Motif 1028 (n=233)

Position-wise Probabilities

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uniprot	genes	site	source	protein	function
A0A0C4DFX4	None	T237	ochoa	Snf2 related CREBBP activator protein	None
A0A0C4DFX4	None	T2607	ochoa	Snf2 related CREBBP activator protein	None
A0MZ66	SHTN1	T475	ochoa	Shootin-1 (Shootin1)	Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250\|UniProtKB:A0MZ67, ECO:0000250\|UniProtKB:Q8K2Q9}.
A0MZ66	SHTN1	T487	ochoa	Shootin-1 (Shootin1)	Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. {ECO:0000250\|UniProtKB:A0MZ67, ECO:0000250\|UniProtKB:Q8K2Q9}.
A6H8Y1	BDP1	T2432	ochoa	Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator)	General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269\|PubMed:11040218}.
A6NKT7	RGPD3	T1566	ochoa	RanBP2-like and GRIP domain-containing protein 3	None
A8MVS5	HIDE1	T198	ochoa	Protein HIDE1	None
O14497	ARID1A	T286	ochoa	AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250\|UniProtKB:A2BH40, ECO:0000303\|PubMed:12672490, ECO:0000303\|PubMed:22952240, ECO:0000303\|PubMed:26601204}.
O14641	DVL2	T125	ochoa	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)	Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250\|UniProtKB:Q60838, ECO:0000269\|PubMed:19252499, ECO:0000269\|PubMed:24616100}.
O14715	RGPD8	T1565	ochoa	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)	None
O14976	GAK	T761	ochoa	Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26)	Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (PubMed:10625686). May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly (PubMed:18489706). {ECO:0000269\|PubMed:10625686, ECO:0000269\|PubMed:18489706}.
O15085	ARHGEF11	T1461	ochoa	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269\|PubMed:21670212}.
O15211	RGL2	T738	ochoa	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)	Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}.
O15516	CLOCK	T443	ochoa	Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK\|NPAS2-BMAL1\|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region (PubMed:21980503). The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (PubMed:28985504). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity). {ECO:0000250\|UniProtKB:O08785, ECO:0000269\|PubMed:14645221, ECO:0000269\|PubMed:18587630, ECO:0000269\|PubMed:21659603, ECO:0000269\|PubMed:21980503, ECO:0000269\|PubMed:22284746, ECO:0000269\|PubMed:23229515, ECO:0000269\|PubMed:23785138, ECO:0000269\|PubMed:24005054, ECO:0000269\|PubMed:28985504}.
O60566	BUB1B	T680	ochoa\|psp	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)	Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269\|PubMed:10477750, ECO:0000269\|PubMed:11702782, ECO:0000269\|PubMed:14706340, ECO:0000269\|PubMed:15020684, ECO:0000269\|PubMed:19411850, ECO:0000269\|PubMed:19503101}.
O75122	CLASP2	T1010	ochoa	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2)	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269\|PubMed:11290329, ECO:0000269\|PubMed:15631994, ECO:0000269\|PubMed:16824950, ECO:0000269\|PubMed:16866869, ECO:0000269\|PubMed:16914514, ECO:0000269\|PubMed:17543864, ECO:0000269\|PubMed:20937854, ECO:0000269\|PubMed:26003921}.
O75410	TACC1	T250	ochoa	Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)	Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269\|PubMed:20078863}.
O75533	SF3B1	T56	ochoa	Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)	Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B1 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). {ECO:0000250\|UniProtKB:Q99NB9, ECO:0000269\|PubMed:10882114, ECO:0000269\|PubMed:12234937, ECO:0000269\|PubMed:15146077, ECO:0000269\|PubMed:27720643, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:33509932, ECO:0000269\|PubMed:34822310}.
O95251	KAT7	T85	ochoa\|psp	Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)	Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250\|UniProtKB:Q5SVQ0, ECO:0000269\|PubMed:10438470, ECO:0000269\|PubMed:11278932, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:16997280, ECO:0000269\|PubMed:18832067, ECO:0000269\|PubMed:19187766, ECO:0000269\|PubMed:20129055, ECO:0000269\|PubMed:21753189, ECO:0000269\|PubMed:21856198, ECO:0000269\|PubMed:24065767, ECO:0000269\|PubMed:26620551, ECO:0000269\|PubMed:27270040, ECO:0000269\|PubMed:28719581, ECO:0000269\|PubMed:31767635, ECO:0000269\|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269\|PubMed:31827282}.
O95251	KAT7	T118	ochoa	Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)	Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250\|UniProtKB:Q5SVQ0, ECO:0000269\|PubMed:10438470, ECO:0000269\|PubMed:11278932, ECO:0000269\|PubMed:16387653, ECO:0000269\|PubMed:16997280, ECO:0000269\|PubMed:18832067, ECO:0000269\|PubMed:19187766, ECO:0000269\|PubMed:20129055, ECO:0000269\|PubMed:21753189, ECO:0000269\|PubMed:21856198, ECO:0000269\|PubMed:24065767, ECO:0000269\|PubMed:26620551, ECO:0000269\|PubMed:27270040, ECO:0000269\|PubMed:28719581, ECO:0000269\|PubMed:31767635, ECO:0000269\|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269\|PubMed:31827282}.
O95359	TACC2	T2373	ochoa	Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1)	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. {ECO:0000250, ECO:0000269\|PubMed:10749935}.
P02545	LMNA	T409	ochoa	Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]	[Lamin-A/C]: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:2188730, PubMed:22431096, PubMed:2344612, PubMed:23666920, PubMed:24741066, PubMed:31434876, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:24741066, PubMed:31548606, PubMed:37788673, PubMed:37832547). Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:2188730, PubMed:2344612). Lamin A and C are present in equal amounts in the lamina of mammals (PubMed:10080180, PubMed:10580070, PubMed:10587585, PubMed:10814726, PubMed:11799477, PubMed:12075506, PubMed:12927431, PubMed:15317753, PubMed:18551513, PubMed:18611980, PubMed:22431096, PubMed:23666920, PubMed:31548606). Also invoved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:10814726, PubMed:11799477, PubMed:18551513, PubMed:22431096). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269\|PubMed:10080180, ECO:0000269\|PubMed:10580070, ECO:0000269\|PubMed:10587585, ECO:0000269\|PubMed:10814726, ECO:0000269\|PubMed:11799477, ECO:0000269\|PubMed:12075506, ECO:0000269\|PubMed:12927431, ECO:0000269\|PubMed:15317753, ECO:0000269\|PubMed:18551513, ECO:0000269\|PubMed:18611980, ECO:0000269\|PubMed:2188730, ECO:0000269\|PubMed:22431096, ECO:0000269\|PubMed:2344612, ECO:0000269\|PubMed:23666920, ECO:0000269\|PubMed:23990565, ECO:0000269\|PubMed:24741066, ECO:0000269\|PubMed:25127216, ECO:0000269\|PubMed:31434876, ECO:0000269\|PubMed:31548606, ECO:0000269\|PubMed:37788673, ECO:0000269\|PubMed:37832547}.; FUNCTION: [Prelamin-A/C]: Prelamin-A/C can accelerate smooth muscle cell senescence (PubMed:20458013). It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (PubMed:20458013). {ECO:0000269\|PubMed:20458013}.
P02671	FGA	T555	ochoa	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250\|UniProtKB:E9PV24}.
P04075	ALDOA	T255	ochoa	Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)	Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity). {ECO:0000250, ECO:0000269\|PubMed:14766013}.
P04083	ANXA1	T172	ochoa	Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]	Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). {ECO:0000250\|UniProtKB:P10107, ECO:0000250\|UniProtKB:P19619, ECO:0000269\|PubMed:17008549, ECO:0000269\|PubMed:19625660, ECO:0000269\|PubMed:2532504, ECO:0000269\|PubMed:2936963, ECO:0000269\|PubMed:8425544, ECO:0000269\|PubMed:8557678}.; FUNCTION: [Annexin Ac2-26]: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). {ECO:0000269\|PubMed:15187149, ECO:0000269\|PubMed:22879591, ECO:0000269\|PubMed:25664854}.
P05783	KRT18	Y36	ochoa	Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269\|PubMed:15529338, ECO:0000269\|PubMed:16424149, ECO:0000269\|PubMed:17213200, ECO:0000269\|PubMed:7523419, ECO:0000269\|PubMed:8522591, ECO:0000269\|PubMed:9298992, ECO:0000269\|PubMed:9524113}.
P09661	SNRPA1	T180	ochoa	U2 small nuclear ribonucleoprotein A' (U2 snRNP A')	Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:27035939, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:27035939, PubMed:32494006, PubMed:9716128). {ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:27035939, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:28781166, ECO:0000269\|PubMed:32494006, ECO:0000269\|PubMed:9716128}.
P10636	MAPT	T498	ochoa\|psp	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269\|PubMed:21985311, ECO:0000269\|PubMed:32961270}.
P11171	EPB41	T534	ochoa	Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)	Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269\|PubMed:23870127}.
P15336	ATF2	T323	ochoa	Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)	Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269\|PubMed:10821277, ECO:0000269\|PubMed:15916964, ECO:0000269\|PubMed:18397884, ECO:0000269\|PubMed:22304920}.
P19634	SLC9A1	T779	ochoa\|psp	Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)	Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubMed:14680478, PubMed:15035633, PubMed:15677483, PubMed:17073455, PubMed:17493937, PubMed:22020933, PubMed:27650500, PubMed:32130622, PubMed:7110335, PubMed:7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, PubMed:8901634). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed:15096511). {ECO:0000250\|UniProtKB:P26431, ECO:0000269\|PubMed:11350981, ECO:0000269\|PubMed:11532004, ECO:0000269\|PubMed:12947095, ECO:0000269\|PubMed:14680478, ECO:0000269\|PubMed:15035633, ECO:0000269\|PubMed:15096511, ECO:0000269\|PubMed:15677483, ECO:0000269\|PubMed:17073455, ECO:0000269\|PubMed:17493937, ECO:0000269\|PubMed:22020933, ECO:0000269\|PubMed:27650500, ECO:0000269\|PubMed:32130622, ECO:0000269\|PubMed:7110335, ECO:0000269\|PubMed:7603840, ECO:0000269\|PubMed:8901634}.
P20810	CAST	T546	ochoa	Calpastatin (Calpain inhibitor) (Sperm BS-17 component)	Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
P23588	EIF4B	T54	ochoa	Eukaryotic translation initiation factor 4B (eIF-4B)	Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
P25054	APC	T1847	ochoa	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton (PubMed:17293347). Plays a role in mediating the organization of F-actin into ordered bundles (PubMed:17293347). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000250\|UniProtKB:Q61315, ECO:0000269\|PubMed:10947987, ECO:0000269\|PubMed:17293347, ECO:0000269\|PubMed:17599059, ECO:0000269\|PubMed:19151759, ECO:0000269\|PubMed:19893577, ECO:0000269\|PubMed:20937854}.
P27816	MAP4	T810	ochoa	Microtubule-associated protein 4 (MAP-4)	Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269\|PubMed:10791892, ECO:0000269\|PubMed:34782749}.
P28715	ERCC5	T338	ochoa	DNA excision repair protein ERCC-5 (EC 3.1.-.-) (DNA repair protein complementing XP-G cells) (XPG) (Xeroderma pigmentosum group G-complementing protein)	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair (PubMed:32522879, PubMed:32821917, PubMed:7651464, PubMed:8078765, PubMed:8090225, PubMed:8206890). Makes the 3'incision in DNA nucleotide excision repair (NER) (PubMed:32522879, PubMed:32821917, PubMed:8078765, PubMed:8090225). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble (PubMed:32522879). Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA (PubMed:9927729). Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (PubMed:16246722). Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II (PubMed:16246722). Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity (PubMed:16246722). Required for DNA replication fork maintenance and preservation of genomic stability (PubMed:26833090, PubMed:32522879). Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site (PubMed:26833090). In TFIIH stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3 (PubMed:31253769). During HRR, binds to the replication fork with high specificity and stabilizes it (PubMed:32522879). Also, acts upstream of HRR, to promote the release of BRCA1 from DNA (PubMed:26833090). {ECO:0000269\|PubMed:16246722, ECO:0000269\|PubMed:26833090, ECO:0000269\|PubMed:31253769, ECO:0000269\|PubMed:32522879, ECO:0000269\|PubMed:32821917, ECO:0000269\|PubMed:7651464, ECO:0000269\|PubMed:8078765, ECO:0000269\|PubMed:8090225, ECO:0000269\|PubMed:8206890, ECO:0000269\|PubMed:9927729}.
P30260	CDC27	T205	ochoa	Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). {ECO:0000269\|PubMed:18485873, ECO:0000269\|PubMed:29033132}.
P30622	CLIP1	T287	ochoa\|psp	CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin)	Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269\|PubMed:12433698, ECO:0000269\|PubMed:17563362, ECO:0000269\|PubMed:17889670}.
P35348	ADRA1A	T384	psp	Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c)	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269\|PubMed:18802028, ECO:0000269\|PubMed:22120526}.
P35568	IRS1	T446	ochoa\|psp	Insulin receptor substrate 1 (IRS-1)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:19639489). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:11171109, PubMed:8265614). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:11171109, ECO:0000269\|PubMed:16878150, ECO:0000269\|PubMed:19639489, ECO:0000269\|PubMed:38625937, ECO:0000269\|PubMed:7541045, ECO:0000269\|PubMed:8265614}.
P38159	RBMX	T297	ochoa	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269\|PubMed:12165565, ECO:0000269\|PubMed:12761049, ECO:0000269\|PubMed:16707624, ECO:0000269\|PubMed:18445477, ECO:0000269\|PubMed:18541147, ECO:0000269\|PubMed:19282290, ECO:0000269\|PubMed:21327109}.
P42166	TMPO	T160	ochoa	Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]	May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
P42695	NCAPD3	T1331	ochoa	Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3)	Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). {ECO:0000269\|PubMed:14532007, ECO:0000269\|PubMed:27737959}.
P46821	MAP1B	T1799	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P46821	MAP1B	T1864	ochoa	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269\|PubMed:18195017, ECO:0000269\|PubMed:33268592}.
P46937	YAP1	T110	ochoa\|psp	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533). {ECO:0000250\|UniProtKB:P46938, ECO:0000269\|PubMed:16772533, ECO:0000269\|PubMed:17974916, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:18280240, ECO:0000269\|PubMed:18579750, ECO:0000269\|PubMed:21364637, ECO:0000269\|PubMed:25778702, ECO:0000269\|PubMed:25849865, ECO:0000269\|PubMed:26598551, ECO:0000269\|PubMed:30447097, ECO:0000269\|PubMed:34404733}.; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269\|PubMed:12807903}.
P48681	NES	T338	ochoa	Nestin	Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). {ECO:0000250}.
P49023	PXN	T255	ochoa	Paxillin	Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000269\|PubMed:25015296}.
P49757	NUMB	T235	ochoa	Protein numb homolog (h-Numb) (Protein S171)	Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250\|UniProtKB:Q9QZS3, ECO:0000269\|PubMed:18657069}.
P49792	RANBP2	T1497	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P49792	RANBP2	T2541	ochoa	E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)	E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269\|PubMed:11792325, ECO:0000269\|PubMed:12032081, ECO:0000269\|PubMed:15378033, ECO:0000269\|PubMed:15931224, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:22155184, ECO:0000269\|PubMed:22194619, ECO:0000269\|PubMed:22902403, ECO:0000269\|PubMed:23353830, ECO:0000269\|PubMed:7775481, ECO:0000303\|PubMed:10078529}.
P50851	LRBA	T976	ochoa	Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)	Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria (PubMed:33773106). {ECO:0000250\|UniProtKB:Q9ESE1, ECO:0000269\|PubMed:33773106}.
P52948	NUP98	T915	ochoa	Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269\|PubMed:23523133}.
P52948	NUP98	T1022	ochoa	Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]	Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) (PubMed:23523133). {ECO:0000269\|PubMed:23523133}.
P53814	SMTN	T351	ochoa	Smoothelin	Structural protein of the cytoskeleton.
P54253	ATXN1	T235	ochoa\|psp	Ataxin-1 (Spinocerebellar ataxia type 1 protein)	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity). {ECO:0000250\|UniProtKB:P54254, ECO:0000269\|PubMed:21475249}.
P55265	ADAR	T808	ochoa	Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP)	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12618436, PubMed:7565688, PubMed:7972084). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins since the translational machinery read the inosine as a guanosine; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. {ECO:0000269\|PubMed:12618436, ECO:0000269\|PubMed:15556947, ECO:0000269\|PubMed:15858013, ECO:0000269\|PubMed:16120648, ECO:0000269\|PubMed:16475990, ECO:0000269\|PubMed:17079286, ECO:0000269\|PubMed:19605474, ECO:0000269\|PubMed:19651874, ECO:0000269\|PubMed:19710021, ECO:0000269\|PubMed:19908260, ECO:0000269\|PubMed:21289159, ECO:0000269\|PubMed:22278222, ECO:0000269\|PubMed:7565688, ECO:0000269\|PubMed:7972084}.
