Motif 103 (n=223)
Position-wise Probabilities
Download
| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A0AV02 | SLC12A8 | S665 | ochoa | Solute carrier family 12 member 8 (Cation-chloride cotransporter 9) | Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO:0000269|PubMed:11863360}. |
| A4FU49 | SH3D21 | S269 | ochoa | SH3 domain-containing protein 21 | None |
| A6NJL1 | ZSCAN5B | S295 | ochoa | Zinc finger and SCAN domain-containing protein 5B | May be involved in transcriptional regulation. {ECO:0000250}. |
| A6NKT7 | RGPD3 | T897 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A7KAX9 | ARHGAP32 | S892 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| O14654 | IRS4 | S818 | ochoa | Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160) | Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2. {ECO:0000269|PubMed:10531310, ECO:0000269|PubMed:10594015, ECO:0000269|PubMed:12639902, ECO:0000269|PubMed:17408801, ECO:0000269|PubMed:9553137}. |
| O14715 | RGPD8 | T896 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15018 | PDZD2 | S1422 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15018 | PDZD2 | S1850 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15119 | TBX3 | S456 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O15119 | TBX3 | S707 | ochoa | T-box transcription factor TBX3 (T-box protein 3) | Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). {ECO:0000250|UniProtKB:P70324, ECO:0000269|PubMed:10468588, ECO:0000269|PubMed:12000749, ECO:0000269|PubMed:22002537}. |
| O15195 | VILL | S723 | ochoa | Villin-like protein | Possible tumor suppressor. |
| O15226 | NKRF | S429 | ochoa | NF-kappa-B-repressing factor (NFkB-repressing factor) (NRF) (Protein ITBA4) | Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}. |
| O15379 | HDAC3 | S74 | ochoa | Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45) | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:21030595, PubMed:21444723, PubMed:23911289, PubMed:25301942, PubMed:28167758, PubMed:28497810, PubMed:32404892, PubMed:22230954). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:23911289). Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity (PubMed:23911289, PubMed:22230954). Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression (PubMed:23911289). Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (By similarity). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803). Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). During the activation phase, promotes the accumulation of ubiquitinated BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and BMAL1 (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). Also functions as a deacetylase for non-histone targets, such as KAT5, MEF2D, MAPK14, RARA and STAT3 (PubMed:15653507, PubMed:21030595, PubMed:21444723, PubMed:25301942, PubMed:28167758). Serves as a corepressor of RARA, mediating its deacetylation and repression, leading to inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (PubMed:28497810, PubMed:29192674, PubMed:34608293, PubMed:35044827). Catalyzes decrotonylation of MAPRE1/EB1 (PubMed:34608293). Mediates delactylation NBN/NBS1, thereby inhibiting DNA double-strand breaks (DSBs) via homologous recombination (HR) (PubMed:38961290). {ECO:0000250|UniProtKB:O88895, ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:21444723, ECO:0000269|PubMed:22230954, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:25190803, ECO:0000269|PubMed:25301942, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:29192674, ECO:0000269|PubMed:32404892, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:35044827, ECO:0000269|PubMed:38961290}. |
| O43166 | SIPA1L1 | S162 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43166 | SIPA1L1 | S384 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43166 | SIPA1L1 | S1149 | ochoa | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| O43315 | AQP9 | S222 | psp | Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1) | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10564231, PubMed:30420639, PubMed:35054513, PubMed:9514918). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed:10564231). AQP9 may also facilitate hepatic urea extrusion (PubMed:10564231, PubMed:9514918). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:10564231, PubMed:35054513). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:10564231). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity). {ECO:0000250|UniProtKB:P56627, ECO:0000250|UniProtKB:Q9JJJ3, ECO:0000269|PubMed:10564231, ECO:0000269|PubMed:26837049, ECO:0000269|PubMed:30420639, ECO:0000269|PubMed:35054513, ECO:0000269|PubMed:9514918}. |
| O43572 | AKAP10 | S278 | ochoa | A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10) | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}. |
| O60333 | KIF1B | S1162 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60673 | REV3L | S2147 | ochoa | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. {ECO:0000269|PubMed:24449906}. |
| O75145 | PPFIA3 | S683 | ochoa | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
| O75167 | PHACTR2 | S237 | ochoa | Phosphatase and actin regulator 2 | None |
| O75362 | ZNF217 | S1004 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75400 | PRPF40A | S151 | ochoa | Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6) | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:21834987}. |
| O75509 | TNFRSF21 | S565 | ochoa | Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358) | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (PubMed:34012073). {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:22761420, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:9714541}. |
| O75807 | PPP1R15A | S143 | ochoa | Protein phosphatase 1 regulatory subunit 15A (Growth arrest and DNA damage-inducible protein GADD34) (Myeloid differentiation primary response protein MyD116 homolog) | Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26095357, PubMed:26742780). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (PubMed:14718519). May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' (PubMed:14635196). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). Also acts a viral restriction factor by attenuating HIV-1 replication (PubMed:31778897). Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation (PubMed:31778897). {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:26095357, ECO:0000269|PubMed:31778897, ECO:0000269|PubMed:8139541}.; FUNCTION: (Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR. {ECO:0000269|PubMed:34985336}. |
| O75970 | MPDZ | S483 | ochoa | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:11150294, PubMed:15312654). Promotes clustering of HT2RC at the cell surface (By similarity). {ECO:0000250|UniProtKB:O55164, ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:15312654}. |
| O76039 | CDKL5 | S761 | ochoa | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) | Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860, ECO:0000269|PubMed:29420175}. |
| O95835 | LATS1 | S613 | ochoa|psp | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P02549 | SPTA1 | S1363 | ochoa | Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin) | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. |
| P04150 | NR3C1 | S226 | psp | Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) | Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:28139699, ECO:0000269|PubMed:37478846, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:11435610, PubMed:15769988, PubMed:15866175, PubMed:17635946, PubMed:19141540, PubMed:19248771, PubMed:20484466, PubMed:21664385, PubMed:23820903). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:20484466, PubMed:7769088, PubMed:8621628). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}. |
| P08151 | GLI1 | S116 | psp | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) | Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269|PubMed:19706761}. |
| P0DJD0 | RGPD1 | T881 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | T889 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DMB2 | C8orf88 | S70 | ochoa | Uncharacterized protein C8orf88 | None |
| P10070 | GLI2 | S1101 | ochoa | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) | Functions as a transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as a transcriptional activator (PubMed:19878745, PubMed:24311597, PubMed:9557682). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| P14316 | IRF2 | S155 | ochoa | Interferon regulatory factor 2 (IRF-2) | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}. |
| P15822 | HIVEP1 | S188 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P15822 | HIVEP1 | S2327 | ochoa | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. |
| P16144 | ITGB4 | S1356 | ochoa|psp | Integrin beta-4 (GP150) (CD antigen CD104) | Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
| P18583 | SON | S1076 | ochoa | Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3) | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). {ECO:0000269|PubMed:20581448, ECO:0000269|PubMed:21504830, ECO:0000269|PubMed:27545680}. |
| P21359 | NF1 | S2802 | ochoa | Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated] | Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}. |
| P31629 | HIVEP2 | S71 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P33991 | MCM4 | S88 | ochoa|psp | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:25661590, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}. |
| P42330 | AKR1C3 | S232 | ochoa | Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}. |
| P42768 | WAS | S221 | ochoa | Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) | Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:12769847, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:8625410, ECO:0000269|PubMed:9405671}. |
| P48380 | RFX3 | S155 | ochoa | Transcription factor RFX3 (Regulatory factor X 3) | Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430). {ECO:0000250|UniProtKB:P48381, ECO:0000269|PubMed:12411430, ECO:0000269|PubMed:20148032}. |
| P49790 | NUP153 | S516 | ochoa|psp | Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). {ECO:0000269|PubMed:23523133, ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:29997211}.; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). {ECO:0000269|PubMed:24130490, ECO:0000269|PubMed:31913756}. |
| P49792 | RANBP2 | T896 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P50991 | CCT4 | S381 | ochoa|psp | T-complex protein 1 subunit delta (TCP-1-delta) (EC 3.6.1.-) (CCT-delta) (Chaperonin containing T-complex polypeptide 1 subunit 4) (Stimulator of TAR RNA-binding) | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}. |
| P51825 | AFF1 | S245 | ochoa | AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4) | None |
| P52179 | MYOM1 | S113 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52179 | MYOM1 | S1181 | ochoa | Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1) | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| P52895 | AKR1C2 | S232 | ochoa | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:15929998, PubMed:17034817, PubMed:17442338, PubMed:8573067). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699, ECO:0000269|PubMed:8573067}. |
| P54750 | PDE1A | S487 | ochoa | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) | Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. {ECO:0000269|PubMed:8557689}. |
| P54868 | HMGCS2 | S433 | ochoa | Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}. |
| Q01130 | SRSF2 | S26 | ochoa | Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2) | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. {ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21157427}. |
| Q01167 | FOXK2 | S170 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02078 | MEF2A | S355 | psp | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. {ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15834131, ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:16484498, ECO:0000269|PubMed:16563226, ECO:0000269|PubMed:21468593, ECO:0000269|PubMed:9858528}. |
| Q03188 | CENPC | S73 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q04828 | AKR1C1 | S232 | ochoa | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.357) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1) (DD1) (High-affinity hepatic bile acid-binding protein) (HBAB) | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699). {ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:19218247, ECO:0000269|PubMed:8486699}. |
| Q12802 | AKAP13 | S650 | ochoa | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. |
| Q12923 | PTPN13 | S1359 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q12955 | ANK3 | S1702 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13023 | AKAP6 | S610 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Q13239 | SLA | S190 | ochoa | Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP) | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:10449770, ECO:0000269|PubMed:11696592}. |
| Q13309 | SKP2 | S179 | ochoa | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:9736735, PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1 (By similarity). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22464731, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:9736735, PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731). {ECO:0000250|UniProtKB:Q9Z0Z3, ECO:0000269|PubMed:11931757, ECO:0000269|PubMed:12435635, ECO:0000269|PubMed:12769844, ECO:0000269|PubMed:12840033, ECO:0000269|PubMed:15342634, ECO:0000269|PubMed:15668399, ECO:0000269|PubMed:15949444, ECO:0000269|PubMed:16103164, ECO:0000269|PubMed:16262255, ECO:0000269|PubMed:16581786, ECO:0000269|PubMed:16951159, ECO:0000269|PubMed:17908926, ECO:0000269|PubMed:17962192, ECO:0000269|PubMed:22464731, ECO:0000269|PubMed:22770219, ECO:0000269|PubMed:32267835, ECO:0000269|PubMed:9736735}.; FUNCTION: Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. {ECO:0000269|PubMed:27194766}. |
