Motif 102 (n=173)
Position-wise Probabilities
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| uniprot | genes | site | source | protein | function |
|---|---|---|---|---|---|
| A2RRP1 | NBAS | S1384 | ochoa | NBAS subunit of NRZ tethering complex (Neuroblastoma-amplified gene protein) (Neuroblastoma-amplified sequence) | Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity). {ECO:0000250|UniProtKB:Q5TYW4, ECO:0000269|PubMed:19369418}. |
| A6NI28 | ARHGAP42 | S714 | ochoa | Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42) | May influence blood pressure by functioning as a GTPase-activating protein for RHOA in vascular smooth muscle. {ECO:0000269|PubMed:24335996}. |
| A6NKT7 | RGPD3 | S1305 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A6NKT7 | RGPD3 | S1535 | ochoa | RanBP2-like and GRIP domain-containing protein 3 | None |
| A7KAX9 | ARHGAP32 | S892 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A7KAX9 | ARHGAP32 | S952 | ochoa | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) | GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}. |
| A8K979 | ERI2 | S478 | ochoa | ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1) | None |
| H7C1W4 | None | S58 | ochoa | Uncharacterized protein | None |
| O14715 | RGPD8 | S1304 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O14715 | RGPD8 | S1534 | ochoa | RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3) | None |
| O15018 | PDZD2 | S1270 | ochoa | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] | None |
| O15350 | TP73 | S145 | ochoa | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}. |
| O15534 | PER1 | S704 | ochoa | Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui) | Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. |
| O43402 | EMC8 | S103 | ochoa | ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B) | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305}. |
| O43493 | TGOLN2 | S150 | ochoa | Trans-Golgi network integral membrane protein 2 (Trans-Golgi network glycoprotein 46) (TGN38 homolog) (hTGN46) (Trans-Golgi network glycoprotein 48) (hTGN48) (Trans-Golgi network glycoprotein 51) (hTGN51) (Trans-Golgi network protein 2) | May be involved in regulating membrane traffic to and from trans-Golgi network. |
| O43572 | AKAP10 | S278 | ochoa | A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10) | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}. |
| O60333 | KIF1B | S1659 | ochoa | Kinesin-like protein KIF1B (Klp) (EC 5.6.1.3) | Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules. {ECO:0000269|PubMed:16225668}.; FUNCTION: [Isoform 2]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells (By similarity). Functions as a downstream effector in a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells (PubMed:18334619). {ECO:0000250|UniProtKB:Q60575, ECO:0000269|PubMed:18334619}.; FUNCTION: [Isoform 3]: Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde transport of mitochondria. {ECO:0000269|PubMed:16225668}. |
| O60336 | MAPKBP1 | S1188 | ochoa | Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1) | Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6NS57, ECO:0000269|PubMed:22700971}. |
| O75151 | PHF2 | S625 | ochoa | Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2) | Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585). Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585). Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585). The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585). Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). {ECO:0000250|UniProtKB:Q9WTU0, ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}. |
| O75362 | ZNF217 | S848 | ochoa | Zinc finger protein 217 | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}. |
| O75940 | SMNDC1 | S201 | ochoa | Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1) | Involved in spliceosome assembly. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}. |
| O94761 | RECQL4 | S251 | ochoa|psp | ATP-dependent DNA helicase Q4 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ4) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4) | An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction (PubMed:28653661). Does not unwind more than 18 bp of dsDNA (PubMed:28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed:22730300). The core helicase domain binds ssDNA (PubMed:22730300, PubMed:28653661). {ECO:0000269|PubMed:15317757, ECO:0000269|PubMed:22730300, ECO:0000269|PubMed:28653661}. |
| O95049 | TJP3 | S654 | ochoa | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). {ECO:0000250|UniProtKB:O62683, ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:16129888, ECO:0000269|PubMed:21411630}. |
| O95600 | KLF8 | S48 | psp | Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741) | Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269|PubMed:10756197, ECO:0000269|PubMed:12820964, ECO:0000269|PubMed:16617055}. |
| O95835 | LATS1 | S613 | ochoa|psp | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437443, PubMed:28068668). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288, PubMed:26437443, PubMed:28068668). Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288, PubMed:26437443, PubMed:28068668). Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint (PubMed:15122335, PubMed:19927127). Negatively regulates G2/M transition by down-regulating CDK1 kinase activity (PubMed:9988268). Involved in the control of p53 expression (PubMed:15122335). Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1 (PubMed:15220930). May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:28068668, ECO:0000269|PubMed:39173637, ECO:0000269|PubMed:9988268}. |
| P04035 | HMGCR | S356 | ochoa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799). {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}. |
| P05023 | ATP1A1 | S694 | ochoa | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:29499166, ECO:0000269|PubMed:30388404}. |
| P05455 | SSB | S92 | ochoa | Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597). {ECO:0000269|PubMed:12384597, ECO:0000269|PubMed:2470590, ECO:0000269|PubMed:3192525}. |
| P08567 | PLEK | S57 | ochoa | Pleckstrin (Platelet 47 kDa protein) (p47) | Major protein kinase C substrate of platelets. |
| P0DJD0 | RGPD1 | S1289 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD0 | RGPD1 | S1519 | ochoa | RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6) | None |
| P0DJD1 | RGPD2 | S1297 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P0DJD1 | RGPD2 | S1527 | ochoa | RANBP2-like and GRIP domain-containing protein 2 (Ran-binding protein 2-like 2) (RanBP2-like 2) (RanBP2L2) | None |
| P10242 | MYB | S560 | ochoa | Transcriptional activator Myb (Proto-oncogene c-Myb) | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| P11171 | EPB41 | S712 | ochoa | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1) | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}. |
| P17947 | SPI1 | S140 | psp | Transcription factor PU.1 (31 kDa-transforming protein) | Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P17433, ECO:0000250|UniProtKB:Q6BDS1, ECO:0000269|PubMed:23658224, ECO:0000269|PubMed:33951726}. |
| P27816 | MAP4 | S384 | ochoa | Microtubule-associated protein 4 (MAP-4) | Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}. |
| P31629 | HIVEP2 | S412 | ochoa | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation. |
| P32519 | ELF1 | S376 | ochoa | ETS-related transcription factor Elf-1 (E74-like factor 1) | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}. |
| P35712 | SOX6 | S98 | ochoa | Transcription factor SOX-6 | Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). {ECO:0000250|UniProtKB:P40645, ECO:0000305|PubMed:32442410}. |
| P41208 | CETN2 | S20 | ochoa | Centrin-2 (Caltractin isoform 1) | Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; FUNCTION: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; FUNCTION: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; FUNCTION: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}. |
| P42685 | FRK | S37 | ochoa | Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}. |
| P43364 | MAGEA11 | S208 | ochoa|psp | Melanoma-associated antigen 11 (Cancer/testis antigen 1.11) (CT1.11) (MAGE-11 antigen) | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. {ECO:0000269|PubMed:15684378}. |
| P46527 | CDKN1B | S178 | ochoa|psp | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301, ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966, ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}. |
| P46821 | MAP1B | S2072 | ochoa | Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017, ECO:0000269|PubMed:33268592}. |
| P49792 | RANBP2 | S2510 | ochoa | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:22902403, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. |
| P78559 | MAP1A | S1264 | ochoa | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| P82094 | TMF1 | S77 | ochoa | TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) | Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269|PubMed:10428808, ECO:0000269|PubMed:1409643, ECO:0000269|PubMed:15467733, ECO:0000269|PubMed:17698061}. |
| Q01167 | FOXK2 | S170 | ochoa | Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1) | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex; recruits the PR-DUB complex to specific FOXK2-bound genes (PubMed:24634419, PubMed:30664650). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:30664650}. |
| Q02779 | MAP3K10 | S489 | ochoa | Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) | Activates the JUN N-terminal pathway. {ECO:0000250}. |
| Q03001 | DST | S2671 | ochoa | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). {ECO:0000250|UniProtKB:Q91ZU6}.; FUNCTION: [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; FUNCTION: [Isoform 6]: Required for bundling actin filaments around the nucleus. {ECO:0000250, ECO:0000269|PubMed:10428034, ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692}.; FUNCTION: [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Q03188 | CENPC | S73 | ochoa | Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Q10587 | TEF | S170 | ochoa | Thyrotroph embryonic factor | Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. |
| Q12830 | BPTF | S656 | ochoa | Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen) | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013). {ECO:0000269|PubMed:10575013, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:16728976, ECO:0000269|PubMed:16728978, ECO:0000269|PubMed:18042461, ECO:0000269|PubMed:28801535}. |
| Q12923 | PTPN13 | S273 | ochoa | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Q12955 | ANK3 | S3055 | ochoa | Ankyrin-3 (ANK-3) (Ankyrin-G) | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511, ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7836469}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}. |