P55957	BID	T59	ochoa\|psp	BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]	Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity). {ECO:0000250\|UniProtKB:P70444, ECO:0000269\|PubMed:14583606}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Allows the release of cytochrome c (PubMed:32029622). {ECO:0000269\|PubMed:15661737, ECO:0000269\|PubMed:32029622}.; FUNCTION: [Isoform 1]: Induces ICE-like proteases and apoptosis. {ECO:0000269\|PubMed:14583606}.; FUNCTION: [Isoform 2]: Induces ICE-like proteases and apoptosis. {ECO:0000269\|PubMed:14583606}.; FUNCTION: [Isoform 3]: Does not induce apoptosis. {ECO:0000269\|PubMed:14583606}.; FUNCTION: [Isoform 4]: Induces ICE-like proteases and apoptosis. {ECO:0000269\|PubMed:14583606}.
P62805	H4C1	T31	ochoa	Histone H4	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P78527	PRKDC	T2638	ochoa\|psp	DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460)	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250\|UniProtKB:P97313, ECO:0000269\|PubMed:10026262, ECO:0000269\|PubMed:10467406, ECO:0000269\|PubMed:11889123, ECO:0000269\|PubMed:11955432, ECO:0000269\|PubMed:12509254, ECO:0000269\|PubMed:12649176, ECO:0000269\|PubMed:14599745, ECO:0000269\|PubMed:14612514, ECO:0000269\|PubMed:14627815, ECO:0000269\|PubMed:14704337, ECO:0000269\|PubMed:14734805, ECO:0000269\|PubMed:15177042, ECO:0000269\|PubMed:15262962, ECO:0000269\|PubMed:15574326, ECO:0000269\|PubMed:1597196, ECO:0000269\|PubMed:16046194, ECO:0000269\|PubMed:16397295, ECO:0000269\|PubMed:18644470, ECO:0000269\|PubMed:2247066, ECO:0000269\|PubMed:2507541, ECO:0000269\|PubMed:26237645, ECO:0000269\|PubMed:26666690, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:29478807, ECO:0000269\|PubMed:30247612, ECO:0000269\|PubMed:32103174, ECO:0000269\|PubMed:33273464, ECO:0000269\|PubMed:33854234, ECO:0000269\|PubMed:34352203, ECO:0000269\|PubMed:35460603, ECO:0000269\|PubMed:8407951, ECO:0000269\|PubMed:8464713, ECO:0000269\|PubMed:9139719, ECO:0000269\|PubMed:9362500, ECO:0000269\|PubMed:9363941, ECO:0000269\|PubMed:9679063}.
P78527	PRKDC	T3198	ochoa	DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (Ser-473 kinase) (S473K) (p460)	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Acts as a regulator of the phosphatidylinositol 3-kinase/protein kinase B signal transduction by mediating phosphorylation of 'Ser-473' of protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), promoting their activation (PubMed:15262962). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603). {ECO:0000250\|UniProtKB:P97313, ECO:0000269\|PubMed:10026262, ECO:0000269\|PubMed:10467406, ECO:0000269\|PubMed:11889123, ECO:0000269\|PubMed:11955432, ECO:0000269\|PubMed:12509254, ECO:0000269\|PubMed:12649176, ECO:0000269\|PubMed:14599745, ECO:0000269\|PubMed:14612514, ECO:0000269\|PubMed:14627815, ECO:0000269\|PubMed:14704337, ECO:0000269\|PubMed:14734805, ECO:0000269\|PubMed:15177042, ECO:0000269\|PubMed:15262962, ECO:0000269\|PubMed:15574326, ECO:0000269\|PubMed:1597196, ECO:0000269\|PubMed:16046194, ECO:0000269\|PubMed:16397295, ECO:0000269\|PubMed:18644470, ECO:0000269\|PubMed:2247066, ECO:0000269\|PubMed:2507541, ECO:0000269\|PubMed:26237645, ECO:0000269\|PubMed:26666690, ECO:0000269\|PubMed:28712728, ECO:0000269\|PubMed:29478807, ECO:0000269\|PubMed:30247612, ECO:0000269\|PubMed:32103174, ECO:0000269\|PubMed:33273464, ECO:0000269\|PubMed:33854234, ECO:0000269\|PubMed:34352203, ECO:0000269\|PubMed:35460603, ECO:0000269\|PubMed:8407951, ECO:0000269\|PubMed:8464713, ECO:0000269\|PubMed:9139719, ECO:0000269\|PubMed:9362500, ECO:0000269\|PubMed:9363941, ECO:0000269\|PubMed:9679063}.
P98082	DAB2	T245	ochoa	Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)	Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269\|PubMed:11387212, ECO:0000269\|PubMed:12805222, ECO:0000269\|PubMed:16267015, ECO:0000269\|PubMed:16984970, ECO:0000269\|PubMed:19306879, ECO:0000269\|PubMed:21995445, ECO:0000269\|PubMed:22323290, ECO:0000269\|PubMed:22491013}.
P98082	DAB2	T307	ochoa	Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)	Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269\|PubMed:11387212, ECO:0000269\|PubMed:12805222, ECO:0000269\|PubMed:16267015, ECO:0000269\|PubMed:16984970, ECO:0000269\|PubMed:19306879, ECO:0000269\|PubMed:21995445, ECO:0000269\|PubMed:22323290, ECO:0000269\|PubMed:22491013}.
Q01082	SPTBN1	T2155	ochoa	Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)	Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. {ECO:0000269\|PubMed:34211179}.
Q01484	ANK2	T3775	ochoa	Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)	Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250\|UniProtKB:Q8C8R3, ECO:0000269\|PubMed:12571597}.
Q02952	AKAP12	T548	ochoa	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Q03164	KMT2A	T506	ochoa	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:24235145, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:12453419, PubMed:15960975, PubMed:19187761, PubMed:19556245, PubMed:20677832, PubMed:21220120, PubMed:25561738, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20010842, PubMed:20677832). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.
Q08357	SLC20A2	T390	ochoa	Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2)	Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). {ECO:0000250\|UniProtKB:Q80UP8, ECO:0000269\|PubMed:12205090, ECO:0000269\|PubMed:15955065, ECO:0000269\|PubMed:16790504, ECO:0000269\|PubMed:17494632, ECO:0000269\|PubMed:22327515, ECO:0000269\|PubMed:28722801, ECO:0000269\|PubMed:30704756}.; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. {ECO:0000269\|PubMed:11435563, ECO:0000269\|PubMed:12205090, ECO:0000269\|PubMed:15955065, ECO:0000269\|PubMed:8302848}.
Q08999	RBL2	T954	ochoa	Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Q08AD1	CAMSAP2	T1002	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q08AD1	CAMSAP2	T1004	ochoa	Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)	Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.
Q09666	AHNAK	T553	ochoa	Neuroblast differentiation-associated protein AHNAK (Desmoyokin)	May be required for neuronal cell differentiation.
Q10570	CPSF1	T736	ochoa	Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). {ECO:0000250\|UniProtKB:A0A0R4IC37, ECO:0000269\|PubMed:14749727}.
Q12774	ARHGEF5	T645	ochoa	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity). {ECO:0000250\|UniProtKB:E9Q7D5, ECO:0000269\|PubMed:14662653, ECO:0000269\|PubMed:15601624}.
Q12802	AKAP13	T1887	ochoa	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250\|UniProtKB:E9Q394, ECO:0000269\|PubMed:11546812, ECO:0000269\|PubMed:11579095, ECO:0000269\|PubMed:17537920, ECO:0000269\|PubMed:21224381, ECO:0000269\|PubMed:23716597, ECO:0000269\|PubMed:24993829, ECO:0000269\|PubMed:25186459, ECO:0000269\|PubMed:9627117, ECO:0000269\|PubMed:9891067}.
Q12888	TP53BP1	T1648	ochoa\|psp	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:17190600, PubMed:21144835, PubMed:22553214, PubMed:23333306, PubMed:27153538, PubMed:28241136, PubMed:31135337, PubMed:37696958). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23333306, PubMed:23727112, PubMed:27153538, PubMed:31135337). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:17190600, PubMed:23760478, PubMed:27153538, PubMed:28241136). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250\|UniProtKB:P70399, ECO:0000269\|PubMed:12364621, ECO:0000269\|PubMed:17190600, ECO:0000269\|PubMed:21144835, ECO:0000269\|PubMed:22553214, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:23345425, ECO:0000269\|PubMed:23727112, ECO:0000269\|PubMed:23760478, ECO:0000269\|PubMed:27153538, ECO:0000269\|PubMed:28241136, ECO:0000269\|PubMed:31135337, ECO:0000269\|PubMed:37696958}.
Q12929	EPS8	Y485	ochoa\|psp	Epidermal growth factor receptor kinase substrate 8	Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269\|PubMed:15558031, ECO:0000269\|PubMed:17115031}.
Q12959	DLG1	T126	ochoa	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)	Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250\|UniProtKB:A0A8C0TYJ0, ECO:0000250\|UniProtKB:Q811D0, ECO:0000269\|PubMed:10656683, ECO:0000269\|PubMed:12445884, ECO:0000269\|PubMed:14699157, ECO:0000269\|PubMed:15263016, ECO:0000269\|PubMed:19213956, ECO:0000269\|PubMed:20605917, ECO:0000269\|PubMed:23676497}.
Q13424	SNTA1	T183	ochoa	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)	Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}.
Q13427	PPIG	T358	ochoa	Peptidyl-prolyl cis-trans isomerase G (PPIase G) (Peptidyl-prolyl isomerase G) (EC 5.2.1.8) (CASP10) (Clk-associating RS-cyclophilin) (CARS-Cyp) (CARS-cyclophilin) (SR-cyclophilin) (SR-cyp) (SRcyp) (Cyclophilin G) (Rotamase G)	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. {ECO:0000269\|PubMed:20676357}.
Q13428	TCOF1	T147	ochoa	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q13439	GOLGA4	T31	ochoa	Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230)	Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269\|PubMed:15265687, ECO:0000269\|PubMed:29084197}.
Q13480	GAB1	Y259	ochoa\|psp	GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)	Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269\|PubMed:29408807}.
Q13541	EIF4EBP1	T68	ochoa	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. {ECO:0000269\|PubMed:22578813, ECO:0000269\|PubMed:22684010, ECO:0000269\|PubMed:7935836}.
Q13761	RUNX3	T209	psp	Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)	Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Necessary for the development and survival of sensory neurons expressing parvalbumin (By similarity). {ECO:0000250\|UniProtKB:Q64131, ECO:0000269\|PubMed:20599712}.
Q13835	PKP1	T171	psp	Plakophilin-1 (Band 6 protein) (B6P)	A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:23444369). Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments (PubMed:10852826, PubMed:23444369). Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG (PubMed:31835537). Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions (By similarity). Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes (By similarity). Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes (By similarity). May also promote keratinocyte proliferation and morphogenesis during postnatal development (PubMed:9326952). Required for tight junction inside-out transepidermal barrier function of the skin (By similarity). Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions (By similarity). Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival (PubMed:20613778). Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity (PubMed:20156963, PubMed:23444369). Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1 (PubMed:25225333). {ECO:0000250\|UniProtKB:P97350, ECO:0000269\|PubMed:10852826, ECO:0000269\|PubMed:20156963, ECO:0000269\|PubMed:20613778, ECO:0000269\|PubMed:23444369, ECO:0000269\|PubMed:25225333, ECO:0000269\|PubMed:31835537, ECO:0000269\|PubMed:9326952}.
Q14181	POLA2	T130	ochoa	DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)	Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250\|UniProtKB:P09884, ECO:0000250\|UniProtKB:P20664, ECO:0000269\|PubMed:9705292}.
Q14451	GRB7	T62	ochoa	Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)	Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269\|PubMed:10893408, ECO:0000269\|PubMed:12021278, ECO:0000269\|PubMed:12223469, ECO:0000269\|PubMed:20622016}.
Q14677	CLINT1	T306	ochoa	Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)	Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269\|PubMed:12429846, ECO:0000269\|PubMed:12538641}.
Q14938	NFIX	T233	ochoa	Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein)	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Q15052	ARHGEF6	T133	ochoa	Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)	Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Q15149	PLEC	T4367	ochoa	Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)	Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:21109228}.
Q15149	PLEC	T4653	ochoa	Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)	Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269\|PubMed:12482924, ECO:0000269\|PubMed:21109228}.
Q15555	MAPRE2	T202	ochoa	Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)	Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250\|UniProtKB:Q8R001, ECO:0000269\|PubMed:22373814, ECO:0000269\|PubMed:23844040, ECO:0000269\|PubMed:26527684, ECO:0000269\|PubMed:27030108}.
Q15555	MAPRE2	T217	ochoa	Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)	Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684). {ECO:0000250\|UniProtKB:Q8R001, ECO:0000269\|PubMed:22373814, ECO:0000269\|PubMed:23844040, ECO:0000269\|PubMed:26527684, ECO:0000269\|PubMed:27030108}.
Q15678	PTPN14	T577	ochoa	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)	Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269\|PubMed:10934049, ECO:0000269\|PubMed:12808048, ECO:0000269\|PubMed:17893246, ECO:0000269\|PubMed:20826270, ECO:0000269\|PubMed:22233626, ECO:0000269\|PubMed:22525271, ECO:0000269\|PubMed:22948661}.
Q15751	HERC1	T1493	ochoa	Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)	Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269\|PubMed:15642342, ECO:0000269\|PubMed:8861955, ECO:0000269\|PubMed:9233772}.
Q16204	CCDC6	T357	ochoa	Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)	None
Q27J81	INF2	T1187	ochoa	Inverted formin-2 (HBEBP2-binding protein C)	Severs actin filaments and accelerates their polymerization and depolymerization. {ECO:0000250}.
Q2M2I8	AAK1	T673	ochoa	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)	Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269\|PubMed:11877457, ECO:0000269\|PubMed:11877461, ECO:0000269\|PubMed:12952931, ECO:0000269\|PubMed:14617351, ECO:0000269\|PubMed:17494869, ECO:0000269\|PubMed:18657069, ECO:0000269\|PubMed:21464124, ECO:0000269\|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269\|PubMed:25653444, ECO:0000305\|PubMed:31136173}.
Q2TB10	ZNF800	T319	ochoa	Zinc finger protein 800	May be involved in transcriptional regulation.
Q32P44	EML3	T187	ochoa	Echinoderm microtubule-associated protein-like 3 (EMAP-3)	Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (PubMed:30723163). Required for proper alignnment of chromosomes during metaphase (PubMed:18445686). {ECO:0000269\|PubMed:18445686, ECO:0000269\|PubMed:30723163}.
Q4L180	FILIP1L	T994	ochoa	Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)	Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. {ECO:0000269\|PubMed:18794120}.
Q5QJE6	DNTTIP2	T131	ochoa	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269\|PubMed:12786946, ECO:0000269\|PubMed:15047147, ECO:0000269\|PubMed:34516797}.
Q5QJE6	DNTTIP2	T172	ochoa	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269\|PubMed:12786946, ECO:0000269\|PubMed:15047147, ECO:0000269\|PubMed:34516797}.
Q5T200	ZC3H13	T364	ochoa	Zinc finger CCCH domain-containing protein 13	Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity). {ECO:0000250\|UniProtKB:E9Q784}.
Q5UIP0	RIF1	T1776	ochoa	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). {ECO:0000250\|UniProtKB:Q6PR54, ECO:0000269\|PubMed:15342490, ECO:0000269\|PubMed:23333306, ECO:0000269\|PubMed:28241136}.
Q63HQ0	AP1AR	T181	ochoa	AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin)	Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269\|PubMed:15775984, ECO:0000269\|PubMed:19706427, ECO:0000269\|PubMed:21525240, ECO:0000269\|PubMed:22689987}.
Q658Y4	FAM91A1	T349	ochoa	Protein FAM91A1	As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. {ECO:0000269\|PubMed:29426865}.
Q674X7	KAZN	T333	ochoa	Kazrin	Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269\|PubMed:15337775}.
Q6IQ26	DENND5A	T1079	ochoa	DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1)	Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250\|UniProtKB:G3V7Q0, ECO:0000269\|PubMed:20937701}.
Q6P4F7	ARHGAP11A	T323	ochoa	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000269\|PubMed:27957544}.
Q6VY07	PACS1	T413	ochoa	Phosphofurin acidic cluster sorting protein 1 (PACS-1)	Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity). {ECO:0000250\|UniProtKB:Q8K212, ECO:0000269\|PubMed:11331585, ECO:0000269\|PubMed:15692563}.
Q6ZRS2	SRCAP	T256	ochoa	Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269\|PubMed:10347196, ECO:0000269\|PubMed:11522779, ECO:0000269\|PubMed:14500758, ECO:0000269\|PubMed:16024792, ECO:0000269\|PubMed:16634648, ECO:0000269\|PubMed:17617668}.
Q6ZRS2	SRCAP	T2784	ochoa	Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269\|PubMed:10347196, ECO:0000269\|PubMed:11522779, ECO:0000269\|PubMed:14500758, ECO:0000269\|PubMed:16024792, ECO:0000269\|PubMed:16634648, ECO:0000269\|PubMed:17617668}.
Q6ZRV2	FAM83H	Y908	ochoa	Protein FAM83H	May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). {ECO:0000269\|PubMed:18252228, ECO:0000269\|PubMed:23902688}.
Q6ZUJ8	PIK3AP1	T722	ochoa	Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)	Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269\|PubMed:15893754}.
Q7KZI7	MARK2	T469	ochoa	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)	Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269\|PubMed:11433294, ECO:0000269\|PubMed:12429843, ECO:0000269\|PubMed:14976552, ECO:0000269\|PubMed:15158914, ECO:0000269\|PubMed:15324659, ECO:0000269\|PubMed:15365179, ECO:0000269\|PubMed:16775013, ECO:0000269\|PubMed:16980613, ECO:0000269\|PubMed:18626018, ECO:0000269\|PubMed:20194617, ECO:0000269\|PubMed:23666762}.
