Motif 1032 (n=220)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0A0B4J203 | None | T258 | ochoa | receptor protein-tyrosine kinase (EC 2.7.10.1) | None |
| A1L390 | PLEKHG3 | T782 | ochoa | Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3) | Plays a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. {ECO:0000269|PubMed:27555588}. |
| A6NDB9 | PALM3 | T301 | ochoa | Paralemmin-3 | ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. {ECO:0000269|PubMed:21187075}. |
| A6NKT7 | RGPD3 | T979 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| E7EWF7 | None | T65 | ochoa | Uncharacterized protein | None |
| O00629 | KPNA4 | T71 | ochoa | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Mediates nuclear import of AARS1, MRTFA and RANBP3 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:38512451). {ECO:0000269|PubMed:10567565, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:28760339, ECO:0000269|PubMed:29042532, ECO:0000269|PubMed:38512451}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}. |
| O14545 | TRAFD1 | T469 | ochoa | TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:16221674}. |
| O14715 | RGPD8 | T978 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14777 | NDC80 | T61 | ochoa | Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC) | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205). {ECO:0000269|PubMed:12351790, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:16732327, ECO:0000269|PubMed:23085020, ECO:0000269|PubMed:23891108, ECO:0000269|PubMed:25743205, ECO:0000269|PubMed:30409912, ECO:0000269|PubMed:9315664}. |
| O14874 | BCKDK | T32 | ochoa | Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4) | Serine/threonine-protein kinase component of macronutrients metabolism. Forms a functional kinase and phosphatase pair with PPM1K, serving as a metabolic regulatory node that coordinates branched-chain amino acids (BCAAs) with glucose and lipid metabolism via two distinct phosphoprotein targets: mitochondrial BCKDHA subunit of the branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex and cytosolic ACLY, a lipogenic enzyme of Krebs cycle (PubMed:24449431, PubMed:29779826, PubMed:37558654). Phosphorylates and inactivates mitochondrial BCKDH complex a multisubunit complex consisting of three multimeric components each involved in different steps of BCAA catabolism: E1 composed of BCKDHA and BCKDHB, E2 core composed of DBT monomers, and E3 composed of DLD monomers. Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-337, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH complex (PubMed:29779826, PubMed:37558654). Phosphorylates ACLY on Ser-455 in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (PubMed:29779826). Recognizes phosphosites having SxxE/D canonical motif (PubMed:29779826). {ECO:0000269|PubMed:24449431, ECO:0000269|PubMed:29779826, ECO:0000269|PubMed:37558654}. |
| O14966 | RAB29 | T71 | psp | Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) | The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815, PubMed:38127736). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.typhi) epithelial cell infection (PubMed:22042847). {ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736}. |
| O15211 | RGL2 | T744 | ochoa | Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L) | Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}. |
| O15344 | MID1 | T523 | ochoa | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) | Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination. {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}. |
| O60563 | CCNT1 | T351 | ochoa | Cyclin-T1 (CycT1) (Cyclin-T) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}. |
| O75363 | BCAS1 | T329 | ochoa | Breast carcinoma-amplified sequence 1 (Amplified and overexpressed in breast cancer) (Novel amplified in breast cancer 1) | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| O75376 | NCOR1 | T87 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75376 | NCOR1 | T1670 | ochoa | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| O75496 | GMNN | T59 | ochoa | Geminin | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed:14993212, PubMed:20129055, PubMed:24064211, PubMed:9635433). It is degraded during the mitotic phase of the cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed:14993212, PubMed:24064211, PubMed:9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (PubMed:20129055). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (PubMed:22615398). {ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22615398, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:9635433}. |
| O76080 | ZFAND5 | T71 | ochoa | AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216) | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:14754897}. |
| O94868 | FCHSD2 | T529 | ochoa | F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3) | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. |
| O94967 | WDR47 | T338 | ochoa | WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin) | None |
| O95359 | TACC2 | T2238 | ochoa | Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1) | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269|PubMed:10749935}. |
| O96017 | CHEK2 | T389 | ochoa|psp | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T] (PubMed:37943659). Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). Under oxidative stress, promotes ATG7 ubiquitination by phosphorylating the E3 ubiquitin ligase TRIM32 at 'Ser-55' leading to positive regulation of the autophagosme assembly (PubMed:37943659). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:37943659, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. {ECO:0000269|PubMed:32001251}. |
| P02671 | FGA | T484 | ochoa | Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| P02686 | MBP | T39 | ochoa | Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein) | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| P04049 | RAF1 | T258 | ochoa | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| P04350 | TUBB4A | T219 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P04350 | TUBB4A | T221 | ochoa | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P05783 | KRT18 | T52 | ochoa | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}. |
| P06733 | ENO1 | T26 | ochoa | Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein) | Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:1369209, PubMed:29775581). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| P07437 | TUBB | T219 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P07437 | TUBB | T221 | ochoa | Tubulin beta chain (Tubulin beta-5 chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P08238 | HSP90AB1 | T459 | ochoa | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:16478993, PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription (PubMed:20353823). Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000269|PubMed:16478993, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:19696785, ECO:0000269|PubMed:20353823, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:32272059, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes (PubMed:21949862). Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). {ECO:0000269|PubMed:21949862, ECO:0000305|PubMed:22066472}. |
| P08758 | ANXA5 | T43 | ochoa | Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha) | This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. |
| P0DJD0 | RGPD1 | T963 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T971 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10398 | ARAF | T213 | ochoa | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789). {ECO:0000269|PubMed:22609986, ECO:0000269|PubMed:36402789}.; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269|PubMed:22609986}. |
| P11137 | MAP2 | T1154 | ochoa | Microtubule-associated protein 2 (MAP-2) | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| P11171 | EPB41 | T559 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P12931 | SRC | T183 | ochoa | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors (PubMed:34234773). Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (PubMed:25501895). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:14585963, PubMed:8755529). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances RIGI-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (PubMed:25731159). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function (PubMed:16619028). {ECO:0000250|UniProtKB:P05480, ECO:0000250|UniProtKB:Q9WUD9, ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:12615910, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:16619028, ECO:0000269|PubMed:18586953, ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:19419966, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:21309750, ECO:0000269|PubMed:21411625, ECO:0000269|PubMed:22710723, ECO:0000269|PubMed:25501895, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:34234773, ECO:0000269|PubMed:35927303, ECO:0000269|PubMed:7853507, ECO:0000269|PubMed:8755529, ECO:0000269|PubMed:8759729, ECO:0000305|PubMed:11964124, ECO:0000305|PubMed:8672527, ECO:0000305|PubMed:9442882}.; FUNCTION: [Isoform 1]: Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity. {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 2]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}.; FUNCTION: [Isoform 3]: Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (By similarity). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (By similarity). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (By similarity). Plays a role in neurite elongation (By similarity). {ECO:0000250|UniProtKB:Q9WUD9}. |
| P12956 | XRCC6 | T305 | ochoa | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Required for double-strand break repair and V(D)J recombination (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Also has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Has a role in chromosome translocation (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). It works in the 3'-5' direction (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Binding to DNA may be mediated by XRCC6 (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:11493912, PubMed:12145306, PubMed:20493174, PubMed:2466842, PubMed:7957065, PubMed:8621488, PubMed:9742108). Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123). 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123). The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Negatively regulates apoptosis by interacting with BAX and sequestering it from the mitochondria (PubMed:15023334). Might have deubiquitination activity, acting on BAX (PubMed:18362350). {ECO:0000269|PubMed:11493912, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15023334, ECO:0000269|PubMed:18362350, ECO:0000269|PubMed:20383123, ECO:0000269|PubMed:20493174, ECO:0000269|PubMed:2466842, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:7957065, ECO:0000269|PubMed:8621488, ECO:0000269|PubMed:9742108}. |
| P14859 | POU2F1 | T384 | ochoa | POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. {ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:1684878, ECO:0000269|PubMed:7859290}.; FUNCTION: (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000305|PubMed:12826401}. |
| P15336 | ATF2 | T339 | ochoa | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}. |
| P16144 | ITGB4 | T1464 | ochoa | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P16989 | YBX3 | T317 | ochoa | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}. |
| P17181 | IFNAR1 | T494 | ochoa | Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) | Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461, PubMed:21854986, PubMed:24075985, PubMed:31270247, PubMed:33252644, PubMed:35442418, PubMed:7813427). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:21854986, PubMed:7665574). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (PubMed:21854986, PubMed:32972995, PubMed:7526154, PubMed:7665574, PubMed:7813427). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:19561067, PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427, PubMed:9121453). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:31270247, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33252644, ECO:0000269|PubMed:35442418, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:9121453}. |
| P17661 | DES | T59 | ochoa | Desmin | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Required for nuclear membrane integrity, via anchoring at the cell tip and nuclear envelope, resulting in maintenance of microtubule-derived intracellular mechanical forces (By similarity). Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin (By similarity). {ECO:0000250|UniProtKB:P31001, ECO:0000269|PubMed:24200904, ECO:0000269|PubMed:25394388, ECO:0000269|PubMed:26724190, ECO:0000303|PubMed:25358400}. |
| P21333 | FLNA | T1255 | ochoa | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) | Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}. |
| P22234 | PAICS | T275 | ochoa | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway. {ECO:0000269|PubMed:17224163, ECO:0000269|PubMed:2183217, ECO:0000269|PubMed:31600779}. |
| P23497 | SP100 | T222 | ochoa | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}. |
| P25705 | ATP5F1A | T64 | ochoa | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain (PubMed:37244256). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (Probable). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). {ECO:0000250|UniProtKB:P19483, ECO:0000269|PubMed:30146159, ECO:0000269|PubMed:37244256, ECO:0000305|PubMed:37244256}. |
| P27816 | MAP4 | T927 | ochoa|psp | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P28908 | TNFRSF8 | T428 | ochoa | Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30) | Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). {ECO:0000269|PubMed:8391931, ECO:0000269|PubMed:8999898}. |
| P35408 | PTGER4 | T429 | ochoa | Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| P36897 | TGFBR1 | T186 | psp | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis (PubMed:33914044). The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. {ECO:0000269|PubMed:15761148, ECO:0000269|PubMed:16754747, ECO:0000269|PubMed:18758450, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:7774578, ECO:0000269|PubMed:8752209, ECO:0000269|PubMed:8980228, ECO:0000269|PubMed:9346908}. |
| P36915 | GNL1 | T50 | ochoa | Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1) | Possible regulatory or functional link with the histocompatibility cluster. |
| P38936 | CDKN1A | T80 | psp | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Negatively regulates the CDK4- and CDK6-driven phosphorylation of RB1 in keratinocytes, thereby resulting in the release of E2F1 and subsequent transcription of E2F1-driven G1/S phase promoting genes (By similarity). {ECO:0000250|UniProtKB:P39689, ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}. |
| P45974 | USP5 | T148 | ochoa | Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) | Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity). {ECO:0000250|UniProtKB:P56399, ECO:0000269|PubMed:19098288, ECO:0000269|PubMed:26912724, ECO:0000269|PubMed:29567855, ECO:0000269|PubMed:37208329, ECO:0000269|PubMed:37534934, ECO:0000269|PubMed:39032648, ECO:0000269|PubMed:39761299, ECO:0000269|PubMed:39900921}. |
| P48960 | ADGRE5 | T817 | ochoa | Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta] | Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. {ECO:0000250|UniProtKB:Q9Z0M6}. |