| Q13905 | RAPGEF1 | S23 | ochoa | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:7806500}. |
| Q14204 | DYNC1H1 | S3082 | ochoa | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}. |
| Q14296 | FASTK | S45 | ochoa | Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8) | Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. {ECO:0000269|PubMed:17135269, ECO:0000269|PubMed:7544399}.; FUNCTION: [Isoform 4]: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. {ECO:0000269|PubMed:25704814}. |
| Q14721 | KCNB1 | S783 | ochoa | Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1) | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216). Plays also a role in the regulation of exocytosis independently of its electrical function (By similarity). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:10484328, PubMed:12560340, PubMed:1283219, PubMed:19074135, PubMed:19717558, PubMed:24901643, PubMed:8081723). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:10484328, PubMed:11852086, PubMed:12060745, PubMed:19074135, PubMed:19717558, PubMed:24901643). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (By similarity). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells. May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (PubMed:12060745). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (By similarity). {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:23161216, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:8081723}. |
| Q14789 | GOLGB1 | S1148 | ochoa | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | May participate in forming intercisternal cross-bridges of the Golgi complex. |
| Q14966 | ZNF638 | S1401 | ochoa | Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein) | Transcription factor that binds to cytidine clusters in double-stranded DNA (PubMed:30487602, PubMed:8647861). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). May also regulate alternative splicing of target genes during adipogenesis (By similarity). {ECO:0000250|UniProtKB:Q61464, ECO:0000269|PubMed:30487602, ECO:0000269|PubMed:8647861}. |
| Q15018 | ABRAXAS2 | S339 | ochoa | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}. |
| Q15561 | TEAD4 | S322 | psp | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q15596 | NCOA2 | S565 | ochoa|psp | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:22504882, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:26553876, ECO:0000269|PubMed:8670870, ECO:0000269|PubMed:9430642}. |
| Q15648 | MED1 | S238 | ochoa | Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}. |
| Q15746 | MYLK | S305 | ochoa | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] | Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis. {ECO:0000269|PubMed:11113114, ECO:0000269|PubMed:11976941, ECO:0000269|PubMed:15020676, ECO:0000269|PubMed:15825080, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:16723733, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18710790, ECO:0000269|PubMed:19826488, ECO:0000269|PubMed:20139351, ECO:0000269|PubMed:20181817, ECO:0000269|PubMed:20375339, ECO:0000269|PubMed:20453870}. |
| Q15788 | NCOA1 | S569 | ochoa|psp | Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}. |
| Q3KR37 | GRAMD1B | S88 | ochoa | Protein Aster-B (GRAM domain-containing protein 1B) | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q80TI0}. |
| Q4J6C6 | PREPL | S410 | ochoa | Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) | Serine peptidase whose precise substrate specificity remains unclear (PubMed:16143824, PubMed:16385448, PubMed:28726805). Does not cleave peptides after a arginine or lysine residue (PubMed:16143824). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (PubMed:24610330). {ECO:0000269|PubMed:16143824, ECO:0000269|PubMed:16385448, ECO:0000269|PubMed:23321636, ECO:0000269|PubMed:24610330, ECO:0000269|PubMed:28726805}. |
| Q53GI3 | ZNF394 | S258 | ochoa | Zinc finger protein 394 (Zinc finger protein with KRAB and SCAN domains 14) | May be involved in transcriptional regulation. |
| Q56NI9 | ESCO2 | S29 | ochoa | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). {ECO:0000269|PubMed:15821733, ECO:0000269|PubMed:15958495, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234}. |
| Q5D1E8 | ZC3H12A | S386 | ochoa | Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) | Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Together with RC3H1, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Self regulates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:22561375, PubMed:26134560, PubMed:26320658). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Also plays a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellular proteins (By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Also induces deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Prevents stress granule (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial pro-inflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q5D1E7, ECO:0000269|PubMed:16574901, ECO:0000269|PubMed:18364357, ECO:0000269|PubMed:19185603, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:22561375, ECO:0000269|PubMed:24048733, ECO:0000269|PubMed:25861989, ECO:0000269|PubMed:26134560, ECO:0000269|PubMed:26320658}.; FUNCTION: (Microbial infection) Binds to Japanese encephalitis virus (JEV) and Dengue virus (DEN) RNAs. {ECO:0000269|PubMed:23355615}.; FUNCTION: (Microbial infection) Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species. {ECO:0000269|PubMed:24191027}. |
| Q5HYI7 | MTX3 | S249 | ochoa | Metaxin-3 | Could function in transport of proteins into the mitochondrion. {ECO:0000250}. |
| Q5JSZ5 | PRRC2B | S1358 | ochoa | Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B) | None |
| Q5SVZ6 | ZMYM1 | S336 | ochoa | Zinc finger MYM-type protein 1 | None |
| Q5T0F9 | CC2D1B | S593 | ochoa | Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2) | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269|PubMed:19423080}. |
| Q5T0W9 | FAM83B | S976 | ochoa | Protein FAM83B | Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades. {ECO:0000269|PubMed:22886302, ECO:0000269|PubMed:23676467, ECO:0000269|PubMed:23912460}. |
| Q5TB80 | CEP162 | S520 | ochoa | Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog) | Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules. {ECO:0000269|PubMed:23644468}. |
| Q5UIP0 | RIF1 | S2265 | ochoa | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:28241136}. |
| Q5VT06 | CEP350 | S567 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VUA4 | ZNF318 | S1856 | ochoa | Zinc finger protein 318 (Endocrine regulatory protein) | [Isoform 2]: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}.; FUNCTION: [Isoform 1]: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. {ECO:0000250|UniProtKB:Q99PP2}. |
| Q5VUJ6 | LRCH2 | S521 | ochoa | Leucine-rich repeat and calponin homology domain-containing protein 2 | May play a role in the organization of the cytoskeleton. {ECO:0000250|UniProtKB:Q960C5, ECO:0000250|UniProtKB:Q96II8}. |
| Q5VV67 | PPRC1 | S1377 | ochoa | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
| Q5VVW2 | GARNL3 | S991 | ochoa | GTPase-activating Rap/Ran-GAP domain-like protein 3 | None |
| Q5VWN6 | TASOR2 | S19 | ochoa | Protein TASOR 2 | None |
| Q5W0B1 | OBI1 | S461 | ochoa | ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). {ECO:0000269|PubMed:31160578}. |
| Q66K14 | TBC1D9B | S463 | ochoa | TBC1 domain family member 9B | May act as a GTPase-activating protein for Rab family protein(s). |
| Q68CQ4 | UTP25 | S273 | ochoa | U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) | Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (PubMed:23357851, PubMed:25007945, PubMed:27657329). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329). {ECO:0000250|UniProtKB:Q6PEH4, ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:25007945, ECO:0000269|PubMed:27657329}. |
| Q6GQQ9 | OTUD7B | S449 | ochoa | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:11463333, PubMed:20622874, PubMed:23827681, PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin (PubMed:12682062). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex (PubMed:28489822). {ECO:0000250|UniProtKB:B2RUR8, ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062, ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:26903241, ECO:0000269|PubMed:27732584, ECO:0000269|PubMed:28489822}. |
| Q6P1L5 | FAM117B | S307 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6P2E9 | EDC4 | S656 | ochoa | Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls) | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
| Q6P4R8 | NFRKB | S228 | ochoa | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. {ECO:0000269|PubMed:18922472}.; FUNCTION: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex. {ECO:0000269|PubMed:18922472}. |
| Q6PEV8 | FAM199X | S323 | ochoa | Protein FAM199X | None |
| Q6PL24 | TMED8 | S153 | ochoa | Protein TMED8 | None |
| Q6T4R5 | NHS | S1499 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6UB98 | ANKRD12 | S1345 | ochoa | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. |
| Q6UB99 | ANKRD11 | S860 | ochoa | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}. |
| Q6UWZ7 | ABRAXAS1 | S387 | ochoa | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538, ECO:0000269|PubMed:26778126}. |
| Q6XZF7 | DNMBP | S1407 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q6ZNJ1 | NBEAL2 | S2208 | ochoa | Neurobeachin-like protein 2 | Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis. {ECO:0000269|PubMed:21765411, ECO:0000269|PubMed:21765412}. |
| Q6ZWJ1 | STXBP4 | S463 | ochoa | Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) | Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}. |
| Q709C8 | VPS13C | S842 | ochoa | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284). {ECO:0000250|UniProtKB:Q07878, ECO:0000269|PubMed:26942284}. |
| Q70SY1 | CREB3L2 | S72 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. |
| Q70SY1 | CREB3L2 | S93 | ochoa | Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) (BBF2 human homolog on chromosome 7) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}. |
| Q711Q0 | CEFIP | S1149 | ochoa | Cardiac-enriched FHL2-interacting protein | Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. {ECO:0000250|UniProtKB:M0RD54}. |
| Q76G19 | PDZD4 | S490 | ochoa | PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein) | None |
| Q7L2J0 | MEPCE | S217 | ochoa | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}. |
| Q7Z2Y5 | NRK | S1149 | ochoa | Nik-related protein kinase (EC 2.7.11.1) | May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity). {ECO:0000250}. |
| Q7Z3J3 | RGPD4 | T897 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z401 | DENND4A | S1282 | ochoa | C-myc promoter-binding protein (DENN domain-containing protein 4A) | Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. {ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:8056341}. |
| Q7Z589 | EMSY | S173 | ochoa | BRCA2-interacting transcriptional repressor EMSY | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}. |
| Q7Z5J4 | RAI1 | S1431 | ochoa | Retinoic acid-induced protein 1 | Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
| Q7Z699 | SPRED1 | S176 | ochoa | Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}. |
| Q7Z6E9 | RBBP6 | S1179 | ochoa | E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:P97868, ECO:0000269|PubMed:18851979, ECO:0000269|PubMed:24726359}.; FUNCTION: (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription. {ECO:0000269|PubMed:30550789}. |
| Q7Z7B0 | FILIP1 | S1005 | ochoa | Filamin-A-interacting protein 1 (FILIP) | By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. {ECO:0000250|UniProtKB:Q8K4T4}. |
| Q7Z7G8 | VPS13B | S3052 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86VQ1 | GLCCI1 | S258 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86W11 | ZSCAN30 | S162 | ochoa | Zinc finger and SCAN domain-containing protein 30 (ZNF-WYM) (Zinc finger protein 397 opposite strand) (Zinc finger protein 397OS) | May be involved in transcriptional regulation. |
| Q86YC2 | PALB2 | S489 | ochoa | Partner and localizer of BRCA2 | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19369211, PubMed:19423707, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair (PubMed:24141787). Essential partner of BRCA2 that promotes the localization and stability of BRCA2 (PubMed:16793542). Also enables its recombinational repair and checkpoint functions of BRCA2 (PubMed:16793542). May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation (PubMed:16793542). Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures (PubMed:20871616). May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (PubMed:24485656). {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:19423707, ECO:0000269|PubMed:20871615, ECO:0000269|PubMed:20871616, ECO:0000269|PubMed:22941656, ECO:0000269|PubMed:24141787, ECO:0000269|PubMed:24485656, ECO:0000269|PubMed:28319063}. |
| Q8IUD2 | ERC1 | S191 | ochoa | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. |
| Q8IV63 | VRK3 | S59 | ochoa | Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3) | Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250|UniProtKB:Q8K3G5, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:19141289, ECO:0000269|PubMed:25899223, ECO:0000269|PubMed:27346674, ECO:0000269|PubMed:27941812}. |
| Q8IWE5 | PLEKHM2 | S264 | ochoa | Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) | Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility (PubMed:22172677, PubMed:24088571, PubMed:25898167, PubMed:28325809). Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). Required for maintenance of the Golgi apparatus organization (PubMed:22172677). May play a role in membrane tubulation (PubMed:15905402). {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:22172677, ECO:0000269|PubMed:24088571, ECO:0000269|PubMed:25898167, ECO:0000269|PubMed:28325809}. |
| Q8IY47 | KBTBD2 | S300 | ochoa | Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. {ECO:0000269|PubMed:27708159}. |