Q7Z2W4	ZC3HAV1	T347	ochoa	Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)	Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269\|PubMed:18225958, ECO:0000269\|PubMed:21102435, ECO:0000269\|PubMed:21876179, ECO:0000269\|PubMed:22720057}.
Q7Z3K6	MIER3	T148	ochoa	Mesoderm induction early response protein 3 (Mi-er3)	Transcriptional repressor. {ECO:0000250}.
Q7Z6I6	ARHGAP30	T1020	ochoa	Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)	GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. {ECO:0000269\|PubMed:21565175}.
Q7Z6Z7	HUWE1	T2529	ochoa	E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250\|UniProtKB:P51593, ECO:0000250\|UniProtKB:Q7TMY8, ECO:0000269\|PubMed:15567145, ECO:0000269\|PubMed:15767685, ECO:0000269\|PubMed:15989956, ECO:0000269\|PubMed:15989957, ECO:0000269\|PubMed:17567951, ECO:0000269\|PubMed:18488021, ECO:0000269\|PubMed:19037095, ECO:0000269\|PubMed:19713937, ECO:0000269\|PubMed:20534529, ECO:0000269\|PubMed:26214738, ECO:0000269\|PubMed:27746020, ECO:0000269\|PubMed:30217973, ECO:0000269\|PubMed:35776542}.
Q86TV6	TTC7B	T661	ochoa	Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1)	Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed:26571211). {ECO:0000269\|PubMed:23229899, ECO:0000269\|PubMed:26571211}.
Q86VP3	PACS2	T690	ochoa	Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)	Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269\|PubMed:15692563, ECO:0000269\|PubMed:15692567}.
Q86YS7	C2CD5	T278	ochoa	C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa)	Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269\|PubMed:21907143}.
Q86YW5	TREML1	T246	ochoa	Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1)	Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269\|PubMed:15128762}.
Q8IV63	VRK3	T119	ochoa	Serine/threonine-protein kinase VRK3 (EC 2.7.11.22) (Vaccinia-related kinase 3)	Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812). {ECO:0000250\|UniProtKB:Q8K3G5, ECO:0000269\|PubMed:14645249, ECO:0000269\|PubMed:19141289, ECO:0000269\|PubMed:25899223, ECO:0000269\|PubMed:27346674, ECO:0000269\|PubMed:27941812}.
Q8IVT2	MISP	T377	ochoa\|psp	Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)	Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269\|PubMed:23509069, ECO:0000269\|PubMed:23574715}.
Q8IWC1	MAP7D3	T492	ochoa	MAP7 domain-containing protein 3	Promotes the assembly and stability of microtubules. {ECO:0000269\|PubMed:22142902, ECO:0000269\|PubMed:24927501}.
Q8IWS0	PHF6	T187	ochoa	PHD finger protein 6 (PHD-like zinc finger protein)	Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000269\|PubMed:23229552}.
Q8IY57	YAF2	T134	ochoa	YY1-associated factor 2	Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269\|PubMed:11593398, ECO:0000269\|PubMed:12706874, ECO:0000269\|PubMed:9016636}.
Q8IYB3	SRRM1	T435	ochoa	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269\|PubMed:10339552, ECO:0000269\|PubMed:10668804, ECO:0000269\|PubMed:11739730, ECO:0000269\|PubMed:12600940, ECO:0000269\|PubMed:12944400, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q8N6S5	ARL6IP6	T19	ochoa	ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6) (Phosphonoformate immuno-associated protein 1)	None
Q8N8S7	ENAH	T489	ochoa	Protein enabled homolog	Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11696321, ECO:0000269\|PubMed:18158903}.
Q8N8Z6	DCBLD1	T602	ochoa\|psp	Discoidin, CUB and LCCL domain-containing protein 1	None
Q8NC44	RETREG2	T330	ochoa	Reticulophagy regulator 2	Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity). {ECO:0000250\|UniProtKB:Q6NS82, ECO:0000269\|PubMed:34338405}.
Q8NCN4	RNF169	T522	ochoa	E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169)	Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093). Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093). E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269\|PubMed:22492721, ECO:0000269\|PubMed:22733822, ECO:0000269\|PubMed:22742833, ECO:0000269\|PubMed:30104380, ECO:0000269\|PubMed:30773093}.
Q8NEN9	PDZD8	T974	ochoa	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104)	Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). {ECO:0000269\|PubMed:21549406, ECO:0000269\|PubMed:21834987, ECO:0000269\|PubMed:29097544}.
Q8NEY1	NAV1	T1169	ochoa	Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1)	May be involved in neuronal migration. {ECO:0000250}.
Q8NG31	KNL1	T1843	ochoa	Outer kinetochore KNL1 complex subunit KNL1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore scaffold 1) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14)	Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15502821, PubMed:17981135, PubMed:18045986, PubMed:19893618, PubMed:21199919, PubMed:22000412, PubMed:22331848, PubMed:27881301, PubMed:30100357). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (PubMed:18045986, PubMed:19893618, PubMed:27881301). The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:38459127, PubMed:38459128). Required for kinetochore binding by a distinct subset of kMAPs (kinetochore-bound microtubule-associated proteins) and motors (PubMed:19893618). Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (PubMed:18045986, PubMed:27881301). Can bind either to microtubules or to the protein phosphatase 1 (PP1) catalytic subunits PPP1CA and PPP1CC (via overlapping binding sites), it has higher affinity for PP1 (PubMed:30100357). Recruits MAD2L1 to the kinetochore and also directly links BUB1 and BUB1B to the kinetochore (PubMed:17981135, PubMed:19893618, PubMed:22000412, PubMed:22331848, PubMed:25308863). In addition to orienting mitotic chromosomes, it is also essential for alignment of homologous chromosomes during meiotic metaphase I (By similarity). In meiosis I, required to activate the spindle assembly checkpoint at unattached kinetochores to correct erroneous kinetochore-microtubule attachments (By similarity). {ECO:0000250\|UniProtKB:Q66JQ7, ECO:0000269\|PubMed:15502821, ECO:0000269\|PubMed:17981135, ECO:0000269\|PubMed:18045986, ECO:0000269\|PubMed:19893618, ECO:0000269\|PubMed:21199919, ECO:0000269\|PubMed:22000412, ECO:0000269\|PubMed:22331848, ECO:0000269\|PubMed:25308863, ECO:0000269\|PubMed:27881301, ECO:0000269\|PubMed:30100357, ECO:0000269\|PubMed:38459127, ECO:0000269\|PubMed:38459128}.
Q8TBC3	SHKBP1	T630	ochoa	SH3KBP1-binding protein 1 (SETA-binding protein 1)	Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250\|UniProtKB:Q6P7W2}.
Q8TEA8	DTD1	T187	psp	D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related)	Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). {ECO:0000269\|PubMed:15653697, ECO:0000269\|PubMed:20065034}.; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000250\|UniProtKB:Q8IIS0}.
Q8TEJ3	SH3RF3	T383	ochoa	E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)	Has E3 ubiquitin-protein ligase activity. {ECO:0000269\|PubMed:20696164}.
Q8WU79	SMAP2	T206	ochoa	Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like)	GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity). {ECO:0000250}.
Q8WUF5	PPP1R13L	T341	ochoa	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)	Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (PubMed:12524540). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000269\|PubMed:10336463, ECO:0000269\|PubMed:12134007, ECO:0000269\|PubMed:12524540, ECO:0000269\|PubMed:15489900, ECO:0000269\|PubMed:28069640}.
Q8WWI1	LMO7	T259	ochoa	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	None
Q8WWI1	LMO7	T859	ochoa	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	None
Q8WWI1	LMO7	T913	ochoa	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	None
Q8WWI1	LMO7	T1578	ochoa	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	None
Q8WWK9	CKAP2	T597	ochoa\|psp	Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein)	Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.
Q92613	JADE3	T549	ochoa	Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16)	Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. {ECO:0000269\|PubMed:16387653}.
Q92844	TANK	T213	ochoa	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269\|PubMed:12133833, ECO:0000269\|PubMed:21931631, ECO:0000269\|PubMed:25861989}.
Q96A65	EXOC4	T237	ochoa	Exocyst complex component 4 (Exocyst complex component Sec8)	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250\|UniProtKB:Q62824}.
Q96AG3	SLC25A46	T44	ochoa	Mitochondrial outer membrane protein SLC25A46 (Solute carrier family 25 member 46)	Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization (PubMed:26168012, PubMed:27390132, PubMed:27543974). May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane (PubMed:27390132). Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission (PubMed:27390132). {ECO:0000269\|PubMed:26168012, ECO:0000269\|PubMed:27390132, ECO:0000269\|PubMed:27543974}.
Q96AP7	ESAM	T349	ochoa	Endothelial cell-selective adhesion molecule	Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250\|UniProtKB:Q925F2}.
Q96CJ1	EAF2	T137	ochoa	ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein)	Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo. {ECO:0000250, ECO:0000269\|PubMed:12446457, ECO:0000269\|PubMed:12907652, ECO:0000269\|PubMed:16006523}.
Q96D71	REPS1	T520	ochoa	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)	May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. {ECO:0000250}.
Q96G74	OTUD5	T433	ochoa	OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)	Deubiquitinating enzyme that functions as a negative regulator of the innate immune system (PubMed:17991829, PubMed:22245969, PubMed:23827681, PubMed:33523931). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:22245969). Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (PubMed:22245969). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production (PubMed:17991829). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931). Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability (PubMed:33110214). {ECO:0000269\|PubMed:17991829, ECO:0000269\|PubMed:22245969, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:33110214, ECO:0000269\|PubMed:33523931}.
Q96NE9	FRMD6	T394	ochoa	FERM domain-containing protein 6 (Willin)	None
Q96PU5	NEDD4L	T318	ochoa	E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair (PubMed:20064473, PubMed:31959741, PubMed:33608556). Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation (PubMed:15496141). Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels (PubMed:28820317, PubMed:31959741). Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 (PubMed:33608556). Ubiquitinates TTYH2 and TTYH3 and regulates protein levels of TTYH2 (PubMed:18577513). {ECO:0000250\|UniProtKB:Q8CFI0, ECO:0000269\|PubMed:12911626, ECO:0000269\|PubMed:15040001, ECO:0000269\|PubMed:15217910, ECO:0000269\|PubMed:15489223, ECO:0000269\|PubMed:15496141, ECO:0000269\|PubMed:15576372, ECO:0000269\|PubMed:18577513, ECO:0000269\|PubMed:19144635, ECO:0000269\|PubMed:23999003, ECO:0000269\|PubMed:25631046, ECO:0000269\|PubMed:26363003, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:27694961, ECO:0000269\|PubMed:33608556}.
Q96QT4	TRPM7	T1487	ochoa	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]	Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644). {ECO:0000250\|UniProtKB:Q923J1, ECO:0000269\|PubMed:11385574, ECO:0000269\|PubMed:12887921, ECO:0000269\|PubMed:15485879, ECO:0000269\|PubMed:18365021, ECO:0000269\|PubMed:18394644, ECO:0000269\|PubMed:24316671, ECO:0000269\|PubMed:35561741, ECO:0000269\|PubMed:36027648}.; FUNCTION: [TRPM7 channel, cleaved form]: The cleaved channel exhibits substantially higher current and potentiates Fas receptor signaling. {ECO:0000250\|UniProtKB:Q923J1}.; FUNCTION: [TRPM7 kinase, cleaved form]: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. In immune cells, the TRPM7 kinase domain is clipped from the channel domain by caspases in response to Fas-receptor stimulation. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins in a Zn(2+)-dependent manner to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and embryonic development. {ECO:0000250\|UniProtKB:Q923J1}.
Q96RT1	ERBIN	T648	ochoa	Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269\|PubMed:10878805, ECO:0000269\|PubMed:16203728}.
Q96RT1	ERBIN	T1116	ochoa	Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269\|PubMed:10878805, ECO:0000269\|PubMed:16203728}.
Q96S55	WRNIP1	T116	ochoa	ATPase WRNIP1 (EC 3.6.1.-) (Werner helicase-interacting protein 1)	Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. {ECO:0000269\|PubMed:15670210, ECO:0000269\|PubMed:29053956}.
Q96T23	RSF1	T1393	ochoa	Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex)	Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984). {ECO:0000269\|PubMed:11788598, ECO:0000269\|PubMed:11944984, ECO:0000269\|PubMed:12972596, ECO:0000269\|PubMed:28801535}.
Q99569	PKP4	T264	ochoa	Plakophilin-4 (p0071)	Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269\|PubMed:17115030}.
Q99569	PKP4	T440	ochoa	Plakophilin-4 (p0071)	Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269\|PubMed:17115030}.
Q99759	MAP3K3	T294	psp	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)	Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269\|PubMed:12912994, ECO:0000269\|PubMed:14661019, ECO:0000269\|PubMed:14743216, ECO:0000269\|PubMed:33729480, ECO:0000269\|PubMed:33891857, ECO:0000269\|PubMed:9006902}.
Q9BTA9	WAC	T224	ochoa	WW domain-containing adapter protein with coiled-coil	Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269\|PubMed:21329877, ECO:0000269\|PubMed:22354037, ECO:0000269\|PubMed:26812014}.
Q9BTA9	WAC	T244	ochoa\|psp	WW domain-containing adapter protein with coiled-coil	Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877). {ECO:0000269\|PubMed:21329877, ECO:0000269\|PubMed:22354037, ECO:0000269\|PubMed:26812014}.
Q9BV36	MLPH	T249	ochoa	Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)	Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. {ECO:0000269\|PubMed:12062444}.
Q9BWH6	RPAP1	T184	ochoa	RNA polymerase II-associated protein 1	Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3. {ECO:0000269\|PubMed:17643375}.
Q9BXB4	OSBPL11	T27	ochoa	Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)	Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189). {ECO:0000269\|PubMed:17428193, ECO:0000269\|PubMed:23028956, ECO:0000269\|PubMed:39106189}.
Q9BXI6	TBC1D10A	T22	ochoa	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha)	GTPase-activating protein (GAP) specific for RAB27A and RAB35 (PubMed:16923811, PubMed:30905672). Does not show GAP activity for RAB2A, RAB3A and RAB4A (PubMed:16923811). {ECO:0000269\|PubMed:16923811, ECO:0000269\|PubMed:30905672}.
Q9C0D5	TANC1	T1661	ochoa	Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)	May be a scaffold component in the postsynaptic density. {ECO:0000250}.
Q9H0D6	XRN2	T439	ochoa\|psp	5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)	Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269\|PubMed:15565158, ECO:0000269\|PubMed:16648491, ECO:0000269\|PubMed:21700224}.
Q9H0H5	RACGAP1	T342	ochoa	Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)	Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269\|PubMed:10979956, ECO:0000269\|PubMed:11085985, ECO:0000269\|PubMed:11278976, ECO:0000269\|PubMed:11782313, ECO:0000269\|PubMed:14729465, ECO:0000269\|PubMed:15642749, ECO:0000269\|PubMed:16103226, ECO:0000269\|PubMed:16129829, ECO:0000269\|PubMed:16236794, ECO:0000269\|PubMed:18511905, ECO:0000269\|PubMed:19468300, ECO:0000269\|PubMed:19468302, ECO:0000269\|PubMed:23235882, ECO:0000269\|PubMed:9497316}.
Q9H7D0	DOCK5	T1786	ochoa	Dedicator of cytokinesis protein 5	Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250\|UniProtKB:B2RY04, ECO:0000269\|PubMed:19004829}.
Q9H8V3	ECT2	T359	ochoa\|psp	Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)	Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269\|PubMed:10579713, ECO:0000269\|PubMed:14645260, ECO:0000269\|PubMed:15254234, ECO:0000269\|PubMed:15545273, ECO:0000269\|PubMed:15642749, ECO:0000269\|PubMed:16103226, ECO:0000269\|PubMed:16170345, ECO:0000269\|PubMed:16236794, ECO:0000269\|PubMed:16495035, ECO:0000269\|PubMed:19129481, ECO:0000269\|PubMed:19468300, ECO:0000269\|PubMed:19617897, ECO:0000269\|PubMed:21189248, ECO:0000269\|PubMed:21373644, ECO:0000269\|PubMed:25068414, ECO:0000269\|PubMed:31888991}.
Q9HC44	GPBP1L1	T279	ochoa	Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1)	Possible transcription factor. {ECO:0000305}.
Q9NQC7	CYLD	T424	ochoa	Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)	Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). {ECO:0000250\|UniProtKB:Q80TQ2, ECO:0000269\|PubMed:12917689, ECO:0000269\|PubMed:12917690, ECO:0000269\|PubMed:12917691, ECO:0000269\|PubMed:17495026, ECO:0000269\|PubMed:18222923, ECO:0000269\|PubMed:18313383, ECO:0000269\|PubMed:18636086, ECO:0000269\|PubMed:19893491, ECO:0000269\|PubMed:20194890, ECO:0000269\|PubMed:20227366, ECO:0000269\|PubMed:26670046, ECO:0000269\|PubMed:26997266, ECO:0000269\|PubMed:27458237, ECO:0000269\|PubMed:27591049, ECO:0000269\|PubMed:27746020, ECO:0000269\|PubMed:29291351, ECO:0000269\|PubMed:32185393, ECO:0000269\|PubMed:34497368}.