| Q13023 | AKAP6 | S610 | ochoa | A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| Q13813 | SPTAN1 | S1190 | ochoa | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
| Q14139 | UBE4A | S1034 | ochoa | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. {ECO:0000250|UniProtKB:E9Q735, ECO:0000250|UniProtKB:P54860}. |
| Q14157 | UBAP2L | S398 | ochoa | Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L) | Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity). {ECO:0000250|UniProtKB:Q80X50, ECO:0000269|PubMed:29395067, ECO:0000269|PubMed:35633597}. |
| Q14674 | ESPL1 | S1153 | psp | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}. |
| Q14765 | STAT4 | S713 | ochoa|psp | Signal transducer and activator of transcription 4 | Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response (PubMed:10961885, PubMed:37256972, PubMed:8943379). Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma (PubMed:12213961, PubMed:35614130). Also participates in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (By similarity). After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated (PubMed:10415122, PubMed:7638186). Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes. Although IL12 appears to be the predominant activating signal, STAT4 can also be phosphorylated and activated in response to IFN-gamma stimulation via JAK1 and TYK2 and in response to different interleukins including IL23, IL2 and IL35 (PubMed:11114383, PubMed:34508746). Transcription activation of IFN-gamma gene is mediated by interaction with JUN that forms a complex that efficiently interacts with the AP-1-related sequence of the IFN-gamma promoter (By similarity). In response to IFN-alpha/beta signaling, acts as a transcriptional repressor and suppresses IL5 and IL13 mRNA expression during response to T-cell receptor (TCR) activation (PubMed:26990433). {ECO:0000250|UniProtKB:P42228, ECO:0000269|PubMed:10415122, ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12213961, ECO:0000269|PubMed:26990433, ECO:0000269|PubMed:34508746, ECO:0000269|PubMed:35614130, ECO:0000269|PubMed:37256972, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:8943379}. |
| Q15256 | PTPRR | S324 | ochoa | Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) | Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). {ECO:0000250}. |
| Q15561 | TEAD4 | S322 | psp | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}. |
| Q15652 | JMJD1C | S601 | ochoa | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). {ECO:0000250}. |
| Q16821 | PPP1R3A | S584 | ochoa | Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RG1) | Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). {ECO:0000250}. |
| Q16836 | HADH | S290 | ochoa | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity). {ECO:0000250|UniProtKB:Q61425, ECO:0000269|PubMed:10231530, ECO:0000269|PubMed:11489939, ECO:0000269|PubMed:16725361}. |
| Q1ED39 | KNOP1 | S238 | ochoa | Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein) | None |
| Q2M2Z5 | KIZ | S179 | ochoa | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. {ECO:0000269|PubMed:16980960}. |
| Q3L8U1 | CHD9 | S2861 | ochoa | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.-) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}. |
| Q4AC94 | C2CD3 | S2099 | ochoa | C2 domain-containing protein 3 | Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}. |
| Q4V9L6 | TMEM119 | S185 | ochoa | Transmembrane protein 119 (Osteoblast induction factor) (OBIF) | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}. |
| Q52LR7 | EPC2 | S754 | ochoa | Enhancer of polycomb homolog 2 (EPC-like) | May play a role in transcription or DNA repair. {ECO:0000250}. |
| Q5HYC2 | BRD10 | S1816 | ochoa | Uncharacterized bromodomain-containing protein 10 | None |
| Q5SVZ6 | ZMYM1 | S336 | ochoa | Zinc finger MYM-type protein 1 | None |
| Q5T1R4 | HIVEP3 | S2255 | ochoa | Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3) | Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Also binds to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and pro-inflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. {ECO:0000269|PubMed:11161801}. |
| Q5T5Y3 | CAMSAP1 | S862 | ochoa | Calmodulin-regulated spectrin-associated protein 1 | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24117850, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). {ECO:0000269|PubMed:19508979, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:24117850, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919}. |
| Q5TAX3 | TUT4 | S209 | ochoa | Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) | Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299, PubMed:31036859). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms (PubMed:25979828). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:25979828). Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (PubMed:25979828). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (PubMed:16643855). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:16643855, PubMed:18172165, PubMed:19703396, PubMed:25480299, PubMed:25979828). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (PubMed:30122351). {ECO:0000250|UniProtKB:B2RX14, ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:25979828, ECO:0000269|PubMed:30122351, ECO:0000269|PubMed:31036859}. |
| Q5THK1 | PRR14L | S1029 | ochoa | Protein PRR14L (Proline rich 14-like protein) | None |
| Q5U5R9 | HECTD2 | S78 | ochoa | Probable E3 ubiquitin-protein ligase HECTD2 (EC 2.3.2.26) (HECT domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECTD2) | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:28584101}.; FUNCTION: (Microbial infection) Catalyzes ubiquitination of Botulinum neurotoxin A light chain (LC) of C.botulinum neurotoxin type A (BoNT/A). {ECO:0000269|PubMed:28584101}. |
| Q5VT06 | CEP350 | S567 | ochoa | Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) | Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CPAP (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269|PubMed:15615782, ECO:0000269|PubMed:16314388, ECO:0000269|PubMed:17878239, ECO:0000269|PubMed:19052644, ECO:0000269|PubMed:28659385}. |
| Q5VWN6 | TASOR2 | S2009 | ochoa | Protein TASOR 2 | None |
| Q5W0Q7 | USPL1 | S1055 | ochoa | SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1) | SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}. |
| Q68DQ2 | CRYBG3 | S994 | ochoa | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}. |
| Q6P1L5 | FAM117B | S307 | ochoa | Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein) | None |
| Q6PGQ7 | BORA | S137 | ochoa|psp | Protein aurora borealis (HsBora) | Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}. |
| Q6T4R5 | NHS | S1499 | ochoa | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. {ECO:0000269|PubMed:20332100}. |
| Q6UWZ7 | ABRAXAS1 | S336 | ochoa | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17643121, ECO:0000269|PubMed:17643122, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:22357538, ECO:0000269|PubMed:26778126}. |
| Q6XZF7 | DNMBP | S1407 | ochoa | Dynamin-binding protein (Scaffold protein Tuba) | Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250|UniProtKB:E2RP94, ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620, ECO:0000269|PubMed:19767742, ECO:0000269|PubMed:20479467}. |
| Q765P7 | MTSS2 | S428 | ochoa | Protein MTSS 2 (Actin-bundling with BAIAP2 homology protein 1) (ABBA-1) (MTSS1-like protein) | Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106). {ECO:0000269|PubMed:14752106}. |
| Q7L8L6 | FASTKD5 | S95 | ochoa | FAST kinase domain-containing protein 5, mitochondrial | Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715). {ECO:0000269|PubMed:25683715}. |
| Q7Z3J3 | RGPD4 | S1305 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z3J3 | RGPD4 | S1535 | ochoa | RanBP2-like and GRIP domain-containing protein 4 | None |
| Q7Z699 | SPRED1 | S176 | ochoa | Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:18216281}. |
| Q7Z6Z7 | HUWE1 | S3555 | ochoa | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15567145, PubMed:15767685, PubMed:15989957, PubMed:17567951, PubMed:18488021, PubMed:19037095, PubMed:19713937, PubMed:20534529, PubMed:30217973). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Ubiquitination of MFN2 also takes place following induction of mitophagy; AMBRA1 acts as a cofactor for HUWE1-mediated ubiquitination (PubMed:30217973). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Mediates HAPSTR1 degradation, but is also a required cofactor in the pathway by which HAPSTR1 governs stress signaling (PubMed:35776542). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by mediating assembly of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains that are then recognized by TAB2: HUWE1 mediates branching of 'Lys-48'-linked chains of substrates initially modified with 'Lys-63'-linked conjugates by TRAF6 (PubMed:27746020). 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains protect 'Lys-63'-linkages from CYLD deubiquitination (PubMed:27746020). Ubiquitinates PPARA in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51593, ECO:0000250|UniProtKB:Q7TMY8, ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:20534529, ECO:0000269|PubMed:26214738, ECO:0000269|PubMed:27746020, ECO:0000269|PubMed:30217973, ECO:0000269|PubMed:35776542}. |
| Q7Z7G8 | VPS13B | S3052 | ochoa | Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B) | Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). {ECO:0000250|UniProtKB:Q07878, ECO:0000250|UniProtKB:Q80TY5, ECO:0000269|PubMed:21865173, ECO:0000269|PubMed:24334764, ECO:0000269|PubMed:26358774, ECO:0000269|PubMed:30962439, ECO:0000269|PubMed:32375900, ECO:0000269|PubMed:32560273, ECO:0000305|PubMed:25492866, ECO:0000305|PubMed:32560273}. |
| Q86UB2 | BIVM | S24 | ochoa | Basic immunoglobulin-like variable motif-containing protein | None |
| Q86UB9 | TMEM135 | S198 | ochoa | Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52) | Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. {ECO:0000250|UniProtKB:Q5U4F4, ECO:0000250|UniProtKB:Q9CYV5}. |
| Q86VP1 | TAX1BP1 | S508 | ochoa | Tax1-binding protein 1 (TRAF6-binding protein) | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:29940186, PubMed:30459273, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN-beta production (PubMed:21885437). Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). Mediates the autophagic degradation of other substrates including TICAM1 (PubMed:28898289). {ECO:0000269|PubMed:10435631, ECO:0000269|PubMed:10920205, ECO:0000269|PubMed:17703191, ECO:0000269|PubMed:21885437, ECO:0000269|PubMed:26451915, ECO:0000269|PubMed:27736772, ECO:0000269|PubMed:28898289, ECO:0000269|PubMed:29940186, ECO:0000269|PubMed:30459273, ECO:0000269|PubMed:30909570, ECO:0000269|PubMed:33226137, ECO:0000269|PubMed:34471133}. |
| Q86VQ1 | GLCCI1 | S258 | ochoa | Glucocorticoid-induced transcript 1 protein | None |