| P49327 | FASN | T1726 | ochoa | Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. {ECO:0000269|PubMed:16215233, ECO:0000269|PubMed:16969344, ECO:0000269|PubMed:26851298, ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:8962082, ECO:0000269|PubMed:9356448}.; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. {ECO:0000269|PubMed:34320401}. |
| P49792 | RANBP2 | T1513 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P49792 | RANBP2 | T1954 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50238 | CRIP1 | T39 | ochoa | Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP) | Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. |
| P51825 | AFF1 | T619 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52701 | MSH6 | T86 | ochoa | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. {ECO:0000269|PubMed:10078208, ECO:0000269|PubMed:10660545, ECO:0000269|PubMed:15064730, ECO:0000269|PubMed:21120944, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:9564049, ECO:0000269|PubMed:9822679, ECO:0000269|PubMed:9822680}. |
| P54252 | ATXN3 | T271 | ochoa | Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein) | Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (PubMed:33157014). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:33157014}. |
| P55196 | AFDN | T1198 | ochoa | Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor) | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011). {ECO:0000250|UniProtKB:O35889, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:30463011}. |
| P55197 | MLLT10 | T301 | ochoa | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. |
| P62857 | RPS28 | T38 | ochoa | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | Component of the small ribosomal subunit (PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:25957688). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000269|PubMed:34516797}. |
| P68371 | TUBB4B | T219 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P68371 | TUBB4B | T221 | ochoa | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| P78527 | PRKDC | T2671 | ochoa|psp | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460) | Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250|UniProtKB:P97313, ECO:0000269|PubMed:10026262, ECO:0000269|PubMed:10467406, ECO:0000269|PubMed:11889123, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12509254, ECO:0000269|PubMed:12649176, ECO:0000269|PubMed:14599745, ECO:0000269|PubMed:14612514, ECO:0000269|PubMed:14627815, ECO:0000269|PubMed:14704337, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:15177042, ECO:0000269|PubMed:15262962, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:1597196, ECO:0000269|PubMed:16046194, ECO:0000269|PubMed:16397295, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:2247066, ECO:0000269|PubMed:2507541, ECO:0000269|PubMed:26237645, ECO:0000269|PubMed:26666690, ECO:0000269|PubMed:28712728, ECO:0000269|PubMed:29478807, ECO:0000269|PubMed:30247612, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:33273464, ECO:0000269|PubMed:33854234, ECO:0000269|PubMed:34352203, ECO:0000269|PubMed:35460603, ECO:0000269|PubMed:8407951, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:9139719, ECO:0000269|PubMed:9362500, ECO:0000269|PubMed:9363941, ECO:0000269|PubMed:9679063}. |
| Q01130 | SRSF2 | T25 | ochoa | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q02880 | TOP2B | T1575 | ochoa | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}. |
| Q02952 | AKAP12 | T521 | ochoa | A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen) | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Q03164 | KMT2A | T2812 | ochoa | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. |
| Q12802 | AKAP13 | T849 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12802 | AKAP13 | T863 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12888 | TP53BP1 | T1672 | ochoa | TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136, ECO:0000269|PubMed:31135337, ECO:0000269|PubMed:37696958}. |
| Q13136 | PPFIA1 | T548 | ochoa | Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Q13191 | CBLB | T885 | ochoa | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}. |
| Q13237 | PRKG2 | T109 | ochoa | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. |
| Q13263 | TRIM28 | T611 | ochoa | Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28) | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000250|UniProtKB:Q62318, ECO:0000269|PubMed:10347202, ECO:0000269|PubMed:11959841, ECO:0000269|PubMed:15882967, ECO:0000269|PubMed:16107876, ECO:0000269|PubMed:16862143, ECO:0000269|PubMed:17079232, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:17942393, ECO:0000269|PubMed:18060868, ECO:0000269|PubMed:18082607, ECO:0000269|PubMed:20424263, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:21940674, ECO:0000269|PubMed:23543754, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24623306, ECO:0000269|PubMed:27029610, ECO:0000269|PubMed:8769649, ECO:0000269|PubMed:9016654}.; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. {ECO:0000269|PubMed:24741090}. |
| Q13393 | PLD1 | T504 | ochoa | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) | Function as phospholipase selective for phosphatidylcholine (PubMed:25936805, PubMed:8530346, PubMed:9582313). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250|UniProtKB:Q9Z280, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:8530346, ECO:0000269|PubMed:9582313}. |
| Q13885 | TUBB2A | T219 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q13885 | TUBB2A | T221 | ochoa | Tubulin beta-2A chain (Tubulin beta class IIa) | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q13905 | RAPGEF1 | T310 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q13950 | RUNX2 | T346 | ochoa | Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28703881, PubMed:28738062). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:28505335, ECO:0000269|PubMed:28703881, ECO:0000269|PubMed:28738062}. |
| Q14004 | CDK13 | T1482 | ochoa | Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) | Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}. |
| Q14156 | EFR3A | T414 | ochoa | Protein EFR3 homolog A (Protein EFR3-like) | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000305}. |
| Q14160 | SCRIB | T1558 | ochoa | Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) | Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q80U72, ECO:0000269|PubMed:15182672, ECO:0000269|PubMed:16344308, ECO:0000269|PubMed:16965391, ECO:0000269|PubMed:18641685, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:27380321}. |
| Q14203 | DCTN1 | T1152 | ochoa | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule (PubMed:25185702). Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon (PubMed:23874158). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole (PubMed:23386061). Plays a role in primary cilia formation (PubMed:25774020). {ECO:0000250|UniProtKB:A0A287B8J2, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23386061, ECO:0000269|PubMed:23874158, ECO:0000269|PubMed:25185702, ECO:0000269|PubMed:25774020}. |
| Q14207 | NPAT | T1347 | ochoa | Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220) | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Q14315 | FLNC | T1250 | ochoa | Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (PubMed:34405687). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity). {ECO:0000250|UniProtKB:Q8VHX6, ECO:0000269|PubMed:34405687}. |
| Q14432 | PDE3A | T311 | ochoa | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). {ECO:0000269|PubMed:1315035, ECO:0000269|PubMed:25961942, ECO:0000269|PubMed:27975297, ECO:0000269|PubMed:31420216, ECO:0000269|PubMed:34707099, ECO:0000269|PubMed:8155697, ECO:0000269|PubMed:8695850}. |
| Q14CZ0 | HAPSTR1 | T172 | ochoa | HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein) | Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365). {ECO:0000269|PubMed:33660365, ECO:0000269|PubMed:35776542}. |
| Q27J81 | INF2 | T1135 | ochoa | Inverted formin-2 (HBEBP2-binding protein C) | Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}. |
| Q3MIW9 | MUCL3 | T120 | ochoa | Mucin-like protein 3 (Diffuse panbronchiolitis critical region protein 1) | May modulate NF-kappaB signaling and play a role in cell growth. {ECO:0000269|PubMed:29242154}. |
| Q3V6T2 | CCDC88A | T1560 | ochoa | Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) | Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:16139227, PubMed:19211784, PubMed:20462955, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}. |
| Q53EL6 | PDCD4 | T93 | ochoa | Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:16357133, ECO:0000269|PubMed:16449643, ECO:0000269|PubMed:17053147, ECO:0000269|PubMed:18296639, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}. |
| Q53T59 | HS1BP3 | T146 | ochoa | HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) | May be a modulator of IL-2 signaling. {ECO:0000250}. |
| Q5SW79 | CEP170 | T1240 | ochoa | Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein) | Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}. |
| Q5T0W9 | FAM83B | T919 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5T1M5 | FKBP15 | T355 | ochoa | FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL) | May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Q5T3F8 | TMEM63B | T110 | ochoa | Mechanosensitive cation channel TMEM63B (Transmembrane protein 63B) (hTMEM63B) | Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:37543036, PubMed:38127458). Osmosensitive cation channel preferentially activated by hypotonic stress (PubMed:37543036, PubMed:38127458). Also acts as a phospholipid scramblase in response to changes in membrane structure: upon changes in membrane curvature and thickness, alters its conformation and translocates phospholipids, such as phosphatidylcholine and sphingomyelin, thereby controlling plasma membrane lipid distribution (PubMed:39217145, PubMed:39424995, PubMed:39716028). Forms a heterodimer with SLC19A2, which mediates phospholipid scramblase activity following Ca(2+) stimulation (By similarity). Expressed in excitatory neurons of the subfornical organ and functions as a thirst receptor that mediates neuronal response to hyperosmolality to drive thirst and drinking behavior (By similarity). Facilitates intestinal motility by promoting proliferation of intestinal stem cells (By similarity). Essential for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Acts as an osmosensor in cochlear outer hair cells (OHCs) where it mediates calcium influx and regulatory volume decrease response (By similarity). Required for the maintenance of OHC morphology, OHC survival and normal hearing (By similarity). {ECO:0000250|UniProtKB:Q3TWI9, ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458, ECO:0000269|PubMed:39217145, ECO:0000269|PubMed:39424995, ECO:0000269|PubMed:39716028}. |
| Q5THJ4 | VPS13D | T2092 | ochoa | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555, PubMed:29604224). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:29307555, ECO:0000269|PubMed:29604224}. |
| Q5VT06 | CEP350 | T1273 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VT52 | RPRD2 | T715 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | T743 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VT52 | RPRD2 | T1133 | ochoa | Regulation of nuclear pre-mRNA domain-containing protein 2 | None |
| Q5VZ89 | DENND4C | T1552 | ochoa | DENN domain-containing protein 4C | Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. {ECO:0000269|PubMed:20937701}. |
| Q63ZY3 | KANK2 | T82 | ochoa | KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein) | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q8BX02, ECO:0000269|PubMed:17476305, ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:22371500, ECO:0000269|PubMed:24671081, ECO:0000269|PubMed:25961457}. |
| Q6IA86 | ELP2 | T121 | ochoa | Elongator complex protein 2 (ELP2) (SHINC-2) (STAT3-interacting protein 1) (StIP1) | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). {ECO:0000303|PubMed:29332244}. |
| Q6J9G0 | STYK1 | T90 | ochoa | Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1) | Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}. |
| Q6P435 | None | T110 | ochoa | Putative uncharacterized SMG1-like protein | None |
| Q6UN15 | FIP1L1 | T258 | ochoa | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}. |
| Q6UXY8 | TMC5 | T268 | ochoa | Transmembrane channel-like protein 5 | Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable). {ECO:0000305}. |
| Q76N89 | HECW1 | T67 | ochoa | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}. |
| Q7Z2W4 | ZC3HAV1 | T326 | ochoa | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Q7Z3J3 | RGPD4 | T979 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z401 | DENND4A | T921 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z434 | MAVS | T252 | ochoa | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) | Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325). {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20451243, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:27992402, ECO:0000269|PubMed:33110251, ECO:0000269|PubMed:33139700, ECO:0000269|PubMed:37582970}. |
| Q7Z460 | CLASP1 | T796 | ochoa | CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}. |
| Q7Z628 | NET1 | T35 | ochoa | Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8) | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}. |
| Q7Z6J6 | FRMD5 | T395 | ochoa | FERM domain-containing protein 5 | May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). |
| Q86UE4 | MTDH | T495 | ochoa | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}. |
| Q86V48 | LUZP1 | T819 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86V48 | LUZP1 | T821 | ochoa | Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin) | F-actin cross-linking protein (PubMed:30990684). Stabilizes actin and acts as a negative regulator of primary cilium formation (PubMed:32496561). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (PubMed:38832964). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (PubMed:38009294). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q8R4U7, ECO:0000269|PubMed:30990684, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:38009294, ECO:0000269|PubMed:38832964}. |
| Q86X29 | LSR | T435 | ochoa | Lipolysis-stimulated lipoprotein receptor (Angulin-1) | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity). {ECO:0000250|UniProtKB:Q99KG5, ECO:0000250|UniProtKB:Q9WU74}. |
| Q8N1F7 | NUP93 | T51 | ochoa | Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93) | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. |
| Q8N2F6 | ARMC10 | T53 | ochoa | Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein) | May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}. |
| Q8NF91 | SYNE1 | T8687 | ochoa | Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) | Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenesis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q6ZWR6, ECO:0000269|PubMed:11792814, ECO:0000269|PubMed:18396275}. |
| Q8NHH9 | ATL2 | T23 | ochoa | Atlastin-2 (ATL-2) (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) | Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:18270207, PubMed:19665976, PubMed:22065636, PubMed:27619977, PubMed:34817557). Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). {ECO:0000250|UniProtKB:Q8WXF7, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:22065636, ECO:0000269|PubMed:27619977, ECO:0000269|PubMed:34817557}. |