Q9NQS7	INCENP	T294	ochoa	Inner centromere protein	Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428). {ECO:0000250\|UniProtKB:P53352, ECO:0000269\|PubMed:12925766, ECO:0000269\|PubMed:15316025, ECO:0000269\|PubMed:16760428, ECO:0000269\|PubMed:21346195, ECO:0000269\|PubMed:27332895}.
Q9NQW6	ANLN	T327	ochoa	Anillin	Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269\|PubMed:10931866, ECO:0000269\|PubMed:12479805, ECO:0000269\|PubMed:15496454, ECO:0000269\|PubMed:16040610, ECO:0000269\|PubMed:16357138, ECO:0000269\|PubMed:23870127, ECO:0000269\|PubMed:24676636}.
Q9NQW6	ANLN	T341	ochoa	Anillin	Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269\|PubMed:10931866, ECO:0000269\|PubMed:12479805, ECO:0000269\|PubMed:15496454, ECO:0000269\|PubMed:16040610, ECO:0000269\|PubMed:16357138, ECO:0000269\|PubMed:23870127, ECO:0000269\|PubMed:24676636}.
Q9NQW6	ANLN	T401	ochoa	Anillin	Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). {ECO:0000269\|PubMed:10931866, ECO:0000269\|PubMed:12479805, ECO:0000269\|PubMed:15496454, ECO:0000269\|PubMed:16040610, ECO:0000269\|PubMed:16357138, ECO:0000269\|PubMed:23870127, ECO:0000269\|PubMed:24676636}.
Q9NQX3	GPHN	T266	ochoa	Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]	Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250\|UniProtKB:Q03555, ECO:0000269\|PubMed:25025157, ECO:0000269\|PubMed:26613940}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269\|PubMed:26613940}.
Q9NRR3	CDC42SE2	T38	ochoa	CDC42 small effector protein 2 (Small effector of CDC42 protein 2)	Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. {ECO:0000269\|PubMed:10816584, ECO:0000269\|PubMed:15840583}.
Q9NS68	TNFRSF19	T244	ochoa	Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)	Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
Q9NSY1	BMP2K	T1014	ochoa	BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)	May be involved in osteoblast differentiation. {ECO:0000250\|UniProtKB:Q91Z96}.
Q9NTZ6	RBM12	T407	ochoa	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN)	None
Q9NW97	TMEM51	T165	ochoa	Transmembrane protein 51	None
Q9NXH8	TOR4A	T89	ochoa	Torsin-4A (Torsin family 4 member A)	None
Q9NYF8	BCLAF1	T208	ochoa	Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1)	Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269\|PubMed:18794151}.
Q9NYV6	RRN3	T623	ochoa	RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA)	Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269\|PubMed:10758157, ECO:0000269\|PubMed:11250903, ECO:0000269\|PubMed:11265758, ECO:0000269\|PubMed:15805466}.
Q9NZJ0	DTL	T424	ochoa	Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)	Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269\|PubMed:16861906, ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240, ECO:0000269\|PubMed:17085480, ECO:0000269\|PubMed:18703516, ECO:0000269\|PubMed:18794347, ECO:0000269\|PubMed:18794348, ECO:0000269\|PubMed:19332548, ECO:0000269\|PubMed:20129063, ECO:0000269\|PubMed:23478441, ECO:0000269\|PubMed:23478445, ECO:0000269\|PubMed:23677613, ECO:0000269\|PubMed:26431207, ECO:0000269\|PubMed:27906959}.
Q9NZJ0	DTL	T429	ochoa	Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)	Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). {ECO:0000269\|PubMed:16861906, ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240, ECO:0000269\|PubMed:17085480, ECO:0000269\|PubMed:18703516, ECO:0000269\|PubMed:18794347, ECO:0000269\|PubMed:18794348, ECO:0000269\|PubMed:19332548, ECO:0000269\|PubMed:20129063, ECO:0000269\|PubMed:23478441, ECO:0000269\|PubMed:23478445, ECO:0000269\|PubMed:23677613, ECO:0000269\|PubMed:26431207, ECO:0000269\|PubMed:27906959}.
Q9NZN8	CNOT2	T155	ochoa	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2)	Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269\|PubMed:14707134, ECO:0000269\|PubMed:16712523, ECO:0000269\|PubMed:21299754, ECO:0000269\|PubMed:22367759}.
Q9P0K7	RAI14	T283	ochoa	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)	Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier. {ECO:0000250\|UniProtKB:Q5U312}.
Q9P242	NYAP2	T447	ochoa	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2	Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250}.
Q9P2B4	CTTNBP2NL	T551	ochoa	CTTNBP2 N-terminal-like protein	Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). {ECO:0000250\|UniProtKB:Q8SX68, ECO:0000269\|PubMed:18782753}.
Q9UBW5	BIN2	T366	ochoa	Bridging integrator 2 (Breast cancer-associated protein 1)	Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269\|PubMed:23285027}.
Q9UER7	DAXX	T665	ochoa	Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)	Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915). {ECO:0000269\|PubMed:12140263, ECO:0000269\|PubMed:14990586, ECO:0000269\|PubMed:15016915, ECO:0000269\|PubMed:15364927, ECO:0000269\|PubMed:16845383, ECO:0000269\|PubMed:17081986, ECO:0000269\|PubMed:17942542, ECO:0000269\|PubMed:20504901, ECO:0000269\|PubMed:20651253, ECO:0000269\|PubMed:23222847, ECO:0000269\|PubMed:24200965, ECO:0000269\|PubMed:24530302}.
Q9UGV2	NDRG3	T329	ochoa	Protein NDRG3 (N-myc downstream-regulated gene 3 protein)	None
Q9UJ14	GGT7	T56	ochoa	Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain]	Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. {ECO:0000250\|UniProtKB:P19440}.
Q9UJF2	RASAL2	T617	ochoa	Ras GTPase-activating protein nGAP (RAS protein activator-like 2)	Inhibitory regulator of the Ras-cyclic AMP pathway.
Q9UKE5	TNIK	T942	ochoa	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269\|PubMed:10521462, ECO:0000269\|PubMed:15342639, ECO:0000269\|PubMed:19061864, ECO:0000269\|PubMed:19816403, ECO:0000269\|PubMed:20159449, ECO:0000269\|PubMed:21690388, ECO:0000269\|PubMed:26437443}.
Q9ULD2	MTUS1	T1247	ochoa	Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1)	Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269\|PubMed:12692079, ECO:0000269\|PubMed:19794912}.
Q9ULF5	SLC39A10	T553	ochoa	Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)	Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). {ECO:0000250\|UniProtKB:Q6P5F6, ECO:0000269\|PubMed:17359283, ECO:0000269\|PubMed:23186163, ECO:0000269\|PubMed:27274087, ECO:0000269\|PubMed:30520657, ECO:0000269\|PubMed:32797246}.
Q9ULV3	CIZ1	T567	ochoa	Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)	May regulate the subcellular localization of CIP/WAF1.
Q9UPN3	MACF1	T7213	ochoa\|psp	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)	[Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250\|UniProtKB:Q9QXZ0, ECO:0000269\|PubMed:15265687, ECO:0000269\|PubMed:20937854, ECO:0000269\|PubMed:27693509}.
Q9UPN3	MACF1	T7273	ochoa	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)	[Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250\|UniProtKB:Q9QXZ0, ECO:0000269\|PubMed:15265687, ECO:0000269\|PubMed:20937854, ECO:0000269\|PubMed:27693509}.
Q9UPQ0	LIMCH1	T664	ochoa	LIM and calponin homology domains-containing protein 1	Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269\|PubMed:28228547}.
Q9UQ35	SRRM2	T866	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	T885	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	T2104	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9UQ35	SRRM2	T2409	ochoa	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269\|PubMed:19854871, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:9531537, ECO:0000305\|PubMed:33509932}.
Q9Y4B5	MTCL1	T191	ochoa	Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)	Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225). {ECO:0000269\|PubMed:23902687, ECO:0000269\|PubMed:33587225}.
Q9Y4E8	USP15	T219	psp	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)	Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24852371). Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:33093067). May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy (PubMed:24852371). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (PubMed:16005295, PubMed:17318178, PubMed:19576224, PubMed:19826004). Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery (PubMed:27368102). Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9 (PubMed:33093067). {ECO:0000269\|PubMed:16005295, ECO:0000269\|PubMed:17318178, ECO:0000269\|PubMed:19576224, ECO:0000269\|PubMed:19826004, ECO:0000269\|PubMed:21947082, ECO:0000269\|PubMed:22344298, ECO:0000269\|PubMed:24526689, ECO:0000269\|PubMed:24852371, ECO:0000269\|PubMed:27368102, ECO:0000269\|PubMed:33093067}.; FUNCTION: (Microbial infection) Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {ECO:0000269\|PubMed:19553310}.
Q9Y4F5	CEP170B	T870	ochoa	Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B)	Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.
Q9Y4H2	IRS2	T575	ochoa	Insulin receptor substrate 2 (IRS-2)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:15316008, ECO:0000269\|PubMed:19109239, ECO:0000269\|PubMed:24616100, ECO:0000269\|PubMed:25879670, ECO:0000269\|PubMed:32554797}.
Q9Y4H2	IRS2	T1159	ochoa	Insulin receptor substrate 2 (IRS-2)	Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism (PubMed:24616100). Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:15316008, PubMed:19109239). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (By similarity). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (PubMed:24616100). Plays a role in cell cycle progression by promoting a robust spindle assembly checkpoint (SAC) during M-phase (PubMed:32554797). In macrophages, IL4-induced tyrosine phosphorylation of IRS2 leads to the recruitment and activation of phosphoinositide 3-kinase (PI3K) (PubMed:19109239). {ECO:0000250\|UniProtKB:P35570, ECO:0000269\|PubMed:15316008, ECO:0000269\|PubMed:19109239, ECO:0000269\|PubMed:24616100, ECO:0000269\|PubMed:25879670, ECO:0000269\|PubMed:32554797}.
Q9Y608	LRRFIP2	T316	ochoa	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)	May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269\|PubMed:15677333, ECO:0000269\|PubMed:19265123}.
Q9Y6A5	TACC3	T59	ochoa	Transforming acidic coiled-coil-containing protein 3 (ERIC-1)	Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250\|UniProtKB:Q9JJ11, ECO:0000269\|PubMed:14767476, ECO:0000269\|PubMed:21297582, ECO:0000269\|PubMed:23532825}.
R4GMW8	BIVM-ERCC5	T792	ochoa	DNA excision repair protein ERCC-5	None
Q12906	ILF3	T300	Sugiyama	Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)	RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651, PubMed:34110282). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). {ECO:0000269\|PubMed:14731398, ECO:0000269\|PubMed:21123651, ECO:0000269\|PubMed:28625552, ECO:0000269\|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269\|PubMed:26891316}.
O60664	PLIN3	T170	Sugiyama	Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17)	Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269\|PubMed:34077757, ECO:0000269\|PubMed:9590177}.
P31939	ATIC	T297	Sugiyama	Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]	Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269\|PubMed:10985775, ECO:0000269\|PubMed:11948179, ECO:0000269\|PubMed:14756554, ECO:0000269\|PubMed:25687571, ECO:0000269\|PubMed:9378707}.
Q13428	TCOF1	T102	Sugiyama	Treacle protein (Treacher Collins syndrome protein)	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269\|PubMed:12777385, ECO:0000269\|PubMed:26399832}.
Q14247	CTTN	T328	Sugiyama	Src substrate cortactin (Amplaxin) (Oncogene EMS1)	Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). {ECO:0000250\|UniProtKB:Q60598, ECO:0000250\|UniProtKB:Q66HL2, ECO:0000269\|PubMed:16636290, ECO:0000269\|PubMed:17959782, ECO:0000269\|PubMed:21296879, ECO:0000269\|PubMed:23144454}.
Q5H9R7	PPP6R3	T507	Sugiyama	Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)	Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. {ECO:0000269\|PubMed:11401438, ECO:0000269\|PubMed:16769727}.
P08151	GLI1	T527	GPS6	Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)	Acts as a transcriptional activator (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407). {ECO:0000269\|PubMed:10806483, ECO:0000269\|PubMed:11238441, ECO:0000269\|PubMed:19706761, ECO:0000269\|PubMed:19878745, ECO:0000269\|PubMed:2105456, ECO:0000269\|PubMed:24076122, ECO:0000269\|PubMed:24217340, ECO:0000269\|PubMed:24311597, ECO:0000269\|PubMed:28973407, ECO:0000269\|PubMed:8378770}.; FUNCTION: [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {ECO:0000269\|PubMed:19706761}.
Q9BZL6	PRKD2	T227	Sugiyama	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:14743217, PubMed:15604256, PubMed:16928771, PubMed:17077180, PubMed:17951978, PubMed:17962809, PubMed:18262756, PubMed:19001381, PubMed:19192391, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B (PubMed:15604256, PubMed:28428613). In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 (PubMed:17962809). Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation (PubMed:17077180). During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway (PubMed:16928771). During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors (PubMed:19192391). In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane (PubMed:14743217). Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis (PubMed:19001381). In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN (PubMed:18262756). Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells (PubMed:17951978). Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion (PubMed:23503467). {ECO:0000250\|UniProtKB:Q8BZ03, ECO:0000269\|PubMed:14743217, ECO:0000269\|PubMed:15604256, ECO:0000269\|PubMed:16928771, ECO:0000269\|PubMed:17077180, ECO:0000269\|PubMed:17951978, ECO:0000269\|PubMed:17962809, ECO:0000269\|PubMed:18262756, ECO:0000269\|PubMed:19001381, ECO:0000269\|PubMed:19192391, ECO:0000269\|PubMed:23503467, ECO:0000269\|PubMed:28428613}.
P50402	EMD	T43	Sugiyama	Emerin	Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. {ECO:0000269\|PubMed:15328537, ECO:0000269\|PubMed:16680152, ECO:0000269\|PubMed:16858403, ECO:0000269\|PubMed:17785515, ECO:0000269\|PubMed:19323649, ECO:0000269\|PubMed:32923640}.

