Motif 1041 (n=57)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A1B0GVI7 | None | Y530 | ochoa | Aryl hydrocarbon receptor | None |
| A6NKT7 | RGPD3 | Y1028 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NKT7 | RGPD3 | T1325 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NMZ7 | COL6A6 | Y493 | ochoa | Collagen alpha-6(VI) chain | Collagen VI acts as a cell-binding protein. {ECO:0000250}. |
| O00151 | PDLIM1 | Y197 | ochoa | PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36) | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). {ECO:0000250|UniProtKB:P52944, ECO:0000269|PubMed:10861853}. |
| O00206 | TLR4 | Y680 | psp | Toll-like receptor 4 (hToll) (CD antigen CD284) | Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways (PubMed:10835634, PubMed:15809303, PubMed:16622205, PubMed:17292937, PubMed:17478729, PubMed:20037584, PubMed:20711192, PubMed:23880187, PubMed:27022195, PubMed:29038465, PubMed:17803912). At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+) (PubMed:20711192). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:10835634, PubMed:21393102, PubMed:27022195, PubMed:36945827, PubMed:9237759). Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production (PubMed:14517278). In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade (PubMed:32894580). In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86 (PubMed:23880187). Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway (PubMed:23880187). In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner (PubMed:15265881, PubMed:23880187). Required for the migration-promoting effects of ZG16B/PAUF on pancreatic cancer cells. {ECO:0000269|PubMed:10835634, ECO:0000269|PubMed:14517278, ECO:0000269|PubMed:15265881, ECO:0000269|PubMed:15809303, ECO:0000269|PubMed:16622205, ECO:0000269|PubMed:17292937, ECO:0000269|PubMed:17478729, ECO:0000269|PubMed:17803912, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:20711192, ECO:0000269|PubMed:23880187, ECO:0000269|PubMed:27022195, ECO:0000269|PubMed:29038465, ECO:0000269|PubMed:36945827, ECO:0000269|PubMed:9237759}. |
| O00410 | IPO5 | Y837 | ochoa | Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}. |
| O14715 | RGPD8 | Y1027 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O43707 | ACTN4 | S121 | ochoa | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:22689882, ECO:0000305|PubMed:9508771}. |
| O75563 | SKAP2 | Y197 | ochoa | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains) | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:9837776}. |
| P00533 | EGFR | Y978 | psp | Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:12297049, PubMed:15611079, PubMed:17909029, PubMed:20837704, PubMed:27153536, PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:35538033, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}. |
| P09327 | VIL1 | Y461 | psp | Villin-1 | Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. {ECO:0000269|PubMed:11500485, ECO:0000269|PubMed:14594952, ECO:0000269|PubMed:15084600, ECO:0000269|PubMed:15272027, ECO:0000269|PubMed:15342783, ECO:0000269|PubMed:16921170, ECO:0000269|PubMed:17182858, ECO:0000269|PubMed:17229814, ECO:0000269|PubMed:17606613, ECO:0000269|PubMed:18054784, ECO:0000269|PubMed:18198174, ECO:0000269|PubMed:19808673, ECO:0000269|PubMed:3087992}. |
| P0DJD0 | RGPD1 | T1309 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T1317 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10451 | SPP1 | Y225 | psp | Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin) | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250|UniProtKB:P10923}. |
| P12814 | ACTN1 | S102 | ochoa | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882). {ECO:0000269|PubMed:22689882}. |
| P13796 | LCP1 | Y299 | ochoa | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}. |
| P31948 | STIP1 | S460 | ochoa | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) | Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity). {ECO:0000250|UniProtKB:O35814, ECO:0000303|PubMed:27353360}. |
| P35609 | ACTN2 | S109 | ochoa | Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| P35869 | AHR | Y540 | ochoa | Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) | Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:23275542, PubMed:30373764, PubMed:32818467, PubMed:7961644). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:23275542, PubMed:30373764, PubMed:7961644). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388). Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644, PubMed:33193710). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:34521881, PubMed:7961644). Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143). Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32818467, PubMed:32866000). Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:28602820, ECO:0000269|PubMed:30373764, ECO:0000269|PubMed:32818467, ECO:0000269|PubMed:32866000, ECO:0000269|PubMed:33193710, ECO:0000269|PubMed:34521881, ECO:0000269|PubMed:7961644, ECO:0000303|PubMed:12213388, ECO:0000303|PubMed:18076143}. |
| P49792 | RANBP2 | Y2003 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | T2300 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P62993 | GRB2 | Y37 | psp | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11726515, PubMed:37626338). Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis (PubMed:35831301, PubMed:37626338, PubMed:38182563). Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702). Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2 (PubMed:9489702). In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation (PubMed:12171928, PubMed:25870599). Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232, PubMed:29523808). Plays a role in switching between autophagy and programmed necrosis upstream of EGFR by interacting with components of necrosomes including RIPK1 and with autophagy regulators SQSTM1 and BECN1 (PubMed:35831301, PubMed:38182563). Regulates miRNA biogenesis by forming a functional ternary complex with AGO2 and DICER1 (PubMed:37328606). Functions in the replication stress response by protecting DNA at stalled replication forks from MRE11-mediated degradation. Mechanistically, inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks (PubMed:38459011). Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process (PubMed:34348893). {ECO:0000269|PubMed:11726515, ECO:0000269|PubMed:12171928, ECO:0000269|PubMed:1322798, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:25413232, ECO:0000269|PubMed:25870599, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:34348893, ECO:0000269|PubMed:35831301, ECO:0000269|PubMed:36864087, ECO:0000269|PubMed:37328606, ECO:0000269|PubMed:37626338, ECO:0000269|PubMed:38182563, ECO:0000269|PubMed:38459011, ECO:0000269|PubMed:9489702}.; FUNCTION: [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Mechanistically, inhibits RAS-ERK signaling and downstream cell proliferation by competing with GRB2 for SOS1 binding and thus by regulating SOS1 membrane recruitment (PubMed:36171279). {ECO:0000269|PubMed:36171279, ECO:0000269|PubMed:8178156}. |
| P63096 | GNAI1 | Y154 | psp | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38552625, PubMed:8774883, PubMed:38918398). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). {ECO:0000250|UniProtKB:P10824, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:34239069, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:38918398, ECO:0000269|PubMed:8119955, ECO:0000269|PubMed:8774883}. |
| P67809 | YBX1 | Y99 | psp | Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969, PubMed:8188694). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:18809583, PubMed:8188694). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673). {ECO:0000250|UniProtKB:P62960, ECO:0000250|UniProtKB:Q28618, ECO:0000269|PubMed:10817758, ECO:0000269|PubMed:11698476, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:14718551, ECO:0000269|PubMed:18809583, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19483673, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:27559612, ECO:0000269|PubMed:28341602, ECO:0000269|PubMed:29073095, ECO:0000269|PubMed:29712925, ECO:0000269|PubMed:31358969, ECO:0000269|PubMed:8188694}. |
| P78314 | SH3BP2 | Y174 | psp | SH3 domain-binding protein 2 (3BP-2) | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. |
| Q08043 | ACTN3 | S116 | ochoa | Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein) | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Q13283 | G3BP1 | Y133 | psp | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | Protein involved in various processes, such as stress granule formation and innate immunity (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:30510222, PubMed:30804210). Plays an essential role in stress granule formation (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:35977029, PubMed:36183834, PubMed:36279435, PubMed:36692217, PubMed:37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:12642610, PubMed:20180778, PubMed:23279204, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:36279435, PubMed:37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:34739333, PubMed:36279435, PubMed:36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PubMed:30510222, PubMed:30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PubMed:30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PubMed:34779554). Also enhances RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PubMed:30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:12642610, ECO:0000269|PubMed:20180778, ECO:0000269|PubMed:23279204, ECO:0000269|PubMed:27022092, ECO:0000269|PubMed:30510222, ECO:0000269|PubMed:30804210, ECO:0000269|PubMed:32302570, ECO:0000269|PubMed:32302571, ECO:0000269|PubMed:32302572, ECO:0000269|PubMed:34739333, ECO:0000269|PubMed:34779554, ECO:0000269|PubMed:35977029, ECO:0000269|PubMed:36183834, ECO:0000269|PubMed:36279435, ECO:0000269|PubMed:36692217, ECO:0000269|PubMed:37379838, ECO:0000269|PubMed:9889278}. |