| Q8TB45 | DEPTOR | T315 | ochoa | DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6) | Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269). {ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:25936805, ECO:0000269|PubMed:29382726, ECO:0000269|PubMed:34519268, ECO:0000269|PubMed:34519269}. |
| Q8TF40 | FNIP1 | T295 | ochoa | Folliculin-interacting protein 1 | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580). {ECO:0000250|UniProtKB:Q68FD7, ECO:0000250|UniProtKB:Q9P278, ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25126726, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:30699359, ECO:0000269|PubMed:32905580, ECO:0000269|PubMed:37079666}. |
| Q8TF72 | SHROOM3 | T1099 | ochoa | Protein Shroom3 (Shroom-related protein) (hShrmL) | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000250|UniProtKB:Q9QXN0}. |
| Q8WUB8 | PHF10 | T318 | ochoa | PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) | Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}. |
| Q8WUM0 | NUP133 | T474 | ochoa | Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) | Involved in poly(A)+ RNA transport. Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:11684705, ECO:0000269|PubMed:30179222}. |
| Q8WWM7 | ATXN2L | T679 | ochoa | Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein) | Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}. |
| Q92614 | MYO18A | T727 | ochoa | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}. |
| Q92619 | ARHGAP45 | T66 | ochoa | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] | Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. {ECO:0000269|PubMed:24086303}.; FUNCTION: Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. {ECO:0000269|PubMed:12601144, ECO:0000269|PubMed:8260714, ECO:0000269|PubMed:8532022, ECO:0000269|PubMed:9798702}. |
| Q92844 | TANK | T224 | ochoa | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}. |
| Q92851 | CASP10 | T268 | ochoa | Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445, ECO:0000269|PubMed:16916640}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}. |
| Q92917 | GPKOW | T26 | ochoa | G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54) | RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:25296192, ECO:0000305|PubMed:33509932}. |
| Q969V6 | MRTFA | T153 | ochoa | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. {ECO:0000250|UniProtKB:Q8K4J6, ECO:0000269|PubMed:26224645}. |
| Q96BD0 | SLCO4A1 | T54 | ochoa | Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) | Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000269|PubMed:10873595, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:30343886, ECO:0000305}. |
| Q96BY6 | DOCK10 | T1231 | ochoa | Dedicator of cytokinesis protein 10 (Zizimin-3) | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}. |
| Q96C57 | CUSTOS | T57 | ochoa | Protein CUSTOS | Plays a role in the regulation of Wnt signaling pathway during early development. {ECO:0000250|UniProtKB:A9C3N6}. |
| Q96CC6 | RHBDF1 | T75 | ochoa | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18524845, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}. |
| Q96HC4 | PDLIM5 | T216 | ochoa | PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation. {ECO:0000250|UniProtKB:Q62920}. |
| Q96N67 | DOCK7 | T451 | ochoa | Dedicator of cytokinesis protein 7 | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419, ECO:0000269|PubMed:29467281}. |
| Q96NE9 | FRMD6 | T428 | ochoa | FERM domain-containing protein 6 (Willin) | None |
| Q96Q15 | SMG1 | T114 | ochoa | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269, ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:16452507}. |
| Q96R06 | SPAG5 | T352 | ochoa | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457). {ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074, ECO:0000305|PubMed:11724960}. |
| Q96RL1 | UIMC1 | T253 | ochoa | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.38). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:19015238, ECO:0000269|PubMed:19202061, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19328070, ECO:0000269|PubMed:24627472, ECO:0000269|Ref.38}. |
| Q96RR4 | CAMKK2 | T85 | ochoa|psp | Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:9662074}. |
| Q96RU2 | USP28 | T130 | ochoa | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306). {ECO:0000269|PubMed:16901786, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:24623306}. |
| Q96T17 | MAP7D2 | T230 | ochoa | MAP7 domain-containing protein 2 | Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule (By similarity). Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity). {ECO:0000250|UniProtKB:A2AG50, ECO:0000250|UniProtKB:D4A4L4}. |
| Q99490 | AGAP2 | T647 | ochoa | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}. |
| Q99569 | PKP4 | T456 | ochoa | Plakophilin-4 (p0071) | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269|PubMed:17115030}. |
| Q99650 | OSMR | T888 | ochoa | Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) | Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}. |
| Q99661 | KIF2C | T457 | ochoa | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108). {ECO:0000269|PubMed:19060894, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. |
| Q99666 | RGPD5 | T978 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99683 | MAP3K5 | T976 | ochoa | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Q99700 | ATXN2 | T529 | ochoa | Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) | Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. {ECO:0000269|PubMed:18602463}. |
| Q99714 | HSD17B10 | T66 | ochoa | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:10600649, PubMed:12917011, PubMed:18996107, PubMed:19706438, PubMed:20077426, PubMed:25925575, PubMed:26950678, PubMed:28888424, PubMed:9553139). Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA (PubMed:10600649, PubMed:12917011, PubMed:25925575, PubMed:26950678, PubMed:9553139). Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway (PubMed:18996107, PubMed:19706438, PubMed:20077426). Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids (PubMed:10600649, PubMed:12917011). Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel (PubMed:19706438, PubMed:28888424). Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis (PubMed:26338420). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). {ECO:0000269|PubMed:10600649, ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18996107, ECO:0000269|PubMed:19706438, ECO:0000269|PubMed:20077426, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26338420, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:9553139}.; FUNCTION: In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424). Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24549042, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:29040705}. |
| Q9BQ39 | DDX50 | T672 | ochoa | ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) | ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908). {ECO:0000269|PubMed:12027455, ECO:0000269|PubMed:28181036, ECO:0000269|PubMed:35215908}. |
| Q9BR39 | JPH2 | T161 | ochoa | Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)] | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity). {ECO:0000250|UniProtKB:Q9ET78, ECO:0000269|PubMed:20095964}.; FUNCTION: [Junctophilin-2 N-terminal fragment]: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins. {ECO:0000250|UniProtKB:Q9ET78}. |
| Q9BRL6 | SRSF8 | T25 | ochoa | Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B) | Involved in pre-mRNA alternative splicing. {ECO:0000269|PubMed:9671500}. |
| Q9BTA9 | WAC | T93 | ochoa | WW domain-containing adapter protein with coiled-coil | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269|PubMed:21329877, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:26812014}. |
| Q9BTF0 | THUMPD2 | T456 | ochoa | U6 snRNA (guanine-N(2))-methyltransferase THUMPD2 (EC 2.1.1.-) (THUMP domain-containing protein 2) | Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome (PubMed:37283053). This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels (PubMed:37283053). {ECO:0000269|PubMed:37283053}. |
| Q9BTK6 | PAGR1 | T25 | ochoa | PAXIP1-associated glutamate-rich protein 1 (Glutamate-rich coactivator interacting with SRC1) (GAS) (PAXIP1-associated protein 1) (PTIP-associated protein 1) | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (By similarity). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582). {ECO:0000250|UniProtKB:Q99L02, ECO:0000269|PubMed:19039327, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:23161582, ECO:0000305}. |
| Q9BTV7 | CABLES2 | T125 | ochoa | CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2) | Unknown. Probably involved in G1-S cell cycle transition. |
| Q9BV36 | MLPH | T313 | ochoa | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269|PubMed:12062444}. |
| Q9BVA1 | TUBB2B | T219 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BVA1 | TUBB2B | T221 | ochoa | Tubulin beta-2B chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910). {ECO:0000269|PubMed:19465910, ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:26732629, ECO:0000269|PubMed:28013290}. |
| Q9BXF6 | RAB11FIP5 | T563 | ochoa | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269|PubMed:11163216, ECO:0000269|PubMed:20717956}. |
| Q9BXL7 | CARD11 | T880 | ochoa | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) | Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108). {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28628108}. |
| Q9BY89 | KIAA1671 | T1597 | ochoa | Uncharacterized protein KIAA1671 | None |
| Q9C0B5 | ZDHHC5 | T454 | ochoa | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609, PubMed:31649195, PubMed:34293401, PubMed:38092000, PubMed:38530158, PubMed:38599239). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) (PubMed:26334723). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195, PubMed:34293401). Also participates in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane (PubMed:32958780). Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity). Acts as a regulator of inflammatory response by mediating palmitoylation of NLRP3 and GSDMD (PubMed:38092000, PubMed:38530158, PubMed:38599239). Palmitoylates NLRP3 to promote inflammasome assembly and activation (PubMed:38092000). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD), thereby promoting membrane translocation and pore formation of GSDMD (PubMed:38530158, PubMed:38599239). {ECO:0000250|UniProtKB:Q8VDZ4, ECO:0000269|PubMed:21820437, ECO:0000269|PubMed:26334723, ECO:0000269|PubMed:29185452, ECO:0000269|PubMed:31402609, ECO:0000269|PubMed:31649195, ECO:0000269|PubMed:32958780, ECO:0000269|PubMed:34293401, ECO:0000269|PubMed:38092000, ECO:0000269|PubMed:38530158, ECO:0000269|PubMed:38599239}. |
| Q9GZY8 | MFF | T262 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H2Y7 | ZNF106 | T672 | ochoa | Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) | RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism. {ECO:0000250|UniProtKB:O88466}. |
| Q9H4L4 | SENP3 | T142 | psp | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397). {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085, ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224, ECO:0000269|PubMed:22872859, ECO:0000269|PubMed:32832608, ECO:0000269|PubMed:36050397}. |
| Q9H6U6 | BCAS3 | T897 | ochoa | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712). Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Q9H8V3 | ECT2 | T857 | ochoa | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:10579713, ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234, ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035, ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:25068414, ECO:0000269|PubMed:31888991}. |
| Q9H9C1 | VIPAS39 | T104 | ochoa | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}. |
| Q9HDC5 | JPH1 | T161 | ochoa | Junctophilin-1 (JP-1) (Junctophilin type 1) | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Q9NQZ2 | UTP3 | T41 | ochoa | Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog) | Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13, ECO:0000269|PubMed:34516797}. |
| Q9NUQ6 | SPATS2L | T517 | ochoa | SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP) | None |
| Q9NWH9 | SLTM | T961 | ochoa | SAFB-like transcription modulator (Modulator of estrogen-induced transcription) | When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis. {ECO:0000250}. |
| Q9NYL2 | MAP3K20 | T666 | ochoa | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) | Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation (PubMed:10924358, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15350844, PubMed:15737997, PubMed:18331592, PubMed:20559024, PubMed:26999302, PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11042189, PubMed:11836244, PubMed:12220515, PubMed:14521931, PubMed:15172994, PubMed:15737997, PubMed:32289254, PubMed:32610081, PubMed:35857590). Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress (PubMed:15350844, PubMed:21224381, PubMed:27859413). May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2 (PubMed:15342622). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:12220515, ECO:0000269|PubMed:14521931, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:15350844, ECO:0000269|PubMed:15737997, ECO:0000269|PubMed:18331592, ECO:0000269|PubMed:20559024, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26999302, ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation (PubMed:32289254, PubMed:32610081, PubMed:35857590). Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes (PubMed:32289254, PubMed:32610081). Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively (PubMed:32610081). Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death (PubMed:32289254, PubMed:32610081). Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha (PubMed:32610081). Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis (PubMed:35857590). NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20 (PubMed:35857590). Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph) (PubMed:15684425). {ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}.; FUNCTION: [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress (PubMed:32289254, PubMed:32610081, PubMed:35857590). May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha (PubMed:27859413). {ECO:0000269|PubMed:27859413, ECO:0000269|PubMed:32289254, ECO:0000269|PubMed:32610081, ECO:0000269|PubMed:35857590}. |
| Q9NZQ3 | NCKIPSD | T118 | ochoa | NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) | Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}. |
| Q9P0L0 | VAPA | T215 | ochoa | Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33) | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). {ECO:0000269|PubMed:11511104, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:19289470, ECO:0000269|PubMed:25447204, ECO:0000269|PubMed:32344433, ECO:0000269|PubMed:33124732}. |
| Q9P242 | NYAP2 | T153 | ochoa | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}. |
| Q9P244 | LRFN1 | T658 | ochoa | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2) | Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}. |
| Q9P265 | DIP2B | T200 | ochoa | Disco-interacting protein 2 homolog B (DIP2 homolog B) | Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}. |
| Q9UBL3 | ASH2L | T91 | ochoa | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}. |