Download

reactome_id	name	p	-log10_p
R-HSA-2980766	Nuclear Envelope Breakdown	0.000006	5.194
R-HSA-68875	Mitotic Prophase	0.000034	4.468
R-HSA-69618	Mitotic Spindle Checkpoint	0.000262	3.582
R-HSA-68882	Mitotic Anaphase	0.000216	3.665
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.000225	3.648
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.000267	3.573
R-HSA-416482	G alpha (12/13) signalling events	0.000309	3.511
R-HSA-68886	M Phase	0.000333	3.478
R-HSA-4419969	Depolymerization of the Nuclear Lamina	0.000396	3.402
R-HSA-141424	Amplification of signal from the kinetochores	0.000522	3.283
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory si...	0.000522	3.283
R-HSA-1640170	Cell Cycle	0.000483	3.316
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.000632	3.199
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.000695	3.158
R-HSA-2995383	Initiation of Nuclear Envelope (NE) Reformation	0.000719	3.143
R-HSA-69278	Cell Cycle, Mitotic	0.001119	2.951
R-HSA-75153	Apoptotic execution phase	0.001283	2.892
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC...	0.002054	2.687
R-HSA-1855196	IP3 and IP4 transport between cytosol and nucleus	0.002266	2.645
R-HSA-1855229	IP6 and IP7 transport between cytosol and nucleus	0.002266	2.645
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.002256	2.647
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	0.002200	2.658
R-HSA-9008059	Interleukin-37 signaling	0.002054	2.687
R-HSA-1855170	IPs transport between nucleus and cytosol	0.002734	2.563
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.002734	2.563
R-HSA-193648	NRAGE signals death through JNK	0.002669	2.574
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.002992	2.524
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.002992	2.524
R-HSA-180746	Nuclear import of Rev protein	0.003265	2.486
R-HSA-162582	Signal Transduction	0.003172	2.499
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.003556	2.449
R-HSA-73886	Chromosome Maintenance	0.003995	2.398
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.003995	2.398
R-HSA-6784531	tRNA processing in the nucleus	0.003896	2.409
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.004187	2.378
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.004530	2.344
R-HSA-74713	IRS activation	0.004858	2.314
R-HSA-9673768	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB	0.004858	2.314
R-HSA-447038	NrCAM interactions	0.004858	2.314
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.004891	2.311
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.004908	2.309
R-HSA-177243	Interactions of Rev with host cellular proteins	0.005271	2.278
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.005271	2.278
R-HSA-3214847	HATs acetylate histones	0.005928	2.227
R-HSA-2467813	Separation of Sister Chromatids	0.005713	2.243
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.005670	2.246
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers	0.005851	2.233
R-HSA-5635851	GLI proteins bind promoters of Hh responsive genes to promote transcription	0.006284	2.202
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen...	0.006284	2.202
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.007113	2.148
R-HSA-5578749	Transcriptional regulation by small RNAs	0.006762	2.170
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.007113	2.148
R-HSA-8951671	RUNX3 regulates YAP1-mediated transcription	0.007878	2.104
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.007969	2.099
R-HSA-69620	Cell Cycle Checkpoints	0.008314	2.080
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.008492	2.071
R-HSA-112412	SOS-mediated signalling	0.009634	2.016
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.009604	2.018
R-HSA-2995410	Nuclear Envelope (NE) Reassembly	0.009928	2.003
R-HSA-9828211	Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	0.011546	1.938
R-HSA-390696	Adrenoceptors	0.011546	1.938
R-HSA-373760	L1CAM interactions	0.012748	1.895
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.013611	1.866
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.013945	1.856
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.014488	1.839
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	0.015823	1.801
R-HSA-198203	PI3K/AKT activation	0.015823	1.801
R-HSA-74749	Signal attenuation	0.015823	1.801
R-HSA-2586552	Signaling by Leptin	0.015823	1.801
R-HSA-451306	Ionotropic activity of kainate receptors	0.018177	1.740
R-HSA-194441	Metabolism of non-coding RNA	0.017409	1.759
R-HSA-191859	snRNP Assembly	0.017409	1.759
R-HSA-168325	Viral Messenger RNA Synthesis	0.019152	1.718
R-HSA-1227986	Signaling by ERBB2	0.018267	1.738
R-HSA-109581	Apoptosis	0.017419	1.759
R-HSA-199991	Membrane Trafficking	0.019846	1.702
R-HSA-9824878	Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7	0.020670	1.685
R-HSA-9931512	Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters	0.020670	1.685
R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	0.020670	1.685
R-HSA-9027276	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	0.023296	1.633
R-HSA-69091	Polymerase switching	0.023296	1.633
R-HSA-69109	Leading Strand Synthesis	0.023296	1.633
R-HSA-157579	Telomere Maintenance	0.021956	1.658
R-HSA-193704	p75 NTR receptor-mediated signalling	0.023520	1.629
R-HSA-70171	Glycolysis	0.024329	1.614
R-HSA-9670621	Defective Inhibition of DNA Recombination at Telomere	0.028767	1.541
R-HSA-9006821	Alternative Lengthening of Telomeres (ALT)	0.028767	1.541
R-HSA-9673013	Diseases of Telomere Maintenance	0.028767	1.541
R-HSA-5602566	TICAM1 deficiency - HSE	0.028767	1.541
R-HSA-9670613	Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	0.028767	1.541
R-HSA-9670615	Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	0.028767	1.541
R-HSA-9925563	Developmental Lineage of Pancreatic Ductal Cells	0.027183	1.566
R-HSA-111452	Activation and oligomerization of BAK protein	0.028767	1.541
R-HSA-114294	Activation, translocation and oligomerization of BAX	0.028767	1.541
R-HSA-77042	Formation of editosomes by ADAR proteins	0.028767	1.541
R-HSA-8853659	RET signaling	0.025728	1.590
R-HSA-69166	Removal of the Flap Intermediate	0.028932	1.539
R-HSA-9931509	Expression of BMAL (ARNTL), CLOCK, and NPAS2	0.030525	1.515
R-HSA-211000	Gene Silencing by RNA	0.031442	1.502
R-HSA-69183	Processive synthesis on the lagging strand	0.031933	1.496
R-HSA-446353	Cell-extracellular matrix interactions	0.031933	1.496
R-HSA-8856828	Clathrin-mediated endocytosis	0.031963	1.495
R-HSA-9931521	The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL...	0.038282	1.417
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.038282	1.417
R-HSA-936964	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	0.038282	1.417
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anapha...	0.038282	1.417
R-HSA-3247509	Chromatin modifying enzymes	0.034336	1.464
R-HSA-68877	Mitotic Prometaphase	0.037403	1.427
R-HSA-1169408	ISG15 antiviral mechanism	0.034347	1.464
R-HSA-9609690	HCMV Early Events	0.039827	1.400
R-HSA-5602571	TRAF3 deficiency - HSE	0.042840	1.368
R-HSA-5619111	Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	0.042840	1.368
R-HSA-9665230	Drug resistance in ERBB2 KD mutants	0.056710	1.246
R-HSA-75108	Activation, myristolyation of BID and translocation to mitochondria	0.056710	1.246
R-HSA-9652282	Drug-mediated inhibition of ERBB2 signaling	0.056710	1.246
R-HSA-8951911	RUNX3 regulates RUNX1-mediated transcription	0.056710	1.246
R-HSA-9665250	Resistance of ERBB2 KD mutants to AEE788	0.056710	1.246
R-HSA-9665249	Resistance of ERBB2 KD mutants to afatinib	0.056710	1.246
R-HSA-9665247	Resistance of ERBB2 KD mutants to osimertinib	0.056710	1.246
R-HSA-9665244	Resistance of ERBB2 KD mutants to sapitinib	0.056710	1.246
R-HSA-9665245	Resistance of ERBB2 KD mutants to tesevatinib	0.056710	1.246
R-HSA-9665233	Resistance of ERBB2 KD mutants to trastuzumab	0.056710	1.246
R-HSA-9665251	Resistance of ERBB2 KD mutants to lapatinib	0.056710	1.246
R-HSA-9665246	Resistance of ERBB2 KD mutants to neratinib	0.056710	1.246
R-HSA-9665737	Drug resistance in ERBB2 TMD/JMD mutants	0.056710	1.246
R-HSA-180292	GAB1 signalosome	0.045066	1.346
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.055993	1.252
R-HSA-438066	Unblocking of NMDA receptors, glutamate binding and activation	0.059822	1.223
R-HSA-442982	Ras activation upon Ca2+ influx through NMDA receptor	0.059822	1.223
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	0.043403	1.362
R-HSA-774815	Nucleosome assembly	0.043403	1.362
R-HSA-73772	RNA Polymerase I Promoter Escape	0.058566	1.232
R-HSA-69186	Lagging Strand Synthesis	0.055993	1.252
R-HSA-75064	mRNA Editing: A to I Conversion	0.056710	1.246
R-HSA-75102	C6 deamination of adenosine	0.056710	1.246
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.056710	1.246
R-HSA-9665348	Signaling by ERBB2 ECD mutants	0.045066	1.346
R-HSA-9610379	HCMV Late Events	0.044777	1.349
R-HSA-4839726	Chromatin organization	0.045379	1.343
R-HSA-352238	Breakdown of the nuclear lamina	0.042840	1.368
R-HSA-2028269	Signaling by Hippo	0.041621	1.381
R-HSA-9617324	Negative regulation of NMDA receptor-mediated neuronal transmission	0.059822	1.223
R-HSA-73887	Death Receptor Signaling	0.041798	1.379
R-HSA-109704	PI3K Cascade	0.054008	1.268
R-HSA-162909	Host Interactions of HIV factors	0.053135	1.275
R-HSA-9645723	Diseases of programmed cell death	0.054948	1.260
R-HSA-8849932	Synaptic adhesion-like molecules	0.045066	1.346
R-HSA-70326	Glucose metabolism	0.044341	1.353
R-HSA-9926550	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adh...	0.045066	1.346
R-HSA-9617828	FOXO-mediated transcription of cell cycle genes	0.059822	1.223
R-HSA-5357801	Programmed Cell Death	0.048640	1.313
R-HSA-9671555	Signaling by PDGFR in disease	0.059822	1.223
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	0.060911	1.215
R-HSA-166208	mTORC1-mediated signalling	0.063738	1.196
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	0.063738	1.196
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.070380	1.153
R-HSA-8865999	MET activates PTPN11	0.070380	1.153
R-HSA-9013957	TLR3-mediated TICAM1-dependent programmed cell death	0.083852	1.076
R-HSA-8952158	RUNX3 regulates BCL2L11 (BIM) transcription	0.083852	1.076
R-HSA-1306955	GRB7 events in ERBB2 signaling	0.083852	1.076
R-HSA-8941855	RUNX3 regulates CDKN1A transcription	0.110217	0.958
R-HSA-9842640	Signaling by LTK in cancer	0.123114	0.910
R-HSA-9027283	Erythropoietin activates STAT5	0.123114	0.910
R-HSA-8949275	RUNX3 Regulates Immune Response and Cell Migration	0.135826	0.867
R-HSA-8851907	MET activates PI3K/AKT signaling	0.135826	0.867
R-HSA-2562578	TRIF-mediated programmed cell death	0.135826	0.867
R-HSA-446107	Type I hemidesmosome assembly	0.148354	0.829
R-HSA-9028335	Activated NTRK2 signals through PI3K	0.148354	0.829
R-HSA-196025	Formation of annular gap junctions	0.148354	0.829
R-HSA-8875656	MET receptor recycling	0.148354	0.829
R-HSA-9613354	Lipophagy	0.160701	0.794
R-HSA-190873	Gap junction degradation	0.160701	0.794
R-HSA-201688	WNT mediated activation of DVL	0.160701	0.794
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	0.172870	0.762
R-HSA-8875555	MET activates RAP1 and RAC1	0.172870	0.762
R-HSA-9027277	Erythropoietin activates Phospholipase C gamma (PLCG)	0.172870	0.762
R-HSA-68952	DNA replication initiation	0.172870	0.762
R-HSA-4839744	Signaling by APC mutants	0.184863	0.733
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.184863	0.733
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.184863	0.733
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.184863	0.733
R-HSA-429947	Deadenylation of mRNA	0.071819	1.144
R-HSA-5339716	Signaling by GSK3beta mutants	0.196683	0.706
R-HSA-9931510	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene...	0.080210	1.096
R-HSA-8951936	RUNX3 regulates p14-ARF	0.208332	0.681
R-HSA-4839743	Signaling by CTNNB1 phospho-site mutants	0.208332	0.681
R-HSA-9820865	Z-decay: degradation of maternal mRNAs by zygotically expressed factors	0.208332	0.681
R-HSA-5358749	CTNNB1 S37 mutants aren't phosphorylated	0.208332	0.681
R-HSA-5358751	CTNNB1 S45 mutants aren't phosphorylated	0.208332	0.681
R-HSA-5358752	CTNNB1 T41 mutants aren't phosphorylated	0.208332	0.681
R-HSA-5358747	CTNNB1 S33 mutants aren't phosphorylated	0.208332	0.681
R-HSA-445095	Interaction between L1 and Ankyrins	0.084514	1.073
R-HSA-9006335	Signaling by Erythropoietin	0.093325	1.030
R-HSA-9027284	Erythropoietin activates RAS	0.242280	0.616
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	0.242280	0.616
R-HSA-196299	Beta-catenin phosphorylation cascade	0.242280	0.616
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	0.242280	0.616
R-HSA-1362300	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL...	0.253271	0.596
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.253271	0.596
R-HSA-176412	Phosphorylation of the APC/C	0.253271	0.596
R-HSA-9687136	Aberrant regulation of mitotic exit in cancer due to RB1 defects	0.253271	0.596
R-HSA-5696400	Dual Incision in GG-NER	0.121185	0.917
R-HSA-9927426	Developmental Lineage of Mammary Gland Alveolar Cells	0.121185	0.917
R-HSA-8964616	G beta:gamma signalling through CDC42	0.264103	0.578
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.264103	0.578
R-HSA-9670095	Inhibition of DNA recombination at telomere	0.150759	0.822
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	0.092286	1.035
R-HSA-5610780	Degradation of GLI1 by the proteasome	0.160913	0.793
R-HSA-9927418	Developmental Lineage of Mammary Gland Luminal Epithelial Cells	0.166036	0.780
R-HSA-2299718	Condensation of Prophase Chromosomes	0.186791	0.729
R-HSA-72187	mRNA 3'-end processing	0.218522	0.661
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	0.218522	0.661
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of th...	0.223859	0.650
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	0.234563	0.630
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.239926	0.620
R-HSA-9845323	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	0.261425	0.583
R-HSA-72163	mRNA Splicing - Major Pathway	0.093879	1.027
R-HSA-72172	mRNA Splicing	0.111980	0.951
R-HSA-5099900	WNT5A-dependent internalization of FZD4	0.253271	0.596
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.130878	0.883
R-HSA-9931529	Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK	0.097130	1.013
R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression	0.148354	0.829
R-HSA-9796292	Formation of axial mesoderm	0.219813	0.658
R-HSA-174430	Telomere C-strand synthesis initiation	0.242280	0.616
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at...	0.256046	0.592
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.160913	0.793
R-HSA-8941856	RUNX3 regulates NOTCH signaling	0.208332	0.681
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.084514	1.073
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	0.110023	0.959
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.223859	0.650
R-HSA-6782135	Dual incision in TC-NER	0.250669	0.601
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	0.148354	0.829
R-HSA-69190	DNA strand elongation	0.107008	0.971
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	0.253271	0.596
R-HSA-9664420	Killing mechanisms	0.253271	0.596
R-HSA-9710421	Defective pyroptosis	0.171187	0.767
R-HSA-1221632	Meiotic synapsis	0.223859	0.650
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub...	0.250669	0.601
R-HSA-73864	RNA Polymerase I Transcription	0.132214	0.879
R-HSA-74158	RNA Polymerase III Transcription	0.130878	0.883
R-HSA-9909396	Circadian clock	0.172056	0.764
R-HSA-9609646	HCMV Infection	0.102778	0.988
R-HSA-8951430	RUNX3 regulates WNT signaling	0.135826	0.867
R-HSA-9933937	Formation of the canonical BAF (cBAF) complex	0.231128	0.636