| Q8N3X6 | LCORL | S485 | ochoa | Ligand-dependent nuclear receptor corepressor-like protein (LCoR-like protein) | May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). {ECO:0000250}. |
| Q8N4U5 | TCP11L2 | S55 | ochoa | T-complex protein 11-like protein 2 | Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly. {ECO:0000250|UniProtKB:A7Z033}. |
| Q8N4X5 | AFAP1L2 | S165 | ochoa | Actin filament-associated protein 1-like 2 (AFAP1-like protein 2) | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. {ECO:0000269|PubMed:17412687}. |
| Q8N8K9 | KIAA1958 | S272 | ochoa | Uncharacterized protein KIAA1958 | None |
| Q8NCE2 | MTMR14 | S624 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 (EC 3.1.3.95) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (Myotubularin-related protein 14) (Phosphatidylinositol-3-phosphate phosphatase) (hJumpy) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. {ECO:0000269|PubMed:17008356}. |
| Q8NDV7 | TNRC6A | S672 | ochoa | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}. |
| Q8NEM0 | MCPH1 | S277 | ochoa | Microcephalin | Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. {ECO:0000269|PubMed:12046007, ECO:0000269|PubMed:15199523, ECO:0000269|PubMed:15220350}. |
| Q8NEV8 | EXPH5 | S643 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NEY1 | NAV1 | S1405 | ochoa | Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1) | May be involved in neuronal migration. {ECO:0000250}. |
| Q8NG08 | HELB | S1048 | ochoa | DNA helicase B (hDHB) (EC 3.6.4.12) | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613, ECO:0000269|PubMed:25617833, ECO:0000269|PubMed:26774285}. |
| Q8NG27 | PJA1 | S70 | ochoa | E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1) | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269|PubMed:12036302}. |
| Q8NG31 | KNL1 | S1076 | ochoa | Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14) | Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250|UniProtKB:Q66JQ7, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986, ECO:0000269|PubMed:19893618, ECO:0000269|PubMed:21199919, ECO:0000269|PubMed:22000412, ECO:0000269|PubMed:22331848, ECO:0000269|PubMed:25308863, ECO:0000269|PubMed:27881301, ECO:0000269|PubMed:30100357, ECO:0000269|PubMed:38459127, ECO:0000269|PubMed:38459128}. |
| Q8TDD1 | DDX54 | S173 | ochoa | ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54) | Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors. {ECO:0000269|PubMed:12466272}. |
| Q8WUY3 | PRUNE2 | S1639 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WUY3 | PRUNE2 | S2211 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q8WVV9 | HNRNPLL | S426 | ochoa | Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor) | RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
| Q92613 | JADE3 | S695 | ochoa | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269|PubMed:16387653}. |
| Q92692 | NECTIN2 | S433 | ochoa | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}. |
| Q92870 | APBB2 | S31 | ochoa | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP (PubMed:14527950). {ECO:0000250|UniProtKB:Q9DBR4, ECO:0000269|PubMed:14527950}. |
| Q969F2 | NKD2 | S176 | ochoa | Protein naked cuticle homolog 2 (Naked-2) (hNkd2) | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. |
| Q96JM2 | ZNF462 | S2172 | ochoa | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). {ECO:0000250|UniProtKB:B1AWL2, ECO:0000269|PubMed:20219459, ECO:0000269|PubMed:21570965}. |
| Q96K83 | ZNF521 | S1179 | ochoa | Zinc finger protein 521 (Early hematopoietic zinc finger protein) (LYST-interacting protein 3) | Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}. |
| Q96MU7 | YTHDC1 | S77 | ochoa | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518). Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306). Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). {ECO:0000250|UniProtKB:E9Q5K9, ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32663306}. |
| Q96P20 | NLRP3 | S728 | psp | NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) | Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:23582325, PubMed:25686105, PubMed:27929086, PubMed:28656979, PubMed:28847925, PubMed:30487600, PubMed:30612879, PubMed:31086327, PubMed:31086329, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:34512673, PubMed:36442502). In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC (PubMed:16407889, PubMed:18403674, PubMed:27432880, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353, PubMed:36142182, PubMed:36442502). Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis (PubMed:23582325, PubMed:28847925, PubMed:31189953, PubMed:33231615, PubMed:34133077, PubMed:34341353). Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (PubMed:22801494). Under resting conditions, ADP-bound NLRP3 is autoinhibited (PubMed:35114687). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc (PubMed:16407889, PubMed:18403674, PubMed:18604214, PubMed:19414800, PubMed:23871209). Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex (PubMed:36442502, PubMed:39173637). Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) (PubMed:30487600, PubMed:34554188). Shows ATPase activity (PubMed:17483456). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:16407889, ECO:0000269|PubMed:17483456, ECO:0000269|PubMed:18403674, ECO:0000269|PubMed:18604214, ECO:0000269|PubMed:19414800, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23582325, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:25686105, ECO:0000269|PubMed:27432880, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:28656979, ECO:0000269|PubMed:28847925, ECO:0000269|PubMed:30487600, ECO:0000269|PubMed:30612879, ECO:0000269|PubMed:31086327, ECO:0000269|PubMed:31086329, ECO:0000269|PubMed:31189953, ECO:0000269|PubMed:33231615, ECO:0000269|PubMed:34133077, ECO:0000269|PubMed:34341353, ECO:0000269|PubMed:34554188, ECO:0000269|PubMed:35114687, ECO:0000269|PubMed:36142182, ECO:0000269|PubMed:36442502, ECO:0000269|PubMed:39173637}.; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8}. |
| Q96QB1 | DLC1 | S946 | ochoa|psp | Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12) | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (PubMed:26166433). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (PubMed:26166433). {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422, ECO:0000269|PubMed:26166433}. |
| Q96QS3 | ARX | S67 | ochoa|psp | Homeobox protein ARX (Aristaless-related homeobox) | Transcription factor (PubMed:22194193, PubMed:31691806). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C (PubMed:22194193, PubMed:31691806). Positively modulates transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (PubMed:31691806). Required for normal brain development (PubMed:11889467, PubMed:12379852, PubMed:14722918). Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (By similarity). May also be involved in axonal guidance in the floor plate (By similarity). {ECO:0000250|UniProtKB:O35085, ECO:0000269|PubMed:11889467, ECO:0000269|PubMed:12379852, ECO:0000269|PubMed:14722918, ECO:0000269|PubMed:22194193, ECO:0000269|PubMed:31691806}. |
| Q96S38 | RPS6KC1 | S560 | ochoa | Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) | May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell (PubMed:12077123). Plays a role in the recruitment of PRDX3 to early endosomes (PubMed:15750338). {ECO:0000269|PubMed:12077123, ECO:0000269|PubMed:15750338}. |
| Q96S66 | CLCC1 | S509 | ochoa | Chloride channel CLIC-like protein 1 (ER anion channel 1) (ERAC1) (Mid-1-related chloride channel protein) | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673). {ECO:0000250|UniProtKB:Q99LI2, ECO:0000269|PubMed:25698737, ECO:0000269|PubMed:30157172, ECO:0000269|PubMed:37142673}. |
| Q96SK2 | TMEM209 | S228 | ochoa | Transmembrane protein 209 | Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC. {ECO:0000269|PubMed:22719065}. |
| Q96ST2 | IWS1 | S621 | ochoa | Protein IWS1 homolog (IWS1-like protein) | Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}. |
| Q96T58 | SPEN | S2101 | ochoa | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250|UniProtKB:Q62504, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}. |
| Q99666 | RGPD5 | T896 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BUG6 | ZSCAN5A | S296 | ochoa | Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495) | May be involved in transcriptional regulation. |
| Q9BW91 | NUDT9 | S68 | ochoa | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
| Q9BWT3 | PAPOLG | S23 | ochoa | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11463842}. |
| Q9BX63 | BRIP1 | S930 | ochoa | Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ) | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400). {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896, ECO:0000269|PubMed:17596542, ECO:0000269|PubMed:18426915, ECO:0000269|PubMed:20639400, ECO:0000269|PubMed:36608669}. |
| Q9BXL6 | CARD14 | S475 | ochoa | Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2) | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:27071417, ECO:0000269|PubMed:27113748}.; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359). {ECO:0000269|PubMed:21302310, ECO:0000269|PubMed:26358359}. |
| Q9BY12 | SCAPER | S86 | ochoa | S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) | CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}. |
| Q9BY77 | POLDIP3 | S368 | ochoa | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex. {ECO:0000269|PubMed:18423201, ECO:0000269|PubMed:22928037}. |
| Q9BZ95 | NSD3 | S107 | ochoa | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1) | Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}. |
| Q9C0A6 | SETD5 | S829 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0A6 | SETD5 | S1198 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0A6 | SETD5 | S1233 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0A6 | SETD5 | S1269 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9C0C6 | CIPC | S302 | ochoa | CLOCK-interacting pacemaker (CLOCK-interacting circadian protein) | Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock. {ECO:0000250|UniProtKB:Q8R0W1}. |
| Q9GZY8 | MFF | S21 | ochoa | Mitochondrial fission factor | Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250|UniProtKB:Q4KM98, ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}. |
| Q9H4B7 | TUBB1 | S89 | ochoa | Tubulin beta-1 chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Q9H5I1 | SUV39H2 | S388 | ochoa | Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126}. |
| Q9H5J8 | TAF1D | S40 | ochoa | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}. |
| Q9H6Q4 | CIAO3 | S214 | ochoa | Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Protein related to Narf) | Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}. |
| Q9HAW0 | BRF2 | S353 | ochoa | Transcription factor IIIB 50 kDa subunit (TFIIIB50) (hTFIIIB50) (B-related factor 2) (BRF-2) (hBRFU) | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}. |
| Q9HCI7 | MSL2 | S551 | ochoa | E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.27) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184) | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). MSL2 plays a key role in gene dosage by ensuring biallelic expression of a subset of dosage-sensitive genes, including many haploinsufficient genes (By similarity). Acts by promoting promoter-enhancer contacts, thereby preventing DNA methylation of one allele and creating a methylation-free environment for methylation-sensitive transcription factors such as SP1, KANSL1 and KANSL3 (By similarity). Also acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A (PubMed:21726816, PubMed:30930284). This activity is greatly enhanced by heterodimerization with MSL1 (PubMed:21726816, PubMed:30930284). H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). Also involved in the DNA damage response by mediating ubiquitination of TP53/p53 and TP53BP1 (PubMed:19033443, PubMed:23874665). {ECO:0000250|UniProtKB:Q69ZF8, ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:16543150, ECO:0000269|PubMed:19033443, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:23874665, ECO:0000269|PubMed:30930284, ECO:0000269|PubMed:33837287}. |
| Q9HCM1 | RESF1 | S1208 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
| Q9HCM4 | EPB41L5 | S517 | ochoa | Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5) | Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}. |
| Q9NPI6 | DCP1A | S525 | ochoa | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}. |
| Q9NS56 | TOPORS | S98 | ochoa|psp | E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}. |
| Q9NUY8 | TBC1D23 | S474 | ochoa | TBC1 domain family member 23 (HCV non-structural protein 4A-transactivated protein 1) | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707). Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity). {ECO:0000250|UniProtKB:Q8K0F1, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197, ECO:0000269|PubMed:29426865}. |
| Q9NX31 | OSER1 | S114 | ochoa | Oxidative stress-responsive serine-rich protein 1 (Oxidative stress-responsive protein 1) (Peroxide-inducible transcript 1 protein) | None |
| Q9NYA4 | MTMR4 | S1002 | ochoa | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (EC 3.1.3.95) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Myotubularin-related protein 4) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (Zinc finger FYVE domain-containing protein 11) | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675). {ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:20061380, ECO:0000269|PubMed:20736309, ECO:0000269|PubMed:23150675, ECO:0000269|PubMed:25659891, ECO:0000269|PubMed:27625994, ECO:0000269|PubMed:29962048, ECO:0000269|PubMed:30944173, ECO:0000269|PubMed:31543504}. |
| Q9NZC9 | SMARCAL1 | S151 | ochoa | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1) | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. {ECO:0000269|PubMed:18805831, ECO:0000269|PubMed:18974355, ECO:0000269|PubMed:19793861, ECO:0000269|PubMed:19793862}. |