| Q9UBP0 | SPAST | T242 | ochoa | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex (PubMed:19000169, PubMed:21310966, PubMed:26040712). Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex (PubMed:21310966). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling (PubMed:23897888). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing (PubMed:23897888). Probably plays a role in axon growth and the formation of axonal branches (PubMed:15716377). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20530212, ECO:0000269|PubMed:21310966, ECO:0000269|PubMed:22637577, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:26875866}.; FUNCTION: [Isoform 1]: Involved in lipid metabolism by regulating the size and distribution of lipid droplets. {ECO:0000269|PubMed:25875445}. |
| Q9UJF2 | RASAL2 | T64 | ochoa | Ras GTPase-activating protein nGAP (RAS protein activator-like 2) | Inhibitory regulator of the Ras-cyclic AMP pathway. |
| Q9UKD1 | GMEB2 | T365 | ochoa | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| Q9UKV0 | HDAC9 | T183 | ochoa | Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. {ECO:0000269|PubMed:11535832}.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Q9ULC3 | RAB23 | T196 | ochoa | Ras-related protein Rab-23 (EC 3.6.5.2) | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. {ECO:0000269|PubMed:22365972, ECO:0000269|PubMed:22452336}. |
| Q9ULC8 | ZDHHC8 | T641 | ochoa | Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378) | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (Probable). Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (Probable). Could also play a role in glutamatergic transmission (By similarity). {ECO:0000250|UniProtKB:Q5Y5T5, ECO:0000305|PubMed:19556522, ECO:0000305|PubMed:23034182, ECO:0000305|PubMed:26535572}.; FUNCTION: (Microbial infection) Able to palmitoylate SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. {ECO:0000269|PubMed:34599882}. |
| Q9ULT8 | HECTD1 | T1728 | ochoa | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:33711283). Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion (By similarity). Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure (By similarity). Catalyzes ubiquitination and degradation of ZNF622, an assembly factor for the ribosomal 60S subunit, in hematopoietic cells, thereby promoting hematopoietic stem cell renewal (PubMed:33711283). {ECO:0000250|UniProtKB:Q69ZR2, ECO:0000269|PubMed:33711283}. |
| Q9ULV3 | CIZ1 | T349 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UMZ2 | SYNRG | T931 | ochoa | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}. |
| Q9UPN3 | MACF1 | T4391 | ochoa | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) | [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}. |
| Q9UPT8 | ZC3H4 | T898 | ochoa | Zinc finger CCCH domain-containing protein 4 | RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33767452, PubMed:33913806). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33767452, PubMed:33913806). Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452, PubMed:33913806). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452). {ECO:0000269|PubMed:33767452, ECO:0000269|PubMed:33913806}. |
| Q9Y2L6 | FRMD4B | T918 | ochoa | FERM domain-containing protein 4B (GRP1-binding protein GRSP1) | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. {ECO:0000250|UniProtKB:Q920B0}. |
| Q9Y2X9 | ZNF281 | T637 | ochoa | Zinc finger protein 281 (GC-box-binding zinc finger protein 1) (Transcription factor ZBP-99) (Zinc finger DNA-binding protein 99) | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
| Q9Y446 | PKP3 | T79 | ochoa | Plakophilin-3 | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (PubMed:25208567). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (PubMed:25208567). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (PubMed:25225333). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (PubMed:34058472). {ECO:0000250|UniProtKB:Q9QY23, ECO:0000269|PubMed:20859650, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:25208567, ECO:0000269|PubMed:25225333, ECO:0000269|PubMed:34058472}. |
| Q9Y5K6 | CD2AP | T468 | ochoa | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8, ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567, ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}. |
| Q9Y6I3 | EPN1 | T416 | ochoa | Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1) | Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078). {ECO:0000250|UniProtKB:O88339, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:10557078}. |
| P50991 | CCT4 | T50 | Sugiyama | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P07900 | HSP90AA1 | T467 | Sugiyama | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:26991466, PubMed:27295069). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues (PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}. |
| P14854 | COX6B1 | T67 | Sugiyama | Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:Q01519}. |
| P50416 | CPT1A | T370 | Sugiyama | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) (Succinyltransferase CPT1A) (EC 2.3.1.-) | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:11350182, ECO:0000269|PubMed:14517221, ECO:0000269|PubMed:16651524, ECO:0000269|PubMed:29425493, ECO:0000269|PubMed:38016475, ECO:0000269|PubMed:9691089}. |
| Q7Z2W4 | ZC3HAV1 | T363 | Sugiyama | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435, ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| O15067 | PFAS | T539 | Sugiyama | Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase) | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO:0000305|PubMed:10548741}. |
| Q8IWI9 | MGA | T862 | Sugiyama | MAX gene-associated protein (MAX dimerization protein 5) | Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity). {ECO:0000250|UniProtKB:A2AWL7}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.000016 | 4.799 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.000020 | 4.710 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.000013 | 4.891 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.000021 | 4.678 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.000011 | 4.963 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.000014 | 4.840 |
| R-HSA-68877 | Mitotic Prometaphase | 0.000018 | 4.741 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.000028 | 4.560 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.000026 | 4.587 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.000036 | 4.441 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.000054 | 4.265 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.000055 | 4.257 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.000077 | 4.114 |
| R-HSA-9646399 | Aggrephagy | 0.000077 | 4.115 |
| R-HSA-1640170 | Cell Cycle | 0.000077 | 4.115 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.000090 | 4.046 |
| R-HSA-69560 | Transcriptional activation of p53 responsive genes | 0.000104 | 3.985 |
| R-HSA-69895 | Transcriptional activation of cell cycle inhibitor p21 | 0.000104 | 3.985 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.000099 | 4.006 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.000096 | 4.017 |
| R-HSA-913531 | Interferon Signaling | 0.000110 | 3.957 |
| R-HSA-437239 | Recycling pathway of L1 | 0.000179 | 3.748 |
| R-HSA-68882 | Mitotic Anaphase | 0.000216 | 3.665 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.000216 | 3.665 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.000225 | 3.648 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.000236 | 3.626 |
| R-HSA-69275 | G2/M Transition | 0.000252 | 3.599 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.000273 | 3.564 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.000295 | 3.531 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.000367 | 3.436 |
| R-HSA-190861 | Gap junction assembly | 0.000377 | 3.424 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.000398 | 3.400 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.000541 | 3.267 |
| R-HSA-983189 | Kinesins | 0.000546 | 3.263 |
| R-HSA-9663891 | Selective autophagy | 0.000627 | 3.203 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.000683 | 3.166 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.000683 | 3.166 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.000706 | 3.151 |
| R-HSA-430116 | GP1b-IX-V activation signalling | 0.000777 | 3.110 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.000844 | 3.074 |
| R-HSA-68886 | M Phase | 0.000972 | 3.012 |
| R-HSA-5617833 | Cilium Assembly | 0.001132 | 2.946 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.001119 | 2.951 |
| R-HSA-190828 | Gap junction trafficking | 0.001087 | 2.964 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.001177 | 2.929 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.001335 | 2.874 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.001390 | 2.857 |
| R-HSA-9609690 | HCMV Early Events | 0.001394 | 2.856 |
| R-HSA-380287 | Centrosome maturation | 0.001509 | 2.821 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.001657 | 2.781 |
| R-HSA-9833482 | PKR-mediated signaling | 0.002019 | 2.695 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.002431 | 2.614 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.002514 | 2.600 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.002866 | 2.543 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.003301 | 2.481 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.003591 | 2.445 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.003603 | 2.443 |
| R-HSA-8866911 | TFAP2 (AP-2) family regulates transcription of cell cycle factors | 0.003603 | 2.443 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.004187 | 2.378 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.004323 | 2.364 |
| R-HSA-9612973 | Autophagy | 0.004397 | 2.357 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.004858 | 2.314 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.004891 | 2.311 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.004640 | 2.333 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.004891 | 2.311 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.005204 | 2.284 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.005204 | 2.284 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.005271 | 2.278 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.005851 | 2.233 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.006089 | 2.215 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.006089 | 2.215 |
| R-HSA-8941855 | RUNX3 regulates CDKN1A transcription | 0.006284 | 2.202 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.006500 | 2.187 |
| R-HSA-9609646 | HCMV Infection | 0.006857 | 2.164 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.007113 | 2.148 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.007539 | 2.123 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.008492 | 2.071 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.008492 | 2.071 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.008492 | 2.071 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.008492 | 2.071 |
| R-HSA-1632852 | Macroautophagy | 0.009106 | 2.041 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.009604 | 2.018 |
| R-HSA-5620924 | Intraflagellar transport | 0.009604 | 2.018 |
| R-HSA-9726840 | SHOC2 M1731 mutant abolishes MRAS complex function | 0.009634 | 2.016 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 0.009634 | 2.016 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.010854 | 1.964 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.010194 | 1.992 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.010194 | 1.992 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.009708 | 2.013 |
| R-HSA-168256 | Immune System | 0.010914 | 1.962 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.011387 | 1.944 |
| R-HSA-9660537 | Signaling by MRAS-complex mutants | 0.011546 | 1.938 |
| R-HSA-9726842 | Gain-of-function MRAS complexes activate RAF signaling | 0.011546 | 1.938 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.011546 | 1.938 |
| R-HSA-162582 | Signal Transduction | 0.011730 | 1.931 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.011904 | 1.924 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.012882 | 1.890 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.012882 | 1.890 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.013981 | 1.854 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.013986 | 1.854 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.012353 | 1.908 |
| R-HSA-9834752 | Respiratory syncytial virus genome replication | 0.013611 | 1.866 |
| R-HSA-373760 | L1CAM interactions | 0.012748 | 1.895 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.014110 | 1.850 |
| R-HSA-177929 | Signaling by EGFR | 0.014986 | 1.824 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.015768 | 1.802 |
| R-HSA-5689877 | Josephin domain DUBs | 0.015823 | 1.801 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.015823 | 1.801 |
| R-HSA-9820962 | Assembly and release of respiratory syncytial virus (RSV) virions | 0.015823 | 1.801 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.016250 | 1.789 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.016250 | 1.789 |
| R-HSA-8941332 | RUNX2 regulates genes involved in cell migration | 0.018177 | 1.740 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.018177 | 1.740 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.017457 | 1.758 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.017457 | 1.758 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.017409 | 1.759 |
| R-HSA-191859 | snRNP Assembly | 0.017409 | 1.759 |
| R-HSA-391251 | Protein folding | 0.017675 | 1.753 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.019739 | 1.705 |
| R-HSA-163765 | ChREBP activates metabolic gene expression | 0.018177 | 1.740 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.020018 | 1.699 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.020018 | 1.699 |
| R-HSA-354192 | Integrin signaling | 0.020018 | 1.699 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.020757 | 1.683 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.021000 | 1.678 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.021372 | 1.670 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.021372 | 1.670 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.021689 | 1.664 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.024227 | 1.616 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.025728 | 1.590 |
| R-HSA-6798695 | Neutrophil degranulation | 0.024437 | 1.612 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.024227 | 1.616 |
| R-HSA-5673000 | RAF activation | 0.022775 | 1.643 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.024329 | 1.614 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.022775 | 1.643 |
| R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | 0.026051 | 1.584 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.025728 | 1.590 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.027278 | 1.564 |
| R-HSA-5632968 | Defective Mismatch Repair Associated With MSH6 | 0.028767 | 1.541 |
| R-HSA-8875878 | MET promotes cell motility | 0.028877 | 1.539 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.028877 | 1.539 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.028932 | 1.539 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.031848 | 1.497 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 0.031933 | 1.496 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN | 0.031933 | 1.496 |
| R-HSA-446353 | Cell-extracellular matrix interactions | 0.031933 | 1.496 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.032221 | 1.492 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.032221 | 1.492 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.033965 | 1.469 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.034347 | 1.464 |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | 0.042840 | 1.368 |