R-HSA-9675126	Diseases of mitotic cell cycle	0.107008	0.971
R-HSA-9933946	Formation of the embryonic stem cell BAF (esBAF) complex	0.242280	0.616
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.125721	0.901
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	0.152365	0.817
R-HSA-2428928	IRS-related events triggered by IGF1R	0.081190	1.090
R-HSA-6794361	Neurexins and neuroligins	0.218522	0.661
R-HSA-9820841	M-decay: degradation of maternal mRNAs by maternally stored factors	0.155820	0.807
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.231128	0.636
R-HSA-6802957	Oncogenic MAPK signaling	0.155814	0.807
R-HSA-180786	Extension of Telomeres	0.075874	1.120
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	0.071819	1.144
R-HSA-202670	ERKs are inactivated	0.196683	0.706
R-HSA-4839748	Signaling by AMER1 mutants	0.196683	0.706
R-HSA-4839735	Signaling by AXIN mutants	0.196683	0.706
R-HSA-9634285	Constitutive Signaling by Overexpressed ERBB2	0.208332	0.681
R-HSA-1227990	Signaling by ERBB2 in Cancer	0.097827	1.010
R-HSA-429914	Deadenylation-dependent mRNA decay	0.075874	1.120
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.166036	0.780
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.067273	1.172
R-HSA-9734779	Developmental Cell Lineages of the Integumentary System	0.100274	0.999
R-HSA-73856	RNA Polymerase II Transcription Termination	0.266805	0.574
R-HSA-69239	Synthesis of DNA	0.252216	0.598
R-HSA-112399	IRS-mediated signalling	0.070720	1.150
R-HSA-9909649	Regulation of PD-L1(CD274) transcription	0.095153	1.022
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	0.155373	0.809
R-HSA-9620244	Long-term potentiation	0.075977	1.119
R-HSA-9664565	Signaling by ERBB2 KD Mutants	0.093325	1.030
R-HSA-2428924	IGF1R signaling cascade	0.089455	1.048
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.097673	1.010
R-HSA-5632684	Hedgehog 'on' state	0.110023	0.959
R-HSA-9603381	Activated NTRK3 signals through PI3K	0.135826	0.867
R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.148354	0.829
R-HSA-450341	Activation of the AP-1 family of transcription factors	0.160701	0.794
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno...	0.111682	0.952
R-HSA-74751	Insulin receptor signalling cascade	0.089455	1.048
R-HSA-5693532	DNA Double-Strand Break Repair	0.107148	0.970
R-HSA-166166	MyD88-independent TLR4 cascade	0.104845	0.979
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.093596	1.029
R-HSA-6809371	Formation of the cornified envelope	0.144622	0.840
R-HSA-9816359	Maternal to zygotic transition (MZT)	0.141979	0.848
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.092286	1.035
R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	0.104845	0.979
R-HSA-6794362	Protein-protein interactions at synapses	0.155814	0.807
R-HSA-9734767	Developmental Cell Lineages	0.122808	0.911
R-HSA-5260271	Diseases of Immune System	0.150759	0.822
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.150759	0.822
R-HSA-5610787	Hedgehog 'off' state	0.221450	0.655
R-HSA-168898	Toll-like Receptor Cascades	0.194655	0.711
R-HSA-75072	mRNA Editing	0.160701	0.794
R-HSA-9706019	RHOBTB3 ATPase cycle	0.184863	0.733
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.196683	0.706
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.075977	1.119
R-HSA-451326	Activation of kainate receptors upon glutamate binding	0.088887	1.051
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.264103	0.578
R-HSA-445355	Smooth Muscle Contraction	0.223859	0.650
R-HSA-9609736	Assembly and cell surface presentation of NMDA receptors	0.160913	0.793
R-HSA-9842663	Signaling by LTK	0.208332	0.681
R-HSA-74752	Signaling by Insulin receptor	0.187875	0.726
R-HSA-9762293	Regulation of CDH11 gene transcription	0.160701	0.794
R-HSA-8863795	Downregulation of ERBB2 signaling	0.097827	1.010
R-HSA-442742	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	0.111682	0.952
R-HSA-442755	Activation of NMDA receptors and postsynaptic events	0.229072	0.640
R-HSA-3214841	PKMTs methylate histone lysines	0.155820	0.807
R-HSA-3214858	RMTs methylate histone arginines	0.176365	0.754
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.089266	1.049
R-HSA-69242	S Phase	0.225367	0.647
R-HSA-427652	Sodium-coupled phosphate cotransporters	0.110217	0.958
R-HSA-428890	Role of ABL in ROBO-SLIT signaling	0.135826	0.867
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.135826	0.867
R-HSA-425986	Sodium/Proton exchangers	0.148354	0.829
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.242280	0.616
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.242280	0.616
R-HSA-9725554	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	0.145732	0.836
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	0.192037	0.717
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	0.218522	0.661
R-HSA-8953854	Metabolism of RNA	0.187725	0.726
R-HSA-69306	DNA Replication	0.240883	0.618
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.250669	0.601
R-HSA-177929	Signaling by EGFR	0.239926	0.620
R-HSA-9824585	Regulation of MITF-M-dependent genes involved in pigmentation	0.181567	0.741
R-HSA-5653656	Vesicle-mediated transport	0.100917	0.996
R-HSA-5655291	Signaling by FGFR4 in disease	0.231128	0.636
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	0.231128	0.636
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.242280	0.616
R-HSA-111447	Activation of BAD and translocation to mitochondria	0.242280	0.616
R-HSA-9820448	Developmental Cell Lineages of the Exocrine Pancreas	0.237759	0.624
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	0.093325	1.030
R-HSA-9945266	Differentiation of T cells	0.253271	0.596
R-HSA-9942503	Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	0.253271	0.596
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.264103	0.578
R-HSA-438064	Post NMDA receptor activation events	0.166305	0.779
R-HSA-2559580	Oxidative Stress Induced Senescence	0.229072	0.640
R-HSA-442380	Zinc influx into cells by the SLC39 gene family	0.160701	0.794
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	0.242280	0.616
R-HSA-9707616	Heme signaling	0.083906	1.076
R-HSA-5673001	RAF/MAP kinase cascade	0.085364	1.069
R-HSA-9725370	Signaling by ALK fusions and activated point mutants	0.098024	1.009
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	0.102389	0.990
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	0.198920	0.701
R-HSA-73893	DNA Damage Bypass	0.202585	0.693
R-HSA-5684996	MAPK1/MAPK3 signaling	0.093986	1.027
R-HSA-9764790	Positive Regulation of CDH1 Gene Transcription	0.172870	0.762
R-HSA-5689896	Ovarian tumor domain proteases	0.135789	0.867
R-HSA-437239	Recycling pathway of L1	0.192037	0.717
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.141979	0.848
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.247158	0.607
R-HSA-9700206	Signaling by ALK in cancer	0.098024	1.009
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's dis...	0.071819	1.144
R-HSA-8863678	Neurodegenerative Diseases	0.071819	1.144
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.171187	0.767
R-HSA-1483249	Inositol phosphate metabolism	0.109510	0.961
R-HSA-9734009	Defective Intrinsic Pathway for Apoptosis	0.084514	1.073
R-HSA-9833482	PKR-mediated signaling	0.138823	0.858
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea	0.239926	0.620
R-HSA-69002	DNA Replication Pre-Initiation	0.260007	0.585
R-HSA-140534	Caspase activation via Death Receptors in the presence of ligand	0.253271	0.596
R-HSA-165159	MTOR signalling	0.166036	0.780
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	0.148354	0.829
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.219813	0.658
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.163640	0.786
R-HSA-5683057	MAPK family signaling cascades	0.170818	0.767
R-HSA-1500931	Cell-Cell communication	0.222167	0.653
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.239888	0.620
R-HSA-450294	MAP kinase activation	0.266805	0.574
R-HSA-422475	Axon guidance	0.127700	0.894
R-HSA-9675108	Nervous system development	0.106003	0.975
R-HSA-375280	Amine ligand-binding receptors	0.176365	0.754
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.084514	1.073
R-HSA-435354	Zinc transporters	0.231128	0.636
R-HSA-425410	Metal ion SLC transporters	0.197302	0.705
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.085036	1.070
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.245295	0.610
R-HSA-187037	Signaling by NTRK1 (TRKA)	0.158116	0.801
R-HSA-168256	Immune System	0.256144	0.592
R-HSA-166520	Signaling by NTRKs	0.097673	1.010
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.256107	0.592
R-HSA-913531	Interferon Signaling	0.239888	0.620
R-HSA-162906	HIV Infection	0.155022	0.810
R-HSA-9856651	MITF-M-dependent gene expression	0.231542	0.635
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.260007	0.585
R-HSA-162599	Late Phase of HIV Life Cycle	0.086893	1.061
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.129068	0.889
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	0.207114	0.684
R-HSA-1266695	Interleukin-7 signaling	0.075977	1.119
R-HSA-982772	Growth hormone receptor signaling	0.067738	1.169
R-HSA-72306	tRNA processing	0.144745	0.839
R-HSA-3371556	Cellular response to heat stress	0.136754	0.864
R-HSA-162587	HIV Life Cycle	0.115042	0.939
R-HSA-5619102	SLC transporter disorders	0.135942	0.867
R-HSA-1280215	Cytokine Signaling in Immune system	0.080936	1.092
R-HSA-446652	Interleukin-1 family signaling	0.105218	0.978
R-HSA-449147	Signaling by Interleukins	0.153109	0.815
R-HSA-446728	Cell junction organization	0.270465	0.568
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	0.272185	0.565
R-HSA-9616222	Transcriptional regulation of granulopoiesis	0.272185	0.565
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	0.274778	0.561
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.274778	0.561
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.274778	0.561
R-HSA-1963642	PI3K events in ERBB2 signaling	0.274778	0.561
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to cla...	0.274778	0.561
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.274778	0.561
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.274778	0.561
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	0.274778	0.561
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	0.274778	0.561
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.275680	0.560
R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	0.279614	0.553
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	0.285299	0.545
R-HSA-73980	RNA Polymerase III Transcription Termination	0.285299	0.545
R-HSA-9613829	Chaperone Mediated Autophagy	0.285299	0.545
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.285299	0.545
R-HSA-210993	Tie2 Signaling	0.285299	0.545
R-HSA-5358508	Mismatch Repair	0.285299	0.545
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.287498	0.541
R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati...	0.288312	0.540
R-HSA-8878171	Transcriptional regulation by RUNX1	0.291044	0.536
R-HSA-5654710	PI-3K cascade:FGFR3	0.295669	0.529
R-HSA-937041	IKK complex recruitment mediated by RIP1	0.295669	0.529
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	0.295669	0.529
R-HSA-113510	E2F mediated regulation of DNA replication	0.295669	0.529
R-HSA-1834941	STING mediated induction of host immune responses	0.295669	0.529
R-HSA-5693606	DNA Double Strand Break Response	0.299043	0.524
R-HSA-5693538	Homology Directed Repair	0.303314	0.518
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun...	0.304399	0.517
R-HSA-9662360	Sensory processing of sound by inner hair cells of the cochlea	0.304399	0.517
R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex	0.305888	0.514
R-HSA-5654720	PI-3K cascade:FGFR4	0.305888	0.514
R-HSA-9934037	Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	0.305888	0.514
R-HSA-9609523	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	0.305888	0.514
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	0.305888	0.514
R-HSA-5620916	VxPx cargo-targeting to cilium	0.305888	0.514
R-HSA-140875	Common Pathway of Fibrin Clot Formation	0.305888	0.514
R-HSA-373753	Nephrin family interactions	0.305888	0.514
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	0.307275	0.512
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.307275	0.512
R-HSA-9764560	Regulation of CDH1 Gene Transcription	0.315088	0.502
R-HSA-448424	Interleukin-17 signaling	0.315088	0.502
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.315088	0.502
R-HSA-5602498	MyD88 deficiency (TLR2/4)	0.315960	0.500
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.315960	0.500
R-HSA-198753	ERK/MAPK targets	0.315960	0.500
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.315960	0.500
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.315960	0.500
R-HSA-9819196	Zygotic genome activation (ZGA)	0.315960	0.500
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.319170	0.496
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.319170	0.496
R-HSA-73894	DNA Repair	0.320266	0.494
R-HSA-453276	Regulation of mitotic cell cycle	0.320420	0.494
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	0.320420	0.494
R-HSA-427413	NoRC negatively regulates rRNA expression	0.320420	0.494
R-HSA-9924644	Developmental Lineages of the Mammary Gland	0.325741	0.487
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.325741	0.487
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.325741	0.487
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.325886	0.487
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	0.325886	0.487
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.325886	0.487
R-HSA-947581	Molybdenum cofactor biosynthesis	0.325886	0.487
R-HSA-174403	Glutathione synthesis and recycling	0.325886	0.487
R-HSA-9034015	Signaling by NTRK3 (TRKC)	0.325886	0.487
R-HSA-168255	Influenza Infection	0.327878	0.484
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	0.331052	0.480
R-HSA-2559583	Cellular Senescence	0.331161	0.480
R-HSA-5654689	PI-3K cascade:FGFR1	0.335669	0.474
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.335669	0.474
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.335669	0.474
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in ...	0.335669	0.474
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	0.335669	0.474
R-HSA-69473	G2/M DNA damage checkpoint	0.336350	0.473
R-HSA-201681	TCF dependent signaling in response to WNT	0.341020	0.467
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.341637	0.466
R-HSA-8852135	Protein ubiquitination	0.341637	0.466
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	0.341637	0.466
R-HSA-114608	Platelet degranulation	0.342966	0.465
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	0.345311	0.462
R-HSA-9020591	Interleukin-12 signaling	0.346910	0.460
R-HSA-5619115	Disorders of transmembrane transporters	0.350773	0.455
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.354813	0.450
R-HSA-9665686	Signaling by ERBB2 TMD/JMD mutants	0.354813	0.450
R-HSA-9821993	Replacement of protamines by nucleosomes in the male pronucleus	0.354813	0.450
R-HSA-5669034	TNFs bind their physiological receptors	0.354813	0.450
R-HSA-9659379	Sensory processing of sound	0.362644	0.441
R-HSA-5654695	PI-3K cascade:FGFR2	0.364178	0.439
R-HSA-9932444	ATP-dependent chromatin remodelers	0.364178	0.439
R-HSA-9932451	SWI/SNF chromatin remodelers	0.364178	0.439
R-HSA-1482801	Acyl chain remodelling of PS	0.364178	0.439
R-HSA-3214842	HDMs demethylate histones	0.364178	0.439
R-HSA-2160916	Hyaluronan degradation	0.364178	0.439
R-HSA-400685	Sema4D in semaphorin signaling	0.364178	0.439
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.367857	0.434