| Q15303 | ERBB4 | Y984 | psp | Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}. |
| Q7Z3J3 | RGPD4 | Y1028 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3J3 | RGPD4 | T1325 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q8IVH8 | MAP4K3 | S295 | ochoa | Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}. |
| Q96SD1 | DCLRE1C | Y391 | ochoa | Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein) | Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:11955432, PubMed:15071507, PubMed:15574326, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}. |
| Q99666 | RGPD5 | Y1027 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9UDY2 | TJP2 | Y932 | ochoa | Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2) | Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity). {ECO:0000250|UniProtKB:Q9Z0U1}. |
| Q9Y608 | LRRFIP2 | Y398 | ochoa | Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}. |
| O43852 | CALU | T89 | Sugiyama | Calumenin (Crocalbin) (IEF SSP 9302) | Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}. |
| P46777 | RPL5 | Y219 | Sugiyama | Large ribosomal subunit protein uL18 (60S ribosomal protein L5) | Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). {ECO:0000269|PubMed:12962325, ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:24120868}. |
| Q15067 | ACOX1 | Y239 | Sugiyama | Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain] | Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382, PubMed:7876265). Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) (PubMed:17458872, PubMed:17603022, PubMed:7876265). {ECO:0000269|PubMed:15060085, ECO:0000269|PubMed:17458872, ECO:0000269|PubMed:17603022, ECO:0000269|PubMed:32169171, ECO:0000269|PubMed:33234382, ECO:0000269|PubMed:7876265}.; FUNCTION: [Isoform 1]: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. {ECO:0000269|PubMed:17603022}.; FUNCTION: [Isoform 2]: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. {ECO:0000269|PubMed:17603022}. |
| Q99538 | LGMN | Y53 | Sugiyama | Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (AEP) (Protease, cysteine 1) | Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (PubMed:9872320). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). {ECO:0000250|UniProtKB:O89017, ECO:0000269|PubMed:23776206, ECO:0000269|PubMed:9872320}. |
| P07602 | PSAP | Y113 | Sugiyama | Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] | Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; FUNCTION: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; FUNCTION: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; FUNCTION: [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {ECO:0000250|UniProtKB:Q61207, ECO:0000269|PubMed:10383054}.; FUNCTION: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. |
| P63010 | AP2B1 | Y526 | Sugiyama | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. {ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:14985334, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}. |
| Q10567 | AP1B1 | Y526 | Sugiyama | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:31630791}. |
| Q13573 | SNW1 | Y459 | Sugiyama | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}. |
| P25205 | MCM3 | Y705 | Sugiyama | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable). {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000305|PubMed:35585232}. |
| Q9UI12 | ATP6V1H | Y355 | Sugiyama | V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (PubMed:12032142). {ECO:0000250|UniProtKB:O46563, ECO:0000250|UniProtKB:P41807, ECO:0000269|PubMed:12032142, ECO:0000269|PubMed:33065002}. |
| P23258 | TUBG1 | Y53 | Sugiyama | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685, PubMed:38609661, PubMed:39321809). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809). {ECO:0000269|PubMed:38305685, ECO:0000269|PubMed:38609661, ECO:0000269|PubMed:39321809}. |
| Q9NRH3 | TUBG2 | Y53 | Sugiyama | Tubulin gamma-2 chain (Gamma-2-tubulin) | Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685). {ECO:0000269|PubMed:38305685}. |
| Q9NTK5 | OLA1 | Y375 | Sugiyama | Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9) | Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. {ECO:0000255|HAMAP-Rule:MF_03167}. |
| O00429 | DNM1L | Y691 | Sugiyama | Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) | Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531, PubMed:33850055). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23283981, PubMed:23921378, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:26992161, PubMed:27145208, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:20688057, PubMed:23792689, PubMed:9570752). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27145933, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| P35613 | BSG | Y256 | Sugiyama | Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) | [Isoform 1]: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:21620857, ECO:0000269|PubMed:25957687}.; FUNCTION: [Isoform 1]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7 and Dd2. {ECO:0000269|PubMed:22080952}.; FUNCTION: [Isoform 2]: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed:11688976, PubMed:11943775). Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:17127621, PubMed:21778275, PubMed:28666119). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed:25825981). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed:19837976). Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed:11992541, PubMed:12553375, PubMed:15833850). {ECO:0000269|PubMed:11688976, ECO:0000269|PubMed:11943775, ECO:0000269|PubMed:11992541, ECO:0000269|PubMed:12553375, ECO:0000269|PubMed:15833850, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19837976, ECO:0000269|PubMed:21778275, ECO:0000269|PubMed:25825981, ECO:0000269|PubMed:28666119}.; FUNCTION: [Isoform 2]: (Microbial infection) Erythrocyte receptor for P.falciparum RH5 which is essential for erythrocyte invasion by the merozoite stage of P.falciparum isolates 3D7, Dd2, 7G8 and HB3 (PubMed:22080952, PubMed:26195724). Binding of P.falciparum RH5 results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866). {ECO:0000269|PubMed:22080952, ECO:0000269|PubMed:26195724, ECO:0000269|PubMed:28409866}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate human SARS coronavirus (SARS-CoV-1) infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:15688292}.; FUNCTION: [Isoform 2]: (Microbial infection) Can facilitate HIV-1 infection via its interaction with virus-associated PPIA/CYPA. {ECO:0000269|PubMed:11353871}.; FUNCTION: [Isoform 2]: (Microbial infection) First described as a receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is not required for SARS-CoV-2 infection. {ECO:0000269|PubMed:33432067, ECO:0000303|PubMed:32307653}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:20147391}.; FUNCTION: [Isoform 2]: (Microbial infection) Promotes entry of pentamer-expressing human cytomegalovirus (HCMV) into epithelial and endothelial cells. {ECO:0000269|PubMed:29739904}. |
| P08865 | RPSA | Y202 | Sugiyama | Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:6300843}.; FUNCTION: (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; FUNCTION: (Microbial infection) Acts as a receptor for the Dengue virus. {ECO:0000269|PubMed:15507651}.; FUNCTION: (Microbial infection) Acts as a receptor for the Sindbis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. {ECO:0000269|PubMed:1385835}.; FUNCTION: (Microbial infection) Acts as a receptor for the pathogenic prion protein. {ECO:0000269|PubMed:11689427, ECO:0000269|PubMed:9396609}.; FUNCTION: (Microbial infection) Acts as a receptor for bacteria. {ECO:0000269|PubMed:15516338}. |
| P08754 | GNAI3 | Y154 | Sugiyama | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:19478087, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (PubMed:37137991). {ECO:0000250|UniProtKB:P08753, ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:2535845, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:8774883}. |
| Q9BQG0 | MYBBP1A | Y355 | Sugiyama | Myb-binding protein 1A | May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309). {ECO:0000250|UniProtKB:Q7TPV4, ECO:0000269|PubMed:29065309}. |