| Q9P266 | JCAD | S757 | ochoa | Junctional cadherin 5-associated protein (Junctional protein associated with coronary artery disease) (JCAD) | None |
| Q9P275 | USP36 | S464 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P275 | USP36 | S582 | ochoa | Ubiquitin carboxyl-terminal hydrolase 36 (EC 2.3.2.-) (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) | Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080). {ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:21268071, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:22902402, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:29273634, ECO:0000269|PubMed:29274341, ECO:0000269|PubMed:35989368, ECO:0000269|PubMed:36912080}. |
| Q9P2H5 | USP35 | S982 | ochoa | Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) | Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed:26348204, PubMed:29449677, PubMed:37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed:26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed:29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed:34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed:25915564). {ECO:0000269|PubMed:25915564, ECO:0000269|PubMed:26348204, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:34438346, ECO:0000269|PubMed:37004621}. |
| Q9P2K1 | CC2D2A | S1085 | ochoa | Coiled-coil and C2 domain-containing protein 2A | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:18513680}. |
| Q9UJ78 | ZMYM5 | S218 | ochoa | Zinc finger MYM-type protein 5 (Zinc finger protein 198-like 1) (Zinc finger protein 237) | Functions as a transcriptional regulator. {ECO:0000269|PubMed:17126306}. |
| Q9ULD9 | ZNF608 | S1402 | ochoa | Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) | Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}. |
| Q9ULH1 | ASAP1 | S525 | ochoa | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879). {ECO:0000250, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:25673879}. |
| Q9ULV3 | CIZ1 | S783 | ochoa | Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356) | May regulate the subcellular localization of CIP/WAF1. |
| Q9UPQ4 | TRIM35 | S65 | ochoa | E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5) | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:25907537, ECO:0000269|PubMed:32562145}. |
| Q9UPQ9 | TNRC6B | S1570 | ochoa | Trinucleotide repeat-containing gene 6B protein | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923). {ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:19167051, ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:32354837}. |
| Q9UPU7 | TBC1D2B | S155 | ochoa | TBC1 domain family member 2B | GTPase-activating protein that plays a role in the early steps of endocytosis (PubMed:32623794). {ECO:0000269|PubMed:32623794}. |
| Q9UQ84 | EXO1 | S598 | ochoa | Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI) | 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. {ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837, ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105, ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184, ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842, ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194, ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
| Q9Y232 | CDYL | S149 | ochoa | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) | [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (PubMed:29177481). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (By similarity). In addition to acting as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000269|PubMed:19061646, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:22009739, ECO:0000269|PubMed:28402439, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:29177481}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain (PubMed:19808672). {ECO:0000269|PubMed:19808672}.; FUNCTION: [Isoform 3]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin. {ECO:0000269|PubMed:19808672}. |
| Q9Y285 | FARSA | S193 | ochoa | Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) | None |
| Q9Y2I6 | NINL | S191 | ochoa | Ninein-like protein | Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}. |
| Q9Y4B5 | MTCL1 | S1656 | ochoa | Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) | Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269|PubMed:23902687, ECO:0000269|PubMed:33587225}. |
| Q9Y580 | RBM7 | S137 | ochoa | RNA-binding protein 7 (RNA-binding motif protein 7) | RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104, PubMed:27871484). NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:25189701, PubMed:25852104, PubMed:27871484). Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) (PubMed:25189701, PubMed:25525152, PubMed:25578728, PubMed:25852104). Participates in several biological processes including DNA damage response (DDR) and stress response (PubMed:25525152, PubMed:30824372). During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome (PubMed:25525152). Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability (PubMed:30824372). {ECO:0000269|PubMed:25189701, ECO:0000269|PubMed:25525152, ECO:0000269|PubMed:25578728, ECO:0000269|PubMed:25852104, ECO:0000269|PubMed:27871484, ECO:0000269|PubMed:30824372}. |
| Q9Y5T4 | DNAJC15 | S104 | ochoa | DnaJ homolog subfamily C member 15 (Cell growth-inhibiting gene 22 protein) (Methylation-controlled J protein) (MCJ) | Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. {ECO:0000250, ECO:0000269|PubMed:23263864}. |
| Q9Y6I4 | USP3 | S37 | ochoa | Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) | Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites (PubMed:24196443). Required for proper progression through S phase and subsequent mitotic entry (PubMed:17980597). Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation (PubMed:28807825). Participates in establishing tolerance innate immune memory through non-transcriptional feedback. Mechanistically, negatively regulates TLR-induced NF-kappa-B signaling by targeting and removing the 'Lys-63'-linked polyubiquitin chains on MYD88 (PubMed:37971847). Negatively regulates the activation of type I interferon signaling by mediating 'Lys-63'-linked polyubiquitin chains on RIGI and IFIH1 (PubMed:24366338). Also deubiquinates ASC/PYCARD, the central adapter mediating the assembly and activation of most inflammasomes, and thereby promotes inflammasome activation (PubMed:36050480). {ECO:0000269|PubMed:17980597, ECO:0000269|PubMed:24196443, ECO:0000269|PubMed:24366338, ECO:0000269|PubMed:28807825, ECO:0000269|PubMed:36050480, ECO:0000269|PubMed:37971847}. |
| Q9Y6Q9 | NCOA3 | S640 | ochoa | Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Q01196 | RUNX1 | S397 | SIGNOR | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q03347, ECO:0000269|PubMed:10207087, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:14970218, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:17431401, ECO:0000305}.; FUNCTION: Isoform AML-1G shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000250|UniProtKB:Q03347}.; FUNCTION: Isoform AML-1L interferes with the transactivation activity of RUNX1. {ECO:0000269|PubMed:9199349}. |
| P24752 | ACAT1 | S69 | Sugiyama | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2) | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475). {ECO:0000269|PubMed:1715688, ECO:0000269|PubMed:17371050, ECO:0000269|PubMed:7728148, ECO:0000269|PubMed:9744475}. |
| Q08289 | CACNB2 | S495 | EPSD | Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). {ECO:0000250|UniProtKB:Q8CC27, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:17525370, ECO:0000269|PubMed:36424916}. |
| P19525 | EIF2AK2 | S418 | Sugiyama | Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) | IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19189853, PubMed:19507191, PubMed:21072047, PubMed:21123651, PubMed:22381929, PubMed:22948139, PubMed:23229543). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:19840259, PubMed:20171114, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:19229320, PubMed:22214662). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}. |
| O14929 | HAT1 | S361 | Sugiyama | Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) | Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:23653357, ECO:0000269|PubMed:31278053, ECO:0000269|PubMed:31812350, ECO:0000269|PubMed:32081014}.; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. {ECO:0000269|PubMed:31695772}. |
| Q15078 | CDK5R1 | S135 | Sugiyama | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-383280 | Nuclear Receptor transcription pathway | 0.000001 | 5.967 |
| R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | 0.000170 | 3.770 |
| R-HSA-5635851 | GLI proteins bind promoters of Hh responsive genes to promote transcription | 0.000271 | 3.566 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.000762 | 3.118 |
| R-HSA-432030 | Transport of glycerol from adipocytes to the liver by Aquaporins | 0.001007 | 2.997 |
| R-HSA-8951911 | RUNX3 regulates RUNX1-mediated transcription | 0.001772 | 2.752 |
| R-HSA-8934593 | Regulation of RUNX1 Expression and Activity | 0.001562 | 2.806 |
| R-HSA-1989781 | PPARA activates gene expression | 0.001498 | 2.824 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.001619 | 2.791 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.002386 | 2.622 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.002385 | 2.623 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.002626 | 2.581 |
| R-HSA-9634815 | Transcriptional Regulation by NPAS4 | 0.002424 | 2.615 |
| R-HSA-9709603 | Impaired BRCA2 binding to PALB2 | 0.006130 | 2.213 |
| R-HSA-9701193 | Defective homologous recombination repair (HRR) due to PALB2 loss of function | 0.006852 | 2.164 |
| R-HSA-9704646 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.006852 | 2.164 |
| R-HSA-9704331 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of... | 0.006852 | 2.164 |
| R-HSA-9701192 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function | 0.006852 | 2.164 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.006340 | 2.198 |
| R-HSA-426496 | Post-transcriptional silencing by small RNAs | 0.005266 | 2.279 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.006340 | 2.198 |
| R-HSA-9707616 | Heme signaling | 0.004640 | 2.334 |
| R-HSA-9768759 | Regulation of NPAS4 gene expression | 0.004827 | 2.316 |
| R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | 0.006166 | 2.210 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.008533 | 2.069 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.008533 | 2.069 |
| R-HSA-9648895 | Response of EIF2AK1 (HRI) to heme deficiency | 0.010233 | 1.990 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.011152 | 1.953 |
| R-HSA-9768778 | Regulation of NPAS4 mRNA translation | 0.012496 | 1.903 |
| R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SD... | 0.012227 | 1.913 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.012254 | 1.912 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.013302 | 1.876 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.013368 | 1.874 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.015165 | 1.819 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.015165 | 1.819 |
| R-HSA-5617833 | Cilium Assembly | 0.015606 | 1.807 |
| R-HSA-9759811 | Regulation of CDH11 mRNA translation by microRNAs | 0.019648 | 1.707 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.018507 | 1.733 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.028126 | 1.551 |
| R-HSA-5693537 | Resolution of D-Loop Structures | 0.023797 | 1.623 |
| R-HSA-9843745 | Adipogenesis | 0.026060 | 1.584 |
| R-HSA-9930044 | Nuclear RNA decay | 0.022299 | 1.652 |
| R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | 0.022299 | 1.652 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.028410 | 1.547 |
| R-HSA-5610787 | Hedgehog 'off' state | 0.028410 | 1.547 |
| R-HSA-9675136 | Diseases of DNA Double-Strand Break Repair | 0.025348 | 1.596 |
| R-HSA-169131 | Inhibition of PKR | 0.029973 | 1.523 |
| R-HSA-9701190 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function | 0.025348 | 1.596 |
| R-HSA-3214847 | HATs acetylate histones | 0.027478 | 1.561 |
| R-HSA-9029569 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflu... | 0.018991 | 1.721 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.018109 | 1.742 |
| R-HSA-9022692 | Regulation of MECP2 expression and activity | 0.022299 | 1.652 |
| R-HSA-9764260 | Regulation of Expression and Function of Type II Classical Cadherins | 0.022299 | 1.652 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of lig... | 0.029749 | 1.527 |
| R-HSA-9909396 | Circadian clock | 0.026812 | 1.572 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.025675 | 1.590 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.027809 | 1.556 |
| R-HSA-192105 | Synthesis of bile acids and bile salts | 0.027478 | 1.561 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.016969 | 1.770 |
| R-HSA-8941326 | RUNX2 regulates bone development | 0.028610 | 1.543 |
| R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | 0.026953 | 1.569 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.025348 | 1.596 |
| R-HSA-9764562 | Regulation of CDH1 mRNA translation by microRNAs | 0.031224 | 1.506 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.031224 | 1.506 |
| R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation | 0.034449 | 1.463 |
| R-HSA-9823739 | Formation of the anterior neural plate | 0.034449 | 1.463 |
| R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 0.032084 | 1.494 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.033899 | 1.470 |
| R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) | 0.034882 | 1.457 |
| R-HSA-9646399 | Aggrephagy | 0.035767 | 1.447 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.036241 | 1.441 |
| R-HSA-9915355 | Beta-ketothiolase deficiency | 0.044622 | 1.350 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.101047 | 0.995 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.101047 | 0.995 |