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.370641	0.431
R-HSA-5693607	Processing of DNA double-strand break ends	0.373054	0.428
R-HSA-977225	Amyloid fiber formation	0.373054	0.428
R-HSA-9703465	Signaling by FLT3 fusion proteins	0.373407	0.428
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	0.373407	0.428
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.373407	0.428
R-HSA-1643713	Signaling by EGFR in Cancer	0.373407	0.428
R-HSA-3295583	TRP channels	0.373407	0.428
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.373407	0.428
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	0.373407	0.428
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.378234	0.422
R-HSA-174414	Processive synthesis on the C-strand of the telomere	0.382503	0.417
R-HSA-171306	Packaging Of Telomere Ends	0.382503	0.417
R-HSA-73863	RNA Polymerase I Transcription Termination	0.382503	0.417
R-HSA-73728	RNA Polymerase I Promoter Opening	0.382503	0.417
R-HSA-5357956	TNFR1-induced NF-kappa-B signaling pathway	0.382503	0.417
R-HSA-5655332	Signaling by FGFR3 in disease	0.382503	0.417
R-HSA-264876	Insulin processing	0.382503	0.417
R-HSA-9006115	Signaling by NTRK2 (TRKB)	0.382503	0.417
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.388539	0.411
R-HSA-9619483	Activation of AMPK downstream of NMDARs	0.391468	0.407
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	0.391468	0.407
R-HSA-171319	Telomere Extension By Telomerase	0.391468	0.407
R-HSA-1500620	Meiosis	0.393664	0.405
R-HSA-5358351	Signaling by Hedgehog	0.394197	0.404
R-HSA-5334118	DNA methylation	0.400303	0.398
R-HSA-9615710	Late endosomal microautophagy	0.400303	0.398
R-HSA-5654708	Downstream signaling of activated FGFR3	0.400303	0.398
R-HSA-5656169	Termination of translesion DNA synthesis	0.400303	0.398
R-HSA-9759475	Regulation of CDH11 Expression and Function	0.400303	0.398
R-HSA-381038	XBP1(S) activates chaperone genes	0.403855	0.394
R-HSA-447115	Interleukin-12 family signaling	0.408919	0.388
R-HSA-76046	RNA Polymerase III Transcription Initiation	0.409010	0.388
R-HSA-9687139	Aberrant regulation of mitotic cell cycle due to RB1 defects	0.409010	0.388
R-HSA-5654716	Downstream signaling of activated FGFR4	0.409010	0.388
R-HSA-68962	Activation of the pre-replicative complex	0.409010	0.388
R-HSA-114452	Activation of BH3-only proteins	0.409010	0.388
R-HSA-162588	Budding and maturation of HIV virion	0.417591	0.379
R-HSA-9913351	Formation of the dystrophin-glycoprotein complex (DGC)	0.417591	0.379
R-HSA-399719	Trafficking of AMPA receptors	0.417591	0.379
R-HSA-186763	Downstream signal transduction	0.417591	0.379
R-HSA-6805567	Keratinization	0.419715	0.377
R-HSA-73884	Base Excision Repair	0.423987	0.373
R-HSA-1538133	G0 and Early G1	0.426049	0.371
R-HSA-4791275	Signaling by WNT in cancer	0.426049	0.371
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected ...	0.426049	0.371
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.426049	0.371
R-HSA-1266738	Developmental Biology	0.428667	0.368
R-HSA-199977	ER to Golgi Anterograde Transport	0.432911	0.364
R-HSA-381070	IRE1alpha activates chaperones	0.433921	0.363
R-HSA-354192	Integrin signaling	0.434383	0.362
R-HSA-397795	G-protein beta:gamma signalling	0.434383	0.362
R-HSA-68616	Assembly of the ORC complex at the origin of replication	0.434383	0.362
R-HSA-9764260	Regulation of Expression and Function of Type II Classical Cadherins	0.434383	0.362
R-HSA-399721	Glutamate binding, activation of AMPA receptors and synaptic plasticity	0.434383	0.362
R-HSA-9930044	Nuclear RNA decay	0.434383	0.362
R-HSA-9730414	MITF-M-regulated melanocyte development	0.442345	0.354
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	0.442598	0.354
R-HSA-1482788	Acyl chain remodelling of PC	0.442598	0.354
R-HSA-9619665	EGR2 and SOX10-mediated initiation of Schwann cell myelination	0.442598	0.354
R-HSA-68867	Assembly of the pre-replicative complex	0.443763	0.353
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	0.446452	0.350
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian expression	0.450694	0.346
R-HSA-9843970	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	0.450694	0.346
R-HSA-2142845	Hyaluronan metabolism	0.450694	0.346
R-HSA-5686938	Regulation of TLR by endogenous ligand	0.450694	0.346
R-HSA-168638	NOD1/2 Signaling Pathway	0.450694	0.346
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected ...	0.450694	0.346
R-HSA-5654696	Downstream signaling of activated FGFR2	0.458672	0.338
R-HSA-5654687	Downstream signaling of activated FGFR1	0.458672	0.338
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes	0.458672	0.338
R-HSA-1482839	Acyl chain remodelling of PE	0.458672	0.338
R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZ...	0.458672	0.338
R-HSA-6807878	COPI-mediated anterograde transport	0.463160	0.334
R-HSA-212300	PRC2 methylates histones and DNA	0.466535	0.331
R-HSA-9682385	FLT3 signaling in disease	0.466535	0.331
R-HSA-8941326	RUNX2 regulates bone development	0.466535	0.331
R-HSA-69205	G1/S-Specific Transcription	0.466535	0.331
R-HSA-6804757	Regulation of TP53 Degradation	0.466535	0.331
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	0.466535	0.331
R-HSA-163560	Triglyceride catabolism	0.466535	0.331
R-HSA-8878159	Transcriptional regulation by RUNX3	0.467947	0.330
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.467947	0.330
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.472709	0.325
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.472709	0.325
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.472709	0.325
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.474285	0.324
R-HSA-427359	SIRT1 negatively regulates rRNA expression	0.474285	0.324
R-HSA-4641258	Degradation of DVL	0.474285	0.324
R-HSA-933541	TRAF6 mediated IRF7 activation	0.474285	0.324
R-HSA-110331	Cleavage of the damaged purine	0.474285	0.324
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.474285	0.324
R-HSA-9614085	FOXO-mediated transcription	0.477445	0.321
R-HSA-8875878	MET promotes cell motility	0.481922	0.317
R-HSA-73927	Depurination	0.481922	0.317
R-HSA-9958790	SLC-mediated transport of inorganic anions	0.481922	0.317
R-HSA-1257604	PIP3 activates AKT signaling	0.487303	0.312
R-HSA-8953750	Transcriptional Regulation by E2F6	0.489449	0.310
R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.489449	0.310
R-HSA-201556	Signaling by ALK	0.489449	0.310
R-HSA-9705683	SARS-CoV-2-host interactions	0.489874	0.310
R-HSA-9842860	Regulation of endogenous retroelements	0.491498	0.308
R-HSA-8941858	Regulation of RUNX3 expression and activity	0.496867	0.304
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	0.496867	0.304
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.496867	0.304
R-HSA-9604323	Negative regulation of NOTCH4 signaling	0.496867	0.304
R-HSA-1251985	Nuclear signaling by ERBB4	0.496867	0.304
R-HSA-202433	Generation of second messenger molecules	0.496867	0.304
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated gene...	0.504177	0.297
R-HSA-9821002	Chromatin modifications during the maternal to zygotic transition (MZT)	0.504177	0.297
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.504177	0.297
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	0.504177	0.297
R-HSA-8853884	Transcriptional Regulation by VENTX	0.504177	0.297
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa...	0.504177	0.297
R-HSA-5423646	Aflatoxin activation and detoxification	0.504177	0.297
R-HSA-5696398	Nucleotide Excision Repair	0.509862	0.293
R-HSA-5674135	MAP2K and MAPK activation	0.511382	0.291
R-HSA-9656223	Signaling by RAF1 mutants	0.511382	0.291
R-HSA-5655302	Signaling by FGFR1 in disease	0.511382	0.291
R-HSA-110329	Cleavage of the damaged pyrimidine	0.518483	0.285
R-HSA-73928	Depyrimidination	0.518483	0.285
R-HSA-2672351	Stimuli-sensing channels	0.523349	0.281
R-HSA-8854214	TBC/RABGAPs	0.525480	0.279
R-HSA-5654743	Signaling by FGFR4	0.525480	0.279
R-HSA-1433557	Signaling by SCF-KIT	0.525480	0.279
R-HSA-9909648	Regulation of PD-L1(CD274) expression	0.528654	0.277
R-HSA-69236	G1 Phase	0.532377	0.274
R-HSA-69231	Cyclin D associated events in G1	0.532377	0.274
R-HSA-190828	Gap junction trafficking	0.532377	0.274
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.539174	0.268
R-HSA-4608870	Asymmetric localization of PCP proteins	0.539174	0.268
R-HSA-5654741	Signaling by FGFR3	0.539174	0.268
R-HSA-72165	mRNA Splicing - Minor Pathway	0.545872	0.263
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	0.545872	0.263
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.545872	0.263
R-HSA-9649948	Signaling downstream of RAS mutants	0.545872	0.263
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.545872	0.263
R-HSA-6802949	Signaling by RAS mutants	0.545872	0.263
R-HSA-5357905	Regulation of TNFR1 signaling	0.545872	0.263
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	0.552473	0.258
R-HSA-70263	Gluconeogenesis	0.558979	0.253
R-HSA-9031628	NGF-stimulated transcription	0.558979	0.253
R-HSA-909733	Interferon alpha/beta signaling	0.562294	0.250
R-HSA-212165	Epigenetic regulation of gene expression	0.562386	0.250
R-HSA-157858	Gap junction trafficking and regulation	0.565391	0.248
R-HSA-3700989	Transcriptional Regulation by TP53	0.566439	0.247
R-HSA-72737	Cap-dependent Translation Initiation	0.566479	0.247
R-HSA-72613	Eukaryotic Translation Initiation	0.566479	0.247
R-HSA-9007101	Rab regulation of trafficking	0.570635	0.244
R-HSA-5688426	Deubiquitination	0.570810	0.244
R-HSA-5658442	Regulation of RAS by GAPs	0.571710	0.243
R-HSA-5655253	Signaling by FGFR2 in disease	0.571710	0.243
R-HSA-912446	Meiotic recombination	0.577937	0.238
R-HSA-112382	Formation of RNA Pol II elongation complex	0.584074	0.234
R-HSA-9692916	SARS-CoV-1 activates/modulates innate immune responses	0.584074	0.234
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins ...	0.590123	0.229
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.590123	0.229
R-HSA-8956320	Nucleotide biosynthesis	0.590123	0.229
R-HSA-72649	Translation initiation complex formation	0.596083	0.225
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	0.596083	0.225
R-HSA-73929	Base-Excision Repair, AP Site Formation	0.596083	0.225
R-HSA-1280218	Adaptive Immune System	0.596879	0.224
R-HSA-3214815	HDACs deacetylate histones	0.601958	0.220
R-HSA-9753281	Paracetamol ADME	0.601958	0.220
R-HSA-9012852	Signaling by NOTCH3	0.601958	0.220
R-HSA-69206	G1/S Transition	0.606740	0.217
R-HSA-72702	Ribosomal scanning and start codon recognition	0.607747	0.216
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.607747	0.216
R-HSA-75893	TNF signaling	0.607747	0.216
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.607747	0.216
R-HSA-5654736	Signaling by FGFR1	0.607747	0.216
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.607747	0.216
R-HSA-9759476	Regulation of Homotypic Cell-Cell Adhesion	0.608558	0.216
R-HSA-9006925	Intracellular signaling by second messengers	0.610070	0.215
R-HSA-74160	Gene expression (Transcription)	0.611245	0.214
R-HSA-69481	G2/M Checkpoints	0.614445	0.212
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.620970	0.207
R-HSA-389948	Co-inhibition by PD-1	0.620970	0.207
R-HSA-8979227	Triglyceride metabolism	0.624617	0.204
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.624617	0.204
R-HSA-948021	Transport to the Golgi and subsequent modification	0.627076	0.203
R-HSA-1474165	Reproduction	0.629509	0.201
R-HSA-983189	Kinesins	0.630078	0.201
R-HSA-8943724	Regulation of PTEN gene transcription	0.630078	0.201
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription	0.630078	0.201
R-HSA-156590	Glutathione conjugation	0.630078	0.201
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.630078	0.201
R-HSA-375165	NCAM signaling for neurite out-growth	0.640764	0.193
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.640764	0.193
R-HSA-186797	Signaling by PDGF	0.640764	0.193
R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases	0.645991	0.190
R-HSA-8848021	Signaling by PTK6	0.645991	0.190
R-HSA-373755	Semaphorin interactions	0.645991	0.190
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali...	0.651143	0.186
R-HSA-9018519	Estrogen-dependent gene expression	0.654766	0.184
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	0.659445	0.181
R-HSA-381119	Unfolded Protein Response (UPR)	0.665164	0.177
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.666153	0.176
R-HSA-418990	Adherens junctions interactions	0.676232	0.170
R-HSA-9843940	Regulation of endogenous retroelements by KRAB-ZFP proteins	0.680521	0.167
R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.680521	0.167
R-HSA-204005	COPII-mediated vesicle transport	0.680521	0.167
R-HSA-69202	Cyclin E associated events during G1/S transition	0.680521	0.167
R-HSA-195721	Signaling by WNT	0.683522	0.165
R-HSA-8951664	Neddylation	0.684394	0.165
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.685172	0.164
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	0.689755	0.161
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.689755	0.161
R-HSA-453279	Mitotic G1 phase and G1/S transition	0.691665	0.160
R-HSA-69052	Switching of origins to a post-replicative state	0.694272	0.158
R-HSA-71387	Metabolism of carbohydrates and carbohydrate derivatives	0.696201	0.157
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.698724	0.156
R-HSA-1226099	Signaling by FGFR in disease	0.698724	0.156
R-HSA-9013694	Signaling by NOTCH4	0.698724	0.156
R-HSA-1236394	Signaling by ERBB4	0.698724	0.156
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.703111	0.153
R-HSA-5689603	UCH proteinases	0.707435	0.150
R-HSA-1980143	Signaling by NOTCH1	0.707435	0.150
R-HSA-4086400	PCP/CE pathway	0.715894	0.145
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.715894	0.145
R-HSA-216083	Integrin cell surface interactions	0.715894	0.145
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes	0.716420	0.145
R-HSA-6806834	Signaling by MET	0.724110	0.140
R-HSA-5654738	Signaling by FGFR2	0.724110	0.140
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.728129	0.138
R-HSA-157118	Signaling by NOTCH	0.732548	0.135
R-HSA-9006936	Signaling by TGFB family members	0.733877	0.134
R-HSA-5633007	Regulation of TP53 Activity	0.733877	0.134
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	0.735993	0.133
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	0.747366	0.126
R-HSA-2262752	Cellular responses to stress	0.754117	0.123
R-HSA-390466	Chaperonin-mediated protein folding	0.754676	0.122
R-HSA-1474244	Extracellular matrix organization	0.754849	0.122
R-HSA-421270	Cell-cell junction organization	0.757689	0.121
R-HSA-9663891	Selective autophagy	0.758251	0.120
R-HSA-1236974	ER-Phagosome pathway	0.761775	0.118
R-HSA-388841	Regulation of T cell activation by CD28 family	0.768474	0.114
R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.768669	0.114
R-HSA-5689880	Ub-specific processing proteases	0.771091	0.113
R-HSA-9764265	Regulation of CDH1 Expression and Function	0.771091	0.113
R-HSA-9764274	Regulation of Expression and Function of Type I Classical Cadherins	0.771091	0.113
R-HSA-391251	Protein folding	0.775365	0.110
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.776022	0.110
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messenge...	0.778640	0.109
R-HSA-1474290	Collagen formation	0.781867	0.107
R-HSA-416476	G alpha (q) signalling events	0.784916	0.105
R-HSA-9694516	SARS-CoV-2 Infection	0.788219	0.103
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.791272	0.102
R-HSA-8957275	Post-translational protein phosphorylation	0.797316	0.098
R-HSA-190236	Signaling by FGFR	0.797316	0.098
R-HSA-597592	Post-translational protein modification	0.802385	0.096
R-HSA-76002	Platelet activation, signaling and aggregation	0.804105	0.095
R-HSA-9020702	Interleukin-1 signaling	0.806057	0.094