| Q96N67 | DOCK7 | Y169 | Sugiyama | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| P48643 | CCT5 | T69 | Sugiyama | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P13667 | PDIA4 | Y595 | Sugiyama | Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) | None |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-1963640 | GRB2 events in ERBB2 signaling | 4.907062e-08 | 7.309 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 2.830057e-07 | 6.548 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 6.011899e-07 | 6.221 |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | 6.897325e-07 | 6.161 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 6.897325e-07 | 6.161 |
| R-HSA-8847993 | ERBB2 Activates PTK6 Signaling | 1.511479e-06 | 5.821 |
| R-HSA-391160 | Signal regulatory protein family interactions | 1.511479e-06 | 5.821 |
| R-HSA-6785631 | ERBB2 Regulates Cell Motility | 1.870087e-06 | 5.728 |
| R-HSA-1236394 | Signaling by ERBB4 | 2.042811e-06 | 5.690 |
| R-HSA-1250347 | SHC1 events in ERBB4 signaling | 2.772015e-06 | 5.557 |
| R-HSA-1963642 | PI3K events in ERBB2 signaling | 3.327705e-06 | 5.478 |
| R-HSA-373753 | Nephrin family interactions | 5.493157e-06 | 5.260 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 6.794563e-06 | 5.168 |
| R-HSA-9620244 | Long-term potentiation | 1.272706e-05 | 4.895 |
| R-HSA-1227986 | Signaling by ERBB2 | 1.484731e-05 | 4.828 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 1.835087e-05 | 4.736 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 2.350490e-05 | 4.629 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 2.276031e-05 | 4.643 |
| R-HSA-114608 | Platelet degranulation | 4.464406e-05 | 4.350 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 5.814440e-05 | 4.235 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 6.372096e-05 | 4.196 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 8.368029e-05 | 4.077 |
| R-HSA-5683826 | Surfactant metabolism | 9.388625e-05 | 4.027 |
| R-HSA-1500931 | Cell-Cell communication | 1.310153e-04 | 3.883 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 1.417217e-04 | 3.849 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 3.174198e-04 | 3.498 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 3.061300e-04 | 3.514 |
| R-HSA-8848021 | Signaling by PTK6 | 3.061300e-04 | 3.514 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 6.164123e-04 | 3.210 |
| R-HSA-5688890 | Defective CSF2RA causes SMDP4 | 6.164123e-04 | 3.210 |
| R-HSA-5688849 | Defective CSF2RB causes SMDP5 | 6.164123e-04 | 3.210 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 8.632607e-04 | 3.064 |
| R-HSA-112315 | Transmission across Chemical Synapses | 8.737642e-04 | 3.059 |
| R-HSA-109582 | Hemostasis | 8.709554e-04 | 3.060 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 9.575937e-04 | 3.019 |
| R-HSA-8949275 | RUNX3 Regulates Immune Response and Cell Migration | 9.575937e-04 | 3.019 |
| R-HSA-438064 | Post NMDA receptor activation events | 9.409547e-04 | 3.026 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 1.261806e-03 | 2.899 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 1.604375e-03 | 2.795 |
| R-HSA-2179392 | EGFR Transactivation by Gastrin | 1.604375e-03 | 2.795 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 1.706501e-03 | 2.768 |
| R-HSA-1250342 | PI3K events in ERBB4 signaling | 2.123713e-03 | 2.673 |
| R-HSA-179812 | GRB2 events in EGFR signaling | 2.409356e-03 | 2.618 |
| R-HSA-5687613 | Diseases associated with surfactant metabolism | 2.409356e-03 | 2.618 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 2.645651e-03 | 2.577 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 2.707754e-03 | 2.567 |
| R-HSA-9012852 | Signaling by NOTCH3 | 2.919969e-03 | 2.535 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 2.953407e-03 | 2.530 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 2.982260e-03 | 2.525 |
| R-HSA-170670 | Adenylate cyclase inhibitory pathway | 3.368320e-03 | 2.473 |
| R-HSA-180336 | SHC1 events in EGFR signaling | 3.368320e-03 | 2.473 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 3.403245e-03 | 2.468 |
| R-HSA-162909 | Host Interactions of HIV factors | 3.492047e-03 | 2.457 |
| R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptor... | 4.091133e-03 | 2.388 |
| R-HSA-186797 | Signaling by PDGF | 3.917348e-03 | 2.407 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 4.158237e-03 | 2.381 |
| R-HSA-5687868 | Defective SFTPA2 causes IPF | 4.461374e-03 | 2.351 |
| R-HSA-180292 | GAB1 signalosome | 4.879341e-03 | 2.312 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 4.477137e-03 | 2.349 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 4.477137e-03 | 2.349 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 4.879341e-03 | 2.312 |
| R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK | 5.297596e-03 | 2.276 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 6.181672e-03 | 2.209 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 6.181672e-03 | 2.209 |
| R-HSA-392170 | ADP signalling through P2Y purinoceptor 12 | 6.181672e-03 | 2.209 |
| R-HSA-8939211 | ESR-mediated signaling | 5.979860e-03 | 2.223 |
| R-HSA-112316 | Neuronal System | 6.260810e-03 | 2.203 |
| R-HSA-5683057 | MAPK family signaling cascades | 6.070225e-03 | 2.217 |
| R-HSA-216083 | Integrin cell surface interactions | 6.904988e-03 | 2.161 |
| R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus | 7.128200e-03 | 2.147 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 7.128200e-03 | 2.147 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 7.677062e-03 | 2.115 |
| R-HSA-9636467 | Blockage of phagosome acidification | 8.903119e-03 | 2.050 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 9.204023e-03 | 2.036 |
| R-HSA-9927432 | Developmental Lineage of Mammary Gland Myoepithelial Cells | 1.091638e-02 | 1.962 |
| R-HSA-1643685 | Disease | 1.165013e-02 | 1.934 |
| R-HSA-162582 | Signal Transduction | 1.204328e-02 | 1.919 |
| R-HSA-168255 | Influenza Infection | 1.212513e-02 | 1.916 |
| R-HSA-182971 | EGFR downregulation | 1.212992e-02 | 1.916 |
| R-HSA-9820960 | Respiratory syncytial virus (RSV) attachment and entry | 1.212992e-02 | 1.916 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.275714e-02 | 1.894 |
| R-HSA-9824446 | Viral Infection Pathways | 1.276813e-02 | 1.894 |
| R-HSA-390522 | Striated Muscle Contraction | 1.405547e-02 | 1.852 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 1.506599e-02 | 1.822 |
| R-HSA-168898 | Toll-like Receptor Cascades | 1.474580e-02 | 1.831 |
| R-HSA-392518 | Signal amplification | 1.472485e-02 | 1.832 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 1.404952e-02 | 1.852 |
| R-HSA-9682385 | FLT3 signaling in disease | 1.610411e-02 | 1.793 |
| R-HSA-8875878 | MET promotes cell motility | 1.753652e-02 | 1.756 |
| R-HSA-451927 | Interleukin-2 family signaling | 1.902104e-02 | 1.721 |
| R-HSA-991365 | Activation of GABAB receptors | 2.134331e-02 | 1.671 |
| R-HSA-977444 | GABA B receptor activation | 2.134331e-02 | 1.671 |
| R-HSA-8865999 | MET activates PTPN11 | 2.211143e-02 | 1.655 |
| R-HSA-1251932 | PLCG1 events in ERBB2 signaling | 2.647551e-02 | 1.577 |
| R-HSA-2132295 | MHC class II antigen presentation | 2.377099e-02 | 1.624 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 2.332727e-02 | 1.632 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 2.332727e-02 | 1.632 |
| R-HSA-9634597 | GPER1 signaling | 2.631938e-02 | 1.580 |
| R-HSA-162906 | HIV Infection | 2.498037e-02 | 1.602 |
| R-HSA-9660821 | ADORA2B mediated anti-inflammatory cytokines production | 2.377720e-02 | 1.624 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 2.295371e-02 | 1.639 |
| R-HSA-75153 | Apoptotic execution phase | 2.461272e-02 | 1.609 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 2.864505e-02 | 1.543 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 2.895410e-02 | 1.538 |
| R-HSA-9927353 | Co-inhibition by BTLA | 3.082038e-02 | 1.511 |
| R-HSA-9017802 | Noncanonical activation of NOTCH3 | 3.514613e-02 | 1.454 |
| R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer | 3.514613e-02 | 1.454 |
| R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR | 3.514613e-02 | 1.454 |
| R-HSA-8857538 | PTK6 promotes HIF1A stabilization | 3.945284e-02 | 1.404 |
| R-HSA-9645135 | STAT5 Activation | 3.945284e-02 | 1.404 |
| R-HSA-5619070 | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | 3.945284e-02 | 1.404 |
| R-HSA-2562578 | TRIF-mediated programmed cell death | 4.374059e-02 | 1.359 |
| R-HSA-112412 | SOS-mediated signalling | 4.374059e-02 | 1.359 |
| R-HSA-212718 | EGFR interacts with phospholipase C-gamma | 4.800947e-02 | 1.319 |
| R-HSA-8875656 | MET receptor recycling | 4.800947e-02 | 1.319 |
| R-HSA-9028335 | Activated NTRK2 signals through PI3K | 4.800947e-02 | 1.319 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 5.649092e-02 | 1.248 |
| R-HSA-433692 | Proton-coupled monocarboxylate transport | 6.489785e-02 | 1.188 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 6.489785e-02 | 1.188 |
| R-HSA-177504 | Retrograde neurotrophin signalling | 7.736993e-02 | 1.111 |
| R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex | 8.149072e-02 | 1.089 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 8.559336e-02 | 1.068 |
| R-HSA-5654710 | PI-3K cascade:FGFR3 | 1.018240e-01 | 0.992 |
| R-HSA-937041 | IKK complex recruitment mediated by RIP1 | 1.018240e-01 | 0.992 |
| R-HSA-5654720 | PI-3K cascade:FGFR4 | 1.058371e-01 | 0.975 |