| R-HSA-8935964 | RUNX1 regulates expression of components of tight junctions | 0.114627 | 0.941 |
| R-HSA-111957 | Cam-PDE 1 activation | 0.114627 | 0.941 |
| R-HSA-9022537 | Loss of MECP2 binding ability to the NCoR/SMRT complex | 0.114627 | 0.941 |
| R-HSA-8939256 | RUNX1 regulates transcription of genes involved in WNT signaling | 0.128003 | 0.893 |
| R-HSA-8939246 | RUNX1 regulates transcription of genes involved in differentiation of myeloid ce... | 0.154153 | 0.812 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.154153 | 0.812 |
| R-HSA-9909620 | Regulation of PD-L1(CD274) translation | 0.056241 | 1.250 |
| R-HSA-390450 | Folding of actin by CCT/TriC | 0.179523 | 0.746 |
| R-HSA-112308 | Presynaptic depolarization and calcium channel opening | 0.191922 | 0.717 |
| R-HSA-8943723 | Regulation of PTEN mRNA translation | 0.072791 | 1.138 |
| R-HSA-389957 | Prefoldin mediated transfer of substrate to CCT/TriC | 0.072791 | 1.138 |
| R-HSA-389960 | Formation of tubulin folding intermediates by CCT/TriC | 0.077147 | 1.113 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.090680 | 1.042 |
| R-HSA-8877330 | RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) | 0.228010 | 0.642 |
| R-HSA-9709570 | Impaired BRCA2 binding to RAD51 | 0.100059 | 1.000 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.104846 | 0.979 |
| R-HSA-389958 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | 0.109693 | 0.960 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.109693 | 0.960 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.109693 | 0.960 |
| R-HSA-9027284 | Erythropoietin activates RAS | 0.251173 | 0.600 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.119560 | 0.922 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.119560 | 0.922 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.124574 | 0.905 |
| R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis | 0.124574 | 0.905 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.262493 | 0.581 |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | 0.262493 | 0.581 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.134747 | 0.870 |
| R-HSA-5655862 | Translesion synthesis by POLK | 0.273643 | 0.563 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.049827 | 1.303 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.155610 | 0.808 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.160919 | 0.793 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.095232 | 1.021 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.095232 | 1.021 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.062079 | 1.207 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.104435 | 0.981 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.110758 | 0.956 |
| R-HSA-774815 | Nucleosome assembly | 0.193385 | 0.714 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.193385 | 0.714 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.127180 | 0.896 |
| R-HSA-380287 | Centrosome maturation | 0.133979 | 0.873 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.221022 | 0.656 |
| R-HSA-72187 | mRNA 3'-end processing | 0.232171 | 0.634 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.304754 | 0.516 |
| R-HSA-8931987 | RUNX1 regulates estrogen receptor mediated transcription | 0.141177 | 0.850 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.064315 | 1.192 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.064315 | 1.192 |
| R-HSA-390466 | Chaperonin-mediated protein folding | 0.180928 | 0.742 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.064315 | 1.192 |
| R-HSA-5620916 | VxPx cargo-targeting to cilium | 0.316589 | 0.500 |
| R-HSA-391251 | Protein folding | 0.203921 | 0.691 |
| R-HSA-432047 | Passive transport by Aquaporins | 0.041265 | 1.384 |
| R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocy... | 0.154153 | 0.812 |
| R-HSA-9668328 | Sealing of the nuclear envelope (NE) by ESCRT-III | 0.119560 | 0.922 |
| R-HSA-8849473 | PTK6 Expression | 0.141177 | 0.850 |
| R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 0.119560 | 0.922 |
| R-HSA-5576893 | Phase 2 - plateau phase | 0.273643 | 0.563 |
| R-HSA-389977 | Post-chaperonin tubulin folding pathway | 0.316589 | 0.500 |
| R-HSA-399956 | CRMPs in Sema3A signaling | 0.239679 | 0.620 |
| R-HSA-110312 | Translesion synthesis by REV1 | 0.251173 | 0.600 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.123828 | 0.907 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.267229 | 0.573 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.155096 | 0.809 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.127488 | 0.895 |
| R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 0.107578 | 0.968 |
| R-HSA-111446 | Activation of BIM and translocation to mitochondria | 0.073262 | 1.135 |
| R-HSA-8941333 | RUNX2 regulates genes involved in differentiation of myeloid cells | 0.087260 | 1.059 |
| R-HSA-9032845 | Activated NTRK2 signals through CDK5 | 0.141177 | 0.850 |
| R-HSA-176974 | Unwinding of DNA | 0.166934 | 0.777 |
| R-HSA-2468052 | Establishment of Sister Chromatid Cohesion | 0.179523 | 0.746 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.191922 | 0.717 |
| R-HSA-202670 | ERKs are inactivated | 0.204134 | 0.690 |
| R-HSA-9839394 | TGFBR3 expression | 0.081582 | 1.088 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.145099 | 0.838 |
| R-HSA-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | 0.284625 | 0.546 |
| R-HSA-181429 | Serotonin Neurotransmitter Release Cycle | 0.295442 | 0.530 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.193385 | 0.714 |
| R-HSA-5620924 | Intraflagellar transport | 0.209920 | 0.678 |
| R-HSA-68949 | Orc1 removal from chromatin | 0.232171 | 0.634 |
| R-HSA-5693538 | Homology Directed Repair | 0.143639 | 0.843 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.123915 | 0.907 |
| R-HSA-5632684 | Hedgehog 'on' state | 0.120509 | 0.919 |
| R-HSA-844456 | The NLRP3 inflammasome | 0.052339 | 1.281 |
| R-HSA-5358351 | Signaling by Hedgehog | 0.089737 | 1.047 |
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | 0.196180 | 0.707 |
| R-HSA-9764302 | Regulation of CDH19 Expression and Function | 0.114627 | 0.941 |
| R-HSA-8875555 | MET activates RAP1 and RAC1 | 0.179523 | 0.746 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.124574 | 0.905 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.120509 | 0.919 |
| R-HSA-9708530 | Regulation of BACH1 activity | 0.037798 | 1.423 |
| R-HSA-913531 | Interferon Signaling | 0.165709 | 0.781 |
| R-HSA-68877 | Mitotic Prometaphase | 0.045046 | 1.346 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.288195 | 0.540 |
| R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 | 0.087260 | 1.059 |
| R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease | 0.041265 | 1.384 |
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | 0.048540 | 1.314 |
| R-HSA-9832991 | Formation of the posterior neural plate | 0.191922 | 0.717 |
| R-HSA-77108 | Utilization of Ketone Bodies | 0.191922 | 0.717 |
| R-HSA-9623433 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis | 0.204134 | 0.690 |
| R-HSA-190872 | Transport of connexons to the plasma membrane | 0.295442 | 0.530 |
| R-HSA-264642 | Acetylcholine Neurotransmitter Release Cycle | 0.326925 | 0.486 |
| R-HSA-5357786 | TNFR1-induced proapoptotic signaling | 0.326925 | 0.486 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.166022 | 0.780 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.271383 | 0.566 |
| R-HSA-191859 | snRNP Assembly | 0.271383 | 0.566 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.282595 | 0.549 |
| R-HSA-9609690 | HCMV Early Events | 0.112296 | 0.950 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.269136 | 0.570 |
| R-HSA-445717 | Aquaporin-mediated transport | 0.282595 | 0.549 |
| R-HSA-1912422 | Pre-NOTCH Expression and Processing | 0.296666 | 0.528 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.121756 | 0.915 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.209920 | 0.678 |
| R-HSA-2028269 | Signaling by Hippo | 0.284625 | 0.546 |
| R-HSA-198753 | ERK/MAPK targets | 0.060240 | 1.220 |
| R-HSA-622312 | Inflammasomes | 0.095336 | 1.021 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.129637 | 0.887 |
| R-HSA-6811436 | COPI-independent Golgi-to-ER retrograde traffic | 0.072471 | 1.140 |
| R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | 0.134747 | 0.870 |
| R-HSA-1660517 | Synthesis of PIPs at the late endosome membrane | 0.284625 | 0.546 |
| R-HSA-74182 | Ketone body metabolism | 0.072791 | 1.138 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.166260 | 0.779 |
| R-HSA-9660826 | Purinergic signaling in leishmaniasis infection | 0.198879 | 0.701 |
| R-HSA-9664424 | Cell recruitment (pro-inflammatory response) | 0.198879 | 0.701 |
| R-HSA-8941284 | RUNX2 regulates chondrocyte maturation | 0.101047 | 0.995 |
| R-HSA-77111 | Synthesis of Ketone Bodies | 0.056241 | 1.250 |
| R-HSA-8951936 | RUNX3 regulates p14-ARF | 0.216163 | 0.665 |
| R-HSA-418457 | cGMP effects | 0.239679 | 0.620 |
| R-HSA-9837092 | FASTK family proteins regulate processing and stability of mitochondrial RNAs | 0.251173 | 0.600 |
| R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA | 0.251173 | 0.600 |
| R-HSA-9024446 | NR1H2 and NR1H3-mediated signaling | 0.041977 | 1.377 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.160919 | 0.793 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.160919 | 0.793 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.166260 | 0.779 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.130564 | 0.884 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.061365 | 1.212 |
| R-HSA-73856 | RNA Polymerase II Transcription Termination | 0.282595 | 0.549 |
| R-HSA-5358508 | Mismatch Repair | 0.295442 | 0.530 |
| R-HSA-9768777 | Regulation of NPAS4 gene transcription | 0.166934 | 0.777 |
| R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) | 0.284625 | 0.546 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.051299 | 1.290 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.190223 | 0.721 |
| R-HSA-8939211 | ESR-mediated signaling | 0.044586 | 1.351 |
| R-HSA-68882 | Mitotic Anaphase | 0.071042 | 1.148 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.124574 | 0.905 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.247602 | 0.606 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.072285 | 1.141 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.232171 | 0.634 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.070142 | 1.154 |
| R-HSA-74160 | Gene expression (Transcription) | 0.083487 | 1.078 |
| R-HSA-69481 | G2/M Checkpoints | 0.172207 | 0.764 |
| R-HSA-9824594 | Regulation of MITF-M-dependent genes involved in apoptosis | 0.060240 | 1.220 |
| R-HSA-9005891 | Loss of function of MECP2 in Rett syndrome | 0.216163 | 0.665 |
| R-HSA-9005895 | Pervasive developmental disorders | 0.216163 | 0.665 |
| R-HSA-9697154 | Disorders of Nervous System Development | 0.216163 | 0.665 |
| R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) | 0.284625 | 0.546 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.150336 | 0.823 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.316589 | 0.500 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.198879 | 0.701 |
| R-HSA-68886 | M Phase | 0.090602 | 1.043 |
| R-HSA-9609646 | HCMV Infection | 0.230740 | 0.637 |
| R-HSA-212436 | Generic Transcription Pathway | 0.283507 | 0.547 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.235959 | 0.627 |
| R-HSA-8874211 | CREB3 factors activate genes | 0.128003 | 0.893 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.133979 | 0.873 |
| R-HSA-69275 | G2/M Transition | 0.204121 | 0.690 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.209464 | 0.679 |
| R-HSA-9839373 | Signaling by TGFBR3 | 0.198879 | 0.701 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.299382 | 0.524 |
| R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | 0.251173 | 0.600 |
| R-HSA-9706369 | Negative regulation of FLT3 | 0.262493 | 0.581 |
| R-HSA-388844 | Receptor-type tyrosine-protein phosphatases | 0.262493 | 0.581 |
| R-HSA-9675151 | Disorders of Developmental Biology | 0.273643 | 0.563 |
| R-HSA-549127 | SLC-mediated transport of organic cations | 0.145099 | 0.838 |
| R-HSA-73894 | DNA Repair | 0.224590 | 0.649 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.066753 | 1.176 |
| R-HSA-2559585 | Oncogene Induced Senescence | 0.134747 | 0.870 |
| R-HSA-446728 | Cell junction organization | 0.087473 | 1.058 |
| R-HSA-170968 | Frs2-mediated activation | 0.228010 | 0.642 |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | 0.166260 | 0.779 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.041856 | 1.378 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.260166 | 0.585 |
| R-HSA-1640170 | Cell Cycle | 0.055046 | 1.259 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.169714 | 0.770 |
| R-HSA-9675135 | Diseases of DNA repair | 0.050282 | 1.299 |
| R-HSA-2173788 | Downregulation of TGF-beta receptor signaling | 0.068519 | 1.164 |
| R-HSA-525793 | Myogenesis | 0.086094 | 1.065 |
| R-HSA-9759475 | Regulation of CDH11 Expression and Function | 0.100059 | 1.000 |
| R-HSA-912631 | Regulation of signaling by CBL | 0.306096 | 0.514 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.237759 | 0.624 |
| R-HSA-983189 | Kinesins | 0.276990 | 0.558 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.288195 | 0.540 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.042142 | 1.375 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.282595 | 0.549 |
| R-HSA-1500931 | Cell-Cell communication | 0.143158 | 0.844 |
| R-HSA-418990 | Adherens junctions interactions | 0.073541 | 1.133 |
| R-HSA-421270 | Cell-cell junction organization | 0.122130 | 0.913 |
| R-HSA-420597 | Nectin/Necl trans heterodimerization | 0.101047 | 0.995 |
| R-HSA-110357 | Displacement of DNA glycosylase by APEX1 | 0.141177 | 0.850 |
| R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases | 0.100059 | 1.000 |