| Q86XL3 | ANKLE2 | S778 | ochoa | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216). Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216). May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666). It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216). Involved in brain development (PubMed:25259927). {ECO:0000269|PubMed:22770216, ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:31735666}. |
| Q8IVF2 | AHNAK2 | S1710 | ochoa | Protein AHNAK2 | None |
| Q8IVF2 | AHNAK2 | S4185 | ochoa | Protein AHNAK2 | None |
| Q8IVT5 | KSR1 | S238 | ochoa | Kinase suppressor of Ras 1 (EC 2.7.11.1) | Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. |
| Q8IY47 | KBTBD2 | S300 | ochoa | Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1) | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. {ECO:0000269|PubMed:27708159}. |
| Q8IYH5 | ZZZ3 | S391 | ochoa | ZZ-type zinc finger-containing protein 3 | Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed:30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:30217978}. |
| Q8IZQ8 | MYOCD | S347 | ochoa | Myocardin | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}. |
| Q8N122 | RPTOR | S696 | ochoa|psp | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:32561715, PubMed:37541260). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:32561715, PubMed:37541260). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:12747827, PubMed:24403073, PubMed:37541260). Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation (PubMed:12747827, PubMed:24403073, PubMed:26588989, PubMed:37541260). mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). {ECO:0000250|UniProtKB:Q8K4Q0, ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:24403073, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:32561715, ECO:0000269|PubMed:37541260}. |
| Q8N350 | CBARP | S200 | ochoa | Voltage-dependent calcium channel beta subunit-associated regulatory protein | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. {ECO:0000250|UniProtKB:Q66L44}. |
| Q8N3K9 | CMYA5 | S767 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8N3K9 | CMYA5 | S2452 | ochoa | Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76) | May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q70KF4}. |
| Q8NB14 | USP38 | S680 | ochoa | Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) | Deubiquitinating enzyme that plays a role in various cellular processes, including DNA repair, cell cycle regulation, and immune response (PubMed:22689415, PubMed:30497519, PubMed:31874856, PubMed:35238669). Plays a role in the inhibition of type I interferon signaling by mediating the 'Lys-33' to 'Lys-48' ubiquitination transition of TBK1 leading to its degradation (PubMed:27692986). Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome, thus maintaining LSD1 protein level in cells (PubMed:30497519). Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1 (PubMed:31874856). Mechanistically, removes the 'Lys-63'-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage (PubMed:31874856). Also acts as a specific deubiquitinase of histone deacetylase 3/HDAC3 and cleaves its 'Lys-63'-linked ubiquitin chains to lower its histone deacetylase activity (PubMed:32404892). Regulates MYC levels and cell proliferation via antagonizing ubiquitin E3 ligase FBXW7 thereby preventing MYC 'Lys-48'-linked ubiquitination and degradation (PubMed:34102342). Participates in antiviral response by removing both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of Zika virus envelope protein E (PubMed:34696459). Constitutively associated with IL-33R/IL1RL1, deconjugates its 'Lys-27'-linked polyubiquitination resulting in its autophagic degradation (PubMed:35238669). {ECO:0000269|PubMed:22689415, ECO:0000269|PubMed:27692986, ECO:0000269|PubMed:30497519, ECO:0000269|PubMed:31874856, ECO:0000269|PubMed:32404892, ECO:0000269|PubMed:34102342, ECO:0000269|PubMed:34696459, ECO:0000269|PubMed:35238669}. |
| Q8NCN2 | ZBTB34 | S164 | ochoa | Zinc finger and BTB domain-containing protein 34 | May be a transcriptional repressor. {ECO:0000269|PubMed:16718364}. |
| Q8NDX5 | PHC3 | S272 | ochoa | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:12167701}. |
| Q8NEL9 | DDHD1 | S790 | ochoa | Phospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase) | Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable) (PubMed:20359546, PubMed:22922100). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable) (PubMed:20359546). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology (PubMed:24599962). These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962). May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962). {ECO:0000250|UniProtKB:Q80YA3, ECO:0000269|PubMed:20359546, ECO:0000269|PubMed:22922100, ECO:0000269|PubMed:24599962, ECO:0000303|PubMed:24599962, ECO:0000305|PubMed:37189713}. |
| Q8NEV8 | EXPH5 | S948 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NEV8 | EXPH5 | S1733 | ochoa | Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b) | May act as Rab effector protein and play a role in vesicle trafficking. |
| Q8NEZ4 | KMT2C | S1947 | ochoa | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332). {ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:24081332, ECO:0000269|PubMed:25561738}. |
| Q8NG27 | PJA1 | S265 | ochoa | E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1) | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269|PubMed:12036302}. |
| Q8TC05 | MDM1 | S584 | ochoa | Nuclear protein MDM1 | Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}. |
| Q8WUY3 | PRUNE2 | S682 | ochoa | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269|PubMed:16288218}. |
| Q92833 | JARID2 | S331 | ochoa | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}. |
| Q93075 | TATDN2 | S115 | ochoa | 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2) | Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}. |
| Q96DT6 | ATG4C | S369 | ochoa | Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 3) (Autophagin-3) (Autophagy-related protein 4 homolog C) (HsAPG4C) | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:21177865, PubMed:29458288, PubMed:30661429). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (PubMed:21177865). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989). Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288). In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (PubMed:33773106). {ECO:0000250|UniProtKB:Q9Y4P1, ECO:0000269|PubMed:21177865, ECO:0000269|PubMed:29458288, ECO:0000269|PubMed:30661429, ECO:0000269|PubMed:33773106, ECO:0000269|PubMed:33909989}. |
| Q96F81 | DISP1 | S51 | ochoa | Protein dispatched homolog 1 | Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000250|UniProtKB:Q3TDN0, ECO:0000269|PubMed:22902404}. |
| Q96GX9 | APIP | S87 | ochoa|psp | Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP) | Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211, ECO:0000269|PubMed:24367089}. |
| Q96JQ2 | CLMN | S585 | ochoa | Calmin (Calponin-like transmembrane domain protein) | None |
| Q96L94 | SNX22 | S19 | ochoa | Sorting nexin-22 | May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:17400918). {ECO:0000250|UniProtKB:Q9D2Y5, ECO:0000269|PubMed:17400918}. |
| Q96M89 | CCDC138 | S154 | ochoa | Coiled-coil domain-containing protein 138 | None |
| Q96N64 | PWWP2A | S525 | ochoa | PWWP domain-containing protein 2A | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917). {ECO:0000250|UniProtKB:Q69Z61, ECO:0000269|PubMed:28645917, ECO:0000269|PubMed:30228260, ECO:0000269|PubMed:30327463}. |
| Q96RG2 | PASK | S843 | ochoa | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}. |
| Q96T37 | RBM15 | S765 | ochoa | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation (PubMed:26575292). Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing (PubMed:17001072, PubMed:19786495). High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing (PubMed:17001072, PubMed:19786495). May be implicated in HOX gene regulation (PubMed:11344311). {ECO:0000250|UniProtKB:Q0VBL3, ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:26575292, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:11344311}. |
| Q99666 | RGPD5 | S1304 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q99666 | RGPD5 | S1534 | ochoa | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | None |
| Q9BW91 | NUDT9 | S68 | ochoa | ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9) | Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. {ECO:0000269|PubMed:11385575}. |
| Q9BYX4 | IFIH1 | S301 | ochoa | Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:28594402, PubMed:32169843, PubMed:33727702). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. {ECO:0000269|PubMed:14645903, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19656871, ECO:0000269|PubMed:21217758, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:22160685, ECO:0000269|PubMed:28594402, ECO:0000269|PubMed:28606988, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:33440148, ECO:0000269|PubMed:33514628, ECO:0000269|PubMed:33727702}. |
| Q9C0A6 | SETD5 | S1198 | ochoa | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. {ECO:0000250|UniProtKB:Q5XJV7}. |
| Q9H0E3 | SAP130 | S875 | ochoa | Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}. |
| Q9H6K1 | ILRUN | S215 | ochoa|psp | Protein ILRUN (Inflammation and lipid regulator with UBA-like and NBR1-like domains protein) | Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}. |
| Q9H7U1 | CCSER2 | S328 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H7U1 | CCSER2 | S342 | ochoa | Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Protein GCAP14 homolog) | Microtubule-binding protein which might play a role in microtubule bundling. {ECO:0000250|UniProtKB:Q3UHI0}. |
| Q9H8K7 | PAAT | S177 | ochoa | ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT) | ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848). {ECO:0000269|PubMed:25063848}. |
| Q9HAU0 | PLEKHA5 | S526 | ochoa | Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2) | None |
| Q9HBD1 | RC3H2 | S837 | ochoa | Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2) | Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression (PubMed:25697406). Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains (PubMed:26489670). Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains (PubMed:26489670). Involved in the ubiquitination of MAP3K5 (PubMed:24448648, PubMed:26489670, PubMed:29186683). Able to interact with double-stranded RNA (dsRNA) (PubMed:26489670). {ECO:0000250|UniProtKB:P0C090, ECO:0000269|PubMed:24448648, ECO:0000269|PubMed:26489670, ECO:0000269|PubMed:29186683}. |
| Q9HCH0 | NCKAP5L | S767 | psp | Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169) | Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}. |
| Q9HCH5 | SYTL2 | S154 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCH5 | SYTL2 | S301 | ochoa | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. |