| R-HSA-210991 | Basigin interactions | 1.098325e-01 | 0.959 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 1.098325e-01 | 0.959 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 1.138102e-01 | 0.944 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 1.138102e-01 | 0.944 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 1.138102e-01 | 0.944 |
| R-HSA-5654689 | PI-3K cascade:FGFR1 | 1.177705e-01 | 0.929 |
| R-HSA-350054 | Notch-HLH transcription pathway | 1.177705e-01 | 0.929 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 1.256387e-01 | 0.901 |
| R-HSA-5654695 | PI-3K cascade:FGFR2 | 1.295468e-01 | 0.888 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 1.488305e-01 | 0.827 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 1.526364e-01 | 0.816 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 1.526364e-01 | 0.816 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 5.129871e-02 | 1.290 |
| R-HSA-380287 | Centrosome maturation | 5.356029e-02 | 1.271 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 7.032838e-02 | 1.153 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 7.411975e-02 | 1.130 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 7.539800e-02 | 1.123 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 8.058097e-02 | 1.094 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 8.189377e-02 | 1.087 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 8.587181e-02 | 1.066 |
| R-HSA-192823 | Viral mRNA Translation | 9.262896e-02 | 1.033 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 9.953629e-02 | 1.002 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.009349e-01 | 0.996 |
| R-HSA-177929 | Signaling by EGFR | 3.360367e-02 | 1.474 |
| R-HSA-68962 | Activation of the pre-replicative complex | 1.488305e-01 | 0.827 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 8.967794e-02 | 1.047 |
| R-HSA-389359 | CD28 dependent Vav1 pathway | 7.323090e-02 | 1.135 |
| R-HSA-912526 | Interleukin receptor SHC signaling | 1.217133e-01 | 0.915 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 1.526364e-01 | 0.816 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.065841e-01 | 0.972 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 1.499918e-01 | 0.824 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 3.514613e-02 | 1.454 |
| R-HSA-8851907 | MET activates PI3K/AKT signaling | 4.374059e-02 | 1.359 |
| R-HSA-156902 | Peptide chain elongation | 7.032838e-02 | 1.153 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 1.065841e-01 | 0.972 |
| R-HSA-9948299 | Ribosome-associated quality control | 1.528691e-01 | 0.816 |
| R-HSA-164940 | Nef mediated downregulation of MHC class I complex cell surface expression | 4.800947e-02 | 1.319 |
| R-HSA-8941856 | RUNX3 regulates NOTCH signaling | 6.907357e-02 | 1.161 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 1.009349e-01 | 0.996 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 3.579021e-02 | 1.446 |
| R-HSA-2424491 | DAP12 signaling | 1.488305e-01 | 0.827 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 8.149072e-02 | 1.089 |
| R-HSA-72764 | Eukaryotic Translation Termination | 8.189377e-02 | 1.087 |
| R-HSA-74749 | Signal attenuation | 5.649092e-02 | 1.248 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 1.152136e-01 | 0.938 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 1.152136e-01 | 0.938 |
| R-HSA-176974 | Unwinding of DNA | 5.225955e-02 | 1.282 |
| R-HSA-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | 5.649092e-02 | 1.248 |
| R-HSA-9034864 | Activated NTRK3 signals through RAS | 6.070366e-02 | 1.217 |
| R-HSA-192905 | vRNP Assembly | 6.070366e-02 | 1.217 |
| R-HSA-9026519 | Activated NTRK2 signals through RAS | 6.489785e-02 | 1.188 |
| R-HSA-8866427 | VLDLR internalisation and degradation | 6.907357e-02 | 1.161 |
| R-HSA-9027284 | Erythropoietin activates RAS | 8.149072e-02 | 1.089 |
| R-HSA-5654704 | SHC-mediated cascade:FGFR3 | 1.098325e-01 | 0.959 |
| R-HSA-5654719 | SHC-mediated cascade:FGFR4 | 1.138102e-01 | 0.944 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 1.217133e-01 | 0.915 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 1.256387e-01 | 0.901 |
| R-HSA-5654688 | SHC-mediated cascade:FGFR1 | 1.256387e-01 | 0.901 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 1.334377e-01 | 0.875 |
| R-HSA-5654699 | SHC-mediated cascade:FGFR2 | 1.373114e-01 | 0.862 |
| R-HSA-5654708 | Downstream signaling of activated FGFR3 | 1.450078e-01 | 0.839 |
| R-HSA-5654716 | Downstream signaling of activated FGFR4 | 1.488305e-01 | 0.827 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 7.668333e-02 | 1.115 |
| R-HSA-912631 | Regulation of signaling by CBL | 1.018240e-01 | 0.992 |
| R-HSA-9711097 | Cellular response to starvation | 4.462013e-02 | 1.350 |
| R-HSA-6807004 | Negative regulation of MET activity | 1.058371e-01 | 0.975 |
| R-HSA-977443 | GABA receptor activation | 3.750751e-02 | 1.426 |
| R-HSA-6806834 | Signaling by MET | 5.936568e-02 | 1.226 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 3.862241e-02 | 1.413 |
| R-HSA-8851805 | MET activates RAS signaling | 6.907357e-02 | 1.161 |
| R-HSA-2428933 | SHC-related events triggered by IGF1R | 6.907357e-02 | 1.161 |
| R-HSA-5099900 | WNT5A-dependent internalization of FZD4 | 8.559336e-02 | 1.068 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 1.334377e-01 | 0.875 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 1.138102e-01 | 0.944 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 9.779318e-02 | 1.010 |
| R-HSA-74752 | Signaling by Insulin receptor | 7.668333e-02 | 1.115 |
| R-HSA-5655291 | Signaling by FGFR4 in disease | 7.736993e-02 | 1.111 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 9.779318e-02 | 1.010 |
| R-HSA-77387 | Insulin receptor recycling | 1.411681e-01 | 0.850 |
| R-HSA-68877 | Mitotic Prometaphase | 6.975169e-02 | 1.156 |
| R-HSA-9842663 | Signaling by LTK | 6.907357e-02 | 1.161 |
| R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 | 6.907357e-02 | 1.161 |
| R-HSA-9673770 | Signaling by PDGFRA extracellular domain mutants | 8.149072e-02 | 1.089 |
| R-HSA-9673767 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants | 8.149072e-02 | 1.089 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 8.967794e-02 | 1.047 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.411681e-01 | 0.850 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 1.450078e-01 | 0.839 |
| R-HSA-2408557 | Selenocysteine synthesis | 8.990753e-02 | 1.046 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 6.907357e-02 | 1.161 |
| R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic... | 8.559336e-02 | 1.068 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 1.138102e-01 | 0.944 |
| R-HSA-399719 | Trafficking of AMPA receptors | 1.526364e-01 | 0.816 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 5.018129e-02 | 1.299 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 9.399873e-02 | 1.027 |
| R-HSA-5655332 | Signaling by FGFR3 in disease | 1.373114e-01 | 0.862 |
| R-HSA-8983432 | Interleukin-15 signaling | 6.907357e-02 | 1.161 |
| R-HSA-5654706 | FRS-mediated FGFR3 signaling | 1.138102e-01 | 0.944 |
| R-HSA-5654712 | FRS-mediated FGFR4 signaling | 1.177705e-01 | 0.929 |
| R-HSA-5654693 | FRS-mediated FGFR1 signaling | 1.295468e-01 | 0.888 |
| R-HSA-5654700 | FRS-mediated FGFR2 signaling | 1.411681e-01 | 0.850 |
| R-HSA-210993 | Tie2 Signaling | 9.779318e-02 | 1.010 |
| R-HSA-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen... | 3.514613e-02 | 1.454 |
| R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | 7.736993e-02 | 1.111 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 1.058371e-01 | 0.975 |
| R-HSA-167044 | Signalling to RAS | 1.098325e-01 | 0.959 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 8.149072e-02 | 1.089 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 1.177705e-01 | 0.929 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 3.952172e-02 | 1.403 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 1.138102e-01 | 0.944 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 1.009349e-01 | 0.996 |
| R-HSA-9006335 | Signaling by Erythropoietin | 1.450078e-01 | 0.839 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 1.373114e-01 | 0.862 |
| R-HSA-8964038 | LDL clearance | 1.177705e-01 | 0.929 |
| R-HSA-373760 | L1CAM interactions | 1.152136e-01 | 0.938 |
| R-HSA-9033500 | TYSND1 cleaves peroxisomal proteins | 3.514613e-02 | 1.454 |
| R-HSA-1679131 | Trafficking and processing of endosomal TLR | 6.907357e-02 | 1.161 |
| R-HSA-157118 | Signaling by NOTCH | 1.110355e-01 | 0.955 |
| R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription | 1.488305e-01 | 0.827 |
| R-HSA-69190 | DNA strand elongation | 1.564255e-01 | 0.806 |
| R-HSA-1433559 | Regulation of KIT signaling | 7.736993e-02 | 1.111 |
| R-HSA-186763 | Downstream signal transduction | 1.526364e-01 | 0.816 |
| R-HSA-112040 | G-protein mediated events | 4.473197e-02 | 1.349 |
| R-HSA-1474244 | Extracellular matrix organization | 7.252791e-02 | 1.139 |
| R-HSA-140534 | Caspase activation via Death Receptors in the presence of ligand | 8.559336e-02 | 1.068 |
| R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription | 1.098325e-01 | 0.959 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 1.138102e-01 | 0.944 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 4.800947e-02 | 1.319 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 8.149072e-02 | 1.089 |