| R-HSA-211000 | Gene Silencing by RNA | 0.109691 | 0.960 |
| R-HSA-5687128 | MAPK6/MAPK4 signaling | 0.169714 | 0.770 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.112296 | 0.950 |
| R-HSA-159418 | Recycling of bile acids and salts | 0.119560 | 0.922 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.326925 | 0.486 |
| R-HSA-5688426 | Deubiquitination | 0.061208 | 1.213 |
| R-HSA-2132295 | MHC class II antigen presentation | 0.157680 | 0.802 |
| R-HSA-4839726 | Chromatin organization | 0.055290 | 1.257 |
| R-HSA-194068 | Bile acid and bile salt metabolism | 0.039979 | 1.398 |
| R-HSA-211976 | Endogenous sterols | 0.282595 | 0.549 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.310539 | 0.508 |
| R-HSA-373760 | L1CAM interactions | 0.317314 | 0.499 |
| R-HSA-9031628 | NGF-stimulated transcription | 0.209920 | 0.678 |
| R-HSA-169893 | Prolonged ERK activation events | 0.262493 | 0.581 |
| R-HSA-1632852 | Macroautophagy | 0.221474 | 0.655 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.232171 | 0.634 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.271383 | 0.566 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.123342 | 0.909 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.170611 | 0.768 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.170611 | 0.768 |
| R-HSA-9701898 | STAT3 nuclear events downstream of ALK signaling | 0.251173 | 0.600 |
| R-HSA-9856532 | Mechanical load activates signaling by PIEZO1 and integrins in osteocytes | 0.306096 | 0.514 |
| R-HSA-2173789 | TGF-beta receptor signaling activates SMADs | 0.182460 | 0.739 |
| R-HSA-8986944 | Transcriptional Regulation by MECP2 | 0.196180 | 0.707 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.288195 | 0.540 |
| R-HSA-9663891 | Selective autophagy | 0.184711 | 0.734 |
| R-HSA-877300 | Interferon gamma signaling | 0.283983 | 0.547 |
| R-HSA-9758941 | Gastrulation | 0.250667 | 0.601 |
| R-HSA-9768919 | NPAS4 regulates expression of target genes | 0.129637 | 0.887 |
| R-HSA-9612973 | Autophagy | 0.273909 | 0.562 |
| R-HSA-8940973 | RUNX2 regulates osteoblast differentiation | 0.095336 | 1.021 |
| R-HSA-909733 | Interferon alpha/beta signaling | 0.135465 | 0.868 |
| R-HSA-1483255 | PI Metabolism | 0.247602 | 0.606 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.069029 | 1.161 |
| R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 0.177168 | 0.752 |
| R-HSA-2262752 | Cellular responses to stress | 0.074405 | 1.128 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.104846 | 0.979 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.095232 | 1.021 |
| R-HSA-166520 | Signaling by NTRKs | 0.111232 | 0.954 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.082155 | 1.085 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.262493 | 0.581 |
| R-HSA-9945266 | Differentiation of T cells | 0.262493 | 0.581 |
| R-HSA-450294 | MAP kinase activation | 0.282595 | 0.549 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.147943 | 0.830 |
| R-HSA-9006936 | Signaling by TGFB family members | 0.287353 | 0.542 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.075353 | 1.123 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.331586 | 0.479 |
| R-HSA-448424 | Interleukin-17 signaling | 0.332737 | 0.478 |
| R-HSA-68875 | Mitotic Prophase | 0.333853 | 0.476 |
| R-HSA-3371556 | Cellular response to heat stress | 0.337987 | 0.471 |
| R-HSA-975634 | Retinoid metabolism and transport | 0.338256 | 0.471 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.341863 | 0.466 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.343762 | 0.464 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | 0.347131 | 0.460 |
| R-HSA-350054 | Notch-HLH transcription pathway | 0.347131 | 0.460 |
| R-HSA-212676 | Dopamine Neurotransmitter Release Cycle | 0.347131 | 0.460 |
| R-HSA-8964038 | LDL clearance | 0.347131 | 0.460 |
| R-HSA-69052 | Switching of origins to a post-replicative state | 0.349253 | 0.457 |
| R-HSA-4086398 | Ca2+ pathway | 0.349253 | 0.457 |
| R-HSA-3000170 | Syndecan interactions | 0.357006 | 0.447 |
| R-HSA-5689603 | UCH proteinases | 0.365630 | 0.437 |
| R-HSA-8863678 | Neurodegenerative Diseases | 0.366733 | 0.436 |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis... | 0.366733 | 0.436 |
| R-HSA-181430 | Norepinephrine Neurotransmitter Release Cycle | 0.366733 | 0.436 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.366733 | 0.436 |
| R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane | 0.376312 | 0.424 |
| R-HSA-3000157 | Laminin interactions | 0.376312 | 0.424 |
| R-HSA-9703465 | Signaling by FLT3 fusion proteins | 0.385748 | 0.414 |
| R-HSA-210500 | Glutamate Neurotransmitter Release Cycle | 0.385748 | 0.414 |
| R-HSA-400042 | Adrenaline,noradrenaline inhibits insulin secretion | 0.385748 | 0.414 |
| R-HSA-9865118 | Diseases of branched-chain amino acid catabolism | 0.385748 | 0.414 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.385748 | 0.414 |
| R-HSA-9833482 | PKR-mediated signaling | 0.387214 | 0.412 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.387214 | 0.412 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.392561 | 0.406 |
| R-HSA-73863 | RNA Polymerase I Transcription Termination | 0.395042 | 0.403 |
| R-HSA-9734009 | Defective Intrinsic Pathway for Apoptosis | 0.395042 | 0.403 |
| R-HSA-5357956 | TNFR1-induced NF-kappa-B signaling pathway | 0.395042 | 0.403 |
| R-HSA-9006115 | Signaling by NTRK2 (TRKB) | 0.395042 | 0.403 |
| R-HSA-5576892 | Phase 0 - rapid depolarisation | 0.404195 | 0.393 |
| R-HSA-9619483 | Activation of AMPK downstream of NMDARs | 0.404195 | 0.393 |
| R-HSA-5620971 | Pyroptosis | 0.404195 | 0.393 |
| R-HSA-9757110 | Prednisone ADME | 0.404195 | 0.393 |
| R-HSA-9006335 | Signaling by Erythropoietin | 0.413210 | 0.384 |
| R-HSA-392154 | Nitric oxide stimulates guanylate cyclase | 0.413210 | 0.384 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.413732 | 0.383 |
| R-HSA-68962 | Activation of the pre-replicative complex | 0.422090 | 0.375 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.422090 | 0.375 |
| R-HSA-76046 | RNA Polymerase III Transcription Initiation | 0.422090 | 0.375 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.422090 | 0.375 |
| R-HSA-6807070 | PTEN Regulation | 0.423821 | 0.373 |
| R-HSA-8957322 | Metabolism of steroids | 0.425428 | 0.371 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.427217 | 0.369 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.427217 | 0.369 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.430836 | 0.366 |
| R-HSA-186763 | Downstream signal transduction | 0.430836 | 0.366 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.439450 | 0.357 |
| R-HSA-69190 | DNA strand elongation | 0.439450 | 0.357 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.439797 | 0.357 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.447934 | 0.349 |
| R-HSA-176187 | Activation of ATR in response to replication stress | 0.447934 | 0.349 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.447934 | 0.349 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.456290 | 0.341 |
| R-HSA-69242 | S Phase | 0.463435 | 0.334 |
| R-HSA-6814122 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | 0.464520 | 0.333 |
| R-HSA-190861 | Gap junction assembly | 0.464520 | 0.333 |
| R-HSA-9843970 | Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex | 0.464520 | 0.333 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.464520 | 0.333 |
| R-HSA-5365859 | RA biosynthesis pathway | 0.464520 | 0.333 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 0.464520 | 0.333 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.469950 | 0.328 |
| R-HSA-187687 | Signalling to ERKs | 0.472626 | 0.325 |
| R-HSA-9860927 | Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ... | 0.472626 | 0.325 |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | 0.475093 | 0.323 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.480610 | 0.318 |
| R-HSA-9682385 | FLT3 signaling in disease | 0.480610 | 0.318 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.480610 | 0.318 |
| R-HSA-3371511 | HSF1 activation | 0.480610 | 0.318 |
| R-HSA-111933 | Calmodulin induced events | 0.480610 | 0.318 |
| R-HSA-111997 | CaM pathway | 0.480610 | 0.318 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.484722 | 0.315 |
| R-HSA-162582 | Signal Transduction | 0.486043 | 0.313 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.486521 | 0.313 |
| R-HSA-73887 | Death Receptor Signaling | 0.486634 | 0.313 |
| R-HSA-1296072 | Voltage gated Potassium channels | 0.488474 | 0.311 |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | 0.488474 | 0.311 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.488474 | 0.311 |
| R-HSA-419037 | NCAM1 interactions | 0.488474 | 0.311 |
| R-HSA-170834 | Signaling by TGF-beta Receptor Complex | 0.489589 | 0.310 |
| R-HSA-422356 | Regulation of insulin secretion | 0.494427 | 0.306 |
| R-HSA-975871 | MyD88 cascade initiated on plasma membrane | 0.494427 | 0.306 |
| R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade | 0.494427 | 0.306 |
| R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade | 0.494427 | 0.306 |
| R-HSA-8875878 | MET promotes cell motility | 0.496219 | 0.304 |
| R-HSA-193704 | p75 NTR receptor-mediated signalling | 0.499236 | 0.302 |
| R-HSA-9725554 | Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin | 0.503847 | 0.298 |
| R-HSA-8964043 | Plasma lipoprotein clearance | 0.503847 | 0.298 |
| R-HSA-201556 | Signaling by ALK | 0.503847 | 0.298 |
| R-HSA-70171 | Glycolysis | 0.504016 | 0.298 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.509342 | 0.293 |
| R-HSA-3371568 | Attenuation phase | 0.511360 | 0.291 |
| R-HSA-9844594 | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 | 0.511360 | 0.291 |
| R-HSA-9843743 | Transcriptional regulation of brown and beige adipocyte differentiation | 0.511360 | 0.291 |
| R-HSA-9854311 | Maturation of TCA enzymes and regulation of TCA cycle | 0.511360 | 0.291 |
| R-HSA-202433 | Generation of second messenger molecules | 0.511360 | 0.291 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.513488 | 0.289 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.515923 | 0.287 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.518760 | 0.285 |
| R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene... | 0.518760 | 0.285 |
| R-HSA-9607240 | FLT3 Signaling | 0.518760 | 0.285 |
| R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 0.518760 | 0.285 |
| R-HSA-5610783 | Degradation of GLI2 by the proteasome | 0.526048 | 0.279 |
| R-HSA-5610780 | Degradation of GLI1 by the proteasome | 0.526048 | 0.279 |
| R-HSA-9609736 | Assembly and cell surface presentation of NMDA receptors | 0.526048 | 0.279 |
| R-HSA-9615017 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | 0.526048 | 0.279 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.527470 | 0.278 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.527470 | 0.278 |
| R-HSA-9833110 | RSV-host interactions | 0.527470 | 0.278 |
| R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade | 0.532071 | 0.274 |
| R-HSA-73762 | RNA Polymerase I Transcription Initiation | 0.533227 | 0.273 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.533227 | 0.273 |
| R-HSA-73928 | Depyrimidination | 0.533227 | 0.273 |
| R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | 0.533227 | 0.273 |
| R-HSA-111996 | Ca-dependent events | 0.533227 | 0.273 |
| R-HSA-379716 | Cytosolic tRNA aminoacylation | 0.533227 | 0.273 |
| R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 0.533227 | 0.273 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.536641 | 0.270 |
| R-HSA-69239 | Synthesis of DNA | 0.541180 | 0.267 |
| R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 0.545688 | 0.263 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.547260 | 0.262 |
| R-HSA-190828 | Gap junction trafficking | 0.547260 | 0.262 |
| R-HSA-69236 | G1 Phase | 0.547260 | 0.262 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.547260 | 0.262 |
| R-HSA-975155 | MyD88 dependent cascade initiated on endosome | 0.550166 | 0.260 |
| R-HSA-1489509 | DAG and IP3 signaling | 0.554118 | 0.256 |
| R-HSA-937061 | TRIF (TICAM1)-mediated TLR4 signaling | 0.554612 | 0.256 |
| R-HSA-166166 | MyD88-independent TLR4 cascade | 0.554612 | 0.256 |
| R-HSA-157118 | Signaling by NOTCH | 0.559382 | 0.252 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.560873 | 0.251 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.560873 | 0.251 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.560873 | 0.251 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.563412 | 0.249 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.567526 | 0.246 |
| R-HSA-437239 | Recycling pathway of L1 | 0.567526 | 0.246 |
| R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade | 0.567766 | 0.246 |
| R-HSA-9855142 | Cellular responses to mechanical stimuli | 0.572088 | 0.243 |
| R-HSA-73893 | DNA Damage Bypass | 0.580532 | 0.236 |
| R-HSA-157858 | Gap junction trafficking and regulation | 0.580532 | 0.236 |
| R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription | 0.580532 | 0.236 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.580637 | 0.236 |
| R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 0.580637 | 0.236 |
| R-HSA-168255 | Influenza Infection | 0.580998 | 0.236 |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | 0.586888 | 0.231 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.593149 | 0.227 |
| R-HSA-70895 | Branched-chain amino acid catabolism | 0.593149 | 0.227 |
| R-HSA-70326 | Glucose metabolism | 0.593227 | 0.227 |
| R-HSA-73772 | RNA Polymerase I Promoter Escape | 0.599314 | 0.222 |
| R-HSA-112382 | Formation of RNA Pol II elongation complex | 0.599314 | 0.222 |
| R-HSA-166058 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane | 0.601462 | 0.221 |
| R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade | 0.601462 | 0.221 |