| R-HSA-5619109 | Defective SLC6A2 causes orthostatic intolerance (OI) | 0.042840 | 1.368 |
| R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins | 0.035051 | 1.455 |
| R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins | 0.041621 | 1.381 |
| R-HSA-9636667 | Manipulation of host energy metabolism | 0.042840 | 1.368 |
| R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 | 0.042840 | 1.368 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.038282 | 1.417 |
| R-HSA-1483148 | Synthesis of PG | 0.038282 | 1.417 |
| R-HSA-9702518 | STAT5 activation downstream of FLT3 ITD mutants | 0.038282 | 1.417 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.035051 | 1.455 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.043216 | 1.364 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.035344 | 1.452 |
| R-HSA-76009 | Platelet Aggregation (Plug Formation) | 0.043403 | 1.362 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.043403 | 1.362 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 0.045066 | 1.346 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.045432 | 1.343 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.048506 | 1.314 |
| R-HSA-1834941 | STING mediated induction of host immune responses | 0.048612 | 1.313 |
| R-HSA-3371556 | Cellular response to heat stress | 0.049251 | 1.308 |
| R-HSA-9665230 | Drug resistance in ERBB2 KD mutants | 0.056710 | 1.246 |
| R-HSA-9652282 | Drug-mediated inhibition of ERBB2 signaling | 0.056710 | 1.246 |
| R-HSA-9665233 | Resistance of ERBB2 KD mutants to trastuzumab | 0.056710 | 1.246 |
| R-HSA-9665245 | Resistance of ERBB2 KD mutants to tesevatinib | 0.056710 | 1.246 |
| R-HSA-9665250 | Resistance of ERBB2 KD mutants to AEE788 | 0.056710 | 1.246 |
| R-HSA-9665737 | Drug resistance in ERBB2 TMD/JMD mutants | 0.056710 | 1.246 |
| R-HSA-3645790 | TGFBR2 Kinase Domain Mutants in Cancer | 0.056710 | 1.246 |
| R-HSA-9665251 | Resistance of ERBB2 KD mutants to lapatinib | 0.056710 | 1.246 |
| R-HSA-9665247 | Resistance of ERBB2 KD mutants to osimertinib | 0.056710 | 1.246 |
| R-HSA-9665246 | Resistance of ERBB2 KD mutants to neratinib | 0.056710 | 1.246 |
| R-HSA-9665244 | Resistance of ERBB2 KD mutants to sapitinib | 0.056710 | 1.246 |
| R-HSA-9665249 | Resistance of ERBB2 KD mutants to afatinib | 0.056710 | 1.246 |
| R-HSA-3656535 | TGFBR1 LBD Mutants in Cancer | 0.056710 | 1.246 |
| R-HSA-5619089 | Defective SLC6A5 causes hyperekplexia 3 (HKPX3) | 0.056710 | 1.246 |
| R-HSA-3642278 | Loss of Function of TGFBR2 in Cancer | 0.056710 | 1.246 |
| R-HSA-112316 | Neuronal System | 0.056858 | 1.245 |
| R-HSA-9825892 | Regulation of MITF-M-dependent genes involved in cell cycle and proliferation | 0.059822 | 1.223 |
| R-HSA-9673766 | Signaling by cytosolic PDGFRA and PDGFRB fusion proteins | 0.070380 | 1.153 |
| R-HSA-9944997 | Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome | 0.070380 | 1.153 |
| R-HSA-9944971 | Loss of Function of KMT2D in Kabuki Syndrome | 0.070380 | 1.153 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.073889 | 1.131 |
| R-HSA-75067 | Processing of Capped Intronless Pre-mRNA | 0.071819 | 1.144 |
| R-HSA-9615933 | Postmitotic nuclear pore complex (NPC) reformation | 0.080210 | 1.096 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.063738 | 1.196 |
| R-HSA-9909396 | Circadian clock | 0.067336 | 1.172 |
| R-HSA-9620244 | Long-term potentiation | 0.075977 | 1.119 |
| R-HSA-5423599 | Diseases of Mismatch Repair (MMR) | 0.070380 | 1.153 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.075874 | 1.120 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.065400 | 1.184 |
| R-HSA-75157 | FasL/ CD95L signaling | 0.070380 | 1.153 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.066351 | 1.178 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.070720 | 1.150 |
| R-HSA-168255 | Influenza Infection | 0.071973 | 1.143 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.068204 | 1.166 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.078881 | 1.103 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.075155 | 1.124 |
| R-HSA-9703648 | Signaling by FLT3 ITD and TKD mutants | 0.071819 | 1.144 |
| R-HSA-70171 | Glycolysis | 0.080907 | 1.092 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.080907 | 1.092 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.081190 | 1.090 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.081190 | 1.090 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.081190 | 1.090 |
| R-HSA-3656532 | TGFBR1 KD Mutants in Cancer | 0.083852 | 1.076 |
| R-HSA-191650 | Regulation of gap junction activity | 0.083852 | 1.076 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.083906 | 1.076 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.085364 | 1.069 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 0.090770 | 1.042 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.093986 | 1.027 |
| R-HSA-3656534 | Loss of Function of TGFBR1 in Cancer | 0.097130 | 1.013 |
| R-HSA-3304356 | SMAD2/3 Phosphorylation Motif Mutants in Cancer | 0.097130 | 1.013 |
| R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | 0.097827 | 1.010 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.098024 | 1.009 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.098024 | 1.009 |
| R-HSA-211000 | Gene Silencing by RNA | 0.098024 | 1.009 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.098057 | 1.009 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.101921 | 0.992 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.102389 | 0.990 |
| R-HSA-186763 | Downstream signal transduction | 0.102389 | 0.990 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.110217 | 0.958 |
| R-HSA-9912481 | Branched-chain ketoacid dehydrogenase kinase deficiency | 0.123114 | 0.910 |
| R-HSA-9732724 | IFNG signaling activates MAPKs | 0.135826 | 0.867 |
| R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs | 0.135826 | 0.867 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.148354 | 0.829 |
| R-HSA-9828211 | Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation | 0.148354 | 0.829 |
| R-HSA-9927426 | Developmental Lineage of Mammary Gland Alveolar Cells | 0.121185 | 0.917 |
| R-HSA-9603381 | Activated NTRK3 signals through PI3K | 0.135826 | 0.867 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.145732 | 0.836 |
| R-HSA-77588 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs | 0.148354 | 0.829 |
| R-HSA-8937144 | Aryl hydrocarbon receptor signalling | 0.110217 | 0.958 |
| R-HSA-3304351 | Signaling by TGF-beta Receptor Complex in Cancer | 0.123114 | 0.910 |
| R-HSA-9820841 | M-decay: degradation of maternal mRNAs by maternally stored factors | 0.155820 | 0.807 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.135789 | 0.867 |
| R-HSA-3304349 | Loss of Function of SMAD2/3 in Cancer | 0.110217 | 0.958 |
| R-HSA-3371511 | HSF1 activation | 0.130878 | 0.883 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.119347 | 0.923 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.111061 | 0.954 |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | 0.132214 | 0.879 |
| R-HSA-5674499 | Negative feedback regulation of MAPK pathway | 0.110217 | 0.958 |
| R-HSA-8964046 | VLDL clearance | 0.135826 | 0.867 |
| R-HSA-442729 | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde | 0.148354 | 0.829 |
| R-HSA-428890 | Role of ABL in ROBO-SLIT signaling | 0.135826 | 0.867 |
| R-HSA-418886 | Netrin mediated repulsion signals | 0.135826 | 0.867 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.107148 | 0.970 |
| R-HSA-877300 | Interferon gamma signaling | 0.119091 | 0.924 |
| R-HSA-162587 | HIV Life Cycle | 0.115042 | 0.939 |
| R-HSA-1251985 | Nuclear signaling by ERBB4 | 0.150759 | 0.822 |
| R-HSA-1253288 | Downregulation of ERBB4 signaling | 0.148354 | 0.829 |
| R-HSA-3371568 | Attenuation phase | 0.150759 | 0.822 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.113098 | 0.947 |
| R-HSA-8852135 | Protein ubiquitination | 0.122518 | 0.912 |
| R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis | 0.155820 | 0.807 |
| R-HSA-75158 | TRAIL signaling | 0.110217 | 0.958 |
| R-HSA-422475 | Axon guidance | 0.127700 | 0.894 |
| R-HSA-9032500 | Activated NTRK2 signals through FYN | 0.148354 | 0.829 |
| R-HSA-5688426 | Deubiquitination | 0.110257 | 0.958 |
| R-HSA-9675108 | Nervous system development | 0.106003 | 0.975 |
| R-HSA-6806834 | Signaling by MET | 0.138823 | 0.858 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.155820 | 0.807 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.144622 | 0.840 |
| R-HSA-109582 | Hemostasis | 0.132231 | 0.879 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.135826 | 0.867 |
| R-HSA-9839389 | TGFBR3 regulates TGF-beta signaling | 0.135826 | 0.867 |
| R-HSA-187687 | Signalling to ERKs | 0.126009 | 0.900 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.110809 | 0.955 |
| R-HSA-2262752 | Cellular responses to stress | 0.126568 | 0.898 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.128953 | 0.890 |
| R-HSA-70326 | Glucose metabolism | 0.126547 | 0.898 |
| R-HSA-9824446 | Viral Infection Pathways | 0.116826 | 0.932 |
| R-HSA-9694548 | Maturation of spike protein | 0.155820 | 0.807 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.132214 | 0.879 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.116207 | 0.935 |
| R-HSA-5619102 | SLC transporter disorders | 0.135942 | 0.867 |
| R-HSA-9679506 | SARS-CoV Infections | 0.139482 | 0.855 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.106877 | 0.971 |
| R-HSA-9820965 | Respiratory syncytial virus (RSV) genome replication, transcription and translat... | 0.145732 | 0.836 |
| R-HSA-164843 | 2-LTR circle formation | 0.172870 | 0.762 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.172870 | 0.762 |
| R-HSA-9824878 | Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | 0.196683 | 0.706 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.196683 | 0.706 |
| R-HSA-3000484 | Scavenging by Class F Receptors | 0.208332 | 0.681 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.219813 | 0.658 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.242280 | 0.616 |
| R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | 0.242280 | 0.616 |
| R-HSA-77595 | Processing of Intronless Pre-mRNAs | 0.264103 | 0.578 |
| R-HSA-5637812 | Signaling by EGFRvIII in Cancer | 0.274778 | 0.561 |
| R-HSA-5637810 | Constitutive Signaling by EGFRvIII | 0.274778 | 0.561 |
| R-HSA-9927418 | Developmental Lineage of Mammary Gland Luminal Epithelial Cells | 0.166036 | 0.780 |
| R-HSA-163210 | Formation of ATP by chemiosmotic coupling | 0.305888 | 0.514 |
| R-HSA-9934037 | Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) | 0.305888 | 0.514 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.186791 | 0.729 |
| R-HSA-72187 | mRNA 3'-end processing | 0.218522 | 0.661 |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | 0.162785 | 0.788 |
| R-HSA-3928664 | Ephrin signaling | 0.285299 | 0.545 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.244016 | 0.613 |
| R-HSA-418457 | cGMP effects | 0.231128 | 0.636 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.264103 | 0.578 |
| R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 | 0.196683 | 0.706 |
| R-HSA-936964 | Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | 0.264103 | 0.578 |
| R-HSA-9609523 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 0.305888 | 0.514 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.274778 | 0.561 |
| R-HSA-418885 | DCC mediated attractive signaling | 0.242280 | 0.616 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.240597 | 0.619 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.240597 | 0.619 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.264103 | 0.578 |
| R-HSA-9619229 | Activation of RAC1 downstream of NMDARs | 0.160701 | 0.794 |
| R-HSA-192905 | vRNP Assembly | 0.184863 | 0.733 |
| R-HSA-9634285 | Constitutive Signaling by Overexpressed ERBB2 | 0.208332 | 0.681 |
| R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | 0.219813 | 0.658 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.219813 | 0.658 |
| R-HSA-8849932 | Synaptic adhesion-like molecules | 0.285299 | 0.545 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.285299 | 0.545 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.256107 | 0.592 |
| R-HSA-69236 | G1 Phase | 0.176365 | 0.754 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.176365 | 0.754 |
| R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants | 0.285299 | 0.545 |
| R-HSA-5358508 | Mismatch Repair | 0.285299 | 0.545 |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | 0.160701 | 0.794 |
| R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells | 0.184863 | 0.733 |
| R-HSA-9933946 | Formation of the embryonic stem cell BAF (esBAF) complex | 0.242280 | 0.616 |
| R-HSA-171007 | p38MAPK events | 0.242280 | 0.616 |
| R-HSA-389513 | Co-inhibition by CTLA4 | 0.305888 | 0.514 |
| R-HSA-8873719 | RAB geranylgeranylation | 0.261425 | 0.583 |
| R-HSA-9707616 | Heme signaling | 0.272185 | 0.565 |
| R-HSA-1433559 | Regulation of KIT signaling | 0.231128 | 0.636 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.242280 | 0.616 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.304399 | 0.517 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.196683 | 0.706 |
| R-HSA-9933939 | Formation of the polybromo-BAF (pBAF) complex | 0.231128 | 0.636 |
| R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | 0.229207 | 0.640 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.272185 | 0.565 |
| R-HSA-8953854 | Metabolism of RNA | 0.270126 | 0.568 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.160913 | 0.793 |
| R-HSA-373752 | Netrin-1 signaling | 0.176365 | 0.754 |
| R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions | 0.219813 | 0.658 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.207114 | 0.684 |
| R-HSA-9665348 | Signaling by ERBB2 ECD mutants | 0.285299 | 0.545 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.260665 | 0.584 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.210117 | 0.678 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.213196 | 0.671 |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | 0.218522 | 0.661 |
| R-HSA-111932 | CaMK IV-mediated phosphorylation of CREB | 0.172870 | 0.762 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.170818 | 0.767 |
| R-HSA-6787450 | tRNA modification in the mitochondrion | 0.264103 | 0.578 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.295669 | 0.529 |
| R-HSA-162592 | Integration of provirus | 0.196683 | 0.706 |
| R-HSA-74160 | Gene expression (Transcription) | 0.306361 | 0.514 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 0.160701 | 0.794 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.208332 | 0.681 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.208332 | 0.681 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.208332 | 0.681 |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | 0.219813 | 0.658 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.305888 | 0.514 |
| R-HSA-162906 | HIV Infection | 0.293852 | 0.532 |
| R-HSA-1227986 | Signaling by ERBB2 | 0.261425 | 0.583 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.253271 | 0.596 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.293680 | 0.532 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.218522 | 0.661 |
| R-HSA-170968 | Frs2-mediated activation | 0.219813 | 0.658 |