| Q9HCM1 | RESF1 | S1208 | ochoa | Retroelement silencing factor 1 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}. |
| Q9NR48 | ASH1L | S1791 | ochoa | Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H) | Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). {ECO:0000250|UniProtKB:Q99MY8, ECO:0000269|PubMed:21239497}. |
| Q9NVC3 | SLC38A7 | S28 | ochoa | Sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7) | Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation (PubMed:28416685, PubMed:35561222). The transport activity requires an acidic lysosomal lumen (PubMed:28416685). {ECO:0000269|PubMed:28416685, ECO:0000269|PubMed:35561222}. |
| Q9NVP2 | ASF1B | S20 | ochoa | Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II) | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904). {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:26527279}. |
| Q9NVV0 | TMEM38B | S262 | ochoa | Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Transmembrane protein 38B) | Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Activated by increased cytosolic Ca(2+) levels (By similarity). {ECO:0000250|UniProtKB:Q6GN30}. |
| Q9P227 | ARHGAP23 | S1412 | ochoa | Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23) | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}. |
| Q9P2Q2 | FRMD4A | S604 | ochoa | FERM domain-containing protein 4A | Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). {ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Q9UH73 | EBF1 | S567 | ochoa | Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor) | Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). {ECO:0000250|UniProtKB:Q07802, ECO:0000269|PubMed:27807034}.; FUNCTION: (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461). In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314). {ECO:0000269|PubMed:26819314, ECO:0000269|PubMed:28968461}. |
| Q9UHF7 | TRPS1 | S157 | ochoa | Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79) | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:17391059}. |
| Q9UI12 | ATP6V1H | S367 | ochoa | V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) | Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (PubMed:12032142). {ECO:0000250|UniProtKB:O46563, ECO:0000250|UniProtKB:P41807, ECO:0000269|PubMed:12032142, ECO:0000269|PubMed:33065002}. |
| Q9UIF8 | BAZ2B | S1680 | ochoa | Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) | Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (PubMed:28801535). Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000269|PubMed:28801535, ECO:0000303|PubMed:10662543}. |
| Q9UKK3 | PARP4 | S1048 | ochoa | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Q9UKL3 | CASP8AP2 | S1368 | ochoa | CASP8-associated protein 2 (FLICE-associated huge protein) | Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}. |
| Q9ULH0 | KIDINS220 | S1471 | ochoa | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269|PubMed:18089783}. |
| Q9ULM0 | PLEKHH1 | S522 | ochoa | Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) | None |
| Q9UMR3 | TBX20 | S312 | ochoa | T-box transcription factor TBX20 (T-box protein 20) | Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. {ECO:0000250}. |
| Q9UNA4 | POLI | S502 | ochoa | DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B) | Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543}. |
| Q9UPP1 | PHF8 | S175 | ochoa | Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8) | Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. {ECO:0000269|PubMed:19843542, ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20101266, ECO:0000269|PubMed:20208542, ECO:0000269|PubMed:20346720, ECO:0000269|PubMed:20421419, ECO:0000269|PubMed:20531378, ECO:0000269|PubMed:20548336, ECO:0000269|PubMed:20622853, ECO:0000269|PubMed:20622854, ECO:0000269|PubMed:31691806}. |
| Q9UPU5 | USP24 | S1943 | ochoa | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPU5 | USP24 | S2047 | ochoa|psp | Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) | Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}. |
| Q9UPW5 | AGTPBP1 | S1168 | ochoa | Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1) | Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). {ECO:0000269|PubMed:22170066, ECO:0000269|PubMed:24022482, ECO:0000269|PubMed:29593216, ECO:0000269|PubMed:30420557}. |
| Q9UQF2 | MAPK8IP1 | S197 | psp | C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1) | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. {ECO:0000250|UniProtKB:Q9WVI9}. |
| Q9Y2I9 | TBC1D30 | S800 | ochoa | TBC1 domain family member 30 | May act as a GTPase-activating protein for Rab family protein(s). {ECO:0000305}. |
| R4GMW8 | BIVM-ERCC5 | S24 | ochoa | DNA excision repair protein ERCC-5 | None |
| O15264 | MAPK13 | S27 | Sugiyama | Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212, ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148, ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666, ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}. |
| O14773 | TPP1 | Y449 | Sugiyama | Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) | Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:11054422, PubMed:19038966, PubMed:19038967). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (PubMed:11054422, PubMed:19038966, PubMed:19038967). Requires substrates with an unsubstituted N-terminus (PubMed:19038966). {ECO:0000269|PubMed:11054422, ECO:0000269|PubMed:19038966, ECO:0000269|PubMed:19038967}. |
Download
| reactome_id | name | p | -log10_p |
|---|---|---|---|
| R-HSA-8877627 | Vitamin E transport | 0.022717 | 1.644 |
| R-HSA-9636467 | Blockage of phagosome acidification | 0.022717 | 1.644 |
| R-HSA-8951671 | RUNX3 regulates YAP1-mediated transcription | 0.004968 | 2.304 |
| R-HSA-182218 | Nef Mediated CD8 Down-regulation | 0.087832 | 1.056 |
| R-HSA-8849470 | PTK6 Regulates Cell Cycle | 0.087832 | 1.056 |
| R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants | 0.098257 | 1.008 |
| R-HSA-170984 | ARMS-mediated activation | 0.128826 | 0.890 |
| R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | 0.148631 | 0.828 |
| R-HSA-9931512 | Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters | 0.158365 | 0.800 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 0.055878 | 1.253 |
| R-HSA-9661069 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) | 0.177501 | 0.751 |
| R-HSA-5656121 | Translesion synthesis by POLI | 0.205398 | 0.687 |
| R-HSA-174437 | Removal of the Flap Intermediate from the C-strand | 0.223471 | 0.651 |
| R-HSA-174414 | Processive synthesis on the C-strand of the telomere | 0.315804 | 0.501 |
| R-HSA-171306 | Packaging Of Telomere Ends | 0.315804 | 0.501 |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC... | 0.339032 | 0.470 |
| R-HSA-1855196 | IP3 and IP4 transport between cytosol and nucleus | 0.346600 | 0.460 |
| R-HSA-1855229 | IP6 and IP7 transport between cytosol and nucleus | 0.346600 | 0.460 |
| R-HSA-1855170 | IPs transport between nucleus and cytosol | 0.361476 | 0.442 |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | 0.361476 | 0.442 |
| R-HSA-5696394 | DNA Damage Recognition in GG-NER | 0.368788 | 0.433 |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | 0.368788 | 0.433 |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 0.383162 | 0.417 |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | 0.410941 | 0.386 |
| R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory si... | 0.293698 | 0.532 |
| R-HSA-141424 | Amplification of signal from the kinetochores | 0.293698 | 0.532 |
| R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts | 0.417689 | 0.379 |
| R-HSA-774815 | Nucleosome assembly | 0.456593 | 0.340 |
| R-HSA-606279 | Deposition of new CENPA-containing nucleosomes at the centromere | 0.456593 | 0.340 |
| R-HSA-1989781 | PPARA activates gene expression | 0.319924 | 0.495 |
| R-HSA-400206 | Regulation of lipid metabolism by PPARalpha | 0.326177 | 0.487 |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | 0.314780 | 0.502 |
| R-HSA-9656223 | Signaling by RAF1 mutants | 0.430956 | 0.366 |
| R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 0.450294 | 0.347 |
| R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 0.430956 | 0.366 |
| R-HSA-171319 | Telomere Extension By Telomerase | 0.323636 | 0.490 |
| R-HSA-9796292 | Formation of axial mesoderm | 0.016693 | 1.777 |
| R-HSA-9931521 | The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CL... | 0.024726 | 1.607 |
| R-HSA-77285 | Beta oxidation of myristoyl-CoA to lauroyl-CoA | 0.167988 | 0.775 |
| R-HSA-9931530 | Phosphorylation and nuclear translocation of the CRY:PER:kinase complex | 0.167988 | 0.775 |
| R-HSA-77305 | Beta oxidation of palmitoyl-CoA to myristoyl-CoA | 0.167988 | 0.775 |
| R-HSA-174430 | Telomere C-strand synthesis initiation | 0.196205 | 0.707 |
| R-HSA-3928663 | EPHA-mediated growth cone collapse | 0.315804 | 0.501 |
| R-HSA-9670095 | Inhibition of DNA recombination at telomere | 0.417689 | 0.379 |
| R-HSA-9639288 | Amino acids regulate mTORC1 | 0.155885 | 0.807 |
| R-HSA-174411 | Polymerase switching on the C-strand of the telomere | 0.299869 | 0.523 |
| R-HSA-5673000 | RAF activation | 0.376016 | 0.425 |
| R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants | 0.397211 | 0.401 |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | 0.285238 | 0.545 |
| R-HSA-5674135 | MAP2K and MAPK activation | 0.430956 | 0.366 |
| R-HSA-6802957 | Oncogenic MAPK signaling | 0.289470 | 0.538 |
| R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling | 0.068215 | 1.166 |
| R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling | 0.077287 | 1.112 |
| R-HSA-167590 | Nef Mediated CD4 Down-regulation | 0.108564 | 0.964 |
| R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 0.004458 | 2.351 |
| R-HSA-5696395 | Formation of Incision Complex in GG-NER | 0.417689 | 0.379 |
| R-HSA-2995383 | Initiation of Nuclear Envelope (NE) Reformation | 0.266884 | 0.574 |
| R-HSA-69618 | Mitotic Spindle Checkpoint | 0.364714 | 0.438 |
| R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta | 0.339890 | 0.469 |
| R-HSA-918233 | TRAF3-dependent IRF activation pathway | 0.214486 | 0.669 |
| R-HSA-933541 | TRAF6 mediated IRF7 activation | 0.397211 | 0.401 |
| R-HSA-77286 | mitochondrial fatty acid beta-oxidation of saturated fatty acids | 0.124624 | 0.904 |
| R-HSA-8939245 | RUNX1 regulates transcription of genes involved in BCR signaling | 0.077287 | 1.112 |
| R-HSA-77310 | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA | 0.018576 | 1.731 |
| R-HSA-77348 | Beta oxidation of octanoyl-CoA to hexanoyl-CoA | 0.018576 | 1.731 |
| R-HSA-77350 | Beta oxidation of hexanoyl-CoA to butanoyl-CoA | 0.018576 | 1.731 |
| R-HSA-446107 | Type I hemidesmosome assembly | 0.118753 | 0.925 |
| R-HSA-5658623 | FGFRL1 modulation of FGFR1 signaling | 0.148631 | 0.828 |
| R-HSA-9659787 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects | 0.177501 | 0.751 |