| R-HSA-5250924 | B-WICH complex positively regulates rRNA expression | 0.605387 | 0.218 |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | 0.605387 | 0.218 |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ... | 0.605387 | 0.218 |
| R-HSA-445355 | Smooth Muscle Contraction | 0.605387 | 0.218 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.606373 | 0.217 |
| R-HSA-73886 | Chromosome Maintenance | 0.609572 | 0.215 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.611368 | 0.214 |
| R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade | 0.613580 | 0.212 |
| R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade | 0.613580 | 0.212 |
| R-HSA-3214815 | HDACs deacetylate histones | 0.617259 | 0.210 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.621501 | 0.207 |
| R-HSA-193648 | NRAGE signals death through JNK | 0.623061 | 0.205 |
| R-HSA-75893 | TNF signaling | 0.623061 | 0.205 |
| R-HSA-177929 | Signaling by EGFR | 0.623061 | 0.205 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.623061 | 0.205 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.623061 | 0.205 |
| R-HSA-69206 | G1/S Transition | 0.629298 | 0.201 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.629938 | 0.201 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.630224 | 0.201 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.639946 | 0.194 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.639946 | 0.194 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.645406 | 0.190 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.645406 | 0.190 |
| R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer | 0.645406 | 0.190 |
| R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | 0.645406 | 0.190 |
| R-HSA-5362517 | Signaling by Retinoic Acid | 0.645406 | 0.190 |
| R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer | 0.645406 | 0.190 |
| R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | 0.645406 | 0.190 |
| R-HSA-2644603 | Signaling by NOTCH1 in Cancer | 0.645406 | 0.190 |
| R-HSA-379724 | tRNA Aminoacylation | 0.645406 | 0.190 |
| R-HSA-2428928 | IRS-related events triggered by IGF1R | 0.650782 | 0.187 |
| R-HSA-112043 | PLC beta mediated events | 0.650782 | 0.187 |
| R-HSA-8953854 | Metabolism of RNA | 0.654847 | 0.184 |
| R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 0.656078 | 0.183 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.656078 | 0.183 |
| R-HSA-186797 | Signaling by PDGF | 0.656078 | 0.183 |
| R-HSA-6790901 | rRNA modification in the nucleus and cytosol | 0.661294 | 0.180 |
| R-HSA-373755 | Semaphorin interactions | 0.661294 | 0.180 |
| R-HSA-8848021 | Signaling by PTK6 | 0.661294 | 0.180 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.661294 | 0.180 |
| R-HSA-72172 | mRNA Splicing | 0.663708 | 0.178 |
| R-HSA-2428924 | IGF1R signaling cascade | 0.666431 | 0.176 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.668200 | 0.175 |
| R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | 0.671490 | 0.173 |
| R-HSA-163685 | Integration of energy metabolism | 0.676950 | 0.169 |
| R-HSA-3858494 | Beta-catenin independent WNT signaling | 0.676950 | 0.169 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.680402 | 0.167 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.681380 | 0.167 |
| R-HSA-112040 | G-protein mediated events | 0.681380 | 0.167 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.686214 | 0.164 |
| R-HSA-5218859 | Regulated Necrosis | 0.686214 | 0.164 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.689436 | 0.162 |
| R-HSA-199991 | Membrane Trafficking | 0.691948 | 0.160 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.695663 | 0.158 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.695663 | 0.158 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.699143 | 0.155 |
| R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 0.700280 | 0.155 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.700280 | 0.155 |
| R-HSA-9856649 | Transcriptional and post-translational regulation of MITF-M expression and activ... | 0.700280 | 0.155 |
| R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins | 0.700280 | 0.155 |
| R-HSA-453276 | Regulation of mitotic cell cycle | 0.700280 | 0.155 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.700486 | 0.155 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.704828 | 0.152 |
| R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 0.704828 | 0.152 |
| R-HSA-74259 | Purine catabolism | 0.704828 | 0.152 |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | 0.709307 | 0.149 |
| R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 0.709307 | 0.149 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.713287 | 0.147 |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | 0.713719 | 0.146 |
| R-HSA-2187338 | Visual phototransduction | 0.716415 | 0.145 |
| R-HSA-71403 | Citric acid cycle (TCA cycle) | 0.718064 | 0.144 |
| R-HSA-3000171 | Non-integrin membrane-ECM interactions | 0.718064 | 0.144 |
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | 0.719515 | 0.143 |
| R-HSA-73854 | RNA Polymerase I Promoter Clearance | 0.722343 | 0.141 |
| R-HSA-1980143 | Signaling by NOTCH1 | 0.722343 | 0.141 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.725629 | 0.139 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.728998 | 0.137 |
| R-HSA-73864 | RNA Polymerase I Transcription | 0.730708 | 0.136 |
| R-HSA-416482 | G alpha (12/13) signalling events | 0.730708 | 0.136 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.731630 | 0.136 |
| R-HSA-69306 | DNA Replication | 0.734589 | 0.134 |
| R-HSA-9659379 | Sensory processing of sound | 0.734796 | 0.134 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.738822 | 0.131 |
| R-HSA-6806834 | Signaling by MET | 0.738822 | 0.131 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.740424 | 0.131 |
| R-HSA-9610379 | HCMV Late Events | 0.746149 | 0.127 |
| R-HSA-162587 | HIV Life Cycle | 0.746149 | 0.127 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.754327 | 0.122 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.754327 | 0.122 |
| R-HSA-112316 | Neuronal System | 0.756120 | 0.121 |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | 0.761732 | 0.118 |
| R-HSA-438064 | Post NMDA receptor activation events | 0.768915 | 0.114 |
| R-HSA-9645723 | Diseases of programmed cell death | 0.772425 | 0.112 |
| R-HSA-211897 | Cytochrome P450 - arranged by substrate type | 0.773177 | 0.112 |
| R-HSA-5619102 | SLC transporter disorders | 0.773177 | 0.112 |
| R-HSA-112310 | Neurotransmitter release cycle | 0.779287 | 0.108 |
| R-HSA-73884 | Base Excision Repair | 0.779287 | 0.108 |
| R-HSA-72306 | tRNA processing | 0.783269 | 0.106 |
| R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance | 0.789195 | 0.103 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.790578 | 0.102 |
| R-HSA-68867 | Assembly of the pre-replicative complex | 0.792398 | 0.101 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.795330 | 0.099 |
| R-HSA-1474290 | Collagen formation | 0.795553 | 0.099 |
| R-HSA-597592 | Post-translational protein modification | 0.799893 | 0.097 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.802380 | 0.096 |
| R-HSA-5389840 | Mitochondrial translation elongation | 0.804734 | 0.094 |
| R-HSA-1296071 | Potassium Channels | 0.804734 | 0.094 |
| R-HSA-2559583 | Cellular Senescence | 0.806795 | 0.093 |
| R-HSA-5368286 | Mitochondrial translation initiation | 0.810625 | 0.091 |
| R-HSA-190236 | Signaling by FGFR | 0.810625 | 0.091 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.813504 | 0.090 |
| R-HSA-9842860 | Regulation of endogenous retroelements | 0.821881 | 0.085 |
| R-HSA-442755 | Activation of NMDA receptors and postsynaptic events | 0.821881 | 0.085 |
| R-HSA-9937383 | Mitochondrial ribosome-associated quality control | 0.824590 | 0.084 |
| R-HSA-111885 | Opioid Signalling | 0.827257 | 0.082 |
| R-HSA-9860931 | Response of endothelial cells to shear stress | 0.827257 | 0.082 |
| R-HSA-168898 | Toll-like Receptor Cascades | 0.830033 | 0.081 |
| R-HSA-1280218 | Adaptive Immune System | 0.830889 | 0.080 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.832471 | 0.080 |
| R-HSA-418346 | Platelet homeostasis | 0.835019 | 0.078 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.837529 | 0.077 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.837529 | 0.077 |
| R-HSA-9824443 | Parasitic Infection Pathways | 0.837786 | 0.077 |
| R-HSA-9658195 | Leishmania infection | 0.837786 | 0.077 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.839417 | 0.076 |
| R-HSA-9734779 | Developmental Cell Lineages of the Integumentary System | 0.840000 | 0.076 |
| R-HSA-5419276 | Mitochondrial translation termination | 0.842434 | 0.074 |
| R-HSA-69002 | DNA Replication Pre-Initiation | 0.842434 | 0.074 |
| R-HSA-202403 | TCR signaling | 0.844831 | 0.073 |
| R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | 0.849517 | 0.071 |
| R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 0.849517 | 0.071 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.850446 | 0.070 |
| R-HSA-5357801 | Programmed Cell Death | 0.857673 | 0.067 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.859371 | 0.066 |
| R-HSA-1483257 | Phospholipid metabolism | 0.859371 | 0.066 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.860812 | 0.065 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.863994 | 0.063 |
| R-HSA-9007101 | Rab regulation of trafficking | 0.864835 | 0.063 |
| R-HSA-397014 | Muscle contraction | 0.869117 | 0.061 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.876722 | 0.057 |
| R-HSA-8951664 | Neddylation | 0.882592 | 0.054 |
| R-HSA-114608 | Platelet degranulation | 0.885828 | 0.053 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.887545 | 0.052 |
| R-HSA-8956319 | Nucleotide catabolism | 0.889280 | 0.051 |
| R-HSA-162906 | HIV Infection | 0.890853 | 0.050 |
| R-HSA-5576891 | Cardiac conduction | 0.894264 | 0.049 |
| R-HSA-112315 | Transmission across Chemical Synapses | 0.895129 | 0.048 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.897462 | 0.047 |
| R-HSA-5368287 | Mitochondrial translation | 0.906489 | 0.043 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.907915 | 0.042 |
| R-HSA-9664422 | FCGR3A-mediated phagocytosis | 0.909319 | 0.041 |
| R-HSA-9664407 | Parasite infection | 0.909319 | 0.041 |
| R-HSA-9664417 | Leishmania phagocytosis | 0.909319 | 0.041 |
| R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation | 0.910702 | 0.041 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.912585 | 0.040 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.914658 | 0.039 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.920814 | 0.036 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.923424 | 0.035 |
| R-HSA-2142753 | Arachidonate metabolism | 0.925743 | 0.034 |
| R-HSA-422475 | Axon guidance | 0.933812 | 0.030 |
| R-HSA-6798695 | Neutrophil degranulation | 0.934209 | 0.030 |
| R-HSA-109581 | Apoptosis | 0.936330 | 0.029 |
| R-HSA-9679506 | SARS-CoV Infections | 0.939794 | 0.027 |
| R-HSA-211945 | Phase I - Functionalization of compounds | 0.942166 | 0.026 |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | 0.944566 | 0.025 |
| R-HSA-418555 | G alpha (s) signalling events | 0.945413 | 0.024 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.946367 | 0.024 |
| R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | 0.947877 | 0.023 |
| R-HSA-9675108 | Nervous system development | 0.953601 | 0.021 |
| R-HSA-556833 | Metabolism of lipids | 0.955048 | 0.020 |
| R-HSA-1266738 | Developmental Biology | 0.955120 | 0.020 |
| R-HSA-195721 | Signaling by WNT | 0.955205 | 0.020 |
| R-HSA-8868773 | rRNA processing in the nucleus and cytosol | 0.957989 | 0.019 |
| R-HSA-392499 | Metabolism of proteins | 0.958671 | 0.018 |
| R-HSA-9824446 | Viral Infection Pathways | 0.965615 | 0.015 |
| R-HSA-449147 | Signaling by Interleukins | 0.969765 | 0.013 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 0.971432 | 0.013 |
| R-HSA-9748784 | Drug ADME | 0.973959 | 0.011 |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.978029 | 0.010 |
| R-HSA-72312 | rRNA processing | 0.979024 | 0.009 |
| R-HSA-15869 | Metabolism of nucleotides | 0.980282 | 0.009 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.981115 | 0.008 |
| R-HSA-168256 | Immune System | 0.981723 | 0.008 |
| R-HSA-109582 | Hemostasis | 0.984553 | 0.007 |
| R-HSA-9734767 | Developmental Cell Lineages | 0.987016 | 0.006 |
| R-HSA-425407 | SLC-mediated transmembrane transport | 0.988025 | 0.005 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.989050 | 0.005 |
| R-HSA-72766 | Translation | 0.992243 | 0.003 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.994569 | 0.002 |
| R-HSA-1474244 | Extracellular matrix organization | 0.995481 | 0.002 |
| R-HSA-1428517 | Aerobic respiration and respiratory electron transport | 0.996132 | 0.002 |
| R-HSA-211859 | Biological oxidations | 0.997891 | 0.001 |
| R-HSA-418594 | G alpha (i) signalling events | 0.998640 | 0.001 |
| R-HSA-8978868 | Fatty acid metabolism | 0.998640 | 0.001 |
| R-HSA-5663205 | Infectious disease | 0.998896 | 0.000 |
| R-HSA-168249 | Innate Immune System | 0.998962 | 0.000 |
| R-HSA-5668914 | Diseases of metabolism | 0.999005 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999461 | 0.000 |
| R-HSA-388396 | GPCR downstream signalling | 0.999944 | 0.000 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999951 | 0.000 |
| R-HSA-1643685 | Disease | 0.999964 | 0.000 |
| R-HSA-372790 | Signaling by GPCR | 0.999984 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999999 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK18 |
0.890 | 0.867 | 1 | 0.869 |
CDK17 |
0.890 | 0.884 | 1 | 0.894 |
CDK3 |
0.888 | 0.806 | 1 | 0.889 |
P38G |
0.887 | 0.897 | 1 | 0.903 |
CDK19 |
0.883 | 0.838 | 1 | 0.857 |
JNK2 |
0.883 | 0.898 | 1 | 0.870 |
CDK7 |
0.882 | 0.841 | 1 | 0.828 |
CDK16 |
0.881 | 0.850 | 1 | 0.882 |
CDK5 |
0.881 | 0.837 | 1 | 0.799 |
HIPK2 |
0.881 | 0.792 | 1 | 0.848 |
CDK8 |
0.880 | 0.841 | 1 | 0.825 |
CDK1 |
0.879 | 0.851 | 1 | 0.846 |
ERK1 |
0.878 | 0.855 | 1 | 0.859 |