| R-HSA-2028269 | Signaling by Hippo | 9.374451e-02 | 1.028 |
| R-HSA-9845614 | Sphingolipid catabolism | 1.334377e-01 | 0.875 |
| R-HSA-9674555 | Signaling by CSF3 (G-CSF) | 1.450078e-01 | 0.839 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 1.018240e-01 | 0.992 |
| R-HSA-445144 | Signal transduction by L1 | 1.058371e-01 | 0.975 |
| R-HSA-111885 | Opioid Signalling | 9.399873e-02 | 1.027 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 1.217133e-01 | 0.915 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 3.360367e-02 | 1.474 |
| R-HSA-9669938 | Signaling by KIT in disease | 1.177705e-01 | 0.929 |
| R-HSA-418597 | G alpha (z) signalling events | 3.265431e-02 | 1.486 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 1.497704e-01 | 0.825 |
| R-HSA-422475 | Axon guidance | 4.107811e-02 | 1.386 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 1.564255e-01 | 0.806 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 1.108762e-01 | 0.955 |
| R-HSA-9675108 | Nervous system development | 5.290709e-02 | 1.276 |
| R-HSA-3000170 | Syndecan interactions | 1.217133e-01 | 0.915 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 9.953629e-02 | 1.002 |
| R-HSA-9824443 | Parasitic Infection Pathways | 1.520988e-01 | 0.818 |
| R-HSA-9658195 | Leishmania infection | 1.520988e-01 | 0.818 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 9.996171e-02 | 1.000 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 1.334377e-01 | 0.875 |
| R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway | 1.334377e-01 | 0.875 |
| R-HSA-9700206 | Signaling by ALK in cancer | 9.953629e-02 | 1.002 |
| R-HSA-196791 | Vitamin D (calciferol) metabolism | 9.779318e-02 | 1.010 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 1.344853e-01 | 0.871 |
| R-HSA-1989781 | PPARA activates gene expression | 4.277450e-02 | 1.369 |
| R-HSA-5663205 | Infectious disease | 3.912767e-02 | 1.408 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 4.400054e-02 | 1.357 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 8.453928e-02 | 1.073 |
| R-HSA-8953897 | Cellular responses to stimuli | 1.488626e-01 | 0.827 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 4.261845e-02 | 1.370 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 1.564255e-01 | 0.806 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 5.288685e-02 | 1.277 |
| R-HSA-109581 | Apoptosis | 4.714214e-02 | 1.327 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 1.513181e-01 | 0.820 |
| R-HSA-9020591 | Interleukin-12 signaling | 5.470426e-02 | 1.262 |
| R-HSA-9679506 | SARS-CoV Infections | 1.154665e-01 | 0.938 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 7.918321e-02 | 1.101 |
| R-HSA-5357801 | Programmed Cell Death | 8.011104e-02 | 1.096 |
| R-HSA-447115 | Interleukin-12 family signaling | 6.907935e-02 | 1.161 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 1.601978e-01 | 0.795 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 1.601978e-01 | 0.795 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 1.601978e-01 | 0.795 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.601978e-01 | 0.795 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 1.601978e-01 | 0.795 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 1.601978e-01 | 0.795 |
| R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity | 1.601978e-01 | 0.795 |
| R-HSA-354192 | Integrin signaling | 1.601978e-01 | 0.795 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 1.606711e-01 | 0.794 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 1.639536e-01 | 0.785 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 1.639536e-01 | 0.785 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 1.639536e-01 | 0.785 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 1.676928e-01 | 0.775 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 1.676928e-01 | 0.775 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 1.676928e-01 | 0.775 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.676928e-01 | 0.775 |
| R-HSA-180746 | Nuclear import of Rev protein | 1.676928e-01 | 0.775 |
| R-HSA-166520 | Signaling by NTRKs | 1.701292e-01 | 0.769 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 1.714155e-01 | 0.766 |
| R-HSA-5654696 | Downstream signaling of activated FGFR2 | 1.714155e-01 | 0.766 |
| R-HSA-5654687 | Downstream signaling of activated FGFR1 | 1.714155e-01 | 0.766 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 1.714155e-01 | 0.766 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 1.714155e-01 | 0.766 |
| R-HSA-187687 | Signalling to ERKs | 1.714155e-01 | 0.766 |
| R-HSA-9679191 | Potential therapeutics for SARS | 1.733031e-01 | 0.761 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 1.733031e-01 | 0.761 |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | 1.751217e-01 | 0.757 |
| R-HSA-8853659 | RET signaling | 1.751217e-01 | 0.757 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 1.764869e-01 | 0.753 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 1.788117e-01 | 0.748 |
| R-HSA-419037 | NCAM1 interactions | 1.788117e-01 | 0.748 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 1.788117e-01 | 0.748 |
| R-HSA-390247 | Beta-oxidation of very long chain fatty acids | 1.788117e-01 | 0.748 |
| R-HSA-8948216 | Collagen chain trimerization | 1.788117e-01 | 0.748 |
| R-HSA-2262752 | Cellular responses to stress | 1.818521e-01 | 0.740 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 1.824853e-01 | 0.739 |
| R-HSA-2046106 | alpha-linolenic acid (ALA) metabolism | 1.824853e-01 | 0.739 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 1.861427e-01 | 0.730 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 1.861427e-01 | 0.730 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 1.861427e-01 | 0.730 |
| R-HSA-9006936 | Signaling by TGFB family members | 1.893132e-01 | 0.723 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 1.897840e-01 | 0.722 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 1.897840e-01 | 0.722 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 1.897840e-01 | 0.722 |
| R-HSA-5260271 | Diseases of Immune System | 1.897840e-01 | 0.722 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 1.897840e-01 | 0.722 |
| R-HSA-9607240 | FLT3 Signaling | 1.934093e-01 | 0.714 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 1.934093e-01 | 0.714 |
| R-HSA-2408522 | Selenoamino acid metabolism | 1.957752e-01 | 0.708 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 1.970185e-01 | 0.705 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 1.970185e-01 | 0.705 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 2.006118e-01 | 0.698 |
| R-HSA-5619102 | SLC transporter disorders | 2.006406e-01 | 0.698 |
| R-HSA-5654743 | Signaling by FGFR4 | 2.041893e-01 | 0.690 |
| R-HSA-1433557 | Signaling by SCF-KIT | 2.041893e-01 | 0.690 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 2.041893e-01 | 0.690 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 2.071504e-01 | 0.684 |
| R-HSA-2172127 | DAP12 interactions | 2.077509e-01 | 0.682 |
| R-HSA-418555 | G alpha (s) signalling events | 2.087816e-01 | 0.680 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 2.112969e-01 | 0.675 |
| R-HSA-5654741 | Signaling by FGFR3 | 2.112969e-01 | 0.675 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 2.112969e-01 | 0.675 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 2.120482e-01 | 0.674 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 2.120482e-01 | 0.674 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 2.148272e-01 | 0.668 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 2.148272e-01 | 0.668 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 2.148272e-01 | 0.668 |
| R-HSA-437239 | Recycling pathway of L1 | 2.183419e-01 | 0.661 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 2.183419e-01 | 0.661 |
| R-HSA-2046104 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism | 2.183419e-01 | 0.661 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 2.218411e-01 | 0.654 |
| R-HSA-389356 | Co-stimulation by CD28 | 2.218411e-01 | 0.654 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 2.253248e-01 | 0.647 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 2.285269e-01 | 0.641 |
| R-HSA-5655253 | Signaling by FGFR2 in disease | 2.287932e-01 | 0.641 |
| R-HSA-109704 | PI3K Cascade | 2.287932e-01 | 0.641 |
| R-HSA-69275 | G2/M Transition | 2.333949e-01 | 0.632 |
| R-HSA-68949 | Orc1 removal from chromatin | 2.356841e-01 | 0.628 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 2.366930e-01 | 0.626 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 2.366930e-01 | 0.626 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 2.391067e-01 | 0.621 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 2.391067e-01 | 0.621 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 2.391067e-01 | 0.621 |
| R-HSA-5617833 | Cilium Assembly | 2.399938e-01 | 0.620 |
| R-HSA-72649 | Translation initiation complex formation | 2.425142e-01 | 0.615 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 2.425142e-01 | 0.615 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 2.466029e-01 | 0.608 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 2.492841e-01 | 0.603 |