| R-HSA-73980 | RNA Polymerase III Transcription Termination | 0.232353 | 0.634 |
| R-HSA-933542 | TRAF6 mediated NF-kB activation | 0.291764 | 0.535 |
| R-HSA-212300 | PRC2 methylates histones and DNA | 0.390227 | 0.409 |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | 0.397211 | 0.401 |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | 0.456593 | 0.340 |
| R-HSA-6807878 | COPI-mediated anterograde transport | 0.348201 | 0.458 |
| R-HSA-2467813 | Separation of Sister Chromatids | 0.348052 | 0.458 |
| R-HSA-69231 | Cyclin D associated events in G1 | 0.450294 | 0.347 |
| R-HSA-69236 | G1 Phase | 0.450294 | 0.347 |
| R-HSA-2032785 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | 0.018576 | 1.731 |
| R-HSA-5656169 | Termination of translesion DNA synthesis | 0.331378 | 0.480 |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | 0.267862 | 0.572 |
| R-HSA-9020933 | Interleukin-23 signaling | 0.118753 | 0.925 |
| R-HSA-139915 | Activation of PUMA and translocation to mitochondria | 0.108564 | 0.964 |
| R-HSA-77346 | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA | 0.024726 | 1.607 |
| R-HSA-9020958 | Interleukin-21 signaling | 0.128826 | 0.890 |
| R-HSA-164938 | Nef-mediates down modulation of cell surface receptors by recruiting them to cla... | 0.223471 | 0.651 |
| R-HSA-5620922 | BBSome-mediated cargo-targeting to cilium | 0.249816 | 0.602 |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | 0.368788 | 0.433 |
| R-HSA-77289 | Mitochondrial Fatty Acid Beta-Oxidation | 0.339890 | 0.469 |
| R-HSA-8984722 | Interleukin-35 Signalling | 0.167988 | 0.775 |
| R-HSA-165159 | MTOR signalling | 0.437476 | 0.359 |
| R-HSA-77288 | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids | 0.214486 | 0.669 |
| R-HSA-77387 | Insulin receptor recycling | 0.323636 | 0.490 |
| R-HSA-9687139 | Aberrant regulation of mitotic cell cycle due to RB1 defects | 0.339032 | 0.470 |
| R-HSA-9932298 | Degradation of CRY and PER proteins | 0.430956 | 0.366 |
| R-HSA-68877 | Mitotic Prometaphase | 0.440305 | 0.356 |
| R-HSA-169893 | Prolonged ERK activation events | 0.205398 | 0.687 |
| R-HSA-2299718 | Condensation of Prophase Chromosomes | 0.024937 | 1.603 |
| R-HSA-2028269 | Signaling by Hippo | 0.223471 | 0.651 |
| R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis | 0.283565 | 0.547 |
| R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands | 0.186907 | 0.728 |
| R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK | 0.339032 | 0.470 |
| R-HSA-180746 | Nuclear import of Rev protein | 0.376016 | 0.425 |
| R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic | 0.348201 | 0.458 |
| R-HSA-8943724 | Regulation of PTEN gene transcription | 0.184307 | 0.734 |
| R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation | 0.126353 | 0.898 |
| R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 0.047651 | 1.322 |
| R-HSA-9820865 | Z-decay: degradation of maternal mRNAs by zygotically expressed factors | 0.167988 | 0.775 |
| R-HSA-9837092 | FASTK family proteins regulate processing and stability of mitochondrial RNAs | 0.196205 | 0.707 |
| R-HSA-77352 | Beta oxidation of butanoyl-CoA to acetyl-CoA | 0.196205 | 0.707 |
| R-HSA-166208 | mTORC1-mediated signalling | 0.275272 | 0.560 |
| R-HSA-429947 | Deadenylation of mRNA | 0.291764 | 0.535 |
| R-HSA-177243 | Interactions of Rev with host cellular proteins | 0.417689 | 0.379 |
| R-HSA-176033 | Interactions of Vpr with host cellular proteins | 0.417689 | 0.379 |
| R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templa... | 0.424360 | 0.372 |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | 0.424360 | 0.372 |
| R-HSA-68882 | Mitotic Anaphase | 0.287923 | 0.541 |
| R-HSA-2555396 | Mitotic Metaphase and Anaphase | 0.290477 | 0.537 |
| R-HSA-5675221 | Negative regulation of MAPK pathway | 0.430956 | 0.366 |
| R-HSA-3214841 | PKMTs methylate histone lysines | 0.105975 | 0.975 |
| R-HSA-9733709 | Cardiogenesis | 0.010633 | 1.973 |
| R-HSA-9909649 | Regulation of PD-L1(CD274) transcription | 0.054493 | 1.264 |
| R-HSA-110331 | Cleavage of the damaged purine | 0.397211 | 0.401 |
| R-HSA-187687 | Signalling to ERKs | 0.084748 | 1.072 |
| R-HSA-68886 | M Phase | 0.095011 | 1.022 |
| R-HSA-9768727 | Regulation of CDH1 posttranslational processing and trafficking to plasma membra... | 0.077997 | 1.108 |
| R-HSA-73927 | Depurination | 0.404115 | 0.393 |
| R-HSA-9909396 | Circadian clock | 0.092335 | 1.035 |
| R-HSA-8878171 | Transcriptional regulation by RUNX1 | 0.008031 | 2.095 |
| R-HSA-1640170 | Cell Cycle | 0.135857 | 0.867 |
| R-HSA-111458 | Formation of apoptosome | 0.138785 | 0.858 |
| R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors | 0.177501 | 0.751 |
| R-HSA-171007 | p38MAPK events | 0.196205 | 0.707 |
| R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.354081 | 0.451 |
| R-HSA-9675126 | Diseases of mitotic cell cycle | 0.354081 | 0.451 |
| R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not kno... | 0.361476 | 0.442 |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | 0.404115 | 0.393 |
| R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | 0.405258 | 0.392 |
| R-HSA-5617833 | Cilium Assembly | 0.431263 | 0.365 |
| R-HSA-917977 | Transferrin endocytosis and recycling | 0.383162 | 0.417 |
| R-HSA-3214842 | HDMs demethylate histones | 0.050040 | 1.301 |
| R-HSA-9627069 | Regulation of the apoptosome activity | 0.138785 | 0.858 |
| R-HSA-111461 | Cytochrome c-mediated apoptotic response | 0.158365 | 0.800 |
| R-HSA-9909505 | Modulation of host responses by IFN-stimulated genes | 0.223471 | 0.651 |
| R-HSA-9634638 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling | 0.283565 | 0.547 |
| R-HSA-5689901 | Metalloprotease DUBs | 0.307882 | 0.512 |
| R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 0.192563 | 0.715 |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | 0.410941 | 0.386 |
| R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | 0.315804 | 0.501 |
| R-HSA-69278 | Cell Cycle, Mitotic | 0.140549 | 0.852 |
| R-HSA-9857377 | Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autopha... | 0.041736 | 1.379 |
| R-HSA-9843745 | Adipogenesis | 0.239448 | 0.621 |
| R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network | 0.132291 | 0.878 |
| R-HSA-68875 | Mitotic Prophase | 0.069896 | 1.156 |
| R-HSA-1237112 | Methionine salvage pathway | 0.241134 | 0.618 |
| R-HSA-9772755 | Formation of WDR5-containing histone-modifying complexes | 0.084748 | 1.072 |
| R-HSA-9834899 | Specification of the neural plate border | 0.241134 | 0.618 |
| R-HSA-69620 | Cell Cycle Checkpoints | 0.396475 | 0.402 |
| R-HSA-9945266 | Differentiation of T cells | 0.205398 | 0.687 |
| R-HSA-9942503 | Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) | 0.205398 | 0.687 |
| R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic | 0.245131 | 0.611 |
| R-HSA-9819196 | Zygotic genome activation (ZGA) | 0.003511 | 2.455 |
| R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases | 0.205398 | 0.687 |
| R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 0.205398 | 0.687 |
| R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 0.185401 | 0.732 |
| R-HSA-9931510 | Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock gene... | 0.006226 | 2.206 |
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | 0.167988 | 0.775 |
| R-HSA-9683610 | Maturation of nucleoprotein | 0.177501 | 0.751 |
| R-HSA-9933387 | RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression | 0.339032 | 0.470 |
| R-HSA-6807070 | PTEN Regulation | 0.267021 | 0.573 |
| R-HSA-9018519 | Estrogen-dependent gene expression | 0.257782 | 0.589 |
| R-HSA-3247509 | Chromatin modifying enzymes | 0.074308 | 1.129 |
| R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specif... | 0.275272 | 0.560 |
| R-HSA-114452 | Activation of BH3-only proteins | 0.339032 | 0.470 |
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | 0.128826 | 0.890 |
| R-HSA-167044 | Signalling to RAS | 0.258399 | 0.588 |
| R-HSA-9836573 | Mitochondrial RNA degradation | 0.291764 | 0.535 |
| R-HSA-9931509 | Expression of BMAL (ARNTL), CLOCK, and NPAS2 | 0.410941 | 0.386 |
| R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | 0.049319 | 1.307 |
| R-HSA-5688426 | Deubiquitination | 0.388722 | 0.410 |
| R-HSA-2559583 | Cellular Senescence | 0.400775 | 0.397 |
| R-HSA-4839726 | Chromatin organization | 0.091584 | 1.038 |
| R-HSA-1482798 | Acyl chain remodeling of CL | 0.186907 | 0.728 |
| R-HSA-9833109 | Evasion by RSV of host interferon responses | 0.346600 | 0.460 |
| R-HSA-8939211 | ESR-mediated signaling | 0.342049 | 0.466 |
| R-HSA-373753 | Nephrin family interactions | 0.249816 | 0.602 |
| R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) | 0.079711 | 1.098 |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | 0.390227 | 0.409 |
| R-HSA-9619665 | EGR2 and SOX10-mediated initiation of Schwann cell myelination | 0.077997 | 1.108 |
| R-HSA-9833110 | RSV-host interactions | 0.385129 | 0.414 |
| R-HSA-373760 | L1CAM interactions | 0.440671 | 0.356 |
| R-HSA-9008059 | Interleukin-37 signaling | 0.065052 | 1.187 |
| R-HSA-111471 | Apoptotic factor-mediated response | 0.232353 | 0.634 |
| R-HSA-9694631 | Maturation of nucleoprotein | 0.241134 | 0.618 |
| R-HSA-5689896 | Ovarian tumor domain proteases | 0.397211 | 0.401 |
| R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex | 0.397211 | 0.401 |
| R-HSA-9909648 | Regulation of PD-L1(CD274) expression | 0.376070 | 0.425 |
| R-HSA-3214847 | HATs acetylate histones | 0.360600 | 0.443 |
| R-HSA-9816359 | Maternal to zygotic transition (MZT) | 0.209457 | 0.679 |
| R-HSA-8878159 | Transcriptional regulation by RUNX3 | 0.352343 | 0.453 |
| R-HSA-109606 | Intrinsic Pathway for Apoptosis | 0.167965 | 0.775 |
| R-HSA-1660499 | Synthesis of PIPs at the plasma membrane | 0.192563 | 0.715 |
| R-HSA-9637687 | Suppression of phagosomal maturation | 0.307882 | 0.512 |
| R-HSA-2393930 | Phosphate bond hydrolysis by NUDT proteins | 0.376016 | 0.425 |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | 0.283565 | 0.547 |
| R-HSA-168638 | NOD1/2 Signaling Pathway | 0.376016 | 0.425 |
| R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian expression | 0.376016 | 0.425 |
| R-HSA-9764265 | Regulation of CDH1 Expression and Function | 0.379170 | 0.421 |
| R-HSA-9764274 | Regulation of Expression and Function of Type I Classical Cadherins | 0.379170 | 0.421 |
| R-HSA-8854691 | Interleukin-20 family signaling | 0.283565 | 0.547 |
| R-HSA-110329 | Cleavage of the damaged pyrimidine | 0.437476 | 0.359 |
| R-HSA-446728 | Cell junction organization | 0.447652 | 0.349 |
| R-HSA-73928 | Depyrimidination | 0.437476 | 0.359 |
| R-HSA-1500931 | Cell-Cell communication | 0.343567 | 0.464 |
| R-HSA-9758941 | Gastrulation | 0.301182 | 0.521 |
| R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected ... | 0.376016 | 0.425 |
| R-HSA-9607240 | FLT3 Signaling | 0.105975 | 0.975 |
