.140 | 1 | 0.223 |
TEK |
0.644 | -0.020 | 3 | 0.703 |
YES1 |
0.643 | -0.092 | -1 | 0.786 |
FLT3 |
0.643 | -0.130 | 3 | 0.752 |
FGFR1 |
0.643 | -0.056 | 3 | 0.713 |
ABL2 |
0.643 | -0.122 | -1 | 0.763 |
BRSK1 |
0.642 | -0.123 | -3 | 0.663 |
DDR1 |
0.642 | -0.154 | 4 | 0.770 |
ABL1 |
0.641 | -0.110 | -1 | 0.761 |
PRKX |
0.641 | -0.020 | -3 | 0.557 |
KIT |
0.640 | -0.120 | 3 | 0.726 |
WEE1_TYR |
0.640 | -0.074 | -1 | 0.665 |
JAK1 |
0.640 | -0.120 | 1 | 0.203 |
INSRR |
0.640 | -0.127 | 3 | 0.698 |
HCK |
0.640 | -0.129 | -1 | 0.769 |
TNK2 |
0.639 | -0.122 | 3 | 0.696 |
EPHB1 |
0.639 | -0.146 | 1 | 0.189 |
PDGFRB |
0.639 | -0.188 | 3 | 0.749 |
EPHA4 |
0.639 | -0.102 | 2 | 0.641 |
FGR |
0.638 | -0.183 | 1 | 0.194 |
KDR |
0.638 | -0.106 | 3 | 0.682 |
CK1G1 |
0.638 | 0.011 | -3 | 0.612 |
TNK1 |
0.637 | -0.119 | 3 | 0.712 |
ITK |
0.637 | -0.141 | -1 | 0.750 |
TEC |
0.637 | -0.086 | -1 | 0.724 |
BLK |
0.637 | -0.087 | -1 | 0.788 |
SRMS |
0.637 | -0.163 | 1 | 0.185 |
CK1G3 |
0.637 | 0.015 | -3 | 0.494 |
LCK |
0.637 | -0.110 | -1 | 0.767 |
ERBB2 |
0.636 | -0.126 | 1 | 0.223 |
PDGFRA |
0.635 | -0.190 | 3 | 0.753 |
FER |
0.635 | -0.201 | 1 | 0.202 |
PAK4 |
0.635 | -0.076 | -2 | 0.457 |
EPHB2 |
0.635 | -0.141 | -1 | 0.749 |
EPHB3 |
0.635 | -0.157 | -1 | 0.759 |
MET |
0.635 | -0.115 | 3 | 0.719 |
BTK |
0.634 | -0.160 | -1 | 0.724 |
FRK |
0.634 | -0.111 | -1 | 0.795 |
FGFR3 |
0.634 | -0.070 | 3 | 0.700 |
BMX |
0.633 | -0.111 | -1 | 0.678 |
AXL |
0.633 | -0.170 | 3 | 0.705 |
EGFR |
0.633 | -0.086 | 1 | 0.213 |
FLT1 |
0.631 | -0.133 | -1 | 0.749 |
FYN |
0.630 | -0.084 | -1 | 0.751 |
EPHA7 |
0.630 | -0.126 | 2 | 0.661 |
MUSK |
0.630 | -0.100 | 1 | 0.199 |
MERTK |
0.628 | -0.169 | 3 | 0.699 |
FLT4 |
0.627 | -0.151 | 3 | 0.660 |
EPHA3 |
0.627 | -0.138 | 2 | 0.620 |
ALK |
0.627 | -0.159 | 3 | 0.689 |
MATK |
0.627 | -0.099 | -1 | 0.692 |
NTRK2 |
0.627 | -0.189 | 3 | 0.686 |
EPHA8 |
0.625 | -0.103 | -1 | 0.762 |
PTK2B |
0.625 | -0.090 | -1 | 0.740 |
LTK |
0.624 | -0.167 | 3 | 0.684 |
SRC |
0.624 | -0.103 | -1 | 0.760 |
PKG1 |
0.623 | -0.102 | -2 | 0.384 |
LYN |
0.623 | -0.136 | 3 | 0.637 |
EPHA1 |
0.623 | -0.166 | 3 | 0.712 |
INSR |
0.623 | -0.173 | 3 | 0.661 |
PTK6 |
0.623 | -0.205 | -1 | 0.670 |
SYK |
0.623 | -0.070 | -1 | 0.687 |
ERBB4 |
0.622 | -0.064 | 1 | 0.210 |
DDR2 |
0.622 | -0.097 | 3 | 0.688 |
NTRK1 |
0.622 | -0.226 | -1 | 0.729 |
FGFR4 |
0.622 | -0.101 | -1 | 0.684 |
NTRK3 |
0.621 | -0.174 | -1 | 0.677 |
EPHA5 |
0.621 | -0.140 | 2 | 0.630 |
PTK2 |
0.621 | -0.067 | -1 | 0.717 |
CSK |
0.619 | -0.148 | 2 | 0.666 |
CK1G2 |
0.614 | 0.000 | -3 | 0.559 |
EPHA2 |
0.611 | -0.139 | -1 | 0.707 |
CK1A |
0.609 | 0.017 | -3 | 0.536 |
ZAP70 |
0.609 | -0.054 | -1 | 0.621 |
IGF1R |
0.607 | -0.158 | 3 | 0.610 |
FES |
0.602 | -0.121 | -1 | 0.655 |