KIS |
0.878 | 0.760 | 1 | 0.804 |
P38D |
0.877 | 0.874 | 1 | 0.908 |
CDK13 |
0.877 | 0.846 | 1 | 0.848 |
P38B |
0.877 | 0.861 | 1 | 0.842 |
CDK12 |
0.875 | 0.848 | 1 | 0.868 |
CDK14 |
0.874 | 0.847 | 1 | 0.831 |
DYRK2 |
0.873 | 0.782 | 1 | 0.767 |
JNK3 |
0.873 | 0.882 | 1 | 0.845 |
CDK10 |
0.869 | 0.795 | 1 | 0.846 |
CDK9 |
0.869 | 0.830 | 1 | 0.842 |
P38A |
0.867 | 0.833 | 1 | 0.777 |
DYRK4 |
0.867 | 0.790 | 1 | 0.860 |
CDK4 |
0.866 | 0.841 | 1 | 0.873 |
ERK2 |
0.865 | 0.851 | 1 | 0.807 |
DYRK1B |
0.865 | 0.765 | 1 | 0.815 |
CDK6 |
0.864 | 0.819 | 1 | 0.851 |
HIPK1 |
0.863 | 0.724 | 1 | 0.750 |
NLK |
0.863 | 0.784 | 1 | 0.570 |
CDK2 |
0.860 | 0.697 | 1 | 0.728 |
CLK3 |
0.859 | 0.511 | 1 | 0.526 |
DYRK1A |
0.859 | 0.658 | 1 | 0.734 |
HIPK4 |
0.858 | 0.502 | 1 | 0.556 |
HIPK3 |
0.858 | 0.714 | 1 | 0.725 |
SRPK1 |
0.851 | 0.375 | -3 | 0.797 |
JNK1 |
0.850 | 0.790 | 1 | 0.868 |
ERK5 |
0.850 | 0.434 | 1 | 0.492 |
DYRK3 |
0.848 | 0.592 | 1 | 0.713 |
CLK1 |
0.844 | 0.458 | -3 | 0.788 |
ICK |
0.841 | 0.411 | -3 | 0.867 |
SRPK2 |
0.841 | 0.311 | -3 | 0.721 |
CLK4 |
0.839 | 0.422 | -3 | 0.801 |
MAK |
0.839 | 0.542 | -2 | 0.825 |
CDKL5 |
0.838 | 0.214 | -3 | 0.834 |
MTOR |
0.836 | 0.219 | 1 | 0.370 |
CDKL1 |
0.834 | 0.188 | -3 | 0.837 |
CLK2 |
0.833 | 0.433 | -3 | 0.784 |
PRP4 |
0.832 | 0.484 | -3 | 0.778 |
COT |
0.830 | -0.074 | 2 | 0.853 |
MOK |
0.829 | 0.500 | 1 | 0.640 |
SRPK3 |
0.826 | 0.265 | -3 | 0.764 |
MOS |
0.823 | -0.023 | 1 | 0.237 |
TBK1 |
0.822 | -0.147 | 1 | 0.169 |
CDC7 |
0.822 | -0.112 | 1 | 0.193 |
PRPK |
0.822 | -0.098 | -1 | 0.881 |
CAMK1B |
0.820 | -0.002 | -3 | 0.885 |
MST4 |
0.819 | -0.006 | 2 | 0.827 |
PKN3 |
0.819 | -0.017 | -3 | 0.846 |
NUAK2 |
0.818 | 0.040 | -3 | 0.855 |
ATR |
0.818 | -0.051 | 1 | 0.236 |
ULK2 |
0.818 | -0.160 | 2 | 0.794 |
IKKE |
0.818 | -0.160 | 1 | 0.167 |
PRKD1 |
0.817 | 0.007 | -3 | 0.856 |
WNK1 |
0.817 | -0.057 | -2 | 0.908 |
PIM3 |
0.817 | -0.028 | -3 | 0.846 |
RAF1 |
0.817 | -0.180 | 1 | 0.184 |
ERK7 |
0.817 | 0.264 | 2 | 0.500 |
GCN2 |
0.816 | -0.187 | 2 | 0.780 |
NIK |
0.816 | -0.024 | -3 | 0.888 |
CAMLCK |
0.816 | 0.024 | -2 | 0.909 |
BMPR2 |
0.816 | -0.159 | -2 | 0.915 |
PKCD |
0.816 | 0.010 | 2 | 0.789 |
PDHK4 |
0.814 | -0.180 | 1 | 0.250 |
PKN2 |
0.814 | -0.028 | -3 | 0.854 |
RIPK3 |
0.814 | -0.107 | 3 | 0.818 |
NDR2 |
0.813 | -0.036 | -3 | 0.840 |
NDR1 |
0.813 | -0.038 | -3 | 0.844 |
AMPKA1 |
0.813 | -0.028 | -3 | 0.863 |
NEK6 |
0.813 | -0.079 | -2 | 0.870 |
SKMLCK |
0.813 | -0.030 | -2 | 0.898 |
PRKD2 |
0.812 | 0.019 | -3 | 0.805 |
CHAK2 |
0.812 | -0.058 | -1 | 0.853 |
TGFBR2 |
0.812 | -0.083 | -2 | 0.810 |
MARK4 |
0.812 | -0.041 | 4 | 0.879 |
DSTYK |
0.811 | -0.148 | 2 | 0.864 |
DAPK2 |
0.811 | -0.012 | -3 | 0.885 |
NIM1 |
0.811 | -0.048 | 3 | 0.841 |
IRE1 |
0.811 | -0.068 | 1 | 0.177 |
WNK3 |
0.811 | -0.154 | 1 | 0.185 |
P90RSK |
0.810 | 0.011 | -3 | 0.813 |
PDHK1 |
0.810 | -0.189 | 1 | 0.230 |
IKKB |
0.810 | -0.181 | -2 | 0.797 |
RSK3 |
0.809 | 0.002 | -3 | 0.802 |
MLK1 |
0.809 | -0.125 | 2 | 0.812 |
RSK2 |
0.809 | 0.008 | -3 | 0.810 |
AMPKA2 |
0.809 | -0.013 | -3 | 0.835 |
NEK7 |
0.809 | -0.163 | -3 | 0.832 |
IRE2 |
0.809 | -0.046 | 2 | 0.784 |
MLK2 |
0.809 | -0.097 | 2 | 0.809 |
PIM1 |
0.809 | 0.029 | -3 | 0.803 |
PRKD3 |
0.808 | 0.027 | -3 | 0.790 |
TSSK1 |
0.808 | -0.023 | -3 | 0.881 |
MELK |
0.807 | -0.030 | -3 | 0.830 |
PHKG1 |
0.807 | -0.038 | -3 | 0.839 |
HUNK |
0.806 | -0.145 | 2 | 0.822 |
MAPKAPK3 |
0.806 | -0.041 | -3 | 0.803 |
ULK1 |
0.806 | -0.164 | -3 | 0.817 |
PKCB |
0.805 | -0.001 | 2 | 0.750 |
NUAK1 |
0.805 | -0.006 | -3 | 0.810 |
MASTL |
0.805 | -0.160 | -2 | 0.871 |
TSSK2 |
0.805 | -0.058 | -5 | 0.856 |
CAMK2G |
0.805 | -0.130 | 2 | 0.779 |
MLK3 |
0.805 | -0.041 | 2 | 0.747 |
P70S6KB |
0.804 | -0.006 | -3 | 0.824 |
NEK9 |
0.804 | -0.163 | 2 | 0.831 |
PAK6 |
0.804 | 0.029 | -2 | 0.789 |
PKCA |
0.804 | -0.002 | 2 | 0.737 |
AURC |
0.804 | 0.029 | -2 | 0.718 |
MNK2 |
0.804 | -0.012 | -2 | 0.852 |
PKCG |
0.803 | -0.013 | 2 | 0.746 |
PAK3 |
0.803 | -0.043 | -2 | 0.854 |
PKACG |
0.803 | -0.022 | -2 | 0.802 |
PINK1 |
0.802 | 0.177 | 1 | 0.392 |
PKCZ |
0.802 | -0.031 | 2 | 0.779 |
VRK2 |
0.802 | 0.058 | 1 | 0.285 |
QIK |
0.802 | -0.064 | -3 | 0.847 |
RIPK1 |
0.801 | -0.181 | 1 | 0.172 |
BCKDK |
0.801 | -0.156 | -1 | 0.841 |
LATS2 |
0.801 | -0.061 | -5 | 0.769 |
QSK |
0.800 | -0.015 | 4 | 0.868 |
MPSK1 |
0.800 | 0.051 | 1 | 0.254 |
AKT2 |
0.800 | 0.057 | -3 | 0.732 |
ANKRD3 |
0.800 | -0.171 | 1 | 0.203 |
SIK |
0.800 | -0.015 | -3 | 0.784 |
GRK5 |
0.800 | -0.183 | -3 | 0.839 |
PAK1 |
0.800 | -0.032 | -2 | 0.851 |
PKR |
0.799 | -0.084 | 1 | 0.197 |
PKCH |
0.799 | -0.031 | 2 | 0.744 |
DNAPK |
0.799 | -0.054 | 1 | 0.229 |
MNK1 |
0.799 | -0.008 | -2 | 0.865 |
LATS1 |
0.798 | -0.010 | -3 | 0.848 |
CAMK4 |
0.798 | -0.095 | -3 | 0.832 |
CAMK2D |
0.798 | -0.112 | -3 | 0.862 |
ATM |
0.798 | -0.087 | 1 | 0.201 |
PKG2 |
0.798 | 0.014 | -2 | 0.735 |
DLK |
0.797 | -0.217 | 1 | 0.194 |
IKKA |
0.797 | -0.128 | -2 | 0.778 |
MSK2 |
0.797 | -0.020 | -3 | 0.776 |
MAPKAPK2 |
0.797 | -0.029 | -3 | 0.758 |
YSK4 |
0.797 | -0.153 | 1 | 0.171 |
SGK3 |
0.796 | 0.004 | -3 | 0.786 |
CHAK1 |
0.796 | -0.123 | 2 | 0.771 |
SMG1 |
0.796 | -0.067 | 1 | 0.222 |
BRSK2 |
0.796 | -0.066 | -3 | 0.835 |
GRK1 |
0.796 | -0.071 | -2 | 0.815 |
NEK2 |
0.795 | -0.135 | 2 | 0.808 |
AURB |
0.795 | 0.004 | -2 | 0.721 |
PIM2 |
0.795 | 0.030 | -3 | 0.784 |
PKCT |
0.795 | -0.018 | 2 | 0.748 |
BMPR1B |
0.795 | -0.070 | 1 | 0.160 |
MEK1 |
0.795 | -0.137 | 2 | 0.826 |
IRAK4 |
0.795 | -0.090 | 1 | 0.161 |
MYLK4 |
0.794 | -0.007 | -2 | 0.830 |
ALK4 |
0.794 | -0.089 | -2 | 0.844 |
TGFBR1 |
0.794 | -0.077 | -2 | 0.809 |
PHKG2 |
0.794 | -0.044 | -3 | 0.826 |
MARK3 |
0.793 | -0.024 | 4 | 0.832 |
MARK2 |
0.793 | -0.030 | 4 | 0.802 |
SNRK |
0.793 | -0.119 | 2 | 0.699 |
PLK4 |
0.792 | -0.122 | 2 | 0.654 |
GRK6 |
0.792 | -0.171 | 1 | 0.177 |
PAK2 |
0.792 | -0.059 | -2 | 0.842 |
DCAMKL1 |
0.792 | -0.033 | -3 | 0.805 |
MST3 |
0.791 | -0.035 | 2 | 0.830 |
BRSK1 |
0.791 | -0.052 | -3 | 0.814 |
CAMK1G |
0.791 | -0.033 | -3 | 0.799 |
RSK4 |
0.791 | 0.000 | -3 | 0.770 |
PKACB |
0.791 | 0.024 | -2 | 0.731 |
TTBK2 |
0.790 | -0.210 | 2 | 0.712 |
MLK4 |
0.790 | -0.116 | 2 | 0.719 |
PKCI |
0.790 | -0.005 | 2 | 0.749 |
WNK4 |
0.790 | -0.111 | -2 | 0.901 |
AKT1 |
0.790 | 0.033 | -3 | 0.743 |
SSTK |
0.790 | -0.027 | 4 | 0.861 |
MEK5 |
0.789 | -0.139 | 2 | 0.820 |
HRI |
0.789 | -0.143 | -2 | 0.877 |
PLK1 |
0.789 | -0.160 | -2 | 0.839 |
CHK1 |
0.788 | -0.070 | -3 | 0.817 |
MEKK1 |
0.788 | -0.147 | 1 | 0.195 |
PKN1 |
0.788 | 0.001 | -3 | 0.766 |
MSK1 |
0.788 | -0.013 | -3 | 0.777 |
ZAK |
0.787 | -0.152 | 1 | 0.179 |
GRK7 |
0.787 | -0.053 | 1 | 0.208 |
ACVR2B |
0.787 | -0.114 | -2 | 0.815 |
MARK1 |
0.786 | -0.060 | 4 | 0.849 |
PKCE |
0.786 | 0.030 | 2 | 0.740 |
TAO3 |
0.786 | -0.046 | 1 | 0.215 |
DRAK1 |
0.786 | -0.144 | 1 | 0.158 |
PERK |
0.786 | -0.156 | -2 | 0.866 |
ACVR2A |
0.786 | -0.117 | -2 | 0.804 |
NEK5 |
0.786 | -0.141 | 1 | 0.183 |
MEKK2 |
0.785 | -0.123 | 2 | 0.805 |
DCAMKL2 |
0.785 | -0.048 | -3 | 0.833 |
GSK3A |
0.785 | 0.159 | 4 | 0.368 |
PAK5 |
0.785 | -0.006 | -2 | 0.724 |
SMMLCK |
0.785 | -0.012 | -3 | 0.849 |
GRK4 |
0.785 | -0.207 | -2 | 0.842 |
TAO2 |
0.784 | -0.032 | 2 | 0.846 |
FAM20C |
0.784 | -0.026 | 2 | 0.612 |
AURA |
0.784 | -0.012 | -2 | 0.693 |
CAMK2A |
0.784 | -0.060 | 2 | 0.746 |
MAPKAPK5 |
0.783 | -0.079 | -3 | 0.756 |
PDK1 |
0.783 | -0.046 | 1 | 0.227 |
MEKK6 |
0.783 | -0.073 | 1 | 0.196 |
PAK4 |
0.782 | 0.005 | -2 | 0.730 |
BRAF |
0.782 | -0.150 | -4 | 0.824 |
CAMK2B |
0.782 | -0.101 | 2 | 0.727 |
MEKK3 |
0.781 | -0.180 | 1 | 0.189 |
TLK2 |
0.781 | -0.179 | 1 | 0.169 |
ALK2 |
0.781 | -0.118 | -2 | 0.818 |
MAP3K15 |
0.780 | -0.086 | 1 | 0.195 |
NEK11 |
0.780 | -0.132 | 1 | 0.212 |
PRKX |
0.780 | 0.032 | -3 | 0.697 |
SBK |
0.780 | 0.136 | -3 | 0.626 |
NEK8 |
0.780 | -0.139 | 2 | 0.824 |
PBK |
0.780 | -0.017 | 1 | 0.227 |
HGK |
0.779 | -0.051 | 3 | 0.937 |
P70S6K |
0.779 | -0.029 | -3 | 0.746 |
AKT3 |
0.779 | 0.043 | -3 | 0.673 |
GAK |
0.779 | -0.045 | 1 | 0.243 |
LKB1 |
0.778 | -0.068 | -3 | 0.830 |
NEK4 |
0.778 | -0.132 | 1 | 0.168 |
TNIK |
0.778 | -0.025 | 3 | 0.946 |
BUB1 |
0.778 | 0.022 | -5 | 0.800 |
PKACA |
0.778 | 0.016 | -2 | 0.682 |
MINK |
0.777 | -0.090 | 1 | 0.172 |
GCK |
0.777 | -0.079 | 1 | 0.193 |
KHS1 |
0.776 | -0.032 | 1 | 0.188 |
BMPR1A |
0.776 | -0.090 | 1 | 0.149 |
GRK2 |
0.776 | -0.116 | -2 | 0.724 |
IRAK1 |
0.776 | -0.187 | -1 | 0.795 |
PLK3 |
0.775 | -0.172 | 2 | 0.754 |
MRCKB |
0.775 | 0.021 | -3 | 0.771 |
LOK |
0.775 | -0.061 | -2 | 0.840 |
HPK1 |
0.775 | -0.064 | 1 | 0.193 |
CAMK1D |
0.775 | -0.025 | -3 | 0.719 |
CHK2 |
0.774 | 0.005 | -3 | 0.685 |
LRRK2 |
0.774 | -0.025 | 2 | 0.839 |
GSK3B |
0.773 | 0.012 | 4 | 0.360 |
NEK1 |
0.773 | -0.124 | 1 | 0.164 |
SGK1 |
0.773 | 0.047 | -3 | 0.653 |
MST2 |
0.773 | -0.127 | 1 | 0.179 |
TLK1 |
0.772 | -0.185 | -2 | 0.825 |
ROCK2 |
0.772 | 0.007 | -3 | 0.805 |
DAPK3 |
0.772 | -0.023 | -3 | 0.822 |
CK1E |
0.772 | -0.051 | -3 | 0.523 |
KHS2 |
0.772 | -0.017 | 1 | 0.199 |
CAMK1A |
0.772 | 0.003 | -3 | 0.701 |
CAMKK1 |
0.772 | -0.187 | -2 | 0.819 |
PASK |
0.771 | -0.082 | -3 | 0.855 |
MRCKA |
0.771 | 0.002 | -3 | 0.779 |
EEF2K |
0.770 | -0.070 | 3 | 0.903 |
HASPIN |
0.770 | 0.018 | -1 | 0.711 |
CAMKK2 |
0.770 | -0.155 | -2 | 0.826 |
TTBK1 |
0.769 | -0.177 | 2 | 0.639 |
VRK1 |
0.769 | -0.140 | 2 | 0.859 |
YSK1 |
0.769 | -0.098 | 2 | 0.805 |
RIPK2 |
0.769 | -0.174 | 1 | 0.165 |
TAK1 |
0.769 | -0.155 | 1 | 0.175 |
NEK3 |
0.767 | -0.102 | 1 | 0.197 |
MST1 |
0.766 | -0.130 | 1 | 0.169 |
BIKE |
0.766 | -0.016 | 1 | 0.235 |
DMPK1 |
0.765 | 0.043 | -3 | 0.792 |
SLK |
0.764 | -0.084 | -2 | 0.775 |
DAPK1 |
0.764 | -0.031 | -3 | 0.809 |
PKG1 |
0.764 | -0.005 | -2 | 0.655 |
CK1D |
0.764 | -0.032 | -3 | 0.474 |
MEK2 |
0.763 | -0.182 | 2 | 0.807 |
AAK1 |
0.762 | 0.019 | 1 | 0.241 |
ROCK1 |
0.762 | 0.003 | -3 | 0.780 |
TAO1 |
0.759 | -0.064 | 1 | 0.185 |
STK33 |
0.759 | -0.141 | 2 | 0.608 |
CK1G1 |
0.759 | -0.096 | -3 | 0.515 |
MYO3B |
0.759 | -0.053 | 2 | 0.821 |
CK1A2 |
0.758 | -0.055 | -3 | 0.475 |
MYO3A |
0.757 | -0.052 | 1 | 0.182 |
CRIK |
0.757 | 0.011 | -3 | 0.742 |
ASK1 |
0.756 | -0.114 | 1 | 0.194 |
GRK3 |
0.755 | -0.128 | -2 | 0.668 |
CK2A2 |
0.754 | -0.112 | 1 | 0.144 |
TTK |
0.753 | -0.087 | -2 | 0.837 |
OSR1 |
0.752 | -0.100 | 2 | 0.773 |
LIMK2_TYR |
0.751 | 0.155 | -3 | 0.896 |
PDHK3_TYR |
0.751 | 0.116 | 4 | 0.878 |
TESK1_TYR |
0.746 | 0.040 | 3 | 0.926 |
PKMYT1_TYR |
0.746 | 0.126 | 3 | 0.900 |
CK2A1 |
0.744 | -0.121 | 1 | 0.134 |
PLK2 |
0.742 | -0.140 | -3 | 0.745 |
LIMK1_TYR |
0.739 | 0.035 | 2 | 0.855 |
MAP2K4_TYR |
0.739 | -0.026 | -1 | 0.892 |
PDHK4_TYR |
0.738 | 0.003 | 2 | 0.845 |
MAP2K7_TYR |
0.738 | -0.092 | 2 | 0.851 |
MAP2K6_TYR |
0.737 | -0.008 | -1 | 0.901 |
PINK1_TYR |
0.737 | -0.101 | 1 | 0.240 |
ALPHAK3 |
0.736 | -0.123 | -1 | 0.772 |
STLK3 |
0.736 | -0.188 | 1 | 0.161 |
BMPR2_TYR |
0.734 | -0.008 | -1 | 0.894 |
ROS1 |
0.734 | -0.092 | 3 | 0.851 |
JAK2 |
0.734 | -0.103 | 1 | 0.221 |
MST1R |
0.733 | -0.088 | 3 | 0.869 |
RET |
0.733 | -0.140 | 1 | 0.209 |
CSF1R |
0.732 | -0.075 | 3 | 0.858 |
TYK2 |
0.732 | -0.177 | 1 | 0.198 |
TYRO3 |
0.731 | -0.119 | 3 | 0.872 |
TNNI3K_TYR |
0.731 | -0.017 | 1 | 0.224 |
JAK1 |
0.731 | -0.062 | 1 | 0.193 |
NEK10_TYR |
0.731 | -0.089 | 1 | 0.193 |
PDHK1_TYR |
0.730 | -0.099 | -1 | 0.910 |
JAK3 |
0.730 | -0.100 | 1 | 0.205 |
YANK3 |
0.729 | -0.088 | 2 | 0.384 |
EPHA6 |
0.729 | -0.089 | -1 | 0.882 |
TNK1 |
0.728 | -0.051 | 3 | 0.850 |
DDR1 |
0.727 | -0.107 | 4 | 0.805 |
YES1 |
0.725 | -0.090 | -1 | 0.881 |
TXK |
0.725 | -0.081 | 1 | 0.165 |
TEK |
0.724 | -0.000 | 3 | 0.800 |
LCK |
0.724 | -0.071 | -1 | 0.878 |
EPHB4 |
0.724 | -0.135 | -1 | 0.868 |
FGFR1 |
0.724 | -0.037 | 3 | 0.812 |
ABL2 |
0.723 | -0.118 | -1 | 0.821 |
FGFR2 |
0.722 | -0.059 | 3 | 0.828 |
TNK2 |
0.722 | -0.108 | 3 | 0.811 |
HCK |
0.721 | -0.121 | -1 | 0.874 |
BLK |
0.721 | -0.062 | -1 | 0.879 |
ABL1 |
0.721 | -0.118 | -1 | 0.813 |
FGR |
0.720 | -0.171 | 1 | 0.178 |
INSRR |
0.720 | -0.133 | 3 | 0.806 |
KDR |
0.719 | -0.086 | 3 | 0.816 |
ITK |
0.719 | -0.131 | -1 | 0.844 |
PDGFRB |
0.719 | -0.186 | 3 | 0.866 |
FLT3 |
0.718 | -0.161 | 3 | 0.863 |
KIT |
0.717 | -0.136 | 3 | 0.849 |
PDGFRA |
0.715 | -0.186 | 3 | 0.872 |
AXL |
0.715 | -0.160 | 3 | 0.827 |
WEE1_TYR |
0.714 | -0.074 | -1 | 0.776 |
DDR2 |
0.714 | -0.030 | 3 | 0.785 |
FER |
0.714 | -0.215 | 1 | 0.185 |
CK1A |
0.714 | -0.089 | -3 | 0.381 |
EPHB1 |
0.712 | -0.189 | 1 | 0.166 |
MERTK |
0.712 | -0.155 | 3 | 0.824 |
EPHA4 |
0.712 | -0.125 | 2 | 0.748 |
MET |
0.712 | -0.126 | 3 | 0.840 |
EPHB3 |
0.711 | -0.177 | -1 | 0.858 |
SRMS |
0.711 | -0.195 | 1 | 0.159 |
EPHB2 |
0.711 | -0.162 | -1 | 0.851 |
FYN |
0.710 | -0.080 | -1 | 0.862 |
BTK |
0.710 | -0.191 | -1 | 0.806 |
FGFR3 |
0.710 | -0.078 | 3 | 0.802 |
BMX |
0.709 | -0.121 | -1 | 0.758 |
ALK |
0.709 | -0.163 | 3 | 0.776 |
FRK |
0.708 | -0.142 | -1 | 0.872 |
TEC |
0.708 | -0.150 | -1 | 0.769 |
EPHA1 |
0.707 | -0.154 | 3 | 0.815 |
INSR |
0.706 | -0.158 | 3 | 0.796 |
FLT4 |
0.705 | -0.153 | 3 | 0.801 |
NTRK2 |
0.705 | -0.201 | 3 | 0.808 |
MUSK |
0.704 | -0.116 | 1 | 0.142 |
LTK |
0.704 | -0.177 | 3 | 0.791 |
ERBB2 |
0.704 | -0.178 | 1 | 0.179 |
FLT1 |
0.703 | -0.154 | -1 | 0.838 |
LYN |
0.703 | -0.140 | 3 | 0.781 |
EPHA7 |
0.703 | -0.153 | 2 | 0.757 |
PTK2B |
0.702 | -0.125 | -1 | 0.810 |
NTRK1 |
0.702 | -0.228 | -1 | 0.837 |
SRC |
0.701 | -0.118 | -1 | 0.847 |
PTK6 |
0.700 | -0.224 | -1 | 0.751 |
NTRK3 |
0.699 | -0.171 | -1 | 0.790 |
EPHA3 |
0.698 | -0.173 | 2 | 0.728 |
EGFR |
0.698 | -0.130 | 1 | 0.155 |
EPHA8 |
0.694 | -0.142 | -1 | 0.840 |
MATK |
0.694 | -0.129 | -1 | 0.735 |
YANK2 |
0.693 | -0.112 | 2 | 0.397 |
CK1G3 |
0.692 | -0.095 | -3 | 0.333 |
EPHA5 |
0.691 | -0.178 | 2 | 0.737 |
FGFR4 |
0.691 | -0.136 | -1 | 0.773 |
CSK |
0.690 | -0.180 | 2 | 0.764 |
PTK2 |
0.688 | -0.083 | -1 | 0.814 |
ERBB4 |
0.688 | -0.105 | 1 | 0.151 |
IGF1R |
0.686 | -0.162 | 3 | 0.728 |
SYK |
0.684 | -0.116 | -1 | 0.798 |
EPHA2 |
0.682 | -0.159 | -1 | 0.797 |
ZAP70 |
0.675 | -0.083 | -1 | 0.723 |
FES |
0.672 | -0.165 | -1 | 0.728 |
CK1G2 |
0.670 | -0.097 | -3 | 0.428 |