| R-HSA-9617828 | FOXO-mediated transcription of cell cycle genes | 0.039096 | 1.408 |
| R-HSA-191273 | Cholesterol biosynthesis | 0.259819 | 0.585 |
| R-HSA-9824585 | Regulation of MITF-M-dependent genes involved in pigmentation | 0.456593 | 0.340 |
| R-HSA-381038 | XBP1(S) activates chaperone genes | 0.024702 | 1.607 |
| R-HSA-74158 | RNA Polymerase III Transcription | 0.390227 | 0.409 |
| R-HSA-9759476 | Regulation of Homotypic Cell-Cell Adhesion | 0.449292 | 0.347 |
| R-HSA-381070 | IRE1alpha activates chaperones | 0.029959 | 1.523 |
| R-HSA-109581 | Apoptosis | 0.341806 | 0.466 |
| R-HSA-451927 | Interleukin-2 family signaling | 0.417689 | 0.379 |
| R-HSA-9637690 | Response of Mtb to phagocytosis | 0.443921 | 0.353 |
| R-HSA-8953750 | Transcriptional Regulation by E2F6 | 0.410941 | 0.386 |
| R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 0.361476 | 0.442 |
| R-HSA-9683701 | Translation of Structural Proteins | 0.430956 | 0.366 |
| R-HSA-9856651 | MITF-M-dependent gene expression | 0.304303 | 0.517 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 0.354081 | 0.451 |
| R-HSA-1483255 | PI Metabolism | 0.372912 | 0.428 |
| R-HSA-381119 | Unfolded Protein Response (UPR) | 0.106518 | 0.973 |
| R-HSA-9614085 | FOXO-mediated transcription | 0.360600 | 0.443 |
| R-HSA-73886 | Chromosome Maintenance | 0.459844 | 0.337 |
| R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 0.459844 | 0.337 |
| R-HSA-3371556 | Cellular response to heat stress | 0.459844 | 0.337 |
| R-HSA-389948 | Co-inhibition by PD-1 | 0.461185 | 0.336 |
| R-HSA-72165 | mRNA Splicing - Minor Pathway | 0.462821 | 0.335 |
| R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF | 0.462821 | 0.335 |
| R-HSA-9649948 | Signaling downstream of RAS mutants | 0.462821 | 0.335 |
| R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants | 0.462821 | 0.335 |
| R-HSA-6802949 | Signaling by RAS mutants | 0.462821 | 0.335 |
| R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus | 0.462821 | 0.335 |
| R-HSA-5357905 | Regulation of TNFR1 signaling | 0.462821 | 0.335 |
| R-HSA-75153 | Apoptotic execution phase | 0.462821 | 0.335 |
| R-HSA-3928665 | EPH-ephrin mediated repulsion of cells | 0.468978 | 0.329 |
| R-HSA-8955332 | Carboxyterminal post-translational modifications of tubulin | 0.468978 | 0.329 |
| R-HSA-162909 | Host Interactions of HIV factors | 0.471164 | 0.327 |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 0.475064 | 0.323 |
| R-HSA-5357801 | Programmed Cell Death | 0.478815 | 0.320 |
| R-HSA-73893 | DNA Damage Bypass | 0.481082 | 0.318 |
| R-HSA-69563 | p53-Dependent G1 DNA Damage Response | 0.481082 | 0.318 |
| R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint | 0.481082 | 0.318 |
| R-HSA-5658442 | Regulation of RAS by GAPs | 0.487030 | 0.312 |
| R-HSA-187037 | Signaling by NTRK1 (TRKA) | 0.489714 | 0.310 |
| R-HSA-1257604 | PIP3 activates AKT signaling | 0.490086 | 0.310 |
| R-HSA-1483257 | Phospholipid metabolism | 0.490086 | 0.310 |
| R-HSA-3371571 | HSF1-dependent transactivation | 0.492911 | 0.307 |
| R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 0.496022 | 0.304 |
| R-HSA-1266738 | Developmental Biology | 0.498453 | 0.302 |
| R-HSA-6794361 | Neurexins and neuroligins | 0.498725 | 0.302 |
| R-HSA-9692916 | SARS-CoV-1 activates/modulates innate immune responses | 0.498725 | 0.302 |
| R-HSA-9730414 | MITF-M-regulated melanocyte development | 0.501898 | 0.299 |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 0.504472 | 0.297 |
| R-HSA-1221632 | Meiotic synapsis | 0.504472 | 0.297 |
| R-HSA-8948751 | Regulation of PTEN stability and activity | 0.504472 | 0.297 |
| R-HSA-8856688 | Golgi-to-ER retrograde transport | 0.507853 | 0.294 |
| R-HSA-73929 | Base-Excision Repair, AP Site Formation | 0.510154 | 0.292 |
| R-HSA-418990 | Adherens junctions interactions | 0.516061 | 0.287 |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | 0.521324 | 0.283 |
| R-HSA-5578775 | Ion homeostasis | 0.521324 | 0.283 |
| R-HSA-75893 | TNF signaling | 0.521324 | 0.283 |
| R-HSA-5654736 | Signaling by FGFR1 | 0.521324 | 0.283 |
| R-HSA-2980766 | Nuclear Envelope Breakdown | 0.526814 | 0.278 |
| R-HSA-1483166 | Synthesis of PA | 0.526814 | 0.278 |
| R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 0.526814 | 0.278 |
| R-HSA-9820952 | Respiratory Syncytial Virus Infection Pathway | 0.529062 | 0.276 |
| R-HSA-180786 | Extension of Telomeres | 0.537606 | 0.270 |
| R-HSA-191859 | snRNP Assembly | 0.537606 | 0.270 |
| R-HSA-194441 | Metabolism of non-coding RNA | 0.537606 | 0.270 |
| R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at... | 0.537606 | 0.270 |
| R-HSA-429914 | Deadenylation-dependent mRNA decay | 0.537606 | 0.270 |
| R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures | 0.537606 | 0.270 |
| R-HSA-1632852 | Macroautophagy | 0.542855 | 0.265 |
| R-HSA-983189 | Kinesins | 0.542910 | 0.265 |
| R-HSA-9764725 | Negative Regulation of CDH1 Gene Transcription | 0.542910 | 0.265 |
| R-HSA-168325 | Viral Messenger RNA Synthesis | 0.548153 | 0.261 |
| R-HSA-8939902 | Regulation of RUNX2 expression and activity | 0.548153 | 0.261 |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | 0.549647 | 0.260 |
| R-HSA-1852241 | Organelle biogenesis and maintenance | 0.549908 | 0.260 |
| R-HSA-375165 | NCAM signaling for neurite out-growth | 0.553337 | 0.257 |
| R-HSA-6784531 | tRNA processing in the nucleus | 0.553337 | 0.257 |
| R-HSA-9707616 | Heme signaling | 0.553337 | 0.257 |
| R-HSA-212165 | Epigenetic regulation of gene expression | 0.556843 | 0.254 |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centr... | 0.558461 | 0.253 |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | 0.558461 | 0.253 |
| R-HSA-69615 | G1/S DNA Damage Checkpoints | 0.558461 | 0.253 |
| R-HSA-8848021 | Signaling by PTK6 | 0.558461 | 0.253 |
| R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases | 0.558461 | 0.253 |
| R-HSA-8957322 | Metabolism of steroids | 0.559142 | 0.252 |
| R-HSA-936837 | Ion transport by P-type ATPases | 0.563527 | 0.249 |
| R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signali... | 0.563527 | 0.249 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 0.566316 | 0.247 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulati... | 0.568536 | 0.245 |
| R-HSA-6802952 | Signaling by BRAF and RAF1 fusions | 0.568536 | 0.245 |
| R-HSA-166520 | Signaling by NTRKs | 0.569596 | 0.244 |
| R-HSA-8854518 | AURKA Activation by TPX2 | 0.573487 | 0.241 |
| R-HSA-5693606 | DNA Double Strand Break Response | 0.578381 | 0.238 |
| R-HSA-196807 | Nicotinate metabolism | 0.578381 | 0.238 |
| R-HSA-446652 | Interleukin-1 family signaling | 0.582539 | 0.235 |
| R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet fun... | 0.583220 | 0.234 |
| R-HSA-9662360 | Sensory processing of sound by inner hair cells of the cochlea | 0.583220 | 0.234 |
| R-HSA-9917777 | Epigenetic regulation by WDR5-containing histone modifying complexes | 0.588903 | 0.230 |
| R-HSA-69202 | Cyclin E associated events during G1/S transition | 0.592732 | 0.227 |
| R-HSA-9764560 | Regulation of CDH1 Gene Transcription | 0.592732 | 0.227 |
| R-HSA-9612973 | Autophagy | 0.595195 | 0.225 |
| R-HSA-427413 | NoRC negatively regulates rRNA expression | 0.597407 | 0.224 |
| R-HSA-5620920 | Cargo trafficking to the periciliary membrane | 0.597407 | 0.224 |
| R-HSA-9006925 | Intracellular signaling by second messengers | 0.599403 | 0.222 |
| R-HSA-9711097 | Cellular response to starvation | 0.601415 | 0.221 |
| R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | 0.602028 | 0.220 |
| R-HSA-199992 | trans-Golgi Network Vesicle Budding | 0.602028 | 0.220 |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | 0.602028 | 0.220 |
| R-HSA-74259 | Purine catabolism | 0.602028 | 0.220 |
| R-HSA-421270 | Cell-cell junction organization | 0.603766 | 0.219 |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | 0.606597 | 0.217 |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | 0.606597 | 0.217 |
| R-HSA-69473 | G2/M DNA damage checkpoint | 0.611113 | 0.214 |
| R-HSA-1222556 | ROS and RNS production in phagocytes | 0.611113 | 0.214 |
| R-HSA-380287 | Centrosome maturation | 0.615578 | 0.211 |
| R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes | 0.615578 | 0.211 |
| R-HSA-1169408 | ISG15 antiviral mechanism | 0.615578 | 0.211 |
| R-HSA-917937 | Iron uptake and transport | 0.615578 | 0.211 |
| R-HSA-388841 | Regulation of T cell activation by CD28 family | 0.616113 | 0.210 |
| R-HSA-9020591 | Interleukin-12 signaling | 0.619992 | 0.208 |
| R-HSA-5689603 | UCH proteinases | 0.619992 | 0.208 |
| R-HSA-9694635 | Translation of Structural Proteins | 0.624356 | 0.205 |
| R-HSA-9659379 | Sensory processing of sound | 0.632934 | 0.199 |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 0.637149 | 0.196 |
| R-HSA-2995410 | Nuclear Envelope (NE) Reassembly | 0.637149 | 0.196 |
| R-HSA-73894 | DNA Repair | 0.637407 | 0.196 |
| R-HSA-5693607 | Processing of DNA double-strand break ends | 0.641317 | 0.193 |
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | 0.641317 | 0.193 |
| R-HSA-6806667 | Metabolism of fat-soluble vitamins | 0.641317 | 0.193 |
| R-HSA-9006931 | Signaling by Nuclear Receptors | 0.643511 | 0.191 |
| R-HSA-72202 | Transport of Mature Transcript to Cytoplasm | 0.645437 | 0.190 |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 0.645437 | 0.190 |
| R-HSA-5689880 | Ub-specific processing proteases | 0.648598 | 0.188 |
| R-HSA-9707564 | Cytoprotection by HMOX1 | 0.649510 | 0.187 |
| R-HSA-2262752 | Cellular responses to stress | 0.652969 | 0.185 |
| R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | 0.653536 | 0.185 |
| R-HSA-9678108 | SARS-CoV-1 Infection | 0.654176 | 0.184 |
| R-HSA-1500620 | Meiosis | 0.657516 | 0.182 |
| R-HSA-6794362 | Protein-protein interactions at synapses | 0.657516 | 0.182 |
| R-HSA-1614635 | Sulfur amino acid metabolism | 0.665341 | 0.177 |
| R-HSA-447115 | Interleukin-12 family signaling | 0.669187 | 0.174 |
| R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA | 0.669534 | 0.174 |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | 0.672988 | 0.172 |
| R-HSA-73884 | Base Excision Repair | 0.680461 | 0.167 |
| R-HSA-69275 | G2/M Transition | 0.683605 | 0.165 |
| R-HSA-453274 | Mitotic G2-G2/M phases | 0.688731 | 0.162 |
| R-HSA-5673001 | RAF/MAP kinase cascade | 0.691011 | 0.161 |
| R-HSA-983712 | Ion channel transport | 0.691269 | 0.160 |
| R-HSA-2682334 | EPH-Ephrin signaling | 0.691353 | 0.160 |
| R-HSA-74752 | Signaling by Insulin receptor | 0.691353 | 0.160 |
| R-HSA-9772573 | Late SARS-CoV-2 Infection Events | 0.691353 | 0.160 |
| R-HSA-9837999 | Mitochondrial protein degradation | 0.698409 | 0.156 |
| R-HSA-1474290 | Collagen formation | 0.698409 | 0.156 |
| R-HSA-72163 | mRNA Splicing - Major Pathway | 0.703704 | 0.153 |
| R-HSA-5684996 | MAPK1/MAPK3 signaling | 0.705416 | 0.152 |
| R-HSA-157579 | Telomere Maintenance | 0.712042 | 0.147 |