| R-HSA-373753 | Nephrin family interactions | 0.305888 | 0.514 |
| R-HSA-8939211 | ESR-mediated signaling | 0.175727 | 0.755 |
| R-HSA-168249 | Innate Immune System | 0.183629 | 0.736 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.291044 | 0.536 |
| R-HSA-8934903 | Receptor Mediated Mitophagy | 0.172870 | 0.762 |
| R-HSA-210990 | PECAM1 interactions | 0.184863 | 0.733 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.295669 | 0.529 |
| R-HSA-392517 | Rap1 signalling | 0.295669 | 0.529 |
| R-HSA-442660 | SLC-mediated transport of neurotransmitters | 0.160913 | 0.793 |
| R-HSA-140875 | Common Pathway of Fibrin Clot Formation | 0.305888 | 0.514 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.210117 | 0.678 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.271752 | 0.566 |
| R-HSA-8956320 | Nucleotide biosynthesis | 0.223859 | 0.650 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.213196 | 0.671 |
| R-HSA-4839726 | Chromatin organization | 0.201966 | 0.695 |
| R-HSA-391908 | Prostanoid ligand receptors | 0.184863 | 0.733 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.208332 | 0.681 |
| R-HSA-8963896 | HDL assembly | 0.231128 | 0.636 |
| R-HSA-169893 | Prolonged ERK activation events | 0.253271 | 0.596 |
| R-HSA-391160 | Signal regulatory protein family interactions | 0.231128 | 0.636 |
| R-HSA-186797 | Signaling by PDGF | 0.272185 | 0.565 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.258775 | 0.587 |
| R-HSA-1295596 | Spry regulation of FGF signaling | 0.242280 | 0.616 |
| R-HSA-180292 | GAB1 signalosome | 0.285299 | 0.545 |
| R-HSA-72306 | tRNA processing | 0.298453 | 0.525 |
| R-HSA-6804760 | Regulation of TP53 Activity through Methylation | 0.285299 | 0.545 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.231542 | 0.635 |
| R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 0.239926 | 0.620 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.272185 | 0.565 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.229072 | 0.640 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.313630 | 0.504 |
| R-HSA-1500931 | Cell-Cell communication | 0.222167 | 0.653 |
| R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | 0.176365 | 0.754 |
| R-HSA-166520 | Signaling by NTRKs | 0.225367 | 0.647 |
| R-HSA-8983711 | OAS antiviral response | 0.208332 | 0.681 |
| R-HSA-391903 | Eicosanoid ligand-binding receptors | 0.305888 | 0.514 |
| R-HSA-1483166 | Synthesis of PA | 0.245295 | 0.610 |
| R-HSA-68875 | Mitotic Prophase | 0.311239 | 0.507 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.202585 | 0.693 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.299355 | 0.524 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.189322 | 0.723 |
| R-HSA-373755 | Semaphorin interactions | 0.277563 | 0.557 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.261425 | 0.583 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.261425 | 0.583 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.261425 | 0.583 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.261425 | 0.583 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.277563 | 0.557 |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | 0.315088 | 0.502 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.288312 | 0.540 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.261425 | 0.583 |
| R-HSA-73887 | Death Receptor Signaling | 0.244016 | 0.613 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.192252 | 0.716 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.217658 | 0.662 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 0.218522 | 0.661 |
| R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer | 0.315960 | 0.500 |
| R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | 0.315960 | 0.500 |
| R-HSA-5602498 | MyD88 deficiency (TLR2/4) | 0.315960 | 0.500 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.315960 | 0.500 |
| R-HSA-167044 | Signalling to RAS | 0.315960 | 0.500 |
| R-HSA-162594 | Early Phase of HIV Life Cycle | 0.315960 | 0.500 |
| R-HSA-73894 | DNA Repair | 0.320266 | 0.494 |
| R-HSA-8978934 | Metabolism of cofactors | 0.320420 | 0.494 |
| R-HSA-9924644 | Developmental Lineages of the Mammary Gland | 0.325741 | 0.487 |
| R-HSA-438066 | Unblocking of NMDA receptors, glutamate binding and activation | 0.325886 | 0.487 |
| R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor | 0.325886 | 0.487 |
| R-HSA-5603041 | IRAK4 deficiency (TLR2/4) | 0.325886 | 0.487 |
| R-HSA-9617324 | Negative regulation of NMDA receptor-mediated neuronal transmission | 0.325886 | 0.487 |
| R-HSA-9034015 | Signaling by NTRK3 (TRKC) | 0.325886 | 0.487 |
| R-HSA-189085 | Digestion of dietary carbohydrate | 0.325886 | 0.487 |
| R-HSA-8876384 | Listeria monocytogenes entry into host cells | 0.325886 | 0.487 |
| R-HSA-9671555 | Signaling by PDGFR in disease | 0.325886 | 0.487 |
| R-HSA-6809371 | Formation of the cornified envelope | 0.327103 | 0.485 |
| R-HSA-597592 | Post-translational protein modification | 0.327773 | 0.484 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.335036 | 0.475 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.335036 | 0.475 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.335036 | 0.475 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.335669 | 0.474 |
| R-HSA-912694 | Regulation of IFNA/IFNB signaling | 0.335669 | 0.474 |
| R-HSA-9670439 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT m... | 0.335669 | 0.474 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.335669 | 0.474 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.335669 | 0.474 |
| R-HSA-9669938 | Signaling by KIT in disease | 0.335669 | 0.474 |
| R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in ... | 0.335669 | 0.474 |
| R-HSA-8964038 | LDL clearance | 0.335669 | 0.474 |
| R-HSA-1236394 | Signaling by ERBB4 | 0.336350 | 0.473 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.341637 | 0.466 |
| R-HSA-69481 | G2/M Checkpoints | 0.342966 | 0.465 |
| R-HSA-114608 | Platelet degranulation | 0.342966 | 0.465 |
| R-HSA-449147 | Signaling by Interleukins | 0.344253 | 0.463 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.345311 | 0.462 |
| R-HSA-879518 | Organic anion transport by SLCO transporters | 0.345311 | 0.462 |
| R-HSA-200425 | Carnitine shuttle | 0.345311 | 0.462 |
| R-HSA-3000170 | Syndecan interactions | 0.345311 | 0.462 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.345311 | 0.462 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.346910 | 0.460 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.346910 | 0.460 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.346928 | 0.460 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.350773 | 0.455 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.352169 | 0.453 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.354813 | 0.450 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.354813 | 0.450 |
| R-HSA-9665686 | Signaling by ERBB2 TMD/JMD mutants | 0.354813 | 0.450 |
| R-HSA-5621575 | CD209 (DC-SIGN) signaling | 0.354813 | 0.450 |
| R-HSA-429947 | Deadenylation of mRNA | 0.354813 | 0.450 |
| R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 | 0.354813 | 0.450 |
| R-HSA-6783589 | Interleukin-6 family signaling | 0.354813 | 0.450 |
| R-HSA-5669034 | TNFs bind their physiological receptors | 0.354813 | 0.450 |
| R-HSA-8963898 | Plasma lipoprotein assembly | 0.354813 | 0.450 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.362644 | 0.441 |
| R-HSA-9932444 | ATP-dependent chromatin remodelers | 0.364178 | 0.439 |
| R-HSA-9932451 | SWI/SNF chromatin remodelers | 0.364178 | 0.439 |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | 0.364178 | 0.439 |
| R-HSA-3000157 | Laminin interactions | 0.364178 | 0.439 |
| R-HSA-5601884 | PIWI-interacting RNA (piRNA) biogenesis | 0.364178 | 0.439 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.368361 | 0.434 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.370641 | 0.431 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.373054 | 0.428 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.373054 | 0.428 |
| R-HSA-1643713 | Signaling by EGFR in Cancer | 0.373407 | 0.428 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.373407 | 0.428 |
| R-HSA-8874081 | MET activates PTK2 signaling | 0.373407 | 0.428 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.373407 | 0.428 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.373407 | 0.428 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.373407 | 0.428 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.373407 | 0.428 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.377203 | 0.423 |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | 0.382503 | 0.417 |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | 0.382503 | 0.417 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.382503 | 0.417 |
| R-HSA-8949613 | Cristae formation | 0.382503 | 0.417 |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | 0.382503 | 0.417 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.382503 | 0.417 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.383396 | 0.416 |
| R-HSA-199991 | Membrane Trafficking | 0.386695 | 0.413 |
| R-HSA-167287 | HIV elongation arrest and recovery | 0.391468 | 0.407 |
| R-HSA-167290 | Pausing and recovery of HIV elongation | 0.391468 | 0.407 |
| R-HSA-622312 | Inflammasomes | 0.391468 | 0.407 |
| R-HSA-5654732 | Negative regulation of FGFR3 signaling | 0.391468 | 0.407 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.398769 | 0.399 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.400303 | 0.398 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.400303 | 0.398 |
| R-HSA-9664565 | Signaling by ERBB2 KD Mutants | 0.400303 | 0.398 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.400303 | 0.398 |
| R-HSA-5654733 | Negative regulation of FGFR4 signaling | 0.400303 | 0.398 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.403855 | 0.394 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.405892 | 0.392 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.408919 | 0.388 |
| R-HSA-1227990 | Signaling by ERBB2 in Cancer | 0.409010 | 0.388 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.409010 | 0.388 |
| R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) | 0.409010 | 0.388 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.409010 | 0.388 |
| R-HSA-8863795 | Downregulation of ERBB2 signaling | 0.409010 | 0.388 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.409010 | 0.388 |
| R-HSA-72172 | mRNA Splicing | 0.413210 | 0.384 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.417591 | 0.379 |
| R-HSA-182971 | EGFR downregulation | 0.417591 | 0.379 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.426049 | 0.371 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.426049 | 0.371 |
| R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | 0.426049 | 0.371 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.429077 | 0.367 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.433921 | 0.363 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.434101 | 0.362 |
| R-HSA-442742 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling | 0.434383 | 0.362 |
| R-HSA-1839124 | FGFR1 mutant receptor activation | 0.434383 | 0.362 |
| R-HSA-9930044 | Nuclear RNA decay | 0.434383 | 0.362 |
| R-HSA-5675482 | Regulation of necroptotic cell death | 0.434383 | 0.362 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.434383 | 0.362 |
| R-HSA-5654726 | Negative regulation of FGFR1 signaling | 0.434383 | 0.362 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.436736 | 0.360 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.438854 | 0.358 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.438854 | 0.358 |
| R-HSA-446728 | Cell junction organization | 0.439618 | 0.357 |
| R-HSA-390522 | Striated Muscle Contraction | 0.442598 | 0.354 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.442598 | 0.354 |
| R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | 0.442598 | 0.354 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.442598 | 0.354 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.444356 | 0.352 |
| R-HSA-5663205 | Infectious disease | 0.445663 | 0.351 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.448649 | 0.348 |
| R-HSA-9680350 | Signaling by CSF1 (M-CSF) in myeloid cells | 0.450694 | 0.346 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.450694 | 0.346 |
| R-HSA-203615 | eNOS activation | 0.450694 | 0.346 |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | 0.450694 | 0.346 |
| R-HSA-5686938 | Regulation of TLR by endogenous ligand | 0.450694 | 0.346 |
| R-HSA-5654727 | Negative regulation of FGFR2 signaling | 0.450694 | 0.346 |
| R-HSA-392518 | Signal amplification | 0.450694 | 0.346 |
| R-HSA-5205647 | Mitophagy | 0.450694 | 0.346 |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 0.463160 | 0.334 |
| R-HSA-1989781 | PPARA activates gene expression | 0.463226 | 0.334 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.466535 | 0.331 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.466535 | 0.331 |
| R-HSA-111933 | Calmodulin induced events | 0.466535 | 0.331 |
| R-HSA-111997 | CaM pathway | 0.466535 | 0.331 |
| R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.466535 | 0.331 |
| R-HSA-8853659 | RET signaling | 0.466535 | 0.331 |
| R-HSA-6804757 | Regulation of TP53 Degradation | 0.466535 | 0.331 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.470697 | 0.327 |
| R-HSA-9610379 | HCMV Late Events | 0.470697 | 0.327 |
| R-HSA-4641258 | Degradation of DVL | 0.474285 | 0.324 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.474285 | 0.324 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.474285 | 0.324 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.474285 | 0.324 |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | 0.474285 | 0.324 |
| R-HSA-9711097 | Cellular response to starvation | 0.474415 | 0.324 |
| R-HSA-3214847 | HATs acetylate histones | 0.477445 | 0.321 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.481815 | 0.317 |
| R-HSA-6785470 | tRNA processing in the mitochondrion | 0.481922 | 0.317 |
| R-HSA-202131 | Metabolism of nitric oxide: NOS3 activation and regulation | 0.481922 | 0.317 |
| R-HSA-73927 | Depurination | 0.481922 | 0.317 |
| R-HSA-5213460 | RIPK1-mediated regulated necrosis | 0.481922 | 0.317 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.486840 | 0.313 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.487303 | 0.312 |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | 0.489449 | 0.310 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.489449 | 0.310 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.489449 | 0.310 |
| R-HSA-69541 | Stabilization of p53 | 0.489449 | 0.310 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.489449 | 0.310 |
| R-HSA-201556 | Signaling by ALK | 0.489449 | 0.310 |
| R-HSA-9648002 | RAS processing | 0.489449 | 0.310 |
| R-HSA-6806003 | Regulation of TP53 Expression and Degradation | 0.489449 | 0.310 |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | 0.496867 | 0.304 |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | 0.496867 | 0.304 |
| R-HSA-167169 | HIV Transcription Elongation | 0.496867 | 0.304 |
| R-HSA-8941858 | Regulation of RUNX3 expression and activity | 0.496867 | 0.304 |
| R-HSA-5602358 | Diseases associated with the TLR signaling cascade | 0.496867 | 0.304 |
| R-HSA-5260271 | Diseases of Immune System | 0.496867 | 0.304 |
| R-HSA-8868766 | rRNA processing in the mitochondrion | 0.496867 | 0.304 |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | 0.500734 | 0.300 |