| R-HSA-5654736 | Signaling by FGFR1 | 2.492841e-01 | 0.603 |
| R-HSA-9609690 | HCMV Early Events | 2.499104e-01 | 0.602 |
| R-HSA-112399 | IRS-mediated signalling | 2.526467e-01 | 0.597 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 2.526467e-01 | 0.597 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 2.559944e-01 | 0.592 |
| R-HSA-428157 | Sphingolipid metabolism | 2.581857e-01 | 0.588 |
| R-HSA-194441 | Metabolism of non-coding RNA | 2.593273e-01 | 0.586 |
| R-HSA-191859 | snRNP Assembly | 2.593273e-01 | 0.586 |
| R-HSA-9033241 | Peroxisomal protein import | 2.593273e-01 | 0.586 |
| R-HSA-186712 | Regulation of beta-cell development | 2.593273e-01 | 0.586 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 2.593273e-01 | 0.586 |
| R-HSA-376176 | Signaling by ROBO receptors | 2.614977e-01 | 0.583 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 2.626455e-01 | 0.581 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 2.626455e-01 | 0.581 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 2.626455e-01 | 0.581 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 2.626455e-01 | 0.581 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 2.626455e-01 | 0.581 |
| R-HSA-72172 | mRNA Splicing | 2.648103e-01 | 0.577 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 2.659490e-01 | 0.575 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 2.659490e-01 | 0.575 |
| R-HSA-9793380 | Formation of paraxial mesoderm | 2.659490e-01 | 0.575 |
| R-HSA-211976 | Endogenous sterols | 2.659490e-01 | 0.575 |
| R-HSA-1442490 | Collagen degradation | 2.659490e-01 | 0.575 |
| R-HSA-69278 | Cell Cycle, Mitotic | 2.677965e-01 | 0.572 |
| R-HSA-68886 | M Phase | 2.691952e-01 | 0.570 |
| R-HSA-6784531 | tRNA processing in the nucleus | 2.692380e-01 | 0.570 |
| R-HSA-9707616 | Heme signaling | 2.692380e-01 | 0.570 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 2.725124e-01 | 0.565 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 2.725124e-01 | 0.565 |
| R-HSA-74751 | Insulin receptor signalling cascade | 2.757723e-01 | 0.559 |
| R-HSA-2428924 | IGF1R signaling cascade | 2.757723e-01 | 0.559 |
| R-HSA-211981 | Xenobiotics | 2.757723e-01 | 0.559 |
| R-HSA-397014 | Muscle contraction | 2.780618e-01 | 0.556 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 2.790178e-01 | 0.554 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 2.797178e-01 | 0.553 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 2.822490e-01 | 0.549 |
| R-HSA-388396 | GPCR downstream signalling | 2.826888e-01 | 0.549 |
| R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 2.886686e-01 | 0.540 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 2.886686e-01 | 0.540 |
| R-HSA-9840310 | Glycosphingolipid catabolism | 2.950316e-01 | 0.530 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 2.981920e-01 | 0.526 |
| R-HSA-3000178 | ECM proteoglycans | 2.981920e-01 | 0.526 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 2.981920e-01 | 0.526 |
| R-HSA-418594 | G alpha (i) signalling events | 2.996410e-01 | 0.523 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 3.013384e-01 | 0.521 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 3.013384e-01 | 0.521 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 3.044709e-01 | 0.516 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 3.044709e-01 | 0.516 |
| R-HSA-9749641 | Aspirin ADME | 3.044709e-01 | 0.516 |
| R-HSA-1226099 | Signaling by FGFR in disease | 3.075896e-01 | 0.512 |
| R-HSA-9013694 | Signaling by NOTCH4 | 3.075896e-01 | 0.512 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 3.075896e-01 | 0.512 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 3.106945e-01 | 0.508 |
| R-HSA-917937 | Iron uptake and transport | 3.106945e-01 | 0.508 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 3.106945e-01 | 0.508 |
| R-HSA-72312 | rRNA processing | 3.111110e-01 | 0.507 |
| R-HSA-1980143 | Signaling by NOTCH1 | 3.137856e-01 | 0.503 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 3.193358e-01 | 0.496 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 3.199270e-01 | 0.495 |
| R-HSA-4086400 | PCP/CE pathway | 3.199270e-01 | 0.495 |
| R-HSA-5654738 | Signaling by FGFR2 | 3.260141e-01 | 0.487 |
| R-HSA-449147 | Signaling by Interleukins | 3.272355e-01 | 0.485 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 3.320475e-01 | 0.479 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 3.357175e-01 | 0.474 |
| R-HSA-8953854 | Metabolism of RNA | 3.364970e-01 | 0.473 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 3.380276e-01 | 0.471 |
| R-HSA-390918 | Peroxisomal lipid metabolism | 3.380276e-01 | 0.471 |
| R-HSA-9609646 | HCMV Infection | 3.406115e-01 | 0.468 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 3.439550e-01 | 0.463 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 3.439550e-01 | 0.463 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 3.468990e-01 | 0.460 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 3.498300e-01 | 0.456 |
| R-HSA-199991 | Membrane Trafficking | 3.507306e-01 | 0.455 |
| R-HSA-69620 | Cell Cycle Checkpoints | 3.536094e-01 | 0.451 |
| R-HSA-1236974 | ER-Phagosome pathway | 3.556531e-01 | 0.449 |
| R-HSA-372790 | Signaling by GPCR | 3.561918e-01 | 0.448 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 3.585453e-01 | 0.445 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 3.614247e-01 | 0.442 |
| R-HSA-9734767 | Developmental Cell Lineages | 3.616902e-01 | 0.442 |
| R-HSA-416476 | G alpha (q) signalling events | 3.633021e-01 | 0.440 |
| R-HSA-381070 | IRE1alpha activates chaperones | 3.642914e-01 | 0.439 |
| R-HSA-168256 | Immune System | 3.649630e-01 | 0.438 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 3.650668e-01 | 0.438 |
| R-HSA-391251 | Protein folding | 3.671454e-01 | 0.435 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 3.671454e-01 | 0.435 |
| R-HSA-2682334 | EPH-Ephrin signaling | 3.671454e-01 | 0.435 |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge... | 3.699868e-01 | 0.432 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 3.699868e-01 | 0.432 |
| R-HSA-1474290 | Collagen formation | 3.728156e-01 | 0.429 |
| R-HSA-9954709 | Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide | 3.784356e-01 | 0.422 |
| R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization | 3.812270e-01 | 0.419 |
| R-HSA-1266738 | Developmental Biology | 3.842082e-01 | 0.415 |
| R-HSA-190236 | Signaling by FGFR | 3.867727e-01 | 0.413 |
| R-HSA-422356 | Regulation of insulin secretion | 3.867727e-01 | 0.413 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 3.922693e-01 | 0.406 |
| R-HSA-70171 | Glycolysis | 3.922693e-01 | 0.406 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.977174e-01 | 0.400 |
| R-HSA-168249 | Innate Immune System | 3.996601e-01 | 0.398 |
| R-HSA-9833110 | RSV-host interactions | 4.057994e-01 | 0.392 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 4.111278e-01 | 0.386 |
| R-HSA-1640170 | Cell Cycle | 4.120138e-01 | 0.385 |
| R-HSA-69239 | Synthesis of DNA | 4.137744e-01 | 0.383 |
| R-HSA-211000 | Gene Silencing by RNA | 4.137744e-01 | 0.383 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 4.164092e-01 | 0.380 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 4.164092e-01 | 0.380 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 4.190323e-01 | 0.378 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 4.190323e-01 | 0.378 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 4.190323e-01 | 0.378 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 4.216438e-01 | 0.375 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 4.216438e-01 | 0.375 |
| R-HSA-2871796 | FCERI mediated MAPK activation | 4.268321e-01 | 0.370 |
| R-HSA-1483249 | Inositol phosphate metabolism | 4.268321e-01 | 0.370 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 4.294090e-01 | 0.367 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 4.294090e-01 | 0.367 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 4.319745e-01 | 0.365 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 4.370714e-01 | 0.359 |
| R-HSA-2871809 | FCERI mediated Ca+2 mobilization | 4.396029e-01 | 0.357 |
| R-HSA-70326 | Glucose metabolism | 4.446323e-01 | 0.352 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 4.496172e-01 | 0.347 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 4.496172e-01 | 0.347 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 4.507609e-01 | 0.346 |
| R-HSA-68875 | Mitotic Prophase | 4.520930e-01 | 0.345 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 4.545579e-01 | 0.342 |
| R-HSA-3371556 | Cellular response to heat stress | 4.545579e-01 | 0.342 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 4.545579e-01 | 0.342 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 4.552654e-01 | 0.342 |
| R-HSA-1660662 | Glycosphingolipid metabolism | 4.594549e-01 | 0.338 |
| R-HSA-69206 | G1/S Transition | 4.667193e-01 | 0.331 |
| R-HSA-69481 | G2/M Checkpoints | 4.715086e-01 | 0.327 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 4.971014e-01 | 0.304 |
| R-HSA-163685 | Integration of energy metabolism | 4.971014e-01 | 0.304 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 5.038666e-01 | 0.298 |