| R-HSA-8957275 | Post-translational protein phosphorylation | 0.715354 | 0.145 |
| R-HSA-190236 | Signaling by FGFR | 0.715354 | 0.145 |
| R-HSA-70171 | Glycolysis | 0.721864 | 0.142 |
| R-HSA-948021 | Transport to the Golgi and subsequent modification | 0.722735 | 0.141 |
| R-HSA-1483206 | Glycerophospholipid biosynthesis | 0.725041 | 0.140 |
| R-HSA-9009391 | Extra-nuclear estrogen signaling | 0.725063 | 0.140 |
| R-HSA-2559580 | Oxidative Stress Induced Senescence | 0.728225 | 0.138 |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 0.728225 | 0.138 |
| R-HSA-72172 | mRNA Splicing | 0.729603 | 0.137 |
| R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 0.734442 | 0.134 |
| R-HSA-5619507 | Activation of HOX genes during differentiation | 0.737497 | 0.132 |
| R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogen... | 0.737497 | 0.132 |
| R-HSA-5696398 | Nucleotide Excision Repair | 0.740518 | 0.130 |
| R-HSA-9692914 | SARS-CoV-1-host interactions | 0.743503 | 0.129 |
| R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | 0.746455 | 0.127 |
| R-HSA-9700206 | Signaling by ALK in cancer | 0.746455 | 0.127 |
| R-HSA-211000 | Gene Silencing by RNA | 0.746455 | 0.127 |
| R-HSA-1483249 | Inositol phosphate metabolism | 0.760713 | 0.119 |
| R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | 0.766191 | 0.116 |
| R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l... | 0.768882 | 0.114 |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | 0.771543 | 0.113 |
| R-HSA-4420097 | VEGFA-VEGFR2 Pathway | 0.774174 | 0.111 |
| R-HSA-162906 | HIV Infection | 0.777614 | 0.109 |
| R-HSA-70326 | Glucose metabolism | 0.779345 | 0.108 |
| R-HSA-1592230 | Mitochondrial biogenesis | 0.779345 | 0.108 |
| R-HSA-9705683 | SARS-CoV-2-host interactions | 0.779523 | 0.108 |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | 0.781886 | 0.107 |
| R-HSA-5693538 | Homology Directed Repair | 0.781886 | 0.107 |
| R-HSA-199991 | Membrane Trafficking | 0.784098 | 0.106 |
| R-HSA-8878166 | Transcriptional regulation by RUNX2 | 0.784398 | 0.105 |
| R-HSA-9635486 | Infection with Mycobacterium tuberculosis | 0.789336 | 0.103 |
| R-HSA-8953897 | Cellular responses to stimuli | 0.790675 | 0.102 |
| R-HSA-5683057 | MAPK family signaling cascades | 0.795249 | 0.099 |
| R-HSA-9694516 | SARS-CoV-2 Infection | 0.798256 | 0.098 |
| R-HSA-9851695 | Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes | 0.801195 | 0.096 |
| R-HSA-9841922 | MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesi... | 0.801195 | 0.096 |
| R-HSA-9818564 | Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | 0.801195 | 0.096 |
| R-HSA-69206 | G1/S Transition | 0.801195 | 0.096 |
| R-HSA-194138 | Signaling by VEGF | 0.801195 | 0.096 |
| R-HSA-114608 | Platelet degranulation | 0.805750 | 0.094 |
| R-HSA-69481 | G2/M Checkpoints | 0.805750 | 0.094 |
| R-HSA-8956319 | Nucleotide catabolism | 0.810201 | 0.091 |
| R-HSA-1474165 | Reproduction | 0.814551 | 0.089 |
| R-HSA-5576891 | Cardiac conduction | 0.816689 | 0.088 |
| R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ | 0.820891 | 0.086 |
| R-HSA-9675108 | Nervous system development | 0.825530 | 0.083 |
| R-HSA-74160 | Gene expression (Transcription) | 0.834994 | 0.078 |
| R-HSA-162599 | Late Phase of HIV Life Cycle | 0.842347 | 0.075 |
| R-HSA-8856828 | Clathrin-mediated endocytosis | 0.844166 | 0.074 |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 0.849498 | 0.071 |
| R-HSA-69242 | S Phase | 0.852952 | 0.069 |
| R-HSA-9679191 | Potential therapeutics for SARS | 0.856327 | 0.067 |
| R-HSA-5693532 | DNA Double-Strand Break Repair | 0.861245 | 0.065 |
| R-HSA-73887 | Death Receptor Signaling | 0.862847 | 0.064 |
| R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes | 0.862847 | 0.064 |
| R-HSA-168273 | Influenza Viral RNA Transcription and Replication | 0.864431 | 0.063 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 0.866706 | 0.062 |
| R-HSA-9610379 | HCMV Late Events | 0.867543 | 0.062 |
| R-HSA-162587 | HIV Life Cycle | 0.867543 | 0.062 |
| R-HSA-5633007 | Regulation of TP53 Activity | 0.872080 | 0.059 |
| R-HSA-212436 | Generic Transcription Pathway | 0.873804 | 0.059 |
| R-HSA-5619102 | SLC transporter disorders | 0.882072 | 0.054 |
| R-HSA-72306 | tRNA processing | 0.887430 | 0.052 |
| R-HSA-168255 | Influenza Infection | 0.898615 | 0.046 |
| R-HSA-9679506 | SARS-CoV Infections | 0.900183 | 0.046 |
| R-HSA-201681 | TCF dependent signaling in response to WNT | 0.903225 | 0.044 |
| R-HSA-6798695 | Neutrophil degranulation | 0.914330 | 0.039 |
| R-HSA-9609690 | HCMV Early Events | 0.916814 | 0.038 |
| R-HSA-5653656 | Vesicle-mediated transport | 0.918223 | 0.037 |
| R-HSA-3700989 | Transcriptional Regulation by TP53 | 0.919825 | 0.036 |
| R-HSA-1280218 | Adaptive Immune System | 0.928066 | 0.032 |
| R-HSA-397014 | Muscle contraction | 0.931760 | 0.031 |
| R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 0.935615 | 0.029 |
| R-HSA-73857 | RNA Polymerase II Transcription | 0.936250 | 0.029 |
| R-HSA-196854 | Metabolism of vitamins and cofactors | 0.936505 | 0.028 |
| R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors | 0.944682 | 0.025 |
| R-HSA-913531 | Interferon Signaling | 0.947635 | 0.023 |
| R-HSA-15869 | Metabolism of nucleotides | 0.948424 | 0.023 |
| R-HSA-5619115 | Disorders of transmembrane transporters | 0.954641 | 0.020 |
| R-HSA-9609646 | HCMV Infection | 0.956204 | 0.019 |
| R-HSA-109582 | Hemostasis | 0.956694 | 0.019 |
| R-HSA-8978868 | Fatty acid metabolism | 0.958553 | 0.018 |
| R-HSA-422475 | Axon guidance | 0.959543 | 0.018 |
| R-HSA-446203 | Asparagine N-linked glycosylation | 0.964236 | 0.016 |
| R-HSA-9711123 | Cellular response to chemical stress | 0.964515 | 0.016 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | 0.966921 | 0.015 |
| R-HSA-162582 | Signal Transduction | 0.967002 | 0.015 |
| R-HSA-8953854 | Metabolism of RNA | 0.970656 | 0.013 |
| R-HSA-1280215 | Cytokine Signaling in Immune system | 0.971163 | 0.013 |
| R-HSA-195721 | Signaling by WNT | 0.975026 | 0.011 |
| R-HSA-597592 | Post-translational protein modification | 0.976032 | 0.011 |
| R-HSA-449147 | Signaling by Interleukins | 0.980257 | 0.009 |
| R-HSA-1474244 | Extracellular matrix organization | 0.983043 | 0.007 |
| R-HSA-9824439 | Bacterial Infection Pathways | 0.991630 | 0.004 |
| R-HSA-556833 | Metabolism of lipids | 0.992084 | 0.003 |
| R-HSA-9824446 | Viral Infection Pathways | 0.992252 | 0.003 |
| R-HSA-168256 | Immune System | 0.995003 | 0.002 |
| R-HSA-168249 | Innate Immune System | 0.995814 | 0.002 |
| R-HSA-71387 | Metabolism of carbohydrates and carbohydrate derivatives | 0.996116 | 0.002 |
| R-HSA-112316 | Neuronal System | 0.996671 | 0.001 |
| R-HSA-71291 | Metabolism of amino acids and derivatives | 0.999442 | 0.000 |
| R-HSA-392499 | Metabolism of proteins | 0.999736 | 0.000 |
| R-HSA-382551 | Transport of small molecules | 0.999909 | 0.000 |
| R-HSA-9752946 | Expression and translocation of olfactory receptors | 0.999931 | 0.000 |
| R-HSA-5663205 | Infectious disease | 0.999951 | 0.000 |
| R-HSA-381753 | Olfactory Signaling Pathway | 0.999972 | 0.000 |
| R-HSA-9709957 | Sensory Perception | 0.999995 | 0.000 |
| R-HSA-1643685 | Disease | 1.000000 | 0.000 |
| R-HSA-1430728 | Metabolism | 1.000000 | 0.000 |
Download
| kinase | JSD_mean | pearson_surrounding | kinase_max_IC_position | max_position_JSD |
|---|---|---|---|---|
CDK3 |
0.860 | 0.833 | 1 | 0.823 |
CDK18 |
0.850 | 0.831 | 1 | 0.796 |
CDK17 |
0.850 | 0.851 | 1 | 0.832 |
P38G |
0.847 | 0.864 | 1 | 0.841 |
HIPK2 |
0.845 | 0.760 | 1 | 0.776 |
CDK5 |
0.844 | 0.825 | 1 | 0.711 |
CDK19 |
0.843 | 0.799 | 1 | 0.779 |
CDK7 |
0.843 | 0.814 | 1 | 0.742 |
CDK16 |
0.842 | 0.814 | 1 | 0.817 |
CDK1 |
0.842 | 0.845 | 1 | 0.772 |
CDK13 |
0.838 | 0.821 | 1 | 0.766 |
CDK8 |
0.838 | 0.800 | 1 | 0.739 |
JNK2 |
0.838 | 0.860 | 1 | 0.792 |
P38D |
0.837 | 0.837 | 1 | 0.838 |
KIS |
0.837 | 0.729 | 1 | 0.712 |
CDK12 |
0.836 | 0.820 | 1 | 0.790 |
CDK9 |
0.835 | 0.817 | 1 | 0.758 |
ERK1 |
0.834 | 0.810 | 1 | 0.775 |
CDK14 |
0.831 | 0.811 | 1 | 0.750 |
DYRK2 |
0.830 | 0.744 | 1 | 0.679 |
P38B |
0.830 | 0.810 | 1 | 0.758 |
CDK4 |
0.829 | 0.817 | 1 | 0.799 |
CDK10 |
0.829 | 0.769 | 1 | 0.768 |
CDK6 |
0.828 | 0.805 | 1 | 0.771 |
CDK2 |
0.828 | 0.741 | 1 | 0.637 |
DYRK1B |
0.827 | 0.740 | 1 | 0.737 |
HIPK1 |
0.826 | 0.701 | 1 | 0.657 |
DYRK4 |
0.825 | 0.754 | 1 | 0.785 |
JNK3 |
0.824 | 0.841 | 1 | 0.761 |
ERK2 |
0.823 | 0.822 | 1 | 0.719 |
CLK3 |
0.822 | 0.533 | 1 | 0.416 |
P38A |
0.821 | 0.783 | 1 | 0.679 |
HIPK3 |
0.819 | 0.688 | 1 | 0.628 |
HIPK4 |
0.818 | 0.475 | 1 | 0.449 |
DYRK1A |
0.816 | 0.616 | 1 | 0.636 |
NLK |
0.815 | 0.747 | 1 | 0.452 |
CLK1 |
0.813 | 0.471 | -3 | 0.730 |
DYRK3 |
0.809 | 0.574 | 1 | 0.619 |
SRPK1 |
0.806 | 0.342 | -3 | 0.735 |
CLK4 |
0.804 | 0.434 | -3 | 0.742 |
JNK1 |
0.802 | 0.749 | 1 | 0.794 |
ERK5 |
0.801 | 0.399 | 1 | 0.367 |
SRPK2 |
0.799 | 0.279 | -3 | 0.658 |
CLK2 |
0.799 | 0.426 | -3 | 0.733 |
ICK |
0.792 | 0.364 | -3 | 0.823 |
MAK |
0.791 | 0.480 | -2 | 0.728 |
MTOR |
0.789 | 0.207 | 1 | 0.242 |
CDKL5 |
0.789 | 0.165 | -3 | 0.783 |
MOK |
0.788 | 0.460 | 1 | 0.541 |
CDKL1 |
0.782 | 0.143 | -3 | 0.785 |
PRP4 |
0.781 | 0.445 | -3 | 0.734 |
PRKD1 |
0.780 | 0.012 | -3 | 0.837 |
PRKD2 |
0.780 | 0.037 | -3 | 0.777 |
COT |
0.779 | -0.092 | 2 | 0.876 |
SRPK3 |
0.778 | 0.224 | -3 | 0.698 |
NUAK2 |
0.777 | 0.041 | -3 | 0.821 |
TBK1 |
0.776 | -0.149 | 1 | 0.037 |
PKCD |
0.776 | 0.039 | 2 | 0.826 |
AMPKA1 |
0.776 | -0.003 | -3 | 0.844 |
WNK1 |
0.775 | -0.020 | -2 | 0.877 |
MNK2 |
0.775 | 0.051 | -2 | 0.849 |
ULK2 |
0.775 | -0.133 | 2 | 0.845 |
TSSK1 |
0.775 | 0.008 | -3 | 0.868 |
AMPKA2 |
0.774 | 0.007 | -3 | 0.815 |
PIM3 |
0.774 | -0.024 | -3 | 0.822 |
PKN3 |
0.774 | -0.016 | -3 | 0.810 |
ERK7 |
0.774 | 0.274 | 2 | 0.566 |
CDC7 |
0.774 | -0.118 | 1 | 0.068 |
CAMK1B |
0.773 | 0.002 | -3 | 0.841 |
MST4 |
0.773 | 0.004 | 2 | 0.847 |
NDR1 |
0.772 | -0.019 | -3 | 0.823 |
PRPK |
0.772 | -0.105 | -1 | 0.857 |
PRKD3 |
0.772 | 0.030 | -3 | 0.738 |
CHAK2 |
0.771 | 0.003 | -1 | 0.883 |
TSSK2 |
0.771 | -0.015 | -5 | 0.820 |
RSK2 |
0.771 | 0.013 | -3 | 0.764 |
RSK3 |
0.771 | 0.004 | -3 | 0.759 |
NIK |
0.770 | 0.002 | -3 | 0.861 |
NDR2 |
0.770 | -0.030 | -3 | 0.835 |
AURC |
0.770 | 0.064 | -2 | 0.733 |
PKN2 |
0.770 | -0.019 | -3 | 0.820 |
P90RSK |
0.769 | 0.008 | -3 | 0.762 |
MNK1 |
0.769 | 0.058 | -2 | 0.858 |
NIM1 |
0.769 | -0.046 | 3 | 0.733 |
MELK |
0.769 | -0.022 | -3 | 0.802 |
GCN2 |
0.769 | -0.184 | 2 | 0.824 |
NUAK1 |
0.769 | -0.001 | -3 | 0.777 |
IKKE |
0.769 | -0.173 | 1 | 0.037 |
IRE1 |
0.769 | -0.051 | 1 | 0.048 |
IRE2 |
0.768 | -0.030 | 2 | 0.827 |
PAK6 |
0.768 | 0.052 | -2 | 0.805 |
CAMLCK |
0.768 | 0.032 | -2 | 0.889 |
MARK4 |
0.768 | -0.049 | 4 | 0.855 |
MAPKAPK3 |
0.768 | -0.032 | -3 | 0.779 |
NEK6 |
0.768 | -0.075 | -2 | 0.823 |
ATR |
0.767 | -0.061 | 1 | 0.104 |
PIM1 |
0.767 | 0.034 | -3 | 0.765 |
PHKG1 |
0.767 | -0.030 | -3 | 0.814 |
RAF1 |
0.767 | -0.193 | 1 | 0.049 |