R-HSA-983712	Ion channel transport	0.808011	0.093
R-HSA-8953897	Cellular responses to stimuli	0.810053	0.091
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	0.814316	0.089
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	0.814422	0.089
R-HSA-9860931	Response of endothelial cells to shear stress	0.814422	0.089
R-HSA-5619507	Activation of HOX genes during differentiation	0.817130	0.088
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogen...	0.817130	0.088
R-HSA-9833110	RSV-host interactions	0.817130	0.088
R-HSA-9692914	SARS-CoV-1-host interactions	0.822428	0.085
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	0.827573	0.082
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	0.827573	0.082
R-HSA-1236975	Antigen processing-Cross presentation	0.827573	0.082
R-HSA-202403	TCR signaling	0.832570	0.080
R-HSA-376176	Signaling by ROBO receptors	0.835883	0.078
R-HSA-1912422	Pre-NOTCH Expression and Processing	0.839797	0.076
R-HSA-9855142	Cellular responses to mechanical stimuli	0.842136	0.075
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l...	0.844441	0.073
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.848951	0.071
R-HSA-1592230	Mitochondrial biogenesis	0.853331	0.069
R-HSA-2980736	Peptide hormone metabolism	0.853331	0.069
R-HSA-397014	Muscle contraction	0.853504	0.069
R-HSA-8878166	Transcriptional regulation by RUNX2	0.857584	0.067
R-HSA-2132295	MHC class II antigen presentation	0.865726	0.063
R-HSA-9851695	Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes	0.871526	0.060
R-HSA-9841922	MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi...	0.871526	0.060
R-HSA-9818564	Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	0.871526	0.060
R-HSA-194138	Signaling by VEGF	0.871526	0.060
R-HSA-112315	Transmission across Chemical Synapses	0.878518	0.056
R-HSA-8856688	Golgi-to-ER retrograde transport	0.885803	0.053
R-HSA-1474228	Degradation of the extracellular matrix	0.885803	0.053
R-HSA-8939211	ESR-mediated signaling	0.890279	0.050
R-HSA-202733	Cell surface interactions at the vascular wall	0.890279	0.050
R-HSA-3858494	Beta-catenin independent WNT signaling	0.893912	0.049
R-HSA-9820952	Respiratory Syncytial Virus Infection Pathway	0.895464	0.048
R-HSA-388396	GPCR downstream signalling	0.897508	0.047
R-HSA-6807070	PTEN Regulation	0.898500	0.046
R-HSA-1632852	Macroautophagy	0.901448	0.045
R-HSA-9758941	Gastrulation	0.913693	0.039
R-HSA-9609507	Protein localization	0.918638	0.037
R-HSA-6798695	Neutrophil degranulation	0.920090	0.036
R-HSA-73857	RNA Polymerase II Transcription	0.920823	0.036
R-HSA-1989781	PPARA activates gene expression	0.921003	0.036
R-HSA-9612973	Autophagy	0.922160	0.035
R-HSA-400206	Regulation of lipid metabolism by PPARalpha	0.923300	0.035
R-HSA-9711097	Cellular response to starvation	0.924423	0.034
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.924423	0.034
R-HSA-9679506	SARS-CoV Infections	0.925045	0.034
R-HSA-112316	Neuronal System	0.928101	0.032
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.937619	0.028
R-HSA-9678108	SARS-CoV-1 Infection	0.942060	0.026
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.942743	0.026
R-HSA-1643685	Disease	0.944479	0.025
R-HSA-425407	SLC-mediated transmembrane transport	0.944571	0.025
R-HSA-372790	Signaling by GPCR	0.945347	0.024
R-HSA-375276	Peptide ligand-binding receptors	0.950752	0.022
R-HSA-9824446	Viral Infection Pathways	0.951034	0.022
R-HSA-109582	Hemostasis	0.951476	0.022
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.952187	0.021
R-HSA-5617833	Cilium Assembly	0.953580	0.021
R-HSA-212436	Generic Transcription Pathway	0.955323	0.020
R-HSA-1630316	Glycosaminoglycan metabolism	0.955594	0.020
R-HSA-446203	Asparagine N-linked glycosylation	0.957830	0.019
R-HSA-1852241	Organelle biogenesis and maintenance	0.959715	0.018
R-HSA-428157	Sphingolipid metabolism	0.960550	0.017
R-HSA-1483206	Glycerophospholipid biosynthesis	0.961700	0.017
R-HSA-9748784	Drug ADME	0.969778	0.013
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.974324	0.011
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.974701	0.011
R-HSA-72312	rRNA processing	0.975440	0.011
R-HSA-9006931	Signaling by Nuclear Receptors	0.976505	0.010
R-HSA-15869	Metabolism of nucleotides	0.976855	0.010
R-HSA-156580	Phase II - Conjugation of compounds	0.977862	0.010
R-HSA-168249	Innate Immune System	0.979536	0.009
R-HSA-392499	Metabolism of proteins	0.980937	0.008
R-HSA-9824443	Parasitic Infection Pathways	0.988136	0.005
R-HSA-9658195	Leishmania infection	0.988136	0.005
R-HSA-72766	Translation	0.990070	0.004
R-HSA-1483257	Phospholipid metabolism	0.990367	0.004
R-HSA-500792	GPCR ligand binding	0.993947	0.003
R-HSA-196854	Metabolism of vitamins and cofactors	0.996558	0.001
R-HSA-418594	G alpha (i) signalling events	0.998219	0.001
R-HSA-5663205	Infectious disease	0.999112	0.000
R-HSA-382551	Transport of small molecules	0.999122	0.000
R-HSA-211859	Biological oxidations	0.999689	0.000
R-HSA-556833	Metabolism of lipids	1.000000	0.000
R-HSA-9709957	Sensory Perception	1.000000	0.000
R-HSA-1430728	Metabolism	1.000000	0.000

Download

kinase	JSD_mean	pearson_surrounding	kinase_max_IC_position	max_position_JSD
JNK2	0.854	0.527	1	0.869
GAK	0.853	0.096	1	0.728
JNK3	0.849	0.509	1	0.887
P38B	0.847	0.502	1	0.884
P38A	0.843	0.468	1	0.905
P38G	0.839	0.508	1	0.847
CDK1	0.838	0.529	1	0.898
HIPK1	0.837	0.473	1	0.881
PASK	0.837	0.166	-3	0.884
GCK	0.836	0.032	1	0.650
P38D	0.836	0.500	1	0.838
TAK1	0.835	-0.048	1	0.657
MAK	0.835	0.390	-2	0.690
VRK2	0.835	-0.092	1	0.737
CLK3	0.834	0.463	1	0.899
PRP4	0.834	0.294	-3	0.746
NLK	0.833	0.433	1	0.874
PKR	0.832	-0.049	1	0.686
JNK1	0.832	0.457	1	0.874
MOS	0.832	0.231	1	0.766
MPSK1	0.832	0.128	1	0.689
LRRK2	0.831	-0.080	2	0.787
TNIK	0.830	-0.018	3	0.848
ICK	0.830	0.277	-3	0.859
DYRK2	0.829	0.483	1	0.877
ERK1	0.828	0.486	1	0.876
MINK	0.828	-0.068	1	0.610
VRK1	0.828	-0.166	2	0.794
BMPR1B	0.828	0.180	1	0.721
KHS2	0.828	0.036	1	0.628
TAO3	0.827	0.016	1	0.657
ERK2	0.827	0.451	1	0.895
DAPK2	0.826	0.017	-3	0.866
CDK5	0.826	0.462	1	0.908
HPK1	0.826	0.004	1	0.629
MST3	0.826	0.031	2	0.773
CDKL1	0.826	0.183	-3	0.834
ALK4	0.826	0.028	-2	0.759
ALPHAK3	0.825	0.001	-1	0.761
GRK7	0.825	0.217	1	0.686
NIK	0.825	-0.034	-3	0.870
PDK1	0.825	-0.062	1	0.645
LKB1	0.825	-0.050	-3	0.799
OSR1	0.825	-0.027	2	0.746
HIPK2	0.825	0.525	1	0.857
KHS1	0.825	-0.031	1	0.602
BMPR2	0.824	-0.119	-2	0.782
EEF2K	0.824	-0.045	3	0.816
TTK	0.823	-0.069	-2	0.721
MEK1	0.823	-0.146	2	0.794
CAMLCK	0.822	0.004	-2	0.739
MEKK2	0.822	-0.093	2	0.739
CDK14	0.822	0.468	1	0.879
CDK3	0.821	0.458	1	0.865
MEK5	0.821	-0.170	2	0.767
LATS1	0.821	0.062	-3	0.863
MOK	0.821	0.335	1	0.860
TAO2	0.821	-0.104	2	0.780
HGK	0.821	-0.081	3	0.846
PBK	0.821	-0.014	1	0.653
ERK5	0.820	0.273	1	0.859
DLK	0.819	-0.074	1	0.680
MAP3K15	0.819	-0.119	1	0.596
DYRK1A	0.819	0.397	1	0.895
ASK1	0.819	-0.195	1	0.585
BRAF	0.819	-0.153	-4	0.815
MST2	0.819	-0.134	1	0.632
PRPK	0.818	-0.060	-1	0.852
ALK2	0.818	0.040	-2	0.755
HIPK3	0.818	0.420	1	0.852
CDK18	0.818	0.503	1	0.876
CDK17	0.817	0.492	1	0.851
DMPK1	0.817	0.055	-3	0.797
BIKE	0.817	-0.050	1	0.620
CAMK1B	0.817	0.021	-3	0.867
NEK5	0.817	-0.164	1	0.656
CDK6	0.817	0.438	1	0.865
DYRK4	0.817	0.485	1	0.871
DYRK1B	0.817	0.444	1	0.875
TGFBR1	0.816	0.045	-2	0.741
DAPK3	0.816	0.024	-3	0.830
NEK1	0.816	-0.228	1	0.621
MEKK6	0.816	-0.131	1	0.639
MST1	0.815	-0.168	1	0.612
CDK4	0.815	0.444	1	0.866
MYO3B	0.815	-0.095	2	0.759
SKMLCK	0.815	0.069	-2	0.778
CDK16	0.815	0.468	1	0.859
ATR	0.815	-0.007	1	0.692
MEKK3	0.815	-0.029	1	0.642
CAMKK2	0.814	-0.177	-2	0.647
MYO3A	0.813	-0.116	1	0.606
NEK11	0.813	-0.122	1	0.633
CAMKK1	0.812	-0.206	-2	0.655
HIPK4	0.812	0.376	1	0.855
ROCK2	0.812	0.031	-3	0.819
NEK8	0.811	-0.164	2	0.750
ACVR2B	0.811	0.030	-2	0.711
SRPK1	0.811	0.330	-3	0.800
BMPR1A	0.810	0.094	1	0.691
ANKRD3	0.810	-0.172	1	0.674
CLK4	0.810	0.288	-3	0.806
CDK10	0.809	0.467	1	0.879
CDK13	0.809	0.456	1	0.886
CDKL5	0.809	0.196	-3	0.826
DAPK1	0.809	0.040	-3	0.822
AAK1	0.809	-0.010	1	0.554
DYRK3	0.808	0.349	1	0.855
CDK12	0.808	0.457	1	0.871
CDK2	0.808	0.351	1	0.897
SMMLCK	0.808	-0.031	-3	0.832
COT	0.808	0.132	2	0.828
CLK2	0.808	0.384	-3	0.798
YSK4	0.807	-0.154	1	0.605
ACVR2A	0.807	-0.003	-2	0.695
SRPK3	0.806	0.264	-3	0.775
YSK1	0.806	-0.162	2	0.740
GRK5	0.806	0.022	-3	0.858
MEKK1	0.806	-0.233	1	0.619
HASPIN	0.805	0.061	-1	0.720
GSK3A	0.805	0.202	4	0.525
STLK3	0.804	-0.236	1	0.568
CDK7	0.804	0.447	1	0.900
MLK2	0.804	-0.131	2	0.757
ERK7	0.804	0.144	2	0.490
ZAK	0.804	-0.169	1	0.600
NEK4	0.804	-0.239	1	0.602
PIM1	0.804	0.106	-3	0.833
CHAK2	0.804	0.020	-1	0.829
LOK	0.804	-0.109	-2	0.656
GRK1	0.803	0.271	-2	0.835
GRK2	0.803	0.075	-2	0.712
RAF1	0.803	-0.109	1	0.667
GRK6	0.803	0.017	1	0.701
PIM3	0.803	0.095	-3	0.869
CDK8	0.802	0.447	1	0.874
BUB1	0.801	0.070	-5	0.795
KIS	0.801	0.609	1	0.890
MEK2	0.800	-0.328	2	0.763
MTOR	0.800	0.154	1	0.731
CDC7	0.799	0.071	1	0.737
SLK	0.798	-0.076	-2	0.634
CLK1	0.798	0.304	-3	0.778
MLK1	0.798	-0.088	2	0.742
CDK9	0.798	0.418	1	0.884
CAMK2G	0.798	-0.060	2	0.765
TLK2	0.798	-0.093	1	0.625
PIM2	0.797	0.077	-3	0.783
WNK1	0.796	-0.027	-2	0.797
PINK1	0.796	0.006	1	0.799
PERK	0.796	-0.168	-2	0.746
GSK3B	0.796	0.098	4	0.519
MASTL	0.795	-0.206	-2	0.735
PLK1	0.794	-0.129	-2	0.675
WNK4	0.793	-0.136	-2	0.786
PKN3	0.793	-0.016	-3	0.841
CRIK	0.793	0.057	-3	0.759
ROCK1	0.793	-0.000	-3	0.783
NUAK2	0.792	0.039	-3	0.864
PDHK4	0.792	-0.235	1	0.710
DCAMKL1	0.792	-0.017	-3	0.811
RIPK1	0.792	-0.144	1	0.641
CDK19	0.792	0.453	1	0.858
MLK3	0.792	-0.038	2	0.659
AMPKA1	0.791	-0.032	-3	0.865
P70S6KB	0.791	0.034	-3	0.819
TAO1	0.791	-0.160	1	0.557
TLK1	0.790	-0.118	-2	0.764
TSSK2	0.790	-0.095	-5	0.830
RIPK3	0.789	-0.080	3	0.682
PKN2	0.789	-0.005	-3	0.850
MST4	0.789	-0.004	2	0.797
CK1D	0.789	0.222	-3	0.612
DRAK1	0.789	-0.051	1	0.673
PKCD	0.788	-0.026	2	0.711
MRCKA	0.788	0.005	-3	0.783
AKT2	0.788	0.083	-3	0.743
MLK4	0.788	-0.078	2	0.647
IRAK4	0.788	-0.159	1	0.624
MRCKB	0.788	0.017	-3	0.773
HRI	0.788	-0.257	-2	0.739
NEK9	0.787	-0.264	2	0.775
DSTYK	0.787	-0.068	2	0.826
SRPK2	0.786	0.274	-3	0.730
MYLK4	0.785	0.005	-2	0.676
DNAPK	0.784	-0.049	1	0.546
RSK2	0.784	0.085	-3	0.808
HUNK	0.784	-0.113	2	0.774
SGK3	0.784	0.022	-3	0.800
SGK1	0.782	0.078	-3	0.678
SMG1	0.782	-0.060	1	0.638
PDHK1	0.782	-0.315	1	0.666
TGFBR2	0.782	-0.065	-2	0.709
GRK3	0.782	0.091	-2	0.699
TSSK1	0.782	-0.055	-3	0.878
IRE1	0.781	-0.067	1	0.649
GRK4	0.780	0.040	-2	0.813
DCAMKL2	0.780	-0.072	-3	0.820
CHAK1	0.780	-0.148	2	0.721
NEK2	0.780	-0.226	2	0.751
AMPKA2	0.779	-0.025	-3	0.842
CHK1	0.779	-0.114	-3	0.820
PAK1	0.779	-0.034	-2	0.687
ATM	0.778	-0.059	1	0.624
MARK4	0.778	-0.100	4	0.818
P90RSK	0.778	0.047	-3	0.806
CAMK2B	0.777	0.014	2	0.751
PKCZ	0.777	-0.053	2	0.711
CAMK2D	0.777	-0.079	-3	0.837
NEK7	0.777	-0.182	-3	0.805
PAK2	0.776	-0.086	-2	0.672
NDR1	0.776	0.000	-3	0.853
PDHK3_TYR	0.776	0.184	4	0.905
TBK1	0.776	-0.170	1	0.539
CAMK2A	0.776	0.042	2	0.755
NEK6	0.776	-0.090	-2	0.746
CK1A2	0.776	0.163	-3	0.616
PKCA	0.775	-0.028	2	0.648
IKKB	0.775	-0.054	-2	0.680
IRE2	0.775	-0.107	2	0.690
PLK3	0.775	-0.164	2	0.731
CHK2	0.774	0.027	-3	0.687
CK1E	0.774	0.198	-3	0.657
NEK3	0.774	-0.262	1	0.580
RSK4	0.774	0.084	-3	0.793
PKCB	0.774	-0.012	2	0.655
AURB	0.773	-0.010	-2	0.557
WNK3	0.773	-0.253	1	0.640
MELK	0.772	-0.071	-3	0.816
CAMK4	0.772	-0.102	-3	0.833
PDHK4_TYR	0.772	0.160	2	0.839
AKT1	0.772	0.034	-3	0.756
TTBK2	0.772	-0.112	2	0.638
MSK1	0.771	0.033	-3	0.787
PKACG	0.771	0.009	-2	0.644
PKCH	0.771	-0.069	2	0.641
AURC	0.771	0.052	-2	0.564
ULK2	0.771	-0.264	2	0.730
NDR2	0.770	0.068	-3	0.866
MAPKAPK3	0.770	-0.016	-3	0.796
CAMK1D	0.770	-0.011	-3	0.729
PKACB	0.769	0.064	-2	0.570
MAP2K6_TYR	0.769	0.119	-1	0.856
PRKD3	0.769	0.026	-3	0.772
PRKD1	0.769	0.042	-3	0.832
BMPR2_TYR	0.768	0.113	-1	0.858
IKKA	0.768	-0.023	-2	0.679
PKCG	0.768	-0.030	2	0.652
MAP2K4_TYR	0.768	0.079	-1	0.857
AURA	0.768	-0.014	-2	0.538
IKKE	0.768	-0.186	1	0.533
CAMK1G	0.768	-0.022	-3	0.787
PKCE	0.768	0.003	2	0.640
PAK3	0.768	-0.090	-2	0.675
PDHK1_TYR	0.768	0.104	-1	0.875
SBK	0.767	0.098	-3	0.632
PLK2	0.767	-0.069	-3	0.742
PKG2	0.766	-0.005	-2	0.572
TESK1_TYR	0.766	0.009	3	0.833
PRKD2	0.766	0.073	-3	0.799
RSK3	0.765	0.027	-3	0.795
CK2A2	0.765	0.047	1	0.661
STK33	0.765	-0.143	2	0.559
QIK	0.765	-0.133	-3	0.834
IRAK1	0.765	-0.302	-1	0.739
NIM1	0.764	-0.123	3	0.708
SSTK	0.764	-0.097	4	0.788
QSK	0.764	-0.053	4	0.793
MSK2	0.763	-0.003	-3	0.787
LATS2	0.763	-0.011	-5	0.763
MAPKAPK2	0.763	0.053	-3	0.771
MNK1	0.762	-0.036	-2	0.677
PKCI	0.762	-0.063	2	0.673
PKMYT1_TYR	0.762	0.004	3	0.799
LIMK2_TYR	0.761	0.038	-3	0.861
GCN2	0.760	-0.178	2	0.750
MARK2	0.760	-0.109	4	0.706
CK2A1	0.759	0.046	1	0.647
MAP2K7_TYR	0.759	-0.171	2	0.807
P70S6K	0.758	0.002	-3	0.740
PLK4	0.758	-0.169	2	0.594
MARK3	0.758	-0.075	4	0.741
MNK2	0.757	-0.059	-2	0.669
YANK3	0.757	-0.031	2	0.367
PINK1_TYR	0.757	-0.139	1	0.726
AKT3	0.757	0.061	-3	0.693
TXK	0.756	0.079	1	0.714
PKCT	0.756	-0.082	2	0.651
PRKX	0.756	0.106	-3	0.747
RIPK2	0.755	-0.322	1	0.553
ULK1	0.755	-0.248	-3	0.762
MARK1	0.755	-0.129	4	0.760
NUAK1	0.753	-0.061	-3	0.809
PKACA	0.753	0.028	-2	0.522
CAMK1A	0.752	-0.014	-3	0.702
EPHA6	0.752	-0.050	-1	0.858
ABL2	0.752	-0.007	-1	0.819
BCKDK	0.751	-0.216	-1	0.764
SIK	0.750	-0.053	-3	0.785
EPHB4	0.750	-0.068	-1	0.833
PHKG1	0.750	-0.086	-3	0.841
FGR	0.750	-0.040	1	0.705
YANK2	0.749	-0.041	2	0.377
FAM20C	0.748	0.045	2	0.608
YES1	0.748	-0.047	-1	0.859
ABL1	0.748	-0.023	-1	0.814
LCK	0.748	0.028	-1	0.852
LIMK1_TYR	0.747	-0.168	2	0.795
BLK	0.747	0.042	-1	0.853
RET	0.747	-0.192	1	0.640
MST1R	0.745	-0.164	3	0.750
CSF1R	0.744	-0.116	3	0.728
TYRO3	0.744	-0.171	3	0.733
EPHA4	0.744	-0.056	2	0.737
FER	0.743	-0.123	1	0.718
TNK2	0.743	-0.066	3	0.692
PAK6	0.743	-0.037	-2	0.592
INSRR	0.743	-0.102	3	0.672
FYN	0.743	0.042	-1	0.836
HCK	0.742	-0.076	-1	0.843
MAPKAPK5	0.742	-0.078	-3	0.740
SRMS	0.742	-0.081	1	0.696
PKN1	0.741	-0.042	-3	0.754
DDR1	0.741	-0.206	4	0.820
ROS1	0.741	-0.189	3	0.696
BRSK1	0.741	-0.069	-3	0.811
ITK	0.741	-0.068	-1	0.806
MET	0.741	-0.025	3	0.721
SNRK	0.740	-0.220	2	0.631
KIT	0.739	-0.105	3	0.733
JAK3	0.739	-0.153	1	0.634
TTBK1	0.738	-0.186	2	0.559
BMX	0.738	-0.039	-1	0.749
JAK2	0.738	-0.237	1	0.627
BRSK2	0.738	-0.133	-3	0.820
FGFR2	0.737	-0.131	3	0.729
TYK2	0.737	-0.324	1	0.622
KDR	0.737	-0.107	3	0.688
EPHB1	0.736	-0.138	1	0.678
SYK	0.736	0.113	-1	0.772
PTK2	0.735	0.060	-1	0.779
EPHB2	0.735	-0.104	-1	0.820
EPHB3	0.734	-0.142	-1	0.819
MERTK	0.734	-0.117	3	0.696
CK1G3	0.734	0.120	-3	0.491
WEE1_TYR	0.733	-0.078	-1	0.747
TEC	0.733	-0.080	-1	0.757
FLT1	0.733	-0.082	-1	0.815
NEK10_TYR	0.732	-0.165	1	0.560
FLT3	0.731	-0.194	3	0.737
TNK1	0.731	-0.157	3	0.715
PTK2B	0.730	-0.037	-1	0.800
PAK5	0.730	-0.066	-2	0.546
TEK	0.730	-0.157	3	0.661
SRC	0.729	-0.033	-1	0.831
MATK	0.729	-0.077	-1	0.750
CK1G1	0.729	0.083	-3	0.640
FGFR3	0.729	-0.112	3	0.700
PDGFRB	0.728	-0.265	3	0.738
ERBB2	0.728	-0.137	1	0.610
FGFR1	0.728	-0.188	3	0.682
AXL	0.728	-0.199	3	0.698
EPHA7	0.727	-0.125	2	0.732
FRK	0.727	-0.106	-1	0.854
LYN	0.727	-0.096	3	0.649
TNNI3K_TYR	0.726	-0.145	1	0.634
EPHA3	0.726	-0.151	2	0.705
BTK	0.726	-0.210	-1	0.774
PHKG2	0.726	-0.134	-3	0.807
JAK1	0.726	-0.175	1	0.556
DDR2	0.724	-0.102	3	0.661
PTK6	0.723	-0.230	-1	0.734
ALK	0.723	-0.204	3	0.636
LTK	0.723	-0.201	3	0.660
CK1G2	0.723	0.138	-3	0.571
ZAP70	0.722	0.083	-1	0.700
EPHA5	0.722	-0.113	2	0.720
EPHA8	0.722	-0.099	-1	0.807
EGFR	0.722	-0.088	1	0.533
NTRK1	0.720	-0.260	-1	0.805
INSR	0.720	-0.202	3	0.655
PAK4	0.720	-0.059	-2	0.551
FGFR4	0.720	-0.097	-1	0.769
CK1A	0.720	0.168	-3	0.532
NTRK3	0.719	-0.169	-1	0.763
PDGFRA	0.719	-0.320	3	0.735
EPHA1	0.717	-0.208	3	0.697
ERBB4	0.717	-0.029	1	0.557
CSK	0.716	-0.173	2	0.733
FLT4	0.716	-0.235	3	0.678
NTRK2	0.715	-0.282	3	0.679
PKG1	0.713	-0.056	-2	0.487
EPHA2	0.711	-0.118	-1	0.771
IGF1R	0.708	-0.167	3	0.592
MUSK	0.702	-0.195	1	0.530
FES	0.699	-0.134	-1	0.725