| R-HSA-9664407 | Parasite infection | 5.061016e-01 | 0.296 |
| R-HSA-9664417 | Leishmania phagocytosis | 5.061016e-01 | 0.296 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 5.061016e-01 | 0.296 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 5.083267e-01 | 0.294 |
| R-HSA-5653656 | Vesicle-mediated transport | 5.111266e-01 | 0.291 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 5.127473e-01 | 0.290 |
| R-HSA-556833 | Metabolism of lipids | 5.176327e-01 | 0.286 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 5.214713e-01 | 0.283 |
| R-HSA-1280218 | Adaptive Immune System | 5.232525e-01 | 0.281 |
| R-HSA-69242 | S Phase | 5.257753e-01 | 0.279 |
| R-HSA-9758941 | Gastrulation | 5.279130e-01 | 0.277 |
| R-HSA-69306 | DNA Replication | 5.363691e-01 | 0.271 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 5.363691e-01 | 0.271 |
| R-HSA-9609507 | Protein localization | 5.363691e-01 | 0.271 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 5.384597e-01 | 0.269 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 5.384597e-01 | 0.269 |
| R-HSA-74160 | Gene expression (Transcription) | 5.387422e-01 | 0.269 |
| R-HSA-913531 | Interferon Signaling | 5.420963e-01 | 0.266 |
| R-HSA-9610379 | HCMV Late Events | 5.446758e-01 | 0.264 |
| R-HSA-162587 | HIV Life Cycle | 5.446758e-01 | 0.264 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 5.467295e-01 | 0.262 |
| R-HSA-877300 | Interferon gamma signaling | 5.487740e-01 | 0.261 |
| R-HSA-9824439 | Bacterial Infection Pathways | 5.514458e-01 | 0.258 |
| R-HSA-2467813 | Separation of Sister Chromatids | 5.588609e-01 | 0.253 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 5.648060e-01 | 0.248 |
| R-HSA-72306 | tRNA processing | 5.726100e-01 | 0.242 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 5.802760e-01 | 0.236 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.821712e-01 | 0.235 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 5.821712e-01 | 0.235 |
| R-HSA-5668914 | Diseases of metabolism | 5.986583e-01 | 0.223 |
| R-HSA-72766 | Translation | 6.011037e-01 | 0.221 |
| R-HSA-375276 | Peptide ligand-binding receptors | 6.024696e-01 | 0.220 |
| R-HSA-983712 | Ion channel transport | 6.078346e-01 | 0.216 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 6.319424e-01 | 0.199 |
| R-HSA-68882 | Mitotic Anaphase | 6.545875e-01 | 0.184 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 6.561514e-01 | 0.183 |
| R-HSA-9748784 | Drug ADME | 6.577083e-01 | 0.182 |
| R-HSA-392499 | Metabolism of proteins | 6.618482e-01 | 0.179 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 7.119882e-01 | 0.148 |
| R-HSA-212436 | Generic Transcription Pathway | 7.167588e-01 | 0.145 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 7.394357e-01 | 0.131 |
| R-HSA-446728 | Cell junction organization | 7.394357e-01 | 0.131 |
| R-HSA-195721 | Signaling by WNT | 7.621402e-01 | 0.118 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 7.846033e-01 | 0.105 |
| R-HSA-8957322 | Metabolism of steroids | 7.887610e-01 | 0.103 |
| R-HSA-73857 | RNA Polymerase II Transcription | 7.918567e-01 | 0.101 |
| R-HSA-73894 | DNA Repair | 8.208319e-01 | 0.086 |
| R-HSA-382551 | Transport of small molecules | 8.331376e-01 | 0.079 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 8.394929e-01 | 0.076 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 8.473922e-01 | 0.072 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 8.494792e-01 | 0.071 |
| R-HSA-8978868 | Fatty acid metabolism | 8.562346e-01 | 0.067 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 8.847197e-01 | 0.053 |
| R-HSA-6798695 | Neutrophil degranulation | 8.857772e-01 | 0.053 |
| R-HSA-211859 | Biological oxidations | 9.157845e-01 | 0.038 |
| R-HSA-500792 | GPCR ligand binding | 9.379890e-01 | 0.028 |
| R-HSA-1430728 | Metabolism | 9.663149e-01 | 0.015 |
| R-HSA-597592 | Post-translational protein modification | 9.841942e-01 | 0.007 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
PDHK3_TYR |
0.717 | 0.182 | 4 | 0.619 |
YES1 |
0.706 | 0.067 | -1 | 0.736 |
PDHK4_TYR |
0.705 | 0.090 | 2 | 0.843 |
MAP2K7_TYR |
0.703 | -0.072 | 2 | 0.846 |
RET |
0.702 | -0.035 | 1 | 0.645 |
SRMS |
0.702 | 0.039 | 1 | 0.632 |
TYK2 |
0.702 | -0.072 | 1 | 0.634 |
TXK |
0.702 | 0.097 | 1 | 0.568 |
EPHA6 |
0.701 | -0.027 | -1 | 0.703 |
TESK1_TYR |
0.701 | -0.083 | 3 | 0.663 |
PDHK1_TYR |
0.701 | 0.015 | -1 | 0.691 |
TEC |
0.700 | 0.055 | -1 | 0.686 |
EPHB4 |
0.700 | -0.013 | -1 | 0.690 |
FER |
0.700 | -0.003 | 1 | 0.647 |
EPHB1 |
0.700 | 0.008 | 1 | 0.633 |
PINK1_TYR |
0.700 | -0.090 | 1 | 0.634 |
EPHB2 |
0.700 | 0.034 | -1 | 0.688 |
MAP2K6_TYR |
0.700 | 0.016 | -1 | 0.677 |
BMPR2_TYR |
0.699 | -0.010 | -1 | 0.665 |
TYRO3 |
0.699 | -0.058 | 3 | 0.603 |
CSF1R |
0.699 | -0.011 | 3 | 0.616 |
JAK2 |
0.699 | -0.061 | 1 | 0.620 |
MST1R |
0.698 | -0.074 | 3 | 0.623 |
AXL |
0.697 | -0.039 | 3 | 0.632 |
MAP2K4_TYR |
0.696 | -0.100 | -1 | 0.690 |
INSRR |
0.696 | 0.031 | 3 | 0.625 |
EPHB3 |
0.696 | -0.021 | -1 | 0.690 |
BLK |
0.696 | 0.061 | -1 | 0.711 |
ROS1 |
0.696 | -0.079 | 3 | 0.589 |
MERTK |
0.695 | -0.012 | 3 | 0.622 |
ITK |
0.695 | 0.004 | -1 | 0.699 |
PKMYT1_TYR |
0.695 | -0.165 | 3 | 0.638 |
KIT |
0.695 | -0.007 | 3 | 0.624 |
FLT3 |
0.695 | -0.025 | 3 | 0.595 |
HCK |
0.694 | -0.019 | -1 | 0.715 |
DDR1 |
0.694 | -0.104 | 4 | 0.558 |
LCK |
0.694 | 0.018 | -1 | 0.712 |
FGFR1 |
0.694 | -0.042 | 3 | 0.639 |
FGFR2 |
0.694 | -0.034 | 3 | 0.656 |
PDGFRB |
0.693 | -0.058 | 3 | 0.627 |
FYN |
0.693 | 0.067 | -1 | 0.682 |
ABL2 |
0.693 | -0.021 | -1 | 0.682 |
EPHA4 |
0.693 | -0.002 | 2 | 0.776 |
LIMK2_TYR |
0.693 | -0.101 | -3 | 0.783 |
FRK |
0.692 | -0.000 | -1 | 0.718 |
TEK |
0.692 | -0.060 | 3 | 0.590 |
JAK3 |
0.692 | -0.061 | 1 | 0.610 |
BTK |
0.692 | -0.048 | -1 | 0.689 |
TNK2 |
0.690 | -0.057 | 3 | 0.628 |
ALK |
0.690 | -0.044 | 3 | 0.604 |
LIMK1_TYR |
0.690 | -0.160 | 2 | 0.839 |
KDR |
0.690 | -0.035 | 3 | 0.607 |
BMX |
0.689 | -0.010 | -1 | 0.609 |
LTK |
0.689 | -0.044 | 3 | 0.604 |
EPHA1 |
0.689 | -0.058 | 3 | 0.605 |
FGR |
0.688 | -0.051 | 1 | 0.622 |
EPHA7 |
0.688 | -0.027 | 2 | 0.779 |
MET |
0.688 | -0.017 | 3 | 0.621 |
EGFR |
0.688 | 0.033 | 1 | 0.568 |
JAK1 |
0.688 | -0.054 | 1 | 0.585 |
PTK6 |
0.688 | -0.030 | -1 | 0.660 |
ABL1 |
0.687 | -0.060 | -1 | 0.700 |
FGFR3 |
0.687 | -0.022 | 3 | 0.649 |
NTRK2 |
0.687 | -0.068 | 3 | 0.629 |
LYN |
0.686 | -0.009 | 3 | 0.540 |
TNK1 |
0.686 | -0.082 | 3 | 0.573 |
ERBB2 |
0.685 | -0.056 | 1 | 0.627 |
PTK2B |
0.685 | 0.001 | -1 | 0.744 |
EPHA5 |
0.685 | -0.003 | 2 | 0.761 |
SRC |
0.684 | 0.010 | -1 | 0.708 |
EPHA8 |
0.684 | -0.002 | -1 | 0.656 |
NTRK1 |
0.683 | -0.075 | -1 | 0.638 |
NEK10_TYR |
0.683 | -0.086 | 1 | 0.525 |
FGFR4 |
0.683 | 0.002 | -1 | 0.625 |
PDGFRA |
0.683 | -0.129 | 3 | 0.614 |
EPHA3 |
0.682 | -0.058 | 2 | 0.752 |
DDR2 |
0.682 | -0.041 | 3 | 0.640 |
INSR |
0.682 | -0.062 | 3 | 0.578 |
FLT1 |
0.682 | -0.026 | -1 | 0.629 |
TNNI3K_TYR |
0.681 | -0.088 | 1 | 0.631 |
FLT4 |
0.681 | -0.071 | 3 | 0.596 |
CSK |
0.678 | -0.060 | 2 | 0.783 |
WEE1_TYR |
0.675 | -0.113 | -1 | 0.624 |
NTRK3 |
0.675 | -0.086 | -1 | 0.590 |
MATK |
0.673 | -0.073 | -1 | 0.606 |
IGF1R |
0.672 | -0.046 | 3 | 0.543 |
EPHA2 |
0.670 | -0.045 | -1 | 0.612 |
SYK |
0.670 | 0.003 | -1 | 0.573 |
PLK1 |
0.669 | 0.263 | -2 | 0.783 |
ERBB4 |
0.669 | -0.009 | 1 | 0.561 |
PTK2 |
0.669 | -0.014 | -1 | 0.607 |
ACVR2A |
0.668 | 0.228 | -2 | 0.739 |
DSTYK |
0.666 | 0.196 | 2 | 0.857 |
BMPR2 |
0.666 | 0.125 | -2 | 0.699 |
FES |
0.666 | -0.068 | -1 | 0.625 |
COT |
0.666 | 0.211 | 2 | 0.840 |
ACVR2B |
0.665 | 0.195 | -2 | 0.726 |
MUSK |
0.665 | -0.099 | 1 | 0.551 |
ALK4 |
0.664 | 0.091 | -2 | 0.630 |
ALK2 |
0.662 | 0.124 | -2 | 0.621 |
PLK3 |
0.662 | 0.194 | 2 | 0.780 |
TTK |
0.661 | 0.263 | -2 | 0.771 |
TGFBR1 |
0.661 | 0.088 | -2 | 0.611 |
NEK7 |
0.661 | 0.155 | -3 | 0.758 |
PKR |
0.660 | 0.033 | 1 | 0.680 |
CAMK2G |
0.659 | 0.070 | 2 | 0.823 |
ATM |
0.659 | 0.178 | 1 | 0.728 |
PRPK |
0.659 | -0.058 | -1 | 0.689 |
ATR |
0.659 | 0.113 | 1 | 0.734 |
GRK6 |
0.659 | 0.104 | 1 | 0.639 |
TLK2 |
0.659 | 0.168 | 1 | 0.665 |
NEK6 |
0.658 | 0.199 | -2 | 0.748 |
BRAF |
0.658 | 0.026 | -4 | 0.570 |
GRK7 |
0.657 | 0.195 | 1 | 0.605 |
RAF1 |
0.657 | -0.015 | 1 | 0.653 |
ANKRD3 |
0.656 | 0.026 | 1 | 0.650 |
BMPR1B |
0.656 | 0.112 | 1 | 0.518 |
ULK2 |
0.656 | 0.025 | 2 | 0.788 |
TGFBR2 |
0.655 | 0.138 | -2 | 0.720 |
TBK1 |
0.654 | 0.024 | 1 | 0.583 |
HUNK |
0.653 | 0.041 | 2 | 0.829 |
BMPR1A |
0.653 | 0.117 | 1 | 0.520 |
MEK1 |
0.653 | -0.064 | 2 | 0.839 |
NIK |
0.653 | -0.089 | -3 | 0.743 |
MLK1 |
0.653 | 0.029 | 2 | 0.805 |
MEKK2 |
0.652 | 0.037 | 2 | 0.796 |
IKKA |
0.652 | 0.115 | -2 | 0.565 |
PERK |
0.652 | 0.130 | -2 | 0.719 |
CAMLCK |
0.652 | -0.052 | -2 | 0.619 |
NEK5 |
0.652 | 0.015 | 1 | 0.661 |
VRK2 |
0.652 | -0.159 | 1 | 0.659 |
CAMK1B |
0.651 | -0.065 | -3 | 0.704 |
DNAPK |
0.651 | 0.145 | 1 | 0.693 |
MARK4 |
0.651 | 0.023 | 4 | 0.634 |
NEK9 |
0.650 | -0.014 | 2 | 0.824 |
MOS |
0.650 | -0.022 | 1 | 0.597 |
TSSK2 |
0.650 | -0.008 | -5 | 0.637 |
PDHK1 |
0.650 | -0.086 | 1 | 0.658 |
IKKE |
0.649 | 0.019 | 1 | 0.572 |
DAPK2 |
0.649 | -0.091 | -3 | 0.725 |
GRK5 |
0.649 | 0.000 | -3 | 0.758 |
DLK |
0.649 | -0.084 | 1 | 0.647 |
GRK4 |
0.649 | 0.095 | -2 | 0.643 |
YSK4 |
0.648 | -0.027 | 1 | 0.611 |