MOS |
0.766 | -0.086 | 1 | 0.107 |
ULK1 |
0.766 | -0.126 | -3 | 0.790 |
PKCZ |
0.766 | 0.018 | 2 | 0.836 |
TGFBR2 |
0.765 | -0.082 | -2 | 0.778 |
HUNK |
0.765 | -0.118 | 2 | 0.851 |
WNK3 |
0.765 | -0.136 | 1 | 0.049 |
PKCB |
0.765 | 0.013 | 2 | 0.790 |
P70S6KB |
0.764 | 0.009 | -3 | 0.781 |
PKACG |
0.764 | 0.005 | -2 | 0.783 |
BMPR2 |
0.764 | -0.184 | -2 | 0.871 |
PAK3 |
0.764 | -0.015 | -2 | 0.847 |
PDHK4 |
0.763 | -0.197 | 1 | 0.115 |
SKMLCK |
0.763 | -0.041 | -2 | 0.870 |
DAPK2 |
0.762 | -0.012 | -3 | 0.848 |
PDHK1 |
0.762 | -0.184 | 1 | 0.094 |
PKG2 |
0.761 | 0.038 | -2 | 0.736 |
NEK7 |
0.761 | -0.161 | -3 | 0.814 |
PKCA |
0.761 | 0.009 | 2 | 0.781 |
LATS2 |
0.761 | -0.043 | -5 | 0.741 |
IKKB |
0.760 | -0.203 | -2 | 0.763 |
QSK |
0.760 | -0.027 | 4 | 0.847 |
SSTK |
0.760 | 0.008 | 4 | 0.855 |
PKCG |
0.760 | -0.005 | 2 | 0.785 |
MLK2 |
0.760 | -0.106 | 2 | 0.863 |
CHAK1 |
0.759 | -0.055 | 2 | 0.853 |
QIK |
0.759 | -0.065 | -3 | 0.816 |
DSTYK |
0.759 | -0.174 | 2 | 0.881 |
PAK1 |
0.759 | -0.010 | -2 | 0.840 |
MAPKAPK2 |
0.758 | -0.033 | -3 | 0.734 |
AURB |
0.758 | 0.039 | -2 | 0.733 |
SIK |
0.758 | -0.030 | -3 | 0.748 |
RIPK3 |
0.758 | -0.150 | 3 | 0.665 |
CAMK4 |
0.758 | -0.070 | -3 | 0.804 |
PHKG2 |
0.758 | -0.024 | -3 | 0.784 |
PKCH |
0.757 | -0.011 | 2 | 0.791 |
SGK3 |
0.757 | 0.015 | -3 | 0.751 |
AKT2 |
0.757 | 0.052 | -3 | 0.673 |
PKCT |
0.757 | 0.003 | 2 | 0.797 |
BRSK2 |
0.757 | -0.061 | -3 | 0.804 |
NEK9 |
0.756 | -0.160 | 2 | 0.875 |
NEK2 |
0.756 | -0.089 | 2 | 0.864 |
PINK1 |
0.756 | 0.178 | 1 | 0.269 |
MLK1 |
0.755 | -0.154 | 2 | 0.850 |
PIM2 |
0.754 | 0.032 | -3 | 0.733 |
MLK3 |
0.754 | -0.055 | 2 | 0.786 |
PKCI |
0.754 | 0.035 | 2 | 0.801 |
LATS1 |
0.754 | 0.010 | -3 | 0.844 |
PKACB |
0.754 | 0.040 | -2 | 0.739 |
IRAK4 |
0.753 | -0.059 | 1 | 0.029 |
MSK2 |
0.753 | -0.021 | -3 | 0.727 |
MPSK1 |
0.753 | 0.039 | 1 | 0.123 |
DCAMKL1 |
0.752 | -0.015 | -3 | 0.779 |
RSK4 |
0.752 | 0.008 | -3 | 0.734 |
PAK2 |
0.752 | -0.028 | -2 | 0.834 |
AKT1 |
0.752 | 0.041 | -3 | 0.695 |
PKR |
0.752 | -0.060 | 1 | 0.066 |
CAMK2D |
0.752 | -0.119 | -3 | 0.833 |
MASTL |
0.751 | -0.187 | -2 | 0.811 |
RIPK1 |
0.751 | -0.187 | 1 | 0.038 |
VRK2 |
0.751 | 0.043 | 1 | 0.151 |
IKKA |
0.751 | -0.134 | -2 | 0.735 |
CAMK2G |
0.751 | -0.150 | 2 | 0.771 |
BCKDK |
0.751 | -0.180 | -1 | 0.781 |
MARK3 |
0.751 | -0.040 | 4 | 0.801 |
CHK1 |
0.750 | -0.045 | -3 | 0.839 |
BRSK1 |
0.750 | -0.058 | -3 | 0.780 |
DNAPK |
0.750 | -0.058 | 1 | 0.107 |
MARK2 |
0.749 | -0.052 | 4 | 0.784 |
PAK5 |
0.748 | 0.018 | -2 | 0.738 |
PKN1 |
0.748 | 0.002 | -3 | 0.712 |
GRK5 |
0.748 | -0.198 | -3 | 0.818 |
CAMK1G |
0.748 | -0.029 | -3 | 0.742 |
PLK4 |
0.748 | -0.108 | 2 | 0.707 |
ANKRD3 |
0.747 | -0.189 | 1 | 0.063 |
SNRK |
0.747 | -0.118 | 2 | 0.757 |
WNK4 |
0.747 | -0.083 | -2 | 0.863 |
DLK |
0.746 | -0.216 | 1 | 0.062 |
MYLK4 |
0.746 | -0.007 | -2 | 0.827 |
ALK4 |
0.746 | -0.081 | -2 | 0.816 |
PKCE |
0.746 | 0.048 | 2 | 0.779 |
BUB1 |
0.746 | 0.060 | -5 | 0.752 |
PRKX |
0.745 | 0.049 | -3 | 0.667 |
YSK4 |
0.745 | -0.159 | 1 | 0.039 |
MSK1 |
0.744 | -0.009 | -3 | 0.737 |
DCAMKL2 |
0.744 | -0.032 | -3 | 0.800 |
MARK1 |
0.744 | -0.072 | 4 | 0.829 |
PAK4 |
0.744 | 0.024 | -2 | 0.742 |
P70S6K |
0.744 | -0.016 | -3 | 0.695 |
BMPR1B |
0.743 | -0.085 | 1 | 0.042 |
ATM |
0.743 | -0.109 | 1 | 0.077 |
TGFBR1 |
0.742 | -0.085 | -2 | 0.782 |
SMG1 |
0.742 | -0.101 | 1 | 0.094 |
PKACA |
0.741 | 0.031 | -2 | 0.696 |
MEK1 |
0.741 | -0.150 | 2 | 0.860 |
TTBK2 |
0.741 | -0.216 | 2 | 0.753 |
AKT3 |
0.741 | 0.044 | -3 | 0.616 |
MST3 |
0.740 | -0.037 | 2 | 0.862 |
HRI |
0.740 | -0.135 | -2 | 0.833 |
NEK5 |
0.739 | -0.122 | 1 | 0.044 |
PLK1 |
0.739 | -0.168 | -2 | 0.795 |
MAPKAPK5 |
0.739 | -0.093 | -3 | 0.704 |
PERK |
0.739 | -0.144 | -2 | 0.819 |
AURA |
0.739 | 0.008 | -2 | 0.710 |
ZAK |
0.738 | -0.143 | 1 | 0.047 |
MLK4 |
0.738 | -0.130 | 2 | 0.772 |
GRK6 |
0.738 | -0.193 | 1 | 0.048 |
GRK1 |
0.738 | -0.119 | -2 | 0.761 |
MEKK6 |
0.738 | -0.052 | 1 | 0.060 |
TAO3 |
0.738 | -0.036 | 1 | 0.084 |
SBK |
0.737 | 0.114 | -3 | 0.564 |
CAMK1D |
0.737 | -0.017 | -3 | 0.674 |
SMMLCK |
0.737 | -0.007 | -3 | 0.799 |
GRK7 |
0.737 | -0.065 | 1 | 0.086 |
MEKK1 |
0.737 | -0.155 | 1 | 0.060 |
LKB1 |
0.737 | -0.029 | -3 | 0.815 |
MEK5 |
0.736 | -0.150 | 2 | 0.866 |
PBK |
0.736 | -0.004 | 1 | 0.095 |
TAO2 |
0.736 | -0.024 | 2 | 0.881 |
LOK |
0.735 | -0.020 | -2 | 0.807 |
CAMK2A |
0.735 | -0.073 | 2 | 0.731 |
CAMK1A |
0.735 | 0.005 | -3 | 0.646 |
HGK |
0.734 | -0.028 | 3 | 0.864 |
MRCKB |
0.734 | 0.031 | -3 | 0.723 |
CAMK2B |
0.734 | -0.109 | 2 | 0.712 |
DRAK1 |
0.734 | -0.154 | 1 | 0.032 |
TNIK |
0.734 | 0.006 | 3 | 0.889 |
ACVR2A |
0.734 | -0.128 | -2 | 0.773 |
NEK4 |
0.733 | -0.108 | 1 | 0.035 |
SGK1 |
0.733 | 0.042 | -3 | 0.597 |
MEKK2 |
0.733 | -0.140 | 2 | 0.852 |
MAP3K15 |
0.733 | -0.077 | 1 | 0.062 |
CHK2 |
0.733 | -0.005 | -3 | 0.623 |
MRCKA |
0.732 | 0.028 | -3 | 0.736 |
TLK2 |
0.732 | -0.178 | 1 | 0.042 |
ROCK2 |
0.732 | 0.027 | -3 | 0.774 |
PDK1 |
0.732 | -0.064 | 1 | 0.091 |
BRAF |
0.731 | -0.156 | -4 | 0.741 |
GSK3A |
0.731 | 0.132 | 4 | 0.315 |
NEK8 |
0.730 | -0.132 | 2 | 0.869 |
PKG1 |
0.730 | 0.010 | -2 | 0.676 |
GRK4 |
0.730 | -0.233 | -2 | 0.779 |
ACVR2B |
0.730 | -0.142 | -2 | 0.779 |
KHS1 |
0.729 | -0.024 | 1 | 0.058 |
NEK11 |
0.729 | -0.128 | 1 | 0.077 |
ALK2 |
0.728 | -0.124 | -2 | 0.786 |
PLK3 |
0.728 | -0.158 | 2 | 0.759 |
NEK1 |
0.728 | -0.098 | 1 | 0.029 |
MINK |
0.728 | -0.075 | 1 | 0.038 |
LRRK2 |
0.728 | 0.008 | 2 | 0.882 |
FAM20C |
0.727 | -0.063 | 2 | 0.568 |
KHS2 |
0.727 | -0.001 | 1 | 0.069 |
GAK |
0.727 | -0.048 | 1 | 0.106 |
GCK |
0.726 | -0.071 | 1 | 0.063 |
NEK3 |
0.726 | -0.080 | 1 | 0.063 |
CAMKK2 |
0.726 | -0.114 | -2 | 0.797 |
CAMKK1 |
0.726 | -0.159 | -2 | 0.798 |
AAK1 |
0.725 | 0.031 | 1 | 0.128 |
IRAK1 |
0.725 | -0.192 | -1 | 0.768 |
HASPIN |
0.725 | 0.017 | -1 | 0.720 |
MEKK3 |
0.725 | -0.208 | 1 | 0.057 |
BMPR1A |
0.725 | -0.096 | 1 | 0.035 |
DAPK3 |
0.725 | -0.020 | -3 | 0.780 |
SLK |
0.725 | -0.031 | -2 | 0.735 |
EEF2K |
0.725 | -0.040 | 3 | 0.839 |
HPK1 |
0.724 | -0.065 | 1 | 0.065 |
DMPK1 |
0.724 | 0.058 | -3 | 0.741 |
GRK2 |
0.724 | -0.126 | -2 | 0.671 |
BIKE |
0.723 | -0.005 | 1 | 0.110 |
TLK1 |
0.723 | -0.182 | -2 | 0.776 |
ROCK1 |
0.722 | 0.023 | -3 | 0.738 |
YSK1 |
0.722 | -0.085 | 2 | 0.849 |
CRIK |
0.721 | 0.027 | -3 | 0.698 |
MST2 |
0.720 | -0.133 | 1 | 0.046 |
MST1 |
0.719 | -0.104 | 1 | 0.037 |
PASK |
0.719 | -0.093 | -3 | 0.834 |
GSK3B |
0.719 | -0.006 | 4 | 0.307 |
TTBK1 |
0.718 | -0.182 | 2 | 0.674 |
LIMK2_TYR |
0.717 | 0.176 | -3 | 0.887 |
VRK1 |
0.717 | -0.158 | 2 | 0.886 |
STK33 |
0.716 | -0.114 | 2 | 0.654 |
CK1E |
0.715 | -0.083 | -3 | 0.480 |
RIPK2 |
0.715 | -0.193 | 1 | 0.034 |
TAO1 |
0.715 | -0.046 | 1 | 0.059 |
DAPK1 |
0.714 | -0.032 | -3 | 0.758 |
MEK2 |
0.713 | -0.173 | 2 | 0.855 |
MYO3B |
0.713 | -0.034 | 2 | 0.868 |
TAK1 |
0.710 | -0.202 | 1 | 0.038 |
CK1G1 |
0.709 | -0.114 | -3 | 0.457 |
PDHK3_TYR |
0.709 | 0.066 | 4 | 0.864 |
MYO3A |
0.708 | -0.042 | 1 | 0.056 |
TESK1_TYR |
0.708 | 0.056 | 3 | 0.833 |
ASK1 |
0.706 | -0.113 | 1 | 0.063 |
CK1D |
0.706 | -0.062 | -3 | 0.426 |
PKMYT1_TYR |
0.706 | 0.104 | 3 | 0.781 |
OSR1 |
0.704 | -0.084 | 2 | 0.830 |
CK2A2 |
0.703 | -0.125 | 1 | 0.038 |
LIMK1_TYR |
0.703 | 0.054 | 2 | 0.894 |
TNNI3K_TYR |
0.702 | 0.012 | 1 | 0.091 |
TTK |
0.701 | -0.100 | -2 | 0.790 |
CK1A2 |
0.700 | -0.086 | -3 | 0.425 |
GRK3 |
0.700 | -0.145 | -2 | 0.618 |
MAP2K7_TYR |
0.698 | -0.101 | 2 | 0.879 |
TNK1 |
0.698 | -0.024 | 3 | 0.739 |
PINK1_TYR |
0.697 | -0.105 | 1 | 0.106 |
PDHK4_TYR |
0.696 | -0.024 | 2 | 0.868 |
RET |
0.696 | -0.134 | 1 | 0.076 |
NEK10_TYR |
0.695 | -0.080 | 1 | 0.068 |
ROS1 |
0.695 | -0.112 | 3 | 0.743 |
MAP2K4_TYR |
0.695 | -0.086 | -1 | 0.856 |
JAK2 |
0.694 | -0.128 | 1 | 0.086 |
TYRO3 |
0.692 | -0.135 | 3 | 0.771 |
TYK2 |
0.692 | -0.197 | 1 | 0.063 |
CK2A1 |
0.692 | -0.137 | 1 | 0.032 |
JAK1 |
0.691 | -0.080 | 1 | 0.061 |
CSF1R |
0.691 | -0.103 | 3 | 0.736 |
PLK2 |
0.691 | -0.121 | -3 | 0.779 |
MST1R |
0.691 | -0.124 | 3 | 0.751 |
MAP2K6_TYR |
0.691 | -0.076 | -1 | 0.858 |
DDR1 |
0.685 | -0.125 | 4 | 0.805 |
STLK3 |
0.685 | -0.186 | 1 | 0.034 |
BMPR2_TYR |
0.685 | -0.085 | -1 | 0.801 |
JAK3 |
0.685 | -0.138 | 1 | 0.071 |
ABL2 |
0.685 | -0.131 | -1 | 0.791 |
TEK |
0.685 | -0.022 | 3 | 0.691 |
PDHK1_TYR |
0.684 | -0.164 | -1 | 0.859 |
FGFR1 |
0.684 | -0.058 | 3 | 0.690 |
ALPHAK3 |
0.683 | -0.133 | -1 | 0.747 |
ABL1 |
0.683 | -0.128 | -1 | 0.791 |
YES1 |
0.682 | -0.116 | -1 | 0.843 |
TNK2 |
0.682 | -0.132 | 3 | 0.688 |
EPHA6 |
0.681 | -0.151 | -1 | 0.778 |
PDGFRB |
0.680 | -0.189 | 3 | 0.751 |
FGFR2 |
0.678 | -0.090 | 3 | 0.700 |
PDGFRA |
0.677 | -0.185 | 3 | 0.758 |
EPHB4 |
0.677 | -0.186 | -1 | 0.768 |
FGR |
0.676 | -0.199 | 1 | 0.038 |
FLT3 |
0.676 | -0.187 | 3 | 0.755 |
AXL |
0.676 | -0.175 | 3 | 0.706 |
TXK |
0.676 | -0.137 | 1 | 0.036 |
KDR |
0.676 | -0.121 | 3 | 0.684 |
DDR2 |
0.674 | -0.048 | 3 | 0.655 |
ITK |
0.674 | -0.167 | -1 | 0.756 |
LCK |
0.673 | -0.141 | -1 | 0.779 |
WEE1_TYR |
0.673 | -0.076 | -1 | 0.728 |
INSRR |
0.673 | -0.180 | 3 | 0.684 |
KIT |
0.672 | -0.167 | 3 | 0.726 |
HCK |
0.671 | -0.192 | -1 | 0.780 |
YANK3 |
0.671 | -0.096 | 2 | 0.396 |
FER |
0.670 | -0.240 | 1 | 0.051 |
BLK |
0.670 | -0.131 | -1 | 0.787 |
MERTK |
0.669 | -0.189 | 3 | 0.701 |
ALK |
0.669 | -0.180 | 3 | 0.654 |
MET |
0.666 | -0.164 | 3 | 0.724 |
EPHB1 |
0.664 | -0.242 | 1 | 0.033 |
BTK |
0.664 | -0.230 | -1 | 0.728 |
SRMS |
0.664 | -0.239 | 1 | 0.027 |
TEC |
0.663 | -0.182 | -1 | 0.706 |
EPHA4 |
0.663 | -0.161 | 2 | 0.746 |
FGFR3 |
0.663 | -0.120 | 3 | 0.672 |
EPHB3 |
0.662 | -0.234 | -1 | 0.745 |
INSR |
0.661 | -0.188 | 3 | 0.674 |
EPHB2 |
0.661 | -0.216 | -1 | 0.740 |
PTK2B |
0.661 | -0.132 | -1 | 0.772 |
LTK |
0.661 | -0.204 | 3 | 0.659 |
EPHA1 |
0.660 | -0.198 | 3 | 0.700 |
BMX |
0.660 | -0.166 | -1 | 0.659 |
MUSK |
0.660 | -0.139 | 1 | 0.020 |
NTRK2 |
0.659 | -0.240 | 3 | 0.673 |
FRK |
0.658 | -0.199 | -1 | 0.774 |
FLT4 |
0.658 | -0.188 | 3 | 0.656 |
CK1A |
0.658 | -0.116 | -3 | 0.329 |
MATK |
0.658 | -0.118 | -1 | 0.731 |
PTK6 |
0.658 | -0.232 | -1 | 0.715 |
NTRK1 |
0.657 | -0.255 | -1 | 0.781 |
ERBB2 |
0.657 | -0.211 | 1 | 0.051 |
FYN |
0.654 | -0.158 | -1 | 0.750 |
NTRK3 |
0.654 | -0.200 | -1 | 0.727 |
LYN |
0.652 | -0.198 | 3 | 0.644 |
EPHA7 |
0.651 | -0.207 | 2 | 0.771 |
FLT1 |
0.651 | -0.210 | -1 | 0.753 |
EGFR |
0.651 | -0.156 | 1 | 0.037 |
SRC |
0.649 | -0.169 | -1 | 0.770 |
EPHA3 |
0.647 | -0.217 | 2 | 0.736 |
CSK |
0.647 | -0.188 | 2 | 0.776 |
FGFR4 |
0.644 | -0.162 | -1 | 0.726 |
IGF1R |
0.640 | -0.185 | 3 | 0.607 |
CK1G3 |
0.639 | -0.115 | -3 | 0.277 |
EPHA8 |
0.639 | -0.201 | -1 | 0.710 |
EPHA5 |
0.638 | -0.229 | 2 | 0.740 |
YANK2 |
0.634 | -0.121 | 2 | 0.408 |
ERBB4 |
0.633 | -0.154 | 1 | 0.036 |
PTK2 |
0.630 | -0.149 | -1 | 0.670 |
EPHA2 |
0.628 | -0.210 | -1 | 0.657 |
SYK |
0.628 | -0.180 | -1 | 0.664 |
FES |
0.623 | -0.190 | -1 | 0.654 |
ZAP70 |
0.623 | -0.122 | -1 | 0.613 |
CK1G2 |
0.606 | -0.136 | -3 | 0.373 |