| R-HSA-72312 | rRNA processing | 0.502277 | 0.299 |
| R-HSA-1643685 | Disease | 0.502864 | 0.299 |
| R-HSA-5218920 | VEGFR2 mediated vascular permeability | 0.504177 | 0.297 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.504177 | 0.297 |
| R-HSA-9833110 | RSV-host interactions | 0.505312 | 0.296 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.509862 | 0.293 |
| R-HSA-5655302 | Signaling by FGFR1 in disease | 0.511382 | 0.291 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.511382 | 0.291 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.514385 | 0.289 |
| R-HSA-111996 | Ca-dependent events | 0.518483 | 0.285 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.518483 | 0.285 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.521599 | 0.283 |
| R-HSA-418555 | G alpha (s) signalling events | 0.525133 | 0.280 |
| R-HSA-5621481 | C-type lectin receptors (CLRs) | 0.525133 | 0.280 |
| R-HSA-1433557 | Signaling by SCF-KIT | 0.525480 | 0.279 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.525480 | 0.279 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.525480 | 0.279 |
| R-HSA-5654743 | Signaling by FGFR4 | 0.525480 | 0.279 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.532160 | 0.274 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.532201 | 0.274 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.532201 | 0.274 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.532377 | 0.274 |
| R-HSA-3928662 | EPHB-mediated forward signaling | 0.532377 | 0.274 |
| R-HSA-4608870 | Asymmetric localization of PCP proteins | 0.539174 | 0.268 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.539174 | 0.268 |
| R-HSA-69601 | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A | 0.539174 | 0.268 |
| R-HSA-69613 | p53-Independent G1/S DNA Damage Checkpoint | 0.539174 | 0.268 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.539174 | 0.268 |
| R-HSA-5654741 | Signaling by FGFR3 | 0.539174 | 0.268 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.540941 | 0.267 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.540941 | 0.267 |
| R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | 0.545872 | 0.263 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.545872 | 0.263 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.545872 | 0.263 |
| R-HSA-9675135 | Diseases of DNA repair | 0.545872 | 0.263 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.545872 | 0.263 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.549568 | 0.260 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.552473 | 0.258 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.552875 | 0.257 |
| R-HSA-2559583 | Cellular Senescence | 0.556288 | 0.255 |
| R-HSA-9634597 | GPER1 signaling | 0.558979 | 0.253 |
| R-HSA-70263 | Gluconeogenesis | 0.558979 | 0.253 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.558979 | 0.253 |
| R-HSA-389356 | Co-stimulation by CD28 | 0.558979 | 0.253 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.562294 | 0.250 |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | 0.562294 | 0.250 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.562386 | 0.250 |
| R-HSA-9766229 | Degradation of CDH1 | 0.565391 | 0.248 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.570635 | 0.244 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.571710 | 0.243 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.574762 | 0.241 |
| R-HSA-5693538 | Homology Directed Repair | 0.574762 | 0.241 |
| R-HSA-1169091 | Activation of NF-kappaB in B cells | 0.577937 | 0.238 |
| R-HSA-9864848 | Complex IV assembly | 0.577937 | 0.238 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.578860 | 0.237 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.578860 | 0.237 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.580319 | 0.236 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.582938 | 0.234 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.584074 | 0.234 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.584074 | 0.234 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.590123 | 0.229 |
| R-HSA-1221632 | Meiotic synapsis | 0.590123 | 0.229 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.590123 | 0.229 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.590982 | 0.228 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.590982 | 0.228 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.592668 | 0.227 |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | 0.594965 | 0.226 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.594965 | 0.226 |
| R-HSA-72649 | Translation initiation complex formation | 0.596083 | 0.225 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.596083 | 0.225 |
| R-HSA-1280218 | Adaptive Immune System | 0.596879 | 0.224 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.601958 | 0.220 |
| R-HSA-194138 | Signaling by VEGF | 0.606740 | 0.217 |
| R-HSA-69206 | G1/S Transition | 0.606740 | 0.217 |
| R-HSA-72702 | Ribosomal scanning and start codon recognition | 0.607747 | 0.216 |
| R-HSA-8935690 | Digestion | 0.607747 | 0.216 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.607747 | 0.216 |
| R-HSA-9764561 | Regulation of CDH1 Function | 0.613453 | 0.212 |
| R-HSA-212436 | Generic Transcription Pathway | 0.615199 | 0.211 |
| R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub... | 0.619075 | 0.208 |
| R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex | 0.619075 | 0.208 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.619075 | 0.208 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.624617 | 0.204 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.624617 | 0.204 |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | 0.625786 | 0.204 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.628842 | 0.201 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.630078 | 0.201 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 0.630078 | 0.201 |
| R-HSA-376176 | Signaling by ROBO receptors | 0.630104 | 0.201 |
| R-HSA-112043 | PLC beta mediated events | 0.635460 | 0.197 |
| R-HSA-450294 | MAP kinase activation | 0.635460 | 0.197 |
| R-HSA-1268020 | Mitochondrial protein import | 0.640764 | 0.193 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.640764 | 0.193 |
| R-HSA-6805567 | Keratinization | 0.642045 | 0.192 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.645991 | 0.190 |
| R-HSA-8963743 | Digestion and absorption | 0.645991 | 0.190 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.651143 | 0.186 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.654766 | 0.184 |
| R-HSA-163685 | Integration of energy metabolism | 0.654766 | 0.184 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.662286 | 0.179 |
| R-HSA-1266738 | Developmental Biology | 0.663337 | 0.178 |
| R-HSA-6807070 | PTEN Regulation | 0.665164 | 0.177 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.665164 | 0.177 |
| R-HSA-112040 | G-protein mediated events | 0.666153 | 0.176 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.668574 | 0.175 |
| R-HSA-9664407 | Parasite infection | 0.668574 | 0.175 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.668574 | 0.175 |
| R-HSA-167172 | Transcription of the HIV genome | 0.671013 | 0.173 |
| R-HSA-5218859 | Regulated Necrosis | 0.671013 | 0.173 |
| R-HSA-9843940 | Regulation of endogenous retroelements by KRAB-ZFP proteins | 0.680521 | 0.167 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.680521 | 0.167 |
| R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 0.680521 | 0.167 |
| R-HSA-75105 | Fatty acyl-CoA biosynthesis | 0.680521 | 0.167 |
| R-HSA-448424 | Interleukin-17 signaling | 0.680521 | 0.167 |
| R-HSA-195721 | Signaling by WNT | 0.683522 | 0.165 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.689755 | 0.161 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.689755 | 0.161 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.694272 | 0.158 |
| R-HSA-4086398 | Ca2+ pathway | 0.694272 | 0.158 |
| R-HSA-69242 | S Phase | 0.698015 | 0.156 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.698724 | 0.156 |
| R-HSA-1226099 | Signaling by FGFR in disease | 0.698724 | 0.156 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.703111 | 0.153 |
| R-HSA-5689603 | UCH proteinases | 0.707435 | 0.150 |
| R-HSA-9609507 | Protein localization | 0.713419 | 0.147 |
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.715894 | 0.145 |
| R-HSA-4086400 | PCP/CE pathway | 0.715894 | 0.145 |
| R-HSA-216083 | Integrin cell surface interactions | 0.715894 | 0.145 |
| R-HSA-9955298 | SLC-mediated transport of organic anions | 0.715894 | 0.145 |
| R-HSA-5654738 | Signaling by FGFR2 | 0.724110 | 0.140 |
| R-HSA-977225 | Amyloid fiber formation | 0.728129 | 0.138 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.732090 | 0.135 |
| R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 0.735993 | 0.133 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.739840 | 0.131 |
| R-HSA-1500620 | Meiosis | 0.743630 | 0.129 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.751048 | 0.124 |
| R-HSA-156902 | Peptide chain elongation | 0.758251 | 0.120 |
| R-HSA-1236974 | ER-Phagosome pathway | 0.761775 | 0.118 |
| R-HSA-202424 | Downstream TCR signaling | 0.765247 | 0.116 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.765247 | 0.116 |
| R-HSA-373080 | Class B/2 (Secretin family receptors) | 0.765247 | 0.116 |
| R-HSA-73884 | Base Excision Repair | 0.765247 | 0.116 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.768474 | 0.114 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.768590 | 0.114 |
| R-HSA-9954714 | PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 0.768669 | 0.114 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.768669 | 0.114 |
| R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 0.772041 | 0.112 |
| R-HSA-156842 | Eukaryotic Translation Elongation | 0.775365 | 0.110 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.775365 | 0.110 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.776022 | 0.110 |
| R-HSA-2029481 | FCGR activation | 0.778640 | 0.109 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.778640 | 0.109 |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | 0.781867 | 0.107 |
| R-HSA-1474290 | Collagen formation | 0.781867 | 0.107 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.782915 | 0.106 |
| R-HSA-9954716 | ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ri... | 0.785048 | 0.105 |
| R-HSA-72689 | Formation of a pool of free 40S subunits | 0.788183 | 0.103 |
| R-HSA-72764 | Eukaryotic Translation Termination | 0.788183 | 0.103 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.791272 | 0.102 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.792770 | 0.101 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.794831 | 0.100 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.797316 | 0.098 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.797316 | 0.098 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.797316 | 0.098 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.797316 | 0.098 |
| R-HSA-190236 | Signaling by FGFR | 0.797316 | 0.098 |
| R-HSA-2408557 | Selenocysteine synthesis | 0.806057 | 0.094 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.808886 | 0.092 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.808886 | 0.092 |
| R-HSA-192823 | Viral mRNA Translation | 0.811674 | 0.091 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.814422 | 0.089 |
| R-HSA-111885 | Opioid Signalling | 0.814422 | 0.089 |
| R-HSA-392499 | Metabolism of proteins | 0.816146 | 0.088 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.816669 | 0.088 |
| R-HSA-9658195 | Leishmania infection | 0.816669 | 0.088 |
| R-HSA-418346 | Platelet homeostasis | 0.822428 | 0.085 |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 0.825020 | 0.084 |
| R-HSA-69239 | Synthesis of DNA | 0.825020 | 0.084 |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | 0.827573 | 0.082 |
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | 0.827573 | 0.082 |
| R-HSA-1236975 | Antigen processing-Cross presentation | 0.827573 | 0.082 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.827573 | 0.082 |
| R-HSA-2672351 | Stimuli-sensing channels | 0.827573 | 0.082 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.830090 | 0.081 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.830090 | 0.081 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.830236 | 0.081 |
| R-HSA-202403 | TCR signaling | 0.832570 | 0.080 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.835883 | 0.078 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.839797 | 0.076 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.844441 | 0.073 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.846712 | 0.072 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.846712 | 0.072 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.848951 | 0.071 |
| R-HSA-72737 | Cap-dependent Translation Initiation | 0.851157 | 0.070 |
| R-HSA-72613 | Eukaryotic Translation Initiation | 0.851157 | 0.070 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.852058 | 0.070 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.861714 | 0.065 |
| R-HSA-418990 | Adherens junctions interactions | 0.863235 | 0.064 |
| R-HSA-9664323 | FCGR3A-mediated IL10 synthesis | 0.873404 | 0.059 |
| R-HSA-1474165 | Reproduction | 0.882389 | 0.054 |
| R-HSA-9843745 | Adipogenesis | 0.884109 | 0.053 |
| R-HSA-15869 | Metabolism of nucleotides | 0.888988 | 0.051 |
| R-HSA-157118 | Signaling by NOTCH | 0.894067 | 0.049 |
| R-HSA-9948299 | Ribosome-associated quality control | 0.896993 | 0.047 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.905711 | 0.043 |
| R-HSA-421270 | Cell-cell junction organization | 0.906946 | 0.042 |
| R-HSA-2871837 | FCERI mediated NF-kB activation | 0.907090 | 0.042 |
| R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors | 0.914957 | 0.039 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.916202 | 0.038 |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 0.917429 | 0.037 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.918550 | 0.037 |
| R-HSA-69306 | DNA Replication | 0.918638 | 0.037 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.920330 | 0.036 |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 0.924423 | 0.034 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.926621 | 0.033 |
| R-HSA-2408522 | Selenoamino acid metabolism | 0.930827 | 0.031 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.935556 | 0.029 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.935810 | 0.029 |
| R-HSA-9662851 | Anti-inflammatory response favouring Leishmania parasite infection | 0.940323 | 0.027 |
| R-HSA-9664433 | Leishmania parasite growth and survival | 0.940323 | 0.027 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.940323 | 0.027 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.940323 | 0.027 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.944571 | 0.025 |
| R-HSA-611105 | Respiratory electron transport | 0.944571 | 0.025 |
| R-HSA-1483257 | Phospholipid metabolism | 0.945199 | 0.024 |
| R-HSA-372790 | Signaling by GPCR | 0.945347 | 0.024 |
| R-HSA-388396 | GPCR downstream signalling | 0.947253 | 0.024 |
| R-HSA-983712 | Ion channel transport | 0.952888 | 0.021 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.957521 | 0.019 |
| R-HSA-428157 | Sphingolipid metabolism | 0.960550 | 0.017 |
| R-HSA-8957322 | Metabolism of steroids | 0.961666 | 0.017 |
| R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 0.961700 | 0.017 |