IKKB |
0.648 | 0.008 | -2 | 0.576 |
ZAP70 |
0.648 | -0.033 | -1 | 0.508 |
TSSK1 |
0.648 | 0.003 | -3 | 0.724 |
HRI |
0.648 | 0.062 | -2 | 0.745 |
LATS1 |
0.648 | 0.046 | -3 | 0.731 |
MST2 |
0.647 | -0.006 | 1 | 0.634 |
NEK2 |
0.647 | -0.021 | 2 | 0.799 |
TAK1 |
0.647 | -0.030 | 1 | 0.633 |
PDHK4 |
0.647 | -0.150 | 1 | 0.651 |
CAMKK1 |
0.647 | -0.046 | -2 | 0.553 |
TLK1 |
0.647 | 0.093 | -2 | 0.709 |
ULK1 |
0.646 | 0.000 | -3 | 0.739 |
SKMLCK |
0.645 | -0.022 | -2 | 0.590 |
FAM20C |
0.645 | 0.135 | 2 | 0.626 |
NEK8 |
0.645 | 0.015 | 2 | 0.808 |
VRK1 |
0.645 | -0.058 | 2 | 0.828 |
MARK2 |
0.645 | 0.036 | 4 | 0.589 |
TTBK2 |
0.645 | 0.020 | 2 | 0.725 |
PKCD |
0.645 | 0.015 | 2 | 0.780 |
MST1 |
0.645 | -0.014 | 1 | 0.640 |
CDC7 |
0.644 | -0.017 | 1 | 0.589 |
MLK4 |
0.644 | 0.065 | 2 | 0.719 |
NEK1 |
0.644 | -0.063 | 1 | 0.654 |
MEKK3 |
0.644 | -0.036 | 1 | 0.622 |
PRP4 |
0.644 | 0.062 | -3 | 0.771 |
MEKK1 |
0.643 | -0.070 | 1 | 0.641 |
GAK |
0.643 | -0.062 | 1 | 0.579 |
PLK4 |
0.643 | 0.074 | 2 | 0.668 |
CLK3 |
0.643 | 0.074 | 1 | 0.630 |
GRK1 |
0.643 | 0.054 | -2 | 0.536 |
WNK1 |
0.643 | -0.064 | -2 | 0.577 |
GCN2 |
0.643 | 0.039 | 2 | 0.809 |
MLK3 |
0.643 | 0.048 | 2 | 0.740 |
NLK |
0.642 | -0.107 | 1 | 0.567 |
MEK5 |
0.642 | -0.152 | 2 | 0.813 |
ALPHAK3 |
0.642 | 0.062 | -1 | 0.600 |
EEF2K |
0.641 | -0.027 | 3 | 0.600 |
CAMKK2 |
0.641 | -0.081 | -2 | 0.542 |
AMPKA1 |
0.641 | -0.054 | -3 | 0.696 |
RIPK3 |
0.641 | -0.084 | 3 | 0.583 |
WNK3 |
0.641 | -0.144 | 1 | 0.654 |
NEK4 |
0.640 | -0.081 | 1 | 0.655 |
SMG1 |
0.640 | 0.068 | 1 | 0.731 |
MLK2 |
0.640 | -0.087 | 2 | 0.792 |
IRE2 |
0.639 | 0.008 | 2 | 0.756 |
MEK2 |
0.639 | -0.093 | 2 | 0.805 |
PKN3 |
0.639 | -0.061 | -3 | 0.675 |
PIM3 |
0.639 | -0.020 | -3 | 0.676 |
TNIK |
0.639 | -0.041 | 3 | 0.584 |
PLK2 |
0.639 | 0.111 | -3 | 0.692 |
TAO2 |
0.639 | -0.097 | 2 | 0.829 |
TAO3 |
0.639 | -0.039 | 1 | 0.630 |
ZAK |
0.638 | -0.081 | 1 | 0.616 |
LKB1 |
0.637 | -0.072 | -3 | 0.778 |
MARK1 |
0.637 | 0.003 | 4 | 0.624 |
CHAK2 |
0.637 | -0.044 | -1 | 0.670 |
HGK |
0.636 | -0.080 | 3 | 0.590 |
IRAK4 |
0.636 | -0.066 | 1 | 0.671 |
MARK3 |
0.636 | 0.019 | 4 | 0.617 |
CDKL1 |
0.636 | -0.086 | -3 | 0.635 |
NIM1 |
0.636 | -0.040 | 3 | 0.619 |
MINK |
0.636 | -0.103 | 1 | 0.626 |
OSR1 |
0.635 | 0.015 | 2 | 0.782 |
PIM1 |
0.635 | -0.006 | -3 | 0.599 |
NUAK2 |
0.635 | -0.057 | -3 | 0.667 |
JNK3 |
0.635 | -0.021 | 1 | 0.385 |
LRRK2 |
0.634 | -0.140 | 2 | 0.837 |
MTOR |
0.634 | -0.135 | 1 | 0.585 |
IRE1 |
0.634 | -0.042 | 1 | 0.648 |
RSK2 |
0.634 | -0.016 | -3 | 0.601 |
STLK3 |
0.634 | -0.036 | 1 | 0.622 |
ERK5 |
0.634 | -0.096 | 1 | 0.470 |
MST4 |
0.633 | -0.070 | 2 | 0.823 |
CAMK2B |
0.633 | 0.030 | 2 | 0.781 |
MASTL |
0.633 | -0.224 | -2 | 0.607 |
GCK |
0.633 | -0.089 | 1 | 0.608 |
PAK1 |
0.633 | -0.018 | -2 | 0.537 |
RIPK1 |
0.633 | -0.187 | 1 | 0.650 |
JNK2 |
0.632 | -0.026 | 1 | 0.356 |
CHK1 |
0.632 | -0.083 | -3 | 0.679 |
CK2A2 |
0.632 | 0.160 | 1 | 0.424 |
WNK4 |
0.632 | -0.124 | -2 | 0.570 |
SMMLCK |
0.632 | -0.088 | -3 | 0.651 |
PAK2 |
0.632 | -0.046 | -2 | 0.531 |
QSK |
0.632 | -0.016 | 4 | 0.620 |
MELK |
0.631 | -0.074 | -3 | 0.642 |
AMPKA2 |
0.630 | -0.064 | -3 | 0.653 |
PAK3 |
0.630 | -0.055 | -2 | 0.546 |
CHAK1 |
0.630 | -0.073 | 2 | 0.745 |
QIK |
0.630 | -0.081 | -3 | 0.692 |
MYO3A |
0.630 | -0.050 | 1 | 0.652 |
LOK |
0.630 | -0.075 | -2 | 0.589 |
P90RSK |
0.630 | -0.045 | -3 | 0.612 |
P70S6KB |
0.630 | -0.059 | -3 | 0.626 |
MST3 |
0.630 | -0.105 | 2 | 0.814 |
GRK2 |
0.630 | -0.032 | -2 | 0.535 |
DAPK3 |
0.630 | -0.045 | -3 | 0.627 |
CAMK2D |
0.629 | -0.091 | -3 | 0.702 |
PDK1 |
0.629 | -0.150 | 1 | 0.594 |
SIK |
0.629 | -0.024 | -3 | 0.593 |
MYO3B |
0.628 | -0.043 | 2 | 0.799 |
ASK1 |
0.628 | -0.150 | 1 | 0.593 |
DRAK1 |
0.628 | -0.080 | 1 | 0.553 |
YSK1 |
0.628 | -0.112 | 2 | 0.791 |
IRAK1 |
0.627 | -0.154 | -1 | 0.689 |
TTBK1 |
0.627 | -0.034 | 2 | 0.652 |
NUAK1 |
0.627 | -0.041 | -3 | 0.618 |
MAP3K15 |
0.627 | -0.189 | 1 | 0.599 |
LATS2 |
0.627 | -0.037 | -5 | 0.577 |
BCKDK |
0.626 | -0.117 | -1 | 0.632 |
PKN2 |
0.626 | -0.112 | -3 | 0.668 |
NDR1 |
0.626 | -0.064 | -3 | 0.678 |
PINK1 |
0.626 | -0.100 | 1 | 0.580 |
MYLK4 |
0.626 | -0.063 | -2 | 0.551 |
MAPKAPK3 |
0.626 | -0.082 | -3 | 0.607 |
NEK11 |
0.625 | -0.204 | 1 | 0.603 |
RSK3 |
0.625 | -0.053 | -3 | 0.592 |
ICK |
0.625 | -0.128 | -3 | 0.680 |
SSTK |
0.625 | -0.050 | 4 | 0.599 |
BIKE |
0.625 | -0.065 | 1 | 0.455 |
AURB |
0.624 | -0.028 | -2 | 0.472 |
PRKD1 |
0.624 | -0.078 | -3 | 0.676 |
KHS1 |
0.624 | -0.109 | 1 | 0.617 |
SLK |
0.623 | -0.052 | -2 | 0.550 |
NDR2 |
0.623 | -0.049 | -3 | 0.700 |
PKCH |
0.623 | -0.053 | 2 | 0.731 |
P38A |
0.623 | -0.080 | 1 | 0.397 |
MEKK6 |
0.622 | -0.207 | 1 | 0.592 |
PASK |
0.622 | -0.082 | -3 | 0.702 |
CAMK4 |
0.622 | -0.137 | -3 | 0.659 |
CK2A1 |
0.622 | 0.129 | 1 | 0.411 |
PKCA |
0.622 | -0.048 | 2 | 0.726 |
P38B |
0.622 | -0.058 | 1 | 0.342 |
KHS2 |
0.621 | -0.084 | 1 | 0.622 |
ERK2 |
0.621 | -0.075 | 1 | 0.398 |
PIM2 |
0.621 | -0.049 | -3 | 0.565 |
ROCK2 |
0.621 | -0.045 | -3 | 0.613 |
PKCB |
0.621 | -0.022 | 2 | 0.726 |
DCAMKL2 |
0.621 | -0.082 | -3 | 0.637 |
MSK2 |
0.620 | -0.065 | -3 | 0.566 |
DCAMKL1 |
0.620 | -0.089 | -3 | 0.610 |
PKACG |
0.620 | -0.066 | -2 | 0.519 |
SGK3 |
0.620 | -0.065 | -3 | 0.578 |
PAK6 |
0.620 | -0.021 | -2 | 0.513 |
PKCG |
0.620 | -0.048 | 2 | 0.738 |
PKCZ |
0.620 | -0.059 | 2 | 0.765 |
DMPK1 |
0.620 | -0.038 | -3 | 0.568 |
HPK1 |
0.619 | -0.149 | 1 | 0.603 |
MNK2 |
0.619 | -0.066 | -2 | 0.567 |
CDK8 |
0.619 | -0.065 | 1 | 0.402 |
P38G |
0.619 | -0.043 | 1 | 0.295 |
BUB1 |
0.619 | -0.003 | -5 | 0.637 |
CAMK2A |
0.619 | -0.029 | 2 | 0.802 |
MAPKAPK2 |
0.619 | -0.025 | -3 | 0.549 |
AURA |
0.618 | -0.021 | -2 | 0.470 |
SRPK1 |
0.618 | -0.028 | -3 | 0.571 |
RSK4 |
0.618 | -0.018 | -3 | 0.573 |
NEK3 |
0.618 | -0.164 | 1 | 0.591 |
SRPK3 |
0.618 | -0.015 | -3 | 0.543 |
MRCKA |
0.617 | -0.039 | -3 | 0.579 |
P38D |
0.617 | -0.034 | 1 | 0.324 |
CAMK1G |
0.617 | -0.068 | -3 | 0.586 |
MPSK1 |
0.617 | -0.141 | 1 | 0.535 |
PRKD3 |
0.616 | -0.089 | -3 | 0.559 |
MSK1 |
0.616 | -0.054 | -3 | 0.564 |
PRKD2 |
0.616 | -0.073 | -3 | 0.601 |
PKG2 |
0.615 | -0.054 | -2 | 0.473 |
DAPK1 |
0.615 | -0.079 | -3 | 0.606 |
GSK3A |
0.615 | -0.033 | 4 | 0.198 |
GRK3 |
0.615 | -0.018 | -2 | 0.494 |
HASPIN |
0.615 | 0.029 | -1 | 0.580 |
TAO1 |
0.614 | -0.116 | 1 | 0.586 |
CAMK1D |
0.614 | -0.066 | -3 | 0.509 |
CDK2 |
0.614 | -0.079 | 1 | 0.463 |
CDKL5 |
0.614 | -0.119 | -3 | 0.628 |
PKCT |
0.614 | -0.069 | 2 | 0.729 |
SRPK2 |
0.613 | -0.006 | -3 | 0.492 |
CDK5 |
0.613 | -0.073 | 1 | 0.417 |
RIPK2 |
0.613 | -0.181 | 1 | 0.594 |
JNK1 |
0.613 | -0.039 | 1 | 0.353 |
CLK4 |
0.613 | -0.067 | -3 | 0.587 |
MNK1 |
0.612 | -0.071 | -2 | 0.571 |
MRCKB |
0.612 | -0.058 | -3 | 0.555 |
AURC |
0.612 | -0.029 | -2 | 0.465 |
GSK3B |
0.612 | -0.082 | 4 | 0.181 |
CDK1 |
0.612 | -0.053 | 1 | 0.367 |
PBK |
0.611 | -0.131 | 1 | 0.495 |
STK33 |
0.611 | -0.080 | 2 | 0.643 |
AAK1 |
0.611 | -0.049 | 1 | 0.357 |
ERK1 |
0.610 | -0.077 | 1 | 0.331 |
BRSK1 |
0.610 | -0.067 | -3 | 0.622 |
PKACB |
0.610 | -0.024 | -2 | 0.489 |
ROCK1 |
0.610 | -0.059 | -3 | 0.572 |
SNRK |
0.609 | -0.160 | 2 | 0.692 |
DYRK2 |
0.608 | -0.092 | 1 | 0.410 |
BRSK2 |
0.608 | -0.102 | -3 | 0.663 |
KIS |
0.608 | -0.019 | 1 | 0.425 |
HIPK4 |
0.608 | -0.126 | 1 | 0.530 |
MAPKAPK5 |
0.607 | -0.129 | -3 | 0.547 |
DYRK1B |
0.606 | -0.058 | 1 | 0.378 |
CLK1 |
0.606 | -0.073 | -3 | 0.558 |
DYRK1A |
0.606 | -0.096 | 1 | 0.480 |
CDK17 |
0.606 | -0.076 | 1 | 0.313 |
CDK13 |
0.606 | -0.093 | 1 | 0.381 |
AKT2 |
0.605 | -0.080 | -3 | 0.498 |
AKT1 |
0.605 | -0.069 | -3 | 0.517 |
PHKG1 |
0.605 | -0.135 | -3 | 0.672 |
CDK16 |
0.605 | -0.049 | 1 | 0.329 |
PKCI |
0.605 | -0.085 | 2 | 0.745 |
CDK7 |
0.604 | -0.114 | 1 | 0.397 |
P70S6K |
0.604 | -0.097 | -3 | 0.526 |
PAK5 |
0.604 | -0.048 | -2 | 0.458 |
PHKG2 |
0.603 | -0.121 | -3 | 0.625 |
CDK19 |
0.603 | -0.085 | 1 | 0.368 |
ERK7 |
0.603 | -0.038 | 2 | 0.535 |
HIPK1 |
0.603 | -0.101 | 1 | 0.432 |
PKACA |
0.602 | -0.039 | -2 | 0.453 |
CDK18 |
0.602 | -0.080 | 1 | 0.347 |
CRIK |
0.601 | -0.076 | -3 | 0.517 |
CDK12 |
0.600 | -0.094 | 1 | 0.361 |
SGK1 |
0.600 | -0.054 | -3 | 0.412 |
CDK3 |
0.600 | -0.054 | 1 | 0.315 |
HIPK3 |
0.600 | -0.126 | 1 | 0.426 |
PAK4 |
0.600 | -0.043 | -2 | 0.469 |
CAMK1A |
0.600 | -0.084 | -3 | 0.454 |
CDK14 |
0.598 | -0.106 | 1 | 0.393 |
CHK2 |
0.598 | -0.114 | -3 | 0.437 |
PRKX |
0.598 | -0.004 | -3 | 0.493 |
PKCE |
0.598 | -0.071 | 2 | 0.729 |
CLK2 |
0.597 | -0.021 | -3 | 0.564 |
CDK9 |
0.596 | -0.120 | 1 | 0.392 |
CDK6 |
0.595 | -0.099 | 1 | 0.367 |
DYRK3 |
0.595 | -0.095 | 1 | 0.435 |
DYRK4 |
0.595 | -0.075 | 1 | 0.342 |
CK1D |
0.593 | -0.069 | -3 | 0.425 |
CDK4 |
0.592 | -0.108 | 1 | 0.361 |
PKN1 |
0.590 | -0.121 | -3 | 0.543 |
CK1A2 |
0.590 | -0.072 | -3 | 0.411 |
HIPK2 |
0.588 | -0.088 | 1 | 0.326 |
CK1E |
0.588 | -0.081 | -3 | 0.466 |
CK1G1 |
0.587 | -0.055 | -3 | 0.469 |
AKT3 |
0.583 | -0.077 | -3 | 0.430 |
PKG1 |
0.582 | -0.083 | -2 | 0.419 |
YANK3 |
0.582 | -0.058 | 2 | 0.421 |
MAK |
0.581 | -0.107 | -2 | 0.427 |
SBK |
0.579 | -0.110 | -3 | 0.376 |
MOK |
0.579 | -0.134 | 1 | 0.412 |
CDK10 |
0.578 | -0.110 | 1 | 0.374 |
CK1G3 |
0.565 | -0.048 | -3 | 0.300 |
YANK2 |
0.565 | -0.074 | 2 | 0.442 |
CK1A |
0.540 | -0.095 | -3 | 0.346 |
CK1G2 |
0.532 | -0.091 | -3 | 0.391 |