| R-HSA-5357801 | Programmed Cell Death | 0.963363 | 0.016 |
| R-HSA-1474244 | Extracellular matrix organization | 0.964866 | 0.016 |
| R-HSA-397014 | Muscle contraction | 0.966970 | 0.015 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.968996 | 0.014 |
| R-HSA-8951664 | Neddylation | 0.971092 | 0.013 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.974701 | 0.011 |
| R-HSA-202733 | Cell surface interactions at the vascular wall | 0.977195 | 0.010 |
| R-HSA-418594 | G alpha (i) signalling events | 0.986791 | 0.006 |
| R-HSA-8978868 | Fatty acid metabolism | 0.986791 | 0.006 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.987595 | 0.005 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.995750 | 0.002 |
| R-HSA-382551 | Transport of small molecules | 0.997080 | 0.001 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 0.997836 | 0.001 |
| R-HSA-5668914 | Diseases of metabolism | 0.998681 | 0.001 |
| R-HSA-72766 | Translation | 0.998720 | 0.001 |
| R-HSA-500792 | GPCR ligand binding | 0.998826 | 0.001 |
| R-HSA-211859 | Biological oxidations | 0.999689 | 0.000 |
| R-HSA-556833 | Metabolism of lipids | 0.999886 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
GAK |
0.800 | 0.033 | 1 | 0.217 |
PASK |
0.792 | 0.231 | -3 | 0.841 |
BMPR1B |
0.789 | 0.345 | 1 | 0.438 |
GCK |
0.786 | 0.054 | 1 | 0.243 |
ALK4 |
0.784 | 0.175 | -2 | 0.790 |
TGFBR1 |
0.783 | 0.224 | -2 | 0.757 |
JNK2 |
0.782 | 0.022 | 1 | 0.203 |
DAPK2 |
0.781 | 0.177 | -3 | 0.847 |
TAK1 |
0.780 | -0.056 | 1 | 0.185 |
HPK1 |
0.778 | 0.036 | 1 | 0.232 |
PKR |
0.778 | -0.062 | 1 | 0.167 |
VRK2 |
0.778 | -0.182 | 1 | 0.193 |
DAPK3 |
0.778 | 0.142 | -3 | 0.794 |
ALK2 |
0.777 | 0.145 | -2 | 0.772 |
LATS1 |
0.777 | 0.110 | -3 | 0.852 |
DAPK1 |
0.777 | 0.199 | -3 | 0.769 |
CAMLCK |
0.777 | 0.115 | -2 | 0.903 |
BMPR1A |
0.777 | 0.263 | 1 | 0.412 |
DMPK1 |
0.777 | 0.099 | -3 | 0.760 |
GRK7 |
0.776 | 0.186 | 1 | 0.312 |
JNK3 |
0.776 | 0.005 | 1 | 0.202 |
BIKE |
0.776 | -0.052 | 1 | 0.159 |
ACVR2B |
0.775 | 0.251 | -2 | 0.753 |
MOS |
0.775 | 0.132 | 1 | 0.250 |
MEK1 |
0.774 | 0.008 | 2 | 0.807 |
ASK1 |
0.774 | -0.133 | 1 | 0.162 |
AAK1 |
0.774 | -0.030 | 1 | 0.127 |
KHS1 |
0.773 | -0.054 | 1 | 0.163 |
NIK |
0.773 | 0.009 | -3 | 0.867 |
ACVR2A |
0.773 | 0.248 | -2 | 0.741 |
VRK1 |
0.773 | -0.135 | 2 | 0.778 |
MST3 |
0.773 | 0.027 | 2 | 0.794 |
DLK |
0.773 | 0.081 | 1 | 0.257 |
CAMK1B |
0.773 | 0.109 | -3 | 0.845 |
KHS2 |
0.773 | -0.009 | 1 | 0.198 |
LRRK2 |
0.772 | -0.124 | 2 | 0.802 |
MINK |
0.772 | -0.094 | 1 | 0.167 |
TNIK |
0.772 | -0.082 | 3 | 0.753 |
GRK6 |
0.771 | 0.267 | 1 | 0.330 |
SMMLCK |
0.770 | 0.106 | -3 | 0.794 |
MST1 |
0.770 | -0.092 | 1 | 0.185 |
BRAF |
0.770 | -0.050 | -4 | 0.782 |
LKB1 |
0.769 | -0.076 | -3 | 0.815 |
CAMKK2 |
0.769 | -0.050 | -2 | 0.756 |
MST2 |
0.769 | -0.065 | 1 | 0.207 |
MAP3K15 |
0.769 | -0.116 | 1 | 0.163 |
P38B |
0.768 | -0.007 | 1 | 0.202 |
BMPR2 |
0.768 | -0.083 | -2 | 0.837 |
ALPHAK3 |
0.768 | -0.071 | -1 | 0.747 |
EEF2K |
0.768 | -0.071 | 3 | 0.730 |
PBK |
0.767 | -0.059 | 1 | 0.145 |
PDK1 |
0.767 | -0.109 | 1 | 0.161 |
SKMLCK |
0.767 | 0.164 | -2 | 0.907 |
DRAK1 |
0.767 | 0.338 | 1 | 0.435 |
MEK5 |
0.766 | -0.136 | 2 | 0.789 |
GRK2 |
0.766 | 0.278 | -2 | 0.710 |
TAO3 |
0.766 | -0.052 | 1 | 0.202 |
NEK1 |
0.765 | -0.160 | 1 | 0.136 |
ROCK2 |
0.765 | 0.064 | -3 | 0.783 |
OSR1 |
0.765 | -0.068 | 2 | 0.766 |
NEK11 |
0.764 | -0.077 | 1 | 0.210 |
CAMKK1 |
0.764 | -0.082 | -2 | 0.749 |
TAO2 |
0.764 | -0.115 | 2 | 0.785 |
P38A |
0.764 | -0.017 | 1 | 0.199 |
HGK |
0.764 | -0.121 | 3 | 0.742 |
P38G |
0.764 | -0.002 | 1 | 0.211 |
MPSK1 |
0.763 | -0.069 | 1 | 0.140 |
MEKK6 |
0.763 | -0.118 | 1 | 0.163 |
HIPK1 |
0.762 | 0.035 | 1 | 0.192 |
PRPK |
0.762 | -0.058 | -1 | 0.819 |
JNK1 |
0.762 | 0.009 | 1 | 0.228 |
NLK |
0.762 | -0.006 | 1 | 0.229 |
ICK |
0.762 | 0.012 | -3 | 0.818 |
PLK1 |
0.761 | 0.151 | -2 | 0.753 |
CLK3 |
0.760 | 0.121 | 1 | 0.247 |
STLK3 |
0.760 | -0.140 | 1 | 0.165 |
MEKK2 |
0.760 | -0.163 | 2 | 0.757 |
ATR |
0.759 | -0.040 | 1 | 0.187 |
TTK |
0.759 | -0.106 | -2 | 0.771 |
MEKK3 |
0.759 | -0.058 | 1 | 0.216 |
YSK4 |
0.758 | -0.089 | 1 | 0.180 |
CRIK |
0.758 | 0.070 | -3 | 0.695 |
MYO3B |
0.758 | -0.110 | 2 | 0.772 |
NEK5 |
0.758 | -0.183 | 1 | 0.152 |
GRK5 |
0.758 | 0.148 | -3 | 0.852 |
YSK1 |
0.757 | -0.120 | 2 | 0.758 |
BUB1 |
0.756 | 0.055 | -5 | 0.803 |
LOK |
0.756 | -0.070 | -2 | 0.779 |
NEK8 |
0.756 | -0.138 | 2 | 0.770 |
MYO3A |
0.756 | -0.134 | 1 | 0.153 |
CK2A2 |
0.756 | 0.282 | 1 | 0.395 |
CDKL1 |
0.755 | -0.011 | -3 | 0.774 |
NEK4 |
0.755 | -0.167 | 1 | 0.133 |
CDC7 |
0.755 | 0.214 | 1 | 0.307 |
P38D |
0.755 | -0.008 | 1 | 0.147 |
ANKRD3 |
0.754 | -0.132 | 1 | 0.193 |
CDK1 |
0.754 | 0.014 | 1 | 0.253 |
RSK2 |
0.754 | 0.177 | -3 | 0.757 |
DYRK2 |
0.753 | 0.018 | 1 | 0.193 |
PRP4 |
0.753 | -0.023 | -3 | 0.753 |
CK2A1 |
0.753 | 0.295 | 1 | 0.416 |
MEKK1 |
0.753 | -0.187 | 1 | 0.154 |
MRCKA |
0.753 | 0.072 | -3 | 0.743 |
MEK2 |
0.753 | -0.164 | 2 | 0.777 |
ZAK |
0.753 | -0.125 | 1 | 0.188 |
CAMK2G |
0.753 | 0.036 | 2 | 0.781 |
GRK1 |
0.752 | 0.196 | -2 | 0.780 |
RAF1 |
0.752 | -0.015 | 1 | 0.209 |
MAK |
0.752 | 0.020 | -2 | 0.744 |
ERK5 |
0.751 | -0.035 | 1 | 0.213 |
PIM1 |
0.751 | 0.060 | -3 | 0.778 |
HASPIN |
0.751 | -0.003 | -1 | 0.725 |
P70S6KB |
0.751 | 0.098 | -3 | 0.778 |
CLK4 |
0.751 | 0.095 | -3 | 0.758 |
ROCK1 |
0.750 | 0.047 | -3 | 0.743 |
PIM3 |
0.750 | 0.090 | -3 | 0.828 |
ERK2 |
0.750 | -0.040 | 1 | 0.202 |
MYLK4 |
0.750 | 0.147 | -2 | 0.876 |
CDK14 |
0.750 | 0.008 | 1 | 0.213 |
TLK2 |
0.749 | -0.073 | 1 | 0.157 |
RSK4 |
0.749 | 0.183 | -3 | 0.729 |
DYRK1B |
0.749 | 0.022 | 1 | 0.208 |
DYRK4 |
0.748 | 0.036 | 1 | 0.190 |
COT |
0.748 | 0.128 | 2 | 0.817 |
GSK3B |
0.748 | 0.084 | 4 | 0.556 |
DCAMKL1 |
0.748 | 0.010 | -3 | 0.796 |
ERK1 |
0.747 | -0.025 | 1 | 0.186 |
MOK |
0.747 | 0.003 | 1 | 0.181 |
SLK |
0.747 | -0.068 | -2 | 0.713 |
GSK3A |
0.747 | 0.086 | 4 | 0.563 |
TSSK2 |
0.747 | 0.037 | -5 | 0.843 |
MSK1 |
0.747 | 0.155 | -3 | 0.728 |
PKN3 |
0.747 | -0.005 | -3 | 0.812 |
PIM2 |
0.746 | 0.052 | -3 | 0.729 |
CLK2 |
0.746 | 0.145 | -3 | 0.745 |
MRCKB |
0.746 | 0.057 | -3 | 0.725 |
HIPK2 |
0.745 | 0.031 | 1 | 0.173 |
SGK3 |
0.745 | 0.067 | -3 | 0.755 |
DNAPK |
0.745 | -0.060 | 1 | 0.110 |
WNK1 |
0.745 | -0.016 | -2 | 0.877 |
MLK2 |
0.744 | -0.157 | 2 | 0.777 |
PKN2 |
0.744 | 0.048 | -3 | 0.833 |
PDHK4 |
0.744 | -0.112 | 1 | 0.206 |
PLK3 |
0.744 | 0.019 | 2 | 0.753 |
MST4 |
0.744 | 0.027 | 2 | 0.821 |
AKT2 |
0.744 | 0.074 | -3 | 0.676 |
PERK |
0.743 | -0.152 | -2 | 0.788 |
P90RSK |
0.743 | 0.112 | -3 | 0.754 |
CAMK2B |
0.743 | 0.117 | 2 | 0.764 |
CDK17 |
0.743 | -0.011 | 1 | 0.216 |
GRK3 |
0.743 | 0.232 | -2 | 0.675 |
DCAMKL2 |
0.743 | -0.009 | -3 | 0.810 |
RIPK1 |
0.743 | -0.087 | 1 | 0.171 |
AMPKA1 |
0.742 | 0.007 | -3 | 0.852 |
PAK1 |
0.742 | 0.082 | -2 | 0.868 |
TLK1 |
0.742 | -0.112 | -2 | 0.778 |
CHAK2 |
0.742 | -0.065 | -1 | 0.820 |
DYRK3 |
0.742 | 0.037 | 1 | 0.179 |
CAMK2A |
0.741 | 0.134 | 2 | 0.769 |
MASTL |
0.741 | -0.130 | -2 | 0.769 |
AURB |
0.741 | 0.140 | -2 | 0.818 |
HIPK3 |
0.741 | -0.012 | 1 | 0.161 |
CDK3 |
0.741 | -0.004 | 1 | 0.216 |
HUNK |
0.741 | 0.018 | 2 | 0.783 |
CDK5 |
0.741 | -0.025 | 1 | 0.210 |
AURA |
0.741 | 0.164 | -2 | 0.792 |
SGK1 |
0.741 | 0.070 | -3 | 0.593 |
WNK4 |
0.741 | -0.111 | -2 | 0.851 |
DYRK1A |
0.741 | -0.005 | 1 | 0.186 |
PKCD |
0.741 | 0.003 | 2 | 0.724 |
CDK10 |
0.740 | 0.024 | 1 | 0.210 |
CDK16 |
0.740 | -0.008 | 1 | 0.208 |
TAO1 |
0.740 | -0.144 | 1 | 0.129 |
MTOR |
0.739 | -0.060 | 1 | 0.203 |
PAK2 |
0.739 | 0.055 | -2 | 0.853 |
CHK1 |
0.739 | -0.016 | -3 | 0.817 |
CAMK2D |
0.738 | 0.029 | -3 | 0.821 |
CDK18 |
0.738 | -0.003 | 1 | 0.201 |
HIPK4 |
0.738 | 0.019 | 1 | 0.180 |
CDK2 |
0.738 | -0.008 | 1 | 0.288 |
PDHK1 |
0.738 | -0.155 | 1 | 0.169 |
NEK2 |
0.737 | -0.114 | 2 | 0.761 |
TSSK1 |
0.737 | 0.023 | -3 | 0.872 |
PKACB |
0.737 | 0.150 | -2 | 0.831 |
CLK1 |
0.737 | 0.073 | -3 | 0.739 |
MLK1 |
0.737 | -0.112 | 2 | 0.764 |
RIPK3 |
0.737 | -0.042 | 3 | 0.622 |
CAMK4 |
0.737 | 0.044 | -3 | 0.815 |
PKACG |
0.736 | 0.113 | -2 | 0.864 |
NUAK2 |
0.736 | 0.020 | -3 | 0.837 |
HRI |
0.736 | -0.204 | -2 | 0.797 |
NEK9 |
0.736 | -0.168 | 2 | 0.783 |
CDK4 |
0.736 | -0.035 | 1 | 0.185 |
AURC |
0.735 | 0.175 | -2 | 0.824 |
CAMK1D |
0.735 | 0.045 | -3 | 0.675 |
DSTYK |
0.735 | -0.028 | 2 | 0.834 |
CDK6 |
0.734 | -0.043 | 1 | 0.182 |
MAPKAPK3 |
0.734 | 0.048 | -3 | 0.771 |
PLK2 |
0.733 | 0.027 | -3 | 0.759 |
NDR1 |
0.733 | 0.067 | -3 | 0.829 |
CDKL5 |
0.733 | -0.030 | -3 | 0.765 |
CDK12 |
0.733 | -0.024 | 1 | 0.188 |
CDK13 |
0.733 | -0.030 | 1 | 0.192 |
MAPKAPK2 |
0.732 | 0.103 | -3 | 0.727 |
AKT1 |
0.732 | 0.060 | -3 | 0.699 |
AMPKA2 |
0.732 | 0.003 | -3 | 0.819 |
PKG2 |
0.732 | 0.116 | -2 | 0.836 |
ATM |
0.731 | -0.060 | 1 | 0.165 |
CDK7 |
0.730 | -0.021 | 1 | 0.200 |
MSK2 |
0.730 | 0.077 | -3 | 0.722 |
PAK3 |
0.730 | 0.035 | -2 | 0.857 |
SRPK1 |
0.730 | 0.014 | -3 | 0.734 |
TBK1 |
0.730 | -0.131 | 1 | 0.143 |
MLK4 |
0.730 | -0.070 | 2 | 0.681 |
RSK3 |
0.729 | 0.081 | -3 | 0.747 |
CAMK1G |
0.729 | 0.021 | -3 | 0.741 |
TGFBR2 |
0.729 | 0.013 | -2 | 0.761 |
MLK3 |
0.729 | -0.075 | 2 | 0.688 |
ERK7 |
0.729 | -0.045 | 2 | 0.500 |
IRAK4 |
0.729 | -0.173 | 1 | 0.113 |
CHK2 |
0.728 | 0.012 | -3 | 0.629 |
MARK4 |
0.728 | -0.028 | 4 | 0.783 |
MNK1 |
0.728 | 0.074 | -2 | 0.885 |
CDK8 |
0.728 | -0.030 | 1 | 0.195 |
CDK9 |
0.728 | -0.035 | 1 | 0.190 |
PRKD1 |
0.727 | 0.046 | -3 | 0.822 |
GRK4 |
0.727 | 0.020 | -2 | 0.793 |
NEK3 |
0.727 | -0.188 | 1 | 0.102 |
SMG1 |
0.726 | -0.103 | 1 | 0.147 |
NDR2 |
0.726 | 0.112 | -3 | 0.842 |
SRPK3 |
0.726 | -0.006 | -3 | 0.697 |
PKCA |
0.725 | -0.009 | 2 | 0.667 |
PRKD3 |
0.725 | 0.017 | -3 | 0.739 |
IKKE |
0.725 | -0.126 | 1 | 0.143 |
PKCH |
0.725 | -0.019 | 2 | 0.659 |
PKACA |
0.724 | 0.125 | -2 | 0.803 |
PRKD2 |
0.723 | 0.068 | -3 | 0.773 |
CHAK1 |
0.723 | -0.159 | 2 | 0.744 |
ULK2 |
0.723 | -0.152 | 2 | 0.744 |
IKKB |
0.723 | -0.032 | -2 | 0.728 |
PINK1 |
0.723 | -0.191 | 1 | 0.180 |
PRKX |
0.722 | 0.166 | -3 | 0.686 |
LATS2 |
0.722 | 0.047 | -5 | 0.781 |
WNK3 |
0.722 | -0.167 | 1 | 0.150 |
MELK |
0.722 | -0.037 | -3 | 0.798 |
IKKA |
0.722 | 0.026 | -2 | 0.703 |
SSTK |
0.722 | 0.000 | 4 | 0.743 |
P70S6K |
0.722 | 0.049 | -3 | 0.680 |
SBK |
0.721 | 0.014 | -3 | 0.558 |
MNK2 |
0.721 | 0.063 | -2 | 0.877 |
TTBK2 |
0.721 | -0.126 | 2 | 0.670 |
PKCB |
0.721 | -0.015 | 2 | 0.669 |
PKCG |
0.721 | 0.004 | 2 | 0.677 |
NEK7 |
0.720 | -0.155 | -3 | 0.813 |
PKCE |
0.720 | 0.019 | 2 | 0.660 |
CDK19 |
0.720 | -0.021 | 1 | 0.188 |
PDHK3_TYR |
0.720 | 0.227 | 4 | 0.858 |
PKCZ |
0.719 | -0.072 | 2 | 0.720 |
CAMK1A |
0.719 | 0.022 | -3 | 0.651 |
MARK1 |
0.717 | 0.027 | 4 | 0.741 |
IRE1 |
0.717 | -0.140 | 1 | 0.137 |
MARK3 |
0.717 | 0.040 | 4 | 0.721 |
NEK6 |
0.717 | -0.107 | -2 | 0.808 |
STK33 |
0.716 | -0.099 | 2 | 0.611 |
PDHK4_TYR |
0.715 | 0.178 | 2 | 0.861 |
MARK2 |
0.715 | 0.002 | 4 | 0.676 |
RIPK2 |
0.715 | -0.176 | 1 | 0.149 |
QIK |
0.715 | -0.055 | -3 | 0.815 |
PKCI |
0.715 | -0.022 | 2 | 0.684 |
PLK4 |
0.714 | -0.114 | 2 | 0.635 |
QSK |
0.714 | -0.001 | 4 | 0.759 |
BMPR2_TYR |
0.714 | 0.235 | -1 | 0.877 |
AKT3 |
0.714 | 0.060 | -3 | 0.616 |
IRAK1 |
0.713 | -0.206 | -1 | 0.728 |
PAK6 |
0.712 | 0.090 | -2 | 0.819 |
IRE2 |
0.712 | -0.152 | 2 | 0.686 |
NIM1 |
0.712 | -0.091 | 3 | 0.675 |
YANK3 |
0.712 | -0.011 | 2 | 0.414 |
GCN2 |
0.711 | -0.116 | 2 | 0.772 |
ULK1 |
0.711 | -0.112 | -3 | 0.797 |
CK1D |
0.711 | 0.040 | -3 | 0.550 |
CK1A2 |
0.710 | 0.056 | -3 | 0.548 |
PKCT |
0.710 | -0.047 | 2 | 0.669 |
BCKDK |
0.710 | -0.105 | -1 | 0.770 |
MAP2K6_TYR |
0.709 | 0.158 | -1 | 0.852 |
BRSK1 |
0.709 | 0.057 | -3 | 0.785 |
SRPK2 |
0.708 | 0.004 | -3 | 0.650 |
TESK1_TYR |
0.706 | 0.027 | 3 | 0.797 |
PDHK1_TYR |
0.706 | 0.109 | -1 | 0.862 |
MAP2K4_TYR |
0.705 | 0.052 | -1 | 0.837 |
CK1E |
0.702 | 0.050 | -3 | 0.596 |
MAP2K7_TYR |
0.701 | -0.068 | 2 | 0.834 |
KIS |
0.701 | 0.002 | 1 | 0.179 |
PHKG1 |
0.701 | -0.087 | -3 | 0.822 |
NUAK1 |
0.700 | -0.050 | -3 | 0.781 |
SNRK |
0.700 | -0.087 | 2 | 0.687 |
SIK |
0.700 | -0.033 | -3 | 0.752 |
PKN1 |
0.700 | -0.033 | -3 | 0.707 |
PAK5 |
0.699 | 0.061 | -2 | 0.760 |
LIMK2_TYR |
0.698 | -0.032 | -3 | 0.877 |
PINK1_TYR |
0.698 | -0.072 | 1 | 0.218 |
BRSK2 |
0.697 | -0.041 | -3 | 0.808 |
TTBK1 |
0.697 | -0.133 | 2 | 0.596 |
PKMYT1_TYR |
0.697 | -0.073 | 3 | 0.761 |
MAPKAPK5 |
0.697 | -0.065 | -3 | 0.685 |
EPHA6 |
0.697 | 0.055 | -1 | 0.850 |
TXK |
0.696 | 0.213 | 1 | 0.364 |
YANK2 |
0.696 | -0.034 | 2 | 0.420 |
FAM20C |
0.695 | 0.016 | 2 | 0.597 |
PTK2 |
0.694 | 0.222 | -1 | 0.843 |
PHKG2 |
0.691 | -0.056 | -3 | 0.799 |
EPHB4 |
0.691 | 0.018 | -1 | 0.804 |
PAK4 |
0.690 | 0.065 | -2 | 0.771 |
EPHA4 |
0.690 | 0.044 | 2 | 0.763 |
RET |
0.689 | -0.162 | 1 | 0.160 |
SRMS |
0.686 | 0.075 | 1 | 0.297 |
FGR |
0.686 | -0.019 | 1 | 0.246 |
MST1R |
0.685 | -0.165 | 3 | 0.689 |
SYK |
0.685 | 0.141 | -1 | 0.801 |
DDR1 |
0.685 | -0.103 | 4 | 0.761 |
INSRR |
0.685 | -0.001 | 3 | 0.621 |
EPHB1 |
0.684 | 0.041 | 1 | 0.274 |
LIMK1_TYR |
0.684 | -0.155 | 2 | 0.808 |
PKG1 |
0.684 | 0.051 | -2 | 0.779 |
JAK3 |
0.684 | -0.113 | 1 | 0.173 |
FGFR2 |
0.684 | -0.110 | 3 | 0.692 |
YES1 |
0.683 | -0.044 | -1 | 0.789 |
FER |
0.683 | -0.036 | 1 | 0.262 |
NEK10_TYR |
0.682 | -0.131 | 1 | 0.108 |
ITK |
0.681 | 0.059 | -1 | 0.756 |
PTK2B |
0.681 | 0.140 | -1 | 0.704 |
EPHB2 |
0.680 | 0.007 | -1 | 0.786 |
FYN |
0.680 | 0.035 | -1 | 0.798 |
CSF1R |
0.680 | -0.149 | 3 | 0.663 |
TYK2 |
0.679 | -0.273 | 1 | 0.140 |
MERTK |
0.679 | 0.013 | 3 | 0.666 |
TYRO3 |
0.679 | -0.129 | 3 | 0.661 |
ABL2 |
0.679 | -0.078 | -1 | 0.747 |
EGFR |
0.678 | -0.027 | 1 | 0.223 |
EPHB3 |
0.677 | -0.037 | -1 | 0.786 |
FLT1 |
0.677 | -0.056 | -1 | 0.832 |
BMX |
0.677 | 0.048 | -1 | 0.676 |
JAK2 |
0.677 | -0.250 | 1 | 0.140 |
ABL1 |
0.677 | -0.089 | -1 | 0.737 |
EPHA7 |
0.676 | 0.014 | 2 | 0.756 |
KDR |
0.676 | -0.115 | 3 | 0.624 |
EPHA3 |
0.676 | -0.010 | 2 | 0.742 |
KIT |
0.676 | -0.114 | 3 | 0.671 |
ROS1 |
0.676 | -0.166 | 3 | 0.621 |
TNK2 |
0.675 | -0.114 | 3 | 0.631 |
MET |
0.674 | -0.066 | 3 | 0.662 |
ERBB2 |
0.674 | -0.083 | 1 | 0.226 |
FGFR3 |
0.674 | -0.099 | 3 | 0.661 |
PDGFRB |
0.674 | -0.150 | 3 | 0.664 |
HCK |
0.674 | -0.091 | -1 | 0.790 |
EPHA5 |
0.674 | 0.016 | 2 | 0.752 |
AXL |
0.673 | -0.084 | 3 | 0.651 |
FGFR1 |
0.672 | -0.179 | 3 | 0.641 |
NTRK1 |
0.672 | -0.069 | -1 | 0.782 |
LCK |
0.672 | -0.076 | -1 | 0.802 |
ERBB4 |
0.671 | 0.025 | 1 | 0.286 |
EPHA8 |
0.671 | 0.006 | -1 | 0.789 |
WEE1_TYR |
0.671 | -0.074 | -1 | 0.712 |
TNK1 |
0.670 | -0.144 | 3 | 0.653 |
DDR2 |
0.670 | -0.054 | 3 | 0.606 |
FLT3 |
0.670 | -0.192 | 3 | 0.658 |
BLK |
0.670 | -0.073 | -1 | 0.799 |
TEK |
0.669 | -0.155 | 3 | 0.602 |
TEC |
0.668 | -0.014 | -1 | 0.661 |
FLT4 |
0.668 | -0.133 | 3 | 0.641 |
NTRK3 |
0.667 | -0.060 | -1 | 0.736 |
INSR |
0.666 | -0.087 | 3 | 0.598 |
JAK1 |
0.666 | -0.180 | 1 | 0.129 |
SRC |
0.666 | -0.032 | -1 | 0.771 |
EPHA2 |
0.665 | 0.025 | -1 | 0.767 |
TNNI3K_TYR |
0.665 | -0.166 | 1 | 0.122 |
FRK |
0.665 | -0.095 | -1 | 0.783 |
PDGFRA |
0.664 | -0.231 | 3 | 0.660 |
EPHA1 |
0.664 | -0.102 | 3 | 0.633 |
LTK |
0.664 | -0.124 | 3 | 0.615 |
NTRK2 |
0.663 | -0.132 | 3 | 0.632 |
ALK |
0.662 | -0.117 | 3 | 0.578 |
CK1G1 |
0.662 | -0.042 | -3 | 0.592 |
FGFR4 |
0.662 | -0.095 | -1 | 0.733 |
MATK |
0.661 | -0.075 | -1 | 0.689 |
BTK |
0.661 | -0.147 | -1 | 0.704 |
CSK |
0.660 | -0.095 | 2 | 0.762 |
PTK6 |
0.660 | -0.177 | -1 | 0.674 |
CK1G3 |
0.659 | -0.025 | -3 | 0.420 |
MUSK |
0.658 | -0.093 | 1 | 0.207 |
ZAP70 |
0.658 | 0.004 | -1 | 0.722 |
IGF1R |
0.658 | -0.041 | 3 | 0.549 |
LYN |
0.657 | -0.110 | 3 | 0.594 |
CK1A |
0.650 | 0.078 | -3 | 0.467 |
FES |
0.650 | 0.038 | -1 | 0.657 |
CK1G2 |
0.647 | 0.003 | -3 | 0.512 |